AXIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of catenin import into nucleus (GO:0035413)5.18581965
2receptor catabolic process (GO:0032801)5.06364183
3lateral sprouting from an epithelium (GO:0060601)4.97343832
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.92031627
5cranial suture morphogenesis (GO:0060363)4.82101945
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.67744547
7mesenchymal cell proliferation (GO:0010463)4.19828903
8head development (GO:0060322)4.18313625
9intestinal epithelial cell development (GO:0060576)4.07275819
10pre-miRNA processing (GO:0031054)4.02801196
11paraxial mesoderm development (GO:0048339)3.89811851
12positive regulation of dendritic spine morphogenesis (GO:0061003)3.83770851
13regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.79244252
14notochord development (GO:0030903)3.70963675
15convergent extension (GO:0060026)3.68500165
16anterior/posterior axis specification, embryo (GO:0008595)3.67837990
17mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.66092340
18cell proliferation involved in kidney development (GO:0072111)3.64038514
19hippo signaling (GO:0035329)3.51761017
20non-canonical Wnt signaling pathway (GO:0035567)3.47340366
21Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.46941200
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.43856016
23regulation of establishment of planar polarity (GO:0090175)3.38466039
24regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.38358949
25embryonic hindlimb morphogenesis (GO:0035116)3.37631845
26establishment of apical/basal cell polarity (GO:0035089)3.36547267
27establishment of tissue polarity (GO:0007164)3.34716377
28establishment of planar polarity (GO:0001736)3.34716377
29polarized epithelial cell differentiation (GO:0030859)3.34698268
30hindlimb morphogenesis (GO:0035137)3.33700838
31embryonic foregut morphogenesis (GO:0048617)3.24704114
32layer formation in cerebral cortex (GO:0021819)3.24664540
33regulation of cholesterol homeostasis (GO:2000188)3.23512175
34embryonic retina morphogenesis in camera-type eye (GO:0060059)3.20150048
35cochlea morphogenesis (GO:0090103)3.19684655
36SMAD protein signal transduction (GO:0060395)3.15090105
37hemidesmosome assembly (GO:0031581)3.14919816
38positive regulation of SMAD protein import into nucleus (GO:0060391)3.14772462
39eyelid development in camera-type eye (GO:0061029)3.13434544
40negative regulation of glial cell proliferation (GO:0060253)3.12620707
41nuclear pore complex assembly (GO:0051292)3.10918166
42G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.08804843
43bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08362703
44gastrulation with mouth forming second (GO:0001702)3.07232115
45very-low-density lipoprotein particle assembly (GO:0034379)3.05524414
46midgut development (GO:0007494)2.98943011
47histone H3-K9 demethylation (GO:0033169)2.98373183
48photoreceptor cell differentiation (GO:0046530)2.96775760
49eye photoreceptor cell differentiation (GO:0001754)2.96775760
50collecting duct development (GO:0072044)2.94541489
51desmosome organization (GO:0002934)2.94335018
52plasma lipoprotein particle assembly (GO:0034377)2.93405049
53low-density lipoprotein particle clearance (GO:0034383)2.93387855
54face development (GO:0060324)2.93387314
55lung epithelium development (GO:0060428)2.91814850
56negative regulation of Ras GTPase activity (GO:0034261)2.91358600
57negative regulation of myoblast differentiation (GO:0045662)2.90422321
58establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.88246827
59radial glial cell differentiation (GO:0060019)2.87660317
60proximal/distal pattern formation (GO:0009954)2.87197156
61columnar/cuboidal epithelial cell development (GO:0002066)2.86560066
62cell proliferation involved in metanephros development (GO:0072203)2.85310189
63intracellular estrogen receptor signaling pathway (GO:0030520)2.85058359
64regulation of hippo signaling (GO:0035330)2.85050770
65outer ear morphogenesis (GO:0042473)2.84220156
66regulation of hair follicle development (GO:0051797)2.83489213
67renal system development (GO:0072001)2.82005627
68positive regulation of canonical Wnt signaling pathway (GO:0090263)2.80504637
69bone trabecula formation (GO:0060346)2.80310557
70regulation of bile acid biosynthetic process (GO:0070857)2.80146630
71body morphogenesis (GO:0010171)2.80006373
72axis elongation (GO:0003401)2.79261671
73negative regulation of epidermis development (GO:0045683)2.79086524
74trophectodermal cell differentiation (GO:0001829)2.78845787
75regulation of somitogenesis (GO:0014807)2.77762999
76establishment of monopolar cell polarity (GO:0061162)2.77657052
77establishment or maintenance of monopolar cell polarity (GO:0061339)2.77657052
78negative regulation of axon extension involved in axon guidance (GO:0048843)2.77562716
79embryonic camera-type eye development (GO:0031076)2.76890777
80neural tube closure (GO:0001843)2.75043251
81tube closure (GO:0060606)2.74730724
82respiratory tube development (GO:0030323)2.73088604
83epithelial cell differentiation involved in prostate gland development (GO:0060742)2.72582911
84embryonic forelimb morphogenesis (GO:0035115)2.72073224
85bone morphogenesis (GO:0060349)2.72043200
86nuclear pore organization (GO:0006999)2.71558737
87embryonic skeletal joint morphogenesis (GO:0060272)2.70710228
88regulation of non-canonical Wnt signaling pathway (GO:2000050)2.67834305
89endocardial cushion development (GO:0003197)2.67534025
90regulation of apoptotic cell clearance (GO:2000425)2.66077292
91protein-lipid complex assembly (GO:0065005)2.65259372
92regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.64941103
93cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64762624
94keratinocyte proliferation (GO:0043616)2.64719011
95craniofacial suture morphogenesis (GO:0097094)2.64199976
96histone H3-K36 demethylation (GO:0070544)2.64058643
97anterior/posterior axis specification (GO:0009948)2.63791023
98lung-associated mesenchyme development (GO:0060484)2.63505057
99* dorsal/ventral axis specification (GO:0009950)2.63375992
100regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.63085084
101glomerular visceral epithelial cell development (GO:0072015)2.62538855
102viral transcription (GO:0019083)2.61783189
103epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.61707402
104morphogenesis of an epithelial fold (GO:0060571)2.61579006
105cell migration involved in gastrulation (GO:0042074)2.60359888
106branching involved in mammary gland duct morphogenesis (GO:0060444)2.60211950
107ectodermal placode formation (GO:0060788)2.59569865
108cytoplasmic mRNA processing body assembly (GO:0033962)2.59362275
109* negative regulation of catenin import into nucleus (GO:0035414)2.59075598
110forelimb morphogenesis (GO:0035136)2.58702537
111cellular response to epidermal growth factor stimulus (GO:0071364)2.58330927
112positive regulation of hormone biosynthetic process (GO:0046886)2.58176606
113negative regulation of keratinocyte proliferation (GO:0010839)2.58089083
114negative regulation of chondrocyte differentiation (GO:0032331)2.57908129
115regulation of keratinocyte proliferation (GO:0010837)2.57207679
116establishment or maintenance of bipolar cell polarity (GO:0061245)2.56767385
117establishment or maintenance of apical/basal cell polarity (GO:0035088)2.56767385
118receptor recycling (GO:0001881)2.56475640
119dorsal/ventral neural tube patterning (GO:0021904)2.56075089
120regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.55864585
121regulation of RNA export from nucleus (GO:0046831)2.55329569
122regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.54615953
123genitalia morphogenesis (GO:0035112)2.54482341
124translational termination (GO:0006415)2.53907836
125primitive streak formation (GO:0090009)2.53808714
126prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.53270369
127stem cell proliferation (GO:0072089)2.52552706
128vitamin transmembrane transport (GO:0035461)2.52353658
129establishment of nucleus localization (GO:0040023)2.50413335
130endocardial cushion morphogenesis (GO:0003203)2.50177238
131intestinal cholesterol absorption (GO:0030299)2.48976185
132branching involved in salivary gland morphogenesis (GO:0060445)2.48343167
133embryonic axis specification (GO:0000578)2.48320302
134post-anal tail morphogenesis (GO:0036342)2.48035112
135midbrain development (GO:0030901)2.47573080
136positive regulation of insulin receptor signaling pathway (GO:0046628)2.47389847
137appendage morphogenesis (GO:0035107)2.46670728
138limb morphogenesis (GO:0035108)2.46670728
139anatomical structure regression (GO:0060033)2.46655124
140* regulation of catenin import into nucleus (GO:0035412)2.45823450
141regulation of transforming growth factor beta2 production (GO:0032909)2.45711656
142male genitalia development (GO:0030539)2.44746616
143glucocorticoid receptor signaling pathway (GO:0042921)2.44571102
144somatic stem cell division (GO:0048103)2.43677310
145negative regulation of axon guidance (GO:1902668)2.43549848
146embryonic camera-type eye morphogenesis (GO:0048596)2.43542404
147ephrin receptor signaling pathway (GO:0048013)2.43021855
148mesenchyme morphogenesis (GO:0072132)2.42730236
149NLS-bearing protein import into nucleus (GO:0006607)2.42591741
150embryonic pattern specification (GO:0009880)2.42222858
151organ induction (GO:0001759)2.42206140
152renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.42165639
153canonical Wnt signaling pathway (GO:0060070)2.41414253
154regulation of posttranscriptional gene silencing (GO:0060147)2.40729529
155regulation of gene silencing by miRNA (GO:0060964)2.40729529
156regulation of gene silencing by RNA (GO:0060966)2.40729529
157glomerular epithelial cell development (GO:0072310)2.40462298
158inner ear receptor cell differentiation (GO:0060113)2.40059270
159positive regulation of Wnt signaling pathway (GO:0030177)2.39937236
160heterochromatin organization (GO:0070828)2.39533198
161embryonic process involved in female pregnancy (GO:0060136)2.39317274
162RNA localization (GO:0006403)2.38111621
163L-serine transport (GO:0015825)2.36561052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.70381708
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.76234719
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.17929171
4E2F7_22180533_ChIP-Seq_HELA_Human3.01284665
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.59510562
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.58915954
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.50763891
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49180929
9* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.48952458
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33548875
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.24129886
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.23952178
13ZNF263_19887448_ChIP-Seq_K562_Human2.23281099
14* FOXA2_19822575_ChIP-Seq_HepG2_Human2.15822850
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.10600419
16ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09204286
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07820638
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04412217
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.02769931
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.02769931
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.02769931
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92632952
23* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86444777
24* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.85810322
25* CDX2_20551321_ChIP-Seq_CACO-2_Human1.85223789
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84548751
27CLOCK_20551151_ChIP-Seq_293T_Human1.83356724
28* ISL1_27105846_Chip-Seq_CPCs_Mouse1.81190399
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78358018
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76840257
31* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73156030
32* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.72654332
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71531407
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.70817519
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70508012
36* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68794909
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67866867
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66027172
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66027172
40FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.65331892
41* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64627128
42* RING1B_27294783_Chip-Seq_NPCs_Mouse1.61520438
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59143481
44POU5F1_16518401_ChIP-PET_MESCs_Mouse1.57592223
45* KDM2B_26808549_Chip-Seq_K562_Human1.57123797
46TP53_20018659_ChIP-ChIP_R1E_Mouse1.54036084
47* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51992915
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.49614774
49* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.48626781
50* RNF2_27304074_Chip-Seq_ESCs_Mouse1.44555217
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44285514
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44030324
53* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.41512580
54* EZH2_27304074_Chip-Seq_ESCs_Mouse1.41179065
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40759648
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.38334729
57* RUNX1_27514584_Chip-Seq_MCF-7_Human1.35516998
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35371859
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35338018
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.34002461
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33852521
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.33543074
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33385867
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32778623
65HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32034558
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.30334082
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30018498
68* PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29045292
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28872433
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28351919
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.28266805
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27949590
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27825424
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27563046
75CREB1_26743006_Chip-Seq_LNCaP_Human1.27178113
76RACK7_27058665_Chip-Seq_MCF-7_Human1.26981147
77* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25549941
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25480428
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25110630
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.25102948
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24080965
82GATA6_25053715_ChIP-Seq_YYC3_Human1.21913729
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.21073805
84EZH2_22144423_ChIP-Seq_EOC_Human1.19757349
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.19496632
86PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17671513
87GATA4_25053715_ChIP-Seq_YYC3_Human1.17448910
88* KDM2B_26808549_Chip-Seq_DND41_Human1.17239317
89* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16894535
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15845997
91* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15517438
92* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14140440
93AHR_22903824_ChIP-Seq_MCF-7_Human1.13595140
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12253263
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12236935
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11383604
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.10554822
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10334167
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09982830
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09444663
101* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08491197
102* EP300_21415370_ChIP-Seq_HL-1_Mouse1.07255095
103* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05546927
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.05324764
105AR_21909140_ChIP-Seq_LNCAP_Human1.05139940
106KAP1_27257070_Chip-Seq_ESCs_Mouse1.03479091
107* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03466498
108* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03201155
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02343794
110* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01880837
111* FOXO3_23340844_ChIP-Seq_DLD1_Human1.01664530
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01482471
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.99910461
114ESR1_21235772_ChIP-Seq_MCF-7_Human0.99344670
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99103313
116ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98841327
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98681136
118* KLF5_25053715_ChIP-Seq_YYC3_Human0.98596220
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97946385
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97519403
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97275990
122* TCF7_22412390_ChIP-Seq_EML_Mouse0.97264097
123GATA1_22025678_ChIP-Seq_K562_Human0.96643398
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.96294994
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94904779
126EZH2_27294783_Chip-Seq_ESCs_Mouse0.94614507
127TRIM28_21343339_ChIP-Seq_HEK293_Human0.94318224
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94284696
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93635974
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93553304
131* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93522904
132ARNT_22903824_ChIP-Seq_MCF-7_Human0.93360084
133SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92813499
134* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92339882
135HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91957511
136* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91716023
137NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90834312
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90271551
139* NANOG_16153702_ChIP-ChIP_HESCs_Human0.89812219
140* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87988161
141RXR_22158963_ChIP-Seq_LIVER_Mouse0.87930850
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.87155824
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86290810
144RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86108089
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84815986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology4.25157056
2MP0010030_abnormal_orbit_morphology3.68573439
3MP0001986_abnormal_taste_sensitivity3.35123160
4MP0009053_abnormal_anal_canal3.15040413
5MP0010234_abnormal_vibrissa_follicle2.97790845
6MP0000566_synostosis2.78636893
7MP0000462_abnormal_digestive_system2.47494765
8MP0002249_abnormal_larynx_morphology2.37970393
9MP0004264_abnormal_extraembryonic_tissu2.30238016
10MP0005187_abnormal_penis_morphology2.25228400
11MP0005248_abnormal_Harderian_gland2.24712130
12MP0002653_abnormal_ependyma_morphology2.22825095
13MP0003705_abnormal_hypodermis_morpholog2.22640551
14MP0003119_abnormal_digestive_system2.19234728
15MP0003283_abnormal_digestive_organ2.13909388
16MP0003123_paternal_imprinting1.97632022
17MP0003937_abnormal_limbs/digits/tail_de1.92757882
18MP0005076_abnormal_cell_differentiation1.92041464
19MP0003385_abnormal_body_wall1.84308182
20MP0003890_abnormal_embryonic-extraembry1.81748803
21MP0000579_abnormal_nail_morphology1.81333150
22MP0001849_ear_inflammation1.80674412
23MP0000762_abnormal_tongue_morphology1.77201678
24MP0009250_abnormal_appendicular_skeleto1.76178854
25MP0003941_abnormal_skin_development1.74371367
26MP0003755_abnormal_palate_morphology1.69289675
27MP0003942_abnormal_urinary_system1.67382014
28MP0000049_abnormal_middle_ear1.65967192
29MP0010352_gastrointestinal_tract_polyps1.63294857
30MP0002932_abnormal_joint_morphology1.62930679
31MP0002098_abnormal_vibrissa_morphology1.61612531
32MP0003121_genomic_imprinting1.59322478
33MP0010678_abnormal_skin_adnexa1.57473723
34MP0003122_maternal_imprinting1.56891977
35MP0003315_abnormal_perineum_morphology1.55981725
36MP0003935_abnormal_craniofacial_develop1.55277247
37MP0000534_abnormal_ureter_morphology1.54026823
38MP0003938_abnormal_ear_development1.53377356
39MP0002254_reproductive_system_inflammat1.53266799
40MP0002089_abnormal_postnatal_growth/wei1.51407418
41MP0003115_abnormal_respiratory_system1.51261515
42MP0003567_abnormal_fetal_cardiomyocyte1.49965788
43MP0003787_abnormal_imprinting1.49424582
44MP0002084_abnormal_developmental_patter1.46745480
45* MP0002116_abnormal_craniofacial_bone1.46021666
46MP0000428_abnormal_craniofacial_morphol1.45733004
47MP0002085_abnormal_embryonic_tissue1.42796669
48MP0000383_abnormal_hair_follicle1.40721023
49MP0002796_impaired_skin_barrier1.39969257
50MP0009379_abnormal_foot_pigmentation1.39953401
51MP0002233_abnormal_nose_morphology1.39247192
52MP0005367_renal/urinary_system_phenotyp1.36058580
53MP0000516_abnormal_urinary_system1.36058580
54* MP0000432_abnormal_head_morphology1.35207538
55MP0000467_abnormal_esophagus_morphology1.33593706
56MP0002111_abnormal_tail_morphology1.31997400
57MP0002938_white_spotting1.29843645
58MP0002282_abnormal_trachea_morphology1.29334389
59MP0008961_abnormal_basal_metabolism1.28836727
60MP0003693_abnormal_embryo_hatching1.26872370
61MP0002009_preneoplasia1.25392461
62MP0005377_hearing/vestibular/ear_phenot1.22319385
63MP0003878_abnormal_ear_physiology1.22319385
64MP0000647_abnormal_sebaceous_gland1.21101982
65MP0000733_abnormal_muscle_development1.20901982
66MP0003861_abnormal_nervous_system1.16917224
67MP0001346_abnormal_lacrimal_gland1.13793611
68MP0001293_anophthalmia1.13457942
69MP0002234_abnormal_pharynx_morphology1.13444343
70MP0004185_abnormal_adipocyte_glucose1.13140431
71MP0003943_abnormal_hepatobiliary_system1.12359215
72MP0003136_yellow_coat_color1.11102925
73MP0001340_abnormal_eyelid_morphology1.10147674
74MP0003453_abnormal_keratinocyte_physiol1.09838718
75MP0004197_abnormal_fetal_growth/weight/1.07604289
76MP0004858_abnormal_nervous_system1.07383755
77MP0000613_abnormal_salivary_gland1.05987296
78MP0005409_darkened_coat_color1.05009851
79MP0005380_embryogenesis_phenotype1.04261982
80MP0001672_abnormal_embryogenesis/_devel1.04261982
81MP0009672_abnormal_birth_weight1.04084408
82MP0004272_abnormal_basement_membrane1.03278481
83MP0001286_abnormal_eye_development1.01005710
84MP0002109_abnormal_limb_morphology1.00708227
85MP0001666_abnormal_nutrient_absorption1.00180592
86MP0000678_abnormal_parathyroid_gland0.99718949
87MP0002114_abnormal_axial_skeleton0.98779142
88MP0002086_abnormal_extraembryonic_tissu0.98046638
89MP0000778_abnormal_nervous_system0.94691950
90MP0005499_abnormal_olfactory_system0.94300794
91MP0005394_taste/olfaction_phenotype0.94300794
92MP0001697_abnormal_embryo_size0.93129981
93MP0004957_abnormal_blastocyst_morpholog0.93098187
94MP0002697_abnormal_eye_size0.93020070
95MP0004742_abnormal_vestibular_system0.92592464
96MP0001915_intracranial_hemorrhage0.90376816
97MP0000377_abnormal_hair_follicle0.88835146
98* MP0002092_abnormal_eye_morphology0.88480857
99MP0005365_abnormal_bile_salt0.87280267
100MP0005508_abnormal_skeleton_morphology0.86975813
101MP0009384_cardiac_valve_regurgitation0.85341774
102MP0002088_abnormal_embryonic_growth/wei0.84965959
103MP0000163_abnormal_cartilage_morphology0.84891837
104MP0001270_distended_abdomen0.84503661
105MP0003984_embryonic_growth_retardation0.83297944
106MP0002060_abnormal_skin_morphology0.82045945
107MP0008789_abnormal_olfactory_epithelium0.81904409
108MP0001730_embryonic_growth_arrest0.81473519
109MP0009703_decreased_birth_body0.81114908
110MP0001216_abnormal_epidermal_layer0.80654104
111MP0005408_hypopigmentation0.80503630
112MP0003936_abnormal_reproductive_system0.79834683
113MP0001299_abnormal_eye_distance/0.79450674
114MP0005257_abnormal_intraocular_pressure0.78517523
115MP0005501_abnormal_skin_physiology0.77176091
116MP0002108_abnormal_muscle_morphology0.77096417
117MP0008057_abnormal_DNA_replication0.76874675
118MP0002925_abnormal_cardiovascular_devel0.76511609
119MP0000477_abnormal_intestine_morphology0.76286856
120MP0002081_perinatal_lethality0.75738631
121MP0002896_abnormal_bone_mineralization0.75573659
122MP0003111_abnormal_nucleus_morphology0.75496057
123MP0002177_abnormal_outer_ear0.74995420
124MP0001324_abnormal_eye_pigmentation0.74715038
125MP0009780_abnormal_chondrocyte_physiolo0.74338749
126MP0010329_abnormal_lipoprotein_level0.72136284

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.86889526
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.86889526
3Deep venous thrombosis (HP:0002625)3.79648296
4Abnormality of the 4th metacarpal (HP:0010012)3.39413545
5Renal duplication (HP:0000075)3.27186351
6Small epiphyses (HP:0010585)3.09499450
7Abnormality of the parietal bone (HP:0002696)3.07184397
8Milia (HP:0001056)2.94336514
9Broad palm (HP:0001169)2.93316212
10Insomnia (HP:0100785)2.89629762
11Abnormal tarsal ossification (HP:0008369)2.88888020
12Bilateral microphthalmos (HP:0007633)2.88495665
13Premature skin wrinkling (HP:0100678)2.86560178
14Shallow orbits (HP:0000586)2.86535182
15Midline defect of the nose (HP:0004122)2.84141900
16Trigonocephaly (HP:0000243)2.83673247
17Turricephaly (HP:0000262)2.82458746
18Abnormality of the aortic arch (HP:0012303)2.81981173
19Hypoplastic labia majora (HP:0000059)2.81338965
20Abnormality of the distal phalanx of the thumb (HP:0009617)2.78140151
21Bronchomalacia (HP:0002780)2.72248580
22Coronal craniosynostosis (HP:0004440)2.71652595
23Shawl scrotum (HP:0000049)2.70807740
24Broad alveolar ridges (HP:0000187)2.70302571
25Short phalanx of the thumb (HP:0009660)2.67545843
26Abnormality of the phalanges of the hallux (HP:0010057)2.63946309
27Rib fusion (HP:0000902)2.61882979
28Partial duplication of thumb phalanx (HP:0009944)2.60231511
29Flat acetabular roof (HP:0003180)2.56891926
30Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.56587120
31Abnormality of the labia majora (HP:0012881)2.51710837
32Abnormality of the lacrimal duct (HP:0011481)2.51153388
33Abnormality of carpal bone ossification (HP:0006257)2.51108378
34Bifid scrotum (HP:0000048)2.50939975
35Prolonged partial thromboplastin time (HP:0003645)2.50928231
36Ankyloglossia (HP:0010296)2.50671647
37Microglossia (HP:0000171)2.50669881
38Partial duplication of the phalanx of hand (HP:0009999)2.50598337
39Supernumerary ribs (HP:0005815)2.46575602
40Broad toe (HP:0001837)2.46415524
41Vaginal fistula (HP:0004320)2.45699089
42Broad thumb (HP:0011304)2.42683960
43Absent epiphyses (HP:0010577)2.40882175
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40882175
45High anterior hairline (HP:0009890)2.38784534
46Irregular epiphyses (HP:0010582)2.36735594
47Choanal stenosis (HP:0000452)2.36411321
48Neoplasm of the heart (HP:0100544)2.36080521
49Anophthalmia (HP:0000528)2.35688334
50Neonatal short-limb short stature (HP:0008921)2.35132766
51Myelomeningocele (HP:0002475)2.33765603
52Hypoplasia of the capital femoral epiphysis (HP:0003090)2.32931726
53Abnormality of the pubic bones (HP:0003172)2.32572025
54Urethral obstruction (HP:0000796)2.32173336
55Abnormality of the diencephalon (HP:0010662)2.30907053
56Rectal prolapse (HP:0002035)2.28425478
57Concave nail (HP:0001598)2.27243430
58Volvulus (HP:0002580)2.26704093
59Esophageal atresia (HP:0002032)2.26137510
60Alacrima (HP:0000522)2.23093784
61Abnormal foot bone ossification (HP:0010675)2.22134303
62Epiphyseal dysplasia (HP:0002656)2.22078338
63Annular pancreas (HP:0001734)2.22008546
64Asymmetry of the thorax (HP:0001555)2.21440056
6511 pairs of ribs (HP:0000878)2.21179189
66Pili torti (HP:0003777)2.20183555
67Abnormality of the gastric mucosa (HP:0004295)2.19727875
68Lip pit (HP:0100267)2.17601541
69Limited elbow extension (HP:0001377)2.16492954
70Short 5th finger (HP:0009237)2.16023070
71Pterygium (HP:0001059)2.14230144
72Short 1st metacarpal (HP:0010034)2.13994152
73Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.13994152
74Abnormal ossification of hand bones (HP:0005921)2.13773723
75Anal stenosis (HP:0002025)2.12912585
76Arnold-Chiari malformation (HP:0002308)2.12769924
77Short middle phalanx of finger (HP:0005819)2.12369320
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10780031
79Abnormal hand bone ossification (HP:0010660)2.10528770
80Supernumerary bones of the axial skeleton (HP:0009144)2.09249870
81Hepatoblastoma (HP:0002884)2.08854091
82Wide cranial sutures (HP:0010537)2.08483562
83Broad hallux (HP:0010055)2.08379485
84Preaxial foot polydactyly (HP:0001841)2.08361103
85Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.08042420
86Woolly hair (HP:0002224)2.03668954
87Abnormality of the 1st metacarpal (HP:0010009)2.03502654
88Nephroblastoma (Wilms tumor) (HP:0002667)2.03397291
89Ulnar bowing (HP:0003031)2.03118422
90Right ventricular cardiomyopathy (HP:0011663)2.03060245
91Abnormality of the labia minora (HP:0012880)2.02056927
92Duplication of thumb phalanx (HP:0009942)2.00380714
93Hyperacusis (HP:0010780)2.00276605
94Pseudobulbar signs (HP:0002200)1.99956432
95Renovascular hypertension (HP:0100817)1.98923047
96Astrocytoma (HP:0009592)1.98762067
97Abnormality of the astrocytes (HP:0100707)1.98762067
98Sparse lateral eyebrow (HP:0005338)1.98593854
99Abnormality of the 2nd finger (HP:0004100)1.98034830
100Widely patent fontanelles and sutures (HP:0004492)1.97431488
101Cutaneous finger syndactyly (HP:0010554)1.96378247
102Neoplasm of striated muscle (HP:0009728)1.95338835
103Heterotopia (HP:0002282)1.94894188
104Hypercholesterolemia (HP:0003124)1.94799396
105Down-sloping shoulders (HP:0200021)1.94400467
106Colon cancer (HP:0003003)1.93660542
107Increased nuchal translucency (HP:0010880)1.90655509
108Aplasia cutis congenita (HP:0001057)1.88965191
109Abnormal number of incisors (HP:0011064)1.88744170
110Embryonal renal neoplasm (HP:0011794)1.86217786
111Deviation of the hallux (HP:0010051)1.84933607
112Atrophic scars (HP:0001075)1.84915783
113Abnormality of oral frenula (HP:0000190)1.84529167
114Abnormality of the nasal septum (HP:0000419)1.84152504
115Subacute progressive viral hepatitis (HP:0006572)1.83713790
116Overriding aorta (HP:0002623)1.83613376
117Short middle phalanx of the 5th finger (HP:0004220)1.82954610
118Periodontitis (HP:0000704)1.81780942
119Labial hypoplasia (HP:0000066)1.80980728
120Nasolacrimal duct obstruction (HP:0000579)1.80545563
121Short humerus (HP:0005792)1.79972429
122Medulloblastoma (HP:0002885)1.78886574
123Abnormality of the nasolacrimal system (HP:0000614)1.78732447
124Absent eyebrow (HP:0002223)1.78203545
125Hypotrichosis (HP:0001006)1.77760005
126Rectovaginal fistula (HP:0000143)1.77255646
127Rectal fistula (HP:0100590)1.77255646
128Ridged nail (HP:0001807)1.75735828
129Intestinal fistula (HP:0100819)1.75420444
130Broad phalanges of the hand (HP:0009768)1.75415424
131Ureteral stenosis (HP:0000071)1.74527213
132Ependymoma (HP:0002888)1.74412877
133Patellar dislocation (HP:0002999)1.73969785
134Skin tags (HP:0010609)1.73829516
135Missing ribs (HP:0000921)1.73828617
136Narrow palate (HP:0000189)1.73822317
137Aplasia involving bones of the upper limbs (HP:0009823)1.73512119
138Aplasia of the phalanges of the hand (HP:0009802)1.73512119
139Aplasia involving bones of the extremities (HP:0009825)1.73512119
140Midface retrusion (HP:0011800)1.73280448
141Elfin facies (HP:0004428)1.73226551
142Proximal placement of thumb (HP:0009623)1.73008085
143Glioma (HP:0009733)1.72862776
144Oligodactyly (HP:0012165)1.72738966
145Cutaneous syndactyly (HP:0012725)1.72087231
146Vesicoureteral reflux (HP:0000076)1.71644273
147Neoplasm of the oral cavity (HP:0100649)1.71565878
148Broad metatarsal (HP:0001783)1.71352374
149Synostosis of carpal bones (HP:0005048)1.71244936
150Decreased lacrimation (HP:0000633)1.70670643
151Anteriorly placed anus (HP:0001545)1.70412334
152Omphalocele (HP:0001539)1.70164489
153Hemivertebrae (HP:0002937)1.69271421
154Broad finger (HP:0001500)1.69242632
155Hallux valgus (HP:0001822)1.67970276
156Aplasia/hypoplasia of the humerus (HP:0006507)1.67949090
157Vertebral arch anomaly (HP:0008438)1.67100682
158Wide nose (HP:0000445)1.66825827
159Bicornuate uterus (HP:0000813)1.66044856
160Deviation of the thumb (HP:0009603)1.65732643
161Atresia of the external auditory canal (HP:0000413)1.65240332
162Abnormal lung lobation (HP:0002101)1.65102219
163Chorioretinal atrophy (HP:0000533)1.64571851
164Scrotal hypoplasia (HP:0000046)1.62055462
165Papillary thyroid carcinoma (HP:0002895)1.61106738
166Wide anterior fontanel (HP:0000260)1.60852388
167Malignant hyperthermia (HP:0002047)1.60235853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.75107676
2CDK123.71791853
3LATS23.05164480
4EPHB22.96310218
5ICK2.87731016
6STK392.86824963
7DDR22.67566402
8TYRO32.65088617
9LMTK22.37869947
10EPHA22.23501253
11RIPK12.23438892
12MAP3K102.18954978
13STK242.06181771
14EEF2K2.02825993
15AKT32.01256665
16PDGFRA1.99341789
17WNK41.82370270
18TRIB31.65545159
19ERBB21.64856370
20SMG11.61547150
21KSR11.58582862
22FGFR21.50093047
23DMPK1.48879014
24TAOK11.45991025
25PRKD31.37238623
26STK38L1.33567386
27MAP3K91.32066292
28FRK1.31784009
29NUAK11.28314764
30FGFR11.26958976
31TTK1.25408119
32STK31.22366765
33SIK11.21664185
34MTOR1.21016928
35FER1.20739651
36BRD41.19133944
37BMX1.17966153
38STK381.14961389
39PTK61.13586308
40PBK1.12905012
41CDK71.10456230
42RPS6KB21.08763748
43SRPK11.07742920
44CDC71.01453960
45PTK20.99411412
46OXSR10.94891839
47MAPK150.94754020
48MST1R0.94522361
49CDK60.94094498
50NEK20.91909765
51MAP3K60.89974837
52PRKD20.89816794
53CAMK1G0.89232696
54NME10.88162739
55PASK0.83502026
56NTRK20.83047335
57CAMK1D0.82827341
58MAP3K70.82775599
59MELK0.82611221
60PDGFRB0.82275633
61NLK0.81939286
62DYRK1B0.72473594
63KSR20.71898258
64PIK3CA0.70384266
65PAK40.70246394
66CSNK1A1L0.69526972
67STK100.69011785
68ALK0.68999130
69MAP2K20.68504700
70MARK20.67848067
71CSNK1E0.67786867
72MKNK10.66537720
73CHEK20.66379027
74RET0.65403352
75CHEK10.64633356
76EPHA40.64545370
77CASK0.64482645
78PAK60.63746332
79MKNK20.61338978
80GRK60.61042923
81MAP3K20.59114345
82WNK10.58923142
83ERBB40.58601428
84CDK40.58391554
85TNIK0.58368721
86CDK90.58253354
87MAP3K110.56222274
88CSNK1G10.55996524
89CDC42BPA0.55949346
90RPS6KA40.55397624
91YES10.54805802
92PAK30.54794700
93ZAK0.54040150
94RPS6KB10.54006583
95UHMK10.53886786
96AURKB0.51714638
97CAMK40.51171403
98AKT20.51003217
99PRKCI0.50525459
100MET0.48972465
101NEK90.48882506
102WEE10.48623181
103SGK2230.48564724
104SGK4940.48564724
105PAK20.48148618
106FGFR40.47806552
107EPHA30.47607334
108CDK20.47509296
109TAF10.47435150
110MAP2K40.46303791
111STK110.46163161
112PRKG20.45959323
113NEK60.45170101
114FGFR30.42824810
115MAP3K40.41603276
116PRKAA10.41063011
117BCR0.41059278
118PLK10.40855752
119PKN20.39628225
120RPS6KA10.39472105
121CDK10.38825946
122MAPK100.38468946
123CSNK1G20.38031079
124PRKAA20.37935105
125CSNK1D0.37224127
126GSK3B0.37202139
127MAPK140.36475146
128MAP3K80.35327937
129DYRK1A0.34993734
130SGK20.33939291
131PHKG20.32588382
132PHKG10.32588382
133TTN0.32123305
134SGK10.30469258
135NTRK30.30409126
136SGK30.28730203
137BRSK20.27112723
138ATM0.26609641

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052174.08972233
2Hedgehog signaling pathway_Homo sapiens_hsa043403.24720015
3* Hippo signaling pathway_Homo sapiens_hsa043902.96533478
4Nitrogen metabolism_Homo sapiens_hsa009102.53196237
5Adherens junction_Homo sapiens_hsa045202.47704653
6* Wnt signaling pathway_Homo sapiens_hsa043102.30790835
7* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.21599588
8Notch signaling pathway_Homo sapiens_hsa043301.93243801
9Complement and coagulation cascades_Homo sapiens_hsa046101.89585734
10Melanogenesis_Homo sapiens_hsa049161.85485805
11TGF-beta signaling pathway_Homo sapiens_hsa043501.71670810
12Ribosome_Homo sapiens_hsa030101.68134400
13Axon guidance_Homo sapiens_hsa043601.66744773
14Lysine degradation_Homo sapiens_hsa003101.64894299
15Dorso-ventral axis formation_Homo sapiens_hsa043201.62904383
16Tight junction_Homo sapiens_hsa045301.62764826
17Proteoglycans in cancer_Homo sapiens_hsa052051.59891703
18MicroRNAs in cancer_Homo sapiens_hsa052061.54621563
19* Endometrial cancer_Homo sapiens_hsa052131.46697600
20mTOR signaling pathway_Homo sapiens_hsa041501.44961766
21Thyroid cancer_Homo sapiens_hsa052161.39502005
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39489188
23Steroid biosynthesis_Homo sapiens_hsa001001.37517592
24Bladder cancer_Homo sapiens_hsa052191.36160558
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35994988
26Fat digestion and absorption_Homo sapiens_hsa049751.32811832
27Vitamin B6 metabolism_Homo sapiens_hsa007501.32636095
28* Colorectal cancer_Homo sapiens_hsa052101.32034839
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28391995
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28254070
31mRNA surveillance pathway_Homo sapiens_hsa030151.17862921
32GnRH signaling pathway_Homo sapiens_hsa049121.17226625
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16639968
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15748517
35Protein digestion and absorption_Homo sapiens_hsa049741.15089516
36* Pathways in cancer_Homo sapiens_hsa052001.14866663
37N-Glycan biosynthesis_Homo sapiens_hsa005101.12379418
38Bile secretion_Homo sapiens_hsa049761.10909795
39Small cell lung cancer_Homo sapiens_hsa052221.09155487
40Histidine metabolism_Homo sapiens_hsa003401.08679227
41Estrogen signaling pathway_Homo sapiens_hsa049151.08455522
42ErbB signaling pathway_Homo sapiens_hsa040121.06742604
43Systemic lupus erythematosus_Homo sapiens_hsa053221.06266015
44ECM-receptor interaction_Homo sapiens_hsa045121.04951939
45Vitamin digestion and absorption_Homo sapiens_hsa049771.04660318
46Choline metabolism in cancer_Homo sapiens_hsa052311.04436381
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02482531
48Oocyte meiosis_Homo sapiens_hsa041141.02130447
49Fatty acid biosynthesis_Homo sapiens_hsa000611.01921923
50Alcoholism_Homo sapiens_hsa050341.01010145
51Gap junction_Homo sapiens_hsa045400.97475737
52PPAR signaling pathway_Homo sapiens_hsa033200.97139135
53Focal adhesion_Homo sapiens_hsa045100.96502636
54Rap1 signaling pathway_Homo sapiens_hsa040150.96454641
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96014861
56Prostate cancer_Homo sapiens_hsa052150.95001120
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93028267
58Chronic myeloid leukemia_Homo sapiens_hsa052200.92474051
59VEGF signaling pathway_Homo sapiens_hsa043700.90813239
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90772653
61Cell cycle_Homo sapiens_hsa041100.89875991
62Gastric acid secretion_Homo sapiens_hsa049710.89819265
63Glioma_Homo sapiens_hsa052140.89601453
64Fatty acid degradation_Homo sapiens_hsa000710.89564111
65HTLV-I infection_Homo sapiens_hsa051660.89476339
66Non-small cell lung cancer_Homo sapiens_hsa052230.88590701
67Pancreatic cancer_Homo sapiens_hsa052120.86484370
68Arginine and proline metabolism_Homo sapiens_hsa003300.84144123
69Circadian rhythm_Homo sapiens_hsa047100.82623737
70Renal cell carcinoma_Homo sapiens_hsa052110.80274647
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80086251
72Insulin signaling pathway_Homo sapiens_hsa049100.78331782
73AMPK signaling pathway_Homo sapiens_hsa041520.78218022
74Other glycan degradation_Homo sapiens_hsa005110.77961787
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77933181
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.76943390
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75644041
78Propanoate metabolism_Homo sapiens_hsa006400.75139591
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74374624
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74236109
81Renin secretion_Homo sapiens_hsa049240.73964973
82Biosynthesis of amino acids_Homo sapiens_hsa012300.73384340
83Thyroid hormone synthesis_Homo sapiens_hsa049180.72951474
84ABC transporters_Homo sapiens_hsa020100.72888745
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72559688
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72090009
87Glucagon signaling pathway_Homo sapiens_hsa049220.71490423
88Pyruvate metabolism_Homo sapiens_hsa006200.70745387
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70293385
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70219838
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68990474
92Starch and sucrose metabolism_Homo sapiens_hsa005000.68983039
93Mineral absorption_Homo sapiens_hsa049780.68419052
94Melanoma_Homo sapiens_hsa052180.67810995
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67282947
96Salivary secretion_Homo sapiens_hsa049700.67163011
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66835113
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66557175
99Arginine biosynthesis_Homo sapiens_hsa002200.65594377
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64340414
101Vibrio cholerae infection_Homo sapiens_hsa051100.64141095
102Long-term potentiation_Homo sapiens_hsa047200.63665155
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63256106
104cAMP signaling pathway_Homo sapiens_hsa040240.62646068
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61868135
106DNA replication_Homo sapiens_hsa030300.60357390
107Insulin secretion_Homo sapiens_hsa049110.60350528
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59695144
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59181501
110Fatty acid metabolism_Homo sapiens_hsa012120.58618556
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58567935
112Cocaine addiction_Homo sapiens_hsa050300.58499960
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.58135173
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57869835
115Mismatch repair_Homo sapiens_hsa034300.57366583
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.56673451
117Type II diabetes mellitus_Homo sapiens_hsa049300.54755947
118Glycerolipid metabolism_Homo sapiens_hsa005610.54301672
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.54025518
120MAPK signaling pathway_Homo sapiens_hsa040100.53832188
121Ovarian steroidogenesis_Homo sapiens_hsa049130.53309994
122Pancreatic secretion_Homo sapiens_hsa049720.52501519
123Inositol phosphate metabolism_Homo sapiens_hsa005620.52477019
124Nucleotide excision repair_Homo sapiens_hsa034200.52123566
125Amphetamine addiction_Homo sapiens_hsa050310.52075721
126Viral carcinogenesis_Homo sapiens_hsa052030.51665610
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51194737
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50792933
129Ras signaling pathway_Homo sapiens_hsa040140.50028736
130Oxytocin signaling pathway_Homo sapiens_hsa049210.49379106
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49373530
132RNA transport_Homo sapiens_hsa030130.48638170
133FoxO signaling pathway_Homo sapiens_hsa040680.47127938
134Viral myocarditis_Homo sapiens_hsa054160.46783082
135Prolactin signaling pathway_Homo sapiens_hsa049170.46773004
136Glutamatergic synapse_Homo sapiens_hsa047240.46700031
137Spliceosome_Homo sapiens_hsa030400.45422495
138Insulin resistance_Homo sapiens_hsa049310.45403191
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.45144273
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45040948
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.44552914
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44460469
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44320227
144Fructose and mannose metabolism_Homo sapiens_hsa000510.42507141

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »