B3GALNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.32820881
2neuron cell-cell adhesion (GO:0007158)5.19616843
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99443651
4vocalization behavior (GO:0071625)4.91144390
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.86125851
6regulation of synaptic vesicle exocytosis (GO:2000300)4.76214285
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76187256
8glutamate secretion (GO:0014047)4.63631413
9pyrimidine nucleobase catabolic process (GO:0006208)4.59599296
10presynaptic membrane assembly (GO:0097105)4.54524696
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.44876475
12protein localization to synapse (GO:0035418)4.38905081
13negative regulation of synaptic transmission, GABAergic (GO:0032229)4.35901371
14neuronal action potential propagation (GO:0019227)4.30662798
15regulation of glutamate receptor signaling pathway (GO:1900449)4.27640389
16neurotransmitter-gated ion channel clustering (GO:0072578)4.20943496
17regulation of synaptic vesicle transport (GO:1902803)4.20902363
18postsynaptic membrane organization (GO:0001941)4.14116034
19presynaptic membrane organization (GO:0097090)4.13732347
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.08175110
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01689498
22gamma-aminobutyric acid signaling pathway (GO:0007214)3.93290671
23ATP hydrolysis coupled proton transport (GO:0015991)3.92921392
24energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.92921392
25neurotransmitter secretion (GO:0007269)3.91825435
26synaptic vesicle maturation (GO:0016188)3.91513380
27transferrin transport (GO:0033572)3.88100560
28neuron-neuron synaptic transmission (GO:0007270)3.73884796
29auditory behavior (GO:0031223)3.73021830
30neuron recognition (GO:0008038)3.70807197
31nucleobase catabolic process (GO:0046113)3.69286154
32ferric iron transport (GO:0015682)3.65603156
33trivalent inorganic cation transport (GO:0072512)3.65603156
34synaptic transmission, glutamatergic (GO:0035249)3.62513619
35locomotory exploration behavior (GO:0035641)3.58091570
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.56644453
37response to histamine (GO:0034776)3.56163374
38negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.55832844
39proline transport (GO:0015824)3.50764815
40long-term synaptic potentiation (GO:0060291)3.49636287
41glutamate receptor signaling pathway (GO:0007215)3.45405966
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44799858
43positive regulation of synapse assembly (GO:0051965)3.41801295
44exploration behavior (GO:0035640)3.34040372
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32764884
46axonal fasciculation (GO:0007413)3.31631824
47cell migration in hindbrain (GO:0021535)3.31572204
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.30719939
49neurotransmitter transport (GO:0006836)3.29523067
50regulation of glutamate secretion (GO:0014048)3.28069905
51regulation of long-term neuronal synaptic plasticity (GO:0048169)3.26573327
52regulation of postsynaptic membrane potential (GO:0060078)3.26265773
53detection of calcium ion (GO:0005513)3.24257448
54positive regulation of synapse maturation (GO:0090129)3.24136935
55response to auditory stimulus (GO:0010996)3.22404707
56regulation of vesicle fusion (GO:0031338)3.21860686
57synaptic vesicle endocytosis (GO:0048488)3.20874869
58central nervous system projection neuron axonogenesis (GO:0021952)3.18001984
59innervation (GO:0060384)3.16333107
60startle response (GO:0001964)3.16112693
61regulation of neuronal synaptic plasticity (GO:0048168)3.13941235
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.13885425
63cerebellar granule cell differentiation (GO:0021707)3.11442592
64fear response (GO:0042596)3.10116357
65regulation of neurotransmitter secretion (GO:0046928)3.09381456
66female mating behavior (GO:0060180)3.08628619
67transmission of nerve impulse (GO:0019226)3.06936666
68regulation of synapse assembly (GO:0051963)3.02247052
69behavioral fear response (GO:0001662)3.00809768
70behavioral defense response (GO:0002209)3.00809768
71positive regulation of membrane potential (GO:0045838)2.98154131
72establishment of synaptic vesicle localization (GO:0097480)2.97116214
73synaptic vesicle transport (GO:0048489)2.97116214
74regulation of neurotransmitter levels (GO:0001505)2.92103300
75protein localization to cilium (GO:0061512)2.91945929
76positive regulation of action potential (GO:0045760)2.91265040
77regulation of synapse structural plasticity (GO:0051823)2.90803391
78negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90578403
79positive regulation of neurotransmitter transport (GO:0051590)2.90229492
80dendrite morphogenesis (GO:0048813)2.90196611
81regulation of synaptic plasticity (GO:0048167)2.89835195
82serotonin metabolic process (GO:0042428)2.89812310
83negative regulation of dendrite morphogenesis (GO:0050774)2.89264990
84positive regulation of neurotransmitter secretion (GO:0001956)2.88929599
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88039815
86calcium ion-dependent exocytosis (GO:0017156)2.87431225
87mechanosensory behavior (GO:0007638)2.86133355
88synapse assembly (GO:0007416)2.85710941
89regulation of neurotransmitter transport (GO:0051588)2.84767203
90negative regulation of amine transport (GO:0051953)2.82163713
91layer formation in cerebral cortex (GO:0021819)2.81796796
92behavioral response to cocaine (GO:0048148)2.81070386
93phagosome maturation (GO:0090382)2.80972985
94membrane depolarization (GO:0051899)2.80908706
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.80830043
96activation of protein kinase A activity (GO:0034199)2.79356747
97gamma-aminobutyric acid transport (GO:0015812)2.79301805
98cerebellar Purkinje cell differentiation (GO:0021702)2.78908941
99positive regulation of synaptic transmission (GO:0050806)2.78383333
100synaptic transmission (GO:0007268)2.77822106
101regulation of synaptic transmission, GABAergic (GO:0032228)2.77015837
102regulation of female receptivity (GO:0045924)2.73451891
103regulation of feeding behavior (GO:0060259)2.73349572
104regulation of synapse maturation (GO:0090128)2.73343287
105regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72917388
106establishment of vesicle localization (GO:0051650)2.72791413
107behavioral response to ethanol (GO:0048149)2.72595264
108opioid receptor signaling pathway (GO:0038003)2.72213874
109neuromuscular process controlling posture (GO:0050884)2.71255414
110G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70628391
111positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69717387
112serotonin receptor signaling pathway (GO:0007210)2.68803801
113positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.67060710
114regulation of synaptic transmission (GO:0050804)2.66594889
115neuronal action potential (GO:0019228)2.66140955
116nonmotile primary cilium assembly (GO:0035058)2.65434438
117regulation of cell communication by electrical coupling (GO:0010649)2.64440514
118regulation of cAMP-dependent protein kinase activity (GO:2000479)2.64262358
119central nervous system neuron axonogenesis (GO:0021955)2.63436850
120retinal ganglion cell axon guidance (GO:0031290)2.62881007
121axon extension (GO:0048675)2.62690929
122neurofilament cytoskeleton organization (GO:0060052)2.61533611
123cerebral cortex radially oriented cell migration (GO:0021799)2.60290439
124limb bud formation (GO:0060174)2.58495510
125response to pheromone (GO:0019236)2.57100583
126neuronal ion channel clustering (GO:0045161)2.54745262
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.51070543
128neuromuscular synaptic transmission (GO:0007274)2.50109576
129apical protein localization (GO:0045176)2.49004338
130negative regulation of dendrite development (GO:2000171)2.47742308
131regulation of axon guidance (GO:1902667)2.47492710
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46200834
133membrane depolarization during action potential (GO:0086010)2.45195487
134positive regulation of meiosis (GO:0045836)2.43034137
135synapse organization (GO:0050808)2.42637302
136regulation of action potential (GO:0098900)2.41072861
137negative regulation of axon extension (GO:0030517)2.40946302
138regulation of meiosis I (GO:0060631)2.40538190
139spinal cord development (GO:0021510)2.40256994
140positive regulation of mitochondrial fission (GO:0090141)2.38064932
141cell communication by electrical coupling (GO:0010644)2.36182457
142regulation of dendritic spine morphogenesis (GO:0061001)2.35511381
143urinary tract smooth muscle contraction (GO:0014848)2.35081006
144dendritic spine morphogenesis (GO:0060997)2.34563511
145axonogenesis (GO:0007409)2.34561364
146righting reflex (GO:0060013)2.34012263
147regulation of axon extension involved in axon guidance (GO:0048841)2.33698804
148C4-dicarboxylate transport (GO:0015740)2.33278446
149glycosphingolipid biosynthetic process (GO:0006688)2.32238553
150retina layer formation (GO:0010842)2.32041853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60128487
2GBX2_23144817_ChIP-Seq_PC3_Human4.47543351
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00014580
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87543812
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69793655
6TAF15_26573619_Chip-Seq_HEK293_Human2.61675741
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.58622900
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56816202
9REST_21632747_ChIP-Seq_MESCs_Mouse2.44099696
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.43543757
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43058399
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42689501
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40957484
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.38740092
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33189189
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33189189
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31168801
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.26400052
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24256873
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21887521
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19314773
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16453051
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14577980
24CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11780856
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07983387
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.03581170
27* P300_19829295_ChIP-Seq_ESCs_Human2.00171327
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97069610
29SMAD4_21799915_ChIP-Seq_A2780_Human1.95362637
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94237532
31VDR_22108803_ChIP-Seq_LS180_Human1.92299656
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.90608239
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.89432126
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87315730
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.85993258
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72241854
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.69565726
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69360215
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.63463666
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61967128
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.61325112
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.60792090
43IGF1R_20145208_ChIP-Seq_DFB_Human1.58907868
44* FUS_26573619_Chip-Seq_HEK293_Human1.56751607
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55221209
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54824137
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54368836
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54028390
49RNF2_27304074_Chip-Seq_NSC_Mouse1.52637011
50ZNF274_21170338_ChIP-Seq_K562_Hela1.49125777
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46383296
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45920981
53DROSHA_22980978_ChIP-Seq_HELA_Human1.45152933
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.45079583
55AR_25329375_ChIP-Seq_VCAP_Human1.44237238
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43688453
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43276951
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39537640
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.36674320
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.34264692
61ER_23166858_ChIP-Seq_MCF-7_Human1.33011522
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32019968
63AR_21572438_ChIP-Seq_LNCaP_Human1.31148369
64KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.29026798
65* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28211411
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.27804425
67* STAT3_23295773_ChIP-Seq_U87_Human1.26789318
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26591761
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25296379
70JUN_21703547_ChIP-Seq_K562_Human1.22869645
71* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21388730
72TCF4_23295773_ChIP-Seq_U87_Human1.21027568
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20420917
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.19132344
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17087616
76RUNX2_22187159_ChIP-Seq_PCA_Human1.17079869
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17005571
78CBP_20019798_ChIP-Seq_JUKART_Human1.17005571
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16958150
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15669985
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15454738
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15454738
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.15144991
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14188308
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11491374
86* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11017648
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10891354
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09907390
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09634098
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.06502233
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06480609
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.05814400
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05231558
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05040871
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04828664
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04718280
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.04131459
98TP53_18474530_ChIP-ChIP_U2OS_Human1.04094672
99AHR_22903824_ChIP-Seq_MCF-7_Human1.03976768
100EWS_26573619_Chip-Seq_HEK293_Human1.03868282
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03430012
102* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03331545
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03278340
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03111428
105BCAT_22108803_ChIP-Seq_LS180_Human1.02384574
106AR_19668381_ChIP-Seq_PC3_Human1.00828223
107RING1B_27294783_Chip-Seq_ESCs_Mouse0.99821761
108* KDM2B_26808549_Chip-Seq_REH_Human0.99507948
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99416620
110FLI1_21867929_ChIP-Seq_TH2_Mouse0.98888229
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97781436
112REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94935293
113* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94644735
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94541845
115SOX9_26525672_Chip-Seq_HEART_Mouse0.94415023
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94097380
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93638292
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.91614502
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91030749

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.79479612
2MP0004859_abnormal_synaptic_plasticity4.27317740
3MP0003635_abnormal_synaptic_transmissio3.52649049
4MP0009745_abnormal_behavioral_response3.03638626
5MP0004270_analgesia3.03559078
6MP0002063_abnormal_learning/memory/cond2.97640130
7MP0001968_abnormal_touch/_nociception2.94719831
8MP0002064_seizures2.90441561
9MP0009046_muscle_twitch2.76107032
10MP0003122_maternal_imprinting2.75736111
11MP0002572_abnormal_emotion/affect_behav2.71613057
12MP0009780_abnormal_chondrocyte_physiolo2.66591335
13MP0006276_abnormal_autonomic_nervous2.66254527
14MP0002736_abnormal_nociception_after2.56979758
15MP0002734_abnormal_mechanical_nocicepti2.49482072
16MP0002272_abnormal_nervous_system2.35688849
17MP0002735_abnormal_chemical_nociception2.33917270
18MP0010386_abnormal_urinary_bladder2.32995966
19MP0005646_abnormal_pituitary_gland2.31186121
20MP0001501_abnormal_sleep_pattern2.29470103
21MP0002837_dystrophic_cardiac_calcinosis2.27498766
22MP0001440_abnormal_grooming_behavior2.27146236
23MP0002067_abnormal_sensory_capabilities2.01908183
24MP0002733_abnormal_thermal_nociception1.96094489
25MP0002822_catalepsy1.93258530
26MP0001188_hyperpigmentation1.92457690
27MP0002184_abnormal_innervation1.91945302
28MP0000013_abnormal_adipose_tissue1.90632668
29MP0002876_abnormal_thyroid_physiology1.90599163
30MP0001529_abnormal_vocalization1.90371201
31MP0002909_abnormal_adrenal_gland1.89549821
32MP0005645_abnormal_hypothalamus_physiol1.89144358
33MP0001970_abnormal_pain_threshold1.85959502
34MP0001486_abnormal_startle_reflex1.82817565
35MP0003787_abnormal_imprinting1.78209587
36MP0003879_abnormal_hair_cell1.77780559
37MP0005423_abnormal_somatic_nervous1.76475582
38MP0008789_abnormal_olfactory_epithelium1.74309640
39MP0005499_abnormal_olfactory_system1.71773210
40MP0005394_taste/olfaction_phenotype1.71773210
41MP0000778_abnormal_nervous_system1.69018364
42MP0006292_abnormal_olfactory_placode1.68281534
43MP0002557_abnormal_social/conspecific_i1.65451569
44MP0005386_behavior/neurological_phenoty1.64884486
45MP0004924_abnormal_behavior1.64884486
46MP0001984_abnormal_olfaction1.53994499
47MP0000566_synostosis1.51246280
48MP0001905_abnormal_dopamine_level1.47302753
49MP0004142_abnormal_muscle_tone1.40892473
50MP0004811_abnormal_neuron_physiology1.40283063
51MP0003183_abnormal_peptide_metabolism1.36870265
52MP0002234_abnormal_pharynx_morphology1.35616633
53MP0000955_abnormal_spinal_cord1.34566049
54MP0005248_abnormal_Harderian_gland1.33114434
55MP0002638_abnormal_pupillary_reflex1.31585422
56MP0003890_abnormal_embryonic-extraembry1.26603598
57MP0002066_abnormal_motor_capabilities/c1.25072612
58MP0004133_heterotaxia1.23214739
59MP0002882_abnormal_neuron_morphology1.22574580
60MP0002233_abnormal_nose_morphology1.17973469
61MP0001502_abnormal_circadian_rhythm1.17921288
62MP0002102_abnormal_ear_morphology1.16470051
63MP0000751_myopathy1.15243979
64MP0008569_lethality_at_weaning1.15097222
65MP0000631_abnormal_neuroendocrine_gland1.14185479
66MP0003121_genomic_imprinting1.12856370
67MP0004043_abnormal_pH_regulation1.12526862
68MP0005187_abnormal_penis_morphology1.11922040
69MP0003329_amyloid_beta_deposits1.08441858
70MP0003119_abnormal_digestive_system1.08151870
71MP0004858_abnormal_nervous_system1.04520024
72MP0000537_abnormal_urethra_morphology1.02877874
73MP0004084_abnormal_cardiac_muscle1.02366515
74MP0001485_abnormal_pinna_reflex1.01905915
75MP0005379_endocrine/exocrine_gland_phen0.99150637
76MP0005171_absent_coat_pigmentation0.97440818
77MP0003123_paternal_imprinting0.96505898
78MP0003861_abnormal_nervous_system0.95390156
79MP0003633_abnormal_nervous_system0.94537072
80MP0002751_abnormal_autonomic_nervous0.93334426
81MP0002152_abnormal_brain_morphology0.92827330
82MP0000569_abnormal_digit_pigmentation0.92756452
83MP0005535_abnormal_body_temperature0.91586241
84MP0002069_abnormal_eating/drinking_beha0.91380810
85MP0003937_abnormal_limbs/digits/tail_de0.91240794
86MP0005253_abnormal_eye_physiology0.91219229
87MP0003137_abnormal_impulse_conducting0.89318089
88MP0006072_abnormal_retinal_apoptosis0.88759817
89MP0000534_abnormal_ureter_morphology0.88691567
90MP0002653_abnormal_ependyma_morphology0.86618517
91MP0004085_abnormal_heartbeat0.85869335
92MP0005551_abnormal_eye_electrophysiolog0.82764182
93MP0003283_abnormal_digestive_organ0.82649101
94MP0004233_abnormal_muscle_weight0.82489909
95MP0001664_abnormal_digestion0.82366705
96MP0001963_abnormal_hearing_physiology0.81848166
97MP0003385_abnormal_body_wall0.81490015
98MP0000462_abnormal_digestive_system0.80070070
99MP0003942_abnormal_urinary_system0.79374940
100MP0000681_abnormal_thyroid_gland0.79309845
101MP0005195_abnormal_posterior_eye0.78040930
102MP0000049_abnormal_middle_ear0.78010268
103MP0002229_neurodegeneration0.76922025
104MP0003631_nervous_system_phenotype0.76405258
105MP0000538_abnormal_urinary_bladder0.75610362
106MP0004742_abnormal_vestibular_system0.75523665
107MP0003755_abnormal_palate_morphology0.73603577
108MP0000383_abnormal_hair_follicle0.71899829
109MP0004145_abnormal_muscle_electrophysio0.71040551
110MP0009250_abnormal_appendicular_skeleto0.70114777
111MP0002752_abnormal_somatic_nervous0.68181744
112MP0002163_abnormal_gland_morphology0.67910496
113MP0001293_anophthalmia0.67856434
114MP0005084_abnormal_gallbladder_morpholo0.66886997
115MP0005623_abnormal_meninges_morphology0.63921600
116MP0001986_abnormal_taste_sensitivity0.63799886
117MP0001177_atelectasis0.63761361
118MP0003634_abnormal_glial_cell0.63525291
119MP0001299_abnormal_eye_distance/0.63085723
120MP0004215_abnormal_myocardial_fiber0.62687364
121MP0000026_abnormal_inner_ear0.62374015
122MP0004484_altered_response_of0.61200798
123MP0008877_abnormal_DNA_methylation0.58913187
124MP0001944_abnormal_pancreas_morphology0.57930102
125MP0004885_abnormal_endolymph0.57762432
126MP0001943_abnormal_respiration0.57160390
127MP0002693_abnormal_pancreas_physiology0.56538354
128MP0000015_abnormal_ear_pigmentation0.56514320
129MP0005503_abnormal_tendon_morphology0.55095268
130MP0008872_abnormal_physiological_respon0.54942910
131MP0008004_abnormal_stomach_pH0.53983355
132MP0005448_abnormal_energy_balance0.53620592

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.95862384
2Atonic seizures (HP:0010819)5.69244027
3Epileptic encephalopathy (HP:0200134)5.14711460
4Focal seizures (HP:0007359)4.77111041
5Febrile seizures (HP:0002373)4.52842787
6Visual hallucinations (HP:0002367)4.27279852
7Absence seizures (HP:0002121)4.24988639
8Hyperventilation (HP:0002883)4.05614943
9Myokymia (HP:0002411)3.96664115
10Dialeptic seizures (HP:0011146)3.92074592
11Pheochromocytoma (HP:0002666)3.56743200
12Generalized tonic-clonic seizures (HP:0002069)3.51365562
13Neuroendocrine neoplasm (HP:0100634)3.36826972
14Progressive cerebellar ataxia (HP:0002073)3.36284862
15Abnormality of the corticospinal tract (HP:0002492)3.20716500
16Abnormal hair whorl (HP:0010721)3.13948539
17Polyphagia (HP:0002591)3.07597824
18Gait imbalance (HP:0002141)3.06885244
19Hypothermia (HP:0002045)3.00702290
20Limb dystonia (HP:0002451)2.95340642
21Epileptiform EEG discharges (HP:0011182)2.94307236
22Amblyopia (HP:0000646)2.93176601
23Broad-based gait (HP:0002136)2.89344726
24Failure to thrive in infancy (HP:0001531)2.84274285
25Acute necrotizing encephalopathy (HP:0006965)2.83953512
26Abnormal eating behavior (HP:0100738)2.82302401
27Action tremor (HP:0002345)2.80040868
28Medial flaring of the eyebrow (HP:0010747)2.77221255
29Oligomenorrhea (HP:0000876)2.74574509
30Congenital primary aphakia (HP:0007707)2.74433050
31Abnormal mitochondria in muscle tissue (HP:0008316)2.70090867
32EEG with generalized epileptiform discharges (HP:0011198)2.68157433
33Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.65639553
34Nephrogenic diabetes insipidus (HP:0009806)2.59131660
35Agitation (HP:0000713)2.57427960
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.57272966
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.57272966
38Excessive salivation (HP:0003781)2.56595586
39Drooling (HP:0002307)2.56595586
40Hypoventilation (HP:0002791)2.53181110
41Progressive macrocephaly (HP:0004481)2.48115100
42Hypsarrhythmia (HP:0002521)2.48064504
43Anxiety (HP:0000739)2.46053853
44Truncal ataxia (HP:0002078)2.44721900
45Hyperthyroidism (HP:0000836)2.40213174
46Poor suck (HP:0002033)2.38387888
47Depression (HP:0000716)2.34101849
48Impaired vibration sensation in the lower limbs (HP:0002166)2.33625194
49Gaze-evoked nystagmus (HP:0000640)2.29135709
50Nephronophthisis (HP:0000090)2.28104580
51Absent speech (HP:0001344)2.28054649
52Abnormality of the labia minora (HP:0012880)2.22218534
53Protruding tongue (HP:0010808)2.20270054
54Supranuclear gaze palsy (HP:0000605)2.20242478
55Ulnar claw (HP:0001178)2.20227306
56Blue irides (HP:0000635)2.18422166
57Narrow nasal bridge (HP:0000446)2.14923509
58Abnormality of midbrain morphology (HP:0002418)2.14868350
59Molar tooth sign on MRI (HP:0002419)2.14868350
60Morphological abnormality of the pyramidal tract (HP:0002062)2.13219668
61Dysdiadochokinesis (HP:0002075)2.12535177
62Genital tract atresia (HP:0001827)2.12331096
63True hermaphroditism (HP:0010459)2.11011600
64Ankle clonus (HP:0011448)2.10265188
65Bundle branch block (HP:0011710)2.09396793
66Inability to walk (HP:0002540)2.08742374
67Vaginal atresia (HP:0000148)2.08432591
68Insidious onset (HP:0003587)2.08358725
69Termporal pattern (HP:0011008)2.08358725
70Poor eye contact (HP:0000817)2.06793006
71Impaired smooth pursuit (HP:0007772)2.06744839
72Postaxial hand polydactyly (HP:0001162)2.06608292
73Syncope (HP:0001279)2.06311190
74Esotropia (HP:0000565)2.05717997
75Specific learning disability (HP:0001328)2.05204502
76Urinary urgency (HP:0000012)2.05195208
77Short tibia (HP:0005736)2.04197146
78Decreased circulating renin level (HP:0003351)2.04108629
79Progressive inability to walk (HP:0002505)2.03093629
80Abnormality of the lower motor neuron (HP:0002366)2.02494045
81Urinary bladder sphincter dysfunction (HP:0002839)2.01004750
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.00057011
83Mitochondrial inheritance (HP:0001427)1.99513875
84Acute encephalopathy (HP:0006846)1.99339842
85Akinesia (HP:0002304)1.99170986
86Generalized myoclonic seizures (HP:0002123)1.98953587
87Diplopia (HP:0000651)1.98398790
88Abnormality of binocular vision (HP:0011514)1.98398790
89Menstrual irregularities (HP:0000858)1.97978754
90Aplasia/Hypoplasia of the lens (HP:0008063)1.97953457
91Delayed gross motor development (HP:0002194)1.96169387
92Exotropia (HP:0000577)1.96088075
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.95959404
94Impaired pain sensation (HP:0007328)1.94854069
95Abnormality of pain sensation (HP:0010832)1.94854069
96Resting tremor (HP:0002322)1.94054601
97Pancreatic fibrosis (HP:0100732)1.93618114
98Spastic gait (HP:0002064)1.93428573
99Scanning speech (HP:0002168)1.90988645
100Microglossia (HP:0000171)1.90266472
101Left ventricular hypertrophy (HP:0001712)1.88729418
102Amyotrophic lateral sclerosis (HP:0007354)1.88582414
103Neoplasm of the peripheral nervous system (HP:0100007)1.88352793
104Poor coordination (HP:0002370)1.87873783
105Pancreatic cysts (HP:0001737)1.87869202
106Shoulder girdle muscle weakness (HP:0003547)1.86711500
107Fetal akinesia sequence (HP:0001989)1.84786710
108Bradykinesia (HP:0002067)1.84146961
109Postaxial foot polydactyly (HP:0001830)1.84087735
110Abnormality of calcium-phosphate metabolism (HP:0100530)1.83530103
111Abnormality of the renal medulla (HP:0100957)1.82336389
112Cerebral inclusion bodies (HP:0100314)1.81360538
113Impaired social interactions (HP:0000735)1.81238044
114Abnormal social behavior (HP:0012433)1.81238044
115Oligodactyly (hands) (HP:0001180)1.81178369
116Status epilepticus (HP:0002133)1.80929019
117Hemiparesis (HP:0001269)1.80354877
118Psychosis (HP:0000709)1.79904068
119Genetic anticipation (HP:0003743)1.79507885
120Morphological abnormality of the middle ear (HP:0008609)1.79389378
121Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78040376
122Hypoplasia of the brainstem (HP:0002365)1.78040376
123Broad foot (HP:0001769)1.77050833
124Retinal dysplasia (HP:0007973)1.76124568
125Pachygyria (HP:0001302)1.73583406
126Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73564852
127Abnormality of salivation (HP:0100755)1.73403318
128Sudden death (HP:0001699)1.73313104
129Intestinal atresia (HP:0011100)1.72830283
130Mutism (HP:0002300)1.71777239
131Bradycardia (HP:0001662)1.70781555
132Volvulus (HP:0002580)1.70715421
133Dynein arm defect of respiratory motile cilia (HP:0012255)1.70053467
134Absent/shortened dynein arms (HP:0200106)1.70053467
135Optic disc pallor (HP:0000543)1.69465762
136Dysmetria (HP:0001310)1.69433816
137Increased CSF lactate (HP:0002490)1.68885578
138Generalized hypopigmentation of hair (HP:0011358)1.68516202
139Papillary thyroid carcinoma (HP:0002895)1.66986107
140Chronic hepatic failure (HP:0100626)1.65223250
141Narrow forehead (HP:0000341)1.64366007
142Megalencephaly (HP:0001355)1.64001086
143Spastic tetraplegia (HP:0002510)1.61872335
144Lower limb muscle weakness (HP:0007340)1.60870541
145Atrial fibrillation (HP:0005110)1.60257025
146Cortical dysplasia (HP:0002539)1.59191197
147Tubulointerstitial nephritis (HP:0001970)1.56702167
148Decreased testicular size (HP:0008734)1.53376374
149Sensorimotor neuropathy (HP:0007141)1.52592540
150Concave nail (HP:0001598)1.52517692
151Micropenis (HP:0000054)1.51592296
152Supernumerary spleens (HP:0009799)1.51225299
153Renal hypoplasia (HP:0000089)1.51043841
154Adactyly (HP:0009776)1.50155618
155Lissencephaly (HP:0001339)1.49787700
156Short foot (HP:0001773)1.49378696
157Optic nerve hypoplasia (HP:0000609)1.48470649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.72403927
2NTRK33.67171431
3MAP3K123.04602244
4MAP2K72.99221387
5EPHA42.88891062
6MAP3K42.82564398
7MARK12.80115927
8MAP4K22.72399478
9PLK22.54083636
10MAP3K92.44351778
11MINK12.38881909
12AKT32.38726317
13CCNB12.10242826
14DAPK22.02410698
15TRIM282.01507888
16CDK191.92109782
17MAP2K41.86715769
18SIK31.86103824
19NTRK21.75356209
20DAPK11.75133401
21MAPK131.67864110
22CAMKK21.61387249
23ARAF1.59891804
24GRK51.54670231
25LATS11.51645433
26NTRK11.48126101
27KSR11.43233870
28PIK3CA1.37832332
29PRPF4B1.31830641
30BCR1.29630293
31BRAF1.26200089
32NUAK11.25649376
33PRKCG1.24569738
34TSSK61.24253148
35BMPR21.21947138
36PNCK1.16571000
37CAMK2A1.15652701
38CDK51.15072515
39CSNK1G11.13385368
40OXSR11.12038865
41PINK11.09927074
42WNK31.09868138
43GRK71.07502212
44ERBB31.07268256
45UHMK11.04828311
46TAF11.03714416
47PTK2B1.02157692
48PAK61.02106536
49PDK31.01814388
50PDK41.01814388
51SGK2231.00741134
52SGK4941.00741134
53RIPK40.99338862
54MKNK20.98299143
55NME10.98119441
56SGK20.96815660
57MKNK10.96107795
58CSNK1A1L0.96045169
59STK390.94254282
60CAMK2B0.94205519
61PRKCE0.92694904
62MAP3K20.91497341
63EPHB20.88581081
64CDK180.88173862
65ADRBK10.86774677
66WEE10.86749202
67ADRBK20.85921942
68SIK20.85420018
69CAMKK10.85129467
70BMPR1B0.84755751
71CDK140.83653571
72KSR20.83598740
73TNIK0.81268003
74LATS20.78247210
75CDK150.77293507
76MUSK0.74625237
77INSRR0.73674441
78STK38L0.72560679
79PRKD30.72330497
80SCYL20.70425708
81ROCK20.70362695
82LMTK20.69288298
83PAK30.68106582
84BRSK20.66558796
85LIMK10.66514641
86CDK11A0.63530390
87CSNK1G20.62908754
88PKN10.62193435
89FER0.59449602
90CAMK2D0.58222892
91DYRK1A0.57900592
92DYRK30.53599855
93PDK20.53264742
94NEK10.52970890
95MAPKAPK50.52902308
96RPS6KA40.51169451
97SGK10.51078008
98MYLK0.50380982
99RPS6KA20.50263922
100PKN20.49415844
101VRK10.48924903
102CSNK1D0.47844157
103CDK80.46942549
104MAP2K10.46789575
105BCKDK0.46651752
106DYRK20.46274518
107PHKG10.46111906
108PHKG20.46111906
109SGK30.44666600
110CAMK2G0.44273067
111NEK60.43661351
112FGR0.43213982
113ROCK10.43070398
114PLK40.42281992
115PLK30.41726507
116WNK40.40603534
117FRK0.38381234
118PRKACA0.37613293
119DAPK30.37486862
120TESK10.37456493
121CSNK1E0.36769615
122RET0.36623641
123CAMK10.36549579
124PRKCH0.36159234
125YES10.35974553
126MAP3K10.35526230
127PRKG10.30390370
128FES0.29522141
129CSNK1G30.29039222
130CDK30.28901015
131CDC42BPA0.28623114
132RPS6KA30.26939658
133MAP3K60.25861964
134PRKCZ0.25777514

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98787628
2Synaptic vesicle cycle_Homo sapiens_hsa047213.96590455
3Collecting duct acid secretion_Homo sapiens_hsa049663.43393442
4Vibrio cholerae infection_Homo sapiens_hsa051102.74013070
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67963552
6GABAergic synapse_Homo sapiens_hsa047272.49490861
7Amphetamine addiction_Homo sapiens_hsa050312.41561451
8Morphine addiction_Homo sapiens_hsa050322.37165917
9Circadian entrainment_Homo sapiens_hsa047132.32144651
10Olfactory transduction_Homo sapiens_hsa047402.23067937
11Long-term potentiation_Homo sapiens_hsa047202.21608657
12Insulin secretion_Homo sapiens_hsa049112.20224303
13Oxidative phosphorylation_Homo sapiens_hsa001902.19865237
14Taste transduction_Homo sapiens_hsa047422.19094402
15Dopaminergic synapse_Homo sapiens_hsa047282.09622896
16Glutamatergic synapse_Homo sapiens_hsa047241.99005829
17Serotonergic synapse_Homo sapiens_hsa047261.98041743
18Cocaine addiction_Homo sapiens_hsa050301.75234211
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67966436
20Renin secretion_Homo sapiens_hsa049241.66452786
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66306530
22Long-term depression_Homo sapiens_hsa047301.59055905
23Salivary secretion_Homo sapiens_hsa049701.57771117
24Cholinergic synapse_Homo sapiens_hsa047251.52132374
25Parkinsons disease_Homo sapiens_hsa050121.50082695
26Alzheimers disease_Homo sapiens_hsa050101.46907581
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45908791
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.45467031
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38013941
30Calcium signaling pathway_Homo sapiens_hsa040201.31173098
31Propanoate metabolism_Homo sapiens_hsa006401.28985236
32Gastric acid secretion_Homo sapiens_hsa049711.27739758
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27391562
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26210019
35Oxytocin signaling pathway_Homo sapiens_hsa049211.25866458
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18293132
37Cardiac muscle contraction_Homo sapiens_hsa042601.18061600
38Steroid biosynthesis_Homo sapiens_hsa001001.16123079
39Rheumatoid arthritis_Homo sapiens_hsa053231.16094659
40Gap junction_Homo sapiens_hsa045401.15937434
41Hippo signaling pathway_Homo sapiens_hsa043901.13206704
42Protein export_Homo sapiens_hsa030601.11993497
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.09811244
44Phagosome_Homo sapiens_hsa041451.08628755
45Huntingtons disease_Homo sapiens_hsa050161.02149663
46Basal transcription factors_Homo sapiens_hsa030221.02142231
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00810032
48Hedgehog signaling pathway_Homo sapiens_hsa043401.00385681
49GnRH signaling pathway_Homo sapiens_hsa049120.97999412
50Axon guidance_Homo sapiens_hsa043600.95923740
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92519006
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92348068
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.92094322
54Type II diabetes mellitus_Homo sapiens_hsa049300.90748208
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.90642432
56Phototransduction_Homo sapiens_hsa047440.88916031
57cAMP signaling pathway_Homo sapiens_hsa040240.88836831
58Type I diabetes mellitus_Homo sapiens_hsa049400.88689675
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88346613
60Fatty acid elongation_Homo sapiens_hsa000620.86905787
61Estrogen signaling pathway_Homo sapiens_hsa049150.86751398
62Basal cell carcinoma_Homo sapiens_hsa052170.82575888
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81161984
64Tight junction_Homo sapiens_hsa045300.80886279
65Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78445228
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.77462106
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72760655
68Melanogenesis_Homo sapiens_hsa049160.72572149
69TGF-beta signaling pathway_Homo sapiens_hsa043500.71451945
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70984629
71ErbB signaling pathway_Homo sapiens_hsa040120.69338124
72Nitrogen metabolism_Homo sapiens_hsa009100.68530032
73Thyroid hormone synthesis_Homo sapiens_hsa049180.65667846
74Folate biosynthesis_Homo sapiens_hsa007900.65521945
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65244691
76Prion diseases_Homo sapiens_hsa050200.65013612
77Oocyte meiosis_Homo sapiens_hsa041140.64046173
78Glucagon signaling pathway_Homo sapiens_hsa049220.63277527
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63031739
80Dilated cardiomyopathy_Homo sapiens_hsa054140.63017343
81Glioma_Homo sapiens_hsa052140.62501526
82Alcoholism_Homo sapiens_hsa050340.61037656
83* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58529866
84Circadian rhythm_Homo sapiens_hsa047100.57488372
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55621103
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55127600
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54204063
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53828494
89MAPK signaling pathway_Homo sapiens_hsa040100.53002382
90N-Glycan biosynthesis_Homo sapiens_hsa005100.47905149
91RNA degradation_Homo sapiens_hsa030180.46851181
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46330741
93Pancreatic secretion_Homo sapiens_hsa049720.46146387
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46105249
95Regulation of autophagy_Homo sapiens_hsa041400.45662265
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45585282
97Vitamin B6 metabolism_Homo sapiens_hsa007500.45569445
98Ras signaling pathway_Homo sapiens_hsa040140.45210007
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42416410
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41861672
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39929147
102Ether lipid metabolism_Homo sapiens_hsa005650.39807199
103Peroxisome_Homo sapiens_hsa041460.39796224
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39267668
105Lysosome_Homo sapiens_hsa041420.39152471
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38031841
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37008628
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33834015
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33754686
110Melanoma_Homo sapiens_hsa052180.33420796
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.32450469
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32402301
113Sulfur metabolism_Homo sapiens_hsa009200.32121902
114Ovarian steroidogenesis_Homo sapiens_hsa049130.30246468
115Pyruvate metabolism_Homo sapiens_hsa006200.30204760
116Dorso-ventral axis formation_Homo sapiens_hsa043200.29015507
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27643059
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26664085
119Wnt signaling pathway_Homo sapiens_hsa043100.26591844
120Rap1 signaling pathway_Homo sapiens_hsa040150.25861137
121Insulin signaling pathway_Homo sapiens_hsa049100.25817043
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.23774118
123Butanoate metabolism_Homo sapiens_hsa006500.22834925
124Phenylalanine metabolism_Homo sapiens_hsa003600.22247632

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