AVIL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)8.10550789
2detection of temperature stimulus (GO:0016048)7.55238978
3detection of temperature stimulus involved in sensory perception (GO:0050961)7.53831037
4detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.53831037
5negative regulation of dendrite morphogenesis (GO:0050774)6.85546781
6peripheral nervous system neuron development (GO:0048935)6.61737761
7negative regulation of calcium ion transport into cytosol (GO:0010523)6.41461442
8neuronal action potential (GO:0019228)6.10239893
9cell migration in hindbrain (GO:0021535)5.86472676
10response to pain (GO:0048265)5.09956053
11regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.06905833
12behavioral response to pain (GO:0048266)4.92417658
13positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.84093025
14proline transport (GO:0015824)4.70921904
15regulation of female receptivity (GO:0045924)4.70559819
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.67875276
17response to water (GO:0009415)4.66580196
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.63363691
19negative regulation of microtubule polymerization (GO:0031115)4.57499659
20membrane depolarization during action potential (GO:0086010)4.52904391
21negative regulation of Rho protein signal transduction (GO:0035024)4.38150498
22negative regulation of dendrite development (GO:2000171)4.28911757
23neuronal action potential propagation (GO:0019227)4.16372320
24cell communication involved in cardiac conduction (GO:0086065)4.00633433
25intermediate filament organization (GO:0045109)3.88137633
26detection of mechanical stimulus involved in sensory perception (GO:0050974)3.87614978
27protein K11-linked deubiquitination (GO:0035871)3.87597523
28enteric nervous system development (GO:0048484)3.85074816
29urinary tract smooth muscle contraction (GO:0014848)3.81142761
30membrane budding (GO:0006900)3.80428375
31positive regulation of potassium ion transmembrane transport (GO:1901381)3.77187356
32axon cargo transport (GO:0008088)3.76364239
33female mating behavior (GO:0060180)3.72527597
34negative regulation of cation channel activity (GO:2001258)3.72083420
35cellular response to nicotine (GO:0071316)3.67500943
36establishment of mitochondrion localization (GO:0051654)3.63228864
37intermediate filament-based process (GO:0045103)3.57236004
38intermediate filament cytoskeleton organization (GO:0045104)3.56365994
39negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.55927777
40action potential (GO:0001508)3.55230859
41negative regulation of homotypic cell-cell adhesion (GO:0034111)3.54247934
42adenosine metabolic process (GO:0046085)3.53044586
43calcium-mediated signaling using intracellular calcium source (GO:0035584)3.50258676
44potassium ion export (GO:0071435)3.48509467
45plasma membrane repair (GO:0001778)3.43864785
46retinal ganglion cell axon guidance (GO:0031290)3.42869219
47epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35428745
48cellular response to ATP (GO:0071318)3.35168435
49regulation of memory T cell differentiation (GO:0043380)3.34565542
50neural tube formation (GO:0001841)3.32985451
51membrane repolarization (GO:0086009)3.28857999
52response to acidic pH (GO:0010447)3.27066483
53regulation of platelet aggregation (GO:0090330)3.26859043
54establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.26811225
55mitochondrion transport along microtubule (GO:0047497)3.26811225
56neuromuscular synaptic transmission (GO:0007274)3.26118580
57response to ATP (GO:0033198)3.22538004
58regulation of skeletal muscle contraction (GO:0014819)3.22321287
59negative regulation of complement activation (GO:0045916)3.21840459
60regulation of amyloid precursor protein catabolic process (GO:1902991)3.21614122
61positive regulation of cardiac muscle hypertrophy (GO:0010613)3.20439666
62positive regulation of muscle hypertrophy (GO:0014742)3.20439666
63neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.19240715
64axon development (GO:0061564)3.16073331
65sympathetic nervous system development (GO:0048485)3.15749013
66glutamate secretion (GO:0014047)3.15006397
67positive regulation of potassium ion transport (GO:0043268)3.13294458
68somite development (GO:0061053)3.13191365
69sodium ion transmembrane transport (GO:0035725)3.12991351
70regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.12903047
71protein maturation by protein folding (GO:0022417)3.07026721
72axoneme assembly (GO:0035082)3.05182892
73detection of light stimulus involved in sensory perception (GO:0050962)3.04380473
74detection of light stimulus involved in visual perception (GO:0050908)3.04380473
75neuron fate specification (GO:0048665)3.04258869
76negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.03191132
77synaptic vesicle maturation (GO:0016188)3.02913155
78regulation of cell maturation (GO:1903429)3.02839725
79innervation (GO:0060384)3.02559004
80positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02446299
81phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.01712195
82sodium ion export (GO:0071436)2.99838442
83calcium ion-dependent exocytosis (GO:0017156)2.97042758
84regulation of translational termination (GO:0006449)2.95601827
85behavioral response to nicotine (GO:0035095)2.94442372
86regulation of sodium ion transmembrane transporter activity (GO:2000649)2.92078265
87sulfation (GO:0051923)2.91445896
88regulation of sequestering of triglyceride (GO:0010889)2.90773813
89organelle transport along microtubule (GO:0072384)2.89427320
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89187978
91acrosome reaction (GO:0007340)2.88518114
92regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.87611277
93regulation of cell communication by electrical coupling (GO:0010649)2.87393603
94negative regulation of mast cell activation (GO:0033004)2.86874595
95fucose catabolic process (GO:0019317)2.86392665
96L-fucose metabolic process (GO:0042354)2.86392665
97L-fucose catabolic process (GO:0042355)2.86392665
98phenol-containing compound catabolic process (GO:0019336)2.86185076
99alanine transport (GO:0032328)2.85015294
100negative regulation of ion transmembrane transporter activity (GO:0032413)2.84629821
101vesicle transport along microtubule (GO:0047496)2.84575713
102regulation of synaptic vesicle exocytosis (GO:2000300)2.84241789
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.84236460
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83261557
105regulation of germinal center formation (GO:0002634)2.82716774
106indolalkylamine metabolic process (GO:0006586)2.80677150
107histone H3-K4 trimethylation (GO:0080182)2.80559984
108multicellular organismal response to stress (GO:0033555)2.79605034
109regulation of potassium ion transmembrane transporter activity (GO:1901016)2.79097610
110axon regeneration (GO:0031103)2.79093859
111branching involved in labyrinthine layer morphogenesis (GO:0060670)2.78098301
112positive regulation of oligodendrocyte differentiation (GO:0048714)2.77124161
113regulation of histone phosphorylation (GO:0033127)2.75841686
114sensory perception of taste (GO:0050909)2.74408850
115positive regulation of fatty acid oxidation (GO:0046321)2.74389938
116regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74181918
117synaptic vesicle exocytosis (GO:0016079)2.72964703
118adaptation of signaling pathway (GO:0023058)2.72944650
119response to pheromone (GO:0019236)2.72893193
120cilium or flagellum-dependent cell motility (GO:0001539)2.70713427
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69945410
122protein polyglutamylation (GO:0018095)2.69285491
123phosphatidylinositol acyl-chain remodeling (GO:0036149)2.68959927
124negative regulation of sodium ion transport (GO:0010766)2.68800996
125indole-containing compound catabolic process (GO:0042436)2.67697938
126indolalkylamine catabolic process (GO:0046218)2.67697938
127tryptophan catabolic process (GO:0006569)2.67697938
128thrombin receptor signaling pathway (GO:0070493)2.67619263
129negative regulation of cAMP-mediated signaling (GO:0043951)2.66801360
130regulation of sensory perception of pain (GO:0051930)2.66150853
131regulation of sensory perception (GO:0051931)2.66150853
132negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.65598298
133regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.64391412
134negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64147738
135negative regulation of cell killing (GO:0031342)2.64147738
136germinal center formation (GO:0002467)2.60396143
137alkaloid metabolic process (GO:0009820)2.57807607
138synaptic transmission, cholinergic (GO:0007271)2.56937234
139kynurenine metabolic process (GO:0070189)2.56812774
140cell wall macromolecule catabolic process (GO:0016998)2.55886776
141DNA deamination (GO:0045006)2.54003827
142cAMP catabolic process (GO:0006198)2.53347438
143negative regulation of T-helper cell differentiation (GO:0045623)2.51847581
144negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51847581
145transmission of nerve impulse (GO:0019226)2.51682488
146epithelial cilium movement (GO:0003351)2.50231845
147negative regulation of systemic arterial blood pressure (GO:0003085)2.49525037
148tachykinin receptor signaling pathway (GO:0007217)2.46792265
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.46529493
150pyrimidine nucleobase catabolic process (GO:0006208)2.44793100
151establishment of protein localization to Golgi (GO:0072600)2.44314678
152head development (GO:0060322)2.44200110
153response to lipoprotein particle (GO:0055094)2.43049272
154positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.42374585
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42163340
156histone H3-K9 methylation (GO:0051567)2.41806159
157histone H3-K9 modification (GO:0061647)2.41147737
158dentate gyrus development (GO:0021542)2.40509443
159monoubiquitinated protein deubiquitination (GO:0035520)2.39432760
160oxygen transport (GO:0015671)2.37251319
161photoreceptor cell maintenance (GO:0045494)2.36454190
162embryonic epithelial tube formation (GO:0001838)2.35816413
163preassembly of GPI anchor in ER membrane (GO:0016254)2.35471251
164activated T cell proliferation (GO:0050798)2.34962769
1653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.32763550
166purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.32763550
167retinal cone cell development (GO:0046549)2.29610838
168negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29389552
169snRNA transcription (GO:0009301)2.28718579
170thyroid hormone metabolic process (GO:0042403)2.28651678
171neutrophil mediated immunity (GO:0002446)2.28580966
172cyclic nucleotide catabolic process (GO:0009214)2.27860259
173drug catabolic process (GO:0042737)2.27821734
174negative regulation of response to food (GO:0032096)2.27719941
175negative regulation of appetite (GO:0032099)2.27719941
176protein K48-linked deubiquitination (GO:0071108)2.27690768
177negative regulation by host of viral transcription (GO:0043922)2.27053268
178long term synaptic depression (GO:0060292)2.26927593
179regulation of B cell receptor signaling pathway (GO:0050855)2.26046698
180regulation of action potential (GO:0098900)2.23350612
181cilium movement (GO:0003341)2.22760017
182positive regulation of cAMP-mediated signaling (GO:0043950)2.22537853
183termination of G-protein coupled receptor signaling pathway (GO:0038032)2.21542282
184myeloid leukocyte mediated immunity (GO:0002444)2.20757250
185phosphatidylethanolamine biosynthetic process (GO:0006646)2.19983882
186phosphatidylethanolamine metabolic process (GO:0046337)2.19920233
187negative regulation of cell cycle arrest (GO:0071157)2.19756893
188regulation of interferon-beta biosynthetic process (GO:0045357)2.19250733
189antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.19234203
190striated muscle atrophy (GO:0014891)2.19049539
191nonmotile primary cilium assembly (GO:0035058)2.18380809
192protein K63-linked deubiquitination (GO:0070536)2.15627431
193oxidative demethylation (GO:0070989)2.15179062
194positive regulation of defense response to virus by host (GO:0002230)2.14656673

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR2_21235772_ChIP-Seq_MCF-7_Human2.98048777
2ZNF263_19887448_ChIP-Seq_K562_Human2.94113154
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61171902
4NR3C1_23031785_ChIP-Seq_PC12_Mouse2.59093707
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.57763747
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44258790
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40114748
8TAF15_26573619_Chip-Seq_HEK293_Human2.25047325
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21406411
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20833503
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19974481
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17082070
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16289472
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12959648
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12959648
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99877663
17VDR_22108803_ChIP-Seq_LS180_Human1.99529020
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92515171
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89727927
20REST_21632747_ChIP-Seq_MESCs_Mouse1.87255680
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87255281
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81629344
23IGF1R_20145208_ChIP-Seq_DFB_Human1.79368481
24ER_23166858_ChIP-Seq_MCF-7_Human1.78936898
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77631975
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75826161
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.74672901
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74672573
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71427729
30DROSHA_22980978_ChIP-Seq_HELA_Human1.70738787
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.69405776
32ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67881743
33EGR1_19032775_ChIP-ChIP_M12_Human1.66253328
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.63774163
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61811487
36CTCF_27219007_Chip-Seq_Bcells_Human1.59651960
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58920362
38AHR_22903824_ChIP-Seq_MCF-7_Human1.58258672
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55049658
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.54362704
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54158908
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52434845
43EZH2_22144423_ChIP-Seq_EOC_Human1.51983220
44SMAD4_21799915_ChIP-Seq_A2780_Human1.51225891
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48852577
46GBX2_23144817_ChIP-Seq_PC3_Human1.48322706
47KDM2B_26808549_Chip-Seq_K562_Human1.46563673
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.46200237
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45940607
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45478017
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.45368383
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44604590
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44604590
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44031782
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.43992223
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.43781420
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.41295145
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40483176
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39895348
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38378076
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37498741
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.37363605
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35130750
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34998897
65BCAT_22108803_ChIP-Seq_LS180_Human1.34163659
66IRF1_19129219_ChIP-ChIP_H3396_Human1.31251226
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30894113
68FUS_26573619_Chip-Seq_HEK293_Human1.29326299
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28215855
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27855628
71SOX2_20726797_ChIP-Seq_SW620_Human1.27601299
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25826977
73TCF4_23295773_ChIP-Seq_U87_Human1.25549048
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.24752297
75TP53_16413492_ChIP-PET_HCT116_Human1.22252099
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.20794158
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20166585
78* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19704582
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19536715
80AR_21572438_ChIP-Seq_LNCaP_Human1.19101598
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19021316
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.18921676
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18883343
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17336430
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.17314114
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14080887
87EP300_21415370_ChIP-Seq_HL-1_Mouse1.13153845
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.12923874
89* TP53_22573176_ChIP-Seq_HFKS_Human1.11965792
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11956555
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11289045
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10689521
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10105843
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.10104194
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.09811152
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09680390
97P300_19829295_ChIP-Seq_ESCs_Human1.09485574
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09283903
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.08755705
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.08702047
101EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08387606
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.08293487
103KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08280806
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07816307
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06912551
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06839313
107RUNX2_22187159_ChIP-Seq_PCA_Human1.06440636
108AR_25329375_ChIP-Seq_VCAP_Human1.06157858
109GATA3_21878914_ChIP-Seq_MCF-7_Human1.05040500
110SMAD4_21741376_ChIP-Seq_HESCs_Human1.04141429
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03775423
112EWS_26573619_Chip-Seq_HEK293_Human1.03310464
113CJUN_26792858_Chip-Seq_BT549_Human1.02619849
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02572317
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.02362925
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01951576
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01527868
118CBP_20019798_ChIP-Seq_JUKART_Human1.01527868
119SMAD3_21741376_ChIP-Seq_ESCs_Human1.01246202
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99698206
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99661230
122NFE2_27457419_Chip-Seq_LIVER_Mouse0.98647967
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.97873844
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97379864
125NCOR_22424771_ChIP-Seq_293T_Human0.96733776
126SMRT_27268052_Chip-Seq_Bcells_Human0.96730210
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96706277
128OCT1_27270436_Chip-Seq_PROSTATE_Human0.96459355
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.95716518
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.95697829
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.95520057
132NANOG_19829295_ChIP-Seq_ESCs_Human0.95136455
133SOX2_19829295_ChIP-Seq_ESCs_Human0.95136455
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95029550
135TBL1_22424771_ChIP-Seq_293T_Human0.93810532
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93614499
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93430946
138KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93319587
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92397427
140* CDX2_22108803_ChIP-Seq_LS180_Human0.91647525
141RUNX_20019798_ChIP-Seq_JUKART_Human0.90667881
142PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90307712
143* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90231910
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90192023
145OCT4_20526341_ChIP-Seq_ESCs_Human0.90078268
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89940151
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89426722
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89397003
149STAT3_23295773_ChIP-Seq_U87_Human0.89038918
150CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88894187
151KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88654317
152PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88304898
153ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88031405
154JUN_21703547_ChIP-Seq_K562_Human0.87862869
155IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87671001
156MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87276195
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86059807
158TCF4_22108803_ChIP-Seq_LS180_Human0.85671425
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85643430
160STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85406247
161CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85364458
162NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84781445
163ZNF274_21170338_ChIP-Seq_K562_Hela0.84333154
164WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84105138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception7.75712649
2MP0001968_abnormal_touch/_nociception6.67470174
3MP0001986_abnormal_taste_sensitivity6.13471320
4MP0002736_abnormal_nociception_after5.93891146
5MP0004270_analgesia4.79091664
6MP0002733_abnormal_thermal_nociception4.59805987
7MP0002734_abnormal_mechanical_nocicepti4.17115245
8MP0006276_abnormal_autonomic_nervous4.10258604
9MP0003787_abnormal_imprinting4.01350846
10MP0001970_abnormal_pain_threshold3.79876347
11MP0005645_abnormal_hypothalamus_physiol3.65087052
12MP0003646_muscle_fatigue3.53798880
13MP0003724_increased_susceptibility_to3.25614308
14MP0003195_calcinosis3.04137252
15MP0002138_abnormal_hepatobiliary_system2.49337740
16MP0002751_abnormal_autonomic_nervous2.45859718
17MP0002653_abnormal_ependyma_morphology2.42583336
18MP0001485_abnormal_pinna_reflex2.35510448
19MP0004130_abnormal_muscle_cell2.33284034
20* MP0004858_abnormal_nervous_system2.32119441
21MP0000569_abnormal_digit_pigmentation2.24921327
22MP0004859_abnormal_synaptic_plasticity2.10345449
23MP0000631_abnormal_neuroendocrine_gland2.02547577
24MP0008877_abnormal_DNA_methylation1.99257167
25MP0005670_abnormal_white_adipose1.96667477
26MP0005551_abnormal_eye_electrophysiolog1.93642588
27MP0002184_abnormal_innervation1.93421205
28MP0002272_abnormal_nervous_system1.91903787
29MP0004885_abnormal_endolymph1.85400546
30MP0004043_abnormal_pH_regulation1.83962488
31MP0002067_abnormal_sensory_capabilities1.82725183
32MP0003329_amyloid_beta_deposits1.77673905
33MP0002822_catalepsy1.71590338
34MP0000372_irregular_coat_pigmentation1.66815039
35MP0005083_abnormal_biliary_tract1.65667112
36MP0002102_abnormal_ear_morphology1.65548340
37MP0005646_abnormal_pituitary_gland1.64068448
38MP0003656_abnormal_erythrocyte_physiolo1.63768851
39MP0001348_abnormal_lacrimal_gland1.61684168
40MP0002876_abnormal_thyroid_physiology1.60111209
41MP0004381_abnormal_hair_follicle1.56969661
42MP0005174_abnormal_tail_pigmentation1.55607718
43MP0008260_abnormal_autophagy1.51213290
44MP0001270_distended_abdomen1.49664563
45MP0003878_abnormal_ear_physiology1.42081139
46MP0005377_hearing/vestibular/ear_phenot1.42081139
47MP0003635_abnormal_synaptic_transmissio1.38426120
48* MP0004811_abnormal_neuron_physiology1.35189130
49MP0000538_abnormal_urinary_bladder1.35002879
50MP0003183_abnormal_peptide_metabolism1.34539171
51MP0000955_abnormal_spinal_cord1.32151309
52MP0005310_abnormal_salivary_gland1.31262747
53MP0008004_abnormal_stomach_pH1.28276842
54MP0002277_abnormal_respiratory_mucosa1.28250410
55MP0001440_abnormal_grooming_behavior1.25630232
56MP0003121_genomic_imprinting1.20843282
57MP0000230_abnormal_systemic_arterial1.18897483
58MP0009745_abnormal_behavioral_response1.17046788
59MP0005367_renal/urinary_system_phenotyp1.15963978
60MP0000516_abnormal_urinary_system1.15963978
61MP0000749_muscle_degeneration1.14225729
62MP0010386_abnormal_urinary_bladder1.12531779
63MP0002837_dystrophic_cardiac_calcinosis1.11484083
64MP0002064_seizures1.10301669
65MP0004147_increased_porphyrin_level1.09581424
66MP0009046_muscle_twitch1.06750047
67MP0001664_abnormal_digestion1.06541719
68MP0001800_abnormal_humoral_immune1.05346379
69MP0002928_abnormal_bile_duct1.04120693
70MP0005167_abnormal_blood-brain_barrier1.04095033
71MP0002063_abnormal_learning/memory/cond1.02189771
72MP0000604_amyloidosis1.01550577
73MP0005253_abnormal_eye_physiology1.01043863
74MP0009764_decreased_sensitivity_to1.00260199
75MP0000751_myopathy0.98448094
76MP0000026_abnormal_inner_ear0.98298273
77MP0002572_abnormal_emotion/affect_behav0.97621874
78MP0008875_abnormal_xenobiotic_pharmacok0.94618213
79MP0005075_abnormal_melanosome_morpholog0.93478180
80MP0008872_abnormal_physiological_respon0.93351895
81MP0001486_abnormal_startle_reflex0.91390727
82MP0003633_abnormal_nervous_system0.91351489
83MP0000015_abnormal_ear_pigmentation0.90442092
84MP0001905_abnormal_dopamine_level0.88507771
85MP0009765_abnormal_xenobiotic_induced0.87480569
86MP0002332_abnormal_exercise_endurance0.87203995
87MP0001299_abnormal_eye_distance/0.87143918
88* MP0002882_abnormal_neuron_morphology0.86740316
89MP0003880_abnormal_central_pattern0.86608210
90MP0000747_muscle_weakness0.85157862
91MP0002909_abnormal_adrenal_gland0.84704612
92MP0000013_abnormal_adipose_tissue0.84546421
93MP0002163_abnormal_gland_morphology0.84245967
94MP0008569_lethality_at_weaning0.83953504
95MP0001963_abnormal_hearing_physiology0.83834219
96MP0002148_abnormal_hypersensitivity_rea0.82658399
97MP0004924_abnormal_behavior0.81279370
98MP0005386_behavior/neurological_phenoty0.81279370
99MP0008874_decreased_physiological_sensi0.81026234
100MP0003868_abnormal_feces_composition0.81022175
101MP0005620_abnormal_muscle_contractility0.79672112
102MP0003045_fibrosis0.79178733
103MP0000427_abnormal_hair_cycle0.78717884
104MP0000685_abnormal_immune_system0.78414970
105MP0001765_abnormal_ion_homeostasis0.78242513
106MP0004883_abnormal_blood_vessel0.78007954
107MP0010771_integument_phenotype0.77747351
108MP0003011_delayed_dark_adaptation0.77435229
109MP0000049_abnormal_middle_ear0.74767580
110MP0005387_immune_system_phenotype0.74630483
111MP0001790_abnormal_immune_system0.74630483
112MP0002132_abnormal_respiratory_system0.74154519
113MP0001984_abnormal_olfaction0.73722700
114MP0000534_abnormal_ureter_morphology0.72980284
115MP0003866_abnormal_defecation0.72559749
116MP0010234_abnormal_vibrissa_follicle0.71915902
117MP0009785_altered_susceptibility_to0.71570451
118MP0002723_abnormal_immune_serum0.70981115
119MP0003631_nervous_system_phenotype0.70187501
120MP0000778_abnormal_nervous_system0.69961357
121MP0005195_abnormal_posterior_eye0.69623568
122MP0005423_abnormal_somatic_nervous0.69490576
123MP0001835_abnormal_antigen_presentation0.69347506
124MP0003634_abnormal_glial_cell0.69196008
125MP0005220_abnormal_exocrine_pancreas0.68668985
126MP0001501_abnormal_sleep_pattern0.67183653
127MP0002638_abnormal_pupillary_reflex0.66684892
128MP0008775_abnormal_heart_ventricle0.66433105
129* MP0002229_neurodegeneration0.66238518
130* MP0002066_abnormal_motor_capabilities/c0.65320291
131MP0002108_abnormal_muscle_morphology0.64799650
132MP0003136_yellow_coat_color0.63543078
133MP0002452_abnormal_antigen_presenting0.63534617
134MP0002168_other_aberrant_phenotype0.63527538
135MP0002419_abnormal_innate_immunity0.62423233
136MP0004742_abnormal_vestibular_system0.61341214
137MP0004142_abnormal_muscle_tone0.58634172
138* MP0002752_abnormal_somatic_nervous0.57652959
139MP0002160_abnormal_reproductive_system0.55190810
140MP0005165_increased_susceptibility_to0.53730666
141MP0004085_abnormal_heartbeat0.53252714
142MP0003806_abnormal_nucleotide_metabolis0.53112917
143MP0003879_abnormal_hair_cell0.53096767
144MP0001873_stomach_inflammation0.52620695
145MP0004484_altered_response_of0.51559702
146MP0004036_abnormal_muscle_relaxation0.51361452
147MP0001542_abnormal_bone_strength0.48938115
148MP0002557_abnormal_social/conspecific_i0.48862964
149MP0001756_abnormal_urination0.48651942
150MP0002972_abnormal_cardiac_muscle0.47445662
151MP0003300_gastrointestinal_ulcer0.44893659
152MP0000920_abnormal_myelination0.44086196
153MP0009379_abnormal_foot_pigmentation0.43327441
154MP0005535_abnormal_body_temperature0.43195648
155MP0001663_abnormal_digestive_system0.41648121
156MP0004145_abnormal_muscle_electrophysio0.40951530
157MP0009780_abnormal_chondrocyte_physiolo0.39226796
158MP0003566_abnormal_cell_adhesion0.37097353
159MP0001849_ear_inflammation0.34797618
160MP0000759_abnormal_skeletal_muscle0.34597750
161MP0005623_abnormal_meninges_morphology0.33406807
162MP0002269_muscular_atrophy0.32822094
163MP0001943_abnormal_respiration0.32719513

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.35892631
2Myokymia (HP:0002411)6.03485219
3Segmental peripheral demyelination/remyelination (HP:0003481)5.91127364
4Termporal pattern (HP:0011008)5.81129973
5Insidious onset (HP:0003587)5.81129973
6Hypothermia (HP:0002045)5.76033515
7Action tremor (HP:0002345)5.22799548
8Pheochromocytoma (HP:0002666)5.01855112
9Impaired pain sensation (HP:0007328)4.84264913
10Abnormality of pain sensation (HP:0010832)4.84264913
11Dysautonomia (HP:0002459)4.81766198
12Neuroendocrine neoplasm (HP:0100634)4.64580391
13Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.28946956
14Steppage gait (HP:0003376)4.26067545
15Foot dorsiflexor weakness (HP:0009027)4.25893735
16Congenital stationary night blindness (HP:0007642)4.19018872
17Hammertoe (HP:0001765)4.07939599
18Abnormal autonomic nervous system physiology (HP:0012332)3.89155967
19Abnormality of the foot musculature (HP:0001436)3.77246098
20Pancreatic cysts (HP:0001737)3.75952062
21Distal arthrogryposis (HP:0005684)3.64429804
22True hermaphroditism (HP:0010459)3.62453331
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.62426084
24Short 1st metacarpal (HP:0010034)3.57861503
25Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.57861503
26Myotonia (HP:0002486)3.57517686
27Pancreatic fibrosis (HP:0100732)3.52237703
28Abnormality of midbrain morphology (HP:0002418)3.47336000
29Molar tooth sign on MRI (HP:0002419)3.47336000
30Onion bulb formation (HP:0003383)3.44223395
31Abnormality of the vocal cords (HP:0008777)3.37339387
32Hyporeflexia of lower limbs (HP:0002600)3.32683535
33Chronic hepatic failure (HP:0100626)3.32518151
34Hypercortisolism (HP:0001578)3.31158801
35Absent/shortened dynein arms (HP:0200106)3.27290290
36Dynein arm defect of respiratory motile cilia (HP:0012255)3.27290290
37Autoamputation (HP:0001218)3.27262060
38Nephronophthisis (HP:0000090)3.19685040
39Failure to thrive in infancy (HP:0001531)3.16678490
40Atonic seizures (HP:0010819)3.13077550
41Decreased motor nerve conduction velocity (HP:0003431)3.11081443
42Distal sensory impairment (HP:0002936)3.10454146
43Abnormality of the 1st metacarpal (HP:0010009)3.09496078
44Absent rod-and cone-mediated responses on ERG (HP:0007688)3.08643905
45Abnormal rod and cone electroretinograms (HP:0008323)3.04911451
46Neoplasm of the peripheral nervous system (HP:0100007)3.04575024
47Keratoconjunctivitis (HP:0001096)3.03334437
48Supranuclear gaze palsy (HP:0000605)2.94991095
49Attenuation of retinal blood vessels (HP:0007843)2.93858427
50Thoracolumbar scoliosis (HP:0002944)2.92039137
51Bradycardia (HP:0001662)2.91230396
52Focal seizures (HP:0007359)2.89183985
53Keratoconjunctivitis sicca (HP:0001097)2.88446052
54Thyroid carcinoma (HP:0002890)2.86152916
55Ankle clonus (HP:0011448)2.83422463
56Abnormality of the renal medulla (HP:0100957)2.80602011
57Postural tremor (HP:0002174)2.78415380
58Orthostatic hypotension (HP:0001278)2.78345776
59Febrile seizures (HP:0002373)2.70710928
60Congenital sensorineural hearing impairment (HP:0008527)2.67595588
61Abnormality of the renal cortex (HP:0011035)2.65700662
62Hypoventilation (HP:0002791)2.65180232
63Submucous cleft hard palate (HP:0000176)2.64581227
64Progressive cerebellar ataxia (HP:0002073)2.64112333
65Impaired proprioception (HP:0010831)2.62358267
66Ectopic kidney (HP:0000086)2.62282733
67Aplasia/Hypoplasia of the brainstem (HP:0007362)2.60150829
68Hypoplasia of the brainstem (HP:0002365)2.60150829
69Abnormality of the corticospinal tract (HP:0002492)2.57365952
70Stomatitis (HP:0010280)2.55890081
71Distal lower limb muscle weakness (HP:0009053)2.55730263
72Gaze-evoked nystagmus (HP:0000640)2.54532453
73Urinary urgency (HP:0000012)2.54252365
74Areflexia of lower limbs (HP:0002522)2.53483463
75Pendular nystagmus (HP:0012043)2.53036070
76Genetic anticipation (HP:0003743)2.52722229
77Decreased circulating renin level (HP:0003351)2.51459395
78Abnormality of the renal collecting system (HP:0004742)2.50868276
79Peripheral hypomyelination (HP:0007182)2.48246445
80Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48002511
81Hyperventilation (HP:0002883)2.47265183
82Abnormal drinking behavior (HP:0030082)2.44154975
83Polydipsia (HP:0001959)2.44154975
84Decreased central vision (HP:0007663)2.41561294
85Medial flaring of the eyebrow (HP:0010747)2.41497923
86Cystic liver disease (HP:0006706)2.41174804
87Bony spicule pigmentary retinopathy (HP:0007737)2.39145425
88Palpitations (HP:0001962)2.37608113
89Short phalanx of the thumb (HP:0009660)2.36257760
90Abnormal respiratory epithelium morphology (HP:0012253)2.36206875
91Abnormal respiratory motile cilium morphology (HP:0005938)2.36206875
92Abnormal ciliary motility (HP:0012262)2.35325152
93Tubular atrophy (HP:0000092)2.32864265
94Retrobulbar optic neuritis (HP:0100654)2.31704459
95Optic neuritis (HP:0100653)2.31704459
96Ventricular fibrillation (HP:0001663)2.31534510
97Elevated erythrocyte sedimentation rate (HP:0003565)2.23663706
98Amblyopia (HP:0000646)2.22541599
99Hyperkalemia (HP:0002153)2.21603706
100Increased CSF protein (HP:0002922)2.20740280
101Cerebral hemorrhage (HP:0001342)2.20450207
102Arthropathy (HP:0003040)2.18904386
103Absent thumb (HP:0009777)2.17241199
104Facial shape deformation (HP:0011334)2.16452898
105Potter facies (HP:0002009)2.16452898
106Duplicated collecting system (HP:0000081)2.14514508
107Chin dimple (HP:0010751)2.14346592
108Abolished electroretinogram (ERG) (HP:0000550)2.14236277
109Broad-based gait (HP:0002136)2.13284502
110Hypochromic microcytic anemia (HP:0004840)2.12846034
111Type II lissencephaly (HP:0007260)2.10618648
112Focal motor seizures (HP:0011153)2.10425131
113Hypoplastic iliac wings (HP:0002866)2.10347247
114Stomach cancer (HP:0012126)2.06260382
115Abnormality of magnesium homeostasis (HP:0004921)2.04970261
116Urinary bladder sphincter dysfunction (HP:0002839)2.04717455
117Protruding tongue (HP:0010808)2.04021959
118Abnormality of the nasal septum (HP:0000419)2.03963562
119Muscle hypertrophy of the lower extremities (HP:0008968)2.03379022
120Myositis (HP:0100614)2.02788120
121Abnormality of calcium-phosphate metabolism (HP:0100530)2.01998989
122Tachypnea (HP:0002789)2.01039804
123Orchitis (HP:0100796)2.00843057
124Severe visual impairment (HP:0001141)2.00840854
125Limb dystonia (HP:0002451)1.99955855
126Muscle stiffness (HP:0003552)1.99608852
127Spastic gait (HP:0002064)1.99246752
128Gait imbalance (HP:0002141)1.98677845
129Congenital hepatic fibrosis (HP:0002612)1.98515300
130Decreased muscle mass (HP:0003199)1.97448104
131Anencephaly (HP:0002323)1.96857766
132Calf muscle hypertrophy (HP:0008981)1.96597295
133Axonal loss (HP:0003447)1.96045562
134Polyuria (HP:0000103)1.95390971
135Absent phalangeal crease (HP:0006109)1.94942088
136Male pseudohermaphroditism (HP:0000037)1.93683290
137Peripheral demyelination (HP:0011096)1.93296466
138Abnormality of the lower motor neuron (HP:0002366)1.93017603
139Absent speech (HP:0001344)1.92990642
140Rapidly progressive (HP:0003678)1.92613458
141Mask-like facies (HP:0000298)1.91001383
142Truncal ataxia (HP:0002078)1.90442873
143Absence seizures (HP:0002121)1.89952480
144Furrowed tongue (HP:0000221)1.89929855
145EMG: neuropathic changes (HP:0003445)1.89144437
146Toxemia of pregnancy (HP:0100603)1.89074567
147Episodic fever (HP:0001954)1.88841574
148Exotropia (HP:0000577)1.87668351
149Chorioretinal atrophy (HP:0000533)1.87563370
150Keratoconus (HP:0000563)1.85862706
151Increased corneal curvature (HP:0100692)1.85862706
152Overlapping toe (HP:0001845)1.85160470
153Abnormality of the parathyroid morphology (HP:0011766)1.85086605
154Curly hair (HP:0002212)1.82368938
155Down-sloping shoulders (HP:0200021)1.81601884
156Clumsiness (HP:0002312)1.81413906
157Hypomagnesemia (HP:0002917)1.80397939
158Fasciculations (HP:0002380)1.80344081
159Spinal canal stenosis (HP:0003416)1.79992391
160Anosmia (HP:0000458)1.79915657
161Muscle fiber inclusion bodies (HP:0100299)1.79366244
162Constricted visual fields (HP:0001133)1.79180937
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.78309525
164Chronic sinusitis (HP:0011109)1.77760635
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77561189
166Neonatal onset (HP:0003623)1.77357979
167Lower limb muscle weakness (HP:0007340)1.76731645
168Congenital primary aphakia (HP:0007707)1.76676709
169Sclerocornea (HP:0000647)1.76207778
170Popliteal pterygium (HP:0009756)1.75781052
171Visual hallucinations (HP:0002367)1.75235822
172Stenosis of the external auditory canal (HP:0000402)1.75181155
173Neuroblastic tumors (HP:0004376)1.74943747
174Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.74943747
175Neuroblastoma (HP:0003006)1.74943747
176Primitive neuroectodermal tumor (HP:0030065)1.74943747
177Abnormality of DNA repair (HP:0003254)1.73011217
178Abnormal respiratory motile cilium physiology (HP:0012261)1.71975137
179Aqueductal stenosis (HP:0002410)1.71423219
180Dialeptic seizures (HP:0011146)1.70837626
181Tented upper lip vermilion (HP:0010804)1.70792443
182Menstrual irregularities (HP:0000858)1.70092462
183Chronic otitis media (HP:0000389)1.69915851
184Paraplegia (HP:0010550)1.69863166
185Hyperparathyroidism (HP:0000843)1.69857362
186Ketoacidosis (HP:0001993)1.69849481
187Ketosis (HP:0001946)1.69817674
188Aplasia/Hypoplasia of the spleen (HP:0010451)1.69323998
189Retinitis pigmentosa (HP:0000510)1.69209088
190Abnormal urine output (HP:0012590)1.69082225
191Clubbing of toes (HP:0100760)1.68143930
192Severe muscular hypotonia (HP:0006829)1.66857808
193Frequent falls (HP:0002359)1.66679602
194Macroglossia (HP:0000158)1.65327079
195Thyroiditis (HP:0100646)1.64760149
196Keratitis (HP:0000491)1.63903463
197Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62341082
198Abnormality of renin-angiotensin system (HP:0000847)1.61506148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.59060114
2LMTK24.09136231
3KSR23.71467909
4MAP3K23.31298112
5MINK13.21937482
6LIMK13.17500682
7MAP3K93.06378752
8MATK3.04036152
9MAPKAPK32.97828565
10NTRK32.80167402
11TEC2.78035208
12ADRBK22.68054835
13TAOK32.57856564
14GRK52.54334360
15OBSCN2.38504983
16RET2.30434911
17LATS22.23333016
18RIPK42.16823824
19MAP3K122.16347247
20ACVR1B2.15389859
21GRK12.14054018
22EPHA32.02627981
23ARAF1.94746892
24ITK1.93924673
25MAP2K11.87257794
26WNK31.85797651
27NUAK11.72279119
28TNK21.64450336
29YES11.63233477
30PHKG21.60711544
31PHKG11.60711544
32SIK21.57048253
33BTK1.53581270
34RPS6KA21.46384272
35MAP2K21.41006317
36SIK31.37746659
37FER1.34776189
38TXK1.32604296
39INSRR1.30501357
40MAP3K11.23477392
41MAPKAPK51.18393431
42MAP3K71.16802165
43PIM21.13512990
44FRK1.12700283
45MAP2K41.12561025
46MAP4K21.12136688
47MAP3K41.11912746
48PAK61.10760284
49ZAK1.08071881
50WNK11.07637405
51IRAK11.06095512
52DAPK21.05225838
53MARK21.03114529
54TESK11.02498421
55IRAK41.02125892
56SGK4940.98768608
57SGK2230.98768608
58PIK3CG0.97580031
59MARK30.95006096
60NME10.94922908
61NEK90.94560067
62RPS6KB20.93449098
63PRKG20.93330921
64OXSR10.90915711
65CAMKK20.90631078
66SCYL20.88866218
67ERBB30.88463166
68CSK0.87351581
69PRKAA20.87311489
70ADRBK10.86424837
71MUSK0.86147118
72GRK60.84961410
73MAPK130.84579621
74MARK10.83702207
75STK110.83335316
76AKT30.81146761
77MAP2K70.79592581
78IKBKB0.78928587
79SYK0.78521260
80STK240.76969929
81PRKAA10.76527142
82CASK0.76496852
83FGFR30.72877225
84TRPM70.72798591
85PRKCE0.72733949
86STK390.72294346
87EPHB10.71806334
88SGK20.71060764
89PRKD20.70794589
90CDK50.69261712
91DYRK1B0.68908883
92NEK10.68597598
93PIK3CA0.68045994
94PTK20.67823073
95CHUK0.67494702
96IKBKE0.66817282
97LYN0.65068500
98CAMKK10.64946469
99EEF2K0.64910137
100CSNK1G20.64210892
101NLK0.64097035
102TLK10.63091772
103WNK40.62850288
104GRK70.62204959
105CAMK1D0.62140877
106CSNK1G30.61467535
107CAMK10.61200417
108SGK30.59302403
109BLK0.58314235
110MAP4K10.57986839
111ERBB20.56474964
112CDK140.56467260
113PKN10.55553103
114DYRK1A0.54669842
115PTK2B0.54291662
116HCK0.54093902
117SGK10.52065679
118MAPK120.52033602
119KSR10.51373581
120MST40.50456394
121TYK20.50067099
122UHMK10.49562918
123MAP3K110.48550403
124FGFR40.48485595
125MAP2K30.48395160
126TSSK60.48213939
127PRKCQ0.47918460
128LRRK20.47720725
129PRKCI0.45242220
130PRKG10.43896063
131FGFR20.43509485
132KIT0.42121616
133NTRK20.40948613
134DYRK30.40304595
135MAPKAPK20.38669587
136MAP2K60.38082770
137PRKCG0.37690321
138CAMK40.37668619
139MAPK150.37081449
140BMPR1B0.35917925
141CAMK2G0.35664560
142SRC0.35547689
143ERBB40.35243896
144CAMK2D0.34003420
145PINK10.33140877
146PRKACA0.32124750
147ROCK10.31185546
148CSNK1A1L0.31057087
149CAMK2A0.30885145
150TAOK10.30082441
151PDPK10.30060922
152TRIB30.29814127
153PRKCZ0.28873137
154PDK10.28864293
155PRKACG0.28815798
156CDC42BPA0.28679950
157PRKCH0.28271147
158PAK30.26853215
159EPHB20.26647981
160ROCK20.26152684
161DYRK20.25870521
162ZAP700.25471426
163CDK180.24975516

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.38076510
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.33261032
3Synaptic vesicle cycle_Homo sapiens_hsa047213.07731597
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.66159493
5Linoleic acid metabolism_Homo sapiens_hsa005912.63602836
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.46542482
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.25697293
8Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.14399519
9Thyroid cancer_Homo sapiens_hsa052162.12828069
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.10031342
11Phototransduction_Homo sapiens_hsa047442.08060956
12Taste transduction_Homo sapiens_hsa047422.03833259
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.96022578
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87806586
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.84410417
16Renin-angiotensin system_Homo sapiens_hsa046141.81752530
17Ether lipid metabolism_Homo sapiens_hsa005651.79750296
18Nitrogen metabolism_Homo sapiens_hsa009101.78183376
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.75314808
20Olfactory transduction_Homo sapiens_hsa047401.72576764
21Dorso-ventral axis formation_Homo sapiens_hsa043201.72472770
22Collecting duct acid secretion_Homo sapiens_hsa049661.63427334
23Insulin secretion_Homo sapiens_hsa049111.61779859
24Dopaminergic synapse_Homo sapiens_hsa047281.56170760
25Nicotine addiction_Homo sapiens_hsa050331.54633535
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54605103
27Cholinergic synapse_Homo sapiens_hsa047251.50923970
28Tryptophan metabolism_Homo sapiens_hsa003801.48584213
29ABC transporters_Homo sapiens_hsa020101.43042820
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.41965279
31Morphine addiction_Homo sapiens_hsa050321.40857973
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39542095
33Serotonergic synapse_Homo sapiens_hsa047261.35868459
34Arachidonic acid metabolism_Homo sapiens_hsa005901.32720812
35Circadian rhythm_Homo sapiens_hsa047101.29448254
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28955243
37Butanoate metabolism_Homo sapiens_hsa006501.25697259
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.24948663
39Vibrio cholerae infection_Homo sapiens_hsa051101.24493086
40GnRH signaling pathway_Homo sapiens_hsa049121.24214565
41Long-term potentiation_Homo sapiens_hsa047201.22847534
42VEGF signaling pathway_Homo sapiens_hsa043701.22633281
43Gastric acid secretion_Homo sapiens_hsa049711.19128820
44Caffeine metabolism_Homo sapiens_hsa002321.18956635
45Pancreatic secretion_Homo sapiens_hsa049721.18256482
46Glioma_Homo sapiens_hsa052141.16961770
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16420486
48Insulin signaling pathway_Homo sapiens_hsa049101.14483236
49Salivary secretion_Homo sapiens_hsa049701.13750534
50Salmonella infection_Homo sapiens_hsa051321.08340093
51Gap junction_Homo sapiens_hsa045401.06442290
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06406986
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.05605527
54Prolactin signaling pathway_Homo sapiens_hsa049171.05341904
55Chemical carcinogenesis_Homo sapiens_hsa052041.04152119
56Endometrial cancer_Homo sapiens_hsa052131.03825548
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03116520
58Ovarian steroidogenesis_Homo sapiens_hsa049131.02351460
59Cardiac muscle contraction_Homo sapiens_hsa042601.02058701
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01697040
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00089165
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.95876333
63Estrogen signaling pathway_Homo sapiens_hsa049150.95019324
64Melanoma_Homo sapiens_hsa052180.94816438
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.94453843
66Circadian entrainment_Homo sapiens_hsa047130.93484428
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.93319774
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92733750
69Parkinsons disease_Homo sapiens_hsa050120.91555434
70Osteoclast differentiation_Homo sapiens_hsa043800.91176043
71Regulation of autophagy_Homo sapiens_hsa041400.91112051
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90816269
73Oxidative phosphorylation_Homo sapiens_hsa001900.89656769
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.89028329
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88829470
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88768405
77Primary immunodeficiency_Homo sapiens_hsa053400.88449316
78Bile secretion_Homo sapiens_hsa049760.88270537
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87891498
80Endocytosis_Homo sapiens_hsa041440.87352298
81Lysine degradation_Homo sapiens_hsa003100.86752310
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86653173
83FoxO signaling pathway_Homo sapiens_hsa040680.86474320
84ErbB signaling pathway_Homo sapiens_hsa040120.85449628
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85378075
86Selenocompound metabolism_Homo sapiens_hsa004500.84496537
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.84162255
88Thyroid hormone synthesis_Homo sapiens_hsa049180.83650827
89Long-term depression_Homo sapiens_hsa047300.83330794
90Mineral absorption_Homo sapiens_hsa049780.82812959
91African trypanosomiasis_Homo sapiens_hsa051430.82494391
92Steroid biosynthesis_Homo sapiens_hsa001000.78777451
93Glutamatergic synapse_Homo sapiens_hsa047240.78625350
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78211604
95Phagosome_Homo sapiens_hsa041450.78169662
96Type II diabetes mellitus_Homo sapiens_hsa049300.77885733
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75741130
98GABAergic synapse_Homo sapiens_hsa047270.74961665
99Staphylococcus aureus infection_Homo sapiens_hsa051500.74898305
100Alzheimers disease_Homo sapiens_hsa050100.74440988
101Amphetamine addiction_Homo sapiens_hsa050310.74401008
102T cell receptor signaling pathway_Homo sapiens_hsa046600.74208736
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72265941
104Insulin resistance_Homo sapiens_hsa049310.70664408
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.69624318
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68878794
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.67764478
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66711501
109Melanogenesis_Homo sapiens_hsa049160.66486172
110Oxytocin signaling pathway_Homo sapiens_hsa049210.65895588
111Calcium signaling pathway_Homo sapiens_hsa040200.65462809
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65333696
113Histidine metabolism_Homo sapiens_hsa003400.65154061
114Fanconi anemia pathway_Homo sapiens_hsa034600.64471817
115Renin secretion_Homo sapiens_hsa049240.64364309
116Choline metabolism in cancer_Homo sapiens_hsa052310.63080638
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.62452863
118Oocyte meiosis_Homo sapiens_hsa041140.61578396
119Rap1 signaling pathway_Homo sapiens_hsa040150.60717021
120Protein digestion and absorption_Homo sapiens_hsa049740.58435925
121Retinol metabolism_Homo sapiens_hsa008300.57840919
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56703280
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56122709
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55319737
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55147998
126mTOR signaling pathway_Homo sapiens_hsa041500.54866823
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54779634
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.54228670
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53903144
130Axon guidance_Homo sapiens_hsa043600.53503747
131Peroxisome_Homo sapiens_hsa041460.53035275
132Chemokine signaling pathway_Homo sapiens_hsa040620.52859806
133Glycerolipid metabolism_Homo sapiens_hsa005610.51947322
134cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50828883
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.50683889
136Ras signaling pathway_Homo sapiens_hsa040140.50162582
137Sulfur metabolism_Homo sapiens_hsa009200.49952880
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49776828
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49471657
140TNF signaling pathway_Homo sapiens_hsa046680.49091448
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.47931880
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47587666
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46995425
144Non-small cell lung cancer_Homo sapiens_hsa052230.46750591
145Cocaine addiction_Homo sapiens_hsa050300.46419774
146Measles_Homo sapiens_hsa051620.46179957
147Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45519398
148MAPK signaling pathway_Homo sapiens_hsa040100.44169953
149Pyruvate metabolism_Homo sapiens_hsa006200.43906121
150Hematopoietic cell lineage_Homo sapiens_hsa046400.43237339
151Glucagon signaling pathway_Homo sapiens_hsa049220.43179015
152Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41862373
153Tyrosine metabolism_Homo sapiens_hsa003500.40410714
154cAMP signaling pathway_Homo sapiens_hsa040240.40036708
155Platelet activation_Homo sapiens_hsa046110.39736606
156Bladder cancer_Homo sapiens_hsa052190.39572887
157Fructose and mannose metabolism_Homo sapiens_hsa000510.39491033
158Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38659417
159Prion diseases_Homo sapiens_hsa050200.36939944
160Shigellosis_Homo sapiens_hsa051310.36646832

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