AZIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)5.18375464
2Golgi transport vesicle coating (GO:0048200)4.91665349
3COPI coating of Golgi vesicle (GO:0048205)4.91665349
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.31166190
5protein complex localization (GO:0031503)4.14899929
6pyrimidine nucleobase catabolic process (GO:0006208)4.11162696
7nucleobase catabolic process (GO:0046113)4.09000940
8establishment of viral latency (GO:0019043)4.06273665
9purine nucleobase biosynthetic process (GO:0009113)4.01022846
10ribosome assembly (GO:0042255)3.97643995
11mitotic sister chromatid cohesion (GO:0007064)3.95639116
12pre-miRNA processing (GO:0031054)3.80260966
13vesicle coating (GO:0006901)3.75089960
14monoubiquitinated protein deubiquitination (GO:0035520)3.72618376
15UDP-N-acetylglucosamine metabolic process (GO:0006047)3.70363640
16histone-serine phosphorylation (GO:0035404)3.63228775
17maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62203792
18vitamin transmembrane transport (GO:0035461)3.61837592
19clathrin coat assembly (GO:0048268)3.59065835
20nuclear pore complex assembly (GO:0051292)3.58384618
21double-strand break repair via nonhomologous end joining (GO:0006303)3.57367805
22non-recombinational repair (GO:0000726)3.57367805
23regulation of centriole replication (GO:0046599)3.51137421
24nuclear pore organization (GO:0006999)3.49208094
25layer formation in cerebral cortex (GO:0021819)3.46578792
26cellular protein complex localization (GO:0034629)3.45000638
27regulation of helicase activity (GO:0051095)3.44971383
28L-serine metabolic process (GO:0006563)3.34532054
29mitotic spindle checkpoint (GO:0071174)3.33684578
30nucleobase biosynthetic process (GO:0046112)3.32735072
31protein localization to kinetochore (GO:0034501)3.32714346
32IMP metabolic process (GO:0046040)3.32325519
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32152893
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32152893
35positive regulation of mitotic sister chromatid separation (GO:1901970)3.32152893
36negative regulation of sister chromatid segregation (GO:0033046)3.32012377
37negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.32012377
38negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.32012377
39negative regulation of mitotic sister chromatid segregation (GO:0033048)3.32012377
40negative regulation of mitotic sister chromatid separation (GO:2000816)3.32012377
41negative regulation of DNA recombination (GO:0045910)3.31696865
42IMP biosynthetic process (GO:0006188)3.30341238
43iron ion import (GO:0097286)3.29014786
44DNA unwinding involved in DNA replication (GO:0006268)3.28076109
45negative regulation of chromosome segregation (GO:0051985)3.26270310
46DNA double-strand break processing (GO:0000729)3.22548411
47negative regulation of sodium ion transport (GO:0010766)3.22246541
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22087997
49paraxial mesoderm development (GO:0048339)3.21682987
50intestinal absorption (GO:0050892)3.21520394
51DNA ligation (GO:0006266)3.18540928
52mitotic chromosome condensation (GO:0007076)3.18012239
53regulation of RNA export from nucleus (GO:0046831)3.17756311
54sister chromatid segregation (GO:0000819)3.16910817
55regulation of spindle organization (GO:0090224)3.15536357
56regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.10270881
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.10270881
58folic acid transport (GO:0015884)3.10195646
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.07721872
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.07721872
61protein retention in ER lumen (GO:0006621)3.05370801
62chromatin remodeling at centromere (GO:0031055)3.04876442
63CENP-A containing nucleosome assembly (GO:0034080)3.04525362
64axonemal dynein complex assembly (GO:0070286)3.04270141
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03433780
66regulation of mitotic sister chromatid separation (GO:0010965)3.03044387
67regulation of mitotic sister chromatid segregation (GO:0033047)3.03044387
68regulation of sister chromatid segregation (GO:0033045)3.03044387
69mitotic spindle assembly checkpoint (GO:0007094)3.02659310
70intestinal cholesterol absorption (GO:0030299)3.01342751
71positive regulation of chromosome segregation (GO:0051984)2.99816235
72regulation of nucleobase-containing compound transport (GO:0032239)2.98853748
73spindle assembly checkpoint (GO:0071173)2.97058699
74COPII vesicle coating (GO:0048208)2.92095709
75DNA damage response, detection of DNA damage (GO:0042769)2.90219362
76DNA replication-independent nucleosome organization (GO:0034724)2.88180645
77DNA replication-independent nucleosome assembly (GO:0006336)2.88180645
78RNA-dependent DNA replication (GO:0006278)2.84714777
79mitotic metaphase plate congression (GO:0007080)2.82099821
80positive regulation of muscle hypertrophy (GO:0014742)2.81073817
81positive regulation of cardiac muscle hypertrophy (GO:0010613)2.81073817
82pore complex assembly (GO:0046931)2.81031775
83ATP-dependent chromatin remodeling (GO:0043044)2.80606697
84regulation of germinal center formation (GO:0002634)2.79726789
85DNA replication-dependent nucleosome assembly (GO:0006335)2.74880444
86DNA replication-dependent nucleosome organization (GO:0034723)2.74880444
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.74547086
88regulation of mitotic spindle checkpoint (GO:1903504)2.74547086
89DNA topological change (GO:0006265)2.74503090
90protoporphyrinogen IX metabolic process (GO:0046501)2.72799043
91DNA strand elongation involved in DNA replication (GO:0006271)2.72055476
92negative regulation of fibroblast apoptotic process (GO:2000270)2.71691931
93microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.71482595
94regulation of sister chromatid cohesion (GO:0007063)2.71202448
95tRNA aminoacylation for protein translation (GO:0006418)2.70842886
96hormone catabolic process (GO:0042447)2.70235350
97membrane disassembly (GO:0030397)2.69285498
98nuclear envelope disassembly (GO:0051081)2.69285498
99histone exchange (GO:0043486)2.68019622
100DNA duplex unwinding (GO:0032508)2.67246050
101cytoplasmic mRNA processing body assembly (GO:0033962)2.66713535
102mitochondrial genome maintenance (GO:0000002)2.66265118
103proline transport (GO:0015824)2.64763352
104formation of translation preinitiation complex (GO:0001731)2.63368805
105DNA strand elongation (GO:0022616)2.63293581
106de novo protein folding (GO:0006458)2.63060741
107amino acid activation (GO:0043038)2.61812932
108tRNA aminoacylation (GO:0043039)2.61812932
109histone arginine methylation (GO:0034969)2.61040507
110cell adhesion mediated by integrin (GO:0033627)2.60839661
111DNA geometric change (GO:0032392)2.60783417
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.60164734
113regulation of DNA endoreduplication (GO:0032875)2.59936156
114spindle assembly involved in mitosis (GO:0090307)2.59288959
115regulation of gene silencing by RNA (GO:0060966)2.58809158
116regulation of posttranscriptional gene silencing (GO:0060147)2.58809158
117regulation of gene silencing by miRNA (GO:0060964)2.58809158
118membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.58424859
119positive regulation of nuclease activity (GO:0032075)2.57814823
120vesicle transport along microtubule (GO:0047496)2.56807887
121attachment of spindle microtubules to kinetochore (GO:0008608)2.56794280
122negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.56508368
123neuron projection extension (GO:1990138)2.55320674
124regulation of synaptic vesicle exocytosis (GO:2000300)2.54990826
125synaptic vesicle maturation (GO:0016188)2.54948400
126hyperosmotic salinity response (GO:0042538)2.53776836
127activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53572829
128cell fate commitment involved in formation of primary germ layer (GO:0060795)2.52455565
129negative regulation of mRNA metabolic process (GO:1903312)2.52367955
130negative regulation of mitosis (GO:0045839)2.52295733
131regulation of mitotic spindle organization (GO:0060236)2.52061154
132microtubule depolymerization (GO:0007019)2.51204995
133positive regulation of cell cycle checkpoint (GO:1901978)2.51143888
134positive regulation of nitric-oxide synthase activity (GO:0051000)2.50136844
135glutamine metabolic process (GO:0006541)2.49235915
136telomere maintenance via telomerase (GO:0007004)2.48867799
137regulation of cofactor metabolic process (GO:0051193)2.48067967
138regulation of coenzyme metabolic process (GO:0051196)2.48067967
139de novo posttranslational protein folding (GO:0051084)2.48027369
140cytoskeleton-dependent cytokinesis (GO:0061640)2.48027287
141NLS-bearing protein import into nucleus (GO:0006607)2.46958168
142modified amino acid transport (GO:0072337)2.46375135
143mitotic sister chromatid segregation (GO:0000070)2.45897056
144protoporphyrinogen IX biosynthetic process (GO:0006782)2.44498203
145protein localization to chromosome, centromeric region (GO:0071459)2.44338351
146mitotic nuclear envelope disassembly (GO:0007077)2.43969096
147regulation of nuclease activity (GO:0032069)2.42393918
148positive regulation of synapse maturation (GO:0090129)2.41180261
149dendrite morphogenesis (GO:0048813)2.40670456
150regulation of translational termination (GO:0006449)2.39099026
151axon extension (GO:0048675)2.38929328
152cellular glucuronidation (GO:0052695)2.38544770
153response to arsenic-containing substance (GO:0046685)2.38500654
154membrane repolarization during action potential (GO:0086011)2.36842279
155ER overload response (GO:0006983)2.33613042
156histone phosphorylation (GO:0016572)2.33018775
157endoplasmic reticulum unfolded protein response (GO:0030968)2.32720675
158regulation of short-term neuronal synaptic plasticity (GO:0048172)2.32406122
159metaphase plate congression (GO:0051310)2.31867642
160organelle transport along microtubule (GO:0072384)2.31695392
161regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30732981
162sodium ion export (GO:0071436)2.29444474
163regulation of chromosome segregation (GO:0051983)2.28742803
164positive regulation of axon extension (GO:0045773)2.28224477
165ER-nucleus signaling pathway (GO:0006984)2.27074853
166glutamate secretion (GO:0014047)2.26740284
167cell migration in hindbrain (GO:0021535)2.26690661
168spindle checkpoint (GO:0031577)2.26081257
169cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.25653708
170cell communication by electrical coupling (GO:0010644)2.25432255
171establishment of chromosome localization (GO:0051303)2.24315178
172cellular response to unfolded protein (GO:0034620)2.24093766
173antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)2.23950950
174endoplasmic reticulum organization (GO:0007029)2.23950100
175folic acid metabolic process (GO:0046655)2.23302155
176glial cell proliferation (GO:0014009)2.22745438
177cellular response to arsenic-containing substance (GO:0071243)2.22323964
178nuclear envelope organization (GO:0006998)2.21903548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81466292
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66056047
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.52553234
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.18325690
5GATA1_22025678_ChIP-Seq_K562_Human4.02497474
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.90913735
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78215890
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.75668850
9CLOCK_20551151_ChIP-Seq_293T_Human3.22032936
10AR_21909140_ChIP-Seq_LNCAP_Human3.16314527
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.91854207
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.87707415
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87187125
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.42476304
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.38885732
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31897790
17ELK1_19687146_ChIP-ChIP_HELA_Human2.13984695
18* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.08303223
19ZNF263_19887448_ChIP-Seq_K562_Human2.05560266
20* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.04593743
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.00157971
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96632787
23MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89098495
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88312273
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87992615
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85954977
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83850908
28SALL4_18804426_ChIP-ChIP_XEN_Mouse1.74872676
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73686295
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71797893
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70045348
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69166582
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.68773901
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.68737069
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.67277545
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.66194658
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.64604478
38NANOG_16153702_ChIP-ChIP_HESCs_Human1.62779595
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62633155
40DCP1A_22483619_ChIP-Seq_HELA_Human1.61687083
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60617914
42SOX2_16153702_ChIP-ChIP_HESCs_Human1.58289042
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58013625
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56314562
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56314562
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56314562
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53435250
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.53236704
49AR_21572438_ChIP-Seq_LNCaP_Human1.52632705
50TAF15_26573619_Chip-Seq_HEK293_Human1.52039474
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51329967
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48778772
53* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43615003
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42847081
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42115664
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.38763538
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37855454
58BRD4_25478319_ChIP-Seq_HGPS_Human1.37265991
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34238326
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33946661
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33317027
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32582843
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32241604
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29019538
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28742156
66* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27817240
67* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27817240
68SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27814805
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27785319
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27069966
71* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26984154
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26318240
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25894245
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.24427296
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.24256007
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23939538
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.23074773
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21815386
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.21318028
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19340102
81ZNF274_21170338_ChIP-Seq_K562_Hela1.18904566
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18676366
83CHD1_26751641_Chip-Seq_LNCaP_Human1.17907351
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17727584
85GATA1_26923725_Chip-Seq_HPCs_Mouse1.17039400
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.16443234
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.15418645
88TP53_16413492_ChIP-PET_HCT116_Human1.15355337
89IGF1R_20145208_ChIP-Seq_DFB_Human1.13653864
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.12823807
91* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12103803
92SOX2_20726797_ChIP-Seq_SW620_Human1.11090832
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10761335
94CJUN_26792858_Chip-Seq_BT549_Human1.10126373
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.09853320
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09621285
97SOX17_20123909_ChIP-Seq_XEN_Mouse1.09298887
98EWS_26573619_Chip-Seq_HEK293_Human1.09254933
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08737220
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07954438
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07927908
102* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07476601
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07300568
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06946056
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06781290
106MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06178394
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05286777
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05261716
109* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05110630
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03167407
111P300_19829295_ChIP-Seq_ESCs_Human1.01768668
112GATA4_25053715_ChIP-Seq_YYC3_Human1.01553137
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.01382871
114HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01290607
115* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00666727
116NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99487321
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99023289
118TTF2_22483619_ChIP-Seq_HELA_Human0.98793250
119TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98500640
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.98356261
121GATA2_19941826_ChIP-Seq_K562_Human0.98053367
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97920210
123FUS_26573619_Chip-Seq_HEK293_Human0.97842325
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97191400
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97156848
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97127337
127FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96801244
128TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96644272
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96504370
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96089254
131ATF3_27146783_Chip-Seq_COLON_Human0.95654167
132GABP_19822575_ChIP-Seq_HepG2_Human0.95364858
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94450549
134XRN2_22483619_ChIP-Seq_HELA_Human0.93856756
135VDR_23849224_ChIP-Seq_CD4+_Human0.93224704
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93035611
137* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92808118
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91244733
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90934986
140RXR_22108803_ChIP-Seq_LS180_Human0.90864527
141* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90664679
142HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90290008
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.89865606
144HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.89191988
145GATA1_19941826_ChIP-Seq_K562_Human0.88578730
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87537425
147NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87515372
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87438172
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.86185125
150ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85392672
151GATA6_25053715_ChIP-Seq_YYC3_Human0.85076147
152CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84119187
153* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83250474
154* LXR_22158963_ChIP-Seq_LIVER_Mouse0.83247060
155STAT3_23295773_ChIP-Seq_U87_Human0.83147489
156* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82994554
157* SMAD4_21799915_ChIP-Seq_A2780_Human0.82418378
158* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82132388
159* CDX2_22108803_ChIP-Seq_LS180_Human0.82065672
160EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81641538
161* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.79036218
162AR_25329375_ChIP-Seq_VCAP_Human0.78305998
163JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77947274
164RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77827324
165NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77194826
166NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77194826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.45278192
2MP0003941_abnormal_skin_development3.90441395
3MP0008057_abnormal_DNA_replication3.30406777
4MP0009780_abnormal_chondrocyte_physiolo3.27343102
5MP0010352_gastrointestinal_tract_polyps3.14102312
6MP0005360_urolithiasis3.00186172
7MP0002877_abnormal_melanocyte_morpholog2.97426749
8MP0003656_abnormal_erythrocyte_physiolo2.80028950
9MP0003705_abnormal_hypodermis_morpholog2.70072836
10MP0003303_peritoneal_inflammation2.65554134
11MP0005076_abnormal_cell_differentiation2.62963532
12MP0000569_abnormal_digit_pigmentation2.62535546
13MP0010307_abnormal_tumor_latency2.54534636
14MP0003300_gastrointestinal_ulcer2.51048128
15MP0008932_abnormal_embryonic_tissue2.42027885
16MP0008058_abnormal_DNA_repair2.40930425
17MP0004782_abnormal_surfactant_physiolog2.34762488
18MP0003693_abnormal_embryo_hatching2.30595675
19MP0003183_abnormal_peptide_metabolism2.29768658
20MP0003111_abnormal_nucleus_morphology2.22266471
21MP0001188_hyperpigmentation2.08846826
22MP0002139_abnormal_hepatobiliary_system2.00797983
23MP0004147_increased_porphyrin_level2.00322743
24MP0003221_abnormal_cardiomyocyte_apopto1.89884769
25MP0001666_abnormal_nutrient_absorption1.86385881
26MP0000537_abnormal_urethra_morphology1.86082409
27MP0001529_abnormal_vocalization1.84703405
28MP0005187_abnormal_penis_morphology1.84519516
29MP0008877_abnormal_DNA_methylation1.82667614
30* MP0009672_abnormal_birth_weight1.80673713
31MP0001293_anophthalmia1.78585186
32MP0002822_catalepsy1.73061909
33MP0002084_abnormal_developmental_patter1.70493860
34MP0003123_paternal_imprinting1.68223113
35MP0005623_abnormal_meninges_morphology1.63194674
36MP0001177_atelectasis1.62874102
37MP0010094_abnormal_chromosome_stability1.59354385
38MP0005085_abnormal_gallbladder_physiolo1.57142124
39MP0002909_abnormal_adrenal_gland1.54215417
40MP0002085_abnormal_embryonic_tissue1.54143321
41* MP0009703_decreased_birth_body1.50144074
42MP0002697_abnormal_eye_size1.49752246
43MP0004859_abnormal_synaptic_plasticity1.49499746
44MP0009697_abnormal_copulation1.46454019
45MP0004264_abnormal_extraembryonic_tissu1.44413290
46MP0002254_reproductive_system_inflammat1.44290436
47MP0003937_abnormal_limbs/digits/tail_de1.44192189
48MP0000516_abnormal_urinary_system1.43872580
49MP0005367_renal/urinary_system_phenotyp1.43872580
50MP0001730_embryonic_growth_arrest1.40325298
51MP0009053_abnormal_anal_canal1.37938113
52MP0005365_abnormal_bile_salt1.37511149
53MP0000350_abnormal_cell_proliferation1.36759743
54MP0006054_spinal_hemorrhage1.36132273
55MP0001984_abnormal_olfaction1.34547869
56MP0004270_analgesia1.33698100
57MP0003868_abnormal_feces_composition1.32155622
58MP0010329_abnormal_lipoprotein_level1.31642605
59MP0002896_abnormal_bone_mineralization1.28332368
60MP0003077_abnormal_cell_cycle1.26306074
61MP0002233_abnormal_nose_morphology1.25303064
62MP0003121_genomic_imprinting1.23997430
63MP0000604_amyloidosis1.22060580
64MP0003861_abnormal_nervous_system1.21974328
65MP0003890_abnormal_embryonic-extraembry1.21445606
66MP0001286_abnormal_eye_development1.20613451
67MP0004084_abnormal_cardiac_muscle1.20189295
68MP0002796_impaired_skin_barrier1.19885491
69MP0002734_abnormal_mechanical_nocicepti1.19460479
70MP0005499_abnormal_olfactory_system1.19404239
71MP0005394_taste/olfaction_phenotype1.19404239
72MP0005166_decreased_susceptibility_to1.19009586
73MP0003091_abnormal_cell_migration1.16386211
74MP0003252_abnormal_bile_duct1.14387045
75MP0001299_abnormal_eye_distance/1.11563768
76MP0002751_abnormal_autonomic_nervous1.10240772
77MP0010678_abnormal_skin_adnexa1.09295089
78MP0000647_abnormal_sebaceous_gland1.07030940
79MP0002088_abnormal_embryonic_growth/wei1.06491399
80MP0002092_abnormal_eye_morphology1.04709288
81MP0003984_embryonic_growth_retardation1.02596150
82MP0002086_abnormal_extraembryonic_tissu1.01566544
83MP0002102_abnormal_ear_morphology1.01560053
84MP0003122_maternal_imprinting0.99561002
85MP0009840_abnormal_foam_cell0.98622007
86MP0004811_abnormal_neuron_physiology0.98563395
87MP0006035_abnormal_mitochondrial_morpho0.97865753
88MP0001672_abnormal_embryogenesis/_devel0.97599908
89MP0005380_embryogenesis_phenotype0.97599908
90MP0005257_abnormal_intraocular_pressure0.96959849
91MP0000579_abnormal_nail_morphology0.96849442
92MP0002089_abnormal_postnatal_growth/wei0.95370902
93MP0008789_abnormal_olfactory_epithelium0.95138412
94MP0002111_abnormal_tail_morphology0.95095242
95MP0008961_abnormal_basal_metabolism0.93544394
96MP0003755_abnormal_palate_morphology0.92174396
97MP0005501_abnormal_skin_physiology0.91464790
98MP0001849_ear_inflammation0.90891908
99MP0000358_abnormal_cell_content/0.90034567
100MP0003787_abnormal_imprinting0.89872146
101MP0005220_abnormal_exocrine_pancreas0.89388596
102MP0004133_heterotaxia0.89137923
103MP0000383_abnormal_hair_follicle0.88436864
104MP0004197_abnormal_fetal_growth/weight/0.87794283
105MP0001881_abnormal_mammary_gland0.87065874
106MP0008875_abnormal_xenobiotic_pharmacok0.86376216
107MP0001542_abnormal_bone_strength0.86035350
108MP0000313_abnormal_cell_death0.85655019
109* MP0002081_perinatal_lethality0.85435376
110MP0001697_abnormal_embryo_size0.84863651
111MP0005621_abnormal_cell_physiology0.84844097
112MP0000013_abnormal_adipose_tissue0.82720495
113MP0005248_abnormal_Harderian_gland0.82132101
114MP0001663_abnormal_digestive_system0.81943930
115MP0002735_abnormal_chemical_nociception0.80602747
116MP0000465_gastrointestinal_hemorrhage0.80497985
117MP0003718_maternal_effect0.80088867
118MP0003935_abnormal_craniofacial_develop0.79991417
119MP0001756_abnormal_urination0.79333281
120MP0008260_abnormal_autophagy0.78910164
121MP0005084_abnormal_gallbladder_morpholo0.78461036
122MP0002080_prenatal_lethality0.78428031
123MP0002090_abnormal_vision0.77264548
124MP0010368_abnormal_lymphatic_system0.76990082
125MP0002972_abnormal_cardiac_muscle0.76830234
126MP0008007_abnormal_cellular_replicative0.76523418
127MP0000432_abnormal_head_morphology0.73485956
128MP0002063_abnormal_learning/memory/cond0.73389772
129MP0000609_abnormal_liver_physiology0.72994278
130MP0006276_abnormal_autonomic_nervous0.72743189
131MP0001915_intracranial_hemorrhage0.70808017
132MP0002152_abnormal_brain_morphology0.70780225
133MP0003566_abnormal_cell_adhesion0.70621120
134MP0004233_abnormal_muscle_weight0.69883521
135MP0004957_abnormal_blastocyst_morpholog0.68280582
136MP0002009_preneoplasia0.67686403
137MP0003115_abnormal_respiratory_system0.67645903
138MP0005384_cellular_phenotype0.67454851
139MP0002653_abnormal_ependyma_morphology0.67076704
140MP0000955_abnormal_spinal_cord0.66583758
141MP0003385_abnormal_body_wall0.65363925
142MP0009384_cardiac_valve_regurgitation0.64162552
143MP0003329_amyloid_beta_deposits0.62528017
144MP0003119_abnormal_digestive_system0.61374700
145MP0000778_abnormal_nervous_system0.60692788
146MP0004484_altered_response_of0.60318962
147MP0003567_abnormal_fetal_cardiomyocyte0.60107973
148MP0004858_abnormal_nervous_system0.60099205
149MP0002133_abnormal_respiratory_system0.57501856
150MP0005388_respiratory_system_phenotype0.57501856
151MP0003448_altered_tumor_morphology0.55251974
152MP0005646_abnormal_pituitary_gland0.55179829

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)3.86158422
2Subacute progressive viral hepatitis (HP:0006572)3.77071579
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.67492255
4Medulloblastoma (HP:0002885)3.59606389
5Cortical dysplasia (HP:0002539)3.58918638
6Neoplasm of the adrenal cortex (HP:0100641)3.33134299
7Rhinitis (HP:0012384)3.24790045
8Ependymoma (HP:0002888)3.23693349
9Papillary thyroid carcinoma (HP:0002895)3.21429096
10Cupped ribs (HP:0000887)3.04817864
11Nephroblastoma (Wilms tumor) (HP:0002667)3.02855455
12Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.97058419
13Asymmetry of the thorax (HP:0001555)2.96042267
14Rhabdomyosarcoma (HP:0002859)2.94666519
15Papilledema (HP:0001085)2.93940913
16Abnormal respiratory motile cilium physiology (HP:0012261)2.85362478
17Embryonal renal neoplasm (HP:0011794)2.81137793
18Enlarged penis (HP:0000040)2.71174874
19Urinary urgency (HP:0000012)2.70853907
20Abnormal respiratory epithelium morphology (HP:0012253)2.70719919
21Abnormal respiratory motile cilium morphology (HP:0005938)2.70719919
22Irregular epiphyses (HP:0010582)2.69754858
23Shoulder girdle muscle weakness (HP:0003547)2.68558855
24Gastrointestinal carcinoma (HP:0002672)2.59906608
25Malignant gastrointestinal tract tumors (HP:0006749)2.59906608
26Abnormal ciliary motility (HP:0012262)2.59886893
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59341034
28Stillbirth (HP:0003826)2.58931703
29Agnosia (HP:0010524)2.58273948
30Colon cancer (HP:0003003)2.58163300
31Hepatoblastoma (HP:0002884)2.54526673
32Biliary tract neoplasm (HP:0100574)2.53833961
33Disinhibition (HP:0000734)2.53544798
34Abnormal foot bone ossification (HP:0010675)2.51339943
35Thyroid carcinoma (HP:0002890)2.50789333
36Epiphyseal dysplasia (HP:0002656)2.45959703
37Poikilocytosis (HP:0004447)2.41711335
38Mutism (HP:0002300)2.40980333
39Multiple enchondromatosis (HP:0005701)2.40958224
40Curly hair (HP:0002212)2.39261143
41Pelvic girdle muscle weakness (HP:0003749)2.38955678
42Glioma (HP:0009733)2.36747367
43Abnormality of the astrocytes (HP:0100707)2.36440781
44Astrocytoma (HP:0009592)2.36440781
45Chromsome breakage (HP:0040012)2.34807189
46Termporal pattern (HP:0011008)2.32059113
47Insidious onset (HP:0003587)2.32059113
48Absent frontal sinuses (HP:0002688)2.29602448
49Leiomyosarcoma (HP:0100243)2.28486305
50Uterine leiomyosarcoma (HP:0002891)2.28486305
51Abnormal lung lobation (HP:0002101)2.28133542
52Metaphyseal cupping (HP:0003021)2.27715560
53Acanthocytosis (HP:0001927)2.27283803
54Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.24814490
55Impaired vibration sensation in the lower limbs (HP:0002166)2.24201000
56Wrist flexion contracture (HP:0001239)2.23612553
57Increased nuchal translucency (HP:0010880)2.23293985
58Breast carcinoma (HP:0003002)2.20094095
59Hyperglycemia (HP:0003074)2.20009124
60Vitreoretinal degeneration (HP:0000655)2.19461595
61Uterine neoplasm (HP:0010784)2.18872196
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.17815214
63Absent/shortened dynein arms (HP:0200106)2.17815214
64Stenosis of the external auditory canal (HP:0000402)2.14105815
65Progressive external ophthalmoplegia (HP:0000590)2.13674565
66Bronchiectasis (HP:0002110)2.11332226
67Birth length less than 3rd percentile (HP:0003561)2.09218373
68Absent eyebrow (HP:0002223)2.08390185
69Hypochromic microcytic anemia (HP:0004840)2.05962092
70Carpal bone hypoplasia (HP:0001498)2.05599632
71Abnormality of chromosome stability (HP:0003220)2.04230056
72Inappropriate behavior (HP:0000719)2.03708663
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02319851
74Absent epiphyses (HP:0010577)2.02319851
75Postnatal microcephaly (HP:0005484)2.02170396
76Abnormality of the musculature of the pelvis (HP:0001469)2.01746120
77Abnormality of the hip-girdle musculature (HP:0001445)2.01746120
78Akinesia (HP:0002304)2.01740629
79Amyotrophic lateral sclerosis (HP:0007354)2.01624683
80Viral hepatitis (HP:0006562)2.01391717
81Abnormality of the lower motor neuron (HP:0002366)1.97834584
82Neoplasm of the adrenal gland (HP:0100631)1.97311033
83Lower limb asymmetry (HP:0100559)1.95587497
84Ileus (HP:0002595)1.95027519
85Submucous cleft hard palate (HP:0000176)1.94987010
86Hepatocellular carcinoma (HP:0001402)1.94271461
87Tetraplegia (HP:0002445)1.93889899
88Meckel diverticulum (HP:0002245)1.92303285
89Neuroblastoma (HP:0003006)1.91618748
90Primitive neuroectodermal tumor (HP:0030065)1.91618748
91Neuroblastic tumors (HP:0004376)1.91618748
92Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.91618748
93Aqueductal stenosis (HP:0002410)1.90393631
94Small epiphyses (HP:0010585)1.89579106
95Neoplasm of the small intestine (HP:0100833)1.88361834
96Upper limb muscle weakness (HP:0003484)1.87511713
97Posterior subcapsular cataract (HP:0007787)1.87343315
98Thoracolumbar scoliosis (HP:0002944)1.87251104
99Cystic hygroma (HP:0000476)1.87187656
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86674857
101Transitional cell carcinoma of the bladder (HP:0006740)1.85902878
102Reticulocytosis (HP:0001923)1.84785516
103Macroorchidism (HP:0000053)1.83824986
104Atrophy/Degeneration involving motor neurons (HP:0007373)1.83549185
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83396233
106Entropion (HP:0000621)1.80874383
107Relative macrocephaly (HP:0004482)1.80116381
108Neoplasm of the colon (HP:0100273)1.80011714
109Cervical subluxation (HP:0003308)1.79857824
110Gout (HP:0001997)1.79446723
111Abnormality of the ileum (HP:0001549)1.79096365
112Conjunctival telangiectasia (HP:0000524)1.78642007
113Generalized hypotonia (HP:0001290)1.77368549
114Increased density of long bones (HP:0006392)1.75970497
115Drooling (HP:0002307)1.74943931
116Excessive salivation (HP:0003781)1.74943931
117Myocardial infarction (HP:0001658)1.74904905
118Hammertoe (HP:0001765)1.74866062
119Exostoses (HP:0100777)1.74313246
120Limb-girdle muscle atrophy (HP:0003797)1.74053679
121Failure to thrive in infancy (HP:0001531)1.73839795
122Myelomeningocele (HP:0002475)1.73680747
123Embryonal neoplasm (HP:0002898)1.73632228
124Abnormality of the lumbar spine (HP:0100712)1.73586031
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.73545933
126Broad foot (HP:0001769)1.73450757
127Spastic gait (HP:0002064)1.70550578
128Osteolytic defects of the phalanges of the hand (HP:0009771)1.70258233
129Osteolytic defects of the hand bones (HP:0009699)1.70258233
130Neoplasm of striated muscle (HP:0009728)1.70207646
131Choanal stenosis (HP:0000452)1.69958765
132Freckling (HP:0001480)1.69801015
133Tetraparesis (HP:0002273)1.69115203
134Long clavicles (HP:0000890)1.68679337
135Severe short stature (HP:0003510)1.68600281
136Pheochromocytoma (HP:0002666)1.68471076
137Neoplasm of the thyroid gland (HP:0100031)1.68323401
138Ovarian neoplasm (HP:0100615)1.68076917
139Abdominal situs inversus (HP:0003363)1.68039484
140Abnormality of abdominal situs (HP:0011620)1.68039484
141Spastic diplegia (HP:0001264)1.67441708
142Protruding tongue (HP:0010808)1.66756169
143Deep philtrum (HP:0002002)1.66727507
144Selective tooth agenesis (HP:0001592)1.66027682
145Progressive sensorineural hearing impairment (HP:0000408)1.65876129
146Vaginal atresia (HP:0000148)1.65545953
147Bifid tongue (HP:0010297)1.64278739
148Cutaneous melanoma (HP:0012056)1.63886126
149Omphalocele (HP:0001539)1.63218806
150Small intestinal stenosis (HP:0012848)1.63035953
151Duodenal stenosis (HP:0100867)1.63035953
152Long toe (HP:0010511)1.62908735
153Abnormality of the labia minora (HP:0012880)1.62468453
154Exercise-induced muscle cramps (HP:0003710)1.61836348
155Bladder carcinoma (HP:0002862)1.61831367
156Bladder neoplasm (HP:0009725)1.61831367
157Meningioma (HP:0002858)1.61456478
158Spinal cord lesions (HP:0100561)1.60795878
159Syringomyelia (HP:0003396)1.60795878
160Hematochezia (HP:0002573)1.59577632
161Mucosal telangiectasiae (HP:0100579)1.58448116
162Abnormal tarsal ossification (HP:0008369)1.58305662
163Apathy (HP:0000741)1.57965444
164Lower limb amyotrophy (HP:0007210)1.57757578
165Hypobetalipoproteinemia (HP:0003563)1.57551054
166Hypoplastic ischia (HP:0003175)1.55744894
167Abnormal biliary tract morphology (HP:0012440)1.55712558
168Facial hemangioma (HP:0000329)1.55569402
169Lymphangioma (HP:0100764)1.54791133
170Arthropathy (HP:0003040)1.52782261
171Increased CSF protein (HP:0002922)1.52565344
172Volvulus (HP:0002580)1.52516069
173Resting tremor (HP:0002322)1.51019335
174Segmental peripheral demyelination/remyelination (HP:0003481)1.50580607
175Flat acetabular roof (HP:0003180)1.49836890
176Abnormal pancreas size (HP:0012094)1.49369300
177Hypolipoproteinemia (HP:0010981)1.48269101
178Abnormality of chromosome segregation (HP:0002916)1.48260716
179Disproportionate short-trunk short stature (HP:0003521)1.48085038
180Spinal cord compression (HP:0002176)1.47806526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.40353886
2BCR4.15035304
3TRIM283.94489900
4MARK13.82595410
5SCYL23.24206801
6NEK12.83331367
7MST42.61722041
8ERBB32.56184038
9CCNB12.26395276
10EIF2AK12.23274490
11PLK32.16390040
12SIK32.15286175
13LMTK22.08349051
14TNIK2.00839690
15TSSK61.96183835
16LATS11.87259238
17STK241.86647802
18CASK1.81993563
19PBK1.75330928
20MAP3K41.65590424
21CDC71.63311257
22BRSK11.62354435
23AKT31.61548361
24PLK21.56357844
25MAP3K91.56192333
26LATS21.55265075
27PKN21.54797327
28MAP3K21.54072121
29KSR21.52790091
30BRSK21.52072746
31KSR11.49724751
32BRD41.44617067
33RPS6KA41.42074738
34SGK21.38582081
35STK31.34262463
36PDK21.31772561
37MAP3K31.27759788
38MINK11.27036869
39RIPK11.26062245
40SGK31.24688727
41CAMKK11.21645362
42MKNK21.20779441
43TAF11.19948152
44TRIB31.17357336
45ERBB41.16666954
46TESK11.16227076
47NEK21.16186816
48LIMK11.16164674
49NUAK11.15933388
50PLK41.14523423
51STK101.13452056
52DYRK1A1.09159262
53FGFR21.02831060
54TAOK20.95806102
55CSNK1G10.94970714
56MAP3K50.94591242
57WEE10.94164429
58MAP3K80.92727393
59TAOK10.91244087
60PDK40.90852858
61PDK30.90852858
62EPHA20.90404733
63CSNK1G30.90286202
64FGFR30.90099222
65YES10.88448599
66MAP3K100.88025619
67DYRK30.84879635
68CAMKK20.83946311
69PAK40.83356038
70RET0.79993393
71EIF2AK20.79621580
72ALK0.79426098
73PTK60.79338455
74MST1R0.79032198
75MAP2K10.78314724
76TAOK30.77532924
77DAPK20.72504193
78MAP3K140.72146911
79CSNK1G20.70906494
80MKNK10.70743660
81PAK60.70292928
82RPS6KA20.70181242
83PDGFRA0.67793962
84STK38L0.66823067
85WNK30.66701262
86CSNK1A1L0.64369120
87PNCK0.62967560
88SGK2230.62791506
89SGK4940.62791506
90MAPK130.62188452
91PAK30.61983496
92CDK190.61622794
93CHEK10.61508896
94FGFR10.61211483
95PASK0.60911939
96CDK60.60792408
97MAP2K70.60749197
98PRKAA10.59958279
99MET0.58449812
100PLK10.56967967
101NEK60.56614223
102EPHA30.56225318
103ZAK0.54966649
104ACVR1B0.54383577
105NTRK10.53434654
106ATR0.53402743
107AURKB0.51680391
108MAP2K40.51547704
109RPS6KB10.51035451
110NEK90.50217448
111CDK11A0.48411093
112BUB10.47254097
113DYRK20.47036660
114VRK10.44582120
115CSNK1E0.43807846
116EEF2K0.43403611
117CHEK20.43330585
118TTK0.42817327
119MARK30.42519808
120CDK140.41793283
121CDK150.40596009
122EGFR0.40249058
123EIF2AK30.39853753
124CDK180.39463725
125CDK10.39078908
126MAP3K60.38366717
127PIK3CA0.37423190
128SRPK10.37270502
129RAF10.37235044
130SMG10.37089533
131PRKDC0.36468971
132MELK0.36322927
133FGR0.36018906
134UHMK10.35892016
135EPHA40.34932202
136PRKCI0.34727799
137CDK20.34543059
138MAPK120.34401976
139CDK70.34383764
140PRKG20.34074386
141CDK50.33904670
142RPS6KB20.33625195
143ATM0.32180438
144AKT20.29805935
145PRKCE0.28399818
146FER0.27949578
147MAPK100.26830640
148OXSR10.26487654
149AURKA0.25361335
150CSNK1D0.24452803

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.18787654
2Mismatch repair_Homo sapiens_hsa034302.92846065
3DNA replication_Homo sapiens_hsa030302.50929288
4Spliceosome_Homo sapiens_hsa030402.32636540
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22496159
6mRNA surveillance pathway_Homo sapiens_hsa030152.19915866
7Vitamin B6 metabolism_Homo sapiens_hsa007502.12537207
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03546774
9Steroid biosynthesis_Homo sapiens_hsa001001.90250414
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85938767
11Endometrial cancer_Homo sapiens_hsa052131.78205552
12Nitrogen metabolism_Homo sapiens_hsa009101.71351751
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.64327061
14Cell cycle_Homo sapiens_hsa041101.63998082
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62882264
16mTOR signaling pathway_Homo sapiens_hsa041501.58623371
17Protein export_Homo sapiens_hsa030601.58369746
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.57871155
19Base excision repair_Homo sapiens_hsa034101.56854736
20Nucleotide excision repair_Homo sapiens_hsa034201.56235926
21Mineral absorption_Homo sapiens_hsa049781.49323044
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49042477
23Oocyte meiosis_Homo sapiens_hsa041141.45868827
24Basal transcription factors_Homo sapiens_hsa030221.45797286
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.44358732
26Glioma_Homo sapiens_hsa052141.44223466
27RNA degradation_Homo sapiens_hsa030181.44125288
28Circadian rhythm_Homo sapiens_hsa047101.40692991
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37569411
30Tight junction_Homo sapiens_hsa045301.34971879
31Proteasome_Homo sapiens_hsa030501.34164611
32Hippo signaling pathway_Homo sapiens_hsa043901.30916256
33Renin-angiotensin system_Homo sapiens_hsa046141.30065901
34Colorectal cancer_Homo sapiens_hsa052101.27084806
35Fat digestion and absorption_Homo sapiens_hsa049751.24436475
36FoxO signaling pathway_Homo sapiens_hsa040681.22394070
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21040720
38Type II diabetes mellitus_Homo sapiens_hsa049301.20120472
39Pancreatic cancer_Homo sapiens_hsa052121.17785110
40Renal cell carcinoma_Homo sapiens_hsa052111.14183016
41Carbon metabolism_Homo sapiens_hsa012001.12794394
42Synaptic vesicle cycle_Homo sapiens_hsa047211.10944637
43Starch and sucrose metabolism_Homo sapiens_hsa005001.09410805
44Nicotine addiction_Homo sapiens_hsa050331.08583310
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08287759
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08114570
47Long-term potentiation_Homo sapiens_hsa047201.07829351
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06873833
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06319184
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05600855
51Chronic myeloid leukemia_Homo sapiens_hsa052201.03008353
52Pyruvate metabolism_Homo sapiens_hsa006201.02787149
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01962968
54p53 signaling pathway_Homo sapiens_hsa041151.01807069
55Vitamin digestion and absorption_Homo sapiens_hsa049771.00998850
56Fanconi anemia pathway_Homo sapiens_hsa034600.99356492
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95716831
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.94740972
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94173008
60Prostate cancer_Homo sapiens_hsa052150.93799969
61Propanoate metabolism_Homo sapiens_hsa006400.93000417
62Dorso-ventral axis formation_Homo sapiens_hsa043200.92956711
63Non-small cell lung cancer_Homo sapiens_hsa052230.92930914
64Estrogen signaling pathway_Homo sapiens_hsa049150.92815967
65Bile secretion_Homo sapiens_hsa049760.92227807
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.92224183
67Vibrio cholerae infection_Homo sapiens_hsa051100.90122189
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90118798
69Arginine biosynthesis_Homo sapiens_hsa002200.89834877
70Prolactin signaling pathway_Homo sapiens_hsa049170.85145778
71Galactose metabolism_Homo sapiens_hsa000520.83803006
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.83244343
73Viral myocarditis_Homo sapiens_hsa054160.82411673
74Insulin resistance_Homo sapiens_hsa049310.82336213
75Insulin signaling pathway_Homo sapiens_hsa049100.81345654
76Gap junction_Homo sapiens_hsa045400.81258426
77Hepatitis B_Homo sapiens_hsa051610.80983447
78beta-Alanine metabolism_Homo sapiens_hsa004100.80156067
79Legionellosis_Homo sapiens_hsa051340.80054029
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79458361
81MicroRNAs in cancer_Homo sapiens_hsa052060.78674377
82Protein digestion and absorption_Homo sapiens_hsa049740.77660519
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76534744
84One carbon pool by folate_Homo sapiens_hsa006700.75336076
85Adherens junction_Homo sapiens_hsa045200.73923262
86ErbB signaling pathway_Homo sapiens_hsa040120.73874913
87TGF-beta signaling pathway_Homo sapiens_hsa043500.72094629
88Small cell lung cancer_Homo sapiens_hsa052220.71481501
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70822915
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69665259
91Focal adhesion_Homo sapiens_hsa045100.69482630
92Apoptosis_Homo sapiens_hsa042100.68769047
93Olfactory transduction_Homo sapiens_hsa047400.68089018
94Shigellosis_Homo sapiens_hsa051310.68072954
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68059704
96RNA transport_Homo sapiens_hsa030130.67837049
97Dopaminergic synapse_Homo sapiens_hsa047280.67299469
98Viral carcinogenesis_Homo sapiens_hsa052030.66535712
99RNA polymerase_Homo sapiens_hsa030200.65523247
100Butanoate metabolism_Homo sapiens_hsa006500.64952808
101Thyroid hormone synthesis_Homo sapiens_hsa049180.64610212
102Fatty acid elongation_Homo sapiens_hsa000620.63487575
103Selenocompound metabolism_Homo sapiens_hsa004500.63152292
104GABAergic synapse_Homo sapiens_hsa047270.63094294
105Wnt signaling pathway_Homo sapiens_hsa043100.62634603
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61758562
107GnRH signaling pathway_Homo sapiens_hsa049120.61637580
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60753048
109Amphetamine addiction_Homo sapiens_hsa050310.60581093
110Antigen processing and presentation_Homo sapiens_hsa046120.59380214
111Bladder cancer_Homo sapiens_hsa052190.59136350
112Thyroid cancer_Homo sapiens_hsa052160.59122473
113AMPK signaling pathway_Homo sapiens_hsa041520.58144421
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57774603
115Toxoplasmosis_Homo sapiens_hsa051450.57447430
116Glutathione metabolism_Homo sapiens_hsa004800.57383701
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57097079
118TNF signaling pathway_Homo sapiens_hsa046680.56935435
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55904868
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55367705
121Pyrimidine metabolism_Homo sapiens_hsa002400.54908614
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54850869
123Axon guidance_Homo sapiens_hsa043600.54280427
124Alcoholism_Homo sapiens_hsa050340.54060883
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54033021
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53862135
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53836448
128Phagosome_Homo sapiens_hsa041450.53643534
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53540172
130HIF-1 signaling pathway_Homo sapiens_hsa040660.53526315
131Regulation of autophagy_Homo sapiens_hsa041400.53339995
132Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53105342
133Sphingolipid metabolism_Homo sapiens_hsa006000.52573447
134Proteoglycans in cancer_Homo sapiens_hsa052050.52056833
135Glucagon signaling pathway_Homo sapiens_hsa049220.51375169
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50444379
137Purine metabolism_Homo sapiens_hsa002300.50130307
138Biosynthesis of amino acids_Homo sapiens_hsa012300.49877521
139Influenza A_Homo sapiens_hsa051640.48812092
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48749880
141Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48098424
142Inositol phosphate metabolism_Homo sapiens_hsa005620.48067103
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48031917
144Long-term depression_Homo sapiens_hsa047300.47790627
145Melanoma_Homo sapiens_hsa052180.47656285
146Sulfur metabolism_Homo sapiens_hsa009200.47054892
147Circadian entrainment_Homo sapiens_hsa047130.46955306
148Hepatitis C_Homo sapiens_hsa051600.46823989
149Pentose phosphate pathway_Homo sapiens_hsa000300.45065133
150Epstein-Barr virus infection_Homo sapiens_hsa051690.38176523
151Homologous recombination_Homo sapiens_hsa034400.38027633
152Arginine and proline metabolism_Homo sapiens_hsa003300.37898016
153Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37439768
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36521915
155N-Glycan biosynthesis_Homo sapiens_hsa005100.35359201
156Fatty acid biosynthesis_Homo sapiens_hsa000610.31846892
157Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31664949
158Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31454786
159Hedgehog signaling pathway_Homo sapiens_hsa043400.29694670

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