AXIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.09704668
2protein localization to kinetochore (GO:0034501)4.23275299
3DNA unwinding involved in DNA replication (GO:0006268)4.10419461
4folic acid-containing compound biosynthetic process (GO:0009396)4.08712278
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01849659
6negative regulation of cell killing (GO:0031342)4.01849659
7nuclear pore complex assembly (GO:0051292)3.94126683
8nuclear pore organization (GO:0006999)3.88015873
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86131013
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.86131013
11modulation by symbiont of host immune response (GO:0052553)3.86131013
12positive regulation by symbiont of host defense response (GO:0052509)3.86131013
13modulation by symbiont of host defense response (GO:0052031)3.86131013
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86131013
15response to peptidoglycan (GO:0032494)3.79363181
16heterochromatin organization (GO:0070828)3.78860281
17regulation of RNA export from nucleus (GO:0046831)3.78316804
18protein localization to chromosome, centromeric region (GO:0071459)3.54560313
19mannose metabolic process (GO:0006013)3.49166596
20mitotic nuclear envelope disassembly (GO:0007077)3.48216979
21pre-miRNA processing (GO:0031054)3.46472755
22negative regulation of histone methylation (GO:0031061)3.45043011
23regulation of translational fidelity (GO:0006450)3.44065414
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43965937
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.39757409
26response to muramyl dipeptide (GO:0032495)3.35569135
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33528101
28nuclear envelope disassembly (GO:0051081)3.27317729
29membrane disassembly (GO:0030397)3.27317729
30DNA duplex unwinding (GO:0032508)3.25893531
31mitotic chromosome condensation (GO:0007076)3.23992233
32chromatin assembly (GO:0031497)3.22186374
33leukocyte aggregation (GO:0070486)3.21113691
34mRNA stabilization (GO:0048255)3.21092737
35RNA stabilization (GO:0043489)3.21092737
36DNA geometric change (GO:0032392)3.20634688
37response to laminar fluid shear stress (GO:0034616)3.19912776
38detection of bacterium (GO:0016045)3.18839706
39detection of other organism (GO:0098543)3.16748049
40regulation of nucleobase-containing compound transport (GO:0032239)3.16433569
41neutrophil activation involved in immune response (GO:0002283)3.15380083
42positive thymic T cell selection (GO:0045059)3.14918529
43mitotic sister chromatid cohesion (GO:0007064)3.13680618
44IMP biosynthetic process (GO:0006188)3.11091049
45protein localization to endosome (GO:0036010)3.09259610
46regulation of histone H3-K9 methylation (GO:0051570)3.08121900
47positive regulation of histone deacetylation (GO:0031065)3.07965519
483-UTR-mediated mRNA stabilization (GO:0070935)3.06191116
49macrophage activation involved in immune response (GO:0002281)3.05450908
50apoptotic process involved in morphogenesis (GO:0060561)3.04251670
51regulation of gamma-delta T cell differentiation (GO:0045586)3.00676799
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00343748
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00343748
54embryonic process involved in female pregnancy (GO:0060136)2.99085048
55modulation by symbiont of host cellular process (GO:0044068)2.96463040
56dosage compensation (GO:0007549)2.95392946
57modulation by virus of host process (GO:0019054)2.95027857
58formation of translation preinitiation complex (GO:0001731)2.94434420
59protein localization to chromosome (GO:0034502)2.93334511
60glucocorticoid receptor signaling pathway (GO:0042921)2.88541779
61cellular extravasation (GO:0045123)2.88347312
62pore complex assembly (GO:0046931)2.87319934
63nuclear envelope organization (GO:0006998)2.86908378
64histone H3-K36 demethylation (GO:0070544)2.86791752
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86663820
66regulation of spindle organization (GO:0090224)2.85614445
67lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82339823
68IMP metabolic process (GO:0046040)2.79929111
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.79681176
70regulation of chromatin binding (GO:0035561)2.79213560
71NIK/NF-kappaB signaling (GO:0038061)2.78809086
72regulation of hippo signaling (GO:0035330)2.78334985
73positive regulation of gamma-delta T cell activation (GO:0046645)2.76631718
74T cell selection (GO:0045058)2.75867008
75negative regulation of phagocytosis (GO:0050765)2.75656945
76positive regulation of chromosome segregation (GO:0051984)2.75319444
77regulation of translational termination (GO:0006449)2.74972709
78regulation of leukocyte degranulation (GO:0043300)2.74174046
79histone H2A monoubiquitination (GO:0035518)2.72420070
80maternal placenta development (GO:0001893)2.72066953
81sister chromatid segregation (GO:0000819)2.71539661
82regulation of histone H3-K27 methylation (GO:0061085)2.70443359
83trophectodermal cell differentiation (GO:0001829)2.70073126
84regulation of posttranscriptional gene silencing (GO:0060147)2.69992476
85regulation of gene silencing by miRNA (GO:0060964)2.69992476
86regulation of gene silencing by RNA (GO:0060966)2.69992476
87pinocytosis (GO:0006907)2.69530178
88regulation of sister chromatid cohesion (GO:0007063)2.68338427
89DNA replication-dependent nucleosome organization (GO:0034723)2.68267680
90DNA replication-dependent nucleosome assembly (GO:0006335)2.68267680
91epithelial cell differentiation involved in prostate gland development (GO:0060742)2.67802739
92maturation of SSU-rRNA (GO:0030490)2.67273857
93translesion synthesis (GO:0019985)2.64955110
94germinal center formation (GO:0002467)2.64752804
95regulation of T-helper 2 cell differentiation (GO:0045628)2.64588072
96antigen processing and presentation of endogenous antigen (GO:0019883)2.64117949
97regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64076937
98mitotic G1 DNA damage checkpoint (GO:0031571)2.63442175
99regulation of early endosome to late endosome transport (GO:2000641)2.63029388
100negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.61996165
101regulation of mammary gland epithelial cell proliferation (GO:0033599)2.61923696
102mitotic sister chromatid segregation (GO:0000070)2.61009145
103antigen processing and presentation via MHC class Ib (GO:0002475)2.60567968
104positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59980951
105activation of Rac GTPase activity (GO:0032863)2.59669212
106regulation of mRNA stability (GO:0043488)2.58917487
107regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58636336
108peptidyl-lysine dimethylation (GO:0018027)2.58470578
109detection of external biotic stimulus (GO:0098581)2.57789641
110response to UV-C (GO:0010225)2.56924410
111negative regulation of interleukin-12 production (GO:0032695)2.56301580
112negative regulation of RNA splicing (GO:0033119)2.56189716
113regulation of gamma-delta T cell activation (GO:0046643)2.54398678
114regulation of mitotic spindle organization (GO:0060236)2.53354356
115gene silencing by RNA (GO:0031047)2.51930462
116DNA conformation change (GO:0071103)2.51858689
117natural killer cell differentiation (GO:0001779)2.49792383
118regulation of mast cell degranulation (GO:0043304)2.49728000
119chromatin assembly or disassembly (GO:0006333)2.49719200
120negative regulation of mRNA metabolic process (GO:1903312)2.49550468
121positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49550092
122positive regulation of SMAD protein import into nucleus (GO:0060391)2.49086660
123negative regulation of viral release from host cell (GO:1902187)2.49039065
124regulation of RNA stability (GO:0043487)2.48990052
125adherens junction assembly (GO:0034333)2.48888292
126gene silencing (GO:0016458)2.48083690
127pentose-phosphate shunt (GO:0006098)2.47385785
128signal complex assembly (GO:0007172)2.47353205
129corticosteroid receptor signaling pathway (GO:0031958)2.47211883
130regulation of necroptotic process (GO:0060544)2.46513899
131chromatin silencing (GO:0006342)2.46352561
132negative regulation of cell size (GO:0045792)2.46112097
133monoubiquitinated protein deubiquitination (GO:0035520)2.45215742
134regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45048007
135nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.44681624
136negative regulation of toll-like receptor signaling pathway (GO:0034122)2.44369245
137focal adhesion assembly (GO:0048041)2.44172373
138cell-substrate adherens junction assembly (GO:0007045)2.44172373
139NLS-bearing protein import into nucleus (GO:0006607)2.43843195
140negative regulation of myotube differentiation (GO:0010832)2.43171906
141regulation of interferon-beta biosynthetic process (GO:0045357)2.43122339
142B cell receptor signaling pathway (GO:0050853)2.41107156
143cellular response to virus (GO:0098586)2.41087136
144positive T cell selection (GO:0043368)2.40973382
145thymic T cell selection (GO:0045061)2.40205797
146regulation of ARF GTPase activity (GO:0032312)2.39811895
147DNA strand elongation involved in DNA replication (GO:0006271)2.39681126
148response to host (GO:0075136)2.38800683
149response to host defenses (GO:0052200)2.38800683
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38800683
151intracellular estrogen receptor signaling pathway (GO:0030520)2.38799651
152negative regulation of gene expression, epigenetic (GO:0045814)2.38701659
153mitotic G1/S transition checkpoint (GO:0044819)2.38631803
154activation of MAPKKK activity (GO:0000185)2.38332316
155response to host immune response (GO:0052572)2.38262659
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38262659
157negative regulation of mRNA processing (GO:0050686)2.37934486
158spliceosomal tri-snRNP complex assembly (GO:0000244)2.37153451
159regulation of NFAT protein import into nucleus (GO:0051532)2.36677373
160mitotic metaphase plate congression (GO:0007080)2.36200854
161negative regulation of lymphocyte mediated immunity (GO:0002707)2.36080372
162regulation of B cell receptor signaling pathway (GO:0050855)2.36025264
163negative thymic T cell selection (GO:0045060)2.35662680
164response to interleukin-15 (GO:0070672)2.35628914
165negative regulation of histone modification (GO:0031057)2.35435145
166positive regulation of protein deacetylation (GO:0090312)2.35041087
167DNA replication initiation (GO:0006270)2.34756125
168negative regulation of leukocyte mediated immunity (GO:0002704)2.34140847
169respiratory burst (GO:0045730)2.33831181
170proline biosynthetic process (GO:0006561)2.33747144
171histone mRNA catabolic process (GO:0071044)2.32969547
172regulation of superoxide anion generation (GO:0032928)2.32962119
173morphogenesis of an endothelium (GO:0003159)2.32535776
174endothelial tube morphogenesis (GO:0061154)2.32535776
175negative regulation of DNA repair (GO:0045738)2.32477458
176ribosome assembly (GO:0042255)2.32167181
177positive regulation of nuclease activity (GO:0032075)2.31526462
178DNA strand elongation (GO:0022616)2.30284828
179positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29966494
180DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.29932841
181histone lysine demethylation (GO:0070076)2.29352456
182detection of biotic stimulus (GO:0009595)2.29138553
183positive regulation of mitotic sister chromatid separation (GO:1901970)2.28997289
184positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.28997289
185positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.28250109

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.88910569
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.02375941
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.58909153
4MYC_22102868_ChIP-Seq_BL_Human3.42223350
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90892427
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70262124
7LXR_22292898_ChIP-Seq_THP-1_Human2.44404808
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.43501101
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33330896
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31342696
11VDR_21846776_ChIP-Seq_THP-1_Human2.21485869
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11166312
13MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97618003
14TCF7_22412390_ChIP-Seq_EML_Mouse1.94030631
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91718358
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75289189
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74589363
18AR_21909140_ChIP-Seq_LNCAP_Human1.69911699
19MAF_26560356_Chip-Seq_TH1_Human1.69030392
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66666885
21ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65129668
22UTX_26944678_Chip-Seq_JUKART_Human1.64705471
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63969218
24KDM2B_26808549_Chip-Seq_DND41_Human1.63305652
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.62318119
26* KDM2B_26808549_Chip-Seq_K562_Human1.62304301
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57911638
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57339601
29CIITA_25753668_ChIP-Seq_RAJI_Human1.57020771
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55805525
31* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53671409
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46990139
33MYB_26560356_Chip-Seq_TH1_Human1.45750535
34CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44698710
35KDM5A_27292631_Chip-Seq_BREAST_Human1.44240356
36XRN2_22483619_ChIP-Seq_HELA_Human1.43942141
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43312546
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42744481
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42665067
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40270656
41P68_20966046_ChIP-Seq_HELA_Human1.39456354
42MYB_26560356_Chip-Seq_TH2_Human1.38763197
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38090974
44* SA1_27219007_Chip-Seq_ERYTHROID_Human1.37759268
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36995726
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36481127
47* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35239660
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35050409
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34768986
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34571365
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34235174
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33948942
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32906294
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32088563
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.30002510
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29134617
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29032869
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28818698
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28783945
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28170586
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27772273
62CLOCK_20551151_ChIP-Seq_293T_Human1.26338244
63* TET1_21451524_ChIP-Seq_MESCs_Mouse1.26188191
64* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26179536
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25254033
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24537070
67SPI1_23127762_ChIP-Seq_K562_Human1.23490944
68NCOR1_26117541_ChIP-Seq_K562_Human1.23077675
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22832254
70ATF3_27146783_Chip-Seq_COLON_Human1.22725329
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.21936081
72SMC4_20622854_ChIP-Seq_HELA_Human1.21738816
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21672089
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20967823
75* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20871954
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.20190635
77ZNF263_19887448_ChIP-Seq_K562_Human1.19850241
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19322233
79VDR_24763502_ChIP-Seq_THP-1_Human1.19182555
80CREB1_26743006_Chip-Seq_LNCaP_Human1.19095054
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19092583
82TFEB_21752829_ChIP-Seq_HELA_Human1.18905375
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18537147
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18535940
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18449594
86SCL_19346495_ChIP-Seq_HPC-7_Human1.18077039
87TP63_17297297_ChIP-ChIP_HaCaT_Human1.17749770
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17491507
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17438992
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16931357
91* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16806642
92MAF_26560356_Chip-Seq_TH2_Human1.14102302
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13223684
94* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12488752
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11636468
96* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11285669
97BCOR_27268052_Chip-Seq_Bcells_Human1.10867647
98CHD1_26751641_Chip-Seq_LNCaP_Human1.09713229
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09688158
100* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09085491
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07831994
102RACK7_27058665_Chip-Seq_MCF-7_Human1.07538522
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07378886
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06621501
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06407325
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.06404224
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05648822
108ELF1_20517297_ChIP-Seq_JURKAT_Human1.05643692
109* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05261546
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04769376
111IRF8_22096565_ChIP-ChIP_GC-B_Human1.04691177
112* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04540511
113* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04127708
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04061471
115FOXP3_21729870_ChIP-Seq_TREG_Human1.03554610
116* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02953638
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.02495834
118GATA1_19941826_ChIP-Seq_K562_Human1.02061540
119* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01864494
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01605992
121GABP_19822575_ChIP-Seq_HepG2_Human1.01472039
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.01099109
123VDR_23849224_ChIP-Seq_CD4+_Human1.00042201
124* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99219989
125SPI1_23547873_ChIP-Seq_NB4_Human0.99188237
126KDM2B_26808549_Chip-Seq_JURKAT_Human0.98729545
127IRF8_27001747_Chip-Seq_BMDM_Mouse0.98623757
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98324775
129BCL6_27268052_Chip-Seq_Bcells_Human0.98080431
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97809308
131KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97553067
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96297145
133PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96192448
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95247761
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94540898
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92968440
137ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92530672
138DCP1A_22483619_ChIP-Seq_HELA_Human0.91871695
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91661414
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91493161
141TTF2_22483619_ChIP-Seq_HELA_Human0.87543561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.28360660
2MP0003705_abnormal_hypodermis_morpholog3.11410014
3MP0010352_gastrointestinal_tract_polyps3.04620303
4MP0005058_abnormal_lysosome_morphology2.72670405
5MP0008260_abnormal_autophagy2.66967599
6MP0003693_abnormal_embryo_hatching2.44696778
7MP0005076_abnormal_cell_differentiation2.44279710
8MP0003111_abnormal_nucleus_morphology2.42378777
9MP0003077_abnormal_cell_cycle2.41568072
10MP0004957_abnormal_blastocyst_morpholog2.32748467
11MP0010094_abnormal_chromosome_stability2.32448121
12MP0003172_abnormal_lysosome_physiology2.27106276
13MP0002396_abnormal_hematopoietic_system2.17179934
14MP0008057_abnormal_DNA_replication2.09676218
15MP0009278_abnormal_bone_marrow2.05692898
16MP0003300_gastrointestinal_ulcer2.03060339
17MP0004808_abnormal_hematopoietic_stem2.01791143
18MP0003763_abnormal_thymus_physiology1.92935159
19MP0002877_abnormal_melanocyte_morpholog1.90665786
20MP0001730_embryonic_growth_arrest1.90428618
21MP0010307_abnormal_tumor_latency1.87846872
22MP0002419_abnormal_innate_immunity1.85611779
23MP0003566_abnormal_cell_adhesion1.81479197
24MP0005025_abnormal_response_to1.78578357
25MP0003191_abnormal_cellular_cholesterol1.76397426
26MP0000350_abnormal_cell_proliferation1.75794228
27MP0004381_abnormal_hair_follicle1.73226088
28MP0003303_peritoneal_inflammation1.68395311
29MP0000490_abnormal_crypts_of1.66008091
30MP0004858_abnormal_nervous_system1.62039683
31MP0000678_abnormal_parathyroid_gland1.57377051
32MP0001545_abnormal_hematopoietic_system1.52290131
33MP0005397_hematopoietic_system_phenotyp1.52290131
34MP0008007_abnormal_cellular_replicative1.49876656
35MP0004197_abnormal_fetal_growth/weight/1.49728252
36MP0010234_abnormal_vibrissa_follicle1.48896196
37MP0000685_abnormal_immune_system1.48463211
38MP0003724_increased_susceptibility_to1.46180706
39MP0000703_abnormal_thymus_morphology1.44876365
40* MP0005380_embryogenesis_phenotype1.44648677
41* MP0001672_abnormal_embryogenesis/_devel1.44648677
42* MP0002086_abnormal_extraembryonic_tissu1.44338464
43* MP0002088_abnormal_embryonic_growth/wei1.42105165
44MP0002398_abnormal_bone_marrow1.41555551
45* MP0003984_embryonic_growth_retardation1.41503097
46MP0009333_abnormal_splenocyte_physiolog1.39067408
47* MP0001697_abnormal_embryo_size1.36812267
48MP0005023_abnormal_wound_healing1.35554747
49MP0002132_abnormal_respiratory_system1.32056432
50MP0005409_darkened_coat_color1.31879004
51MP0002019_abnormal_tumor_incidence1.30806024
52MP0002796_impaired_skin_barrier1.30185680
53* MP0002084_abnormal_developmental_patter1.30008815
54* MP0002080_prenatal_lethality1.27918402
55MP0001533_abnormal_skeleton_physiology1.26858411
56MP0002722_abnormal_immune_system1.26630054
57MP0004185_abnormal_adipocyte_glucose1.25846262
58MP0006082_CNS_inflammation1.25384944
59MP0001800_abnormal_humoral_immune1.23756627
60MP0000689_abnormal_spleen_morphology1.23591061
61MP0001849_ear_inflammation1.22723088
62MP0000733_abnormal_muscle_development1.22441601
63MP0006054_spinal_hemorrhage1.20828625
64* MP0002085_abnormal_embryonic_tissue1.19250371
65MP0004947_skin_inflammation1.17672032
66MP0002998_abnormal_bone_remodeling1.16236620
67MP0009785_altered_susceptibility_to1.14737421
68MP0002254_reproductive_system_inflammat1.14103324
69MP0002166_altered_tumor_susceptibility1.11702688
70MP0003567_abnormal_fetal_cardiomyocyte1.10832591
71MP0002405_respiratory_system_inflammati1.10013896
72MP0001915_intracranial_hemorrhage1.08807118
73MP0008058_abnormal_DNA_repair1.07535056
74MP0002148_abnormal_hypersensitivity_rea1.05150798
75MP0010155_abnormal_intestine_physiology1.04717592
76MP0000313_abnormal_cell_death1.04588353
77MP0000716_abnormal_immune_system1.04222405
78MP0001873_stomach_inflammation1.03690710
79MP0002429_abnormal_blood_cell1.03594289
80MP0003436_decreased_susceptibility_to1.03407900
81MP0004233_abnormal_muscle_weight1.03382628
82MP0002089_abnormal_postnatal_growth/wei1.02361575
83MP0005375_adipose_tissue_phenotype1.02170979
84MP0009672_abnormal_birth_weight1.01412803
85MP0001851_eye_inflammation1.00323208
86MP0001845_abnormal_inflammatory_respons1.00096243
87MP0005501_abnormal_skin_physiology0.99304607
88MP0009840_abnormal_foam_cell0.98753491
89MP0008438_abnormal_cutaneous_collagen0.98549882
90MP0002452_abnormal_antigen_presenting0.98469634
91MP0002420_abnormal_adaptive_immunity0.97205464
92MP0009053_abnormal_anal_canal0.96904620
93MP0000858_altered_metastatic_potential0.95623383
94MP0001819_abnormal_immune_cell0.95437177
95MP0002138_abnormal_hepatobiliary_system0.95113382
96MP0004264_abnormal_extraembryonic_tissu0.94218465
97MP0003828_pulmonary_edema0.94147365
98MP0009931_abnormal_skin_appearance0.90924617
99MP0008932_abnormal_embryonic_tissue0.90913300
100MP0003091_abnormal_cell_migration0.89823208
101MP0005310_abnormal_salivary_gland0.89600616
102MP0004510_myositis0.88973274
103MP0003453_abnormal_keratinocyte_physiol0.88797669
104MP0008877_abnormal_DNA_methylation0.88525364
105MP0009703_decreased_birth_body0.88522087
106MP0001348_abnormal_lacrimal_gland0.87804486
107MP0002723_abnormal_immune_serum0.87673179
108MP0001790_abnormal_immune_system0.87253396
109MP0005387_immune_system_phenotype0.87253396
110* MP0000477_abnormal_intestine_morphology0.87199107
111MP0002249_abnormal_larynx_morphology0.86238711
112MP0003786_premature_aging0.86178514
113MP0008961_abnormal_basal_metabolism0.85633030
114MP0003866_abnormal_defecation0.85458664
115MP0005671_abnormal_response_to0.82357631
116MP0003221_abnormal_cardiomyocyte_apopto0.81164265
117MP0005621_abnormal_cell_physiology0.81019080
118MP0003943_abnormal_hepatobiliary_system0.80946413
119* MP0002925_abnormal_cardiovascular_devel0.80398947
120MP0008469_abnormal_protein_level0.78842076
121MP0005666_abnormal_adipose_tissue0.78566361
122MP0003448_altered_tumor_morphology0.78406402
123MP0003183_abnormal_peptide_metabolism0.77990635
124MP0002092_abnormal_eye_morphology0.76829228
125MP0001216_abnormal_epidermal_layer0.76120066
126MP0005464_abnormal_platelet_physiology0.75418054
127MP0005000_abnormal_immune_tolerance0.75402562
128MP0005083_abnormal_biliary_tract0.75116659
129MP0010630_abnormal_cardiac_muscle0.75022749
130MP0000465_gastrointestinal_hemorrhage0.73450087
131MP0000598_abnormal_liver_morphology0.72363051
132MP0002006_tumorigenesis0.72259552
133MP0001853_heart_inflammation0.72152504
134MP0001835_abnormal_antigen_presentation0.71553756
135MP0002060_abnormal_skin_morphology0.68721770
136MP0003115_abnormal_respiratory_system0.67768769

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.05870521
2Abnormality of macrophages (HP:0004311)3.20836332
3Recurrent abscess formation (HP:0002722)3.20266259
4Recurrent bacterial skin infections (HP:0005406)3.18246767
5Selective tooth agenesis (HP:0001592)3.15630439
6Cerebral aneurysm (HP:0004944)3.01377632
7Abnormality of the fingertips (HP:0001211)2.85065706
8Increased density of long bones (HP:0006392)2.70925780
9Hyperacusis (HP:0010780)2.70892533
10Protrusio acetabuli (HP:0003179)2.69210648
11Ependymoma (HP:0002888)2.68030879
12Deviation of the thumb (HP:0009603)2.53620145
13Chronic obstructive pulmonary disease (HP:0006510)2.51701368
14Obstructive lung disease (HP:0006536)2.51701368
15Volvulus (HP:0002580)2.49928375
16Proximal placement of thumb (HP:0009623)2.48612753
17Ankle contracture (HP:0006466)2.47649893
18T lymphocytopenia (HP:0005403)2.45428351
19Ulnar bowing (HP:0003031)2.44757638
20Broad face (HP:0000283)2.44420550
21Basal cell carcinoma (HP:0002671)2.43781111
22Myositis (HP:0100614)2.43684582
23Increased IgE level (HP:0003212)2.38400999
24Thrombocytosis (HP:0001894)2.37934147
25Gastrointestinal infarctions (HP:0005244)2.36959393
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33687118
27Short 4th metacarpal (HP:0010044)2.33687118
28Mediastinal lymphadenopathy (HP:0100721)2.31771269
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30086314
30Slow saccadic eye movements (HP:0000514)2.29489724
31Mitral valve prolapse (HP:0001634)2.29317049
32Prominent nose (HP:0000448)2.27406610
33Gingivitis (HP:0000230)2.26906958
34IgM deficiency (HP:0002850)2.26475485
35Asymmetry of the thorax (HP:0001555)2.25858565
36Increased nuchal translucency (HP:0010880)2.24051022
37Colon cancer (HP:0003003)2.22951400
38Disproportionate tall stature (HP:0001519)2.22177415
39High pitched voice (HP:0001620)2.21465623
40Abnormality of T cell number (HP:0011839)2.20221261
41Thin bony cortex (HP:0002753)2.19939550
42Recurrent gram-negative bacterial infections (HP:0005420)2.19159964
43Inflammation of the large intestine (HP:0002037)2.18981008
44Rectal prolapse (HP:0002035)2.16280007
45Distal lower limb amyotrophy (HP:0008944)2.15616801
46Increased cerebral lipofuscin (HP:0011813)2.14631869
47Hand muscle atrophy (HP:0009130)2.14152442
48Nasal polyposis (HP:0100582)2.13709016
49Obstructive sleep apnea (HP:0002870)2.13615621
50Orchitis (HP:0100796)2.13374626
51Hemorrhage of the eye (HP:0011885)2.12873801
52Genu recurvatum (HP:0002816)2.10758641
53Increased serum ferritin (HP:0003281)2.10259604
54Recurrent viral infections (HP:0004429)2.10184224
55Segmental peripheral demyelination/remyelination (HP:0003481)2.09466150
56Missing ribs (HP:0000921)2.08262033
57Meningitis (HP:0001287)2.07307095
58Increased connective tissue (HP:0009025)2.06922822
59Polygenic inheritance (HP:0010982)2.06433382
60Upper limb amyotrophy (HP:0009129)2.02950276
61Distal upper limb amyotrophy (HP:0007149)2.02950276
62Abnormality of the calcaneus (HP:0008364)2.02764509
63Squamous cell carcinoma (HP:0002860)2.01933988
64Flat acetabular roof (HP:0003180)2.01055939
65Astrocytoma (HP:0009592)2.00790416
66Abnormality of the astrocytes (HP:0100707)2.00790416
67Dysostosis multiplex (HP:0000943)2.00230267
68Prolonged bleeding time (HP:0003010)1.99895787
69Malignant gastrointestinal tract tumors (HP:0006749)1.98817321
70Gastrointestinal carcinoma (HP:0002672)1.98817321
71Centrally nucleated skeletal muscle fibers (HP:0003687)1.98601714
72Deep venous thrombosis (HP:0002625)1.98178935
73Long palpebral fissure (HP:0000637)1.97482863
74Abnormality of the peritoneum (HP:0002585)1.97190597
75Macroorchidism (HP:0000053)1.96865431
76Heterotopia (HP:0002282)1.96758291
77Recurrent bronchitis (HP:0002837)1.95146571
78Aortic aneurysm (HP:0004942)1.94887216
79Biliary tract neoplasm (HP:0100574)1.94322578
80Shallow orbits (HP:0000586)1.93808475
81Easy fatigability (HP:0003388)1.93409440
82Metaphyseal cupping (HP:0003021)1.92309361
83Syringomyelia (HP:0003396)1.90886417
84Spinal cord lesions (HP:0100561)1.90886417
85Cellulitis (HP:0100658)1.90747276
86Recurrent skin infections (HP:0001581)1.89033188
87Abnormality of the thoracic spine (HP:0100711)1.88781764
88Loss of speech (HP:0002371)1.88440011
89Achilles tendon contracture (HP:0001771)1.88033777
90Increased neuronal autofluorescent lipopigment (HP:0002074)1.86693130
91Rhabdomyosarcoma (HP:0002859)1.85149163
9211 pairs of ribs (HP:0000878)1.84189543
93Abnormality of T cells (HP:0002843)1.84060178
94Long eyelashes (HP:0000527)1.83739628
95Vertebral compression fractures (HP:0002953)1.83707825
96Dilatation of the ascending aorta (HP:0005111)1.83513026
97Abnormality of the 4th metacarpal (HP:0010012)1.83443228
98Abnormal platelet volume (HP:0011876)1.82562243
99Hematochezia (HP:0002573)1.82260258
100Papilloma (HP:0012740)1.82060374
101Verrucae (HP:0200043)1.82060374
102Increased mean platelet volume (HP:0011877)1.82026342
103Broad palm (HP:0001169)1.81778247
104Dysmetric saccades (HP:0000641)1.81683992
105Peritonitis (HP:0002586)1.81678450
106Pustule (HP:0200039)1.78533909
107Cutaneous melanoma (HP:0012056)1.77566928
108Bowel diverticulosis (HP:0005222)1.77026322
109Hypertensive crisis (HP:0100735)1.76915522
110Renal duplication (HP:0000075)1.76425005
111Osteolytic defects of the phalanges of the hand (HP:0009771)1.76007807
112Osteolytic defects of the hand bones (HP:0009699)1.76007807
113Abnormality of the distal phalanx of the thumb (HP:0009617)1.75615869
114Abnormality of the nasal mucosa (HP:0000433)1.75182779
115IgA deficiency (HP:0002720)1.74908572
116Aneurysm (HP:0002617)1.74216621
117Multiple enchondromatosis (HP:0005701)1.73133404
118Cholecystitis (HP:0001082)1.72925576
119Abnormal gallbladder physiology (HP:0012438)1.72925576
120Hypochromic anemia (HP:0001931)1.72178781
121Stridor (HP:0010307)1.71407222
122Optic neuritis (HP:0100653)1.71154904
123Retrobulbar optic neuritis (HP:0100654)1.71154904
124Premature rupture of membranes (HP:0001788)1.71005164
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70125574
126Seborrheic dermatitis (HP:0001051)1.69623091
127Cutis marmorata (HP:0000965)1.69517417
128Abnormality of the Achilles tendon (HP:0005109)1.69111773
129Thoracic kyphosis (HP:0002942)1.68984554
130Ankyloglossia (HP:0010296)1.68947096
131Reticulocytosis (HP:0001923)1.67634588
132Renovascular hypertension (HP:0100817)1.67564871
133Hypertriglyceridemia (HP:0002155)1.67406243
134Abnormality of cells of the erythroid lineage (HP:0012130)1.67223722
135Neoplasm of striated muscle (HP:0009728)1.66965043
136Bicuspid aortic valve (HP:0001647)1.66894880
137Dislocated radial head (HP:0003083)1.66603273
138Premature skin wrinkling (HP:0100678)1.66339621
139Spontaneous hematomas (HP:0007420)1.66117195
140Sandal gap (HP:0001852)1.65837840
141Epistaxis (HP:0000421)1.65682440
142Pseudobulbar signs (HP:0002200)1.65455804
143Deep palmar crease (HP:0006191)1.65126530
144Fibrous tissue neoplasm (HP:0012316)1.65060331
145Gastrointestinal inflammation (HP:0004386)1.64563269
146Urticaria (HP:0001025)1.64518337
147Persistence of primary teeth (HP:0006335)1.64259019
148Interstitial pulmonary disease (HP:0006530)1.62947803
149Purpura (HP:0000979)1.62457231
150Fatigue (HP:0012378)1.62136000
151Skin tags (HP:0010609)1.62003056
152Arterial thrombosis (HP:0004420)1.61917716
153Gastrointestinal dysmotility (HP:0002579)1.61878599
154Biconcave vertebral bodies (HP:0004586)1.61645411
155Abnormality of oral frenula (HP:0000190)1.61095988
156Abnormal vertebral ossification (HP:0100569)1.61081800
157Myocardial infarction (HP:0001658)1.60864134
158Cafe-au-lait spot (HP:0000957)1.60195507
159Mucopolysacchariduria (HP:0008155)1.60066831
160Urinary glycosaminoglycan excretion (HP:0003541)1.60066831
161Cervical subluxation (HP:0003308)1.60025403
162Fibroma (HP:0010614)1.59827270
163Germ cell neoplasia (HP:0100728)1.59784806
164Abnormal platelet function (HP:0011869)1.59411645
165Impaired platelet aggregation (HP:0003540)1.59411645
166Progressive external ophthalmoplegia (HP:0000590)1.59188306
167Colitis (HP:0002583)1.58668854
168Broad distal phalanx of finger (HP:0009836)1.58403142
169Osteomyelitis (HP:0002754)1.57445631
170Ragged-red muscle fibers (HP:0003200)1.57444850
171Degeneration of anterior horn cells (HP:0002398)1.57256757
172Abnormality of the anterior horn cell (HP:0006802)1.57256757
173Hallux valgus (HP:0001822)1.57014811
174Abnormal number of erythroid precursors (HP:0012131)1.55555410
175Blepharitis (HP:0000498)1.55357001
176Recurrent fungal infections (HP:0002841)1.55051660
177Angiofibromas (HP:0010615)1.54910261
178Adenoma sebaceum (HP:0009720)1.54910261
179Abnormality of the radial head (HP:0003995)1.54760677
180Distal lower limb muscle weakness (HP:0009053)1.54506332
181Amaurosis fugax (HP:0100576)1.54393226
182Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.53503453
183Broad thumb (HP:0011304)1.53409304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.74053581
2PRPF4B3.63625375
3EEF2K3.56169298
4PKN23.37686896
5CDK123.35604705
6MAP3K103.30462886
7SMG13.17671425
8IRAK32.79732122
9CDC72.64714103
10STK102.45778837
11NEK22.35520102
12MAP4K12.33812756
13RIPK42.32645516
14STK32.09079763
15ERN12.08514793
16PTK61.94582414
17MAP3K131.87468931
18IRAK41.87281664
19CDK41.76167967
20LRRK21.75369773
21RIPK11.67870072
22RPS6KA41.48433682
23LATS11.48177283
24TTN1.47553017
25GRK61.40547285
26MAP3K81.38659888
27TAOK21.32600918
28PASK1.29873520
29TTK1.28208074
30ALK1.27962818
31RPS6KB21.26379182
32CDK61.26099046
33MARK21.25703143
34WEE11.24724343
35FLT31.23565428
36MAP3K141.22554592
37MTOR1.19061965
38TYK21.19039358
39JAK31.18746266
40KSR21.18488348
41DYRK31.17724777
42MAP3K11.14809297
43SCYL21.13988523
44PDGFRA1.13756025
45FGFR41.09684662
46PAK41.09023627
47ZAP701.08697405
48CDK71.08578867
49BMX1.07231220
50IRAK21.06506963
51BLK1.04200728
52PIM11.03605519
53SIK11.02190552
54SIK31.02115578
55MAP2K30.96168714
56ICK0.91689884
57CDC42BPA0.91519168
58PDPK10.91255095
59FES0.90716278
60TNK20.88421697
61TGFBR10.88110763
62STK40.87467276
63CHEK10.86768132
64ATR0.83835264
65MELK0.82595094
66PAK20.81293852
67STK240.81253982
68RPS6KL10.79126379
69RPS6KC10.79126379
70MST1R0.78740980
71AURKB0.77789435
72BRD40.76960929
73BTK0.76882535
74FGR0.74951597
75CSK0.74943511
76ITK0.74438981
77TYRO30.74155059
78NEK10.73011304
79EPHA20.72139325
80RPS6KA20.71971114
81PDGFRB0.71299129
82TSSK60.70823071
83TAOK10.67942204
84TBK10.66858720
85CDK90.66097699
86NME20.65929491
87PDK10.65481973
88MAP3K60.64389289
89LATS20.62931656
90FGFR30.61572688
91CSF1R0.60430187
92* CDK20.60371907
93HIPK20.60044723
94* PLK10.59982083
95MAP3K30.59067176
96MARK30.58490520
97CAMK1D0.57570503
98ACVR1B0.57319214
99MAP2K20.57118826
100EPHB10.57044536
101ARAF0.56080641
102KIT0.56062112
103RPS6KA60.55970537
104CHUK0.55594187
105ATM0.54964957
106IKBKE0.53826422
107JAK10.53517766
108BUB10.52767035
109PRKD20.52307207
110MAP3K20.51662474
111DMPK0.51424418
112PTK20.49905210
113HCK0.49524514
114BRSK20.49489670
115IKBKB0.48456795
116MAPK120.48208022
117FGFR10.48098653
118TESK20.47552606
119JAK20.47118479
120MAP3K110.47008164
121CHEK20.46244608
122MAPK110.45852514
123IRAK10.45700368
124BRAF0.45184790
125NLK0.43951169
126LCK0.42600337
127MATK0.40562000
128CAMKK10.39997222
129LYN0.38536554
130RPS6KA10.38018747
131SIK20.37657360
132PRKG20.37388517
133ILK0.37119272
134SYK0.36338292
135TAOK30.35871508
136MAPKAPK20.35441827
137MAP3K70.34640850
138SGK30.33526593
139RET0.33333664

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.58543036
2DNA replication_Homo sapiens_hsa030302.57128188
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.55060413
4One carbon pool by folate_Homo sapiens_hsa006702.36060368
5RNA transport_Homo sapiens_hsa030132.17529345
6Cell cycle_Homo sapiens_hsa041102.07317950
7Mismatch repair_Homo sapiens_hsa034302.04653804
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96153642
9Spliceosome_Homo sapiens_hsa030401.87177843
10Chronic myeloid leukemia_Homo sapiens_hsa052201.84692667
11Antigen processing and presentation_Homo sapiens_hsa046121.77526654
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.75487014
13Small cell lung cancer_Homo sapiens_hsa052221.69813300
14mRNA surveillance pathway_Homo sapiens_hsa030151.65987061
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59783126
16Base excision repair_Homo sapiens_hsa034101.56258832
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54977754
18Viral carcinogenesis_Homo sapiens_hsa052031.47143753
19Acute myeloid leukemia_Homo sapiens_hsa052211.46487935
20p53 signaling pathway_Homo sapiens_hsa041151.45913837
21B cell receptor signaling pathway_Homo sapiens_hsa046621.42607152
22Primary immunodeficiency_Homo sapiens_hsa053401.42426393
23MicroRNAs in cancer_Homo sapiens_hsa052061.40924885
24Herpes simplex infection_Homo sapiens_hsa051681.29502078
25HTLV-I infection_Homo sapiens_hsa051661.29014096
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.27396685
27mTOR signaling pathway_Homo sapiens_hsa041501.26266152
28Thyroid cancer_Homo sapiens_hsa052161.25922805
29Lysine degradation_Homo sapiens_hsa003101.23728692
30Selenocompound metabolism_Homo sapiens_hsa004501.23276562
31Non-small cell lung cancer_Homo sapiens_hsa052231.20157675
32Pancreatic cancer_Homo sapiens_hsa052121.19304651
33Measles_Homo sapiens_hsa051621.17842875
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16951053
35Tuberculosis_Homo sapiens_hsa051521.16599776
36Toxoplasmosis_Homo sapiens_hsa051451.16310166
37Epstein-Barr virus infection_Homo sapiens_hsa051691.15566769
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14480644
39T cell receptor signaling pathway_Homo sapiens_hsa046601.14125258
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12072273
41Apoptosis_Homo sapiens_hsa042101.11262930
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09515172
43Notch signaling pathway_Homo sapiens_hsa043301.09220368
44Viral myocarditis_Homo sapiens_hsa054161.08663805
45Hepatitis B_Homo sapiens_hsa051611.08127569
46ErbB signaling pathway_Homo sapiens_hsa040121.08105222
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.05428740
48Adherens junction_Homo sapiens_hsa045201.04983938
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.04837999
50* Colorectal cancer_Homo sapiens_hsa052101.03666388
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.02052895
52Proteoglycans in cancer_Homo sapiens_hsa052051.01699808
53Non-homologous end-joining_Homo sapiens_hsa034501.00569660
54Nucleotide excision repair_Homo sapiens_hsa034201.00310176
55Osteoclast differentiation_Homo sapiens_hsa043800.99955420
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99712045
57Malaria_Homo sapiens_hsa051440.99465359
58Leishmaniasis_Homo sapiens_hsa051400.98851872
59Fructose and mannose metabolism_Homo sapiens_hsa000510.97823549
60Bladder cancer_Homo sapiens_hsa052190.96974398
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96861236
62Chemokine signaling pathway_Homo sapiens_hsa040620.96319060
63Galactose metabolism_Homo sapiens_hsa000520.95277018
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93817382
65Staphylococcus aureus infection_Homo sapiens_hsa051500.93782712
66Choline metabolism in cancer_Homo sapiens_hsa052310.93246473
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93137376
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91237554
69Homologous recombination_Homo sapiens_hsa034400.90182094
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.89233555
71Prostate cancer_Homo sapiens_hsa052150.89156567
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.89092546
73Inositol phosphate metabolism_Homo sapiens_hsa005620.88361970
74Focal adhesion_Homo sapiens_hsa045100.88025564
75Insulin resistance_Homo sapiens_hsa049310.86848774
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84897400
77GnRH signaling pathway_Homo sapiens_hsa049120.83943975
78Influenza A_Homo sapiens_hsa051640.82482562
79VEGF signaling pathway_Homo sapiens_hsa043700.82397947
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.82157601
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82068797
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82010866
83Ribosome_Homo sapiens_hsa030100.81614815
84RNA degradation_Homo sapiens_hsa030180.81130098
85* Endometrial cancer_Homo sapiens_hsa052130.80224842
86TGF-beta signaling pathway_Homo sapiens_hsa043500.79355509
87Prolactin signaling pathway_Homo sapiens_hsa049170.79346124
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78959644
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.78431591
90Endocytosis_Homo sapiens_hsa041440.78363996
91Legionellosis_Homo sapiens_hsa051340.78312111
92Graft-versus-host disease_Homo sapiens_hsa053320.78074117
93Prion diseases_Homo sapiens_hsa050200.77500819
94Salmonella infection_Homo sapiens_hsa051320.76857182
95Shigellosis_Homo sapiens_hsa051310.76349609
96* Hippo signaling pathway_Homo sapiens_hsa043900.75875776
97Lysosome_Homo sapiens_hsa041420.74953572
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73678045
99TNF signaling pathway_Homo sapiens_hsa046680.72565389
100RNA polymerase_Homo sapiens_hsa030200.71368845
101Pentose phosphate pathway_Homo sapiens_hsa000300.71139727
102Fanconi anemia pathway_Homo sapiens_hsa034600.70969861
103Allograft rejection_Homo sapiens_hsa053300.69183617
104FoxO signaling pathway_Homo sapiens_hsa040680.69062381
105* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68104843
106Renal cell carcinoma_Homo sapiens_hsa052110.67968440
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67849294
108Hematopoietic cell lineage_Homo sapiens_hsa046400.67449673
109HIF-1 signaling pathway_Homo sapiens_hsa040660.65746118
110Estrogen signaling pathway_Homo sapiens_hsa049150.65532521
111Platelet activation_Homo sapiens_hsa046110.65183227
112Biosynthesis of amino acids_Homo sapiens_hsa012300.65122274
113* Pathways in cancer_Homo sapiens_hsa052000.64527614
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63464339
115Type II diabetes mellitus_Homo sapiens_hsa049300.62016112
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61672662
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.60724587
118Pyrimidine metabolism_Homo sapiens_hsa002400.60513072
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59829030
120Systemic lupus erythematosus_Homo sapiens_hsa053220.58281122
121Pertussis_Homo sapiens_hsa051330.57503476
122Autoimmune thyroid disease_Homo sapiens_hsa053200.57367435
123AMPK signaling pathway_Homo sapiens_hsa041520.57363139
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54276638
125African trypanosomiasis_Homo sapiens_hsa051430.54050295
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53807661
127ECM-receptor interaction_Homo sapiens_hsa045120.53803920
128MAPK signaling pathway_Homo sapiens_hsa040100.53803373
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.53145669
130Amoebiasis_Homo sapiens_hsa051460.52985903
131Hepatitis C_Homo sapiens_hsa051600.51422142
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51033624
133Dorso-ventral axis formation_Homo sapiens_hsa043200.50950451
134Glioma_Homo sapiens_hsa052140.50353691
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49630849
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48308187
137Sulfur relay system_Homo sapiens_hsa041220.47372762
138Insulin signaling pathway_Homo sapiens_hsa049100.47158528

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