AVL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of hippo signaling (GO:0035330)4.68766134
2interkinetic nuclear migration (GO:0022027)4.67414116
3protein K48-linked deubiquitination (GO:0071108)4.61131491
4COPI coating of Golgi vesicle (GO:0048205)4.60773758
5Golgi transport vesicle coating (GO:0048200)4.60773758
6positive regulation of fatty acid beta-oxidation (GO:0032000)4.46300005
7monoubiquitinated protein deubiquitination (GO:0035520)4.45267347
8regulation of establishment of cell polarity (GO:2000114)4.21113475
9positive regulation of fatty acid oxidation (GO:0046321)4.17108100
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.15801380
11striated muscle atrophy (GO:0014891)3.96005670
12synaptic vesicle maturation (GO:0016188)3.91124235
13protein targeting to Golgi (GO:0000042)3.88163737
14snRNA transcription (GO:0009301)3.87577635
15behavioral response to nicotine (GO:0035095)3.87391226
16cytoplasmic mRNA processing body assembly (GO:0033962)3.85247731
17establishment of protein localization to Golgi (GO:0072600)3.83875568
18regulation of ARF protein signal transduction (GO:0032012)3.80972587
19negative regulation of sodium ion transport (GO:0010766)3.80327649
20regulation of fatty acid beta-oxidation (GO:0031998)3.78658211
21serotonin metabolic process (GO:0042428)3.76755306
22regulation of establishment or maintenance of cell polarity (GO:0032878)3.59299386
23nerve growth factor signaling pathway (GO:0038180)3.57910969
24indolalkylamine metabolic process (GO:0006586)3.57395065
25retrograde transport, vesicle recycling within Golgi (GO:0000301)3.56565102
26macroautophagy (GO:0016236)3.54056193
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.52322651
28layer formation in cerebral cortex (GO:0021819)3.51202001
29primary amino compound metabolic process (GO:1901160)3.49856876
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45848181
31kynurenine metabolic process (GO:0070189)3.42890992
32locomotory exploration behavior (GO:0035641)3.42724933
33regulation of posttranscriptional gene silencing (GO:0060147)3.41629334
34regulation of gene silencing by miRNA (GO:0060964)3.41629334
35regulation of gene silencing by RNA (GO:0060966)3.41629334
36tryptophan catabolic process (GO:0006569)3.31228620
37indole-containing compound catabolic process (GO:0042436)3.31228620
38indolalkylamine catabolic process (GO:0046218)3.31228620
39muscle atrophy (GO:0014889)3.30540522
40vesicle transport along microtubule (GO:0047496)3.23088587
41positive regulation of developmental pigmentation (GO:0048087)3.21498120
42vesicle coating (GO:0006901)3.21319597
43stress granule assembly (GO:0034063)3.18608797
44cellular response to ATP (GO:0071318)3.18066372
45regulation of synaptic vesicle exocytosis (GO:2000300)3.16596266
46regulation of pigment cell differentiation (GO:0050932)3.15855562
47gamma-aminobutyric acid transport (GO:0015812)3.15554298
48proline transport (GO:0015824)3.13190716
49peptidyl-threonine dephosphorylation (GO:0035970)3.07638583
50flavonoid metabolic process (GO:0009812)3.07280277
51response to lipoprotein particle (GO:0055094)3.03775615
52histone H3-K9 demethylation (GO:0033169)3.02650689
53sulfation (GO:0051923)3.00616956
54activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.00491570
55activation of protein kinase A activity (GO:0034199)2.99772531
56hepatocyte apoptotic process (GO:0097284)2.98570881
57indole-containing compound metabolic process (GO:0042430)2.97043663
58regulation of clathrin-mediated endocytosis (GO:2000369)2.96968138
59protein localization to endosome (GO:0036010)2.96929410
60endoplasmic reticulum organization (GO:0007029)2.95259836
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93357728
62negative regulation of cell killing (GO:0031342)2.93357728
63lipid translocation (GO:0034204)2.90678845
64phospholipid translocation (GO:0045332)2.90678845
65replicative senescence (GO:0090399)2.90456388
66interferon-gamma secretion (GO:0072643)2.88938940
67cellular response to ethanol (GO:0071361)2.88880658
68clathrin coat assembly (GO:0048268)2.87754638
69purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.87031322
703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.87031322
71regulation of interleukin-12 biosynthetic process (GO:0045075)2.86806992
72dendrite morphogenesis (GO:0048813)2.86067680
73L-fucose catabolic process (GO:0042355)2.85169691
74fucose catabolic process (GO:0019317)2.85169691
75L-fucose metabolic process (GO:0042354)2.85169691
76protein K11-linked deubiquitination (GO:0035871)2.84048486
77cellular response to exogenous dsRNA (GO:0071360)2.83906984
78sodium ion export (GO:0071436)2.82077381
79growth hormone receptor signaling pathway (GO:0060396)2.81595776
80cellular potassium ion homeostasis (GO:0030007)2.81383784
81protein targeting to lysosome (GO:0006622)2.81118388
82establishment of protein localization to vacuole (GO:0072666)2.81118388
83protein targeting to vacuole (GO:0006623)2.81118388
84prostate gland growth (GO:0060736)2.80939383
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80284139
86positive regulation of nuclease activity (GO:0032075)2.80027524
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80010348
88negative regulation of glycogen biosynthetic process (GO:0045719)2.79117543
89endocardial cushion development (GO:0003197)2.76139961
90skeletal muscle adaptation (GO:0043501)2.76139496
91positive regulation of CREB transcription factor activity (GO:0032793)2.76051556
92tryptophan metabolic process (GO:0006568)2.73787002
93negative regulation of systemic arterial blood pressure (GO:0003085)2.73328870
94inner ear receptor cell development (GO:0060119)2.73177974
95glutamate secretion (GO:0014047)2.72349740
96phosphatidylethanolamine biosynthetic process (GO:0006646)2.70599945
97glial cell proliferation (GO:0014009)2.70580487
98peptidyl-lysine dimethylation (GO:0018027)2.67149843
99intra-Golgi vesicle-mediated transport (GO:0006891)2.67147669
100negative regulation of TOR signaling (GO:0032007)2.64890480
101protein import into peroxisome matrix (GO:0016558)2.62396572
102iron ion import (GO:0097286)2.62191913
103cell proliferation in forebrain (GO:0021846)2.59425641
104phosphatidylethanolamine metabolic process (GO:0046337)2.59333517
105protein K63-linked deubiquitination (GO:0070536)2.58439890
106insulin secretion (GO:0030073)2.57523157
107membrane repolarization during action potential (GO:0086011)2.57502153
108cerebellar Purkinje cell differentiation (GO:0021702)2.56791321
109peptidyl-threonine phosphorylation (GO:0018107)2.56490416
110UDP-N-acetylglucosamine metabolic process (GO:0006047)2.56447239
111organelle transport along microtubule (GO:0072384)2.56131999
112regulation of nuclease activity (GO:0032069)2.56046264
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.56018405
114peptidyl-threonine modification (GO:0018210)2.55999957
115regulation of fatty acid oxidation (GO:0046320)2.55926043
116neural tube formation (GO:0001841)2.54856746
117regulation of growth hormone secretion (GO:0060123)2.54676032
118insulin-like growth factor receptor signaling pathway (GO:0048009)2.54299973
119phosphatidylinositol phosphorylation (GO:0046854)2.53446649
120regulation of synaptic vesicle transport (GO:1902803)2.52610039
121negative regulation of mast cell activation (GO:0033004)2.52077259
122histone H3-K9 methylation (GO:0051567)2.51961771
123respiratory tube development (GO:0030323)2.51957715
124cerebellar Purkinje cell layer development (GO:0021680)2.51616313
125negative regulation of fatty acid transport (GO:2000192)2.51020968
126phosphorelay signal transduction system (GO:0000160)2.50304045
127positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.49659812
128endoplasmic reticulum unfolded protein response (GO:0030968)2.48943590
129cellular response to nerve growth factor stimulus (GO:1990090)2.47270031
130response to nerve growth factor (GO:1990089)2.47270031
131thyroid hormone metabolic process (GO:0042403)2.47195858
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46259313
133synaptic vesicle exocytosis (GO:0016079)2.45729566
134establishment of nucleus localization (GO:0040023)2.45209520
135positive regulation of histone deacetylation (GO:0031065)2.44408101
136detection of light stimulus involved in sensory perception (GO:0050962)2.42747238
137detection of light stimulus involved in visual perception (GO:0050908)2.42747238
138kidney morphogenesis (GO:0060993)2.42671462
139neurotransmitter secretion (GO:0007269)2.42235822
140COPII vesicle coating (GO:0048208)2.41374520
141intestinal epithelial cell development (GO:0060576)2.40843302
142phosphatidylinositol 3-kinase signaling (GO:0014065)2.40165801
143DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.39410368
144cellular response to unfolded protein (GO:0034620)2.38855974
145potassium ion import (GO:0010107)2.38629552
146ER-nucleus signaling pathway (GO:0006984)2.38353480
147histone H3-K36 demethylation (GO:0070544)2.36932561
148embryonic epithelial tube formation (GO:0001838)2.36647807
149positive regulation of phosphatase activity (GO:0010922)2.36360543
150gamma-aminobutyric acid signaling pathway (GO:0007214)2.35454060
151receptor catabolic process (GO:0032801)2.34966615
152cellular response to growth hormone stimulus (GO:0071378)2.33880733
153negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.32681778
154negative regulation of protein tyrosine kinase activity (GO:0061099)2.32629332
155lipid phosphorylation (GO:0046834)2.31694706
156negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.31353172
157N-glycan processing (GO:0006491)2.30072080
158protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.29615845
159alanine transport (GO:0032328)2.29448121
160endosome to melanosome transport (GO:0035646)2.28866844
161endosome to pigment granule transport (GO:0043485)2.28866844
162negative regulation of organelle assembly (GO:1902116)2.28197884
163phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.26050956
164regulation of calcium ion-dependent exocytosis (GO:0017158)2.24951169
165antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.24526431
166antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.24526431
167suckling behavior (GO:0001967)2.24108103
168regulation of nucleobase-containing compound transport (GO:0032239)2.23665437
169exploration behavior (GO:0035640)2.23121281
170positive regulation of Rap GTPase activity (GO:0032854)2.22154678
171pre-miRNA processing (GO:0031054)2.21353791
172Golgi organization (GO:0007030)2.21106836
173positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.20647177
174endocrine pancreas development (GO:0031018)2.20154790
175regulation of Rap GTPase activity (GO:0032317)2.19933728
176JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.19533991
177cellular response to topologically incorrect protein (GO:0035967)2.19484199
178regulation of ARF GTPase activity (GO:0032312)2.19391616
179synaptic vesicle docking involved in exocytosis (GO:0016081)2.19192317
180prepulse inhibition (GO:0060134)2.18883890
181regulation of Rac protein signal transduction (GO:0035020)2.17981255
182regulation of RNA export from nucleus (GO:0046831)2.16720709
183innervation (GO:0060384)2.15888394
184regulation of gamma-delta T cell differentiation (GO:0045586)2.14838424
185positive regulation of growth hormone secretion (GO:0060124)2.14374344
186neuromuscular process controlling balance (GO:0050885)2.13269911
187regulation of neuronal synaptic plasticity (GO:0048168)2.13174983
188membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.12758758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18009714
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.94303256
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81673337
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.74116237
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.37213936
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18598411
7TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.17451287
8GATA1_22025678_ChIP-Seq_K562_Human2.16632507
9* ER_23166858_ChIP-Seq_MCF-7_Human2.10796888
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.09760806
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04946942
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03406150
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01089433
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97103669
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92654719
16SALL1_21062744_ChIP-ChIP_HESCs_Human1.92224654
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80832572
18RARB_27405468_Chip-Seq_BRAIN_Mouse1.77549767
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74297249
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73516889
21IRF1_19129219_ChIP-ChIP_H3396_Human1.72024376
22DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68274641
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66985282
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.60369225
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.59675069
26DROSHA_22980978_ChIP-Seq_HELA_Human1.59458090
27KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59416595
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57603407
29FOXM1_26456572_ChIP-Seq_MCF-7_Human1.57519679
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55457899
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54343178
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53532533
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47862346
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46687368
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45881042
36KDM2B_26808549_Chip-Seq_K562_Human1.43215649
37TAF15_26573619_Chip-Seq_HEK293_Human1.42596753
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41603108
39AHR_22903824_ChIP-Seq_MCF-7_Human1.40239996
40* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39282624
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38671397
42TCF7_22412390_ChIP-Seq_EML_Mouse1.38157148
43ARNT_22903824_ChIP-Seq_MCF-7_Human1.37028735
44EZH2_22144423_ChIP-Seq_EOC_Human1.34973593
45FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.34859464
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34542403
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33216281
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32854981
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31548960
50* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31093521
51KDM2B_26808549_Chip-Seq_DND41_Human1.29069664
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28359559
53ZNF274_21170338_ChIP-Seq_K562_Hela1.28012831
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.25490536
55REST_21632747_ChIP-Seq_MESCs_Mouse1.25325623
56SCL_19346495_ChIP-Seq_HPC-7_Human1.24667728
57MYC_22102868_ChIP-Seq_BL_Human1.23894018
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23708918
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.23524186
60RUNX_20019798_ChIP-Seq_JUKART_Human1.21864124
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21725037
62STAT3_23295773_ChIP-Seq_U87_Human1.20346101
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20012116
64CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19812570
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.19497661
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19117939
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18645463
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18645463
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18643036
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.18391115
71CLOCK_20551151_ChIP-Seq_293T_Human1.17776066
72* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17038174
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14824330
74TP53_16413492_ChIP-PET_HCT116_Human1.14727253
75ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14520942
76AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13972694
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12951028
78WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12269374
79RXR_22108803_ChIP-Seq_LS180_Human1.11218612
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10243694
81SMAD4_21799915_ChIP-Seq_A2780_Human1.10237587
82FLI1_21867929_ChIP-Seq_TH2_Mouse1.10201729
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.10161350
84ZNF263_19887448_ChIP-Seq_K562_Human1.10151567
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.09746572
86GATA3_27048872_Chip-Seq_THYMUS_Human1.09124414
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08034670
88FOXA1_25552417_ChIP-Seq_VCAP_Human1.07549276
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07506889
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07152034
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07032231
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06416113
93GATA1_19941826_ChIP-Seq_K562_Human1.05646166
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05169678
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03535249
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02811525
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02400466
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01979592
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.01768849
100AR_19668381_ChIP-Seq_PC3_Human1.01328793
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01139915
102CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01003661
103P300_19829295_ChIP-Seq_ESCs_Human1.00688703
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00393118
105* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00074349
106OCT1_27270436_Chip-Seq_PROSTATE_Human0.99977224
107VDR_22108803_ChIP-Seq_LS180_Human0.99328075
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99208567
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99131640
110KDM2B_26808549_Chip-Seq_REH_Human0.99020197
111TCF4_18268006_ChIP-ChIP_LS174T_Human0.97844080
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96754507
113AR_25329375_ChIP-Seq_VCAP_Human0.96338362
114MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96089197
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96030543
116* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96022132
117FUS_26573619_Chip-Seq_HEK293_Human0.95604478
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95161967
119CBP_20019798_ChIP-Seq_JUKART_Human0.95161967
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94953634
121EWS_26573619_Chip-Seq_HEK293_Human0.94139874
122GBX2_23144817_ChIP-Seq_PC3_Human0.93965931
123BCAT_22108803_ChIP-Seq_LS180_Human0.93877673
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93307858
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.93149966
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92935012
127* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92734641
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92093712
129Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91799400
130AR_21572438_ChIP-Seq_LNCaP_Human0.91030813
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.90178690
132CDX2_22108803_ChIP-Seq_LS180_Human0.90062141
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.89676279
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89416142
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89176373
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89070892
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88935560
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88766448
139TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88633930
140E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88496028
141TCF4_23295773_ChIP-Seq_U87_Human0.88063408
142IGF1R_20145208_ChIP-Seq_DFB_Human0.87514317
143REST_18959480_ChIP-ChIP_MESCs_Mouse0.87279745
144NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87194142
145RNF2_27304074_Chip-Seq_ESCs_Mouse0.87179869
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86337986
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.86301015
148IRF8_22096565_ChIP-ChIP_GC-B_Human0.85799347
149CREB1_26743006_Chip-Seq_LNCaP_Human0.85637642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.02394219
2MP0003646_muscle_fatigue5.01865666
3MP0000569_abnormal_digit_pigmentation4.05654008
4MP0003300_gastrointestinal_ulcer3.88636857
5MP0008057_abnormal_DNA_replication3.87896863
6MP0002877_abnormal_melanocyte_morpholog3.86911405
7MP0004859_abnormal_synaptic_plasticity3.23815565
8MP0000383_abnormal_hair_follicle3.17578208
9MP0002837_dystrophic_cardiac_calcinosis3.03882685
10MP0002909_abnormal_adrenal_gland3.02905406
11MP0003183_abnormal_peptide_metabolism2.76822482
12MP0009780_abnormal_chondrocyte_physiolo2.58636670
13MP0008961_abnormal_basal_metabolism2.47515911
14MP0000427_abnormal_hair_cycle2.31891661
15MP0000537_abnormal_urethra_morphology2.26654869
16MP0003787_abnormal_imprinting2.13367718
17MP0004270_analgesia2.06254796
18MP0003172_abnormal_lysosome_physiology2.01066868
19MP0004885_abnormal_endolymph1.95513497
20MP0002166_altered_tumor_susceptibility1.94014129
21MP0003635_abnormal_synaptic_transmissio1.93314067
22MP0002160_abnormal_reproductive_system1.92570865
23MP0003045_fibrosis1.89550729
24MP0002693_abnormal_pancreas_physiology1.89294341
25MP0001944_abnormal_pancreas_morphology1.87573830
26MP0004264_abnormal_extraembryonic_tissu1.85448430
27MP0001873_stomach_inflammation1.80025072
28MP0005076_abnormal_cell_differentiation1.79131049
29MP0003303_peritoneal_inflammation1.78875829
30MP0002009_preneoplasia1.77138016
31MP0003283_abnormal_digestive_organ1.71190891
32MP0009053_abnormal_anal_canal1.68567162
33MP0010352_gastrointestinal_tract_polyps1.60191417
34MP0002063_abnormal_learning/memory/cond1.52752892
35MP0005220_abnormal_exocrine_pancreas1.51463058
36MP0009115_abnormal_fat_cell1.49752498
37MP0003868_abnormal_feces_composition1.47981955
38MP0005389_reproductive_system_phenotype1.47082652
39MP0003866_abnormal_defecation1.47013266
40MP0001968_abnormal_touch/_nociception1.46187731
41MP0004858_abnormal_nervous_system1.44881025
42MP0000013_abnormal_adipose_tissue1.43834489
43MP0005310_abnormal_salivary_gland1.42361134
44MP0005187_abnormal_penis_morphology1.38912782
45MP0010678_abnormal_skin_adnexa1.37967796
46MP0005423_abnormal_somatic_nervous1.37885244
47MP0000470_abnormal_stomach_morphology1.33038279
48MP0004043_abnormal_pH_regulation1.32433401
49MP0004233_abnormal_muscle_weight1.32430002
50MP0001664_abnormal_digestion1.30505969
51MP0001348_abnormal_lacrimal_gland1.30387343
52MP0005248_abnormal_Harderian_gland1.27710792
53MP0003329_amyloid_beta_deposits1.27255159
54MP0002006_tumorigenesis1.26846256
55MP0002736_abnormal_nociception_after1.26580948
56MP0002928_abnormal_bile_duct1.25158597
57MP0004811_abnormal_neuron_physiology1.25136453
58MP0001919_abnormal_reproductive_system1.24463498
59MP0001299_abnormal_eye_distance/1.23429917
60MP0002822_catalepsy1.21044327
61MP0000604_amyloidosis1.18822814
62MP0000631_abnormal_neuroendocrine_gland1.18193762
63MP0005408_hypopigmentation1.17855984
64MP0008775_abnormal_heart_ventricle1.17170543
65MP0003937_abnormal_limbs/digits/tail_de1.17141857
66MP0001485_abnormal_pinna_reflex1.16805144
67MP0002876_abnormal_thyroid_physiology1.16737070
68MP0002254_reproductive_system_inflammat1.16030694
69MP0010307_abnormal_tumor_latency1.15344022
70MP0003632_abnormal_nervous_system1.14130112
71MP0001666_abnormal_nutrient_absorption1.12927736
72MP0002078_abnormal_glucose_homeostasis1.11002327
73MP0003252_abnormal_bile_duct1.10569237
74MP0002735_abnormal_chemical_nociception1.10391926
75MP0008872_abnormal_physiological_respon1.10141886
76MP0009745_abnormal_behavioral_response1.09381915
77MP0001849_ear_inflammation1.08356186
78MP0000371_diluted_coat_color1.07798642
79MP0002064_seizures1.07643025
80MP0000003_abnormal_adipose_tissue1.07419685
81MP0005409_darkened_coat_color1.07084006
82MP0003195_calcinosis1.06671328
83MP0005645_abnormal_hypothalamus_physiol1.06398691
84MP0001501_abnormal_sleep_pattern1.05643715
85MP0008877_abnormal_DNA_methylation1.03370037
86MP0001984_abnormal_olfaction1.03296532
87MP0000428_abnormal_craniofacial_morphol1.02968409
88MP0005551_abnormal_eye_electrophysiolog1.02381376
89MP0003633_abnormal_nervous_system1.00195032
90MP0003690_abnormal_glial_cell0.99963081
91MP0002089_abnormal_postnatal_growth/wei0.99806386
92MP0002734_abnormal_mechanical_nocicepti0.99041405
93MP0004947_skin_inflammation0.98758216
94MP0003942_abnormal_urinary_system0.98644203
95MP0002184_abnormal_innervation0.97381029
96MP0005058_abnormal_lysosome_morphology0.97080411
97MP0000778_abnormal_nervous_system0.96952436
98MP0003123_paternal_imprinting0.96310265
99MP0002090_abnormal_vision0.95711480
100MP0005647_abnormal_sex_gland0.95556429
101MP0002098_abnormal_vibrissa_morphology0.94038920
102MP0002896_abnormal_bone_mineralization0.92432479
103MP0001502_abnormal_circadian_rhythm0.92149726
104MP0010386_abnormal_urinary_bladder0.89995148
105MP0005365_abnormal_bile_salt0.89180457
106MP0002572_abnormal_emotion/affect_behav0.87858241
107MP0005167_abnormal_blood-brain_barrier0.87448338
108MP0003936_abnormal_reproductive_system0.87348544
109MP0002733_abnormal_thermal_nociception0.86125296
110MP0004145_abnormal_muscle_electrophysio0.85940529
111MP0002557_abnormal_social/conspecific_i0.85783095
112MP0005174_abnormal_tail_pigmentation0.85119998
113MP0001765_abnormal_ion_homeostasis0.83875992
114MP0005266_abnormal_metabolism0.83449168
115MP0008569_lethality_at_weaning0.83369458
116MP0000955_abnormal_spinal_cord0.82291283
117MP0010329_abnormal_lipoprotein_level0.81508422
118MP0002272_abnormal_nervous_system0.81148379
119MP0001486_abnormal_startle_reflex0.80743138
120MP0004381_abnormal_hair_follicle0.79976869
121MP0005670_abnormal_white_adipose0.79606385
122MP0005646_abnormal_pituitary_gland0.79232782
123MP0000377_abnormal_hair_follicle0.78343881
124MP0003119_abnormal_digestive_system0.76967613
125MP0005334_abnormal_fat_pad0.76879726
126MP0000538_abnormal_urinary_bladder0.76702540
127MP0002138_abnormal_hepatobiliary_system0.74700284
128MP0005448_abnormal_energy_balance0.74627477
129MP0004134_abnormal_chest_morphology0.73217323
130MP0004924_abnormal_behavior0.72746064
131MP0005386_behavior/neurological_phenoty0.72746064
132MP0000627_abnormal_mammary_gland0.71516531
133MP0001177_atelectasis0.70288284
134MP0009046_muscle_twitch0.70213190
135MP0005379_endocrine/exocrine_gland_phen0.69367686
136MP0005666_abnormal_adipose_tissue0.68503774
137MP0004185_abnormal_adipocyte_glucose0.67641844
138MP0003890_abnormal_embryonic-extraembry0.67487189
139MP0002075_abnormal_coat/hair_pigmentati0.65700372
140MP0002882_abnormal_neuron_morphology0.65661030
141MP0002168_other_aberrant_phenotype0.65292953
142MP0003879_abnormal_hair_cell0.64111333
143MP0004130_abnormal_muscle_cell0.64008367
144MP0003091_abnormal_cell_migration0.63673150
145MP0009703_decreased_birth_body0.63564635
146MP0003953_abnormal_hormone_level0.62663017
147MP0003634_abnormal_glial_cell0.62286480
148MP0003631_nervous_system_phenotype0.62117148
149MP0001440_abnormal_grooming_behavior0.61994332
150MP0006072_abnormal_retinal_apoptosis0.61648993
151MP0002152_abnormal_brain_morphology0.60822641
152MP0002229_neurodegeneration0.60426997

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal septum (HP:0000419)4.26536709
2Macroorchidism (HP:0000053)3.91191709
3Gaze-evoked nystagmus (HP:0000640)3.52423315
4Protruding tongue (HP:0010808)3.52232594
5Abnormality of the proximal phalanges of the hand (HP:0009834)3.42962520
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.32436624
7Papilledema (HP:0001085)3.32048279
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.28857915
9Clumsiness (HP:0002312)3.25704702
10Dysmetric saccades (HP:0000641)3.21361111
11Hyperventilation (HP:0002883)3.14455746
12Subacute progressive viral hepatitis (HP:0006572)3.07334764
13Visual hallucinations (HP:0002367)2.81990802
14Short 1st metacarpal (HP:0010034)2.78834717
15Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.78834717
16Fibular aplasia (HP:0002990)2.73191159
17Morphological abnormality of the middle ear (HP:0008609)2.72337242
18Pancreatic cysts (HP:0001737)2.58612662
19Long nose (HP:0003189)2.58508687
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.56714228
21Insidious onset (HP:0003587)2.56505555
22Termporal pattern (HP:0011008)2.56505555
23Congenital stationary night blindness (HP:0007642)2.55651058
24Abnormality of the 1st metacarpal (HP:0010009)2.54393169
25Decreased circulating renin level (HP:0003351)2.49154117
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.47831636
27Chorioretinal atrophy (HP:0000533)2.39256411
28Papillary thyroid carcinoma (HP:0002895)2.37969363
29Urinary bladder sphincter dysfunction (HP:0002839)2.33636657
30Heterotopia (HP:0002282)2.33552761
31Short hallux (HP:0010109)2.27786925
32Abnormality of the corticospinal tract (HP:0002492)2.25965380
33Drooling (HP:0002307)2.23058001
34Excessive salivation (HP:0003781)2.23058001
35Aplasia/Hypoplasia of the patella (HP:0006498)2.21746062
36Patellar aplasia (HP:0006443)2.20583041
37Meningioma (HP:0002858)2.20255240
38Abnormality of the fingertips (HP:0001211)2.19363254
39Curly hair (HP:0002212)2.19195176
40Focal seizures (HP:0007359)2.18520923
41Mucopolysacchariduria (HP:0008155)2.18065640
42Urinary glycosaminoglycan excretion (HP:0003541)2.18065640
43Abnormality of the renal cortex (HP:0011035)2.17432639
44Fair hair (HP:0002286)2.17422121
45Febrile seizures (HP:0002373)2.17117008
46Hypoglycemic seizures (HP:0002173)2.16807893
47Genetic anticipation (HP:0003743)2.16652105
48Action tremor (HP:0002345)2.14000906
49Ankyloglossia (HP:0010296)2.13942796
50Hyperglycemia (HP:0003074)2.13682534
51Short 4th metacarpal (HP:0010044)2.13084162
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13084162
53Generalized hypopigmentation of hair (HP:0011358)2.12489016
54Hyperinsulinemic hypoglycemia (HP:0000825)2.12116462
55Hyperkalemia (HP:0002153)2.10320375
56Cutaneous melanoma (HP:0012056)2.09790080
57Short chin (HP:0000331)2.09345009
58Abnormality of polysaccharide metabolism (HP:0011012)2.08450781
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08450781
60Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08450781
61Truncal ataxia (HP:0002078)2.07805155
62Abnormality of oral frenula (HP:0000190)2.05905176
63Urinary urgency (HP:0000012)2.05611449
64Chromsome breakage (HP:0040012)2.05457639
65Viral hepatitis (HP:0006562)2.04089750
66Aplasia/Hypoplasia of the hallux (HP:0008362)2.04066811
67Agitation (HP:0000713)2.03005435
68Hamartoma of the eye (HP:0010568)2.02849924
69Furrowed tongue (HP:0000221)2.02502069
70Enlarged penis (HP:0000040)2.00937396
71Supranuclear gaze palsy (HP:0000605)2.00400118
72Partial agenesis of the corpus callosum (HP:0001338)2.00204187
73Abolished electroretinogram (ERG) (HP:0000550)2.00162372
74Persistence of primary teeth (HP:0006335)1.99974651
75Short phalanx of the thumb (HP:0009660)1.99355698
76Transitional cell carcinoma of the bladder (HP:0006740)1.98840934
77Tubular atrophy (HP:0000092)1.97664311
78Abnormality of endocrine pancreas physiology (HP:0012093)1.96275017
79Abnormality of the pancreatic islet cells (HP:0006476)1.96275017
80Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96251641
81Impaired smooth pursuit (HP:0007772)1.95561857
82Increased cerebral lipofuscin (HP:0011813)1.95246333
83Dysostosis multiplex (HP:0000943)1.94630883
84Synostosis of carpal bones (HP:0005048)1.94536640
85Oligodontia (HP:0000677)1.93023708
86Chronic hepatic failure (HP:0100626)1.92971869
87Asymmetry of the thorax (HP:0001555)1.92823129
88Abnormality of binocular vision (HP:0011514)1.91663840
89Diplopia (HP:0000651)1.91663840
90Increased CSF protein (HP:0002922)1.90321563
91Bladder neoplasm (HP:0009725)1.89644466
92Bladder carcinoma (HP:0002862)1.89644466
93Aplasia/Hypoplasia of the fibula (HP:0006492)1.89473313
94Goiter (HP:0000853)1.89314017
95Hematochezia (HP:0002573)1.89220804
96Abnormality of the fibula (HP:0002991)1.88839957
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86675190
98Abnormality of alanine metabolism (HP:0010916)1.86675190
99Hyperalaninemia (HP:0003348)1.86675190
100Micronodular cirrhosis (HP:0001413)1.86551523
101Volvulus (HP:0002580)1.84510383
102Progressive inability to walk (HP:0002505)1.84157209
103Congenital sensorineural hearing impairment (HP:0008527)1.83655699
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82469537
105Truncal obesity (HP:0001956)1.81573348
106Hyperacusis (HP:0010780)1.81293145
107Stomach cancer (HP:0012126)1.80730163
108Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.80233763
109Severe short stature (HP:0003510)1.80161524
110Insulin-resistant diabetes mellitus (HP:0000831)1.79772482
111Amyotrophic lateral sclerosis (HP:0007354)1.79428260
112Blue irides (HP:0000635)1.79379423
113Abnormality of DNA repair (HP:0003254)1.79170597
114Coarse hair (HP:0002208)1.78874667
115Pancreatic fibrosis (HP:0100732)1.78835987
116Symptomatic seizures (HP:0011145)1.78788901
117Spastic gait (HP:0002064)1.78690312
118Hypsarrhythmia (HP:0002521)1.77889336
119Mutism (HP:0002300)1.77428484
120Inappropriate behavior (HP:0000719)1.76085656
121Aqueductal stenosis (HP:0002410)1.75977170
122True hermaphroditism (HP:0010459)1.75759111
123Concave nail (HP:0001598)1.75673825
124EEG with generalized epileptiform discharges (HP:0011198)1.75652945
125Fatigue (HP:0012378)1.75476855
126Ankle clonus (HP:0011448)1.75346991
127Small hand (HP:0200055)1.74481125
128Intention tremor (HP:0002080)1.73825637
129Nephronophthisis (HP:0000090)1.72940695
130Cerebral aneurysm (HP:0004944)1.72689305
131Bony spicule pigmentary retinopathy (HP:0007737)1.72630273
132Resting tremor (HP:0002322)1.72348017
133Abnormality of ocular smooth pursuit (HP:0000617)1.72191247
134Thyroid carcinoma (HP:0002890)1.72100902
135Abnormality of the renal medulla (HP:0100957)1.71565720
136Attenuation of retinal blood vessels (HP:0007843)1.70862788
137Neoplasm of the adrenal cortex (HP:0100641)1.70736523
138Impaired vibration sensation in the lower limbs (HP:0002166)1.70009015
139Cerebral inclusion bodies (HP:0100314)1.69513781
140Renovascular hypertension (HP:0100817)1.69082247
141Abnormality of the astrocytes (HP:0100707)1.68765986
142Astrocytoma (HP:0009592)1.68765986
143Postural instability (HP:0002172)1.68669097
144Absent speech (HP:0001344)1.66962422
145Cystic liver disease (HP:0006706)1.66322238
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.66012399
147Pendular nystagmus (HP:0012043)1.65527126
148Abnormality of the gastric mucosa (HP:0004295)1.65252141
149Sandal gap (HP:0001852)1.65136853
150Epileptiform EEG discharges (HP:0011182)1.64075638
151Abnormal pancreas size (HP:0012094)1.64039212
152Conjunctival hamartoma (HP:0100780)1.63265206
153Hypoplastic ischia (HP:0003175)1.62944533
154Progressive cerebellar ataxia (HP:0002073)1.62547176
155Cubitus valgus (HP:0002967)1.62393791
156Deep palmar crease (HP:0006191)1.62137685
157Thoracolumbar scoliosis (HP:0002944)1.61833209
158Hypoplasia of the pons (HP:0012110)1.61348159
159Abnormality of the lower motor neuron (HP:0002366)1.61323485
160Depression (HP:0000716)1.61077086
161Cutaneous finger syndactyly (HP:0010554)1.61052784
162Disinhibition (HP:0000734)1.60571056
163Absence seizures (HP:0002121)1.60506439
164Pigmentary retinal degeneration (HP:0001146)1.60252166
165Pustule (HP:0200039)1.59029647
166Hand muscle atrophy (HP:0009130)1.58613307
167Macroglossia (HP:0000158)1.58609242
168Clonus (HP:0002169)1.57988619
169Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.57977388
170Lip pit (HP:0100267)1.57479465
171Focal motor seizures (HP:0011153)1.57152888
172Menstrual irregularities (HP:0000858)1.56773566
173Retinal atrophy (HP:0001105)1.56522028
174Aneurysm (HP:0002617)1.56491717
175Open mouth (HP:0000194)1.55698706
176Narrow palate (HP:0000189)1.54772749
177Neoplasm of the heart (HP:0100544)1.54334890
178Pancreatic islet-cell hyperplasia (HP:0004510)1.53979195
179Tetraplegia (HP:0002445)1.53469266
180Elfin facies (HP:0004428)1.51960845
181Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.51874908
182Degeneration of the lateral corticospinal tracts (HP:0002314)1.51164850
183Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.51164850
184Abnormal delayed hypersensitivity skin test (HP:0002963)1.50818742
185Hemiplegia (HP:0002301)1.50501238
186Thin bony cortex (HP:0002753)1.49617183
187Exotropia (HP:0000577)1.48970607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.54948973
2MAP3K92.94440818
3MAP3K22.67155398
4ACVR1B2.60530791
5MARK12.46398430
6SCYL22.44342189
7TAOK32.37761174
8INSRR2.24953179
9PIK3CA2.02007286
10NTRK31.93521992
11KSR21.90061232
12MAP3K41.80796198
13CAMK1G1.77965495
14TRIB31.75204206
15LATS11.73924518
16FGFR21.70018332
17RET1.69075641
18BMPR1B1.65210065
19CAMK1D1.64674909
20TRPM71.64476850
21STK391.64294587
22PRKD31.62794198
23HIPK21.61359486
24CAMKK11.58234263
25FGFR31.57349709
26MAPKAPK31.53132230
27EPHA31.51018860
28RPS6KB21.50230752
29TYRO31.47930676
30PTK61.46477176
31CDK121.41500959
32ALK1.38182261
33WNK41.37938222
34RIPK11.37800385
35JAK11.36757996
36NTRK11.36180564
37ICK1.35199439
38CAMKK21.34533926
39SGK31.30339400
40PDGFRB1.29063725
41RIPK41.28811455
42PKN21.28640742
43NTRK21.28302829
44GRK11.24463395
45PDGFRA1.24139419
46PAK61.19790198
47PRKCH1.19150254
48TLK11.13427892
49CASK1.13033749
50EEF2K1.10170083
51CSNK1G21.09987869
52PAK31.08051842
53ERBB31.07117450
54CSNK1A1L1.06814400
55MAPK111.03310406
56SGK21.02409406
57FGFR41.01130766
58MAP3K71.01027489
59JAK21.00425847
60DAPK20.99844155
61SIK20.99797654
62EPHA40.98923056
63ITK0.98497179
64MELK0.98496158
65MAP3K130.98125259
66KSR10.97007548
67RPS6KB10.96155736
68PASK0.96131193
69EPHA20.95092918
70MAP3K100.93728402
71ADRBK20.89074280
72TAF10.88718002
73NEK60.87301522
74STK110.86845191
75LMTK20.83516460
76CDK50.83129045
77PRKAA20.81635957
78OXSR10.81548011
79NUAK10.80866145
80MAP3K10.80688100
81MET0.80566675
82CDK60.80265031
83WNK10.78422234
84SGK4940.77789534
85SGK2230.77789534
86PTK20.76617667
87MAP2K10.76024723
88PDK10.75728768
89RPS6KA60.74715389
90SIK10.74635021
91JAK30.72859367
92MAPK150.71890689
93MINK10.71318317
94PRKD20.70442089
95FER0.68954208
96MAPK130.68755638
97MST1R0.67235414
98MTOR0.65561206
99TAOK10.64395537
100STK38L0.63693017
101MAP2K20.62153145
102AKT30.61986167
103STK380.61720351
104EPHB10.61546531
105CDC42BPA0.61349210
106PDPK10.60268671
107PRKCZ0.60101703
108RAF10.60016554
109BTK0.59989184
110MAP3K140.59778852
111MAP2K40.59536437
112SGK10.59510691
113DYRK1B0.56699055
114ERN10.54333090
115PRKAA10.53480727
116ADRBK10.53471810
117CSNK1G10.51145285
118CSNK1G30.51084871
119YES10.50832936
120MAPK100.48667532
121UHMK10.48431861
122MARK20.47974484
123MAP2K60.47558367
124HCK0.47558061
125BRD40.46087002
126TXK0.46043448
127FES0.45786929
128NEK90.45678124
129CHUK0.45242565
130MAPKAPK50.42716220
131RPS6KA20.42588731
132TEC0.42588210
133BLK0.41763018
134RPS6KA30.41504746
135IKBKB0.40540244
136GRK60.40367279
137EGFR0.40057161
138FYN0.39540524
139RPS6KL10.38605001
140RPS6KC10.38605001
141MAPK80.38352976
142ERBB20.38176610
143BMPR20.37598329
144LCK0.37115831
145CDK90.36065206
146GSK3A0.35685771
147CSK0.35152066

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.39236163
2Type II diabetes mellitus_Homo sapiens_hsa049302.07878402
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79796422
4ABC transporters_Homo sapiens_hsa020101.76598516
5Insulin secretion_Homo sapiens_hsa049111.66474338
6Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62910296
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59887536
8Nitrogen metabolism_Homo sapiens_hsa009101.59667613
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56002897
10Selenocompound metabolism_Homo sapiens_hsa004501.52070487
11Long-term potentiation_Homo sapiens_hsa047201.49823490
12mTOR signaling pathway_Homo sapiens_hsa041501.47943841
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.41952776
14Olfactory transduction_Homo sapiens_hsa047401.41853586
15Dorso-ventral axis formation_Homo sapiens_hsa043201.37371447
16Synaptic vesicle cycle_Homo sapiens_hsa047211.35449280
17Endometrial cancer_Homo sapiens_hsa052131.32472929
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31900718
19Fatty acid biosynthesis_Homo sapiens_hsa000611.31608566
20Estrogen signaling pathway_Homo sapiens_hsa049151.28003916
21Cholinergic synapse_Homo sapiens_hsa047251.27009405
22Prolactin signaling pathway_Homo sapiens_hsa049171.23155987
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.23000067
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22848972
25GABAergic synapse_Homo sapiens_hsa047271.22818805
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22459526
27Glycerolipid metabolism_Homo sapiens_hsa005611.22009872
28Glioma_Homo sapiens_hsa052141.21075558
29Dopaminergic synapse_Homo sapiens_hsa047281.20844785
30Chronic myeloid leukemia_Homo sapiens_hsa052201.20518463
31Cocaine addiction_Homo sapiens_hsa050301.15957995
32Gastric acid secretion_Homo sapiens_hsa049711.15153627
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.13430877
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12242380
35Phototransduction_Homo sapiens_hsa047441.12203833
36Amphetamine addiction_Homo sapiens_hsa050311.12192377
37Circadian entrainment_Homo sapiens_hsa047131.12148850
38Non-small cell lung cancer_Homo sapiens_hsa052231.10691461
39Sulfur metabolism_Homo sapiens_hsa009201.05944922
40Insulin resistance_Homo sapiens_hsa049311.04849716
41ErbB signaling pathway_Homo sapiens_hsa040121.02988540
42Pancreatic cancer_Homo sapiens_hsa052121.02827022
43Morphine addiction_Homo sapiens_hsa050321.02481060
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02170506
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01750962
46Renin secretion_Homo sapiens_hsa049241.01096066
47Salivary secretion_Homo sapiens_hsa049701.00324939
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99782027
49Renal cell carcinoma_Homo sapiens_hsa052110.99366438
50Melanoma_Homo sapiens_hsa052180.99261306
51Glutamatergic synapse_Homo sapiens_hsa047240.98194247
52T cell receptor signaling pathway_Homo sapiens_hsa046600.96483414
53B cell receptor signaling pathway_Homo sapiens_hsa046620.96391657
54GnRH signaling pathway_Homo sapiens_hsa049120.95911433
55Thyroid hormone synthesis_Homo sapiens_hsa049180.95843105
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95788846
57Tryptophan metabolism_Homo sapiens_hsa003800.95749954
58Inositol phosphate metabolism_Homo sapiens_hsa005620.95701036
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95684754
60Colorectal cancer_Homo sapiens_hsa052100.94607471
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93885155
62Pancreatic secretion_Homo sapiens_hsa049720.91168939
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90099700
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87575630
65Osteoclast differentiation_Homo sapiens_hsa043800.86447615
66Type I diabetes mellitus_Homo sapiens_hsa049400.86396510
67Ether lipid metabolism_Homo sapiens_hsa005650.85593336
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85592485
69Calcium signaling pathway_Homo sapiens_hsa040200.83960137
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83791188
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82414611
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81832155
73Lysine degradation_Homo sapiens_hsa003100.79679568
74VEGF signaling pathway_Homo sapiens_hsa043700.79078137
75Long-term depression_Homo sapiens_hsa047300.78933145
76cAMP signaling pathway_Homo sapiens_hsa040240.78863480
77Choline metabolism in cancer_Homo sapiens_hsa052310.78140113
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77215604
79MicroRNAs in cancer_Homo sapiens_hsa052060.76858445
80Chemokine signaling pathway_Homo sapiens_hsa040620.76248492
81Ovarian steroidogenesis_Homo sapiens_hsa049130.75591015
82FoxO signaling pathway_Homo sapiens_hsa040680.74602610
83Gap junction_Homo sapiens_hsa045400.74208787
84Insulin signaling pathway_Homo sapiens_hsa049100.73989494
85Histidine metabolism_Homo sapiens_hsa003400.73337137
86Nicotine addiction_Homo sapiens_hsa050330.72628563
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.72293619
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72217855
89Vibrio cholerae infection_Homo sapiens_hsa051100.72076228
90Hepatitis C_Homo sapiens_hsa051600.71783729
91Linoleic acid metabolism_Homo sapiens_hsa005910.71783130
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71760702
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70777639
94Oxytocin signaling pathway_Homo sapiens_hsa049210.70743048
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70538755
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70099158
97Prostate cancer_Homo sapiens_hsa052150.69358583
98Taste transduction_Homo sapiens_hsa047420.68885099
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.68823194
100Bile secretion_Homo sapiens_hsa049760.68821508
101MAPK signaling pathway_Homo sapiens_hsa040100.68674189
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68248091
103Axon guidance_Homo sapiens_hsa043600.67473155
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67448419
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67426835
106Lysosome_Homo sapiens_hsa041420.67063471
107Circadian rhythm_Homo sapiens_hsa047100.66037641
108TGF-beta signaling pathway_Homo sapiens_hsa043500.65569993
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.65366605
110Toxoplasmosis_Homo sapiens_hsa051450.64405560
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64139081
112Melanogenesis_Homo sapiens_hsa049160.63672797
113Endocytosis_Homo sapiens_hsa041440.63184187
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63089401
115Platelet activation_Homo sapiens_hsa046110.61915173
116Acute myeloid leukemia_Homo sapiens_hsa052210.61842985
117Glucagon signaling pathway_Homo sapiens_hsa049220.61689799
118Retinol metabolism_Homo sapiens_hsa008300.60731173
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60003287
120Ras signaling pathway_Homo sapiens_hsa040140.59546836
121Thyroid cancer_Homo sapiens_hsa052160.59342412
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.59142423
123TNF signaling pathway_Homo sapiens_hsa046680.58436702
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.57413584
125N-Glycan biosynthesis_Homo sapiens_hsa005100.57116289
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.57077461
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.55357456
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.55060368
129Prion diseases_Homo sapiens_hsa050200.54930436
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54909590
131Proteoglycans in cancer_Homo sapiens_hsa052050.54673494
132AMPK signaling pathway_Homo sapiens_hsa041520.54033189
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.53548453
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53483403
135Serotonergic synapse_Homo sapiens_hsa047260.52760690

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