AVEN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)6.22154040
2piRNA metabolic process (GO:0034587)6.07595416
3fusion of sperm to egg plasma membrane (GO:0007342)5.64715268
4sperm-egg recognition (GO:0035036)5.59102576
5axonemal dynein complex assembly (GO:0070286)5.55587819
6motile cilium assembly (GO:0044458)5.49216857
7cell wall macromolecule metabolic process (GO:0044036)5.43115873
8cell wall macromolecule catabolic process (GO:0016998)5.43115873
9sperm motility (GO:0030317)5.37085615
10DNA deamination (GO:0045006)5.35824745
11cilium or flagellum-dependent cell motility (GO:0001539)5.31774884
12male meiosis (GO:0007140)5.08308908
13epithelial cilium movement (GO:0003351)5.05958019
14binding of sperm to zona pellucida (GO:0007339)5.05355755
15cell-cell recognition (GO:0009988)4.93235270
16reproduction (GO:0000003)4.88381472
17acrosome assembly (GO:0001675)4.82695605
18microtubule depolymerization (GO:0007019)4.76017924
19regulation of cilium movement (GO:0003352)4.52771224
20spermatid development (GO:0007286)4.50903705
21DNA methylation involved in gamete generation (GO:0043046)4.42988575
22acrosome reaction (GO:0007340)4.39925623
23protein K6-linked ubiquitination (GO:0085020)4.39758424
24single fertilization (GO:0007338)4.21640486
25plasma membrane fusion (GO:0045026)4.17117010
26cilium movement (GO:0003341)4.14391361
27maturation of 5.8S rRNA (GO:0000460)4.04770621
28meiotic cell cycle (GO:0051321)3.93853765
29meiotic chromosome segregation (GO:0045132)3.90699922
30mitotic chromosome condensation (GO:0007076)3.89853708
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84663078
32paraxial mesoderm development (GO:0048339)3.79050582
33endodermal cell differentiation (GO:0035987)3.78953439
34synaptonemal complex assembly (GO:0007130)3.77021450
35male meiosis I (GO:0007141)3.75675910
36synaptonemal complex organization (GO:0070193)3.71443848
37regulation of response to tumor cell (GO:0002834)3.67988449
38positive regulation of response to tumor cell (GO:0002836)3.67988449
39positive regulation of immune response to tumor cell (GO:0002839)3.67988449
40regulation of immune response to tumor cell (GO:0002837)3.67988449
41formation of translation preinitiation complex (GO:0001731)3.64346641
42mitotic metaphase plate congression (GO:0007080)3.63444804
43fertilization (GO:0009566)3.62702707
44chromatin remodeling at centromere (GO:0031055)3.56543796
45protein maturation by protein folding (GO:0022417)3.51930830
46histone exchange (GO:0043486)3.48956934
47meiotic nuclear division (GO:0007126)3.44081697
48single strand break repair (GO:0000012)3.42355041
49maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.41661230
50CENP-A containing nucleosome assembly (GO:0034080)3.40307565
51kinetochore assembly (GO:0051382)3.37852695
52chromosome organization involved in meiosis (GO:0070192)3.37631671
53replication fork processing (GO:0031297)3.30656372
54male gamete generation (GO:0048232)3.28753081
55spermatogenesis (GO:0007283)3.28476620
56cellular protein complex localization (GO:0034629)3.23689610
57sperm capacitation (GO:0048240)3.22037198
58nucleobase-containing small molecule interconversion (GO:0015949)3.22002481
59kinetochore organization (GO:0051383)3.20064044
60gamete generation (GO:0007276)3.19396343
61meiosis I (GO:0007127)3.19348943
62protein localization to chromosome, centromeric region (GO:0071459)3.17262040
63skin morphogenesis (GO:0043589)3.16954399
64centriole assembly (GO:0098534)3.16608239
65DNA replication checkpoint (GO:0000076)3.16253362
66chaperone-mediated protein transport (GO:0072321)3.14387879
67hemidesmosome assembly (GO:0031581)3.12397889
68establishment of integrated proviral latency (GO:0075713)3.12357268
69GTP biosynthetic process (GO:0006183)3.10833781
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.10820181
71ribosomal small subunit assembly (GO:0000028)3.10786104
72regulation of meiosis I (GO:0060631)3.08969954
73cell-substrate junction assembly (GO:0007044)3.08167032
74ribosomal large subunit biogenesis (GO:0042273)3.08043865
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.06468121
76monoubiquitinated protein deubiquitination (GO:0035520)3.05694104
77rRNA modification (GO:0000154)3.05357963
78ribosomal small subunit biogenesis (GO:0042274)3.04866559
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.04809325
80cell adhesion mediated by integrin (GO:0033627)3.03882958
81meiotic cell cycle process (GO:1903046)3.01983682
82heterochromatin organization (GO:0070828)3.01330127
83DNA replication initiation (GO:0006270)3.00866223
84telomere maintenance via semi-conservative replication (GO:0032201)2.99035737
85cotranslational protein targeting to membrane (GO:0006613)2.97871150
86protein targeting to ER (GO:0045047)2.97800426
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96633562
88mitotic sister chromatid segregation (GO:0000070)2.96627073
89metaphase plate congression (GO:0051310)2.95540513
90establishment of protein localization to endoplasmic reticulum (GO:0072599)2.95501718
91maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95176729
92DNA replication-independent nucleosome assembly (GO:0006336)2.94343170
93DNA replication-independent nucleosome organization (GO:0034724)2.94343170
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93920358
95UTP biosynthetic process (GO:0006228)2.92841141
96proteasome assembly (GO:0043248)2.92802028
97reciprocal meiotic recombination (GO:0007131)2.91691987
98reciprocal DNA recombination (GO:0035825)2.91691987
99rRNA processing (GO:0006364)2.91567368
100base-excision repair, AP site formation (GO:0006285)2.89198672
101telomere maintenance via recombination (GO:0000722)2.88220507
102rRNA metabolic process (GO:0016072)2.87232186
103DNA strand elongation involved in DNA replication (GO:0006271)2.85812737
104regulation of translational fidelity (GO:0006450)2.85642699
105focal adhesion assembly (GO:0048041)2.85481132
106cell-substrate adherens junction assembly (GO:0007045)2.85481132
107germ cell development (GO:0007281)2.85409314
108nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85011973
109stress fiber assembly (GO:0043149)2.84854834
110translational initiation (GO:0006413)2.84748517
111regulation of spindle checkpoint (GO:0090231)2.84365559
112protein retention in ER lumen (GO:0006621)2.81631969
113ribonucleoprotein complex biogenesis (GO:0022613)2.81437385
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.79691511
115mismatch repair (GO:0006298)2.79663896
116response to redox state (GO:0051775)2.78307515
117protein localization to endoplasmic reticulum (GO:0070972)2.77810350
118mitotic sister chromatid cohesion (GO:0007064)2.77340470
119protein localization to kinetochore (GO:0034501)2.76636873
120synapsis (GO:0007129)2.76103408
121viral transcription (GO:0019083)2.76011269
122translational termination (GO:0006415)2.74693593
123translational elongation (GO:0006414)2.73626236
124rRNA methylation (GO:0031167)2.73380155
125establishment of chromosome localization (GO:0051303)2.73347276
126adherens junction assembly (GO:0034333)2.72097671
127DNA strand elongation (GO:0022616)2.72090813
128ribosome biogenesis (GO:0042254)2.70102583
129sister chromatid cohesion (GO:0007062)2.68010070
130maturation of SSU-rRNA (GO:0030490)2.67780043
131epithelial cell-cell adhesion (GO:0090136)2.67427863
132nucleotide-excision repair, DNA gap filling (GO:0006297)2.67396889
133collagen fibril organization (GO:0030199)2.67267108
134viral life cycle (GO:0019058)2.67024814
135ventricular cardiac muscle cell development (GO:0055015)2.66881048
136chromosome condensation (GO:0030261)2.66760701
137DNA double-strand break processing (GO:0000729)2.66481653
138cellular process involved in reproduction in multicellular organism (GO:0022412)2.66391842
139pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66277930
140Golgi transport vesicle coating (GO:0048200)2.65878787
141COPI coating of Golgi vesicle (GO:0048205)2.65878787
142ribosome assembly (GO:0042255)2.65314934
143negative regulation of stem cell proliferation (GO:2000647)2.62862857
144regulation of early endosome to late endosome transport (GO:2000641)2.62837511
145endothelial cell morphogenesis (GO:0001886)2.62314222
146pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.61978278
147protein complex localization (GO:0031503)2.61821196
148DNA packaging (GO:0006323)2.60965411
149regulation of translational termination (GO:0006449)2.59235430
150cellular protein complex disassembly (GO:0043624)2.57793028
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57097305
152negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.55971798
153regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54431754
154chondrocyte proliferation (GO:0035988)2.49362269
155wound healing, spreading of epidermal cells (GO:0035313)2.49143613
156translation (GO:0006412)2.48159823
157L-alpha-amino acid transmembrane transport (GO:1902475)2.47506370
158DNA unwinding involved in DNA replication (GO:0006268)2.44343521
159hyaluronan catabolic process (GO:0030214)2.41072918
160regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39735850
161establishment of viral latency (GO:0019043)2.38037480
162protein targeting to membrane (GO:0006612)2.35049465
163hypotonic response (GO:0006971)2.34883482
164nuclear pore organization (GO:0006999)2.34868641
165bone trabecula formation (GO:0060346)2.34367009
166IMP metabolic process (GO:0046040)2.34349256
167positive regulation of blood vessel endothelial cell migration (GO:0043536)2.32739957
168protein localization to endosome (GO:0036010)2.32513813
169kidney mesenchyme development (GO:0072074)2.32448642
170regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.31194295
171folic acid-containing compound biosynthetic process (GO:0009396)2.30358474
172nuclear envelope reassembly (GO:0031468)2.29977930
173mitotic nuclear envelope reassembly (GO:0007084)2.29977930
174nuclear pore complex assembly (GO:0051292)2.29142340
175nucleotide-sugar biosynthetic process (GO:0009226)2.28014395
176cellular component biogenesis (GO:0044085)2.27712414
177peptidyl-proline hydroxylation (GO:0019511)2.26808117
178cochlea morphogenesis (GO:0090103)2.25548000
179negative regulation of chondrocyte differentiation (GO:0032331)2.25294785
180retina vasculature morphogenesis in camera-type eye (GO:0061299)2.25165893
181regulation of mitochondrial translation (GO:0070129)2.24536663
182actin-myosin filament sliding (GO:0033275)2.24107172
183muscle filament sliding (GO:0030049)2.24107172
184basement membrane organization (GO:0071711)2.23888404
185pinocytosis (GO:0006907)2.22431112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.63102366
2E2F7_22180533_ChIP-Seq_HELA_Human5.36087922
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.53946352
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.36248293
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34902047
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.09891267
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.03065143
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99927558
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89620549
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80320265
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78713822
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.73615974
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.68212469
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.57679128
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53099603
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.52556769
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50927138
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43451621
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39581868
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18651668
21KAP1_22055183_ChIP-Seq_ESCs_Mouse2.17059715
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.15771060
23* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.15275585
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.06571474
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06252224
26ZNF263_19887448_ChIP-Seq_K562_Human2.05226188
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05133027
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00405816
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97298607
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.96475805
31* NOTCH1_21737748_ChIP-Seq_TLL_Human1.88929979
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88306606
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.88225495
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87901415
35CLOCK_20551151_ChIP-Seq_293T_Human1.86850127
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.84143877
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83864338
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77904999
39VDR_23849224_ChIP-Seq_CD4+_Human1.77551047
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76924442
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.74104564
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73106832
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72696219
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.70217254
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67816439
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67130134
47MYC_18940864_ChIP-ChIP_HL60_Human1.67019404
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.64285096
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63873641
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62895214
51IRF1_19129219_ChIP-ChIP_H3396_Human1.62792675
52FOXP3_21729870_ChIP-Seq_TREG_Human1.62510748
53VDR_22108803_ChIP-Seq_LS180_Human1.61254204
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60902454
55* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59778235
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58833155
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57888178
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56396018
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54671345
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53913399
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49678984
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47597915
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.46146847
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45433891
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.43256328
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41055435
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.40936101
68DCP1A_22483619_ChIP-Seq_HELA_Human1.39849379
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38412150
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36520091
71MYC_22102868_ChIP-Seq_BL_Human1.36063443
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35689463
73NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34939710
74ATF3_27146783_Chip-Seq_COLON_Human1.34309055
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33865082
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30991908
77TTF2_22483619_ChIP-Seq_HELA_Human1.29428445
78* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29125103
79* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28110142
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.27945554
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26715087
82BRD4_25478319_ChIP-Seq_HGPS_Human1.25723566
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25026886
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.24910643
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.24847515
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24419124
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23181893
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22525173
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22492788
90* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20134405
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.19913819
92* GABP_19822575_ChIP-Seq_HepG2_Human1.19612325
93KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18982166
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18947325
95CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18506522
96RACK7_27058665_Chip-Seq_MCF-7_Human1.18474105
97* OCT4_18555785_Chip-Seq_ESCs_Mouse1.16875924
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.16768882
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16554309
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16258622
101STAT1_17558387_ChIP-Seq_HELA_Human1.15696133
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14922229
103* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14887735
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14319966
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.13710512
106CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13330516
107* STAT3_18555785_Chip-Seq_ESCs_Mouse1.13059310
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13000164
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12678326
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11971677
111TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.11453242
112* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10363136
113* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10034660
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09754335
115* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09357147
116AR_21909140_ChIP-Seq_LNCAP_Human1.09092053
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.08715984
118* KLF4_18555785_Chip-Seq_ESCs_Mouse1.08567418
119* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08455559
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07639088
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07639088
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07639088
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07609796
124MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07273052
125CHD1_26751641_Chip-Seq_LNCaP_Human1.06781535
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06196197
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06117170
128* NMYC_18555785_Chip-Seq_ESCs_Mouse1.05746697
129GATA3_21867929_ChIP-Seq_CD8_Mouse1.05241537
130ELK1_19687146_ChIP-ChIP_HELA_Human1.04779534
131NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04518625
132RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04359778
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04350466
134CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03371586
135* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03311128
136* P300_18555785_Chip-Seq_ESCs_Mouse1.03092082
137UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02838490
138TFEB_21752829_ChIP-Seq_HELA_Human1.02550287
139GATA3_21867929_ChIP-Seq_TH1_Mouse1.02440343
140ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01772564
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01341815
142* ZFX_18555785_Chip-Seq_ESCs_Mouse1.00959056
143WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00594452
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00464721
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99631822
146OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99530643
147SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98781070
148* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98484196
149* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98484196
150* P53_22387025_ChIP-Seq_ESCs_Mouse0.98291854
151* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98280712
152* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95022046
153CRX_20693478_ChIP-Seq_RETINA_Mouse0.94780806
154* CTCF_18555785_Chip-Seq_ESCs_Mouse0.94037764
155HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93900544
156XRN2_22483619_ChIP-Seq_HELA_Human0.91792261
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91648722
158* SOX2_18555785_Chip-Seq_ESCs_Mouse0.91522258
159E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90548980
160* CMYC_18555785_Chip-Seq_ESCs_Mouse0.88540905
161RNF2_27304074_Chip-Seq_NSC_Mouse0.87962672
162* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87962534
163* TAL1_26923725_Chip-Seq_HPCs_Mouse0.87693908
164CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87528470
165SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86184119
166* E2F1_18555785_Chip-Seq_ESCs_Mouse0.85882515
167WDR5_24793694_ChIP-Seq_LNCAP_Human0.85768188
168OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84625531
169HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84586756
170SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84388747
171STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84288560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.14515137
2MP0008438_abnormal_cutaneous_collagen5.17832244
3MP0003705_abnormal_hypodermis_morpholog4.33677824
4MP0003693_abnormal_embryo_hatching3.96235955
5MP0001929_abnormal_gametogenesis3.48136549
6MP0008057_abnormal_DNA_replication3.46529230
7MP0010094_abnormal_chromosome_stability3.43907287
8MP0008877_abnormal_DNA_methylation3.38630770
9MP0003111_abnormal_nucleus_morphology3.29651954
10MP0004272_abnormal_basement_membrane3.16868860
11MP0003718_maternal_effect3.09304150
12MP0008058_abnormal_DNA_repair3.06045938
13MP0003698_abnormal_male_reproductive3.02812665
14MP0006292_abnormal_olfactory_placode2.94287092
15MP0004957_abnormal_blastocyst_morpholog2.88342556
16MP0003566_abnormal_cell_adhesion2.77150630
17MP0002210_abnormal_sex_determination2.64800164
18MP0002102_abnormal_ear_morphology2.50656120
19MP0003646_muscle_fatigue2.46783055
20MP0003077_abnormal_cell_cycle2.46299780
21MP0005451_abnormal_body_composition2.44870711
22MP0010030_abnormal_orbit_morphology2.39369867
23MP0005623_abnormal_meninges_morphology2.30532969
24MP0001145_abnormal_male_reproductive2.20194716
25MP0005257_abnormal_intraocular_pressure2.19338235
26MP0004233_abnormal_muscle_weight2.19107846
27MP0000653_abnormal_sex_gland2.16156044
28MP0010368_abnormal_lymphatic_system2.15973752
29MP0005275_abnormal_skin_tensile2.09463977
30MP0003279_aneurysm2.07770222
31MP0003136_yellow_coat_color2.00659840
32MP0002877_abnormal_melanocyte_morpholog1.99914705
33MP0008932_abnormal_embryonic_tissue1.97208009
34MP0002161_abnormal_fertility/fecundity1.92324400
35MP0002132_abnormal_respiratory_system1.85606879
36MP0009384_cardiac_valve_regurgitation1.84131320
37MP0010352_gastrointestinal_tract_polyps1.82856210
38MP0003763_abnormal_thymus_physiology1.78963350
39MP0004381_abnormal_hair_follicle1.76922707
40MP0003786_premature_aging1.76909447
41MP0008007_abnormal_cellular_replicative1.75793363
42MP0009053_abnormal_anal_canal1.75045774
43MP0000490_abnormal_crypts_of1.74146120
44MP0000749_muscle_degeneration1.71711882
45MP0005023_abnormal_wound_healing1.68305703
46MP0000762_abnormal_tongue_morphology1.68074484
47MP0005075_abnormal_melanosome_morpholog1.65021149
48MP0002060_abnormal_skin_morphology1.58685847
49MP0000751_myopathy1.58575422
50MP0002653_abnormal_ependyma_morphology1.58071483
51MP0000015_abnormal_ear_pigmentation1.56536973
52MP0009250_abnormal_appendicular_skeleto1.54120288
53MP0001119_abnormal_female_reproductive1.53371628
54MP0005503_abnormal_tendon_morphology1.52727915
55MP0001958_emphysema1.49097946
56MP0000750_abnormal_muscle_regeneration1.48696681
57MP0002796_impaired_skin_barrier1.48333779
58MP0000733_abnormal_muscle_development1.45446875
59MP0009379_abnormal_foot_pigmentation1.43216679
60MP0000759_abnormal_skeletal_muscle1.41788946
61MP0000767_abnormal_smooth_muscle1.37055290
62MP0001188_hyperpigmentation1.36113056
63MP0001542_abnormal_bone_strength1.29312582
64MP0005174_abnormal_tail_pigmentation1.28858224
65MP0004087_abnormal_muscle_fiber1.27763582
66MP0003699_abnormal_female_reproductive1.26975347
67MP0005501_abnormal_skin_physiology1.26517539
68MP0004084_abnormal_cardiac_muscle1.25062080
69MP0001299_abnormal_eye_distance/1.23226437
70MP0002249_abnormal_larynx_morphology1.20835542
71MP0005076_abnormal_cell_differentiation1.20489800
72MP0005395_other_phenotype1.16616911
73MP0002160_abnormal_reproductive_system1.16387093
74MP0005389_reproductive_system_phenotype1.14462125
75MP0003091_abnormal_cell_migration1.10602345
76MP0002396_abnormal_hematopoietic_system1.09278056
77MP0000428_abnormal_craniofacial_morphol1.09138071
78MP0002254_reproductive_system_inflammat1.08473171
79MP0002019_abnormal_tumor_incidence1.07633365
80MP0000747_muscle_weakness1.07189054
81MP0002277_abnormal_respiratory_mucosa1.06094486
82MP0008260_abnormal_autophagy1.04610106
83MP0009697_abnormal_copulation1.03544489
84MP0002138_abnormal_hepatobiliary_system1.03146676
85MP0003941_abnormal_skin_development1.02716004
86MP0002697_abnormal_eye_size1.00598469
87MP0001919_abnormal_reproductive_system1.00539617
88MP0001879_abnormal_lymphatic_vessel1.00234090
89MP0002269_muscular_atrophy1.00014638
90MP0005508_abnormal_skeleton_morphology0.99386582
91MP0003315_abnormal_perineum_morphology0.99095611
92MP0004036_abnormal_muscle_relaxation0.99012072
93MP0003453_abnormal_keratinocyte_physiol0.96964537
94MP0001849_ear_inflammation0.96495153
95MP0000534_abnormal_ureter_morphology0.96460137
96MP0001243_abnormal_dermal_layer0.96161799
97MP0001545_abnormal_hematopoietic_system0.96004052
98MP0005397_hematopoietic_system_phenotyp0.96004052
99MP0009333_abnormal_splenocyte_physiolog0.95906570
100MP0000703_abnormal_thymus_morphology0.95424979
101MP0002398_abnormal_bone_marrow0.95344257
102MP0000566_synostosis0.95075200
103MP0005330_cardiomyopathy0.95063792
104MP0005197_abnormal_uvea_morphology0.94671724
105MP0009840_abnormal_foam_cell0.93966031
106MP0003984_embryonic_growth_retardation0.93906598
107MP0001915_intracranial_hemorrhage0.92738521
108MP0003950_abnormal_plasma_membrane0.90996646
109MP0000467_abnormal_esophagus_morphology0.90842517
110MP0005670_abnormal_white_adipose0.89550499
111MP0004858_abnormal_nervous_system0.89484085
112MP0000678_abnormal_parathyroid_gland0.87430741
113MP0010630_abnormal_cardiac_muscle0.87346510
114MP0004185_abnormal_adipocyte_glucose0.87263320
115MP0003755_abnormal_palate_morphology0.86946947
116MP0002088_abnormal_embryonic_growth/wei0.86399460
117MP0000313_abnormal_cell_death0.86252079
118MP0000350_abnormal_cell_proliferation0.86012191
119MP0003183_abnormal_peptide_metabolism0.85789262
120MP0008995_early_reproductive_senescence0.85601537
121MP0000689_abnormal_spleen_morphology0.85360615
122MP0005671_abnormal_response_to0.85151627
123MP0002896_abnormal_bone_mineralization0.84910078
124MP0001881_abnormal_mammary_gland0.81262494
125MP0002722_abnormal_immune_system0.80834298
126MP0001764_abnormal_homeostasis0.80381731
127MP0001348_abnormal_lacrimal_gland0.79967324
128MP0003385_abnormal_body_wall0.79618349
129MP0005193_abnormal_anterior_eye0.79583771
130MP0002086_abnormal_extraembryonic_tissu0.78850613
131MP0002095_abnormal_skin_pigmentation0.78573969
132MP0009672_abnormal_birth_weight0.77752375
133MP0003868_abnormal_feces_composition0.77698900
134MP0002127_abnormal_cardiovascular_syste0.77618005
135MP0001672_abnormal_embryogenesis/_devel0.77611649
136MP0005380_embryogenesis_phenotype0.77611649
137MP0004808_abnormal_hematopoietic_stem0.76253885
138MP0003942_abnormal_urinary_system0.75643914
139MP0002085_abnormal_embryonic_tissue0.75132787
140MP0000716_abnormal_immune_system0.74912399
141MP0000462_abnormal_digestive_system0.74698672
142MP0001873_stomach_inflammation0.74670496
143MP0000627_abnormal_mammary_gland0.74460719
144MP0005621_abnormal_cell_physiology0.74426370
145MP0000579_abnormal_nail_morphology0.72989258
146MP0002163_abnormal_gland_morphology0.72798775
147MP0002092_abnormal_eye_morphology0.72743026
148MP0004197_abnormal_fetal_growth/weight/0.72584061
149MP0003186_abnormal_redox_activity0.71928766
150MP0001730_embryonic_growth_arrest0.71763327
151MP0001697_abnormal_embryo_size0.71485193
152MP0001835_abnormal_antigen_presentation0.71196078
153MP0002429_abnormal_blood_cell0.69441403
154MP0001800_abnormal_humoral_immune0.69175421
155MP0004019_abnormal_vitamin_homeostasis0.68148851
156MP0003123_paternal_imprinting0.67430063
157MP0005647_abnormal_sex_gland0.67360976
158MP0002405_respiratory_system_inflammati0.66912934
159MP0002420_abnormal_adaptive_immunity0.66248776
160MP0000613_abnormal_salivary_gland0.65917127
161MP0001819_abnormal_immune_cell0.65373586
162MP0005310_abnormal_salivary_gland0.64512548
163MP0002723_abnormal_immune_serum0.63684127
164MP0002452_abnormal_antigen_presenting0.60042859
165MP0006036_abnormal_mitochondrial_physio0.59537985
166MP0002080_prenatal_lethality0.58364511
167MP0002282_abnormal_trachea_morphology0.58159071
168MP0002084_abnormal_developmental_patter0.56077007
169MP0001529_abnormal_vocalization0.54691567
170MP0000685_abnormal_immune_system0.53381628
171MP0003938_abnormal_ear_development0.52843280
172MP0003937_abnormal_limbs/digits/tail_de0.52243064
173MP0003011_delayed_dark_adaptation0.51130189

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.31707861
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.41831734
3Absent/shortened dynein arms (HP:0200106)6.41831734
4Premature rupture of membranes (HP:0001788)6.22350122
5Protrusio acetabuli (HP:0003179)5.39299288
6Abnormal respiratory motile cilium physiology (HP:0012261)5.27115744
7Abnormal respiratory motile cilium morphology (HP:0005938)4.92631784
8Abnormal respiratory epithelium morphology (HP:0012253)4.92631784
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.41754235
10Abnormal ciliary motility (HP:0012262)4.19713263
11Rhinitis (HP:0012384)4.14372266
12Chromsome breakage (HP:0040012)4.11665016
13Chronic bronchitis (HP:0004469)4.03150320
14Type 1 muscle fiber predominance (HP:0003803)4.01537688
15Infertility (HP:0000789)3.74791062
16Ankle contracture (HP:0006466)3.74730520
17Nemaline bodies (HP:0003798)3.52148928
18Reticulocytopenia (HP:0001896)3.43406755
19Male infertility (HP:0003251)3.43203671
20Fragile skin (HP:0001030)3.38303997
21Spinal rigidity (HP:0003306)3.35386786
22Abnormality of the preputium (HP:0100587)3.32523551
23Birth length less than 3rd percentile (HP:0003561)3.32294802
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.31099947
25Nasal polyposis (HP:0100582)3.22962300
26Breast hypoplasia (HP:0003187)3.21999853
27Muscle fiber inclusion bodies (HP:0100299)3.15307299
28Aortic dissection (HP:0002647)3.13115172
29Aplasia/Hypoplasia of the uvula (HP:0010293)3.12959197
30Atrophic scars (HP:0001075)3.10284971
31Bronchiectasis (HP:0002110)3.07931369
32Abnormality of the ileum (HP:0001549)3.00739222
33Abnormal spermatogenesis (HP:0008669)3.00436699
34Meckel diverticulum (HP:0002245)2.99979813
35Bladder diverticulum (HP:0000015)2.98820820
36Duplicated collecting system (HP:0000081)2.93409422
37Aortic aneurysm (HP:0004942)2.90271734
38Nephronophthisis (HP:0000090)2.89413296
39Impulsivity (HP:0100710)2.88773254
40Abnormality of DNA repair (HP:0003254)2.81437815
41Abnormality of dentin (HP:0010299)2.81321425
42Abnormal number of erythroid precursors (HP:0012131)2.80013831
43Abnormality of chromosome stability (HP:0003220)2.79804321
44Absent thumb (HP:0009777)2.78763765
45Vascular tortuosity (HP:0004948)2.78257069
46Soft skin (HP:0000977)2.77001065
47Abnormality of cells of the erythroid lineage (HP:0012130)2.71083153
48Supernumerary spleens (HP:0009799)2.67745509
49Vertebral compression fractures (HP:0002953)2.67220226
50Genu recurvatum (HP:0002816)2.63099224
51Premature ovarian failure (HP:0008209)2.61836623
52Achilles tendon contracture (HP:0001771)2.61824605
53Clubbing of toes (HP:0100760)2.61272520
54Progressive muscle weakness (HP:0003323)2.60845241
55Type 2 muscle fiber atrophy (HP:0003554)2.60628604
56Generalized amyotrophy (HP:0003700)2.60624096
57Recurrent sinusitis (HP:0011108)2.59766952
58Slender build (HP:0001533)2.58413333
59Elbow flexion contracture (HP:0002987)2.58135785
60Increased connective tissue (HP:0009025)2.57922920
61Abnormality of skeletal muscle fiber size (HP:0012084)2.57490627
62Trismus (HP:0000211)2.57076786
63Bronchitis (HP:0012387)2.53976726
64Round ear (HP:0100830)2.53462323
65Blue sclerae (HP:0000592)2.52046081
66Arterial tortuosity (HP:0005116)2.50668777
67Shallow orbits (HP:0000586)2.49106434
68Tubulointerstitial nephritis (HP:0001970)2.48045362
69Increased variability in muscle fiber diameter (HP:0003557)2.46329324
70Selective tooth agenesis (HP:0001592)2.45005321
71Azoospermia (HP:0000027)2.44481396
72Distal lower limb muscle weakness (HP:0009053)2.44286369
73Wormian bones (HP:0002645)2.44107015
74Absent radius (HP:0003974)2.43729664
75Muscle fiber atrophy (HP:0100295)2.43018278
76Abnormality of the renal collecting system (HP:0004742)2.42669366
77Abnormality of the nasal mucosa (HP:0000433)2.39014121
78Mitral regurgitation (HP:0001653)2.37725928
79Pallor (HP:0000980)2.28811965
80Abnormality of the Achilles tendon (HP:0005109)2.28806513
81Small intestinal stenosis (HP:0012848)2.28734253
82Duodenal stenosis (HP:0100867)2.28734253
83Spondylolisthesis (HP:0003302)2.26406500
84Short nail (HP:0001799)2.25832704
85Aplasia involving forearm bones (HP:0009822)2.25067087
86Absent forearm bone (HP:0003953)2.25067087
87Abnormality of the renal medulla (HP:0100957)2.24563806
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.24330138
89Cervical subluxation (HP:0003308)2.23225706
90Triphalangeal thumb (HP:0001199)2.21237248
91Mildly elevated creatine phosphokinase (HP:0008180)2.20937959
92Myelodysplasia (HP:0002863)2.17466746
93Macrocytic anemia (HP:0001972)2.17316813
94Bowel diverticulosis (HP:0005222)2.17306498
95Hyperacusis (HP:0010780)2.16178283
96Aplastic anemia (HP:0001915)2.16165352
97Mitral valve prolapse (HP:0001634)2.15605513
98Abnormality of lateral ventricle (HP:0030047)2.13685055
99Distal lower limb amyotrophy (HP:0008944)2.12968791
100Osteolytic defects of the hand bones (HP:0009699)2.10719045
101Osteolytic defects of the phalanges of the hand (HP:0009771)2.10719045
102Pancytopenia (HP:0001876)2.09755543
103Bone marrow hypocellularity (HP:0005528)2.09121285
104Ectopic kidney (HP:0000086)2.06862276
105Hydroureter (HP:0000072)2.06054718
106Abnormality of midbrain morphology (HP:0002418)2.05428841
107Molar tooth sign on MRI (HP:0002419)2.05428841
108Distal arthrogryposis (HP:0005684)2.04995640
109Hypergonadotropic hypogonadism (HP:0000815)2.04304964
110Renal duplication (HP:0000075)2.03019159
111Delayed cranial suture closure (HP:0000270)2.00993024
112Back pain (HP:0003418)2.00541524
113Patellar aplasia (HP:0006443)1.98816225
114Ulnar deviation of the wrist (HP:0003049)1.98524153
115Rough bone trabeculation (HP:0100670)1.98130567
116Syringomyelia (HP:0003396)1.97711628
117Spinal cord lesions (HP:0100561)1.97711628
118Disproportionate tall stature (HP:0001519)1.96843910
119Ulnar bowing (HP:0003031)1.96085487
120Amniotic constriction ring (HP:0009775)1.95521177
121Abnormality of placental membranes (HP:0011409)1.95521177
122Abnormality of the acetabulum (HP:0003170)1.95361471
123Sloping forehead (HP:0000340)1.94572690
124Calcaneovalgus deformity (HP:0001848)1.94285401
125Medial flaring of the eyebrow (HP:0010747)1.93139647
126Abnormality of the phalanges of the hallux (HP:0010057)1.91533168
1273-Methylglutaconic aciduria (HP:0003535)1.89984712
128Natal tooth (HP:0000695)1.89038709
129Microglossia (HP:0000171)1.88503908
130Dilatation of the ascending aorta (HP:0005111)1.87551713
131Abnormality of the tricuspid valve (HP:0001702)1.87027657
132Abnormal delivery (HP:0001787)1.86038530
133Follicular hyperkeratosis (HP:0007502)1.84549905
134Redundant skin (HP:0001582)1.84256766
135Distal upper limb amyotrophy (HP:0007149)1.84250493
136Upper limb amyotrophy (HP:0009129)1.84250493
137Postaxial foot polydactyly (HP:0001830)1.84062094
138Recurrent otitis media (HP:0000403)1.83947268
139Deformed tarsal bones (HP:0008119)1.83804526
140Abnormality of the duodenum (HP:0002246)1.83801724
141Overriding aorta (HP:0002623)1.83727697
142Centrally nucleated skeletal muscle fibers (HP:0003687)1.83635584
143Squamous cell carcinoma (HP:0002860)1.83621123
144Short thumb (HP:0009778)1.82907759
145Tongue fasciculations (HP:0001308)1.82856430
146Aplasia/Hypoplasia of the patella (HP:0006498)1.81704145
147Abnormality of the umbilical cord (HP:0010881)1.80521891
148Pulmonary fibrosis (HP:0002206)1.80028218
149Joint laxity (HP:0001388)1.79747431
150Poikiloderma (HP:0001029)1.78487138
151Spinal cord compression (HP:0002176)1.76984162
152Long palpebral fissure (HP:0000637)1.76364547
153Cleft eyelid (HP:0000625)1.76194719
154Hyperextensible skin (HP:0000974)1.74977061
155Oral leukoplakia (HP:0002745)1.73886117
156Abnormality of the calcaneus (HP:0008364)1.73614366
157Wrist flexion contracture (HP:0001239)1.73273230
158Overgrowth (HP:0001548)1.73261495
159Nephroblastoma (Wilms tumor) (HP:0002667)1.73010953
160Cardiovascular calcification (HP:0011915)1.72956766
161Pterygium (HP:0001059)1.72895597
162Median cleft lip (HP:0000161)1.72432129
163Congenital hepatic fibrosis (HP:0002612)1.71959674
164Pancreatic fibrosis (HP:0100732)1.71725869
165Congenital hip dislocation (HP:0001374)1.69954495
166Horseshoe kidney (HP:0000085)1.69450085
167Secondary amenorrhea (HP:0000869)1.69173265
168Testicular atrophy (HP:0000029)1.68470231
169Abnormality of pyrimidine metabolism (HP:0004353)1.68221004
170Ureteral duplication (HP:0000073)1.68154855
171Double outlet right ventricle (HP:0001719)1.67986405
172Congenital malformation of the right heart (HP:0011723)1.67986405
173Hypochromic anemia (HP:0001931)1.67699905
174Nonimmune hydrops fetalis (HP:0001790)1.67046035
175Abnormality of carpal bone ossification (HP:0006257)1.66621407
176Thin bony cortex (HP:0002753)1.66308636
177Abnormalities of placenta or umbilical cord (HP:0001194)1.65905008
178Increased nuchal translucency (HP:0010880)1.65779350
179Limb-girdle muscle atrophy (HP:0003797)1.65748661
180Biconcave vertebral bodies (HP:0004586)1.65711522
181Reduced antithrombin III activity (HP:0001976)1.64947853
182Hallux valgus (HP:0001822)1.64894799
183Neonatal short-limb short stature (HP:0008921)1.64233825
184Pancreatic cysts (HP:0001737)1.64133005
185Duplication of thumb phalanx (HP:0009942)1.63933925
186Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63186103
187Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63186103
188Knee flexion contracture (HP:0006380)1.63155328
189Oligodactyly (HP:0012165)1.63124490
190Deviation of the hallux (HP:0010051)1.62531083
191Rhabdomyosarcoma (HP:0002859)1.62009826
192Ventricular tachycardia (HP:0004756)1.60900756
193Facial hemangioma (HP:0000329)1.59323690
194Abnormal hemoglobin (HP:0011902)1.55528937
195Facial cleft (HP:0002006)1.55433060
196Oligodactyly (hands) (HP:0001180)1.55057011
197Recurrent bronchitis (HP:0002837)1.54527663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.31671987
2PDK33.16013475
3PDK43.16013475
4TTN3.04793093
5STK38L2.62960694
6NME22.61358450
7PDK22.54454897
8MAP3K62.53766017
9NEK12.45268116
10NEK22.38437907
11MUSK2.31448986
12TTK2.29382755
13ARAF2.28647962
14TRIB32.19650015
15CDC72.17335794
16MYLK2.15208345
17PLK42.14543257
18MKNK22.09986670
19PRPF4B2.07224436
20BUB12.04467446
21LIMK12.04292959
22PAK42.02116562
23WEE12.00291755
24LATS21.91464948
25TXK1.89302652
26BRAF1.86342003
27PDGFRA1.86028349
28SRPK11.83613829
29TLK11.76347478
30CHEK21.72683261
31PLK11.68752769
32ILK1.67633977
33MAP4K11.64531389
34PTK21.63907180
35PIK3CG1.63673981
36SMG11.58050720
37DMPK1.50598466
38MAP3K91.50080864
39IRAK31.46164169
40CDK81.45573971
41NLK1.42796318
42PAK21.42314692
43VRK11.41728406
44MET1.40656525
45TAOK31.37863348
46EIF2AK11.36413578
47CDK71.36159724
48STK241.35886228
49STK381.35652660
50NEK91.29616247
51EPHB21.28901201
52VRK21.24815644
53MAP3K141.23067797
54MAP3K111.22593783
55YES11.17314470
56DYRK31.17038605
57NUAK11.15098974
58PINK11.12080018
59SCYL21.10378123
60PIM11.10111032
61ICK1.09284228
62ZAK1.08954736
63TSSK61.08663876
64MAP3K101.06900838
65DDR21.02306162
66CDK41.01688772
67AURKB1.01637874
68STK30.99602193
69CASK0.98386932
70ABL20.98256062
71PRKD20.98175212
72TGFBR20.96691444
73MKNK10.96443156
74ATR0.96009379
75ERBB40.92052109
76IRAK40.91701446
77MELK0.90898185
78LATS10.90662296
79MTOR0.89580559
80NTRK10.88710451
81BMPR20.88476604
82AKT30.88113567
83BRSK10.86903903
84DAPK30.84954389
85SIK10.84289871
86EIF2AK20.83925713
87MAP3K130.83828670
88ERN10.83505066
89RAF10.81585820
90BRSK20.81239626
91CHEK10.78916854
92PRKD30.78601759
93JAK30.77159122
94AURKA0.76441944
95* ATM0.74561886
96MAP2K30.74381770
97CDK120.71030579
98FLT30.70716645
99RIPK40.68224307
100PIM20.68128557
101OBSCN0.68013255
102MST1R0.67411801
103IKBKB0.65733429
104TAOK20.65570954
105MAP2K70.65216312
106TIE10.64533253
107EEF2K0.63553460
108PAK10.63127818
109MAPKAPK30.58350750
110PLK30.57944975
111MAP3K120.57581947
112TESK10.57342335
113PKN20.56357051
114PBK0.55770328
115EIF2AK30.55671723
116CDK90.54620130
117PRKG20.54116434
118RPS6KB20.54010736
119NME10.53196764
120RPS6KA40.52577517
121MOS0.52447390
122IRAK10.51527710
123GRK60.50805588
124CSNK2A10.50623740
125BLK0.47949986
126CDK30.47453759
127CDK20.47436922
128AKT20.46646633
129TNIK0.46252823
130LRRK20.45193899
131EPHA20.44918468
132STK100.44269733
133ZAP700.44038061
134KSR20.43778528
135CDC42BPA0.42767700
136MAP3K80.42074778
137CCNB10.41759761
138CSNK2A20.41622241
139STK40.41419634
140ROCK20.41205888
141MAP3K30.41121909
142TRPM70.40997141
143IRAK20.40011376
144GRK70.38937027
145MAPK130.38306734
146TESK20.38099912
147GRK10.37866717
148MAP3K50.36896875
149CAMK2G0.36226246
150MAPK110.36017011
151DYRK20.33706472
152CSK0.33505254
153TAF10.32063507

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.74348706
2DNA replication_Homo sapiens_hsa030303.68861641
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42343273
4Mismatch repair_Homo sapiens_hsa034303.35907730
5Ribosome_Homo sapiens_hsa030103.32635350
6Vitamin B6 metabolism_Homo sapiens_hsa007503.12172150
7Basal transcription factors_Homo sapiens_hsa030223.12094865
8RNA polymerase_Homo sapiens_hsa030203.08372281
9Homologous recombination_Homo sapiens_hsa034403.06103469
10Base excision repair_Homo sapiens_hsa034102.99316718
11Nucleotide excision repair_Homo sapiens_hsa034202.65580730
12RNA transport_Homo sapiens_hsa030132.57960602
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.48505884
14RNA degradation_Homo sapiens_hsa030182.46081480
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.45411284
16Pyrimidine metabolism_Homo sapiens_hsa002402.42216750
17Spliceosome_Homo sapiens_hsa030402.28154501
18Cell cycle_Homo sapiens_hsa041102.27300179
19ECM-receptor interaction_Homo sapiens_hsa045122.17722382
20One carbon pool by folate_Homo sapiens_hsa006702.02644103
21Non-homologous end-joining_Homo sapiens_hsa034501.89894037
22Linoleic acid metabolism_Homo sapiens_hsa005911.72200481
23mRNA surveillance pathway_Homo sapiens_hsa030151.72088009
24Focal adhesion_Homo sapiens_hsa045101.68925509
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68332266
26Proteasome_Homo sapiens_hsa030501.66834709
27Purine metabolism_Homo sapiens_hsa002301.56965100
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55499162
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52855158
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47707758
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47290202
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46873024
33Biosynthesis of amino acids_Homo sapiens_hsa012301.42903884
34Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42502614
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39327896
36Thyroid cancer_Homo sapiens_hsa052161.35985853
37Bladder cancer_Homo sapiens_hsa052191.35031192
38Proteoglycans in cancer_Homo sapiens_hsa052051.33460281
39Primary immunodeficiency_Homo sapiens_hsa053401.31882552
40Dilated cardiomyopathy_Homo sapiens_hsa054141.31305605
41p53 signaling pathway_Homo sapiens_hsa041151.29606315
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.26599351
43Galactose metabolism_Homo sapiens_hsa000521.21681955
44Adherens junction_Homo sapiens_hsa045201.18182808
45Carbon metabolism_Homo sapiens_hsa012001.17407906
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16501544
47Arachidonic acid metabolism_Homo sapiens_hsa005901.12354797
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09875371
49Sulfur relay system_Homo sapiens_hsa041221.05815324
50Huntingtons disease_Homo sapiens_hsa050161.04589110
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04131398
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00673493
53Hippo signaling pathway_Homo sapiens_hsa043901.00278390
54Amoebiasis_Homo sapiens_hsa051460.99626239
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97446735
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.96749861
57Herpes simplex infection_Homo sapiens_hsa051680.94749545
58Chronic myeloid leukemia_Homo sapiens_hsa052200.94615696
59N-Glycan biosynthesis_Homo sapiens_hsa005100.94068104
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91128910
61Parkinsons disease_Homo sapiens_hsa050120.90830496
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89220344
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.88831166
64MicroRNAs in cancer_Homo sapiens_hsa052060.88200863
65Melanoma_Homo sapiens_hsa052180.85572087
66Ether lipid metabolism_Homo sapiens_hsa005650.85336636
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.84235873
68Oocyte meiosis_Homo sapiens_hsa041140.82529125
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82261070
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81513440
71Pancreatic cancer_Homo sapiens_hsa052120.81105040
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77862751
73Cardiac muscle contraction_Homo sapiens_hsa042600.76786482
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75953955
75Sulfur metabolism_Homo sapiens_hsa009200.73583331
76Tight junction_Homo sapiens_hsa045300.73533734
77Prion diseases_Homo sapiens_hsa050200.71464264
78Epstein-Barr virus infection_Homo sapiens_hsa051690.71383878
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70743179
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.66483491
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65541247
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65109131
83Measles_Homo sapiens_hsa051620.64850992
84Pathways in cancer_Homo sapiens_hsa052000.64251736
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64075217
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63595652
87Systemic lupus erythematosus_Homo sapiens_hsa053220.63377149
88Basal cell carcinoma_Homo sapiens_hsa052170.61484341
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.59388341
90Alzheimers disease_Homo sapiens_hsa050100.58457848
91Renal cell carcinoma_Homo sapiens_hsa052110.58330224
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.57213911
93Fatty acid biosynthesis_Homo sapiens_hsa000610.57112852
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.56903401
95Other glycan degradation_Homo sapiens_hsa005110.56900847
96Vitamin digestion and absorption_Homo sapiens_hsa049770.55443170
97Protein digestion and absorption_Homo sapiens_hsa049740.54990375
98Protein export_Homo sapiens_hsa030600.54969168
99Colorectal cancer_Homo sapiens_hsa052100.53506084
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53179918
101Glutathione metabolism_Homo sapiens_hsa004800.52511221
102Selenocompound metabolism_Homo sapiens_hsa004500.51735859
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50615486
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48932016
105Autoimmune thyroid disease_Homo sapiens_hsa053200.48510115
106Hedgehog signaling pathway_Homo sapiens_hsa043400.48375949
107Metabolic pathways_Homo sapiens_hsa011000.48369511
108Arginine biosynthesis_Homo sapiens_hsa002200.47544402
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47256619
110Endometrial cancer_Homo sapiens_hsa052130.46706390
111Prostate cancer_Homo sapiens_hsa052150.46667245
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46534530
113Retinol metabolism_Homo sapiens_hsa008300.46332343
114Vibrio cholerae infection_Homo sapiens_hsa051100.45918523
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45688931
116Wnt signaling pathway_Homo sapiens_hsa043100.45657279
117Allograft rejection_Homo sapiens_hsa053300.45452287
118Notch signaling pathway_Homo sapiens_hsa043300.44526386
119Folate biosynthesis_Homo sapiens_hsa007900.43304203
120Pentose phosphate pathway_Homo sapiens_hsa000300.43259890
121Antigen processing and presentation_Homo sapiens_hsa046120.43228877
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41717043
123Apoptosis_Homo sapiens_hsa042100.41472625
124Graft-versus-host disease_Homo sapiens_hsa053320.40901401
125Arginine and proline metabolism_Homo sapiens_hsa003300.40308846
126HTLV-I infection_Homo sapiens_hsa051660.40110223
127Acute myeloid leukemia_Homo sapiens_hsa052210.39962213
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39754302
129Circadian rhythm_Homo sapiens_hsa047100.39710064
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39540499
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.39116222
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38695896
133TGF-beta signaling pathway_Homo sapiens_hsa043500.36147177
134Sphingolipid metabolism_Homo sapiens_hsa006000.36027100
135Inositol phosphate metabolism_Homo sapiens_hsa005620.36006610
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35212523
137Hematopoietic cell lineage_Homo sapiens_hsa046400.35102116
138Fructose and mannose metabolism_Homo sapiens_hsa000510.34427811
139Regulation of autophagy_Homo sapiens_hsa041400.31604948
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31488237
141Viral carcinogenesis_Homo sapiens_hsa052030.31207492
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30436811
143Nicotine addiction_Homo sapiens_hsa050330.28844879
144Shigellosis_Homo sapiens_hsa051310.28458405
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.28009011
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27764742
147T cell receptor signaling pathway_Homo sapiens_hsa046600.27387877
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26759429
149Oxidative phosphorylation_Homo sapiens_hsa001900.24779610
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24413772
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22483529
152B cell receptor signaling pathway_Homo sapiens_hsa046620.20700003
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20221707
154Small cell lung cancer_Homo sapiens_hsa052220.19016931
155Hepatitis B_Homo sapiens_hsa051610.18352778
156Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16776196
157Pyruvate metabolism_Homo sapiens_hsa006200.16606849

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