AZIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)8.26296320
2sperm motility (GO:0030317)7.97318992
3cell wall macromolecule catabolic process (GO:0016998)7.63948621
4cell wall macromolecule metabolic process (GO:0044036)7.63948621
5fusion of sperm to egg plasma membrane (GO:0007342)7.18413642
6acrosome assembly (GO:0001675)6.50147654
7sperm-egg recognition (GO:0035036)5.94162003
8plasma membrane fusion (GO:0045026)5.79654448
9multicellular organism reproduction (GO:0032504)5.43527396
10binding of sperm to zona pellucida (GO:0007339)5.27902563
11cell-cell recognition (GO:0009988)5.25489505
12epithelial cilium movement (GO:0003351)5.21762036
13spermatid development (GO:0007286)5.21181342
14calcium ion-dependent exocytosis (GO:0017156)5.10414252
15regulation of cilium movement (GO:0003352)5.01773571
16reproduction (GO:0000003)4.93355772
17motile cilium assembly (GO:0044458)4.90063784
18axonemal dynein complex assembly (GO:0070286)4.83156122
19negative regulation of inclusion body assembly (GO:0090084)4.61158734
20cilium movement (GO:0003341)4.47034970
21cilium or flagellum-dependent cell motility (GO:0001539)4.41289060
22postsynaptic membrane organization (GO:0001941)4.29435324
23microtubule nucleation (GO:0007020)4.28607958
24regulation of inclusion body assembly (GO:0090083)4.07239448
25neuronal ion channel clustering (GO:0045161)4.01202494
26synaptonemal complex organization (GO:0070193)3.98920136
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.93021208
28sodium ion export (GO:0071436)3.85220480
29sperm capacitation (GO:0048240)3.82917194
30synaptonemal complex assembly (GO:0007130)3.78615850
31single fertilization (GO:0007338)3.64865547
32* spermatogenesis (GO:0007283)3.64714749
33* male gamete generation (GO:0048232)3.62598216
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61187905
35regulation of microtubule-based movement (GO:0060632)3.60380866
36negative regulation of catenin import into nucleus (GO:0035414)3.58269448
37membrane depolarization during action potential (GO:0086010)3.55062898
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54723575
39left/right pattern formation (GO:0060972)3.51446486
40regulation of plasminogen activation (GO:0010755)3.40342731
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35743376
42positive regulation of membrane potential (GO:0045838)3.34341809
43cochlea development (GO:0090102)3.33833011
44* gamete generation (GO:0007276)3.30385689
45male meiosis (GO:0007140)3.28744298
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.28204759
47axon ensheathment in central nervous system (GO:0032291)3.24122463
48central nervous system myelination (GO:0022010)3.24122463
49synaptic vesicle maturation (GO:0016188)3.23737892
50positive regulation of synapse maturation (GO:0090129)3.22223290
51cell recognition (GO:0008037)3.19915405
52sexual reproduction (GO:0019953)3.17755085
53cell migration in hindbrain (GO:0021535)3.17671637
54microtubule severing (GO:0051013)3.17599095
55chromosome condensation (GO:0030261)3.13661644
56glutamate secretion (GO:0014047)3.08154022
57synaptic vesicle exocytosis (GO:0016079)3.07292348
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.07064240
59regulation of synaptic vesicle exocytosis (GO:2000300)3.05099953
60ventricular system development (GO:0021591)3.04095556
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03665433
62fertilization (GO:0009566)3.02944126
63regulation of protein kinase A signaling (GO:0010738)3.02611105
64cerebral cortex neuron differentiation (GO:0021895)3.01160714
65locomotory exploration behavior (GO:0035641)3.01072632
66positive regulation of endothelial cell differentiation (GO:0045603)2.99687070
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.99535365
68cellular process involved in reproduction in multicellular organism (GO:0022412)2.98108219
69microtubule depolymerization (GO:0007019)2.97181206
70piRNA metabolic process (GO:0034587)2.95642420
71synaptic vesicle docking involved in exocytosis (GO:0016081)2.95316245
72L-amino acid import (GO:0043092)2.94419193
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93052605
74regulation of synapse structural plasticity (GO:0051823)2.93040794
75behavioral defense response (GO:0002209)2.91874001
76behavioral fear response (GO:0001662)2.91874001
77proline transport (GO:0015824)2.90545245
78germ cell development (GO:0007281)2.89404263
79dendritic spine organization (GO:0097061)2.88039911
80regulation of synaptic plasticity (GO:0048167)2.87125154
81regulation of ARF protein signal transduction (GO:0032012)2.87014375
82cerebellar granule cell differentiation (GO:0021707)2.85465367
83cell communication by electrical coupling (GO:0010644)2.84856816
84peptidyl-proline hydroxylation (GO:0019511)2.84710089
85protein localization to synapse (GO:0035418)2.84415784
86DNA packaging (GO:0006323)2.84091570
87homocysteine metabolic process (GO:0050667)2.83415385
88regulation of synapse maturation (GO:0090128)2.81015241
89neurotransmitter-gated ion channel clustering (GO:0072578)2.79405391
90long-term memory (GO:0007616)2.77293336
91neuronal action potential propagation (GO:0019227)2.76687494
92vocalization behavior (GO:0071625)2.75919581
93protein polyglutamylation (GO:0018095)2.75728232
94* organic cation transport (GO:0015695)2.75634448
95amino acid import (GO:0043090)2.75393871
96positive regulation of dendritic spine development (GO:0060999)2.74151976
97neurotransmitter transport (GO:0006836)2.73975171
98regulation of synaptic vesicle transport (GO:1902803)2.73553069
99urinary tract smooth muscle contraction (GO:0014848)2.73353414
100negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72163664
101gamma-aminobutyric acid transport (GO:0015812)2.70652649
102protein localization to cilium (GO:0061512)2.69363607
103microtubule polymerization or depolymerization (GO:0031109)2.68568309
104regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66165326
105neurotransmitter secretion (GO:0007269)2.65260237
106response to acidic pH (GO:0010447)2.65230015
107single strand break repair (GO:0000012)2.64798047
108* multicellular organismal reproductive process (GO:0048609)2.64562802
109regulation of glutamate receptor signaling pathway (GO:1900449)2.62897319
110cytoskeletal anchoring at plasma membrane (GO:0007016)2.62518628
111cellular response to pH (GO:0071467)2.62168537
112sympathetic nervous system development (GO:0048485)2.62086900
113cranial nerve morphogenesis (GO:0021602)2.60518546
114neuromuscular process controlling balance (GO:0050885)2.59406077
115response to gravity (GO:0009629)2.59233749
116layer formation in cerebral cortex (GO:0021819)2.59097035
117sequestering of actin monomers (GO:0042989)2.58717486
118establishment of mitochondrion localization (GO:0051654)2.56570789
119neuromuscular synaptic transmission (GO:0007274)2.56543623
120fear response (GO:0042596)2.56158506
121acidic amino acid transport (GO:0015800)2.54140483
122spermatid nucleus differentiation (GO:0007289)2.53847668
123positive regulation of neurotransmitter secretion (GO:0001956)2.53493567
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53366897
125dendritic spine morphogenesis (GO:0060997)2.53229937
126regulation of transcription involved in cell fate commitment (GO:0060850)2.53087051
127regulation of voltage-gated calcium channel activity (GO:1901385)2.51261204
128regulation of neurotransmitter secretion (GO:0046928)2.50944121
129sulfur amino acid catabolic process (GO:0000098)2.50693163
130epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.50010495
131exploration behavior (GO:0035640)2.48796821
132positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48584833
133synaptic vesicle endocytosis (GO:0048488)2.46323433
134neurofilament cytoskeleton organization (GO:0060052)2.45828195
135cellular potassium ion homeostasis (GO:0030007)2.43314116
136behavioral response to nicotine (GO:0035095)2.42742584
137mating behavior (GO:0007617)2.42533688
138regulation of neuronal synaptic plasticity (GO:0048168)2.41304142
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.41297383
140regulation of neurotransmitter transport (GO:0051588)2.41242309
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.40758121
142synaptic transmission, glutamatergic (GO:0035249)2.36692201
143positive regulation of fibroblast migration (GO:0010763)2.36594094
144energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.35796262
145ATP hydrolysis coupled proton transport (GO:0015991)2.35796262
146positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35578684
147innervation (GO:0060384)2.34478454
148multicellular organismal development (GO:0007275)2.34160021
149membrane depolarization (GO:0051899)2.33081898
150ionotropic glutamate receptor signaling pathway (GO:0035235)2.31674484
151synaptic transmission, cholinergic (GO:0007271)2.31131825
152calcium ion import (GO:0070509)2.30387038
153positive regulation of macrophage activation (GO:0043032)2.28112205
154neuron cell-cell adhesion (GO:0007158)2.25297286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.69251827
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.42800907
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71744493
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31840501
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24871929
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.15270266
7REST_21632747_ChIP-Seq_MESCs_Mouse2.13848297
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03851524
9SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96004522
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.90607854
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.90607854
12EZH2_27294783_Chip-Seq_ESCs_Mouse1.90421880
13JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89720586
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89339317
15IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86974197
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81113092
17LXR_22292898_ChIP-Seq_THP-1_Human1.79858430
18GBX2_23144817_ChIP-Seq_PC3_Human1.79849492
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79426154
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.77503092
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75979351
22DROSHA_22980978_ChIP-Seq_HELA_Human1.74367000
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.72455221
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72425783
25JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71761218
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71161191
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.68645921
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60049214
29ZNF274_21170338_ChIP-Seq_K562_Hela1.57257417
30DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55955743
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55491015
32E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55226766
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53119385
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51500822
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48686810
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.43324123
37VDR_22108803_ChIP-Seq_LS180_Human1.41261736
38P68_20966046_ChIP-Seq_HELA_Human1.36842821
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.34509221
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.32633494
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31171527
42RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29397166
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28633074
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28365406
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27468731
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27410602
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.26424817
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23589256
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.22236284
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20482949
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.19629129
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19004539
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17007385
54SMAD4_21799915_ChIP-Seq_A2780_Human1.15587370
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15354713
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.12121039
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10533506
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10472432
59KDM2B_26808549_Chip-Seq_REH_Human1.10066923
60TP63_22573176_ChIP-Seq_HFKS_Human1.09108041
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08598351
62CTCF_20526341_ChIP-Seq_ESCs_Human1.07929548
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07534523
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06713819
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06424306
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05543406
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05282249
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04961569
69CTCF_27219007_Chip-Seq_Bcells_Human1.04129036
70TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03179232
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02490453
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02117516
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01126363
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00281509
75OCT4_19829295_ChIP-Seq_ESCs_Human1.00235804
76PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99990490
77SMAD3_21741376_ChIP-Seq_ESCs_Human0.99695668
78RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97618747
79ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97461606
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97323135
81TET1_21490601_ChIP-Seq_MESCs_Mouse0.96852630
82AR_25329375_ChIP-Seq_VCAP_Human0.95861129
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95674897
84ELF1_20517297_ChIP-Seq_JURKAT_Human0.94860038
85TP53_18474530_ChIP-ChIP_U2OS_Human0.94222070
86NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93685480
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93552923
88EP300_21415370_ChIP-Seq_HL-1_Mouse0.93547975
89KDM2B_26808549_Chip-Seq_K562_Human0.93329005
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.92133327
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91831161
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91616344
93SMC4_20622854_ChIP-Seq_HELA_Human0.91410570
94TP53_20018659_ChIP-ChIP_R1E_Mouse0.90994240
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90878907
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.90776132
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90362907
98AHR_22903824_ChIP-Seq_MCF-7_Human0.90177000
99RNF2_27304074_Chip-Seq_NSC_Mouse0.89165734
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88991173
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88915929
102CBP_20019798_ChIP-Seq_JUKART_Human0.88785698
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88785698
104GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.88227744
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.87851142
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87714125
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87175149
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87175149
109AR_19668381_ChIP-Seq_PC3_Human0.86937510
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86448431
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86362425
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.86253595
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86161874
114SA1_27219007_Chip-Seq_Bcells_Human0.85892683
115BCOR_27268052_Chip-Seq_Bcells_Human0.85881074
116RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85520431
117RING1B_27294783_Chip-Seq_NPCs_Mouse0.85452634
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85045952
119BCL6_27268052_Chip-Seq_Bcells_Human0.84926782
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83788677
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83715436
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83477087
123ARNT_22903824_ChIP-Seq_MCF-7_Human0.83212052
124TP53_22127205_ChIP-Seq_IMR90_Human0.83144027
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83043441
126YY1_22570637_ChIP-Seq_MALME-3M_Human0.82749834
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.82651808
128TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82396449
129MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82211913
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81794594
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.81660836
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81420981
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81410353
134SMAD4_21741376_ChIP-Seq_ESCs_Human0.81269371
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81028031
136TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80753259
137AR_21572438_ChIP-Seq_LNCaP_Human0.80492890
138KLF4_19829295_ChIP-Seq_ESCs_Human0.80455901
139JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78837475
140OCT4_20526341_ChIP-Seq_ESCs_Human0.78763926
141SOX2_21211035_ChIP-Seq_LN229_Gbm0.78345023
142SA1_27219007_Chip-Seq_ERYTHROID_Human0.78311783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.71411967
2MP0004859_abnormal_synaptic_plasticity3.48865981
3MP0004858_abnormal_nervous_system3.27712077
4MP0001968_abnormal_touch/_nociception3.03768291
5MP0002735_abnormal_chemical_nociception2.81075929
6MP0003698_abnormal_male_reproductive2.65725075
7MP0002736_abnormal_nociception_after2.63223700
8MP0005623_abnormal_meninges_morphology2.47663556
9MP0003635_abnormal_synaptic_transmissio2.45743693
10MP0009046_muscle_twitch2.43657118
11MP0002822_catalepsy2.40086589
12MP0008438_abnormal_cutaneous_collagen2.21085648
13MP0004270_analgesia2.17075168
14MP0003705_abnormal_hypodermis_morpholog2.07856702
15MP0002734_abnormal_mechanical_nocicepti2.05237796
16MP0001929_abnormal_gametogenesis2.02657279
17MP0009745_abnormal_behavioral_response1.96991781
18MP0002063_abnormal_learning/memory/cond1.94056993
19MP0002733_abnormal_thermal_nociception1.92313035
20MP0009780_abnormal_chondrocyte_physiolo1.86057054
21MP0003279_aneurysm1.84101074
22MP0010386_abnormal_urinary_bladder1.79888597
23MP0006276_abnormal_autonomic_nervous1.74501997
24MP0002653_abnormal_ependyma_morphology1.74444674
25MP0005503_abnormal_tendon_morphology1.65810597
26MP0001970_abnormal_pain_threshold1.65772690
27MP0002572_abnormal_emotion/affect_behav1.64046156
28MP0002064_seizures1.63831852
29MP0002638_abnormal_pupillary_reflex1.63038126
30MP0002909_abnormal_adrenal_gland1.60260343
31MP0001440_abnormal_grooming_behavior1.58982966
32MP0000920_abnormal_myelination1.58448480
33MP0003880_abnormal_central_pattern1.58331635
34MP0003787_abnormal_imprinting1.58008993
35MP0002272_abnormal_nervous_system1.57979513
36MP0008877_abnormal_DNA_methylation1.50521869
37MP0001348_abnormal_lacrimal_gland1.50278730
38MP0003045_fibrosis1.45736719
39MP0005645_abnormal_hypothalamus_physiol1.42938180
40MP0002184_abnormal_innervation1.37939350
41MP0004885_abnormal_endolymph1.37760024
42MP0002161_abnormal_fertility/fecundity1.37265280
43MP0005275_abnormal_skin_tensile1.36814639
44MP0000534_abnormal_ureter_morphology1.31957676
45MP0003690_abnormal_glial_cell1.30656698
46MP0004811_abnormal_neuron_physiology1.29792619
47MP0005377_hearing/vestibular/ear_phenot1.29690700
48MP0003878_abnormal_ear_physiology1.29690700
49MP0001501_abnormal_sleep_pattern1.27840290
50MP0003329_amyloid_beta_deposits1.27650349
51MP0001984_abnormal_olfaction1.27307612
52MP0001963_abnormal_hearing_physiology1.27081782
53MP0000003_abnormal_adipose_tissue1.26016217
54MP0005670_abnormal_white_adipose1.25327900
55MP0009384_cardiac_valve_regurgitation1.23670937
56MP0002067_abnormal_sensory_capabilities1.22211447
57MP0001958_emphysema1.21468967
58MP0002229_neurodegeneration1.20495897
59MP0000955_abnormal_spinal_cord1.18573646
60MP0003183_abnormal_peptide_metabolism1.18223719
61MP0003942_abnormal_urinary_system1.17984777
62MP0004233_abnormal_muscle_weight1.15205169
63MP0005167_abnormal_blood-brain_barrier1.15114942
64MP0002160_abnormal_reproductive_system1.13694044
65MP0000678_abnormal_parathyroid_gland1.11802916
66MP0002295_abnormal_pulmonary_circulatio1.10721987
67MP0000026_abnormal_inner_ear1.09323077
68MP0008569_lethality_at_weaning1.08786815
69MP0003879_abnormal_hair_cell1.08725757
70MP0002557_abnormal_social/conspecific_i1.08378320
71MP0003283_abnormal_digestive_organ1.08261166
72MP0002210_abnormal_sex_determination1.07370324
73MP0001177_atelectasis1.05587018
74MP0005551_abnormal_eye_electrophysiolog1.05093472
75MP0001502_abnormal_circadian_rhythm1.04942598
76MP0001486_abnormal_startle_reflex1.04879794
77MP0002249_abnormal_larynx_morphology1.02049655
78MP0000749_muscle_degeneration1.01951819
79MP0000569_abnormal_digit_pigmentation1.01780537
80MP0002882_abnormal_neuron_morphology0.97987781
81MP0002751_abnormal_autonomic_nervous0.92520000
82MP0001299_abnormal_eye_distance/0.91048095
83MP0001485_abnormal_pinna_reflex0.90694016
84MP0000778_abnormal_nervous_system0.88861802
85MP0001542_abnormal_bone_strength0.88590870
86MP0001270_distended_abdomen0.86180989
87MP0001145_abnormal_male_reproductive0.85124705
88MP0005646_abnormal_pituitary_gland0.84106240
89MP0005394_taste/olfaction_phenotype0.83956167
90MP0005499_abnormal_olfactory_system0.83956167
91MP0002066_abnormal_motor_capabilities/c0.83429779
92MP0003633_abnormal_nervous_system0.82666943
93MP0004510_myositis0.82413212
94MP0002069_abnormal_eating/drinking_beha0.81327091
95MP0001905_abnormal_dopamine_level0.80588346
96MP0004924_abnormal_behavior0.80542328
97MP0005386_behavior/neurological_phenoty0.80542328
98MP0003632_abnormal_nervous_system0.80145518
99MP0002234_abnormal_pharynx_morphology0.79337370
100MP0000751_myopathy0.78803775
101MP0003122_maternal_imprinting0.78562902
102MP0000604_amyloidosis0.78122005
103MP0000747_muscle_weakness0.77078228
104MP0002876_abnormal_thyroid_physiology0.76727096
105MP0000538_abnormal_urinary_bladder0.75882786
106MP0003631_nervous_system_phenotype0.75381225
107MP0008874_decreased_physiological_sensi0.74815182
108MP0004147_increased_porphyrin_level0.74186823
109MP0000566_synostosis0.72830563
110MP0002152_abnormal_brain_morphology0.72072099
111MP0001188_hyperpigmentation0.71477694
112MP0000653_abnormal_sex_gland0.71087830
113MP0001346_abnormal_lacrimal_gland0.70326972
114MP0003385_abnormal_body_wall0.69560361
115MP0004130_abnormal_muscle_cell0.69321749
116MP0002168_other_aberrant_phenotype0.66832779
117MP0002752_abnormal_somatic_nervous0.64094383
118MP0004272_abnormal_basement_membrane0.63112693
119MP0000013_abnormal_adipose_tissue0.63091440
120MP0001664_abnormal_digestion0.62966059
121MP0004043_abnormal_pH_regulation0.62882923
122MP0001986_abnormal_taste_sensitivity0.62830239
123MP0005423_abnormal_somatic_nervous0.62817153
124MP0002269_muscular_atrophy0.62726793
125MP0001529_abnormal_vocalization0.61814415
126MP0003634_abnormal_glial_cell0.61018010
127MP0002282_abnormal_trachea_morphology0.60987844
128MP0003091_abnormal_cell_migration0.60422516
129MP0004742_abnormal_vestibular_system0.59546125
130MP0002108_abnormal_muscle_morphology0.58688833
131MP0009250_abnormal_appendicular_skeleto0.58034677
132MP0001943_abnormal_respiration0.57729342
133MP0005360_urolithiasis0.57382168
134MP0000733_abnormal_muscle_development0.56199107
135MP0002896_abnormal_bone_mineralization0.55826693

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.96366524
2Absent/shortened dynein arms (HP:0200106)6.96366524
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.56637993
4Abnormal respiratory motile cilium physiology (HP:0012261)4.92053725
5Abnormal respiratory motile cilium morphology (HP:0005938)4.80634019
6Abnormal respiratory epithelium morphology (HP:0012253)4.80634019
7Rhinitis (HP:0012384)4.49034631
8Abnormal ciliary motility (HP:0012262)3.90357633
9Infertility (HP:0000789)3.84518964
10Chronic bronchitis (HP:0004469)3.80253339
11Myokymia (HP:0002411)3.57122897
12Focal motor seizures (HP:0011153)3.51450127
13Supranuclear gaze palsy (HP:0000605)3.12266306
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01871998
15Abnormality of alanine metabolism (HP:0010916)3.01871998
16Hyperalaninemia (HP:0003348)3.01871998
17Congenital sensorineural hearing impairment (HP:0008527)3.00818987
18Hypercortisolism (HP:0001578)2.99552196
19Spastic gait (HP:0002064)2.97661620
20Intention tremor (HP:0002080)2.85112187
21Diplopia (HP:0000651)2.84390582
22Abnormality of binocular vision (HP:0011514)2.84390582
23Protrusio acetabuli (HP:0003179)2.83138815
24White forelock (HP:0002211)2.81607191
25Aplasia involving bones of the upper limbs (HP:0009823)2.77432775
26Aplasia of the phalanges of the hand (HP:0009802)2.77432775
27Aplasia involving bones of the extremities (HP:0009825)2.77432775
28Abnormality of dentin (HP:0010299)2.76673372
29Progressive cerebellar ataxia (HP:0002073)2.74045513
30Hypoventilation (HP:0002791)2.73748350
31Focal seizures (HP:0007359)2.71781490
32Visual hallucinations (HP:0002367)2.65246828
33Heterochromia iridis (HP:0001100)2.64157982
34Premature rupture of membranes (HP:0001788)2.58977272
35Dysmetria (HP:0001310)2.56711018
36Action tremor (HP:0002345)2.53068933
37Fetal akinesia sequence (HP:0001989)2.49763345
38Hypoalphalipoproteinemia (HP:0003233)2.49043893
39Nasal polyposis (HP:0100582)2.47196586
40Male infertility (HP:0003251)2.45169308
41Clonus (HP:0002169)2.41984441
42Chronic hepatic failure (HP:0100626)2.37325575
43Atrophic scars (HP:0001075)2.36388555
44Depression (HP:0000716)2.33534267
45Urinary bladder sphincter dysfunction (HP:0002839)2.32563499
46Abnormality of the corticospinal tract (HP:0002492)2.31770122
47Papilledema (HP:0001085)2.29597298
48Amblyopia (HP:0000646)2.26505847
49Patchy hypopigmentation of hair (HP:0011365)2.25494454
50Esophageal varix (HP:0002040)2.23991004
51Hypoplastic heart (HP:0001961)2.23878346
52Febrile seizures (HP:0002373)2.23512031
53Choroideremia (HP:0001139)2.21688784
54Neurofibrillary tangles (HP:0002185)2.21606853
55Hyperthyroidism (HP:0000836)2.18708786
56Delusions (HP:0000746)2.17058492
57Hypoplastic left heart (HP:0004383)2.15810828
58Ulnar claw (HP:0001178)2.15610222
59Akinesia (HP:0002304)2.15564568
60Torticollis (HP:0000473)2.14404077
61Cerebral hypomyelination (HP:0006808)2.14285880
62Hand muscle atrophy (HP:0009130)2.13969820
63Spinal canal stenosis (HP:0003416)2.13381313
64Insulin-resistant diabetes mellitus (HP:0000831)2.12622137
65Thin ribs (HP:0000883)2.12313295
66Enlarged penis (HP:0000040)2.11987332
67Nephronophthisis (HP:0000090)2.11301934
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.11252013
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11252013
70Cerebral inclusion bodies (HP:0100314)2.09030992
71Obstructive sleep apnea (HP:0002870)2.08189067
72Insomnia (HP:0100785)2.08151143
73Upper limb amyotrophy (HP:0009129)2.07209862
74Distal upper limb amyotrophy (HP:0007149)2.07209862
75Absence seizures (HP:0002121)2.04351575
76Peripheral hypomyelination (HP:0007182)2.03434301
77Bowel diverticulosis (HP:0005222)2.02309954
78Annular pancreas (HP:0001734)2.00061675
79Fragile skin (HP:0001030)1.99882151
80Abnormality of the aortic arch (HP:0012303)1.99026878
81Hypothermia (HP:0002045)1.97681715
82Abnormal eating behavior (HP:0100738)1.97664210
83Broad metatarsal (HP:0001783)1.97171413
84Attenuation of retinal blood vessels (HP:0007843)1.97047358
85Short nail (HP:0001799)1.96455255
86Atonic seizures (HP:0010819)1.95910653
87Truncal ataxia (HP:0002078)1.95376251
88Buphthalmos (HP:0000557)1.94709714
89Bell-shaped thorax (HP:0001591)1.94331061
90Limb dystonia (HP:0002451)1.93687337
91Tetraparesis (HP:0002273)1.92429141
92Constricted visual fields (HP:0001133)1.87259711
93Tubular atrophy (HP:0000092)1.85881376
94Zonular cataract (HP:0010920)1.85720602
95Narrow nasal bridge (HP:0000446)1.84648797
96Bladder diverticulum (HP:0000015)1.84421639
97Epileptic encephalopathy (HP:0200134)1.82954290
98Abnormality of the nasal mucosa (HP:0000433)1.82339769
99Bradykinesia (HP:0002067)1.81584256
100Poor speech (HP:0002465)1.81290771
101Stereotypic behavior (HP:0000733)1.80641425
102Shallow orbits (HP:0000586)1.79525449
103Tubulointerstitial fibrosis (HP:0005576)1.76011250
104Hemiparesis (HP:0001269)1.75937955
105Impaired vibratory sensation (HP:0002495)1.75562579
106Neuronal loss in central nervous system (HP:0002529)1.74739159
107Bowel incontinence (HP:0002607)1.74404570
108Bradycardia (HP:0001662)1.74270089
109Postural instability (HP:0002172)1.74114358
110Biconcave vertebral bodies (HP:0004586)1.73763059
111Severe visual impairment (HP:0001141)1.73193757
112Urinary urgency (HP:0000012)1.72703485
113Bronchitis (HP:0012387)1.72399946
114Bronchiectasis (HP:0002110)1.72121221
115Absent speech (HP:0001344)1.71347007
116Ankle clonus (HP:0011448)1.71195319
117Hyperparathyroidism (HP:0000843)1.70262373
118Abnormality of the lower motor neuron (HP:0002366)1.69580104
119Myopathic facies (HP:0002058)1.69085215
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69065723
121Generalized tonic-clonic seizures (HP:0002069)1.67907339
122Tetraplegia (HP:0002445)1.67650734
123Median cleft lip (HP:0000161)1.67449021
124Long toe (HP:0010511)1.66232562
125Nuclear cataract (HP:0100018)1.65374969
126Abnormality of the renal medulla (HP:0100957)1.65326466
127Asymmetric septal hypertrophy (HP:0001670)1.65175738
128Complete atrioventricular canal defect (HP:0001674)1.64782735
129Impaired vibration sensation in the lower limbs (HP:0002166)1.64575891
130Genu recurvatum (HP:0002816)1.64342517
131Occipital encephalocele (HP:0002085)1.62974972
132Menstrual irregularities (HP:0000858)1.62749558
133Dialeptic seizures (HP:0011146)1.62188816
134Abnormal gallbladder physiology (HP:0012438)1.60691949
135Cholecystitis (HP:0001082)1.60691949
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.59386737
137Congenital glaucoma (HP:0001087)1.59277967
138Difficulty climbing stairs (HP:0003551)1.58938825
139Potter facies (HP:0002009)1.58528611
140Facial shape deformation (HP:0011334)1.58528611
141Abnormality of molar (HP:0011077)1.58021275
142Abnormality of molar morphology (HP:0011070)1.58021275
143Urinary incontinence (HP:0000020)1.57474465
144Neonatal short-limb short stature (HP:0008921)1.56529105
145Tubulointerstitial abnormality (HP:0001969)1.56126046
146Growth hormone excess (HP:0000845)1.55381199
147Neoplasm of the heart (HP:0100544)1.54821862
148Abnormality of permanent molar morphology (HP:0011071)1.53815245
149Abnormality of the dental root (HP:0006486)1.53815245
150Taurodontia (HP:0000679)1.53815245
151Cerebral aneurysm (HP:0004944)1.52072620
152Adrenal overactivity (HP:0002717)1.50688298
153Abnormality of calcium-phosphate metabolism (HP:0100530)1.50377406
154Medial flaring of the eyebrow (HP:0010747)1.49776189
155Lower limb muscle weakness (HP:0007340)1.49697064
156Aplasia/Hypoplasia of the lens (HP:0008063)1.49552001
157Broad distal phalanx of finger (HP:0009836)1.49549596
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.49368112
159Rapidly progressive (HP:0003678)1.48459084
160Tubulointerstitial nephritis (HP:0001970)1.47905931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.93238343
2TESK14.58555127
3PDK33.76020502
4PDK43.76020502
5ICK2.99072266
6NTRK32.94744257
7NTRK12.78151103
8PDK22.54502455
9MAP3K92.41798501
10UHMK12.32969737
11STK382.13938675
12MAP3K42.01810372
13PTK2B2.00540977
14MINK11.96756647
15LATS21.82696735
16MAP2K71.78577766
17CAMKK11.71346129
18EPHA41.68347736
19DDR21.67204705
20LMTK21.63363647
21MAP3K111.59211603
22NTRK21.52948756
23RIPK41.49615708
24GRK51.46218072
25PAK61.44722112
26KSR21.39917571
27TIE11.39119788
28MAPK151.37824577
29PRKCG1.33315513
30TRIB31.33018645
31DAPK21.31724977
32MAP3K31.26496328
33MAP3K21.25040643
34MOS1.24220351
35INSRR1.19828146
36DYRK1B1.19493250
37WNK41.17881563
38RET1.12179092
39PNCK1.11925658
40PDGFRA1.10774711
41MAP2K41.07458891
42PINK11.05077102
43ARAF1.04755010
44FER1.03155362
45CDK191.00475112
46CDK90.95231095
47PLK20.94496425
48TYRO30.89714371
49CAMK2B0.89428539
50WNK10.89249683
51MATK0.87339072
52PDK10.87245142
53FGR0.86685382
54PDPK10.84149955
55CAMK2G0.82120021
56PKN10.80832122
57STK38L0.79713895
58MAP3K120.79661252
59MUSK0.79351063
60MAP3K130.79268713
61CAMKK20.77262552
62MAPKAPK50.77122956
63CDK50.76831788
64MARK10.75827863
65PLK40.75821993
66EPHB20.74939717
67PTK20.74914456
68MAP2K30.72574590
69MAP2K10.71792643
70ROCK20.71398951
71CDK140.69365516
72ROCK10.69336422
73CDK180.67373329
74CDK150.67271470
75CCNB10.66893732
76BRAF0.66272133
77RIPK10.66135016
78MET0.64754446
79NEK60.64314126
80MAPK130.64162190
81SGK10.63769015
82CAMK1G0.62609878
83DYRK1A0.60538537
84BMX0.59665594
85CAMK2D0.59177540
86CDC42BPA0.59142699
87EPHA30.57973043
88PRKCE0.57180244
89AKT30.55889024
90PRPF4B0.55664733
91CDK11A0.53733355
92CAMK2A0.53192313
93DAPK10.53025967
94BRSK10.53013721
95CASK0.52993752
96DAPK30.52676298
97CAMK10.52505623
98STK390.52210936
99CSNK1G20.51828102
100CAMK40.51218873
101PRKCZ0.50989778
102MAPK100.50455274
103KSR10.49157361
104MAP2K60.48667942
105TNK20.47028355
106RPS6KA20.46677755
107PAK30.46345685
108PHKG10.43859169
109PHKG20.43859169
110PRKG10.43458972
111FGFR20.42659401
112EPHA20.42600802
113ADRBK10.41940687
114MAP3K70.41685570
115PDGFRB0.41473809
116SGK2230.40950742
117SGK4940.40950742
118MARK20.40323253
119TRIM280.39482657
120LIMK10.39099493
121PRKCH0.38013643
122IRAK10.37564366
123CSNK1A10.36660915
124JAK30.36615959
125STK110.36315301
126PAK20.36140497
127MAP3K10.33590080
128PRKD20.31979128
129SGK30.31853302
130SIK20.31532148
131SGK20.28312356
132PKN20.28090347
133PRKG20.26034416
134SRC0.25504078

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.20419748
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.58753507
3Amphetamine addiction_Homo sapiens_hsa050312.35277254
4Olfactory transduction_Homo sapiens_hsa047402.19208688
5Nicotine addiction_Homo sapiens_hsa050332.12022572
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.04180218
7Circadian entrainment_Homo sapiens_hsa047131.96999845
8Salivary secretion_Homo sapiens_hsa049701.84444666
9Long-term potentiation_Homo sapiens_hsa047201.84012587
10Insulin secretion_Homo sapiens_hsa049111.83845681
11Fatty acid biosynthesis_Homo sapiens_hsa000611.82562966
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.78515646
13Collecting duct acid secretion_Homo sapiens_hsa049661.73256995
14Dopaminergic synapse_Homo sapiens_hsa047281.72756845
15Cocaine addiction_Homo sapiens_hsa050301.69481079
16Renin secretion_Homo sapiens_hsa049241.62904996
17Glutamatergic synapse_Homo sapiens_hsa047241.60145621
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58932322
19Taste transduction_Homo sapiens_hsa047421.57779462
20Cholinergic synapse_Homo sapiens_hsa047251.50213948
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49793988
22Morphine addiction_Homo sapiens_hsa050321.47807606
23Gastric acid secretion_Homo sapiens_hsa049711.45953494
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39888275
25Arginine biosynthesis_Homo sapiens_hsa002201.38731195
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38577676
27GABAergic synapse_Homo sapiens_hsa047271.36339251
28Estrogen signaling pathway_Homo sapiens_hsa049151.35042691
29Calcium signaling pathway_Homo sapiens_hsa040201.33312897
30Serotonergic synapse_Homo sapiens_hsa047261.26674162
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23426589
32Glucagon signaling pathway_Homo sapiens_hsa049221.22421692
33Oxytocin signaling pathway_Homo sapiens_hsa049211.20695844
34GnRH signaling pathway_Homo sapiens_hsa049121.18726628
35Gap junction_Homo sapiens_hsa045401.18228452
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17418759
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15827532
38Hedgehog signaling pathway_Homo sapiens_hsa043401.15747758
39Vibrio cholerae infection_Homo sapiens_hsa051101.15544817
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14549051
41Dorso-ventral axis formation_Homo sapiens_hsa043201.14005992
42Long-term depression_Homo sapiens_hsa047301.11213015
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09634270
44Melanogenesis_Homo sapiens_hsa049161.08715626
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08068176
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.03811134
47cAMP signaling pathway_Homo sapiens_hsa040241.03780413
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02383490
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98286988
50Glioma_Homo sapiens_hsa052140.97006161
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96133348
52Thyroid hormone synthesis_Homo sapiens_hsa049180.96037625
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95944995
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.92678856
55Prion diseases_Homo sapiens_hsa050200.92274266
56Sulfur relay system_Homo sapiens_hsa041220.92163831
57Cardiac muscle contraction_Homo sapiens_hsa042600.92152564
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89868104
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.89847315
60Mineral absorption_Homo sapiens_hsa049780.89324547
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88716654
62ECM-receptor interaction_Homo sapiens_hsa045120.86433017
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86016197
64Oocyte meiosis_Homo sapiens_hsa041140.83218925
65Regulation of autophagy_Homo sapiens_hsa041400.82461997
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80333731
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78178340
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77789044
69Type II diabetes mellitus_Homo sapiens_hsa049300.77196643
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.77146647
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76246925
72Circadian rhythm_Homo sapiens_hsa047100.75885593
73Vitamin B6 metabolism_Homo sapiens_hsa007500.75395207
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74440069
75Axon guidance_Homo sapiens_hsa043600.74053866
76Phagosome_Homo sapiens_hsa041450.74031824
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73996164
78ErbB signaling pathway_Homo sapiens_hsa040120.71672057
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71263278
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.70641662
81Protein digestion and absorption_Homo sapiens_hsa049740.69379987
82Endocytosis_Homo sapiens_hsa041440.69118417
83Glycerolipid metabolism_Homo sapiens_hsa005610.67213879
84Dilated cardiomyopathy_Homo sapiens_hsa054140.64883195
85VEGF signaling pathway_Homo sapiens_hsa043700.64867767
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64863322
87Inositol phosphate metabolism_Homo sapiens_hsa005620.62589760
88Wnt signaling pathway_Homo sapiens_hsa043100.62541988
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62530670
90Rheumatoid arthritis_Homo sapiens_hsa053230.61038198
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59179648
92MAPK signaling pathway_Homo sapiens_hsa040100.59171237
93Rap1 signaling pathway_Homo sapiens_hsa040150.58816510
94Choline metabolism in cancer_Homo sapiens_hsa052310.58110278
95Alcoholism_Homo sapiens_hsa050340.57868832
96Amoebiasis_Homo sapiens_hsa051460.57794397
97Basal cell carcinoma_Homo sapiens_hsa052170.57382917
98Hippo signaling pathway_Homo sapiens_hsa043900.56906883
99Focal adhesion_Homo sapiens_hsa045100.55750448
100Pancreatic secretion_Homo sapiens_hsa049720.55239411
101Insulin signaling pathway_Homo sapiens_hsa049100.52477944
102ABC transporters_Homo sapiens_hsa020100.52094101
103Histidine metabolism_Homo sapiens_hsa003400.51232046
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.50097504
105Folate biosynthesis_Homo sapiens_hsa007900.50076557
106Salmonella infection_Homo sapiens_hsa051320.48322150
107Melanoma_Homo sapiens_hsa052180.47454184
108mTOR signaling pathway_Homo sapiens_hsa041500.47409731
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.47392857
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47340035
111Biosynthesis of amino acids_Homo sapiens_hsa012300.46593687
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46185007
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46159861
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45955220
115Ras signaling pathway_Homo sapiens_hsa040140.45712920
116Bladder cancer_Homo sapiens_hsa052190.45641399
117Endometrial cancer_Homo sapiens_hsa052130.44831257
118Bile secretion_Homo sapiens_hsa049760.44561671
119Other glycan degradation_Homo sapiens_hsa005110.42730008
120AMPK signaling pathway_Homo sapiens_hsa041520.42238482
121Tight junction_Homo sapiens_hsa045300.39900739
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39127773
123Galactose metabolism_Homo sapiens_hsa000520.36984849
124Phototransduction_Homo sapiens_hsa047440.35256687

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