AWAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of odontogenesis of dentin-containing tooth (GO:0042487)8.67473345
2lipopolysaccharide biosynthetic process (GO:0009103)8.16037132
3protein-chromophore linkage (GO:0018298)8.07362401
4DNA methylation involved in gamete generation (GO:0043046)7.80750927
5intermediate filament organization (GO:0045109)7.71029734
6multicellular organismal water homeostasis (GO:0050891)7.25650733
7regulation of meiosis I (GO:0060631)7.19135268
8lipopolysaccharide metabolic process (GO:0008653)7.12228033
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.90696886
10peptide cross-linking (GO:0018149)6.90290529
11regulation of protein glycosylation (GO:0060049)6.84521059
12paraxial mesoderm development (GO:0048339)6.66537592
13sulfate transmembrane transport (GO:1902358)6.63437484
14regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.54695522
15regulation of pigment cell differentiation (GO:0050932)6.52673973
16positive regulation of developmental pigmentation (GO:0048087)6.32768281
17keratinocyte differentiation (GO:0030216)6.24490257
18negative regulation of cell cycle G2/M phase transition (GO:1902750)6.10569665
19water homeostasis (GO:0030104)5.99862563
20positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.73841802
21skin morphogenesis (GO:0043589)5.63702000
22sulfate transport (GO:0008272)5.59704788
23atrioventricular valve morphogenesis (GO:0003181)5.53328239
24wound healing, spreading of epidermal cells (GO:0035313)5.52397849
25bundle of His cell to Purkinje myocyte communication (GO:0086069)5.43907421
26wound healing, spreading of cells (GO:0044319)5.40472661
27SMAD protein complex assembly (GO:0007183)5.36138551
28piRNA metabolic process (GO:0034587)5.34178479
29notochord development (GO:0030903)5.29810971
30L-phenylalanine catabolic process (GO:0006559)5.29586473
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.29586473
32ectoderm development (GO:0007398)5.24335059
33epidermis development (GO:0008544)5.24202995
34intermediate filament cytoskeleton organization (GO:0045104)5.22001117
35regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 5.20173549
36intermediate filament-based process (GO:0045103)5.03822632
37tyrosine metabolic process (GO:0006570)5.02729535
38epidermal cell differentiation (GO:0009913)4.65775742
39negative regulation of stem cell proliferation (GO:2000647)4.56770865
40L-phenylalanine metabolic process (GO:0006558)4.54051386
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.54051386
42heme transport (GO:0015886)4.53870680
43ribonucleoprotein complex disassembly (GO:0032988)4.39925352
44negative regulation of cell fate specification (GO:0009996)4.29499239
45gamma-aminobutyric acid signaling pathway (GO:0007214)4.24192769
46positive regulation of endothelial cell apoptotic process (GO:2000353)4.23356118
47virion attachment to host cell (GO:0019062)4.21751638
48adhesion of symbiont to host cell (GO:0044650)4.21751638
49fatty acid elongation (GO:0030497)4.19914898
50regulation of cardioblast differentiation (GO:0051890)4.18293353
51regulation of transforming growth factor beta2 production (GO:0032909)4.17835232
52nodal signaling pathway (GO:0038092)4.17167298
53mitotic cell cycle arrest (GO:0071850)4.10796363
54positive regulation of meiosis (GO:0045836)4.09173464
55glycerol metabolic process (GO:0006071)4.08102656
56response to mercury ion (GO:0046689)4.05997268
57keratinocyte development (GO:0003334)3.94649660
58regulation of odontogenesis (GO:0042481)3.91915253
59centriole replication (GO:0007099)3.86752386
60positive regulation of meiotic cell cycle (GO:0051446)3.85996008
61regulation of interleukin-5 production (GO:0032674)3.85031525
62serotonin receptor signaling pathway (GO:0007210)3.79805227
63protein retention in ER lumen (GO:0006621)3.79068836
64keratinocyte proliferation (GO:0043616)3.78303933
65germinal center formation (GO:0002467)3.78191010
66regulation of keratinocyte proliferation (GO:0010837)3.75223664
67epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.74253866
68meiotic chromosome segregation (GO:0045132)3.73044867
69alditol metabolic process (GO:0019400)3.66664222
70linoleic acid metabolic process (GO:0043651)3.65920737
71adhesion of symbiont to host (GO:0044406)3.60992423
72cell-substrate junction assembly (GO:0007044)3.59466904
73cellular response to gamma radiation (GO:0071480)3.51281718
74sympathetic nervous system development (GO:0048485)3.50220785
75response to epinephrine (GO:0071871)3.45703688
76vitamin transmembrane transport (GO:0035461)3.45438798
77heart valve formation (GO:0003188)3.45131967
78regulation of ruffle assembly (GO:1900027)3.43943091
79sphingosine metabolic process (GO:0006670)3.42330754
80negative regulation of cell-matrix adhesion (GO:0001953)3.42092879
81regulation of developmental pigmentation (GO:0048070)3.42019862
82regulation of rhodopsin mediated signaling pathway (GO:0022400)3.41509175
83regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.39165692
84organelle disassembly (GO:1903008)3.38142602
85embryonic process involved in female pregnancy (GO:0060136)3.34642577
86flavonoid metabolic process (GO:0009812)3.32286315
87regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.30705707
88positive regulation of SMAD protein import into nucleus (GO:0060391)3.28358443
89regulation of T cell chemotaxis (GO:0010819)3.28199183
90positive regulation of T cell chemotaxis (GO:0010820)3.28199183
91inflammatory response to antigenic stimulus (GO:0002437)3.27927129
92pantothenate metabolic process (GO:0015939)3.26109841
93sphingolipid biosynthetic process (GO:0030148)3.25582013
94cardiac right ventricle morphogenesis (GO:0003215)3.23835075
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.23065443
96tachykinin receptor signaling pathway (GO:0007217)3.23044714
97iron coordination entity transport (GO:1901678)3.20708590
98intracellular lipid transport (GO:0032365)3.20511035
99negative regulation of neural precursor cell proliferation (GO:2000178)3.20272790
100DNA damage induced protein phosphorylation (GO:0006975)3.19543181
101toxin metabolic process (GO:0009404)3.17268312
102eyelid development in camera-type eye (GO:0061029)3.11702547
103plasma membrane repair (GO:0001778)3.11481574
104diol metabolic process (GO:0034311)3.11083107
105membrane lipid biosynthetic process (GO:0046467)3.10097381
106sulfur compound transport (GO:0072348)3.09312388
107rhodopsin mediated signaling pathway (GO:0016056)3.08903570
108sphingoid metabolic process (GO:0046519)3.01169390
109aromatic amino acid family catabolic process (GO:0009074)2.99641470
110polyol biosynthetic process (GO:0046173)2.97945811
111regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.97689024
112long-chain fatty acid biosynthetic process (GO:0042759)2.97052107
113skin development (GO:0043588)2.95067727
114negative regulation of cell fate commitment (GO:0010454)2.93240024
115regulation of nuclear cell cycle DNA replication (GO:0033262)2.88479110
116phosphatidylinositol acyl-chain remodeling (GO:0036149)2.87716517
117early endosome to late endosome transport (GO:0045022)2.87251102
118fibrinolysis (GO:0042730)2.87130126
119lysine catabolic process (GO:0006554)2.82853348
120lysine metabolic process (GO:0006553)2.82853348
121cytoskeletal anchoring at plasma membrane (GO:0007016)2.79911709
122negative regulation of glycoprotein biosynthetic process (GO:0010561)2.79340514
123antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78446796
124antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78446796
125dendritic spine morphogenesis (GO:0060997)2.78315067
126hair follicle morphogenesis (GO:0031069)2.75444588
127peptidyl-threonine dephosphorylation (GO:0035970)2.66329972
128establishment of planar polarity (GO:0001736)2.61728510
129establishment of tissue polarity (GO:0007164)2.61728510
130regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.57577811
131negative regulation of T cell mediated immunity (GO:0002710)2.55485731
132primary alcohol catabolic process (GO:0034310)2.55210309
133hormone catabolic process (GO:0042447)2.51437202
134positive regulation of monocyte chemotaxis (GO:0090026)2.49210006
135molting cycle process (GO:0022404)2.43738779
136hair cycle process (GO:0022405)2.43738779
137regulation of cell fate specification (GO:0042659)2.43065492
138regulation of clathrin-mediated endocytosis (GO:2000369)2.42663659
139epithelium development (GO:0060429)2.42493575
140heart valve morphogenesis (GO:0003179)2.41695569
141negative regulation of keratinocyte proliferation (GO:0010839)2.39530687
142ear development (GO:0043583)2.38295618
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.36485636
144response to zinc ion (GO:0010043)2.35416908
145negative regulation of type 2 immune response (GO:0002829)2.35075765
146phosphatidylserine acyl-chain remodeling (GO:0036150)2.34466401
147oocyte development (GO:0048599)2.32954387
148positive regulation of DNA biosynthetic process (GO:2000573)2.32412159
149antigen processing and presentation of endogenous antigen (GO:0019883)2.32407630
150positive regulation of extracellular matrix organization (GO:1903055)2.32316771
151long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.30793884
152regulation of hair follicle development (GO:0051797)2.29263014
153interferon-gamma secretion (GO:0072643)2.28332862
154endosome organization (GO:0007032)2.27475779
155regulation of hair cycle (GO:0042634)2.25222408
156positive regulation of epidermis development (GO:0045684)2.23793286
157regulation of podosome assembly (GO:0071801)2.23743854
158positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.23388961
159citrulline biosynthetic process (GO:0019240)2.22208832
160cellular response to interferon-alpha (GO:0035457)2.21366382
161ephrin receptor signaling pathway (GO:0048013)2.21129556
162ventricular cardiac muscle cell action potential (GO:0086005)2.20368718
163cellular response to exogenous dsRNA (GO:0071360)2.18122079
164negative regulation of glycoprotein metabolic process (GO:1903019)2.15655018
165regulation of axon extension involved in axon guidance (GO:0048841)2.15557322
166centrosome localization (GO:0051642)2.14864038
167epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14527864
168regulation of somitogenesis (GO:0014807)2.14127800
169hair cycle (GO:0042633)15.3841782
170molting cycle (GO:0042303)15.3841782
171keratinization (GO:0031424)14.9075832
172desmosome organization (GO:0002934)14.8912868
173establishment of skin barrier (GO:0061436)12.4462907
174regulation of water loss via skin (GO:0033561)11.0113225
175hemidesmosome assembly (GO:0031581)10.2231834

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.38446939
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.05545370
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.04013883
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.39535362
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94955435
6P63_26484246_Chip-Seq_KERATINOCYTES_Human2.58799048
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52279112
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.50613478
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43991371
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22028615
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13267801
12TP63_17297297_ChIP-ChIP_HaCaT_Human14.5369203
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99984315
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99984315
15EGR1_19032775_ChIP-ChIP_M12_Human1.95223561
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.91564619
17STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.88324344
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.87138790
19SOX9_24532713_ChIP-Seq_HFSC_Mouse1.77137503
20SOX2_19829295_ChIP-Seq_ESCs_Human1.75718563
21NANOG_19829295_ChIP-Seq_ESCs_Human1.75718563
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74643822
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72631436
24POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.72631436
25ZNF263_19887448_ChIP-Seq_K562_Human1.72535673
26STAT1_20625510_ChIP-Seq_HELA_Human1.69353200
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.67974794
28P300_19829295_ChIP-Seq_ESCs_Human1.67576786
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65526025
30FOXH1_21741376_ChIP-Seq_ESCs_Human1.65198546
31GBX2_23144817_ChIP-Seq_PC3_Human1.63657470
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.63294469
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.62298124
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.48448376
35OCT4_20526341_ChIP-Seq_ESCs_Human1.46152476
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44088727
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.43799446
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43672826
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43647920
40* HOXB7_26014856_ChIP-Seq_BT474_Human1.43125479
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.41615365
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.41469022
43CJUN_26792858_Chip-Seq_BT549_Human1.36483225
44TP63_23658742_ChIP-Seq_EP156T_Human1.34851249
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33572858
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32507572
47ER_23166858_ChIP-Seq_MCF-7_Human1.31700525
48STAT3_18555785_ChIP-Seq_MESCs_Mouse1.31101491
49NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30872425
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30537621
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29390643
52SMAD3_21741376_ChIP-Seq_ESCs_Human1.29239166
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28874825
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.28874825
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.26619273
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26174658
57AR_25329375_ChIP-Seq_VCAP_Human1.26159659
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25101594
59RXR_22108803_ChIP-Seq_LS180_Human1.24855239
60GATA6_21074721_ChIP-Seq_CACO-2_Human1.23786802
61TCF4_23295773_ChIP-Seq_U87_Human1.21244227
62NCOR_22424771_ChIP-Seq_293T_Human1.21213999
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20645280
64EZH2_22144423_ChIP-Seq_EOC_Human1.19708710
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19305603
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18864973
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18680362
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.18627717
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.18131613
70KLF5_25053715_ChIP-Seq_YYC3_Human1.18129968
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.17449419
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17214908
73CTCF_27219007_Chip-Seq_Bcells_Human1.16499263
74SOX2_20726797_ChIP-Seq_SW620_Human1.15888602
75ZNF274_21170338_ChIP-Seq_K562_Hela1.14881340
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.14724877
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14394463
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.12815132
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12507550
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11661053
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.10679697
82JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10448183
83* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09943322
84P53_21459846_ChIP-Seq_SAOS-2_Human1.09751218
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09379756
86* ATF3_27146783_Chip-Seq_COLON_Human1.09310802
87STAT3_23295773_ChIP-Seq_U87_Human1.09116746
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08095365
89AR_19668381_ChIP-Seq_PC3_Human1.07547802
90TP63_22573176_ChIP-Seq_HFKS_Human1.06942914
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06913675
92TP53_16413492_ChIP-PET_HCT116_Human1.05740950
93EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05498754
94NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05048523
95RACK7_27058665_Chip-Seq_MCF-7_Human1.04090957
96AHR_22903824_ChIP-Seq_MCF-7_Human1.03555414
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01709976
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01324669
99ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00962195
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00649519
101MYC_19829295_ChIP-Seq_ESCs_Human1.00361223
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.00340116
103TP53_18474530_ChIP-ChIP_U2OS_Human1.00282245
104AR_21572438_ChIP-Seq_LNCaP_Human1.00281618
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99849606
106CBP_20019798_ChIP-Seq_JUKART_Human0.99849606
107JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98881527
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98841433
109TP53_20018659_ChIP-ChIP_R1E_Mouse0.98481375
110EZH2_27294783_Chip-Seq_ESCs_Mouse0.98184363
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98118037
112CRX_20693478_ChIP-Seq_RETINA_Mouse0.98029849
113TCF4_22108803_ChIP-Seq_LS180_Human0.97970002
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.96917867
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96722493
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96570962
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96494234
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96057174
119SPI1_20517297_ChIP-Seq_HL60_Human0.96016174
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95726867
121CTCF_20526341_ChIP-Seq_ESCs_Human0.94780448
122GATA4_25053715_ChIP-Seq_YYC3_Human0.94652810
123NANOG_20526341_ChIP-Seq_ESCs_Human0.92547918
124P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92037221
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91874283
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.89757758
127SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89218590
128LXR_22292898_ChIP-Seq_THP-1_Human0.88831406
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88056214
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87190840
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.86622466
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85607031
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.85514729
134* ARNT_22903824_ChIP-Seq_MCF-7_Human0.84711121
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84035814
136RNF2_27304074_Chip-Seq_ESCs_Mouse0.83259409
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82072268
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81868405
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81708030
140SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81497950
141TAF2_19829295_ChIP-Seq_ESCs_Human0.79844630
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79473825
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.79166416
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.78615469
145SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78407253
146E2F1_20622854_ChIP-Seq_HELA_Human0.78274726
147BCAT_22108803_ChIP-Seq_LS180_Human0.77702694
148DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76977722
149EZH2_27304074_Chip-Seq_ESCs_Mouse0.76288659
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.76279466
151KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75919490
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.75414925
153SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75346667
154CEBPB_22108803_ChIP-Seq_LS180_Human0.75197260
155SCL_19346495_ChIP-Seq_HPC-7_Human0.74522503
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74220023
157RNF2_18974828_ChIP-Seq_MESCs_Mouse0.72573978
158EZH2_18974828_ChIP-Seq_MESCs_Mouse0.72573978
159JARID2_20064375_ChIP-Seq_MESCs_Mouse0.72539452
160SMAD3_21741376_ChIP-Seq_HESCs_Human0.72145695
161SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.71976602
162HNFA_21074721_ChIP-Seq_CACO-2_Human0.71746008
163IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71681788
164TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71508628
165THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71242523
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.71207217
167MTF2_20144788_ChIP-Seq_MESCs_Mouse0.69916339
168PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69629459
169STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.68729240
170OCT1_27270436_Chip-Seq_PROSTATE_Human0.67363845
171RBPJ_21746931_ChIP-Seq_IB4_Human0.66751834
172ELK3_25401928_ChIP-Seq_HUVEC_Human0.66390182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis8.21533884
2MP0003136_yellow_coat_color7.18136090
3MP0002796_impaired_skin_barrier7.14283353
4MP0005171_absent_coat_pigmentation6.85187801
5MP0000383_abnormal_hair_follicle6.59698714
6MP0000579_abnormal_nail_morphology6.14821802
7MP0010234_abnormal_vibrissa_follicle5.40806651
8MP0010678_abnormal_skin_adnexa5.25210393
9MP0002653_abnormal_ependyma_morphology5.21287342
10MP0005275_abnormal_skin_tensile4.99597246
11MP0005501_abnormal_skin_physiology4.16824373
12MP0004381_abnormal_hair_follicle4.08778035
13MP0003045_fibrosis4.07871625
14MP0003890_abnormal_embryonic-extraembry3.92354897
15MP0003646_muscle_fatigue3.52549078
16MP0002098_abnormal_vibrissa_morphology3.36053190
17MP0001216_abnormal_epidermal_layer3.19167195
18MP0003705_abnormal_hypodermis_morpholog3.01591756
19MP0010771_integument_phenotype2.98950436
20MP0000647_abnormal_sebaceous_gland2.97748753
21MP0003879_abnormal_hair_cell2.80385957
22MP0003453_abnormal_keratinocyte_physiol2.76058174
23MP0002060_abnormal_skin_morphology2.72489650
24MP0000467_abnormal_esophagus_morphology2.71599523
25MP0004947_skin_inflammation2.70317461
26MP0000569_abnormal_digit_pigmentation2.63349139
27MP0002254_reproductive_system_inflammat2.45079050
28MP0000377_abnormal_hair_follicle2.44767606
29MP0000427_abnormal_hair_cycle2.37665609
30MP0005409_darkened_coat_color2.18759563
31MP0002138_abnormal_hepatobiliary_system2.06813287
32MP0000762_abnormal_tongue_morphology1.99718016
33MP0003941_abnormal_skin_development1.87630371
34MP0005670_abnormal_white_adipose1.85556902
35MP0005085_abnormal_gallbladder_physiolo1.80210695
36MP0000749_muscle_degeneration1.70089696
37MP0009931_abnormal_skin_appearance1.62620576
38MP0002168_other_aberrant_phenotype1.56040950
39MP0000367_abnormal_coat/_hair1.54006667
40MP0002234_abnormal_pharynx_morphology1.46734678
41MP0002938_white_spotting1.46265639
42MP0004185_abnormal_adipocyte_glucose1.45223627
43MP0001191_abnormal_skin_condition1.45100116
44MP0003300_gastrointestinal_ulcer1.44655758
45MP0005174_abnormal_tail_pigmentation1.42971192
46MP0003566_abnormal_cell_adhesion1.37958593
47MP0005377_hearing/vestibular/ear_phenot1.33146394
48MP0003878_abnormal_ear_physiology1.33146394
49MP0009379_abnormal_foot_pigmentation1.32065897
50MP0005451_abnormal_body_composition1.31293571
51MP0001243_abnormal_dermal_layer1.31185856
52MP0000015_abnormal_ear_pigmentation1.23992734
53MP0005365_abnormal_bile_salt1.16910095
54MP0002075_abnormal_coat/hair_pigmentati1.16024524
55MP0001188_hyperpigmentation1.14948526
56MP0003191_abnormal_cellular_cholesterol1.14295569
57MP0001851_eye_inflammation1.06439992
58MP0004885_abnormal_endolymph1.06344069
59MP0003724_increased_susceptibility_to1.03001587
60MP0004264_abnormal_extraembryonic_tissu1.00493627
61MP0000465_gastrointestinal_hemorrhage0.98032488
62MP0000627_abnormal_mammary_gland0.97035758
63MP0001186_pigmentation_phenotype0.93877043
64MP0005023_abnormal_wound_healing0.92379988
65MP0004233_abnormal_muscle_weight0.92106018
66MP0003195_calcinosis0.89951225
67MP0003011_delayed_dark_adaptation0.86481133
68MP0002877_abnormal_melanocyte_morpholog0.82718524
69MP0001984_abnormal_olfaction0.81052450
70MP0001661_extended_life_span0.79203307
71MP0002160_abnormal_reproductive_system0.77975980
72MP0005395_other_phenotype0.77850530
73MP0003137_abnormal_impulse_conducting0.76972708
74MP0004782_abnormal_surfactant_physiolog0.75342640
75MP0001340_abnormal_eyelid_morphology0.75232251
76MP0001346_abnormal_lacrimal_gland0.74745693
77MP0003448_altered_tumor_morphology0.71131539
78MP0009278_abnormal_bone_marrow0.66402639
79MP0004043_abnormal_pH_regulation0.66214410
80MP0005647_abnormal_sex_gland0.63337624
81MP0001849_ear_inflammation0.63301239
82MP0002269_muscular_atrophy0.63190531
83MP0003303_peritoneal_inflammation0.59476747
84MP0001324_abnormal_eye_pigmentation0.58867812
85MP0006072_abnormal_retinal_apoptosis0.55306126
86MP0002095_abnormal_skin_pigmentation0.54925044
87MP0009053_abnormal_anal_canal0.54638358
88MP0001784_abnormal_fluid_regulation0.53960018
89MP0008770_decreased_survivor_rate0.53955795
90MP0003828_pulmonary_edema0.53847145
91MP0010352_gastrointestinal_tract_polyps0.53479545
92MP0002971_abnormal_brown_adipose0.52998349
93MP0009384_cardiac_valve_regurgitation0.51757659
94MP0003252_abnormal_bile_duct0.50835435
95MP0002735_abnormal_chemical_nociception0.47679548
96MP0003763_abnormal_thymus_physiology0.47494436
97MP0001853_heart_inflammation0.47348134
98MP0006082_CNS_inflammation0.46549479
99MP0004272_abnormal_basement_membrane0.45024887
100MP0005319_abnormal_enzyme/_coenzyme0.44733918
101MP0000534_abnormal_ureter_morphology0.44259637
102MP0002282_abnormal_trachea_morphology0.44141440
103MP0008438_abnormal_cutaneous_collagen0.43106923
104MP0008569_lethality_at_weaning0.42814359
105MP0003436_decreased_susceptibility_to0.40330201
106MP0006138_congestive_heart_failure0.39685828
107MP0004130_abnormal_muscle_cell0.39378929
108MP0005248_abnormal_Harderian_gland0.38544146
109MP0002111_abnormal_tail_morphology0.38344304
110MP0005666_abnormal_adipose_tissue0.37804295
111MP0005389_reproductive_system_phenotype0.36728167
112MP0005165_increased_susceptibility_to0.35699411
113MP0002277_abnormal_respiratory_mucosa0.35639623
114MP0003950_abnormal_plasma_membrane0.35608408
115MP0002972_abnormal_cardiac_muscle0.35252918
116MP0001501_abnormal_sleep_pattern0.35214992
117MP0002127_abnormal_cardiovascular_syste0.34276140
118MP0004147_increased_porphyrin_level0.33837353
119MP0004019_abnormal_vitamin_homeostasis0.33414125
120MP0010030_abnormal_orbit_morphology0.33365327
121MP0000613_abnormal_salivary_gland0.32907063
122MP0002177_abnormal_outer_ear0.32803270
123MP0002133_abnormal_respiratory_system0.32172474
124MP0005388_respiratory_system_phenotype0.32172474
125MP0009115_abnormal_fat_cell0.31116571
126MP0005535_abnormal_body_temperature0.31032981
127MP0000750_abnormal_muscle_regeneration0.30357305
128MP0002332_abnormal_exercise_endurance0.29675154
129MP0003690_abnormal_glial_cell0.29585844
130MP0005330_cardiomyopathy0.29135107
131MP0002148_abnormal_hypersensitivity_rea0.28510925
132MP0003755_abnormal_palate_morphology0.28369657
133MP0003385_abnormal_body_wall0.27819526
134MP0000751_myopathy0.27539374
135MP0005076_abnormal_cell_differentiation0.25460979
136MP0001486_abnormal_startle_reflex0.25308234
137MP0000858_altered_metastatic_potential0.25297490
138MP0005646_abnormal_pituitary_gland0.24934330
139MP0001177_atelectasis0.24899939
140MP0005375_adipose_tissue_phenotype0.24847596
141MP0009764_decreased_sensitivity_to0.22971418
142MP0005000_abnormal_immune_tolerance0.22351212
143MP0001879_abnormal_lymphatic_vessel0.21499908
144MP0005620_abnormal_muscle_contractility0.21482426
145MP0001533_abnormal_skeleton_physiology0.21450669
146MP0002876_abnormal_thyroid_physiology0.21349439
147MP0006054_spinal_hemorrhage0.20539693
148MP0002272_abnormal_nervous_system0.19793413
149MP0002396_abnormal_hematopoietic_system0.19552497
150MP0005167_abnormal_blood-brain_barrier0.19112400
151MP0008874_decreased_physiological_sensi0.18572778
152MP0005075_abnormal_melanosome_morpholog0.18458367
153MP0006035_abnormal_mitochondrial_morpho0.18092933
154MP0003075_altered_response_to0.17913378
155MP0009840_abnormal_foam_cell0.17860757
156MP0003938_abnormal_ear_development0.17787501
157MP0005551_abnormal_eye_electrophysiolog0.17133876
158MP0003937_abnormal_limbs/digits/tail_de0.15618964
159MP0000026_abnormal_inner_ear0.15085838
160MP0000372_irregular_coat_pigmentation0.13436806
161MP0002229_neurodegeneration0.13342543
162MP0002118_abnormal_lipid_homeostasis0.13111892

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.77786160
2Hypotrichosis (HP:0001006)8.59783470
3Focal motor seizures (HP:0011153)7.98227619
4Thick nail (HP:0001805)7.92128962
5Plantar hyperkeratosis (HP:0007556)7.31317111
6Palmoplantar hyperkeratosis (HP:0000972)7.21586972
7Acanthocytosis (HP:0001927)7.03699251
8Palmar hyperkeratosis (HP:0010765)6.80062381
9Alopecia of scalp (HP:0002293)6.73690789
10Onycholysis (HP:0001806)6.64032162
11Increased IgE level (HP:0003212)6.43404401
12Milia (HP:0001056)6.37089433
13Fragile nails (HP:0001808)6.26711455
14Parakeratosis (HP:0001036)6.01182315
15Woolly hair (HP:0002224)5.89025931
16Pili torti (HP:0003777)5.28391248
17Aplastic anemia (HP:0001915)4.98468220
18Nail dystrophy (HP:0008404)4.94219879
19Follicular hyperkeratosis (HP:0007502)4.90681987
20Conjunctival hamartoma (HP:0100780)4.70768152
21Erythroderma (HP:0001019)4.55417790
22Right ventricular cardiomyopathy (HP:0011663)4.53784609
23Erythema (HP:0010783)4.43370483
24Atrophic scars (HP:0001075)4.37816838
25Abnormal blistering of the skin (HP:0008066)4.35873703
26Oral leukoplakia (HP:0002745)4.09188255
27Proximal amyotrophy (HP:0007126)4.01966679
28Corneal erosion (HP:0200020)4.01477190
29Sparse eyelashes (HP:0000653)3.90361001
30Dialeptic seizures (HP:0011146)3.88142678
31Vertebral arch anomaly (HP:0008438)3.77446749
32Spontaneous hematomas (HP:0007420)3.75372234
33Hematochezia (HP:0002573)3.55656946
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.51300710
35Difficulty walking (HP:0002355)3.45995044
36Abnormal hair laboratory examination (HP:0003328)3.41354603
37Colon cancer (HP:0003003)3.35980147
38Scapular winging (HP:0003691)3.33223307
39Bilateral sensorineural hearing impairment (HP:0008619)3.15134265
40Ridged nail (HP:0001807)3.11472691
41Hypohidrosis (HP:0000966)3.09501035
42Aplasia/Hypoplasia of the uvula (HP:0010293)3.07222122
43Focal seizures (HP:0007359)3.00424618
44Ulnar claw (HP:0001178)3.00390466
45Palmoplantar keratoderma (HP:0000982)2.99893422
46Congenital ichthyosiform erythroderma (HP:0007431)2.93956598
47Poikilocytosis (HP:0004447)2.88046320
48Laryngomalacia (HP:0001601)2.87033308
49Lip pit (HP:0100267)2.85250765
50Ulnar bowing (HP:0003031)2.84121243
51Eczematoid dermatitis (HP:0000976)2.83958551
52Fine hair (HP:0002213)2.76609447
53Esophageal varix (HP:0002040)2.75377019
54Hamartoma of the eye (HP:0010568)2.70804287
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68080661
56Conjunctival telangiectasia (HP:0000524)2.67687944
57Overlapping toe (HP:0001845)2.67241056
58Ventricular tachycardia (HP:0004756)2.66205234
59Gangrene (HP:0100758)2.59297090
60Broad ribs (HP:0000885)2.58495762
61Facial shape deformation (HP:0011334)2.58406055
62Potter facies (HP:0002009)2.58406055
63Acanthosis nigricans (HP:0000956)2.54671663
64Abnormality of hair growth rate (HP:0011363)2.51439653
65Slow-growing hair (HP:0002217)2.51439653
66Pancreatic cysts (HP:0001737)2.50273835
67Radial bowing (HP:0002986)2.44409473
68Corneal dystrophy (HP:0001131)2.43494106
69Blepharitis (HP:0000498)2.43283435
70Advanced eruption of teeth (HP:0006288)2.41351787
71Pruritus (HP:0000989)2.39178965
72Brittle hair (HP:0002299)2.38674121
73Aplasia cutis congenita (HP:0001057)2.37135422
74Dry hair (HP:0011359)2.36929913
75Hyperhidrosis (HP:0000975)2.36354078
76Fatigable weakness (HP:0003473)2.34443864
77Abnormality of the neuromuscular junction (HP:0003398)2.34443864
78Ectropion (HP:0000656)2.31669647
79Ankyloglossia (HP:0010296)2.31553760
80Synostosis of carpal bones (HP:0005048)2.29722600
81Hypoplasia of dental enamel (HP:0006297)2.29447961
82Natal tooth (HP:0000695)2.27263768
83Anonychia (HP:0001798)2.25947645
84Dehydration (HP:0001944)2.25300708
85Absent eyebrow (HP:0002223)2.24055062
86Recurrent corneal erosions (HP:0000495)2.23688677
87Lack of skin elasticity (HP:0100679)2.19826740
88Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.19556330
89Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14938824
90Amelogenesis imperfecta (HP:0000705)2.14564986
91Abnormality of the vocal cords (HP:0008777)2.14552973
92Curly hair (HP:0002212)2.14481546
93Hypoparathyroidism (HP:0000829)2.14013684
94Portal hypertension (HP:0001409)2.13896299
95Skin ulcer (HP:0200042)2.13446461
96Enlarged kidneys (HP:0000105)2.11210798
97Esophageal atresia (HP:0002032)2.10719439
98Peripheral hypomyelination (HP:0007182)2.09493627
99Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07865159
100Absent hair (HP:0002298)2.07583365
101Fragile skin (HP:0001030)2.06188249
102Hypergammaglobulinemia (HP:0010702)2.05685114
103Papilloma (HP:0012740)2.04132965
104Verrucae (HP:0200043)2.04132965
105Abnormality of the renal cortex (HP:0011035)2.03019564
106Petechiae (HP:0000967)2.02218714
107Carious teeth (HP:0000670)2.01215277
108Decreased circulating renin level (HP:0003351)2.01107553
109Visceral angiomatosis (HP:0100761)1.99152531
110Hamartoma (HP:0010566)1.98155518
111Tarsal synostosis (HP:0008368)1.97285943
112IgM deficiency (HP:0002850)1.93389587
113Neonatal death (HP:0003811)1.92633518
114Abnormality of the hepatic vasculature (HP:0006707)1.92613023
115Abnormality of the fingernails (HP:0001231)1.92164856
116Abnormality of the shoulder girdle musculature (HP:0001435)1.89136979
117Autoimmune hemolytic anemia (HP:0001890)1.88118626
118Pendular nystagmus (HP:0012043)1.87458997
119Hemangiomatosis (HP:0007461)1.87268149
120Abnormality of secondary sexual hair (HP:0009888)1.87117682
121Abnormality of the axillary hair (HP:0100134)1.87117682
122Hypoplastic iliac wings (HP:0002866)1.85822826
123Cheilitis (HP:0100825)1.82688155
124Aplasia involving bones of the extremities (HP:0009825)1.81735442
125Aplasia involving bones of the upper limbs (HP:0009823)1.81735442
126Aplasia of the phalanges of the hand (HP:0009802)1.81735442
127Ventricular fibrillation (HP:0001663)1.79177415
128Distal lower limb muscle weakness (HP:0009053)1.79099103
129Hypokalemia (HP:0002900)1.77502421
130Hyporeflexia of lower limbs (HP:0002600)1.76113147
131Synostosis involving bones of the lower limbs (HP:0009138)1.76090811
132Synostosis involving bones of the feet (HP:0009140)1.76090811
133Oligodontia (HP:0000677)1.75806094
134Thickened calvaria (HP:0002684)1.73080878
135Subcapsular cataract (HP:0000523)1.71379958
136Type 1 muscle fiber predominance (HP:0003803)1.69402186
137Severe visual impairment (HP:0001141)1.66256263
138Absent eyelashes (HP:0000561)1.64689623
139Abnormality of macular pigmentation (HP:0008002)1.64323096
140Chronic diarrhea (HP:0002028)1.64191842
141Progressive inability to walk (HP:0002505)1.62556811
142Abnormality of potassium homeostasis (HP:0011042)1.62097773
143Nephritis (HP:0000123)1.62009658
144Large earlobe (HP:0009748)1.61970443
145Premature skin wrinkling (HP:0100678)1.61665899
146Albinism (HP:0001022)1.61533368
147Abnormality of oral frenula (HP:0000190)1.61397817
148Premature loss of primary teeth (HP:0006323)1.60640896
149Recurrent bacterial skin infections (HP:0005406)1.60442381
150Round ear (HP:0100830)1.59897661
151Increased connective tissue (HP:0009025)1.59615836
152Down-sloping shoulders (HP:0200021)1.59109228
153Sudden death (HP:0001699)1.55713428
154Urticaria (HP:0001025)1.55467458
155Neonatal onset (HP:0003623)1.49947575
156Pustule (HP:0200039)1.49215194
157Concave nail (HP:0001598)1.47347721
158Autoamputation (HP:0001218)1.46299141
159Severe Myopia (HP:0011003)1.46215169
160Unilateral renal agenesis (HP:0000122)1.45580170
161Malignant hyperthermia (HP:0002047)1.45067134
162Rectal prolapse (HP:0002035)1.44638167
163Autoimmune thrombocytopenia (HP:0001973)1.43979119
164Hypodontia (HP:0000668)1.43919631
165Trismus (HP:0000211)1.42081497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L7.33714420
2MAP3K14.42428535
3MST1R4.26988048
4MST44.26646724
5EPHA24.25478080
6PRKD33.07302673
7MAPKAPK33.06270698
8FER2.94870826
9MAP2K22.86502474
10TRPM72.70043229
11ZAK2.51704793
12PIK3CG2.47478711
13NLK2.46052087
14ERBB32.43653585
15ACVR1B2.42463259
16MAP3K32.27822713
17STK102.26136598
18TGFBR22.23176802
19STK32.17504637
20NTRK22.06382637
21FRK2.01441269
22LRRK21.98495833
23EPHB21.95257816
24MELK1.88774056
25BLK1.65092678
26FGFR11.64375099
27ERN11.61271306
28EEF2K1.57716989
29BMPR1B1.57110835
30TTN1.50031545
31STK241.48699602
32MAP2K61.37718306
33MAP2K31.30287635
34TGFBR11.29654135
35MAPK151.27057262
36CLK11.25133566
37RPS6KB21.24810605
38ADRBK21.21077584
39OBSCN1.20005201
40RIPK41.17727047
41MET1.16610192
42KSR21.12653527
43FGFR31.12127813
44GRK71.08092481
45NEK21.01232871
46TYK20.94526787
47TAF10.92336536
48IRAK30.92242007
49BMX0.91946204
50CAMK1D0.91329941
51MAP2K10.89286571
52MAP2K40.87625380
53MAP3K110.87271954
54TESK10.85900476
55TRIB30.85357231
56MAP3K70.84452679
57CDK30.83623657
58PBK0.83376674
59FGFR40.81754107
60MAPK90.80827449
61HCK0.79955298
62FGFR20.77890836
63MAPKAPK50.76540236
64PINK10.75969416
65ADRBK10.75764122
66STK110.75590878
67EIF2AK30.74503846
68TIE10.72020291
69MAP3K20.71671005
70TEC0.71381557
71TAOK10.70837794
72CHUK0.67515772
73MAP3K90.67345130
74RIPK10.66882223
75CSNK1A1L0.65111749
76RPS6KA50.59899142
77RPS6KA40.59821768
78EIF2AK20.56510853
79PTK60.55149155
80BCR0.54271640
81PRKD10.54134258
82PLK20.52513971
83MATK0.52400656
84MAPK120.52094955
85LATS20.51601706
86PAK20.51134947
87EPHB10.50961453
88MAPKAPK20.49190945
89IRAK20.47145022
90NEK90.46844812
91PIK3CA0.46701684
92DAPK20.43326276
93TTK0.42223422
94MAP3K80.41998422
95MAPK40.39412716
96SRC0.38500829
97CSNK1D0.38041545
98PRKCE0.37735621
99EGFR0.37694047
100CDK60.37313929
101PRKAA20.37238739
102ALK0.36459401
103DDR20.36018203
104RPS6KA10.35560658
105JAK10.35325087
106RPS6KA20.34015233
107LIMK10.33827243
108TNK20.33524578
109PDPK10.32656156
110ERBB20.32497371
111NME10.32348095
112MOS0.30870038
113STK380.30448443
114LATS10.30065836
115CAMK1G0.29743949
116MAPK30.29728328
117IGF1R0.29287277
118CAMK2A0.28985067
119PDK10.28968840
120INSR0.26817198
121GRK50.25971187
122PIM10.24035491
123SYK0.23827811
124STK390.23364471
125OXSR10.16533284
126PRKCI0.15769201
127MAPK70.15415366
128WNK40.15254364
129TAOK30.13883555
130ABL10.10903883
131PLK10.10105077
132ITK0.09883273
133RET0.09556221
134AKT20.08613304
135JAK20.06320627
136CHEK20.04362802
137MAPK10.03407789
138PRKACA0.02459335
139NEK60.02260219
140NEK10.01355805
141MAP3K60.00871235
142BTK-0.0937135
143PRKCG-0.0922117
144NTRK3-0.0879377
145PRKCB-0.0857141
146GSK3B-0.0827296
147AKT1-0.0765586
148CDK4-0.0719546
149CDK5-0.0668161
150PRKCH-0.0651175
151LMTK2-0.0643345
152MYLK-0.0631788
153IRAK4-0.0614948
154RPS6KB1-0.0564793
155EPHA4-0.0547676
156CSNK1A1-0.0523180
157KIT-0.0480047
158PRKACB-0.0398304
159CAMK2B-0.0286258
160PDGFRA-0.0252933
161TXK-0.0211254
162MAPK8-0.0180213

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004008.13885754
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.33649087
3Dorso-ventral axis formation_Homo sapiens_hsa043203.28695989
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.85781617
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.67311885
6Linoleic acid metabolism_Homo sapiens_hsa005912.49097153
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.48588352
8Vitamin digestion and absorption_Homo sapiens_hsa049772.36306708
9ECM-receptor interaction_Homo sapiens_hsa045122.31020071
10Nicotine addiction_Homo sapiens_hsa050332.23296367
11Sphingolipid metabolism_Homo sapiens_hsa006002.04805972
12Fatty acid elongation_Homo sapiens_hsa000621.99829830
13Ether lipid metabolism_Homo sapiens_hsa005651.84077082
14Amoebiasis_Homo sapiens_hsa051461.83226558
15GnRH signaling pathway_Homo sapiens_hsa049121.81656022
16Taste transduction_Homo sapiens_hsa047421.79952931
17Steroid biosynthesis_Homo sapiens_hsa001001.70350125
18ABC transporters_Homo sapiens_hsa020101.69775216
19N-Glycan biosynthesis_Homo sapiens_hsa005101.67908573
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66179316
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55197477
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48843516
23Proteoglycans in cancer_Homo sapiens_hsa052051.48513209
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.47937203
25Bladder cancer_Homo sapiens_hsa052191.41104224
26Staphylococcus aureus infection_Homo sapiens_hsa051501.40497073
27VEGF signaling pathway_Homo sapiens_hsa043701.39429421
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.37677987
29Morphine addiction_Homo sapiens_hsa050321.36126063
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.32698220
31Phenylalanine metabolism_Homo sapiens_hsa003601.32104990
32AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30345999
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28522615
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25755633
35Osteoclast differentiation_Homo sapiens_hsa043801.25674501
36Histidine metabolism_Homo sapiens_hsa003401.25631158
37Small cell lung cancer_Homo sapiens_hsa052221.24053014
38Arachidonic acid metabolism_Homo sapiens_hsa005901.21566385
39Retinol metabolism_Homo sapiens_hsa008301.20104113
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19307605
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14794622
42Pertussis_Homo sapiens_hsa051331.14237687
43Protein digestion and absorption_Homo sapiens_hsa049741.08573656
44Leishmaniasis_Homo sapiens_hsa051401.07183208
45Glycerolipid metabolism_Homo sapiens_hsa005611.06932536
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06123032
47Tryptophan metabolism_Homo sapiens_hsa003801.06039392
48Toxoplasmosis_Homo sapiens_hsa051451.02916541
49Calcium signaling pathway_Homo sapiens_hsa040201.02869863
50Fat digestion and absorption_Homo sapiens_hsa049751.00452591
51GABAergic synapse_Homo sapiens_hsa047271.00413153
52Adherens junction_Homo sapiens_hsa045201.00380278
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.99382791
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98857604
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97153411
56Ras signaling pathway_Homo sapiens_hsa040140.97089770
57Renin secretion_Homo sapiens_hsa049240.95194293
58Ovarian steroidogenesis_Homo sapiens_hsa049130.94146297
59Viral myocarditis_Homo sapiens_hsa054160.94077615
60beta-Alanine metabolism_Homo sapiens_hsa004100.93406701
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93260806
62Hepatitis C_Homo sapiens_hsa051600.93244096
63Axon guidance_Homo sapiens_hsa043600.92096658
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.91245303
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91153779
66Tight junction_Homo sapiens_hsa045300.90979113
67Notch signaling pathway_Homo sapiens_hsa043300.88842890
68Fatty acid degradation_Homo sapiens_hsa000710.88660424
69Tuberculosis_Homo sapiens_hsa051520.88367310
70Hematopoietic cell lineage_Homo sapiens_hsa046400.88187527
71Focal adhesion_Homo sapiens_hsa045100.86827995
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.86016487
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85649623
74Melanogenesis_Homo sapiens_hsa049160.85418328
75Basal cell carcinoma_Homo sapiens_hsa052170.84435210
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83998177
77Caffeine metabolism_Homo sapiens_hsa002320.83854438
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83091237
79Graft-versus-host disease_Homo sapiens_hsa053320.82959182
80Estrogen signaling pathway_Homo sapiens_hsa049150.82801495
81Platelet activation_Homo sapiens_hsa046110.82124444
82Dilated cardiomyopathy_Homo sapiens_hsa054140.80093564
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79442933
84Complement and coagulation cascades_Homo sapiens_hsa046100.78014069
85Mineral absorption_Homo sapiens_hsa049780.77057630
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76338635
87Sulfur metabolism_Homo sapiens_hsa009200.76272051
88PPAR signaling pathway_Homo sapiens_hsa033200.75890830
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75853653
90Nitrogen metabolism_Homo sapiens_hsa009100.75380924
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74489772
92Malaria_Homo sapiens_hsa051440.73942304
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73696140
94ErbB signaling pathway_Homo sapiens_hsa040120.70934716
95Gastric acid secretion_Homo sapiens_hsa049710.70852237
96Hedgehog signaling pathway_Homo sapiens_hsa043400.69060298
97Rap1 signaling pathway_Homo sapiens_hsa040150.68951286
98Pyruvate metabolism_Homo sapiens_hsa006200.68445888
99Glutamatergic synapse_Homo sapiens_hsa047240.65877170
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65013395
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63278201
102Collecting duct acid secretion_Homo sapiens_hsa049660.62893315
103Butanoate metabolism_Homo sapiens_hsa006500.61491831
104Pancreatic secretion_Homo sapiens_hsa049720.60968216
105One carbon pool by folate_Homo sapiens_hsa006700.60158475
106Thyroid cancer_Homo sapiens_hsa052160.60070702
107Fatty acid metabolism_Homo sapiens_hsa012120.59369708
108Endocytosis_Homo sapiens_hsa041440.58412206
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.57281460
110Phototransduction_Homo sapiens_hsa047440.57132177
111Bile secretion_Homo sapiens_hsa049760.55682229
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55058063
113Amphetamine addiction_Homo sapiens_hsa050310.54737244
114MicroRNAs in cancer_Homo sapiens_hsa052060.53846775
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53781288
116Hippo signaling pathway_Homo sapiens_hsa043900.53482104
117Long-term depression_Homo sapiens_hsa047300.52639815
118Chemical carcinogenesis_Homo sapiens_hsa052040.52062932
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.51883252
120Acute myeloid leukemia_Homo sapiens_hsa052210.51628832
121Phagosome_Homo sapiens_hsa041450.51122392
122TNF signaling pathway_Homo sapiens_hsa046680.50645119
123Antigen processing and presentation_Homo sapiens_hsa046120.50350245
124Cocaine addiction_Homo sapiens_hsa050300.50281314
125Salivary secretion_Homo sapiens_hsa049700.49516029
126TGF-beta signaling pathway_Homo sapiens_hsa043500.48295570
127cAMP signaling pathway_Homo sapiens_hsa040240.47542040
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46749781
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.45703747
130Tyrosine metabolism_Homo sapiens_hsa003500.45337127
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43622295
132Salmonella infection_Homo sapiens_hsa051320.43340102
133Selenocompound metabolism_Homo sapiens_hsa004500.43301960
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41613404
135Prolactin signaling pathway_Homo sapiens_hsa049170.41380790
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40842950
137HTLV-I infection_Homo sapiens_hsa051660.40670804
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.39619932
139Insulin resistance_Homo sapiens_hsa049310.38918721
140Serotonergic synapse_Homo sapiens_hsa047260.38915822
141MAPK signaling pathway_Homo sapiens_hsa040100.38901723
142Lysine degradation_Homo sapiens_hsa003100.38659967
143Olfactory transduction_Homo sapiens_hsa047400.38644104
144Colorectal cancer_Homo sapiens_hsa052100.38447820
145Fatty acid biosynthesis_Homo sapiens_hsa000610.38385507
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37484724
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36628622
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30318435
149Pancreatic cancer_Homo sapiens_hsa052120.26929652
150Circadian entrainment_Homo sapiens_hsa047130.25536867
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.23827496
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22454174
153Oocyte meiosis_Homo sapiens_hsa041140.21459342
154Arginine and proline metabolism_Homo sapiens_hsa003300.20737340
155Long-term potentiation_Homo sapiens_hsa047200.19825936
156Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19168310
157Basal transcription factors_Homo sapiens_hsa030220.16876601
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16851939
159Peroxisome_Homo sapiens_hsa041460.14619992
160Glycerophospholipid metabolism_Homo sapiens_hsa005640.13877383
161Lysosome_Homo sapiens_hsa041420.12827831

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