AVPR1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1androgen biosynthetic process (GO:0006702)9.73644431
2C21-steroid hormone biosynthetic process (GO:0006700)9.21939309
3L-phenylalanine catabolic process (GO:0006559)7.44359763
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44359763
5L-phenylalanine metabolic process (GO:0006558)7.14711182
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.14711182
7C21-steroid hormone metabolic process (GO:0008207)6.85848234
8aromatic amino acid family catabolic process (GO:0009074)6.68137643
9cellular response to antibiotic (GO:0071236)6.35260466
10progesterone metabolic process (GO:0042448)6.23086000
11positive regulation of hormone biosynthetic process (GO:0046886)6.14630316
12cellular response to epinephrine stimulus (GO:0071872)6.11315000
13indole-containing compound catabolic process (GO:0042436)6.04091770
14indolalkylamine catabolic process (GO:0046218)6.04091770
15tryptophan catabolic process (GO:0006569)6.04091770
16negative regulation of fibrinolysis (GO:0051918)6.02552190
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.96311832
18bile acid biosynthetic process (GO:0006699)5.92191162
19kynurenine metabolic process (GO:0070189)5.89872247
20glyoxylate metabolic process (GO:0046487)5.77894363
21regulation of fibrinolysis (GO:0051917)5.72224400
22hormone biosynthetic process (GO:0042446)5.71164275
23tryptophan metabolic process (GO:0006568)5.66985803
24peptidyl-glutamic acid carboxylation (GO:0017187)5.64168717
25protein carboxylation (GO:0018214)5.64168717
26regulation of protein activation cascade (GO:2000257)5.58904246
27complement activation, alternative pathway (GO:0006957)5.55337924
28urea metabolic process (GO:0019627)5.50705195
29urea cycle (GO:0000050)5.50705195
30cysteine metabolic process (GO:0006534)5.48105486
31sulfur amino acid catabolic process (GO:0000098)5.46256180
32cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.42052109
33high-density lipoprotein particle remodeling (GO:0034375)5.34276623
34alpha-linolenic acid metabolic process (GO:0036109)5.26948663
35regulation of complement activation (GO:0030449)5.23940849
36response to epinephrine (GO:0071871)5.14399940
37nitrogen cycle metabolic process (GO:0071941)5.06572516
38cellular response to gonadotropin stimulus (GO:0071371)5.06333216
39androgen metabolic process (GO:0008209)5.01109909
40serine family amino acid catabolic process (GO:0009071)4.99688078
41bile acid metabolic process (GO:0008206)4.97244638
42homocysteine metabolic process (GO:0050667)4.95062634
43cellular response to toxic substance (GO:0097237)4.93686645
44regulation of apoptotic cell clearance (GO:2000425)4.90668302
45aromatic amino acid family metabolic process (GO:0009072)4.84978754
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.79722241
47response to insecticide (GO:0017085)4.75968461
48positive regulation of hormone metabolic process (GO:0032352)4.73319434
49tyrosine metabolic process (GO:0006570)4.71034089
50cellular response to growth hormone stimulus (GO:0071378)4.64841019
51response to methylmercury (GO:0051597)4.64233663
52ketone biosynthetic process (GO:0042181)4.63425498
53reverse cholesterol transport (GO:0043691)4.61803119
54estrogen biosynthetic process (GO:0006703)4.58090368
55regulation of triglyceride catabolic process (GO:0010896)4.57998109
56lysine metabolic process (GO:0006553)4.57307930
57lysine catabolic process (GO:0006554)4.57307930
58regulation of cholesterol esterification (GO:0010872)4.56072101
59plasma lipoprotein particle remodeling (GO:0034369)4.53249504
60protein-lipid complex remodeling (GO:0034368)4.53249504
61macromolecular complex remodeling (GO:0034367)4.53249504
62response to follicle-stimulating hormone (GO:0032354)4.51896239
63triglyceride homeostasis (GO:0070328)4.50597561
64acylglycerol homeostasis (GO:0055090)4.50597561
65alpha-amino acid catabolic process (GO:1901606)4.50087293
66amino-acid betaine metabolic process (GO:0006577)4.46585379
67bile acid and bile salt transport (GO:0015721)4.39020184
68cellular ketone body metabolic process (GO:0046950)4.34928908
69coenzyme catabolic process (GO:0009109)4.31733828
70fibrinolysis (GO:0042730)4.28095837
71glycine metabolic process (GO:0006544)4.27523159
72plasma lipoprotein particle clearance (GO:0034381)4.27162377
73indolalkylamine metabolic process (GO:0006586)4.26773224
74exogenous drug catabolic process (GO:0042738)4.26215618
75cellular glucuronidation (GO:0052695)4.26112889
76negative regulation of sterol transport (GO:0032372)4.23615720
77negative regulation of cholesterol transport (GO:0032375)4.23615720
78phospholipid efflux (GO:0033700)4.20247922
79imidazole-containing compound metabolic process (GO:0052803)4.19947154
80glutamate metabolic process (GO:0006536)4.16576069
81cellular amino acid catabolic process (GO:0009063)4.16557478
82amine catabolic process (GO:0009310)4.14534941
83cellular biogenic amine catabolic process (GO:0042402)4.14534941
84serine family amino acid metabolic process (GO:0009069)4.13103609
85aldehyde catabolic process (GO:0046185)4.08828820
86cellular modified amino acid catabolic process (GO:0042219)4.08175383
87benzene-containing compound metabolic process (GO:0042537)4.06907507
88negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.04767157
89serine family amino acid biosynthetic process (GO:0009070)4.03496642
90ethanol oxidation (GO:0006069)3.98755460
91cholesterol efflux (GO:0033344)3.97672753
92arginine metabolic process (GO:0006525)3.94201838
93dicarboxylic acid biosynthetic process (GO:0043650)3.91278959
94regulation of humoral immune response (GO:0002920)3.87913189
95uronic acid metabolic process (GO:0006063)3.82671275
96glucuronate metabolic process (GO:0019585)3.82671275
97detection of molecule of bacterial origin (GO:0032490)3.82063375
98blood coagulation, intrinsic pathway (GO:0007597)3.81558544
99complement activation, classical pathway (GO:0006958)3.80936084
100low-density lipoprotein particle remodeling (GO:0034374)3.78090506
101complement activation (GO:0006956)3.77991740
102regulation of plasminogen activation (GO:0010755)3.77563913
103plasma lipoprotein particle assembly (GO:0034377)3.77044153
104ketone body metabolic process (GO:1902224)3.75070303
105protein activation cascade (GO:0072376)3.74866821
106opsonization (GO:0008228)3.74681293
107negative regulation of protein activation cascade (GO:2000258)3.72715338
108cofactor catabolic process (GO:0051187)3.71004010
109cytolysis (GO:0019835)3.70414551
110regulation of cholesterol homeostasis (GO:2000188)3.64998157
111positive regulation of steroid biosynthetic process (GO:0010893)3.64951710
112carboxylic acid catabolic process (GO:0046395)3.64131822
113organic acid catabolic process (GO:0016054)3.64131822
114negative regulation of lipase activity (GO:0060192)3.64019019
115Leydig cell differentiation (GO:0033327)3.63990929
116response to leptin (GO:0044321)3.60748561
117acetyl-CoA metabolic process (GO:0006084)3.59807468
118very-low-density lipoprotein particle assembly (GO:0034379)3.58430678
119endothelium development (GO:0003158)3.57972224
120cholesterol homeostasis (GO:0042632)3.57362348
121toxin metabolic process (GO:0009404)3.56763055
122drug catabolic process (GO:0042737)3.56229851
123positive regulation of lipid catabolic process (GO:0050996)3.55910372
124omega-hydroxylase P450 pathway (GO:0097267)3.55096303
125acute-phase response (GO:0006953)3.54170913
126regulation of bile acid biosynthetic process (GO:0070857)3.53317198
127sterol homeostasis (GO:0055092)3.52313119
128short-chain fatty acid metabolic process (GO:0046459)3.51353036
129phospholipid homeostasis (GO:0055091)3.50036492
130positive regulation of triglyceride lipase activity (GO:0061365)3.48732107
131positive regulation of lipoprotein lipase activity (GO:0051006)3.48732107
132cellular response to cadmium ion (GO:0071276)3.44531038
133negative regulation of platelet activation (GO:0010544)3.44329854
134response to gonadotropin (GO:0034698)3.41124749
135epoxygenase P450 pathway (GO:0019373)3.40395014
136positive regulation of steroid metabolic process (GO:0045940)3.38533238
137response to vitamin E (GO:0033197)3.32504976
138regulation of steroid hormone biosynthetic process (GO:0090030)3.22172477
139regulation of lipoprotein metabolic process (GO:0050746)3.17336563
140ovulation (GO:0030728)3.12817005
141cellular hormone metabolic process (GO:0034754)3.12696455
142negative regulation of norepinephrine secretion (GO:0010700)3.09274232
143thrombin receptor signaling pathway (GO:0070493)3.07351052
144* response to corticosterone (GO:0051412)3.06795098
145cellular ketone metabolic process (GO:0042180)3.01120338
146regulation of cholesterol efflux (GO:0010874)2.94171058
147cellular response to dexamethasone stimulus (GO:0071549)2.91437331
148regulation of platelet activation (GO:0010543)2.91355885
149response to growth hormone (GO:0060416)2.90902989
150regulation of macrophage derived foam cell differentiation (GO:0010743)2.82709062
151regulation of transforming growth factor beta2 production (GO:0032909)2.80788114
152cellular response to monoamine stimulus (GO:0071868)2.79199455
153cellular response to catecholamine stimulus (GO:0071870)2.79199455
154negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79143934
155intracellular lipid transport (GO:0032365)2.78705711
156response to dexamethasone (GO:0071548)2.78628311
157low-density lipoprotein particle clearance (GO:0034383)2.77559490
158adrenal gland development (GO:0030325)2.76947107
159estrogen metabolic process (GO:0008210)2.73945635
160negative regulation of blood coagulation (GO:0030195)2.73834674
161negative regulation of hemostasis (GO:1900047)2.73834674
162regulation of acute inflammatory response (GO:0002673)2.71039245
163positive regulation of hemostasis (GO:1900048)2.68602107
164positive regulation of blood coagulation (GO:0030194)2.68602107
165positive regulation of cholesterol efflux (GO:0010875)2.66474938
166positive regulation of cholesterol transport (GO:0032376)2.61710538
167positive regulation of sterol transport (GO:0032373)2.61710538
168response to phenylpropanoid (GO:0080184)2.57101506
169cGMP-mediated signaling (GO:0019934)2.56409062
170glucocorticoid biosynthetic process (GO:0006704)17.6296058
171glucocorticoid metabolic process (GO:0008211)12.5348950

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.04642713
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.87082267
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.64893972
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.23173111
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92378758
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.79438465
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.75382876
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93861099
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67868108
10EZH2_22144423_ChIP-Seq_EOC_Human3.67260600
11GBX2_23144817_ChIP-Seq_PC3_Human2.45184808
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40696146
13SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.27467570
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04817293
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5593110
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.96967917
17* CLOCK_20551151_ChIP-Seq_293T_Human1.95812627
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87195847
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78262911
20SCL_19346495_ChIP-Seq_HPC-7_Human1.70661658
21PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63162164
22GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62698429
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61190067
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.56532222
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55541137
26GATA1_19941826_ChIP-Seq_K562_Human1.51540739
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.51263038
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50577405
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49140793
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47952669
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.44589582
32HTT_18923047_ChIP-ChIP_STHdh_Human1.44183900
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.42060453
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.41267496
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39567026
36TCF4_18268006_ChIP-ChIP_LS174T_Human1.37622539
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33506396
38GATA2_19941826_ChIP-Seq_K562_Human1.31700558
39HNF4A_19822575_ChIP-Seq_HepG2_Human1.31589291
40DROSHA_22980978_ChIP-Seq_HELA_Human1.30664691
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29684610
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29309975
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.28675932
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28626912
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27866854
46AR_21572438_ChIP-Seq_LNCaP_Human1.23253238
47VDR_22108803_ChIP-Seq_LS180_Human1.22292441
48* AR_25329375_ChIP-Seq_VCAP_Human1.20432892
49PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20257703
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11812921
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.10921892
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10531147
53ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09935961
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.09578993
55* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09560172
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07382823
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05971879
58* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05822235
59TCF4_23295773_ChIP-Seq_U87_Human1.05663115
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.04893030
61* LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04634878
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03039664
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.03000518
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02374801
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.01971661
66GATA1_22025678_ChIP-Seq_K562_Human1.01694355
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00551738
68* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00259742
69* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00259742
70* TBL1_22424771_ChIP-Seq_293T_Human0.99612181
71* GF1_26923725_Chip-Seq_HPCs_Mouse0.99067522
72AHR_22903824_ChIP-Seq_MCF-7_Human0.98655553
73STAT3_23295773_ChIP-Seq_U87_Human0.98515089
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97940143
75NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97871144
76SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97831710
77SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97218751
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96730851
79NFE2_27457419_Chip-Seq_LIVER_Mouse0.95796402
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.95513001
81CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95193252
82GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95028174
83* P300_19829295_ChIP-Seq_ESCs_Human0.94142947
84NFYA_21822215_ChIP-Seq_K562_Human0.93812421
85* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93620674
86ESR2_21235772_ChIP-Seq_MCF-7_Human0.92796895
87* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92502850
88WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92103212
89* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91222753
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90991882
91PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90957809
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90882925
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90869849
94* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90293823
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89355140
96* SOX2_21211035_ChIP-Seq_LN229_Gbm0.89326568
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88768599
98* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88180049
99ETV1_20927104_ChIP-Seq_GIST48_Human0.87866077
100* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87114857
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.86502296
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86071371
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86023150
104OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85869843
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82447170
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.82118487
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.81719835
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81516214
109ZNF263_19887448_ChIP-Seq_K562_Human0.80419714
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79552928
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78958864
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77410763
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76808166
114GATA4_25053715_ChIP-Seq_YYC3_Human0.75405111
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73258837
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72981148
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72363200
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71094034
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69245634
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65112331
121FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.64287602
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.63903319
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.63758295
124LXR_22292898_ChIP-Seq_THP-1_Human0.60844220
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60361025
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.58328752
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.57345494
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57209799
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55966614
130SOX2_20726797_ChIP-Seq_SW620_Human0.55960095
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55717821
132EGR1_19032775_ChIP-ChIP_M12_Human0.55423350
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.55110911
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.54892141
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.54493394
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.53920979
137MYC_19915707_ChIP-ChIP_AK7_Human0.51904105
138BCAT_22108803_ChIP-Seq_LS180_Human0.50657207
139NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50511610
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50019627
141CBP_21632823_ChIP-Seq_H3396_Human0.49636637
142CJUN_26792858_Chip-Seq_BT549_Human0.49437188
143* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.49360594
144FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.48744181
145TAF15_26573619_Chip-Seq_HEK293_Human0.48501588
146CEBPB_22108803_ChIP-Seq_LS180_Human0.48460248
147AR_20517297_ChIP-Seq_VCAP_Human0.47590145
148SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47001638
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.46452969
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.46320634
151FOXA1_25552417_ChIP-Seq_VCAP_Human0.46065950
152IRF8_22096565_ChIP-ChIP_GC-B_Human0.45214871
153TP63_17297297_ChIP-ChIP_HaCaT_Human0.44283169
154STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.43811020
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43016075
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.42325315
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.42158296
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.40671722
159CSB_26484114_Chip-Seq_FIBROBLAST_Human0.40340949
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39818918
161* P53_21459846_ChIP-Seq_SAOS-2_Human0.39337873
162STAT1_17558387_ChIP-Seq_HELA_Human0.38692071
163PIAS1_25552417_ChIP-Seq_VCAP_Human0.37516785
164* MYC_27129775_Chip-Seq_CORNEA_Mouse0.36346221
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.35883834
166RACK7_27058665_Chip-Seq_MCF-7_Human0.35656985
167TAF2_19829295_ChIP-Seq_ESCs_Human0.35574333
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.35541450
169GATA3_24758297_ChIP-Seq_MCF-7_Human0.35093977
170TBX20_22328084_ChIP-Seq_HEART_Mouse0.35084481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.94031244
2MP0005360_urolithiasis7.49091642
3MP0008004_abnormal_stomach_pH6.38526171
4MP0005085_abnormal_gallbladder_physiolo6.12627776
5MP0005365_abnormal_bile_salt5.91681322
6MP0008875_abnormal_xenobiotic_pharmacok4.75451488
7MP0003806_abnormal_nucleotide_metabolis4.18422869
8MP0003252_abnormal_bile_duct3.93030495
9MP0002909_abnormal_adrenal_gland3.44639320
10MP0010329_abnormal_lipoprotein_level3.42153502
11MP0003195_calcinosis3.05721988
12MP0009840_abnormal_foam_cell2.97296296
13MP0005083_abnormal_biliary_tract2.88632620
14MP0005332_abnormal_amino_acid2.73572396
15MP0008995_early_reproductive_senescence2.70104953
16MP0001666_abnormal_nutrient_absorption2.41907379
17MP0003705_abnormal_hypodermis_morpholog2.20929580
18MP0003191_abnormal_cellular_cholesterol2.09898976
19MP0004019_abnormal_vitamin_homeostasis2.05337137
20MP0000609_abnormal_liver_physiology2.03889916
21MP0002118_abnormal_lipid_homeostasis1.98474551
22MP0004084_abnormal_cardiac_muscle1.92819821
23MP0004036_abnormal_muscle_relaxation1.89512364
24MP0002138_abnormal_hepatobiliary_system1.85371443
25MP0008438_abnormal_cutaneous_collagen1.81704583
26MP0003868_abnormal_feces_composition1.78315993
27MP0005319_abnormal_enzyme/_coenzyme1.74290165
28MP0001879_abnormal_lymphatic_vessel1.72587921
29MP0000343_altered_response_to1.63102826
30MP0004484_altered_response_of1.61204980
31MP0001984_abnormal_olfaction1.55638408
32MP0001485_abnormal_pinna_reflex1.54477348
33MP0005584_abnormal_enzyme/coenzyme_acti1.52752662
34MP0009697_abnormal_copulation1.51082494
35MP0006138_congestive_heart_failure1.49678334
36MP0003879_abnormal_hair_cell1.47057031
37MP0001765_abnormal_ion_homeostasis1.41768301
38MP0003011_delayed_dark_adaptation1.41482636
39MP0001764_abnormal_homeostasis1.41385323
40MP0002638_abnormal_pupillary_reflex1.36250571
41MP0009780_abnormal_chondrocyte_physiolo1.35567638
42MP0010368_abnormal_lymphatic_system1.30875437
43MP0000465_gastrointestinal_hemorrhage1.29723536
44MP0005377_hearing/vestibular/ear_phenot1.25892192
45MP0003878_abnormal_ear_physiology1.25892192
46MP0005451_abnormal_body_composition1.21492124
47MP0003566_abnormal_cell_adhesion1.20589890
48MP0005646_abnormal_pituitary_gland1.19353320
49MP0009643_abnormal_urine_homeostasis1.19155701
50MP0002127_abnormal_cardiovascular_syste1.19085415
51MP0003186_abnormal_redox_activity1.18901018
52MP0008775_abnormal_heart_ventricle1.17208882
53MP0004510_myositis1.16572370
54MP0009384_cardiac_valve_regurgitation1.15007998
55MP0000598_abnormal_liver_morphology1.12520479
56MP0005647_abnormal_sex_gland1.11403188
57MP0003656_abnormal_erythrocyte_physiolo1.09911641
58MP0003828_pulmonary_edema1.09674787
59MP0009764_decreased_sensitivity_to1.07739447
60MP0005275_abnormal_skin_tensile1.04685660
61MP0002254_reproductive_system_inflammat1.04451970
62MP0000604_amyloidosis1.03856014
63MP0004134_abnormal_chest_morphology1.00638199
64MP0005379_endocrine/exocrine_gland_phen1.00604663
65MP0001851_eye_inflammation0.98695572
66MP0009763_increased_sensitivity_to0.98097762
67MP0000631_abnormal_neuroendocrine_gland0.96983550
68MP0004215_abnormal_myocardial_fiber0.94180399
69MP0002998_abnormal_bone_remodeling0.93049676
70MP0005167_abnormal_blood-brain_barrier0.92566343
71MP0005084_abnormal_gallbladder_morpholo0.92244836
72MP0005636_abnormal_mineral_homeostasis0.86388314
73MP0005375_adipose_tissue_phenotype0.86369652
74MP0009053_abnormal_anal_canal0.85893507
75MP0005220_abnormal_exocrine_pancreas0.85452756
76* MP0009642_abnormal_blood_homeostasis0.80471279
77MP0008469_abnormal_protein_level0.80162248
78MP0001661_extended_life_span0.78506118
79MP0005187_abnormal_penis_morphology0.78161112
80* MP0005620_abnormal_muscle_contractility0.76527621
81MP0005376_homeostasis/metabolism_phenot0.76455360
82MP0005385_cardiovascular_system_phenoty0.76452708
83MP0001544_abnormal_cardiovascular_syste0.76452708
84MP0008961_abnormal_basal_metabolism0.75143461
85MP0005670_abnormal_white_adipose0.74478776
86MP0005408_hypopigmentation0.74413130
87MP0005503_abnormal_tendon_morphology0.73686493
88MP0003279_aneurysm0.72835838
89MP0002971_abnormal_brown_adipose0.71688820
90MP0003724_increased_susceptibility_to0.70099155
91MP0002078_abnormal_glucose_homeostasis0.70014975
92MP0005409_darkened_coat_color0.69397828
93MP0002295_abnormal_pulmonary_circulatio0.69136154
94* MP0002128_abnormal_blood_circulation0.68417683
95MP0002060_abnormal_skin_morphology0.67631204
96MP0005165_increased_susceptibility_to0.67402451
97MP0009765_abnormal_xenobiotic_induced0.65370002
98MP0002876_abnormal_thyroid_physiology0.64064574
99MP0004130_abnormal_muscle_cell0.63556759
100MP0001533_abnormal_skeleton_physiology0.63181332
101MP0005334_abnormal_fat_pad0.62603093
102MP0001756_abnormal_urination0.62455281
103MP0002332_abnormal_exercise_endurance0.62439183
104MP0005023_abnormal_wound_healing0.62244188
105MP0002132_abnormal_respiratory_system0.61741042
106MP0003329_amyloid_beta_deposits0.61579201
107MP0001243_abnormal_dermal_layer0.61333308
108MP0006036_abnormal_mitochondrial_physio0.60934250
109MP0002160_abnormal_reproductive_system0.60560641
110MP0005535_abnormal_body_temperature0.59327121
111MP0005448_abnormal_energy_balance0.55460889
112MP0005395_other_phenotype0.54566180
113MP0003690_abnormal_glial_cell0.54560734
114MP0005266_abnormal_metabolism0.53927269
115MP0002837_dystrophic_cardiac_calcinosis0.53775251
116MP0002168_other_aberrant_phenotype0.53740102
117MP0002928_abnormal_bile_duct0.49948562
118MP0002796_impaired_skin_barrier0.48784841
119MP0005164_abnormal_response_to0.46884801
120MP0004883_abnormal_blood_vessel0.46220437
121MP0002136_abnormal_kidney_physiology0.44808532
122MP0001542_abnormal_bone_strength0.43617181
123* MP0000639_abnormal_adrenal_gland0.43456105
124MP0006035_abnormal_mitochondrial_morpho0.42873582
125MP0003638_abnormal_response/metabolism_0.42721250
126MP0003075_altered_response_to0.42116321
127MP0000249_abnormal_blood_vessel0.41967257
128MP0008874_decreased_physiological_sensi0.41747949
129MP0005248_abnormal_Harderian_gland0.41360985
130MP0001958_emphysema0.39585256
131MP0000579_abnormal_nail_morphology0.39097918
132MP0008873_increased_physiological_sensi0.38974422
133MP0003436_decreased_susceptibility_to0.37802530
134MP0005666_abnormal_adipose_tissue0.37185688
135MP0005464_abnormal_platelet_physiology0.36794987
136* MP0005595_abnormal_vascular_smooth0.36280077
137MP0005166_decreased_susceptibility_to0.36253940
138MP0009115_abnormal_fat_cell0.33695155
139MP0002970_abnormal_white_adipose0.33320966
140MP0003959_abnormal_lean_body0.33049618
141* MP0000230_abnormal_systemic_arterial0.32546136
142MP0001881_abnormal_mammary_gland0.32367796
143* MP0003953_abnormal_hormone_level0.30283121
144MP0004272_abnormal_basement_membrane0.30146876

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)8.50509884
2Deep venous thrombosis (HP:0002625)7.47878288
3Intrahepatic cholestasis (HP:0001406)7.27009760
4Abnormality of aromatic amino acid family metabolism (HP:0004338)7.12457967
5Prolonged partial thromboplastin time (HP:0003645)6.44678974
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.38699290
7Enlarged penis (HP:0000040)6.27428241
8Xanthomatosis (HP:0000991)6.23631184
9Hypobetalipoproteinemia (HP:0003563)6.03261624
10Renal salt wasting (HP:0000127)5.67946860
11Complement deficiency (HP:0004431)5.61757420
12Hyperaldosteronism (HP:0000859)5.44579926
13Hyperlipoproteinemia (HP:0010980)5.36855264
14Prolonged bleeding time (HP:0003010)5.07172725
15Hypoplasia of the uterus (HP:0000013)4.94619398
16Increased mean platelet volume (HP:0011877)4.77257294
17Joint hemorrhage (HP:0005261)4.70516293
18Hypolipoproteinemia (HP:0010981)4.69192124
19Abnormality of the common coagulation pathway (HP:0010990)4.67533832
20Purpura (HP:0000979)4.66457313
21Hyperammonemia (HP:0001987)4.37463309
22Abnormal platelet volume (HP:0011876)4.33017634
23Epidermoid cyst (HP:0200040)4.30969324
24Hyperglycinemia (HP:0002154)4.28699288
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.27178423
26Hypoalphalipoproteinemia (HP:0003233)4.25518364
27Abnormality of complement system (HP:0005339)4.21088384
28Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12944508
29Abnormality of sulfur amino acid metabolism (HP:0004339)4.10487315
30Fat malabsorption (HP:0002630)4.05009438
31Abnormality of methionine metabolism (HP:0010901)4.00887015
32Ketosis (HP:0001946)4.00246587
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97397044
34Epistaxis (HP:0000421)3.96596861
35Abnormality of renin-angiotensin system (HP:0000847)3.95124705
36Abnormality of the intrinsic pathway (HP:0010989)3.91705880
37Hypokalemic alkalosis (HP:0001949)3.80886694
38Abnormality of serine family amino acid metabolism (HP:0010894)3.73092694
39Abnormality of glycine metabolism (HP:0010895)3.73092694
40Hyperglycinuria (HP:0003108)3.65105187
41Hypoglycemic coma (HP:0001325)3.56225227
42Petechiae (HP:0000967)3.54509244
43Aplasia/hypoplasia of the uterus (HP:0008684)3.53573699
44Conjugated hyperbilirubinemia (HP:0002908)3.50137076
45Abnormality of pyrimidine metabolism (HP:0004353)3.46243623
46Male pseudohermaphroditism (HP:0000037)3.38423251
47Hypokalemia (HP:0002900)3.35158404
48Hypercholesterolemia (HP:0003124)3.34120180
49Adrenal overactivity (HP:0002717)3.25296130
50Spontaneous abortion (HP:0005268)3.23473530
51Myocardial infarction (HP:0001658)3.22159120
52Spontaneous hematomas (HP:0007420)3.21448606
53Abnormality of fatty-acid metabolism (HP:0004359)3.14527271
54Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.12723166
55Hyperbilirubinemia (HP:0002904)3.12277946
56Congenital sensorineural hearing impairment (HP:0008527)3.06385544
57Delayed CNS myelination (HP:0002188)3.05354927
58Steatorrhea (HP:0002570)3.02379648
59Skin nodule (HP:0200036)2.99131396
60Ventricular fibrillation (HP:0001663)2.96971741
61Hepatocellular carcinoma (HP:0001402)2.95066206
62Abnormality of serum amino acid levels (HP:0003112)2.92925248
63Abnormality of nucleobase metabolism (HP:0010932)2.88053221
64Mitral stenosis (HP:0001718)2.86290313
65Ketoacidosis (HP:0001993)2.84913610
66Muscle fiber splitting (HP:0003555)2.80706543
67Abnormality of secondary sexual hair (HP:0009888)2.76813675
68Abnormality of the axillary hair (HP:0100134)2.76813675
69Clitoromegaly (HP:0000057)2.76296276
70Systemic lupus erythematosus (HP:0002725)2.76138552
71Bilateral sensorineural hearing impairment (HP:0008619)2.74644786
72Aortic aneurysm (HP:0004942)2.71901989
73Joint swelling (HP:0001386)2.69963802
74Vascular calcification (HP:0004934)2.67793801
75Cardiovascular calcification (HP:0011915)2.66478188
76Hypochromic microcytic anemia (HP:0004840)2.61665147
77Abnormality of purine metabolism (HP:0004352)2.58958020
78Metabolic acidosis (HP:0001942)2.53797609
79Glomerulonephritis (HP:0000099)2.51991010
80Amyloidosis (HP:0011034)2.49027826
81Accelerated skeletal maturation (HP:0005616)2.45749549
82Abnormality of potassium homeostasis (HP:0011042)2.43889408
83Neonatal onset (HP:0003623)2.43368209
84Lethargy (HP:0001254)2.42504549
85Impaired platelet aggregation (HP:0003540)2.39762834
86Abnormal platelet function (HP:0011869)2.39762834
87Mesangial abnormality (HP:0001966)2.38979445
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38046051
89Dicarboxylic aciduria (HP:0003215)2.38046051
90Abnormal gallbladder morphology (HP:0012437)2.37541023
91Spastic diplegia (HP:0001264)2.36403510
92Gout (HP:0001997)2.35919417
93Cholelithiasis (HP:0001081)2.31895386
94Peritonitis (HP:0002586)2.30169169
95Malnutrition (HP:0004395)2.26607787
96Acanthocytosis (HP:0001927)2.25396438
97Persistence of primary teeth (HP:0006335)2.24481903
98Testicular neoplasm (HP:0010788)2.23646176
99Protrusio acetabuli (HP:0003179)2.22947910
100Hypoplasia of the iris (HP:0007676)2.22570356
101Gingival bleeding (HP:0000225)2.21967199
102Cerebral edema (HP:0002181)2.21699053
103Hypoproteinemia (HP:0003075)2.21573297
104Menorrhagia (HP:0000132)2.19073168
105Irritability (HP:0000737)2.18817972
106Recurrent gram-negative bacterial infections (HP:0005420)2.18187060
107Hypoplastic nipples (HP:0002557)2.17749481
108Esophageal varix (HP:0002040)2.16601655
109Abnormal gallbladder physiology (HP:0012438)2.16284252
110Cholecystitis (HP:0001082)2.16284252
111Hypoglycemic seizures (HP:0002173)2.15495380
112Prolonged QT interval (HP:0001657)2.14015218
113Sensorimotor neuropathy (HP:0007141)2.10640956
114Opisthotonus (HP:0002179)2.10417334
115Abnormal cartilage morphology (HP:0002763)2.09976475
116Sex reversal (HP:0012245)2.08446852
117Abnormal sex determination (HP:0012244)2.08446852
118Conjunctival telangiectasia (HP:0000524)2.08398707
119Poikilocytosis (HP:0004447)2.07918856
120Thrombophlebitis (HP:0004418)2.06638951
121Oligomenorrhea (HP:0000876)2.04379637
122Breast hypoplasia (HP:0003187)2.04203809
123Pancreatitis (HP:0001733)2.03078997
124Metaphyseal dysplasia (HP:0100255)2.02206215
125Azoospermia (HP:0000027)2.00317683
126Brushfield spots (HP:0001088)1.99718062
127Hemorrhage of the eye (HP:0011885)1.98029784
128Enlarged kidneys (HP:0000105)1.97504357
129Vomiting (HP:0002013)1.96817458
130Abnormality of the Achilles tendon (HP:0005109)1.95760551
131Rickets (HP:0002748)1.95684148
132Gonadal dysgenesis (HP:0000133)1.95329565
133Abnormality of the gallbladder (HP:0005264)1.94058683
134Keratoconjunctivitis sicca (HP:0001097)1.91510521
135Late onset (HP:0003584)1.91323579
136Abnormality of proline metabolism (HP:0010907)1.89627713
137Hydroxyprolinuria (HP:0003080)1.89627713
138Striae distensae (HP:0001065)1.89399669
139Bruising susceptibility (HP:0000978)1.87505427
140Nephritis (HP:0000123)1.86175662
141Hypophosphatemic rickets (HP:0004912)1.86035540
142Abnormal enzyme/coenzyme activity (HP:0012379)1.86031409
143Round ear (HP:0100830)1.85385676
144Increased connective tissue (HP:0009025)1.85002773
145Duplicated collecting system (HP:0000081)1.84888749
146Generalized aminoaciduria (HP:0002909)1.81748987
147Keratoconjunctivitis (HP:0001096)1.79242132
148Asymmetry of the thorax (HP:0001555)1.78956736
149Abnormality of iron homeostasis (HP:0011031)1.78314196
150Arthropathy (HP:0003040)1.78241658
151Back pain (HP:0003418)1.75276230
152Premature rupture of membranes (HP:0001788)1.75218599
153Alkalosis (HP:0001948)1.75110985
154Syncope (HP:0001279)1.73352954
155Abnormality of transition element cation homeostasis (HP:0011030)1.73172262
156Ectopia lentis (HP:0001083)1.72839538
157Stroke (HP:0001297)1.71664351
158Ureteral duplication (HP:0000073)1.71454140
159Atrioventricular block (HP:0001678)1.70438519
160Wrist flexion contracture (HP:0001239)1.69977125
161Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69881197
162Abnormality of the renal collecting system (HP:0004742)1.61783179
163Pulmonary embolism (HP:0002204)1.61383625
164Abnormality of alanine metabolism (HP:0010916)1.56155366
165Hyperalaninemia (HP:0003348)1.56155366
166Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.56155366
167Abnormal spermatogenesis (HP:0008669)1.55389513
168Decreased central vision (HP:0007663)1.53106182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.62440576
2BCKDK6.25835181
3ERN15.08264093
4FGFR44.65184055
5SIK14.10467539
6ERBB43.07200854
7MST42.62337505
8TAOK32.52412413
9NLK2.33541075
10TRIB32.27692754
11INSRR2.19421352
12PIK3CG2.17292311
13PKN22.12694769
14MAP2K42.07130756
15MST1R2.04313507
16MELK2.02001813
17LATS12.01980786
18LATS21.65813254
19MAPK111.64869130
20FLT31.64727742
21ABL21.63401837
22NEK91.61572469
23EPHA31.55784544
24PTK61.52747918
25TYK21.48810241
26TRPM71.46288276
27OBSCN1.40763173
28FRK1.40238472
29TEC1.37870409
30ADRBK21.33792189
31FGFR21.32804666
32KDR1.30114185
33PIM11.24373506
34BTK1.23688103
35PDGFRA1.16949222
36EPHB11.15443419
37DAPK21.14773164
38ERBB21.14371250
39MAP3K71.09790974
40PDK11.06840985
41FER1.06482308
42STK31.05786214
43MAPKAPK31.04731127
44MET1.03851124
45PHKG11.01524744
46PHKG21.01524744
47MAP3K61.01440399
48PDGFRB1.01362627
49JAK21.00823187
50CSF1R1.00516834
51RIPK40.97352486
52JAK10.96795689
53ADRBK10.96291203
54CAMK1G0.95066814
55EPHB20.92771992
56MAPK40.92159121
57PTK20.91175396
58PRKAA20.90715491
59PAK30.90548968
60WNK30.90318314
61DDR20.89727212
62STK38L0.89531104
63TBK10.88785989
64RIPK10.87395235
65MAP3K30.86636060
66MAPK150.85646473
67MAP3K110.85380654
68SGK20.85224820
69MAP2K30.81607404
70DYRK1B0.80471414
71AKT20.77109080
72PRKCZ0.76904382
73CAMK2G0.75708415
74ITK0.75438374
75MAP2K10.74938703
76FES0.74011781
77MAPK120.73642873
78CDK60.73387081
79GRK50.73304267
80ZAP700.73209826
81MYLK0.71631253
82TIE10.70479521
83TGFBR20.69759968
84GSK3A0.69519937
85GRK10.69366613
86SYK0.68741191
87MAP3K100.68123635
88PNCK0.66150073
89PRKACG0.64584321
90LMTK20.63305854
91FGFR30.63108305
92MAP3K140.62691866
93RET0.60037555
94TLK10.59494679
95PRKACA0.58960966
96PRKG10.58484111
97GRK60.57821027
98HCK0.56997764
99CSK0.53173487
100MAPK30.50630418
101PRKAA10.49766953
102PKN10.49733081
103MTOR0.49649947
104CAMKK20.49593952
105PAK20.49337741
106TTN0.49147045
107MAPK70.48388802
108CAMK10.47403972
109PINK10.47355084
110MARK20.46927239
111MAP3K130.46648690
112PIK3CA0.46169412
113MAP3K50.44633734
114MAP2K20.44429333
115TAOK20.42959797
116SGK10.42474715
117STK240.42209947
118CDC42BPA0.41543910
119IGF1R0.41023336
120PDPK10.40923929
121SGK2230.40891083
122SGK4940.40891083
123CAMK1D0.40209465
124PRKACB0.38996965
125PRKCG0.37068912
126FGFR10.36685607
127ILK0.36495724
128MAPKAPK50.36231111
129PTK2B0.36215708
130BMPR1B0.35205307
131MAP2K60.34905242
132TAOK10.34736441
133BMX0.34063802
134CSNK1G10.33954217
135EGFR0.33920213
136IRAK30.33381424
137PDK30.31424200
138PDK40.31424200
139DAPK30.29868876
140KIT0.29630036
141IRAK10.29422871
142PRKD10.29386217
143SGK30.28944023
144PRKCQ0.27627199
145MAP3K10.27180382
146ABL10.25814677
147NTRK10.25380898
148PRKCH0.23807311
149CSNK1G20.21653552
150CAMK40.20477105

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.60212027
2Nitrogen metabolism_Homo sapiens_hsa009103.61465704
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32469513
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32464809
5Arginine biosynthesis_Homo sapiens_hsa002203.01026085
6Complement and coagulation cascades_Homo sapiens_hsa046102.92601537
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69428766
8Tryptophan metabolism_Homo sapiens_hsa003802.67394814
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63209627
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51860095
11Fatty acid degradation_Homo sapiens_hsa000712.46860512
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35046430
13Aldosterone synthesis and secretion_Homo sapiens_hsa049252.24134820
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20149564
15Butanoate metabolism_Homo sapiens_hsa006502.14935083
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09657904
17Peroxisome_Homo sapiens_hsa041462.06317526
18Chemical carcinogenesis_Homo sapiens_hsa052041.97514664
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.94374884
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92818535
21Propanoate metabolism_Homo sapiens_hsa006401.89747433
22Histidine metabolism_Homo sapiens_hsa003401.86561989
23PPAR signaling pathway_Homo sapiens_hsa033201.85228195
24Platelet activation_Homo sapiens_hsa046111.84236537
25Fatty acid metabolism_Homo sapiens_hsa012121.82506296
26Staphylococcus aureus infection_Homo sapiens_hsa051501.76678444
27Caffeine metabolism_Homo sapiens_hsa002321.74143418
28Retinol metabolism_Homo sapiens_hsa008301.69162664
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68928473
30beta-Alanine metabolism_Homo sapiens_hsa004101.68625787
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.67164503
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65524492
33Phenylalanine metabolism_Homo sapiens_hsa003601.59808834
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59689651
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53236065
36Selenocompound metabolism_Homo sapiens_hsa004501.50836299
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48383466
38Bile secretion_Homo sapiens_hsa049761.48178756
39Tyrosine metabolism_Homo sapiens_hsa003501.46423474
40Fatty acid elongation_Homo sapiens_hsa000621.43063307
41Sulfur metabolism_Homo sapiens_hsa009201.39542275
42Pyruvate metabolism_Homo sapiens_hsa006201.33508451
43Steroid biosynthesis_Homo sapiens_hsa001001.31453956
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.26594840
45Starch and sucrose metabolism_Homo sapiens_hsa005001.26278572
46Folate biosynthesis_Homo sapiens_hsa007901.16506379
47Biosynthesis of amino acids_Homo sapiens_hsa012301.14631310
48Systemic lupus erythematosus_Homo sapiens_hsa053221.12329159
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10896635
50Carbon metabolism_Homo sapiens_hsa012001.09447167
51Fat digestion and absorption_Homo sapiens_hsa049751.08476266
52ABC transporters_Homo sapiens_hsa020101.07645634
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.06943274
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03777763
55* Vascular smooth muscle contraction_Homo sapiens_hsa042701.03224379
56Arginine and proline metabolism_Homo sapiens_hsa003300.97909756
57Sulfur relay system_Homo sapiens_hsa041220.93804831
58Vitamin B6 metabolism_Homo sapiens_hsa007500.91180731
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90482550
60Vitamin digestion and absorption_Homo sapiens_hsa049770.89322994
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.84550666
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83872816
63Serotonergic synapse_Homo sapiens_hsa047260.81602709
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80772500
65Lysine degradation_Homo sapiens_hsa003100.78683487
66Focal adhesion_Homo sapiens_hsa045100.74262259
67Pertussis_Homo sapiens_hsa051330.70586995
68Glutathione metabolism_Homo sapiens_hsa004800.70115788
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67765133
70One carbon pool by folate_Homo sapiens_hsa006700.66016867
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62761951
72Dilated cardiomyopathy_Homo sapiens_hsa054140.58402668
73Pancreatic secretion_Homo sapiens_hsa049720.55641631
74Glycerolipid metabolism_Homo sapiens_hsa005610.55573112
75Gap junction_Homo sapiens_hsa045400.55282084
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53345695
77Choline metabolism in cancer_Homo sapiens_hsa052310.52061842
78Prolactin signaling pathway_Homo sapiens_hsa049170.51213596
79Pentose phosphate pathway_Homo sapiens_hsa000300.50909596
80Prion diseases_Homo sapiens_hsa050200.48683558
81Fatty acid biosynthesis_Homo sapiens_hsa000610.48000893
82Renin secretion_Homo sapiens_hsa049240.47939265
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45934296
84Hematopoietic cell lineage_Homo sapiens_hsa046400.45161216
85Metabolic pathways_Homo sapiens_hsa011000.43430131
86Circadian rhythm_Homo sapiens_hsa047100.42692300
87* Phospholipase D signaling pathway_Homo sapiens_hsa040720.40798036
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33907349
89Gastric acid secretion_Homo sapiens_hsa049710.32870444
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.29960922
91Dorso-ventral axis formation_Homo sapiens_hsa043200.28441142
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27577625
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.26071563
94Circadian entrainment_Homo sapiens_hsa047130.25846609
95* Calcium signaling pathway_Homo sapiens_hsa040200.25122050
96Long-term depression_Homo sapiens_hsa047300.24205560
97Galactose metabolism_Homo sapiens_hsa000520.23908541
98Insulin resistance_Homo sapiens_hsa049310.21991584
99Small cell lung cancer_Homo sapiens_hsa052220.19587409
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19201157
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18507763
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18168981
103Sphingolipid metabolism_Homo sapiens_hsa006000.17675094
104PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17483590
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17398553
106Linoleic acid metabolism_Homo sapiens_hsa005910.13666310
107FoxO signaling pathway_Homo sapiens_hsa040680.13432614
108Fructose and mannose metabolism_Homo sapiens_hsa000510.13278719
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12732249
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11573877
111Salivary secretion_Homo sapiens_hsa049700.11407672
112Glucagon signaling pathway_Homo sapiens_hsa049220.08602086
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.07172717
114AMPK signaling pathway_Homo sapiens_hsa041520.02705890
115Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2254829
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.2244735
117Regulation of autophagy_Homo sapiens_hsa04140-0.2029782
118Hepatitis C_Homo sapiens_hsa05160-0.1772992
119African trypanosomiasis_Homo sapiens_hsa05143-0.1680348
120Renin-angiotensin system_Homo sapiens_hsa04614-0.1568469
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1527262
122Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1524985
123ECM-receptor interaction_Homo sapiens_hsa04512-0.1363601
124Protein digestion and absorption_Homo sapiens_hsa04974-0.1301915
125Malaria_Homo sapiens_hsa05144-0.1146543
126Insulin signaling pathway_Homo sapiens_hsa04910-0.0976356
127Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0976005
128Amoebiasis_Homo sapiens_hsa05146-0.0885662
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0805666
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0766920
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0631394
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0460076
133Bladder cancer_Homo sapiens_hsa05219-0.0208437
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0068556

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