AURKC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)7.70568649
2piRNA metabolic process (GO:0034587)7.03366270
3regulation of retinoic acid receptor signaling pathway (GO:0048385)6.20757890
4metaphase plate congression (GO:0051310)6.15600012
5regulation of acrosome reaction (GO:0060046)5.91454209
6positive regulation of histone H3-K4 methylation (GO:0051571)5.70256248
7regulation of female gonad development (GO:2000194)5.66215261
8retinal cone cell development (GO:0046549)5.31882343
9establishment of chromosome localization (GO:0051303)5.31664260
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.29217458
11histone H2A monoubiquitination (GO:0035518)5.29120123
12regulation of spindle organization (GO:0090224)5.23965127
13protein K6-linked ubiquitination (GO:0085020)5.12931493
14regulation of histone H3-K9 methylation (GO:0051570)5.10180337
15female gamete generation (GO:0007292)5.08350322
16synapsis (GO:0007129)5.05595167
17maturation of 5.8S rRNA (GO:0000460)4.99537489
18regulation of mitotic spindle organization (GO:0060236)4.98103504
19protein localization to kinetochore (GO:0034501)4.96687886
20multicellular organism reproduction (GO:0032504)4.95140544
21negative regulation of meiosis (GO:0045835)4.93375256
22positive regulation of chromosome segregation (GO:0051984)4.90674632
23male meiosis (GO:0007140)4.90266708
24mitotic chromosome condensation (GO:0007076)4.86354354
25regulation of DNA methylation (GO:0044030)4.81926328
26CENP-A containing nucleosome assembly (GO:0034080)4.77499957
27DNA replication checkpoint (GO:0000076)4.67248055
28DNA methylation involved in gamete generation (GO:0043046)4.66862017
29regulation of meiosis (GO:0040020)4.62421930
30chromatin remodeling at centromere (GO:0031055)4.60666975
31mitotic sister chromatid segregation (GO:0000070)4.49793138
32protein localization to chromosome, centromeric region (GO:0071459)4.49531808
33regulation of exit from mitosis (GO:0007096)4.47667695
34histone H2A ubiquitination (GO:0033522)4.47069605
35oocyte maturation (GO:0001556)4.42123234
36* meiotic cell cycle (GO:0051321)4.41668554
37histone exchange (GO:0043486)4.35687770
38DNA replication-independent nucleosome organization (GO:0034724)4.30339394
39DNA replication-independent nucleosome assembly (GO:0006336)4.30339394
40spindle checkpoint (GO:0031577)4.28372940
41meiotic chromosome segregation (GO:0045132)4.23488030
42mitotic nuclear envelope disassembly (GO:0007077)4.23422327
43negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.21270638
44regulation of sister chromatid cohesion (GO:0007063)4.17182632
45protein localization to chromosome (GO:0034502)4.09402752
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.06465194
47glycine transport (GO:0015816)4.05828926
48negative regulation of histone methylation (GO:0031061)4.05420657
49chromosome segregation (GO:0007059)4.04213494
50regulation of chromosome segregation (GO:0051983)4.02328076
51negative regulation of meiotic cell cycle (GO:0051447)3.99587330
52oocyte development (GO:0048599)3.99498807
53membrane disassembly (GO:0030397)3.97257902
54nuclear envelope disassembly (GO:0051081)3.97257902
55centriole replication (GO:0007099)3.94706598
56mitotic spindle checkpoint (GO:0071174)3.93816424
57ribosome assembly (GO:0042255)3.86321873
58positive regulation of mitotic sister chromatid separation (GO:1901970)3.81783005
59positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.81783005
60positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.81783005
61chromosome organization involved in meiosis (GO:0070192)3.80423397
62* attachment of spindle microtubules to kinetochore (GO:0008608)3.77586608
63negative regulation of chromosome segregation (GO:0051985)3.75818755
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.75652222
65kinetochore assembly (GO:0051382)3.72515676
66positive regulation of histone methylation (GO:0031062)3.69473365
67negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.68540567
68negative regulation of sister chromatid segregation (GO:0033046)3.68540567
69negative regulation of mitotic sister chromatid separation (GO:2000816)3.68540567
70negative regulation of mitotic sister chromatid segregation (GO:0033048)3.68540567
71regulation of mitotic metaphase/anaphase transition (GO:0030071)3.65653617
72negative regulation of reproductive process (GO:2000242)3.64549827
73DNA damage induced protein phosphorylation (GO:0006975)3.64040312
74regulation of meiotic cell cycle (GO:0051445)3.62513017
75sister chromatid segregation (GO:0000819)3.60631944
76mitotic spindle assembly checkpoint (GO:0007094)3.60336022
77ventricular cardiac muscle cell development (GO:0055015)3.56550070
78regulation of histone H3-K27 methylation (GO:0061085)3.54689474
79spindle assembly checkpoint (GO:0071173)3.53312755
80regulation of mitotic sister chromatid separation (GO:0010965)3.52775131
81regulation of mitotic sister chromatid segregation (GO:0033047)3.52775131
82regulation of sister chromatid segregation (GO:0033045)3.52775131
83meiotic cell cycle process (GO:1903046)3.52140750
84regulation of histone H3-K4 methylation (GO:0051569)3.51572482
85negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.51466808
86negative regulation of DNA-templated transcription, elongation (GO:0032785)3.51466808
87synaptonemal complex assembly (GO:0007130)3.50697130
88kinetochore organization (GO:0051383)3.44734028
89binding of sperm to zona pellucida (GO:0007339)3.44305927
90meiosis I (GO:0007127)3.43579946
91regulation of steroid hormone secretion (GO:2000831)3.42777230
92meiotic nuclear division (GO:0007126)3.41600396
93negative regulation of nuclear division (GO:0051784)3.40501808
94regulation of histone methylation (GO:0031060)3.39727353
95chromatin assembly or disassembly (GO:0006333)3.39473523
96nuclear envelope organization (GO:0006998)3.38026377
97gene silencing by RNA (GO:0031047)3.37683107
98DNA alkylation (GO:0006305)3.33359509
99DNA methylation (GO:0006306)3.33359509
100negative regulation of cell division (GO:0051782)3.32741875
101negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.32279413
102proteasome assembly (GO:0043248)3.32190148
103monoubiquitinated protein deubiquitination (GO:0035520)3.31948565
104positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28847057
105folic acid metabolic process (GO:0046655)3.28801166
106DNA replication-dependent nucleosome organization (GO:0034723)3.27773707
107DNA replication-dependent nucleosome assembly (GO:0006335)3.27773707
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27768945
109male meiosis I (GO:0007141)3.27228538
110regulation of meiosis I (GO:0060631)3.26246624
111reproduction (GO:0000003)3.25905246
112regulation of translation in response to stress (GO:0043555)3.25359080
113positive regulation of Cdc42 GTPase activity (GO:0043089)3.24400167
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19189316
115chromatin assembly (GO:0031497)3.19037780
116sister chromatid cohesion (GO:0007062)3.18667232
117nuclear pore organization (GO:0006999)3.17851290
118translesion synthesis (GO:0019985)3.16860287
119negative regulation of mitosis (GO:0045839)3.16820103
120synaptonemal complex organization (GO:0070193)3.16801334
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15129260
122gene silencing (GO:0016458)3.14077642
123DNA replication initiation (GO:0006270)3.13133460
124regulation of cell maturation (GO:1903429)3.12037298
125protein kinase C signaling (GO:0070528)3.10231115
1267-methylguanosine mRNA capping (GO:0006370)3.09482604
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09348290
128intestinal epithelial cell development (GO:0060576)3.09025630
129regulation of spindle checkpoint (GO:0090231)3.07937476
130rRNA modification (GO:0000154)3.07613869
131regulation of centrosome cycle (GO:0046605)3.04848340
132chromosome condensation (GO:0030261)3.04447180
133positive regulation of meiosis (GO:0045836)3.03081194
134regulation of RNA export from nucleus (GO:0046831)2.99296004
135regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.98606623
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.97645301
137positive regulation of gastrulation (GO:2000543)2.97427647
138fertilization (GO:0009566)2.95564910
139mitotic G2/M transition checkpoint (GO:0044818)2.93940598
140base-excision repair, AP site formation (GO:0006285)2.92930672
141N-terminal protein amino acid acetylation (GO:0006474)2.92323771
142primitive streak formation (GO:0090009)2.91191003
143telomere maintenance via semi-conservative replication (GO:0032201)2.90580255
144nuclear pore complex assembly (GO:0051292)2.89532162
145histone H3-K9 demethylation (GO:0033169)2.88633595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34912131
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.26653412
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.36491288
4AR_21909140_ChIP-Seq_LNCAP_Human3.84141767
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.82266020
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.74109604
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50442417
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.43350878
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20706505
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.87715059
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.71595741
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.69452461
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.64729374
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.61559904
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60523839
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34059944
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.30117699
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.29010279
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22048366
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16291824
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14364347
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.12673104
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02963226
24EZH2_22144423_ChIP-Seq_EOC_Human10.0385425
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94612236
26ZNF274_21170338_ChIP-Seq_K562_Hela1.90276140
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.88188082
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.85926339
29GABP_19822575_ChIP-Seq_HepG2_Human1.85756274
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84244051
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82047980
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81108171
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.78709514
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78123896
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74136975
36VDR_23849224_ChIP-Seq_CD4+_Human1.72679655
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70810054
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66595965
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63358135
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62579471
41DCP1A_22483619_ChIP-Seq_HELA_Human1.62064694
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60609536
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55882459
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53963391
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50906826
46KDM5A_27292631_Chip-Seq_BREAST_Human1.48106930
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48058870
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45027275
49NANOG_21062744_ChIP-ChIP_HESCs_Human1.43714658
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43385586
51MYC_18940864_ChIP-ChIP_HL60_Human1.43298621
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43189614
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41049941
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.26290771
55SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25786070
56FOXP3_21729870_ChIP-Seq_TREG_Human1.25234683
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24751474
58XRN2_22483619_ChIP-Seq_HELA_Human1.20098759
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17980182
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17107160
61GBX2_23144817_ChIP-Seq_PC3_Human1.16518093
62E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15056381
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.14713396
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14556117
65IRF1_19129219_ChIP-ChIP_H3396_Human1.13914275
66DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12527933
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12464679
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12324007
69TTF2_22483619_ChIP-Seq_HELA_Human1.11287586
70ELK1_19687146_ChIP-ChIP_HELA_Human1.09989679
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09090601
72LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06015411
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04949411
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04757021
75TP53_22573176_ChIP-Seq_HFKS_Human1.04653481
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04559281
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04266448
78VDR_22108803_ChIP-Seq_LS180_Human1.04086908
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.03970366
80RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03947168
81KAP1_27257070_Chip-Seq_ESCs_Mouse1.02357849
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.00591702
83SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00324280
84TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00076739
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99066108
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98482192
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98454652
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97564819
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97221670
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.97197727
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95623369
92YY1_21170310_ChIP-Seq_MESCs_Mouse0.94534738
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92759064
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92615129
95TCF4_23295773_ChIP-Seq_U87_Human0.92079953
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91971442
97* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.91825854
98* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90748537
99RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88941643
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87712852
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86897404
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86897404
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86897404
104FOXH1_21741376_ChIP-Seq_EPCs_Human0.86849609
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86040863
106CBP_20019798_ChIP-Seq_JUKART_Human0.85593040
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85593040
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85163506
109NANOG_20526341_ChIP-Seq_ESCs_Human0.83214859
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82798799
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81079379
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80629602
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80292075
114P300_19829295_ChIP-Seq_ESCs_Human0.79951822
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.79359370
116GATA3_21867929_ChIP-Seq_TH1_Mouse0.79083046
117STAT1_17558387_ChIP-Seq_HELA_Human0.79055607
118EWS_26573619_Chip-Seq_HEK293_Human0.79050291
119* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.78442376
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77657004
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77382771
122AR_25329375_ChIP-Seq_VCAP_Human0.76558637
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76039437
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76039437
125FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75262866
126HTT_18923047_ChIP-ChIP_STHdh_Human0.75041736
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.74600447
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74280355
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73472804
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.72898865
131TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.72310211
132PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72251792
133SMAD4_21799915_ChIP-Seq_A2780_Human0.72235286
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.71729153
135NANOG_19829295_ChIP-Seq_ESCs_Human0.71109466
136SOX2_19829295_ChIP-Seq_ESCs_Human0.71109466
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70493902
138ZNF263_19887448_ChIP-Seq_K562_Human0.70149496
139CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69777374
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69770337
141RUNX2_22187159_ChIP-Seq_PCA_Human0.69675207
142PADI4_21655091_ChIP-ChIP_MCF-7_Human0.69195965
143RNF2_27304074_Chip-Seq_NSC_Mouse0.67467988
144STAT3_23295773_ChIP-Seq_U87_Human0.67166558
145BCAT_22108803_ChIP-Seq_LS180_Human0.66506331
146SALL4_22934838_ChIP-ChIP_CD34+_Human0.64922751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.23694078
2MP0003693_abnormal_embryo_hatching5.92730051
3MP0003111_abnormal_nucleus_morphology4.53913598
4MP0005451_abnormal_body_composition4.43229392
5MP0010094_abnormal_chromosome_stability4.34751569
6MP0004957_abnormal_blastocyst_morpholog3.92473651
7MP0008877_abnormal_DNA_methylation3.80672905
8MP0003077_abnormal_cell_cycle3.77659402
9MP0003646_muscle_fatigue3.37815098
10MP0008789_abnormal_olfactory_epithelium3.29513383
11MP0002653_abnormal_ependyma_morphology3.10792439
12MP0005394_taste/olfaction_phenotype2.87280514
13MP0005499_abnormal_olfactory_system2.87280514
14MP0005395_other_phenotype2.69404244
15MP0008932_abnormal_embryonic_tissue2.52203043
16MP0008057_abnormal_DNA_replication2.48513776
17MP0001986_abnormal_taste_sensitivity2.47930251
18MP0008260_abnormal_autophagy2.46124734
19* MP0001929_abnormal_gametogenesis2.44337788
20MP0002210_abnormal_sex_determination2.36649686
21MP0001119_abnormal_female_reproductive2.32768418
22MP0003699_abnormal_female_reproductive2.29969275
23MP0000653_abnormal_sex_gland2.24478330
24MP0003123_paternal_imprinting2.23256316
25MP0008058_abnormal_DNA_repair2.19565688
26MP0002102_abnormal_ear_morphology2.08685603
27MP0010030_abnormal_orbit_morphology2.00502658
28MP0003315_abnormal_perineum_morphology1.95641699
29MP0002139_abnormal_hepatobiliary_system1.91542241
30MP0008007_abnormal_cellular_replicative1.90911227
31MP0001730_embryonic_growth_arrest1.87221865
32MP0000350_abnormal_cell_proliferation1.83707086
33MP0001145_abnormal_male_reproductive1.82454546
34MP0002138_abnormal_hepatobiliary_system1.80396531
35MP0002234_abnormal_pharynx_morphology1.69360030
36MP0003879_abnormal_hair_cell1.65862385
37MP0008995_early_reproductive_senescence1.60466892
38MP0005360_urolithiasis1.59120679
39MP0003937_abnormal_limbs/digits/tail_de1.57555731
40MP0003786_premature_aging1.53916785
41* MP0002161_abnormal_fertility/fecundity1.52232728
42MP0002085_abnormal_embryonic_tissue1.50046136
43MP0006292_abnormal_olfactory_placode1.47791148
44MP0000579_abnormal_nail_morphology1.45244561
45MP0001672_abnormal_embryogenesis/_devel1.44828696
46MP0005380_embryogenesis_phenotype1.44828696
47MP0005423_abnormal_somatic_nervous1.43113372
48MP0001697_abnormal_embryo_size1.39868979
49MP0005408_hypopigmentation1.36651052
50MP0003195_calcinosis1.30415833
51MP0001293_anophthalmia1.29359904
52MP0003698_abnormal_male_reproductive1.27027746
53MP0003136_yellow_coat_color1.26161821
54MP0002084_abnormal_developmental_patter1.21960822
55MP0004264_abnormal_extraembryonic_tissu1.19284979
56MP0003121_genomic_imprinting1.17124915
57MP0000631_abnormal_neuroendocrine_gland1.16286859
58MP0009840_abnormal_foam_cell1.13791425
59MP0002019_abnormal_tumor_incidence1.11669194
60MP0010234_abnormal_vibrissa_follicle1.11350943
61MP0002080_prenatal_lethality1.07970587
62MP0003984_embryonic_growth_retardation1.06795046
63MP0006276_abnormal_autonomic_nervous1.04289335
64MP0002088_abnormal_embryonic_growth/wei1.03510353
65MP0005389_reproductive_system_phenotype0.99290887
66MP0000490_abnormal_crypts_of0.97415007
67MP0002233_abnormal_nose_morphology0.96077346
68MP0010307_abnormal_tumor_latency0.96009340
69MP0000372_irregular_coat_pigmentation0.94742681
70MP0005621_abnormal_cell_physiology0.94288462
71MP0001529_abnormal_vocalization0.90910224
72MP0004142_abnormal_muscle_tone0.90132018
73MP0005187_abnormal_penis_morphology0.90090692
74MP0001905_abnormal_dopamine_level0.89494947
75MP0000678_abnormal_parathyroid_gland0.89490700
76MP0003787_abnormal_imprinting0.88413820
77MP0002090_abnormal_vision0.86252101
78MP0002086_abnormal_extraembryonic_tissu0.85735496
79MP0002272_abnormal_nervous_system0.83179890
80MP0005551_abnormal_eye_electrophysiolog0.83086904
81MP0001919_abnormal_reproductive_system0.82514636
82MP0000313_abnormal_cell_death0.81979863
83MP0005310_abnormal_salivary_gland0.81138009
84MP0006036_abnormal_mitochondrial_physio0.81069502
85MP0000049_abnormal_middle_ear0.80975529
86MP0003950_abnormal_plasma_membrane0.78258634
87MP0001984_abnormal_olfaction0.77798350
88MP0000566_synostosis0.77525836
89MP0009379_abnormal_foot_pigmentation0.77174767
90MP0005384_cellular_phenotype0.76026480
91MP0002160_abnormal_reproductive_system0.75072102
92MP0003453_abnormal_keratinocyte_physiol0.74416394
93MP0002249_abnormal_larynx_morphology0.74338405
94MP0001915_intracranial_hemorrhage0.74214816
95MP0006072_abnormal_retinal_apoptosis0.73669679
96MP0003890_abnormal_embryonic-extraembry0.70886511
97MP0000639_abnormal_adrenal_gland0.67107129
98MP0003755_abnormal_palate_morphology0.66478931
99MP0001502_abnormal_circadian_rhythm0.65490720
100MP0004145_abnormal_muscle_electrophysio0.64308128
101MP0001963_abnormal_hearing_physiology0.64180579
102MP0010678_abnormal_skin_adnexa0.63864702
103MP0002396_abnormal_hematopoietic_system0.63370044
104MP0005410_abnormal_fertilization0.61773656
105MP0002638_abnormal_pupillary_reflex0.61574821
106MP0004215_abnormal_myocardial_fiber0.61387217
107MP0000762_abnormal_tongue_morphology0.59617922
108MP0002269_muscular_atrophy0.59367469
109MP0002163_abnormal_gland_morphology0.58707221
110MP0000427_abnormal_hair_cycle0.58620691
111MP0001849_ear_inflammation0.58590983
112MP0003252_abnormal_bile_duct0.56780519
113MP0003186_abnormal_redox_activity0.55737476
114MP0009333_abnormal_splenocyte_physiolog0.54980413
115MP0000613_abnormal_salivary_gland0.54763963
116MP0004019_abnormal_vitamin_homeostasis0.54756553
117MP0005646_abnormal_pituitary_gland0.54574012
118MP0003119_abnormal_digestive_system0.53528569
119MP0000647_abnormal_sebaceous_gland0.53404562
120MP0002735_abnormal_chemical_nociception0.53039089
121MP0003936_abnormal_reproductive_system0.53002418
122MP0004185_abnormal_adipocyte_glucose0.52344279
123MP0004782_abnormal_surfactant_physiolog0.52294527
124MP0000627_abnormal_mammary_gland0.52095894
125MP0006035_abnormal_mitochondrial_morpho0.50837716
126MP0003938_abnormal_ear_development0.50149123
127MP0001485_abnormal_pinna_reflex0.50038551
128MP0001501_abnormal_sleep_pattern0.49183638
129MP0005647_abnormal_sex_gland0.47490158
130MP0010386_abnormal_urinary_bladder0.46706111
131MP0003806_abnormal_nucleotide_metabolis0.46140154
132MP0005397_hematopoietic_system_phenotyp0.46041319
133MP0001545_abnormal_hematopoietic_system0.46041319
134MP0003183_abnormal_peptide_metabolism0.45751530
135MP0002295_abnormal_pulmonary_circulatio0.45729923
136MP0002127_abnormal_cardiovascular_syste0.44758399
137MP0001324_abnormal_eye_pigmentation0.44352998
138MP0004043_abnormal_pH_regulation0.44251713
139MP0000432_abnormal_head_morphology0.44201238
140MP0009745_abnormal_behavioral_response0.43631352
141MP0003221_abnormal_cardiomyocyte_apopto0.43329542
142MP0010368_abnormal_lymphatic_system0.43018001
143MP0000358_abnormal_cell_content/0.42316398
144MP0003861_abnormal_nervous_system0.41869359
145MP0000462_abnormal_digestive_system0.39871847
146MP0002932_abnormal_joint_morphology0.38693011
147MP0003941_abnormal_skin_development0.38363701

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)7.12391947
2Breast hypoplasia (HP:0003187)6.66776350
3Abnormality of the labia minora (HP:0012880)5.08966787
4Premature ovarian failure (HP:0008209)5.01045478
5Patellar aplasia (HP:0006443)4.89138423
6Hypophosphatemic rickets (HP:0004912)4.61654905
7Aplasia/Hypoplasia of the patella (HP:0006498)4.59674078
8Abnormal gallbladder physiology (HP:0012438)4.56578297
9Cholecystitis (HP:0001082)4.56578297
10Secondary amenorrhea (HP:0000869)4.28415793
11Osteomalacia (HP:0002749)4.27520847
12Chromsome breakage (HP:0040012)4.23373394
13Cerebral hypomyelination (HP:0006808)4.23113878
14Abdominal situs inversus (HP:0003363)4.10443481
15Abnormality of abdominal situs (HP:0011620)4.10443481
16Hypoplasia of the fovea (HP:0007750)4.09231198
17Aplasia/Hypoplasia of the fovea (HP:0008060)4.09231198
18Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01760468
19Facial hemangioma (HP:0000329)3.64948415
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.64411910
21Abnormality of the fovea (HP:0000493)3.54449874
22Impulsivity (HP:0100710)3.53991749
23Oligodactyly (hands) (HP:0001180)3.49213000
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.39914952
25Papillary thyroid carcinoma (HP:0002895)3.30028079
26Carpal bone hypoplasia (HP:0001498)3.26990783
27Absent radius (HP:0003974)3.26910921
28Shawl scrotum (HP:0000049)3.22921951
29Median cleft lip (HP:0000161)3.21536372
30Breast aplasia (HP:0100783)3.20664124
31Cortical dysplasia (HP:0002539)3.20210751
32Absent septum pellucidum (HP:0001331)3.18952060
33Aplasia/Hypoplasia of the breasts (HP:0010311)3.16037836
34Lip pit (HP:0100267)3.13196978
35Absent forearm bone (HP:0003953)3.11874570
36Aplasia involving forearm bones (HP:0009822)3.11874570
37Adrenal hypoplasia (HP:0000835)3.08107522
38Supernumerary spleens (HP:0009799)3.07397947
39Septo-optic dysplasia (HP:0100842)3.02417026
40Capillary hemangiomas (HP:0005306)2.97134008
41Oligodactyly (HP:0012165)2.93548767
42Flat capital femoral epiphysis (HP:0003370)2.93169120
43Sensory axonal neuropathy (HP:0003390)2.92868416
44Proximal tubulopathy (HP:0000114)2.92094239
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.91998566
46Degeneration of anterior horn cells (HP:0002398)2.84976862
47Abnormality of the anterior horn cell (HP:0006802)2.84976862
48Abnormality of the preputium (HP:0100587)2.81719733
49Abnormality of chromosome stability (HP:0003220)2.80048667
50Abnormality of the septum pellucidum (HP:0007375)2.79246178
51Abnormal lung lobation (HP:0002101)2.76110933
52Abnormality of lateral ventricle (HP:0030047)2.74632824
53Aplasia/Hypoplasia of the sternum (HP:0006714)2.72817062
54Insulin-resistant diabetes mellitus (HP:0000831)2.71755449
55* Male infertility (HP:0003251)2.68747907
56Meckel diverticulum (HP:0002245)2.67792153
57Urethral obstruction (HP:0000796)2.63691116
58CNS hypomyelination (HP:0003429)2.62650964
59Aplasia/Hypoplasia involving the musculature (HP:0001460)2.61157780
60Oral leukoplakia (HP:0002745)2.56160169
61Short tibia (HP:0005736)2.55245679
62Abnormal spermatogenesis (HP:0008669)2.54797696
63Gonadotropin excess (HP:0000837)2.53858039
64Chronic bronchitis (HP:0004469)2.52953163
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.52431516
66Abnormality of the ileum (HP:0001549)2.52429964
67Rhabdomyosarcoma (HP:0002859)2.52239287
68Personality changes (HP:0000751)2.51113924
69Rough bone trabeculation (HP:0100670)2.50081446
70Aplasia/Hypoplasia of the macula (HP:0008059)2.48160759
71Hyperglycinemia (HP:0002154)2.45728699
72Delusions (HP:0000746)2.44087977
73Small intestinal stenosis (HP:0012848)2.42058611
74Duodenal stenosis (HP:0100867)2.42058611
75Anterior segment dysgenesis (HP:0007700)2.41764933
76Abnormality of alanine metabolism (HP:0010916)2.41523758
77Hyperalaninemia (HP:0003348)2.41523758
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41523758
79Multiple enchondromatosis (HP:0005701)2.40492992
80Nephroblastoma (Wilms tumor) (HP:0002667)2.37603320
81Spinal muscular atrophy (HP:0007269)2.35222294
82Wrist flexion contracture (HP:0001239)2.33323145
83Abnormality of the clitoris (HP:0000056)2.32244851
84Horseshoe kidney (HP:0000085)2.31626780
85Sloping forehead (HP:0000340)2.31178120
86Aplasia/Hypoplasia of the tibia (HP:0005772)2.30731511
87* Infertility (HP:0000789)2.30218725
88Overlapping toe (HP:0001845)2.25662180
89Absent hand (HP:0004050)2.24757050
90Abnormality of the proximal phalanges of the hand (HP:0009834)2.24581874
91Aplasia/Hypoplasia affecting the retina (HP:0008061)2.24426942
92Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23765340
93Embryonal renal neoplasm (HP:0011794)2.22061914
94Unsteady gait (HP:0002317)2.21807617
95Short thumb (HP:0009778)2.21252257
96Microretrognathia (HP:0000308)2.21041104
97Ureteral duplication (HP:0000073)2.18411065
98Hypergonadotropic hypogonadism (HP:0000815)2.17681003
99Abnormality of chromosome segregation (HP:0002916)2.15932017
100Abnormality of midbrain morphology (HP:0002418)2.14718434
101Molar tooth sign on MRI (HP:0002419)2.14718434
102Pancreatic fibrosis (HP:0100732)2.13718080
103Abnormality of DNA repair (HP:0003254)2.12396667
104Irregular epiphyses (HP:0010582)2.10633475
105Renal Fanconi syndrome (HP:0001994)2.10078442
106Sandal gap (HP:0001852)2.08887751
107Ankle contracture (HP:0006466)2.08847176
108Abnormality of the labia (HP:0000058)2.08735658
109Hypokinesia (HP:0002375)2.05422659
110Posterior subcapsular cataract (HP:0007787)2.04971207
111Generalized aminoaciduria (HP:0002909)2.03787244
112Hyperglycemia (HP:0003074)2.03698624
113Muscle stiffness (HP:0003552)2.02998712
114Gaze-evoked nystagmus (HP:0000640)2.02414021
115Pulmonary fibrosis (HP:0002206)2.01357902
116Sparse lateral eyebrow (HP:0005338)2.00315729
117Azoospermia (HP:0000027)1.98931118
118Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.98299733
119Malnutrition (HP:0004395)1.97855759
120Ileus (HP:0002595)1.96542849
121Entropion (HP:0000621)1.95909512
122Myelodysplasia (HP:0002863)1.95298805
123Absent thumb (HP:0009777)1.95235421
124Fibular aplasia (HP:0002990)1.94181615
125Neoplasm of the oral cavity (HP:0100649)1.90089331
126Abnormal trabecular bone morphology (HP:0100671)1.90078642
127Rickets (HP:0002748)1.89691838
128Type 2 muscle fiber atrophy (HP:0003554)1.89024108
129Medial flaring of the eyebrow (HP:0010747)1.88960768
130Intrahepatic cholestasis (HP:0001406)1.88839757
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86423963
132Optic nerve hypoplasia (HP:0000609)1.86102716
133Bone marrow hypocellularity (HP:0005528)1.85861223
134Aplasia/Hypoplasia of the ulna (HP:0006495)1.85171765
135Hyperglycinuria (HP:0003108)1.84546080
136Skin pits (HP:0100276)1.84503574
137Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84150666
138Abnormality of the duodenum (HP:0002246)1.82894350
139Amniotic constriction ring (HP:0009775)1.81390913
140Abnormality of placental membranes (HP:0011409)1.81390913
141Pancreatic cysts (HP:0001737)1.80315460
142Slender long bone (HP:0003100)1.78026012
143Muscle fiber atrophy (HP:0100295)1.77645048
144Myokymia (HP:0002411)1.77142704
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77060281
146Rib fusion (HP:0000902)1.77040155
147Ectopic kidney (HP:0000086)1.75359556
148Tongue fasciculations (HP:0001308)1.75298211
149Cystic hygroma (HP:0000476)1.75296109
150Apathy (HP:0000741)1.75169729
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.74661072
152Medulloblastoma (HP:0002885)1.74331025
153Hypoplastic labia majora (HP:0000059)1.73898394
154Bile duct proliferation (HP:0001408)1.73749960
155Abnormal biliary tract physiology (HP:0012439)1.73749960
156Stenosis of the external auditory canal (HP:0000402)1.70079574
157Truncal obesity (HP:0001956)1.70018355
158Hypoglycemic coma (HP:0001325)1.69479898
159Facial cleft (HP:0002006)1.68389185
160Thyroid carcinoma (HP:0002890)1.66755897
161Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66628812
162Diminished motivation (HP:0000745)1.66046281
163Abnormality of the renal collecting system (HP:0004742)1.65938755
164Aplasia of the musculature (HP:0100854)1.65706990
165Choanal atresia (HP:0000453)1.65217972
166Preauricular pit (HP:0004467)1.64456225
167Periauricular skin pits (HP:0100277)1.64456225
168Poikiloderma (HP:0001029)1.64274741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.02622830
2MAP3K63.92684737
3PLK43.85996975
4MOS3.55568942
5TTK3.50965454
6LATS13.21294805
7BMPR23.16976084
8LATS23.16462299
9CDC72.99861911
10TAOK32.77898933
11STK38L2.70475497
12WEE12.43126684
13NEK22.41606702
14PLK12.32198151
15ERBB42.18929810
16MAP3K92.11306484
17ARAF2.03266875
18BRAF1.98226204
19NEK61.97735693
20PBK1.95677837
21CHEK21.78369546
22TRIM281.74337980
23KSR21.72595228
24EIF2AK11.68697039
25STK101.67990932
26MELK1.64877849
27RAF11.59098639
28NEK11.58313166
29PLK31.56135921
30ACVR1B1.55854179
31DYRK21.55174683
32CDK81.55173394
33STK31.52162421
34TNIK1.50755312
35MAP3K81.43635690
36AURKB1.36260548
37ZAK1.35694724
38MARK31.35530448
39MUSK1.30582927
40MST41.28403359
41BRSK21.18846711
42MAP3K131.17856934
43AURKA1.15898074
44MET1.15693413
45CDK191.11755691
46TAOK11.11301333
47SRPK11.09881718
48PRKD31.09642109
49CSNK1G11.06495014
50BMPR1B1.04013397
51TIE11.02607587
52PDK40.94565140
53PDK30.94565140
54TYRO30.93816483
55NUAK10.90355618
56CDK90.90167849
57CDK70.89382853
58BRSK10.87860218
59NTRK20.87366917
60CHEK10.85674832
61NLK0.85203853
62ABL20.83278371
63STK160.82988850
64STK380.82873185
65CSNK1G30.82188116
66AKT30.82058962
67PINK10.81538940
68PTK20.81159524
69EPHA40.77503521
70NTRK30.77357063
71CDK40.76655919
72PNCK0.72825662
73MAP4K20.72618022
74EEF2K0.71564149
75LMTK20.69383352
76DYRK30.67373804
77VRK10.65650590
78ATM0.63706377
79CSNK1G20.63249370
80ATR0.60686550
81EPHA20.60580528
82CCNB10.60078860
83PKN10.58808355
84PDK20.58720235
85PRKAA10.58519353
86CSNK1A1L0.58397420
87MKNK20.58195449
88CASK0.56864924
89TSSK60.55857766
90WNK30.55705220
91DMPK0.55396197
92CDK20.54178872
93PAK60.53736925
94MAPKAPK30.52724922
95MAP3K40.52719998
96TAF10.51691854
97CDK10.51116033
98EIF2AK30.50207789
99MAP3K50.44232253
100CDK30.43695916
101PAK10.43160915
102NME10.41784647
103WNK10.40205088
104BRD40.37582497
105CLK10.36187102
106KSR10.35473522
107TESK20.34377431
108STK240.34173976
109CSNK2A20.33846588
110PRKCZ0.32413309
111PRKCI0.31210865
112CSNK1E0.31167223
113MAP2K10.30029613
114FER0.28450056
115RPS6KA40.28272336
116PASK0.28261590
117GSK3B0.27779462
118TLK10.27644054
119TGFBR10.27615371
120STK390.26817747
121TNK20.26452316
122PIM10.26441672
123CDK120.25872295
124NEK90.23380954
125CAMK2A0.23121820
126CAMK1G0.22796116
127INSRR0.22296955
128STK40.22143377
129CSNK2A10.21771783
130PRKAA20.21282456
131RPS6KB20.20320207
132MAPK130.19351440
133ABL10.18427641
134PRKD20.17593210
135CSNK1A10.16840386
136EIF2AK20.16609001
137CSNK1D0.15382702
138MKNK10.15109711
139MAP2K70.13947717

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.34034102
2Cell cycle_Homo sapiens_hsa041104.06723282
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.91464887
4Basal transcription factors_Homo sapiens_hsa030223.91273995
5RNA polymerase_Homo sapiens_hsa030203.86032316
6RNA transport_Homo sapiens_hsa030133.45719899
7DNA replication_Homo sapiens_hsa030302.94040722
8RNA degradation_Homo sapiens_hsa030182.89033631
9Homologous recombination_Homo sapiens_hsa034402.69297916
10Base excision repair_Homo sapiens_hsa034102.68561328
11Oocyte meiosis_Homo sapiens_hsa041142.64819613
12Mismatch repair_Homo sapiens_hsa034302.63853952
13Fanconi anemia pathway_Homo sapiens_hsa034602.62228244
14Nucleotide excision repair_Homo sapiens_hsa034202.28056056
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.17912380
16p53 signaling pathway_Homo sapiens_hsa041152.17661044
17Circadian rhythm_Homo sapiens_hsa047102.11898427
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04251467
19Pyrimidine metabolism_Homo sapiens_hsa002402.02388952
20Ovarian steroidogenesis_Homo sapiens_hsa049131.87523822
21Folate biosynthesis_Homo sapiens_hsa007901.86561547
22Spliceosome_Homo sapiens_hsa030401.79659711
23Caffeine metabolism_Homo sapiens_hsa002321.79205463
24Proteasome_Homo sapiens_hsa030501.76576400
25Non-homologous end-joining_Homo sapiens_hsa034501.72061700
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.65824170
27Regulation of autophagy_Homo sapiens_hsa041401.57780174
28mRNA surveillance pathway_Homo sapiens_hsa030151.50224258
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.41321732
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40896028
31Linoleic acid metabolism_Homo sapiens_hsa005911.37362687
32Purine metabolism_Homo sapiens_hsa002301.34172697
33Fatty acid elongation_Homo sapiens_hsa000621.33881902
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.31903086
35Protein export_Homo sapiens_hsa030601.30278268
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26275968
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22685511
38Steroid biosynthesis_Homo sapiens_hsa001001.19380975
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17028720
40Ribosome_Homo sapiens_hsa030101.14711164
41Ether lipid metabolism_Homo sapiens_hsa005651.09626940
42TGF-beta signaling pathway_Homo sapiens_hsa043501.08547078
43One carbon pool by folate_Homo sapiens_hsa006701.04970050
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02432183
45Huntingtons disease_Homo sapiens_hsa050161.00561300
46Olfactory transduction_Homo sapiens_hsa047401.00150203
47Taste transduction_Homo sapiens_hsa047420.94711261
48Dorso-ventral axis formation_Homo sapiens_hsa043200.94085283
49Nicotine addiction_Homo sapiens_hsa050330.90565728
50MicroRNAs in cancer_Homo sapiens_hsa052060.88049427
51Phototransduction_Homo sapiens_hsa047440.85495627
52Pancreatic cancer_Homo sapiens_hsa052120.83451579
53Epstein-Barr virus infection_Homo sapiens_hsa051690.80878134
54Propanoate metabolism_Homo sapiens_hsa006400.79063625
55Biosynthesis of amino acids_Homo sapiens_hsa012300.72748620
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72448214
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72311456
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.72066364
59Hippo signaling pathway_Homo sapiens_hsa043900.65355547
60Cardiac muscle contraction_Homo sapiens_hsa042600.65127041
61Parkinsons disease_Homo sapiens_hsa050120.61517025
62mTOR signaling pathway_Homo sapiens_hsa041500.60479715
63FoxO signaling pathway_Homo sapiens_hsa040680.58962218
64Thyroid cancer_Homo sapiens_hsa052160.56508988
65Colorectal cancer_Homo sapiens_hsa052100.55943983
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54724350
67Pyruvate metabolism_Homo sapiens_hsa006200.53897674
68Pentose phosphate pathway_Homo sapiens_hsa000300.51790042
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51049706
70GnRH signaling pathway_Homo sapiens_hsa049120.49329697
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48128234
72HTLV-I infection_Homo sapiens_hsa051660.47300232
73Arachidonic acid metabolism_Homo sapiens_hsa005900.45484871
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45386769
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43417542
76GABAergic synapse_Homo sapiens_hsa047270.42015774
77Choline metabolism in cancer_Homo sapiens_hsa052310.41771260
78ABC transporters_Homo sapiens_hsa020100.41196841
79Arginine and proline metabolism_Homo sapiens_hsa003300.40778745
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.40326557
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39528420
82Oxidative phosphorylation_Homo sapiens_hsa001900.38480229
83Synaptic vesicle cycle_Homo sapiens_hsa047210.38168003
84Sphingolipid metabolism_Homo sapiens_hsa006000.38017425
85Renal cell carcinoma_Homo sapiens_hsa052110.36574972
86Gap junction_Homo sapiens_hsa045400.36408416
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36199574
88Viral carcinogenesis_Homo sapiens_hsa052030.35985563
89Mineral absorption_Homo sapiens_hsa049780.35949091
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34461063
91Herpes simplex infection_Homo sapiens_hsa051680.32169556
92Selenocompound metabolism_Homo sapiens_hsa004500.31316203
93Prolactin signaling pathway_Homo sapiens_hsa049170.30954242
94Glutathione metabolism_Homo sapiens_hsa004800.29759343
95Small cell lung cancer_Homo sapiens_hsa052220.28244028
96Serotonergic synapse_Homo sapiens_hsa047260.27112815
97Morphine addiction_Homo sapiens_hsa050320.26909918
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26483418
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23300222
100Collecting duct acid secretion_Homo sapiens_hsa049660.22917135
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22362726
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21723314
103Insulin secretion_Homo sapiens_hsa049110.21269672
104Lysine degradation_Homo sapiens_hsa003100.21100246
105Notch signaling pathway_Homo sapiens_hsa043300.20555740
106Bile secretion_Homo sapiens_hsa049760.19377873
107Adherens junction_Homo sapiens_hsa045200.19309503
108Metabolic pathways_Homo sapiens_hsa011000.18510261
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18489729
110Other glycan degradation_Homo sapiens_hsa005110.18104962
111beta-Alanine metabolism_Homo sapiens_hsa004100.16728553
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16333278
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16045599
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15753235
115Butanoate metabolism_Homo sapiens_hsa006500.15614666
116Vitamin digestion and absorption_Homo sapiens_hsa049770.15523016
117Tight junction_Homo sapiens_hsa045300.15114160
118Long-term depression_Homo sapiens_hsa047300.15095837
119Fructose and mannose metabolism_Homo sapiens_hsa000510.15093870
120Hedgehog signaling pathway_Homo sapiens_hsa043400.14018615
121Prostate cancer_Homo sapiens_hsa052150.12801906
122Bladder cancer_Homo sapiens_hsa052190.11770561
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10584202
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08414866
125Retinol metabolism_Homo sapiens_hsa008300.07744731
126Ras signaling pathway_Homo sapiens_hsa040140.07455458
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07098958
128VEGF signaling pathway_Homo sapiens_hsa043700.06727160
129Estrogen signaling pathway_Homo sapiens_hsa049150.06443660
130Sulfur relay system_Homo sapiens_hsa041220.06067957
131Pathways in cancer_Homo sapiens_hsa052000.05751747
132Glycerolipid metabolism_Homo sapiens_hsa005610.05555979
133Arginine biosynthesis_Homo sapiens_hsa002200.05421175
134Inositol phosphate metabolism_Homo sapiens_hsa005620.05170167
135Hepatitis B_Homo sapiens_hsa051610.04114274
136Wnt signaling pathway_Homo sapiens_hsa043100.02870479
137Shigellosis_Homo sapiens_hsa051310.01900805
138AMPK signaling pathway_Homo sapiens_hsa041520.01859820
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.01547649
140Glucagon signaling pathway_Homo sapiens_hsa049220.01253337
141Endometrial cancer_Homo sapiens_hsa052130.00105620

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