AZI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.00271759
2doxorubicin metabolic process (GO:0044598)9.00271759
3daunorubicin metabolic process (GO:0044597)9.00271759
4aminoglycoside antibiotic metabolic process (GO:0030647)5.88124550
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.57923064
6hormone catabolic process (GO:0042447)4.53665373
7platelet dense granule organization (GO:0060155)4.40172441
8maintenance of protein location in nucleus (GO:0051457)4.25198206
9protein neddylation (GO:0045116)4.23359366
10positive regulation of mitochondrial fission (GO:0090141)4.17289236
11negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.13073654
12regulation of MHC class I biosynthetic process (GO:0045343)4.11564503
13negative regulation of cell cycle G2/M phase transition (GO:1902750)4.07279071
14cytidine deamination (GO:0009972)4.06443396
15cytidine metabolic process (GO:0046087)4.06443396
16cytidine catabolic process (GO:0006216)4.06443396
17retinal ganglion cell axon guidance (GO:0031290)3.98930049
18coenzyme catabolic process (GO:0009109)3.93257514
19protein localization to cilium (GO:0061512)3.92865263
20muscle organ morphogenesis (GO:0048644)3.92803684
21positive regulation of histone deacetylation (GO:0031065)3.86581100
22intraciliary transport (GO:0042073)3.82046890
23* interferon-gamma production (GO:0032609)3.77411727
24proteasome assembly (GO:0043248)3.75670651
25cellular modified amino acid catabolic process (GO:0042219)3.70512695
26pyrimidine ribonucleoside catabolic process (GO:0046133)3.69363629
27somite rostral/caudal axis specification (GO:0032525)3.66685586
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63814492
29mitochondrion distribution (GO:0048311)3.60393875
30pyrimidine nucleobase catabolic process (GO:0006208)3.57996030
31valine metabolic process (GO:0006573)3.57424936
32epoxygenase P450 pathway (GO:0019373)3.54247585
33positive regulation of protein deacetylation (GO:0090312)3.53870556
34negative regulation of membrane potential (GO:0045837)3.47681543
35hypotonic response (GO:0006971)3.46560627
36regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.44688381
37phagocytosis, recognition (GO:0006910)3.39712857
38nonmotile primary cilium assembly (GO:0035058)3.37586984
39presynaptic membrane assembly (GO:0097105)3.35011599
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34588573
41negative regulation of cell killing (GO:0031342)3.34588573
42sequestering of actin monomers (GO:0042989)3.34229134
43regulation of cilium movement (GO:0003352)3.30879138
44negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.28289849
45neural tube formation (GO:0001841)3.20672638
46histone H4-K8 acetylation (GO:0043982)3.20482150
47histone H4-K5 acetylation (GO:0043981)3.20482150
48cullin deneddylation (GO:0010388)3.20381717
49epithelial cilium movement (GO:0003351)3.17653080
50presynaptic membrane organization (GO:0097090)3.17646961
51cellular response to leptin stimulus (GO:0044320)3.15705404
52signal peptide processing (GO:0006465)3.11047967
53regulation of cAMP-dependent protein kinase activity (GO:2000479)3.06971933
54lipid particle organization (GO:0034389)3.05576755
55establishment of endothelial barrier (GO:0061028)2.99489795
56positive regulation of gamma-delta T cell activation (GO:0046645)2.98442770
57natural killer cell differentiation (GO:0001779)2.97661694
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96172342
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96172342
60maintenance of protein localization in organelle (GO:0072595)2.95917208
61regulation of apoptotic cell clearance (GO:2000425)2.95052585
62regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94847108
63respiratory chain complex IV assembly (GO:0008535)2.92471591
64regulation of telomere maintenance via telomerase (GO:0032210)2.92106313
65response to dietary excess (GO:0002021)2.91977254
66establishment of melanosome localization (GO:0032401)2.90949642
67phenol-containing compound catabolic process (GO:0019336)2.90905859
68cilium assembly (GO:0042384)2.90370338
69adaptation of signaling pathway (GO:0023058)2.90356117
70regulation of gamma-delta T cell differentiation (GO:0045586)2.89732765
71vascular smooth muscle contraction (GO:0014829)2.89674177
72nucleobase catabolic process (GO:0046113)2.89663125
73glomerulus development (GO:0032835)2.89239246
74Golgi transport vesicle coating (GO:0048200)2.88598750
75COPI coating of Golgi vesicle (GO:0048205)2.88598750
76keratinocyte development (GO:0003334)2.87833864
77negative regulation of epidermis development (GO:0045683)2.87154266
78protein deneddylation (GO:0000338)2.86531605
79inositol phosphate catabolic process (GO:0071545)2.86472323
80cilium organization (GO:0044782)2.86385484
81melanosome transport (GO:0032402)2.86135153
82axoneme assembly (GO:0035082)2.84407625
83negative regulation of axon guidance (GO:1902668)2.84252127
84dendritic spine morphogenesis (GO:0060997)2.84150738
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83333813
86neuron recognition (GO:0008038)2.81840312
87axonal fasciculation (GO:0007413)2.80705354
88primitive streak formation (GO:0090009)2.79566502
89short-term memory (GO:0007614)2.78494345
90cilium movement (GO:0003341)2.77557340
91positive regulation of protein autophosphorylation (GO:0031954)2.77170775
92cilium morphogenesis (GO:0060271)2.76202092
93sulfur amino acid catabolic process (GO:0000098)2.75612379
94positive regulation of macrophage cytokine production (GO:0060907)2.74314616
95protein targeting to Golgi (GO:0000042)2.74180376
96regulation of glucose import in response to insulin stimulus (GO:2001273)2.73143269
97establishment of pigment granule localization (GO:0051905)2.71318073
98establishment of protein localization to Golgi (GO:0072600)2.70898830
99olfactory bulb development (GO:0021772)2.70249562
100response to redox state (GO:0051775)2.70176170
101limb bud formation (GO:0060174)2.69372183
102inositol phosphate dephosphorylation (GO:0046855)2.68320801
103phosphorylated carbohydrate dephosphorylation (GO:0046838)2.68320801
104regulation of gamma-delta T cell activation (GO:0046643)2.67873018
105proline transport (GO:0015824)2.67252097
106ribonucleoprotein complex disassembly (GO:0032988)2.66214532
107pigment granule transport (GO:0051904)2.65830080
108histone H4-K16 acetylation (GO:0043984)2.65697490
109positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.64268793
110mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.64268793
111organelle disassembly (GO:1903008)2.63989659
112regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62496714
113regulation of response to osmotic stress (GO:0047484)2.61686229
114histone H4-K12 acetylation (GO:0043983)2.61036535
115glycosphingolipid biosynthetic process (GO:0006688)2.60945673
116DNA integration (GO:0015074)2.60895968
117magnesium ion transport (GO:0015693)2.58471936
118thyroid hormone generation (GO:0006590)2.57651138
119cornea development in camera-type eye (GO:0061303)2.56553916
120negative regulation of response to food (GO:0032096)2.54721863
121negative regulation of appetite (GO:0032099)2.54721863
122natural killer cell activation (GO:0030101)2.54509193
123regulation of alkaline phosphatase activity (GO:0010692)2.53845685
124negative regulation of bone resorption (GO:0045779)2.53788648
125melanosome localization (GO:0032400)2.52569433
126nucleoside transmembrane transport (GO:1901642)2.52122998
127JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52111453
128transepithelial transport (GO:0070633)2.51564212
129positive regulation of gluconeogenesis (GO:0045722)2.51235926
130protein complex biogenesis (GO:0070271)2.50301023
131cellular ketone body metabolic process (GO:0046950)2.50161133
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.48508821
133positive regulation of chemokine biosynthetic process (GO:0045080)2.48141498
134intra-Golgi vesicle-mediated transport (GO:0006891)2.47567806
135lipoprotein transport (GO:0042953)2.47505371
136regulation of Golgi to plasma membrane protein transport (GO:0042996)2.46361797
137regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45187463
138calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44661843
139positive regulation of synapse assembly (GO:0051965)2.43935411
140anterograde synaptic vesicle transport (GO:0048490)2.43757500
141membrane protein intracellular domain proteolysis (GO:0031293)2.43735179
142quinone metabolic process (GO:1901661)2.43051113
143progesterone metabolic process (GO:0042448)2.42957101
144cofactor catabolic process (GO:0051187)2.42872282
145positive regulation of defense response to virus by host (GO:0002230)2.42749902
146vasodilation (GO:0042311)2.42159588
147C-terminal protein lipidation (GO:0006501)2.41706727
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.41117775
149water-soluble vitamin biosynthetic process (GO:0042364)2.41098145
150hydrogen peroxide biosynthetic process (GO:0050665)2.40812423
151icosanoid secretion (GO:0032309)2.40264281
152arachidonic acid secretion (GO:0050482)2.40264281
153regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40044535
154neuron fate determination (GO:0048664)2.39521718
155regulation of isotype switching to IgG isotypes (GO:0048302)2.39411309
156ketone body metabolic process (GO:1902224)2.38861373
157positive regulation of gastrulation (GO:2000543)2.38453918
158keratan sulfate catabolic process (GO:0042340)2.38253693
159intestinal epithelial cell development (GO:0060576)2.38247038
160membrane budding (GO:0006900)2.38157550
161artery smooth muscle contraction (GO:0014824)2.37911377
162positive regulation of meiosis (GO:0045836)2.36992458
163resolution of meiotic recombination intermediates (GO:0000712)2.36885036
164regulation of interleukin-2 biosynthetic process (GO:0045076)2.36656548
165pigment granule localization (GO:0051875)2.36043597
166drug metabolic process (GO:0017144)2.34920788
167negative regulation of phagocytosis (GO:0050765)2.34297995
168response to leptin (GO:0044321)2.34015695
169cellular component assembly involved in morphogenesis (GO:0010927)2.33803638
170negative regulation of telomerase activity (GO:0051974)2.33431559
171negative regulation of signal transduction by p53 class mediator (GO:1901797)2.33293537
172regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.33258465
173GDP-mannose metabolic process (GO:0019673)2.32804232
174histone H2A acetylation (GO:0043968)2.31796413
175negative chemotaxis (GO:0050919)2.31668253
176response to interleukin-15 (GO:0070672)2.31390279
177histone H2A ubiquitination (GO:0033522)2.30563406
178regulation of feeding behavior (GO:0060259)2.30451799
179anterograde axon cargo transport (GO:0008089)2.30329363
180negative regulation of potassium ion transmembrane transport (GO:1901380)2.29865017
181C-terminal protein amino acid modification (GO:0018410)2.29698170
182Rap protein signal transduction (GO:0032486)2.29327951
183response to type I interferon (GO:0034340)2.28418329
184antigen processing and presentation of endogenous antigen (GO:0019883)2.28076235
185interferon-gamma-mediated signaling pathway (GO:0060333)2.27988769
186single strand break repair (GO:0000012)2.27452331
187determination of left/right symmetry (GO:0007368)2.27065873
188left/right axis specification (GO:0070986)2.26226939
189immunoglobulin mediated immune response (GO:0016064)2.26056806
190ganglion development (GO:0061548)2.25639427
191regulation of nuclear cell cycle DNA replication (GO:0033262)2.23696932
192determination of bilateral symmetry (GO:0009855)2.23213030
193response to peptidoglycan (GO:0032494)2.23029900
194DNA double-strand break processing (GO:0000729)2.22533576
195neurofilament cytoskeleton organization (GO:0060052)2.22104721
196mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.21706542
197type I interferon signaling pathway (GO:0060337)2.19567625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.04469168
2GATA1_22025678_ChIP-Seq_K562_Human4.85069853
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.47151058
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.47151058
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.47151058
6* IRF8_22096565_ChIP-ChIP_GC-B_Human3.91841552
7POU3F2_20337985_ChIP-ChIP_501MEL_Human3.33211155
8ZFP57_27257070_Chip-Seq_ESCs_Mouse3.05013173
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.96402599
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.74721753
11GBX2_23144817_ChIP-Seq_PC3_Human2.67202682
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.65543337
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.54366273
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51058547
15FUS_26573619_Chip-Seq_HEK293_Human2.47794739
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46791786
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42708706
18TAF15_26573619_Chip-Seq_HEK293_Human2.37517835
19EWS_26573619_Chip-Seq_HEK293_Human2.30335752
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24473864
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.23013968
22* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.21790390
23P300_19829295_ChIP-Seq_ESCs_Human2.18444795
24* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16825240
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.14063699
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12363160
27ZNF274_21170338_ChIP-Seq_K562_Hela2.06661546
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06394676
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05227551
30PIAS1_25552417_ChIP-Seq_VCAP_Human2.04319036
31* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93928015
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93128450
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90100145
34* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89842536
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.86357207
36SMAD4_21799915_ChIP-Seq_A2780_Human1.85344040
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83959182
38VDR_22108803_ChIP-Seq_LS180_Human1.83014849
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80405278
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.80202430
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80016283
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79354171
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78222784
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78099554
45SCL_19346495_ChIP-Seq_HPC-7_Human1.77427440
46NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75962141
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75941769
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74218262
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73262532
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.72824347
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.72241393
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.72081125
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69541051
54ELK1_19687146_ChIP-ChIP_HELA_Human1.69428087
55* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68808405
56EZH2_22144423_ChIP-Seq_EOC_Human1.67282078
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67014082
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66193310
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.64767413
60TCF7_22412390_ChIP-Seq_EML_Mouse1.64507629
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.61927452
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61643456
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61490481
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60492363
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59910775
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59370408
67NANOG_18555785_Chip-Seq_ESCs_Mouse1.59350534
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.58513421
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54705493
70CBP_20019798_ChIP-Seq_JUKART_Human1.54705493
71ER_23166858_ChIP-Seq_MCF-7_Human1.54030979
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53830168
73AR_25329375_ChIP-Seq_VCAP_Human1.52623660
74* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51602284
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.50727952
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50249139
77RNF2_27304074_Chip-Seq_NSC_Mouse1.47820529
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47458496
79MYB_26560356_Chip-Seq_TH1_Human1.47296283
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44973277
81MYB_26560356_Chip-Seq_TH2_Human1.44680420
82MYC_22102868_ChIP-Seq_BL_Human1.43771407
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42960945
84TP53_18474530_ChIP-ChIP_U2OS_Human1.41233528
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40662441
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40358118
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40358118
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.40034796
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39832511
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38211220
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37797995
92BCAT_22108803_ChIP-Seq_LS180_Human1.36513270
93SPI1_23127762_ChIP-Seq_K562_Human1.36317123
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.35555376
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34258128
96STAT3_23295773_ChIP-Seq_U87_Human1.34153113
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32717129
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32509144
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30807748
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.30589385
101P53_22387025_ChIP-Seq_ESCs_Mouse1.30304456
102* EST1_17652178_ChIP-ChIP_JURKAT_Human1.30007283
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29768153
104TAL1_26923725_Chip-Seq_HPCs_Mouse1.29586789
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28241484
106RUNX_20019798_ChIP-Seq_JUKART_Human1.27618230
107RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27000002
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25490158
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.25118141
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24719472
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.23872855
112TCF4_22108803_ChIP-Seq_LS180_Human1.21387634
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.20356014
114PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19882163
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18621284
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18590878
117GATA3_27048872_Chip-Seq_THYMUS_Human1.18261776
118* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16896486
119SOX2_19829295_ChIP-Seq_ESCs_Human1.16662207
120NANOG_19829295_ChIP-Seq_ESCs_Human1.16662207
121RUNX2_22187159_ChIP-Seq_PCA_Human1.15732824
122TCF4_23295773_ChIP-Seq_U87_Human1.15431659
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15295604
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.14762371
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.14584975
126JUN_21703547_ChIP-Seq_K562_Human1.14262754
127SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13565282
128BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12951082
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.11785786
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11332796
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11265703
132EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11078469
133* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10962989
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.10898425
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.10692495
136NOTCH1_21737748_ChIP-Seq_TLL_Human1.10591872
137MAF_26560356_Chip-Seq_TH1_Human1.09253925
138E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08914018
139CJUN_26792858_Chip-Seq_BT549_Human1.07643216
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07184155
141NCOR1_26117541_ChIP-Seq_K562_Human1.06561710
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06318465
143TRIM28_21343339_ChIP-Seq_HEK293_Human1.06223324
144POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05747893
145SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05305293
146NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05190639
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05151923
148TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05139803
149CDX2_22108803_ChIP-Seq_LS180_Human1.04949672
150HTT_18923047_ChIP-ChIP_STHdh_Human1.04763172
151EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04599481
152STAT3_18555785_Chip-Seq_ESCs_Mouse1.04106641
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03329255
154TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02871475
155GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02694332
156EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01064632
157STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00099472
158ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99932086
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99753532
160UTX_26944678_Chip-Seq_JUKART_Human0.98148548
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97829982
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97251388
163NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96883117
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92460956
165ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92442242
166WT1_19549856_ChIP-ChIP_CCG9911_Human0.91182796
167LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91104553
168IRF1_19129219_ChIP-ChIP_H3396_Human0.90265767
169ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89706049
170NANOG_16518401_ChIP-PET_MESCs_Mouse0.88178549
171GATA6_25053715_ChIP-Seq_YYC3_Human0.87653953
172IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87207584
173E2F1_17053090_ChIP-ChIP_MCF-7_Human0.87125588
174NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87048443
175SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85404403
176HOXB7_26014856_ChIP-Seq_BT474_Human0.84824859
177KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82205973
178CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80835978
179GATA2_19941826_ChIP-Seq_K562_Human0.80268344
180GATA3_26560356_Chip-Seq_TH2_Human0.79174413
181POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79146140
182NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78240475
183* SPI1_23547873_ChIP-Seq_NB4_Human0.77079079
184TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76711242
185SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75476616
186SMAD_19615063_ChIP-ChIP_OVARY_Human0.75045605
187TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74586141
188CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73028410
189PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72946664
190GATA4_25053715_ChIP-Seq_YYC3_Human0.70424017
191* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.69914040
192SOX2_27498859_Chip-Seq_STOMACH_Mouse0.69397502
193* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.69230407
194GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67206239
195PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.67147379
196IGF1R_20145208_ChIP-Seq_DFB_Human0.67145259
197TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.66545940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.49448395
2MP0003880_abnormal_central_pattern4.05093851
3MP0004264_abnormal_extraembryonic_tissu4.01707304
4MP0003011_delayed_dark_adaptation3.25215424
5MP0002254_reproductive_system_inflammat3.23845571
6MP0006072_abnormal_retinal_apoptosis2.52821022
7MP0004858_abnormal_nervous_system2.50597533
8MP0008961_abnormal_basal_metabolism2.37988431
9MP0008877_abnormal_DNA_methylation2.37044390
10MP0002332_abnormal_exercise_endurance2.34670231
11MP0003890_abnormal_embryonic-extraembry2.33870754
12MP0003436_decreased_susceptibility_to2.33469533
13MP0006082_CNS_inflammation2.33131312
14MP0002139_abnormal_hepatobiliary_system2.32178494
15MP0005360_urolithiasis2.27991271
16MP0005253_abnormal_eye_physiology2.25398525
17MP0000372_irregular_coat_pigmentation2.22300070
18MP0009046_muscle_twitch2.19315213
19MP0005503_abnormal_tendon_morphology2.17017638
20MP0002277_abnormal_respiratory_mucosa2.16671687
21MP0005365_abnormal_bile_salt2.10290654
22MP0000569_abnormal_digit_pigmentation2.08680725
23MP0004043_abnormal_pH_regulation2.06749222
24MP0010352_gastrointestinal_tract_polyps2.05492204
25MP0005499_abnormal_olfactory_system2.05063055
26MP0005394_taste/olfaction_phenotype2.05063055
27MP0006276_abnormal_autonomic_nervous2.01934908
28MP0003283_abnormal_digestive_organ1.96190341
29MP0005075_abnormal_melanosome_morpholog1.94886039
30MP0002909_abnormal_adrenal_gland1.91300994
31MP0002102_abnormal_ear_morphology1.88668113
32MP0001835_abnormal_antigen_presentation1.87562987
33MP0008875_abnormal_xenobiotic_pharmacok1.87272723
34MP0003300_gastrointestinal_ulcer1.86197400
35MP0003172_abnormal_lysosome_physiology1.86037974
36MP0001529_abnormal_vocalization1.83639445
37MP0004147_increased_porphyrin_level1.78915108
38MP0006292_abnormal_olfactory_placode1.78229243
39MP0005084_abnormal_gallbladder_morpholo1.77286380
40MP0010386_abnormal_urinary_bladder1.77164077
41MP0003705_abnormal_hypodermis_morpholog1.73913256
42MP0009785_altered_susceptibility_to1.73877887
43MP0001984_abnormal_olfaction1.73783767
44MP0005275_abnormal_skin_tensile1.70563044
45MP0002938_white_spotting1.70339226
46MP0002638_abnormal_pupillary_reflex1.69198307
47MP0005671_abnormal_response_to1.67639564
48MP0000778_abnormal_nervous_system1.67296518
49MP0004142_abnormal_muscle_tone1.67252742
50MP0005085_abnormal_gallbladder_physiolo1.66968419
51MP0001542_abnormal_bone_strength1.65627061
52MP0003122_maternal_imprinting1.65392650
53MP0006035_abnormal_mitochondrial_morpho1.64265499
54MP0002272_abnormal_nervous_system1.54675233
55MP0002090_abnormal_vision1.54092693
56MP0003186_abnormal_redox_activity1.53661041
57MP0004134_abnormal_chest_morphology1.49118761
58MP0002295_abnormal_pulmonary_circulatio1.47495144
59MP0002837_dystrophic_cardiac_calcinosis1.46882356
60MP0003252_abnormal_bile_duct1.46405365
61MP0005319_abnormal_enzyme/_coenzyme1.46045349
62MP0009764_decreased_sensitivity_to1.45334482
63MP0005000_abnormal_immune_tolerance1.45043736
64MP0006054_spinal_hemorrhage1.44702981
65MP0008438_abnormal_cutaneous_collagen1.41965192
66MP0000609_abnormal_liver_physiology1.41351870
67MP0001299_abnormal_eye_distance/1.37960623
68MP0005025_abnormal_response_to1.37629366
69MP0004133_heterotaxia1.37553169
70MP0000013_abnormal_adipose_tissue1.36415561
71MP0009780_abnormal_chondrocyte_physiolo1.36051720
72MP0003724_increased_susceptibility_to1.35389643
73MP0009745_abnormal_behavioral_response1.34996318
74MP0010329_abnormal_lipoprotein_level1.33700213
75MP0001440_abnormal_grooming_behavior1.33545940
76MP0001790_abnormal_immune_system1.32367074
77MP0005387_immune_system_phenotype1.32367074
78MP0003787_abnormal_imprinting1.32195265
79MP0005187_abnormal_penis_morphology1.30362505
80MP0004270_analgesia1.26872517
81MP0002557_abnormal_social/conspecific_i1.26534798
82MP0001800_abnormal_humoral_immune1.26496937
83MP0002751_abnormal_autonomic_nervous1.26354110
84MP0002184_abnormal_innervation1.24778315
85MP0002877_abnormal_melanocyte_morpholog1.24080650
86MP0002572_abnormal_emotion/affect_behav1.22816571
87MP0002396_abnormal_hematopoietic_system1.21892432
88MP0005551_abnormal_eye_electrophysiolog1.21605213
89MP0000516_abnormal_urinary_system1.18832800
90MP0005367_renal/urinary_system_phenotyp1.18832800
91MP0002234_abnormal_pharynx_morphology1.18437729
92MP0008789_abnormal_olfactory_epithelium1.16517225
93MP0002064_seizures1.16089136
94MP0000631_abnormal_neuroendocrine_gland1.14991882
95MP0003191_abnormal_cellular_cholesterol1.14253981
96MP0000955_abnormal_spinal_cord1.12349646
97MP0002723_abnormal_immune_serum1.12340316
98MP0008469_abnormal_protein_level1.11929953
99MP0001819_abnormal_immune_cell1.10588838
100MP0010155_abnormal_intestine_physiology1.10348379
101MP0000647_abnormal_sebaceous_gland1.09450999
102MP0002420_abnormal_adaptive_immunity1.09412175
103MP0003763_abnormal_thymus_physiology1.08585336
104MP0003136_yellow_coat_color1.07814883
105MP0003635_abnormal_synaptic_transmissio1.07694353
106MP0002452_abnormal_antigen_presenting1.07634569
107MP0005386_behavior/neurological_phenoty1.07246579
108MP0004924_abnormal_behavior1.07246579
109MP0002653_abnormal_ependyma_morphology1.06578677
110MP0001486_abnormal_startle_reflex1.05488221
111MP0003221_abnormal_cardiomyocyte_apopto1.05305253
112MP0004811_abnormal_neuron_physiology1.04638650
113MP0003950_abnormal_plasma_membrane1.04590015
114MP0001845_abnormal_inflammatory_respons1.04467327
115MP0002735_abnormal_chemical_nociception1.03999332
116MP0001905_abnormal_dopamine_level1.03775766
117MP0005389_reproductive_system_phenotype1.03622558
118MP0002233_abnormal_nose_morphology1.03214120
119MP0005391_vision/eye_phenotype1.03188350
120MP0010234_abnormal_vibrissa_follicle1.03139253
121MP0003755_abnormal_palate_morphology1.03107187
122MP0002127_abnormal_cardiovascular_syste1.02355979
123MP0003195_calcinosis1.02324840
124MP0003448_altered_tumor_morphology1.00648555
125MP0002970_abnormal_white_adipose1.00063879
126MP0002419_abnormal_innate_immunity0.99473394
127MP0000343_altered_response_to0.98852359
128MP0005257_abnormal_intraocular_pressure0.98466628
129MP0002063_abnormal_learning/memory/cond0.98426606
130MP0002067_abnormal_sensory_capabilities0.98399753
131MP0004947_skin_inflammation0.98122751
132MP0005083_abnormal_biliary_tract0.97837397
133MP0010368_abnormal_lymphatic_system0.96193352
134MP0002138_abnormal_hepatobiliary_system0.95384663
135MP0002734_abnormal_mechanical_nocicepti0.94551610
136MP0004782_abnormal_surfactant_physiolog0.93828362
137MP0004885_abnormal_endolymph0.93520422
138MP0002160_abnormal_reproductive_system0.93194764
139MP0009384_cardiac_valve_regurgitation0.93109828
140MP0003121_genomic_imprinting0.92817327
141MP0002078_abnormal_glucose_homeostasis0.92470352
142MP0001764_abnormal_homeostasis0.91788553
143MP0000716_abnormal_immune_system0.91234010
144MP0001919_abnormal_reproductive_system0.90977877
145MP0002882_abnormal_neuron_morphology0.90966751
146MP0009763_increased_sensitivity_to0.90837862
147MP0002822_catalepsy0.90578246
148MP0002405_respiratory_system_inflammati0.90178757
149MP0002398_abnormal_bone_marrow0.90165396
150MP0000685_abnormal_immune_system0.89992404
151MP0001970_abnormal_pain_threshold0.89401543
152MP0009115_abnormal_fat_cell0.89228007
153MP0003633_abnormal_nervous_system0.88944370
154MP0002752_abnormal_somatic_nervous0.88654618
155MP0005423_abnormal_somatic_nervous0.87813360
156MP0000858_altered_metastatic_potential0.86519581
157MP0000689_abnormal_spleen_morphology0.86022844
158MP0005310_abnormal_salivary_gland0.84525715
159MP0005195_abnormal_posterior_eye0.83897104
160MP0005535_abnormal_body_temperature0.83538997
161MP0004859_abnormal_synaptic_plasticity0.83032751
162MP0003868_abnormal_feces_composition0.82845103
163MP0002722_abnormal_immune_system0.82592756
164MP0000427_abnormal_hair_cycle0.82543172
165MP0004484_altered_response_of0.82443197
166MP0001533_abnormal_skeleton_physiology0.82200495
167MP0001666_abnormal_nutrient_absorption0.81741888
168MP0002736_abnormal_nociception_after0.81585078
169MP0001188_hyperpigmentation0.81030605
170MP0002429_abnormal_blood_cell0.80904551
171MP0006036_abnormal_mitochondrial_physio0.80900753
172MP0001853_heart_inflammation0.80434938
173MP0005584_abnormal_enzyme/coenzyme_acti0.79610693
174MP0009250_abnormal_appendicular_skeleto0.79568092
175MP0000598_abnormal_liver_morphology0.79554014
176MP0005266_abnormal_metabolism0.78808823
177MP0002998_abnormal_bone_remodeling0.77614282
178MP0003303_peritoneal_inflammation0.76881152
179MP0003828_pulmonary_edema0.76377055
180MP0003075_altered_response_to0.76255808
181MP0005670_abnormal_white_adipose0.76242404
182MP0004215_abnormal_myocardial_fiber0.75683241
183MP0009643_abnormal_urine_homeostasis0.74989266
184MP0009765_abnormal_xenobiotic_induced0.74635871
185MP0002693_abnormal_pancreas_physiology0.73517353
186MP0001324_abnormal_eye_pigmentation0.73418164
187MP0008775_abnormal_heart_ventricle0.68637925
188MP0005248_abnormal_Harderian_gland0.68393278

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.40069444
2Bilateral microphthalmos (HP:0007633)5.04164313
3Hepatoblastoma (HP:0002884)4.59202211
4Hyperinsulinemic hypoglycemia (HP:0000825)4.31585272
5Medial flaring of the eyebrow (HP:0010747)3.98061669
6Abnormality of the lower motor neuron (HP:0002366)3.71785531
7Gait imbalance (HP:0002141)3.71157099
8Abnormality of the intrinsic pathway (HP:0010989)3.57137979
9True hermaphroditism (HP:0010459)3.50986290
10Congenital primary aphakia (HP:0007707)3.47858509
11Nephrogenic diabetes insipidus (HP:0009806)3.42630391
12Dyschromatopsia (HP:0007641)3.31792797
13Nasal polyposis (HP:0100582)3.30866329
14Multiple enchondromatosis (HP:0005701)3.26442555
15Ragged-red muscle fibers (HP:0003200)3.22562832
16Pancreatic fibrosis (HP:0100732)3.10623078
17Reduced antithrombin III activity (HP:0001976)3.09063339
18Testicular atrophy (HP:0000029)3.04613943
19Metaphyseal dysplasia (HP:0100255)3.02961799
20Abnormality of midbrain morphology (HP:0002418)2.99763829
21Molar tooth sign on MRI (HP:0002419)2.99763829
22Polyphagia (HP:0002591)2.89992838
23Tetraplegia (HP:0002445)2.85506736
24Pancreatic cysts (HP:0001737)2.80156988
25Intestinal atresia (HP:0011100)2.79261124
26Genital tract atresia (HP:0001827)2.79038635
27Abnormality of the nasal mucosa (HP:0000433)2.77457821
28Hyperventilation (HP:0002883)2.77120145
29Cheilitis (HP:0100825)2.69820785
30Upper motor neuron abnormality (HP:0002127)2.67723505
31Acute necrotizing encephalopathy (HP:0006965)2.61371470
32Limb dystonia (HP:0002451)2.61282141
33Vaginal atresia (HP:0000148)2.60113797
34Skin nodule (HP:0200036)2.59777340
35Abnormal cartilage morphology (HP:0002763)2.59089808
36Villous atrophy (HP:0011473)2.56031881
37Abnormality of small intestinal villus morphology (HP:0011472)2.56031881
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.53117297
39Progressive macrocephaly (HP:0004481)2.52457212
40Amyotrophic lateral sclerosis (HP:0007354)2.49939860
41Resting tremor (HP:0002322)2.48274131
42Delayed gross motor development (HP:0002194)2.47922719
43Bifid tongue (HP:0010297)2.46397271
44Thyroid carcinoma (HP:0002890)2.44866488
45Occipital encephalocele (HP:0002085)2.43038362
46Methylmalonic acidemia (HP:0002912)2.41073158
47Hypochromic anemia (HP:0001931)2.38034790
48Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.37817179
49Degeneration of the lateral corticospinal tracts (HP:0002314)2.37705651
50Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37705651
51Horizontal nystagmus (HP:0000666)2.37048496
52Aplasia/Hypoplasia of the fovea (HP:0008060)2.36819258
53Hypoplasia of the fovea (HP:0007750)2.36819258
54Atonic seizures (HP:0010819)2.36383614
55Chronic hepatic failure (HP:0100626)2.31593866
56Hypothermia (HP:0002045)2.31250795
57Hip dysplasia (HP:0001385)2.30530852
58Focal motor seizures (HP:0011153)2.29685889
59Gout (HP:0001997)2.28485984
60Large for gestational age (HP:0001520)2.25792055
61Increased hepatocellular lipid droplets (HP:0006565)2.24761012
62Failure to thrive in infancy (HP:0001531)2.21840536
63Gingivitis (HP:0000230)2.21718389
64Absent speech (HP:0001344)2.21286416
65Mitochondrial inheritance (HP:0001427)2.20189594
66Postaxial hand polydactyly (HP:0001162)2.18659485
67Renal Fanconi syndrome (HP:0001994)2.18450261
68Pancreatic islet-cell hyperplasia (HP:0004510)2.18090539
69Poor coordination (HP:0002370)2.18007341
70Eczematoid dermatitis (HP:0000976)2.17687778
71Narrow forehead (HP:0000341)2.17341068
72Absent frontal sinuses (HP:0002688)2.16837630
73Ketoacidosis (HP:0001993)2.16406109
74Aplasia/hypoplasia of the uterus (HP:0008684)2.15745646
75Short tibia (HP:0005736)2.14475447
76Ependymoma (HP:0002888)2.14202909
77Abnormality of glycolipid metabolism (HP:0010969)2.13792433
78Abnormality of liposaccharide metabolism (HP:0010968)2.13792433
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.13792433
80Limb hypertonia (HP:0002509)2.13542794
81Orchitis (HP:0100796)2.13510313
82Nephronophthisis (HP:0000090)2.12625155
83Medulloblastoma (HP:0002885)2.11892880
84Hand muscle atrophy (HP:0009130)2.11715511
85Abnormal respiratory motile cilium physiology (HP:0012261)2.10820291
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10372883
87Renal cortical cysts (HP:0000803)2.10263510
88Micronodular cirrhosis (HP:0001413)2.09698530
89Combined immunodeficiency (HP:0005387)2.08141987
90Median cleft lip (HP:0000161)2.05431864
91Abnormal ciliary motility (HP:0012262)2.05357889
92Elevated erythrocyte sedimentation rate (HP:0003565)2.05143370
93Abnormality of the corticospinal tract (HP:0002492)2.05071441
94Scotoma (HP:0000575)2.04782646
95Febrile seizures (HP:0002373)2.04496426
96Abnormality of macular pigmentation (HP:0008002)2.02854360
97Decreased testicular size (HP:0008734)2.02030033
98Muscular hypotonia of the trunk (HP:0008936)2.01845897
99Neoplasm of striated muscle (HP:0009728)2.01823530
100Aplasia/Hypoplasia of the tibia (HP:0005772)2.01364951
101Agnosia (HP:0010524)2.01160282
102Aplasia/Hypoplasia of the lens (HP:0008063)2.00634830
103Hepatic necrosis (HP:0002605)2.00086982
104Increased CSF protein (HP:0002922)1.98444574
105Anencephaly (HP:0002323)1.98167451
106Rhabdomyosarcoma (HP:0002859)1.97941975
107Abnormal mitochondria in muscle tissue (HP:0008316)1.97671176
108Rib fusion (HP:0000902)1.97600504
109Neoplasm of the tracheobronchial system (HP:0100552)1.97510477
110Neoplasm of the heart (HP:0100544)1.97126661
111Drooling (HP:0002307)1.97053829
112Increased CSF lactate (HP:0002490)1.96927016
113Abnormality of iron homeostasis (HP:0011031)1.96571645
114Specific learning disability (HP:0001328)1.96509776
115Acute encephalopathy (HP:0006846)1.96397942
116Poor suck (HP:0002033)1.95895651
117Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94625187
118EEG with generalized epileptiform discharges (HP:0011198)1.94207720
119Hypsarrhythmia (HP:0002521)1.93515687
120Epileptiform EEG discharges (HP:0011182)1.92465802
121Agitation (HP:0000713)1.91675127
122Postaxial foot polydactyly (HP:0001830)1.91549397
123Broad foot (HP:0001769)1.89711243
124Recurrent gram-negative bacterial infections (HP:0005420)1.89604554
125Spastic tetraparesis (HP:0001285)1.89464333
126Increased IgM level (HP:0003496)1.89105149
127Abnormality of the fovea (HP:0000493)1.88991772
128Intestinal fistula (HP:0100819)1.88792853
129Nephroblastoma (Wilms tumor) (HP:0002667)1.87610093
130Abnormality of the labia minora (HP:0012880)1.86226534
131Hypoglycemic seizures (HP:0002173)1.84609618
132Myositis (HP:0100614)1.84486363
133Disproportionate short-trunk short stature (HP:0003521)1.83818155
134Increased serum ferritin (HP:0003281)1.83435542
135Malnutrition (HP:0004395)1.83296524
136Rhinitis (HP:0012384)1.82663860
137Lipid accumulation in hepatocytes (HP:0006561)1.82328123
138Central scotoma (HP:0000603)1.82093410
139Abnormality of renal resorption (HP:0011038)1.82090383
140Short foot (HP:0001773)1.81855180
141Chest pain (HP:0100749)1.81777429
142Abnormality of the common coagulation pathway (HP:0010990)1.81565540
143Focal seizures (HP:0007359)1.80795469
144Dialeptic seizures (HP:0011146)1.80767188
145Thyroiditis (HP:0100646)1.79323756
146Gingival bleeding (HP:0000225)1.79250869
147Status epilepticus (HP:0002133)1.78823994
148Recurrent viral infections (HP:0004429)1.78706613
149Generalized hypotonia (HP:0001290)1.77389144
150Aplasia/Hypoplasia of the macula (HP:0008059)1.77372304
151Abnormality of transition element cation homeostasis (HP:0011030)1.77358550
152Hypoglycemic coma (HP:0001325)1.77098489
153T lymphocytopenia (HP:0005403)1.76413752
154Action tremor (HP:0002345)1.75360554
155Atrophy/Degeneration involving motor neurons (HP:0007373)1.75345197
156Hypoplastic left heart (HP:0004383)1.75329201
157Tubulointerstitial nephritis (HP:0001970)1.74950792
158Periodontitis (HP:0000704)1.74919919
159Abnormality of the renal medulla (HP:0100957)1.74786619
160Mutism (HP:0002300)1.73422990
161Abnormal respiratory epithelium morphology (HP:0012253)1.73370524
162Abnormal respiratory motile cilium morphology (HP:0005938)1.73370524
163Rimmed vacuoles (HP:0003805)1.71933698
164Generalized myoclonic seizures (HP:0002123)1.71819546
1653-Methylglutaconic aciduria (HP:0003535)1.71646132
166Male pseudohermaphroditism (HP:0000037)1.71437003
167Excessive salivation (HP:0003781)1.71417286
168Joint hemorrhage (HP:0005261)1.71209478
169Patchy hypopigmentation of hair (HP:0011365)1.70778524
170Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70686655
171Follicular hyperkeratosis (HP:0007502)1.70657841
172Reticulocytosis (HP:0001923)1.70367005
173Absence seizures (HP:0002121)1.70158845
174Recurrent abscess formation (HP:0002722)1.69160903
175Premature loss of primary teeth (HP:0006323)1.68930952
176Tapered finger (HP:0001182)1.66914558
177Rectal fistula (HP:0100590)1.66872498
178Rectovaginal fistula (HP:0000143)1.66872498
179Embryonal renal neoplasm (HP:0011794)1.65095765
180Impaired proprioception (HP:0010831)1.64878675
181Broad palm (HP:0001169)1.64516141
182Mildly elevated creatine phosphokinase (HP:0008180)1.63112806
183Macroorchidism (HP:0000053)1.61858795
184Hypercholesterolemia (HP:0003124)1.61808598
185Abnormality of purine metabolism (HP:0004352)1.61672716
186Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60132598
187Papillary thyroid carcinoma (HP:0002895)1.59853412
188Curly hair (HP:0002212)1.59314815
189Abnormality of T cell number (HP:0011839)1.58828918
190Vaginal fistula (HP:0004320)1.58047862
191Aplastic anemia (HP:0001915)1.56221205
192Autoimmune thrombocytopenia (HP:0001973)1.55001733
193Increased connective tissue (HP:0009025)1.54228432
194Aplasia/Hypoplasia affecting the retina (HP:0008061)1.53493293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.10015276
2ERN15.26678683
3GRK63.73755723
4GRK53.67689582
5ERBB33.16246109
6TRIM282.84601882
7MAP3K42.83396580
8CDK192.80935426
9TGFBR22.70528861
10MAP3K102.69787067
11WNK32.64906994
12ADRBK22.64807462
13BCR2.63204452
14MARK12.63061899
15CASK2.58681137
16TNIK2.56575124
17FGFR32.51490308
18MAP2K72.48708530
19EIF2AK32.32511685
20GRK12.18868233
21CSF1R2.11150785
22MAP4K22.03038140
23GRK72.00581742
24STK101.98501984
25PLK21.89903095
26PINK11.86633232
27DYRK31.83705272
28MAPK71.80265235
29MAP2K41.74889366
30MATK1.63503559
31MAPK131.62240050
32PRKG21.56688749
33HIPK21.53413280
34TYK21.48424803
35SRPK11.48269713
36ITK1.45368777
37WNK11.43499185
38PAK31.41180835
39AKT31.40997389
40RIPK41.36509759
41MST41.36238178
42JAK31.35249899
43TAOK31.32982255
44PNCK1.30541016
45TXK1.29700142
46JAK11.29396018
47ACVR1B1.28855445
48BMPR21.27521425
49FGFR41.26120159
50STK38L1.24719416
51TYRO31.22261885
52CSK1.21303405
53FRK1.16371719
54MINK11.16284804
55STK391.15025589
56MAP3K141.14344211
57CAMK41.13278063
58PRKCE1.11229301
59RIPK11.10541215
60DYRK21.08039957
61NTRK11.05148142
62MOS1.03951274
63BMPR1B0.98144337
64IRAK10.97420747
65FLT30.96966550
66IKBKE0.94918351
67PLK30.94611481
68INSRR0.92683909
69TSSK60.91785714
70MAP3K60.91656508
71KIT0.90990502
72CSNK1G20.89239756
73MKNK20.89194459
74MAP3K130.89125268
75NUAK10.85984361
76PRKCG0.84952406
77CSNK1G10.84131974
78NLK0.83924896
79MYLK0.82179787
80JAK20.81415937
81IRAK40.81356252
82FER0.81180376
83MAPK120.80960599
84LIMK10.80529123
85STK30.80032134
86ADRBK10.77471470
87MAP3K70.77376283
88MAP4K10.76963842
89ZAP700.74632735
90DYRK1A0.73289071
91CAMK2A0.73266854
92PKN10.72539288
93EPHA30.71415301
94TAF10.70045878
95DDR20.69341761
96MKNK10.68789549
97MAP2K60.67435946
98KSR10.64847341
99IKBKB0.64761062
100TBK10.64165444
101PASK0.63865440
102EPHB20.63587413
103CSNK1G30.62925186
104TRIB30.61790312
105MAP2K30.61505039
106EIF2AK10.60325517
107SGK30.59650068
108EPHB10.57901396
109IGF1R0.57312012
110STK240.56592933
111SIK10.56559436
112STK160.56479002
113DAPK20.56150726
114CSNK1A1L0.55997216
115CHUK0.55760473
116NTRK20.55546110
117OXSR10.55150614
118ERBB40.54948460
119TGFBR10.54538568
120PDK10.54522020
121FGFR20.54121929
122SCYL20.54092312
123YES10.54070368
124EPHA40.53997293
125PDK30.53796940
126PDK40.53796940
127GSK3A0.53665411
128WEE10.53659538
129PDGFRA0.51707322
130CLK10.51398945
131PAK40.50344109
132BRSK20.50032861
133PRKCH0.49934359
134SGK20.49487304
135NTRK30.48692671
136LCK0.48519014
137IRAK30.48157284
138MAPKAPK30.47665318
139MUSK0.47405536
140MARK20.46396216
141PRPF4B0.44192175
142PRKCD0.43986649
143MAP3K120.43116812
144UHMK10.42982437
145SYK0.42076616
146PRKCQ0.42069666
147WNK40.41930349
148RPS6KA40.41536061
149LATS10.40578746
150TEC0.40144227
151PRKACG0.39903453
152BRSK10.39597680
153CDK30.39242524
154MARK30.39055970
155PRKG10.37709379
156CAMKK20.37120416
157SIK30.37078937
158PRKACA0.36784008
159CDK50.36715349
160STK40.36041325
161CAMK2D0.35368770
162ROCK20.32775463
163IRAK20.32387303
164HCK0.31044757
165MAP3K20.30703777
166PRKAA10.30509472
167MAPK110.30343369
168MAP3K50.29085049
169PTK20.28677442
170TAOK20.27953214
171INSR0.26498296
172TTK0.25310542
173TTN0.23475579
174EGFR0.23440902
175MAP3K10.23399971
176SIK20.23026965
177PTK60.22502478
178MAPK100.22338534
179PDK20.22328582

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.17899261
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.67438974
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64072322
4Oxidative phosphorylation_Homo sapiens_hsa001902.85894815
5Propanoate metabolism_Homo sapiens_hsa006402.37081645
6Parkinsons disease_Homo sapiens_hsa050122.34937359
7Caffeine metabolism_Homo sapiens_hsa002322.32459483
8Fructose and mannose metabolism_Homo sapiens_hsa000512.29494393
9Fatty acid elongation_Homo sapiens_hsa000622.24429076
10Collecting duct acid secretion_Homo sapiens_hsa049662.16659308
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10181981
12Butanoate metabolism_Homo sapiens_hsa006502.06200215
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99705800
14Basal transcription factors_Homo sapiens_hsa030221.87801580
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82641366
16Nicotine addiction_Homo sapiens_hsa050331.80937237
17Leishmaniasis_Homo sapiens_hsa051401.76977198
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76284302
19Steroid biosynthesis_Homo sapiens_hsa001001.71854111
20Folate biosynthesis_Homo sapiens_hsa007901.67317404
21Galactose metabolism_Homo sapiens_hsa000521.64670055
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.63061266
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58529502
24African trypanosomiasis_Homo sapiens_hsa051431.57849814
25* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57244485
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.55634896
27Phototransduction_Homo sapiens_hsa047441.52038963
28Alzheimers disease_Homo sapiens_hsa050101.48473088
29Huntingtons disease_Homo sapiens_hsa050161.47867157
30Circadian rhythm_Homo sapiens_hsa047101.47341548
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46648251
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46429734
33Staphylococcus aureus infection_Homo sapiens_hsa051501.40378488
34Proteasome_Homo sapiens_hsa030501.39932281
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38185426
36Synaptic vesicle cycle_Homo sapiens_hsa047211.37565557
37Peroxisome_Homo sapiens_hsa041461.37085331
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35459720
39Sulfur metabolism_Homo sapiens_hsa009201.34582674
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.34256554
41Renin-angiotensin system_Homo sapiens_hsa046141.32485891
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.29801338
43Complement and coagulation cascades_Homo sapiens_hsa046101.25912338
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22489997
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21794901
46ABC transporters_Homo sapiens_hsa020101.21721256
47mTOR signaling pathway_Homo sapiens_hsa041501.21338808
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21150331
49T cell receptor signaling pathway_Homo sapiens_hsa046601.21023834
50Tryptophan metabolism_Homo sapiens_hsa003801.20684356
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20339160
52Vitamin B6 metabolism_Homo sapiens_hsa007501.18008506
53Legionellosis_Homo sapiens_hsa051341.15805318
54Dopaminergic synapse_Homo sapiens_hsa047281.15554756
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12546592
56Insulin resistance_Homo sapiens_hsa049311.11903119
57Cocaine addiction_Homo sapiens_hsa050301.11771210
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09142050
59Influenza A_Homo sapiens_hsa051641.07524796
60Thyroid cancer_Homo sapiens_hsa052161.07084989
61Measles_Homo sapiens_hsa051621.06525086
62Osteoclast differentiation_Homo sapiens_hsa043801.03698089
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02363591
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01184932
65Acute myeloid leukemia_Homo sapiens_hsa052211.01147451
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00832598
67Morphine addiction_Homo sapiens_hsa050321.00828453
68Type I diabetes mellitus_Homo sapiens_hsa049401.00731471
69Bile secretion_Homo sapiens_hsa049760.99139080
70Circadian entrainment_Homo sapiens_hsa047130.99130710
71Arginine biosynthesis_Homo sapiens_hsa002200.98778178
72Insulin secretion_Homo sapiens_hsa049110.98112972
73Glutamatergic synapse_Homo sapiens_hsa047240.95659732
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.95649224
75Toxoplasmosis_Homo sapiens_hsa051450.95159806
76Pyruvate metabolism_Homo sapiens_hsa006200.95089479
77B cell receptor signaling pathway_Homo sapiens_hsa046620.94951882
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94523298
79Cardiac muscle contraction_Homo sapiens_hsa042600.93660277
80Graft-versus-host disease_Homo sapiens_hsa053320.93325672
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93325513
82Primary immunodeficiency_Homo sapiens_hsa053400.91186240
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.90337371
84Other glycan degradation_Homo sapiens_hsa005110.89921427
85Fatty acid degradation_Homo sapiens_hsa000710.89185249
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88546484
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88287644
88Hematopoietic cell lineage_Homo sapiens_hsa046400.88110012
89PPAR signaling pathway_Homo sapiens_hsa033200.87219062
90Vibrio cholerae infection_Homo sapiens_hsa051100.86591818
91Tuberculosis_Homo sapiens_hsa051520.85546439
92Prolactin signaling pathway_Homo sapiens_hsa049170.82771293
93Glutathione metabolism_Homo sapiens_hsa004800.81747100
94Inositol phosphate metabolism_Homo sapiens_hsa005620.81631592
95Hedgehog signaling pathway_Homo sapiens_hsa043400.81503020
96Starch and sucrose metabolism_Homo sapiens_hsa005000.80899492
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80135228
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80099290
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79649551
100Type II diabetes mellitus_Homo sapiens_hsa049300.79338372
101Amphetamine addiction_Homo sapiens_hsa050310.77888790
102Long-term potentiation_Homo sapiens_hsa047200.76245338
103Hepatitis C_Homo sapiens_hsa051600.75772711
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75702282
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74636582
106RNA degradation_Homo sapiens_hsa030180.73772234
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73686156
108Pertussis_Homo sapiens_hsa051330.73620378
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73445106
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72223059
111Herpes simplex infection_Homo sapiens_hsa051680.71711636
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71263857
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.70678296
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69969482
115Axon guidance_Homo sapiens_hsa043600.68475093
116Fatty acid metabolism_Homo sapiens_hsa012120.68054499
117Intestinal immune network for IgA production_Homo sapiens_hsa046720.68001003
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66575323
119TNF signaling pathway_Homo sapiens_hsa046680.65423536
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63342248
121Chemokine signaling pathway_Homo sapiens_hsa040620.63294475
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62999503
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62227473
124Lysine degradation_Homo sapiens_hsa003100.62172329
125Non-small cell lung cancer_Homo sapiens_hsa052230.61984679
126Taste transduction_Homo sapiens_hsa047420.61624450
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61142742
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60981481
129Pancreatic cancer_Homo sapiens_hsa052120.60761286
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.59876699
131Serotonergic synapse_Homo sapiens_hsa047260.59741823
132Metabolic pathways_Homo sapiens_hsa011000.59205384
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58033290
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.57752531
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57548220
136VEGF signaling pathway_Homo sapiens_hsa043700.57044598
137Oocyte meiosis_Homo sapiens_hsa041140.56989238
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56801832
139Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55016419
140Glycerolipid metabolism_Homo sapiens_hsa005610.54152955
141Antigen processing and presentation_Homo sapiens_hsa046120.52407795
142beta-Alanine metabolism_Homo sapiens_hsa004100.51864623
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.51503720
144TGF-beta signaling pathway_Homo sapiens_hsa043500.51442957
145Dorso-ventral axis formation_Homo sapiens_hsa043200.51406156
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51227210
147Ovarian steroidogenesis_Homo sapiens_hsa049130.50708070
148GABAergic synapse_Homo sapiens_hsa047270.49357152
149Phagosome_Homo sapiens_hsa041450.48646643
150Mineral absorption_Homo sapiens_hsa049780.48419498
151Regulation of autophagy_Homo sapiens_hsa041400.47565060
152Olfactory transduction_Homo sapiens_hsa047400.46493403
153Fat digestion and absorption_Homo sapiens_hsa049750.46129174
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.45604891
155Apoptosis_Homo sapiens_hsa042100.44891276
156Arachidonic acid metabolism_Homo sapiens_hsa005900.43874524
157Nitrogen metabolism_Homo sapiens_hsa009100.43050928
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42972676
159Gap junction_Homo sapiens_hsa045400.42180800
160Chemical carcinogenesis_Homo sapiens_hsa052040.42049223
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41827683
162Central carbon metabolism in cancer_Homo sapiens_hsa052300.41816851
163Platelet activation_Homo sapiens_hsa046110.41653101
1642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41638151
165Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41571894
166Glucagon signaling pathway_Homo sapiens_hsa049220.41407238
167Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40847587
168RNA polymerase_Homo sapiens_hsa030200.40475892
169Retinol metabolism_Homo sapiens_hsa008300.39540121
170Long-term depression_Homo sapiens_hsa047300.38982520
171Non-homologous end-joining_Homo sapiens_hsa034500.38380671
172Sphingolipid metabolism_Homo sapiens_hsa006000.38211845
173N-Glycan biosynthesis_Homo sapiens_hsa005100.36361012
174Cholinergic synapse_Homo sapiens_hsa047250.31033771
175Salmonella infection_Homo sapiens_hsa051320.30078408
176Basal cell carcinoma_Homo sapiens_hsa052170.29841771
177Rheumatoid arthritis_Homo sapiens_hsa053230.28268686
178Fanconi anemia pathway_Homo sapiens_hsa034600.27620581
179Hippo signaling pathway_Homo sapiens_hsa043900.27541332
180Ether lipid metabolism_Homo sapiens_hsa005650.26191618

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