ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.34709081
2	respiratory chain complex IV assembly (GO:0008535)	4.67516987
3	cytochrome complex assembly (GO:0017004)	4.65719073
4	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	4.21033738
5	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	4.21033738
6	fucose catabolic process (GO:0019317)	4.15997756
7	L-fucose metabolic process (GO:0042354)	4.15997756
8	L-fucose catabolic process (GO:0042355)	4.15997756
9	natural killer cell activation involved in immune response (GO:0002323)	4.03704107
10	adaptation of signaling pathway (GO:0023058)	3.91921819
11	nucleotide transmembrane transport (GO:1901679)	3.85705362
12	cell wall macromolecule catabolic process (GO:0016998)	3.83866964
13	retinal cone cell development (GO:0046549)	3.73771226
14	signal peptide processing (GO:0006465)	3.70577077
15	protein complex biogenesis (GO:0070271)	3.68549393
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.36161650
17	tryptophan metabolic process (GO:0006568)	3.34271760
18	indolalkylamine metabolic process (GO:0006586)	3.33506450
19	eosinophil chemotaxis (GO:0048245)	3.31153164
20	indolalkylamine catabolic process (GO:0046218)	3.26789111
21	tryptophan catabolic process (GO:0006569)	3.26789111
22	indole-containing compound catabolic process (GO:0042436)	3.26789111
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.20965182
24	establishment of protein localization to Golgi (GO:0072600)	3.20153125
25	cell wall macromolecule metabolic process (GO:0044036)	3.20136038
26	DNA double-strand break processing (GO:0000729)	3.19065444
27	lactate metabolic process (GO:0006089)	3.18831874
28	protein K11-linked deubiquitination (GO:0035871)	3.18595454
29	platelet dense granule organization (GO:0060155)	3.16453537
30	cellular response to exogenous dsRNA (GO:0071360)	3.11281388
31	protein targeting to Golgi (GO:0000042)	3.09054666
32	cytokine biosynthetic process (GO:0042089)	3.05958064
33	positive regulation of protein autophosphorylation (GO:0031954)	3.03333254
34	intestinal epithelial cell development (GO:0060576)	3.02102943
35	inositol phosphate-mediated signaling (GO:0048016)	3.00802716
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99693572
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98018381
38	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98018381
39	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.96642440
40	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.96353311
41	S-adenosylmethionine metabolic process (GO:0046500)	2.96116381
42	eosinophil migration (GO:0072677)	2.95029295
43	branched-chain amino acid catabolic process (GO:0009083)	2.94638085
44	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.92970242
45	phasic smooth muscle contraction (GO:0014821)	2.91543112
46	double-strand break repair via homologous recombination (GO:0000724)	2.88478097
47	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.87325629
48	recombinational repair (GO:0000725)	2.86847875
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.86464466
50	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.86464466
51	NADH dehydrogenase complex assembly (GO:0010257)	2.86464466
52	axoneme assembly (GO:0035082)	2.81665851
53	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75572009
54	reciprocal meiotic recombination (GO:0007131)	2.71210442
55	reciprocal DNA recombination (GO:0035825)	2.71210442
56	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.71126852
57	xenobiotic catabolic process (GO:0042178)	2.69538166
58	centriole replication (GO:0007099)	2.69252713
59	cellular ketone body metabolic process (GO:0046950)	2.68973537
60	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.68160964
61	regulation of hexokinase activity (GO:1903299)	2.66937720
62	regulation of glucokinase activity (GO:0033131)	2.66937720
63	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.66825856
64	polyol catabolic process (GO:0046174)	2.65534028
65	regulation of MHC class I biosynthetic process (GO:0045343)	2.65142033
66	positive regulation of histone H3-K4 methylation (GO:0051571)	2.64470684
67	inositol phosphate catabolic process (GO:0071545)	2.64185510
68	protein localization to Golgi apparatus (GO:0034067)	2.63366625
69	histone H2A ubiquitination (GO:0033522)	2.63105828
70	benzene-containing compound metabolic process (GO:0042537)	2.62700758
71	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.60209462
72	regulation of meiosis I (GO:0060631)	2.59597552
73	C-terminal protein lipidation (GO:0006501)	2.59537009
74	photoreceptor cell maintenance (GO:0045494)	2.58448810
75	protein-cofactor linkage (GO:0018065)	2.57097167
76	photoreceptor cell development (GO:0042461)	2.55175147
77	auditory receptor cell stereocilium organization (GO:0060088)	2.54673545
78	positive regulation of meiosis (GO:0045836)	2.53378796
79	histone mRNA catabolic process (GO:0071044)	2.53364630
80	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.53140833
81	cellular biogenic amine catabolic process (GO:0042402)	2.52478519
82	amine catabolic process (GO:0009310)	2.52478519
83	kidney morphogenesis (GO:0060993)	2.50623965
84	prenylation (GO:0097354)	2.49862190
85	protein prenylation (GO:0018342)	2.49862190
86	arginine catabolic process (GO:0006527)	2.49710726
87	cellular glucuronidation (GO:0052695)	2.47796221
88	detection of light stimulus involved in visual perception (GO:0050908)	2.45942985
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.45942985
90	keratinocyte development (GO:0003334)	2.45070039
91	C-terminal protein amino acid modification (GO:0018410)	2.44806086
92	intra-Golgi vesicle-mediated transport (GO:0006891)	2.44667519
93	glucuronate metabolic process (GO:0019585)	2.44492081
94	uronic acid metabolic process (GO:0006063)	2.44492081
95	replication fork processing (GO:0031297)	2.44107010
96	preassembly of GPI anchor in ER membrane (GO:0016254)	2.43482934
97	DNA deamination (GO:0045006)	2.42482765
98	intraciliary transport (GO:0042073)	2.42212720
99	cytokine metabolic process (GO:0042107)	2.42078358
100	mast cell activation involved in immune response (GO:0002279)	2.41336669

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.33675947
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00303548
3	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.88408471
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.82956458
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.67904651
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.58458647
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.55223162
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.49678619
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40375072
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.36612136
11	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.34290076
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22645561
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.08930918
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.03861085
15	P300_19829295_ChIP-Seq_ESCs_Human	1.99939258
16	VDR_22108803_ChIP-Seq_LS180_Human	1.96771773
17	EWS_26573619_Chip-Seq_HEK293_Human	1.93336371
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88588382
19	FUS_26573619_Chip-Seq_HEK293_Human	1.86860964
20	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.83430074
21	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.83187392
22	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.74502789
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.71807357
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.71707357
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70845369
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.69535443
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68897146
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.66464332
29	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.65624331
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.64239763
31	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.63216894
32	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62524135
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62330152
34	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58401485
35	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.58119491
36	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.56916658
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55129157
38	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.53216522
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.52677248
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.51934736
41	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.47888205
42	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.47768201
43	CDX2_22108803_ChIP-Seq_LS180_Human	1.46146154
44	P53_22387025_ChIP-Seq_ESCs_Mouse	1.46014638
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45674710
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.43410313
47	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.42072709
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39797707
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38031488
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37818834
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37818834
52	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.36245100
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35705974
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.35705974
55	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.34301217
56	P300_18555785_Chip-Seq_ESCs_Mouse	1.34224613
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34042625
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33931909
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33791721
60	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.33400154
61	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.32036163
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.31943709
63	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.31571067
64	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30371478
65	STAT3_23295773_ChIP-Seq_U87_Human	1.28336254
66	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.27333551
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27119968
68	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.26632676
69	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26614704
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26566568
71	AR_25329375_ChIP-Seq_VCAP_Human	1.25531855
72	TCF4_23295773_ChIP-Seq_U87_Human	1.24846482
73	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.24405415
74	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23991533
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22533712
76	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22521900
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22521900
78	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.22128837
79	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21249978
80	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.20869974
81	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.19168434
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16988493
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.16933066
84	TP53_22573176_ChIP-Seq_HFKS_Human	1.16823385
85	VDR_23849224_ChIP-Seq_CD4+_Human	1.15867743
86	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.15760019
87	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.15173691
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12147046
89	GATA3_26560356_Chip-Seq_TH2_Human	1.11880459
90	PHF8_20622853_ChIP-Seq_HELA_Human	1.11084076
91	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10783031
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10198594
93	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09719449
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.09172523
95	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08221579
96	ZFX_18555785_Chip-Seq_ESCs_Mouse	1.08127935
97	CTCF_18555785_Chip-Seq_ESCs_Mouse	1.06864352
98	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06671084
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.05582361
100	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05300022

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.43736030
2	MP0000372_irregular_coat_pigmentation	3.97137350
3	MP0006054_spinal_hemorrhage	3.20097153
4	MP0002876_abnormal_thyroid_physiology	2.57521874
5	MP0002837_dystrophic_cardiac_calcinosis	2.48251145
6	MP0003283_abnormal_digestive_organ	2.41647673
7	MP0009697_abnormal_copulation	2.38829163
8	MP0005084_abnormal_gallbladder_morpholo	2.34932341
9	MP0009780_abnormal_chondrocyte_physiolo	2.30019778
10	MP0002254_reproductive_system_inflammat	2.28048862
11	MP0008877_abnormal_DNA_methylation	2.19057224
12	MP0001986_abnormal_taste_sensitivity	2.08817505
13	MP0005551_abnormal_eye_electrophysiolog	2.06183865
14	MP0005174_abnormal_tail_pigmentation	2.04687422
15	MP0005645_abnormal_hypothalamus_physiol	1.99455324
16	MP0005365_abnormal_bile_salt	1.78364065
17	MP0005379_endocrine/exocrine_gland_phen	1.68983297
18	MP0002938_white_spotting	1.66176186
19	MP0003787_abnormal_imprinting	1.61136715
20	MP0005367_renal/urinary_system_phenotyp	1.58564789
21	MP0000516_abnormal_urinary_system	1.58564789
22	MP0005253_abnormal_eye_physiology	1.58366602
23	MP0005171_absent_coat_pigmentation	1.58192150
24	MP0008872_abnormal_physiological_respon	1.55947172
25	MP0002163_abnormal_gland_morphology	1.55139339
26	MP0000569_abnormal_digit_pigmentation	1.55047159
27	MP0001984_abnormal_olfaction	1.54333503
28	MP0001835_abnormal_antigen_presentation	1.54280817
29	MP0006072_abnormal_retinal_apoptosis	1.53569578
30	MP0004484_altered_response_of	1.53393240
31	MP0005075_abnormal_melanosome_morpholog	1.52075590
32	MP0004134_abnormal_chest_morphology	1.51447536
33	MP0005332_abnormal_amino_acid	1.46564550
34	MP0004215_abnormal_myocardial_fiber	1.45409450
35	MP0000427_abnormal_hair_cycle	1.45312028
36	MP0000538_abnormal_urinary_bladder	1.44904436
37	MP0000013_abnormal_adipose_tissue	1.43961860
38	MP0003186_abnormal_redox_activity	1.43587105
39	MP0000015_abnormal_ear_pigmentation	1.42411788
40	MP0002102_abnormal_ear_morphology	1.42010421
41	MP0003011_delayed_dark_adaptation	1.38288294
42	MP0001756_abnormal_urination	1.36799219
43	MP0002693_abnormal_pancreas_physiology	1.35047872
44	MP0003880_abnormal_central_pattern	1.31619355
45	MP0002166_altered_tumor_susceptibility	1.29764102
46	MP0004043_abnormal_pH_regulation	1.26897572
47	MP0010386_abnormal_urinary_bladder	1.24815548
48	MP0002148_abnormal_hypersensitivity_rea	1.24519726
49	MP0003252_abnormal_bile_duct	1.23579646
50	MP0004142_abnormal_muscle_tone	1.20421223
51	MP0001919_abnormal_reproductive_system	1.18036702
52	MP0004019_abnormal_vitamin_homeostasis	1.13236005
53	MP0003950_abnormal_plasma_membrane	1.12102698
54	MP0002127_abnormal_cardiovascular_syste	1.11597640
55	MP0010329_abnormal_lipoprotein_level	1.11094772
56	MP0009785_altered_susceptibility_to	1.09945554
57	MP0008058_abnormal_DNA_repair	1.09516409
58	MP0005389_reproductive_system_phenotype	1.07057682
59	MP0006082_CNS_inflammation	1.06753734
60	MP0000383_abnormal_hair_follicle	1.06309889
61	MP0003646_muscle_fatigue	1.04540735
62	MP0002095_abnormal_skin_pigmentation	1.04493397
63	MP0005167_abnormal_blood-brain_barrier	0.99758953
64	MP0005636_abnormal_mineral_homeostasis	0.97495594
65	MP0005410_abnormal_fertilization	0.97098222
66	MP0003718_maternal_effect	0.96096412
67	MP0001944_abnormal_pancreas_morphology	0.96074225
68	MP0002909_abnormal_adrenal_gland	0.95878756
69	MP0003172_abnormal_lysosome_physiology	0.95506905
70	MP0002006_tumorigenesis	0.95349750
71	MP0005671_abnormal_response_to	0.94165873
72	MP0006036_abnormal_mitochondrial_physio	0.93021958
73	MP0010678_abnormal_skin_adnexa	0.92411016
74	MP0001968_abnormal_touch/_nociception	0.91718777
75	MP0001666_abnormal_nutrient_absorption	0.91446854
76	MP0002751_abnormal_autonomic_nervous	0.90559776
77	MP0003786_premature_aging	0.88822612
78	MP0003806_abnormal_nucleotide_metabolis	0.86939962
79	MP0002277_abnormal_respiratory_mucosa	0.86842162
80	MP0009745_abnormal_behavioral_response	0.85585563
81	MP0008775_abnormal_heart_ventricle	0.84096802
82	MP0002160_abnormal_reproductive_system	0.84072453
83	MP0009764_decreased_sensitivity_to	0.83544730
84	MP0001485_abnormal_pinna_reflex	0.82930702
85	MP0002638_abnormal_pupillary_reflex	0.81476924
86	MP0005220_abnormal_exocrine_pancreas	0.80863721
87	MP0004084_abnormal_cardiac_muscle	0.80112149
88	MP0000371_diluted_coat_color	0.78218689
89	MP0005646_abnormal_pituitary_gland	0.77082250
90	MP0005387_immune_system_phenotype	0.76843949
91	MP0001790_abnormal_immune_system	0.76843949
92	MP0001929_abnormal_gametogenesis	0.76450115
93	MP0001529_abnormal_vocalization	0.75917858
94	MP0001501_abnormal_sleep_pattern	0.75524067
95	MP0002229_neurodegeneration	0.75244309
96	MP0002295_abnormal_pulmonary_circulatio	0.74377940
97	MP0005310_abnormal_salivary_gland	0.71371739
98	MP0005085_abnormal_gallbladder_physiolo	0.70563079
99	MP0000639_abnormal_adrenal_gland	0.68266809
100	MP0002168_other_aberrant_phenotype	0.66303037

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	3.74318061
2	Pancreatic cysts (HP:0001737)	3.48317682
3	Molar tooth sign on MRI (HP:0002419)	3.33667841
4	Abnormality of midbrain morphology (HP:0002418)	3.33667841
5	Abnormality of the renal cortex (HP:0011035)	3.27423616
6	Pancreatic fibrosis (HP:0100732)	3.19032507
7	Intestinal atresia (HP:0011100)	3.15892218
8	3-Methylglutaconic aciduria (HP:0003535)	2.95159509
9	Volvulus (HP:0002580)	2.90603504
10	Lipid accumulation in hepatocytes (HP:0006561)	2.81381926
11	Nephronophthisis (HP:0000090)	2.79173376
12	Renal cortical cysts (HP:0000803)	2.78761385
13	Attenuation of retinal blood vessels (HP:0007843)	2.75181620
14	Thyroiditis (HP:0100646)	2.74580272
15	True hermaphroditism (HP:0010459)	2.74073783
16	Methylmalonic acidemia (HP:0002912)	2.73565094
17	Type II lissencephaly (HP:0007260)	2.69576901
18	Increased hepatocellular lipid droplets (HP:0006565)	2.69439369
19	Abnormality of the renal medulla (HP:0100957)	2.68795155
20	Hyperventilation (HP:0002883)	2.66355832
21	Abnormality of vitamin B metabolism (HP:0004340)	2.59710440
22	Stomatitis (HP:0010280)	2.53926746
23	Gaze-evoked nystagmus (HP:0000640)	2.53569502
24	Metaphyseal dysplasia (HP:0100255)	2.50993626
25	Disproportionate short-trunk short stature (HP:0003521)	2.41147310
26	Congenital, generalized hypertrichosis (HP:0004540)	2.37649051
27	Progressive macrocephaly (HP:0004481)	2.36410846
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.35743378
29	Congenital stationary night blindness (HP:0007642)	2.33241255
30	Abolished electroretinogram (ERG) (HP:0000550)	2.31278791
31	Increased CSF lactate (HP:0002490)	2.26886880
32	Methylmalonic aciduria (HP:0012120)	2.26408023
33	Keratoconus (HP:0000563)	2.25671924
34	Increased corneal curvature (HP:0100692)	2.25671924
35	Mitochondrial inheritance (HP:0001427)	2.25642333
36	Neoplasm of the adrenal cortex (HP:0100641)	2.24961743
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.24779156
38	Decreased central vision (HP:0007663)	2.18649889
39	Hepatocellular necrosis (HP:0001404)	2.17897614
40	Tubular atrophy (HP:0000092)	2.16953528
41	Hypoplasia of the fovea (HP:0007750)	2.13354370
42	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.13354370
43	Hypoplasia of the pons (HP:0012110)	2.13036716
44	Abnormality of macular pigmentation (HP:0008002)	2.10917042
45	Abnormality of the pons (HP:0007361)	2.09760519
46	Hepatic necrosis (HP:0002605)	2.08455570
47	Tongue fasciculations (HP:0001308)	2.08343496
48	Hypoproteinemia (HP:0003075)	2.08044906
49	Medial flaring of the eyebrow (HP:0010747)	2.07387541
50	Degeneration of anterior horn cells (HP:0002398)	2.06679190
51	Abnormality of the anterior horn cell (HP:0006802)	2.06679190
52	Spinal muscular atrophy (HP:0007269)	2.05889692
53	Hemiparesis (HP:0001269)	2.03930202
54	Pendular nystagmus (HP:0012043)	2.02876949
55	Lissencephaly (HP:0001339)	2.02330314
56	Acute necrotizing encephalopathy (HP:0006965)	2.00783203
57	Widely spaced teeth (HP:0000687)	2.00653420
58	Small hand (HP:0200055)	2.00458897
59	Abnormal biliary tract physiology (HP:0012439)	1.99869102
60	Bile duct proliferation (HP:0001408)	1.99869102
61	Exertional dyspnea (HP:0002875)	1.99486919
62	Abnormality of the prostate (HP:0008775)	1.98944451
63	Stomach cancer (HP:0012126)	1.98683564
64	Abnormal drinking behavior (HP:0030082)	1.96951935
65	Polydipsia (HP:0001959)	1.96951935
66	Abnormality of chromosome stability (HP:0003220)	1.95582088
67	Ketoacidosis (HP:0001993)	1.95349258
68	Hypoalbuminemia (HP:0003073)	1.93816489
69	Abnormal albumin level (HP:0012116)	1.93816489
70	Pancreatic islet-cell hyperplasia (HP:0004510)	1.92511021
71	Constricted visual fields (HP:0001133)	1.90930704
72	Cystic liver disease (HP:0006706)	1.90174108
73	Chronic mucocutaneous candidiasis (HP:0002728)	1.90012178
74	Recurrent cutaneous fungal infections (HP:0011370)	1.90012178
75	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.88257026
76	Prostate neoplasm (HP:0100787)	1.87774040
77	Large for gestational age (HP:0001520)	1.87473447
78	Congenital hepatic fibrosis (HP:0002612)	1.83566827
79	Hypoglycemic coma (HP:0001325)	1.81761349
80	Cone-rod dystrophy (HP:0000548)	1.80590415
81	Abnormality of the fovea (HP:0000493)	1.80080401
82	Oculomotor apraxia (HP:0000657)	1.79837402
83	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.79369737
84	Sloping forehead (HP:0000340)	1.79190037
85	Enlarged penis (HP:0000040)	1.78913161
86	Albinism (HP:0001022)	1.76980318
87	Cerebellar dysplasia (HP:0007033)	1.76824629
88	Renal Fanconi syndrome (HP:0001994)	1.76223428
89	Hyperglycemia (HP:0003074)	1.75508942
90	Hyperinsulinemic hypoglycemia (HP:0000825)	1.75039791
91	Hypokalemic alkalosis (HP:0001949)	1.73837438
92	Polyuria (HP:0000103)	1.72866012
93	Short middle phalanx of the 5th finger (HP:0004220)	1.71431090
94	Metabolic alkalosis (HP:0200114)	1.70579355
95	Abnormality of vitamin metabolism (HP:0100508)	1.69672364
96	Increased serum lactate (HP:0002151)	1.69541133
97	Hematochezia (HP:0002573)	1.69307846
98	Hypoplastic scapulae (HP:0000882)	1.67310764
99	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.67310764
100	Furrowed tongue (HP:0000221)	1.67283827

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.57453696
2	MAP4K2	4.42434665
3	TRIM28	3.38633902
4	INSRR	3.33289601
5	NUAK1	2.73028708
6	MST4	2.52132756
7	EIF2AK3	2.48925515
8	STK39	2.26788302
9	STK24	2.05723501
10	GRK1	2.04145502
11	BMPR1B	2.03868235
12	FER	1.89638133
13	SIK3	1.89304730
14	ADRBK2	1.86709355
15	OXSR1	1.82339208
16	PAK3	1.80185041
17	MAP3K12	1.76579381
18	STK38L	1.65092340
19	TNIK	1.57923970
20	STK16	1.56979508
21	TAOK3	1.55695845
22	AKT3	1.49193078
23	PLK2	1.46661842
24	WNK3	1.42587074
25	MAPK13	1.39952136
26	BCR	1.33552952
27	EIF2AK1	1.30851989
28	TEC	1.26695367
29	ZAK	1.24691513
30	MAP2K6	1.24344827
31	TNK2	1.18325358
32	PIK3CA	1.15948897
33	ACVR1B	1.11000655
34	TXK	1.10330353
35	PRKCE	1.08915633
36	PINK1	1.05331784
37	MKNK2	1.03482708
38	NLK	1.03326771
39	FGFR2	1.02654392
40	TAF1	1.00468819
41	ERBB3	0.99625944
42	PLK3	0.99026703
43	STK3	0.97123303
44	SRPK1	0.95090661
45	WNK4	0.91241402
46	PRKCI	0.84916146
47	BCKDK	0.83720807
48	MAP3K4	0.77715356
49	CSNK1G1	0.77205235
50	MKNK1	0.76248656
51	BRSK2	0.64632410
52	MAPKAPK5	0.62824113
53	ADRBK1	0.57243413
54	JAK1	0.57208858
55	MAPKAPK3	0.57182169
56	VRK2	0.56373744
57	PRKCQ	0.56203675
58	CSNK1G2	0.55033614
59	ITK	0.53016898
60	TLK1	0.52786173
61	CSNK1G3	0.52588032
62	CSNK1A1L	0.52058271
63	FGFR3	0.51838675
64	TRPM7	0.50836918
65	TYK2	0.49756076
66	ABL1	0.49593832
67	CASK	0.49583311
68	IKBKB	0.49100390
69	PRKCG	0.48661528
70	MINK1	0.47376169
71	BUB1	0.46689505
72	IRAK1	0.45342045
73	SGK2	0.43449650
74	MARK3	0.40301495
75	PTK2B	0.38803150
76	PIK3CG	0.38763834
77	TSSK6	0.38758114
78	EIF2AK2	0.37616912
79	VRK1	0.37230365
80	WEE1	0.36415118
81	BTK	0.35092331
82	IGF1R	0.34658268
83	CAMK2D	0.34091909
84	MUSK	0.32421331
85	ATM	0.32320270
86	PRKD3	0.31982519
87	CSNK1A1	0.31655712
88	STK38	0.31353836
89	FGFR1	0.31263059
90	NEK6	0.30924579
91	PLK1	0.30837755
92	PHKG2	0.30159686
93	PHKG1	0.30159686
94	CCNB1	0.29687132
95	FES	0.28768170
96	MAP2K1	0.28156336
97	KSR1	0.27940217
98	PDK2	0.27442492
99	KIT	0.26302247
100	CAMK2A	0.25662344

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.18260277
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.75702513
3	Propanoate metabolism_Homo sapiens_hsa00640	2.71062064
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.55505846
5	Butanoate metabolism_Homo sapiens_hsa00650	2.54738994
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.39170518
7	Homologous recombination_Homo sapiens_hsa03440	2.25541598
8	Proteasome_Homo sapiens_hsa03050	2.18831185
9	Non-homologous end-joining_Homo sapiens_hsa03450	2.13966733
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.13630397
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.10700598
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.93712402
13	Sulfur metabolism_Homo sapiens_hsa00920	1.91597560
14	Phototransduction_Homo sapiens_hsa04744	1.83288708
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79234335
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.75724350
17	Peroxisome_Homo sapiens_hsa04146	1.74207463
18	Basal transcription factors_Homo sapiens_hsa03022	1.72040264
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.68923909
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64455870
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.64435266
22	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.60435224
23	Caffeine metabolism_Homo sapiens_hsa00232	1.55081536
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.54522311
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.52886734
26	RNA degradation_Homo sapiens_hsa03018	1.51393326
27	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.46173357
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.44250459
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.43307077
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36653493
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.35231022
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.33264270
33	Circadian rhythm_Homo sapiens_hsa04710	1.33129790
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.32353538
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.28994229
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.27538961
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27043901
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19932218
39	Retinol metabolism_Homo sapiens_hsa00830	1.15547272
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.10255477
41	Glutathione metabolism_Homo sapiens_hsa00480	1.10144525
42	Fatty acid elongation_Homo sapiens_hsa00062	1.09845378
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07002567
44	Regulation of autophagy_Homo sapiens_hsa04140	1.05529436
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03042660
46	Asthma_Homo sapiens_hsa05310	1.02715313
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.02094719
48	Parkinsons disease_Homo sapiens_hsa05012	1.00104892
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99569587
50	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.96219628
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.90101534
52	RNA polymerase_Homo sapiens_hsa03020	0.89297381
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89203915
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.88481168
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.86495730
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84991732
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82914323
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.82408798
59	Allograft rejection_Homo sapiens_hsa05330	0.81511361
60	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79405602
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78748916
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78475462
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75712605
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.69507009
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67991157
66	Metabolic pathways_Homo sapiens_hsa01100	0.67027065
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66742134
68	Mineral absorption_Homo sapiens_hsa04978	0.66539815
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64781402
70	Fatty acid degradation_Homo sapiens_hsa00071	0.63631497
71	Alzheimers disease_Homo sapiens_hsa05010	0.63474606
72	Olfactory transduction_Homo sapiens_hsa04740	0.62978830
73	Fatty acid metabolism_Homo sapiens_hsa01212	0.62302391
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62260041
75	Steroid biosynthesis_Homo sapiens_hsa00100	0.61084808
76	One carbon pool by folate_Homo sapiens_hsa00670	0.56805044
77	ABC transporters_Homo sapiens_hsa02010	0.56364071
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.55930878
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.54719431
80	Huntingtons disease_Homo sapiens_hsa05016	0.53810786
81	Insulin secretion_Homo sapiens_hsa04911	0.53117992
82	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.49904433
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47973335
84	Fat digestion and absorption_Homo sapiens_hsa04975	0.46761752
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42834662
86	Mismatch repair_Homo sapiens_hsa03430	0.42272009
87	Purine metabolism_Homo sapiens_hsa00230	0.41905659
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41052172
89	Taste transduction_Homo sapiens_hsa04742	0.40077099
90	Salivary secretion_Homo sapiens_hsa04970	0.39476292
91	Nucleotide excision repair_Homo sapiens_hsa03420	0.39172084
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38319200
93	African trypanosomiasis_Homo sapiens_hsa05143	0.37473412
94	Pancreatic secretion_Homo sapiens_hsa04972	0.37023618
95	Lysine degradation_Homo sapiens_hsa00310	0.35146392
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33450202
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33154849
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33102704
99	Folate biosynthesis_Homo sapiens_hsa00790	0.33067039
100	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.31962631

B3GALNT1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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