B3GALT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.96553174
2synaptic vesicle exocytosis (GO:0016079)4.89565549
3vocalization behavior (GO:0071625)4.43493344
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.40488229
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.34532575
6protein localization to synapse (GO:0035418)4.28139102
7regulation of cell communication by electrical coupling (GO:0010649)4.26908783
8glutamate secretion (GO:0014047)4.24670315
9neuron cell-cell adhesion (GO:0007158)4.22032807
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.16898234
11regulation of synaptic vesicle exocytosis (GO:2000300)4.10344129
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02294745
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.01121101
14synaptic vesicle maturation (GO:0016188)4.00638539
15proline transport (GO:0015824)3.96503068
16locomotory exploration behavior (GO:0035641)3.94837117
17glutamate receptor signaling pathway (GO:0007215)3.92317394
18gamma-aminobutyric acid signaling pathway (GO:0007214)3.90123593
19cellular potassium ion homeostasis (GO:0030007)3.84531880
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83364569
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.78863672
22regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.77734276
23regulation of glutamate receptor signaling pathway (GO:1900449)3.75187712
24G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.74785225
25presynaptic membrane assembly (GO:0097105)3.73929460
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72961059
27neurotransmitter-gated ion channel clustering (GO:0072578)3.72300929
28auditory behavior (GO:0031223)3.67464311
29positive regulation of synapse maturation (GO:0090129)3.65990990
30cell communication involved in cardiac conduction (GO:0086065)3.65759775
31neuron-neuron synaptic transmission (GO:0007270)3.61626873
32regulation of synaptic vesicle transport (GO:1902803)3.59974713
33positive regulation of action potential (GO:0045760)3.59944266
34synaptic transmission, glutamatergic (GO:0035249)3.55076210
35exploration behavior (GO:0035640)3.50250811
36membrane assembly (GO:0071709)3.46106904
37innervation (GO:0060384)3.46098801
38synaptic vesicle endocytosis (GO:0048488)3.42043198
39long-term synaptic potentiation (GO:0060291)3.40459362
40response to histamine (GO:0034776)3.40058586
41regulation of cardiac muscle cell contraction (GO:0086004)3.35935352
42presynaptic membrane organization (GO:0097090)3.35074806
43regulation of membrane repolarization (GO:0060306)3.34400526
44neuron recognition (GO:0008038)3.33863289
45neurotransmitter secretion (GO:0007269)3.33321062
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32922729
47cardiac myofibril assembly (GO:0055003)3.32464860
48regulation of actin filament-based movement (GO:1903115)3.31529683
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31068031
50regulation of cAMP-dependent protein kinase activity (GO:2000479)3.27119073
51central nervous system projection neuron axonogenesis (GO:0021952)3.25079707
52layer formation in cerebral cortex (GO:0021819)3.23938021
53pyrimidine nucleobase catabolic process (GO:0006208)3.22336448
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.22224087
55membrane hyperpolarization (GO:0060081)3.20426462
56regulation of dendritic spine development (GO:0060998)3.18067210
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17597383
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17102337
59startle response (GO:0001964)3.16662834
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15771354
61regulation of postsynaptic membrane potential (GO:0060078)3.15133087
62neuronal action potential propagation (GO:0019227)3.14419335
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14137454
64cardiac muscle contraction (GO:0060048)3.13161399
65regulation of sarcomere organization (GO:0060297)3.12416857
66neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.12400122
67axonal fasciculation (GO:0007413)3.12025601
68alanine transport (GO:0032328)3.10250229
69regulation of vesicle fusion (GO:0031338)3.09971849
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08817396
71long-term memory (GO:0007616)3.08221800
72neuronal action potential (GO:0019228)3.07466193
73response to gravity (GO:0009629)3.06942636
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06936504
75C4-dicarboxylate transport (GO:0015740)3.04863179
76regulation of synapse structural plasticity (GO:0051823)3.02954598
77neuromuscular synaptic transmission (GO:0007274)3.02582228
78positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.00516089
79activation of protein kinase A activity (GO:0034199)2.99860656
80cellular response to epinephrine stimulus (GO:0071872)2.99255039
81regulation of neuronal synaptic plasticity (GO:0048168)2.98458095
82negative regulation of dendrite development (GO:2000171)2.96887875
83regulation of relaxation of muscle (GO:1901077)2.95729391
84long term synaptic depression (GO:0060292)2.93936488
85cell communication by electrical coupling (GO:0010644)2.93911330
86regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91526575
87sodium ion export (GO:0071436)2.91232009
88behavioral fear response (GO:0001662)2.90649188
89behavioral defense response (GO:0002209)2.90649188
90regulation of synapse assembly (GO:0051963)2.89712040
91postsynaptic membrane organization (GO:0001941)2.88944090
92mechanosensory behavior (GO:0007638)2.87752590
93detection of calcium ion (GO:0005513)2.87199951
94positive regulation of potassium ion transmembrane transport (GO:1901381)2.86872819
95regulation of synapse maturation (GO:0090128)2.86415421
96response to auditory stimulus (GO:0010996)2.86110678
97positive regulation of membrane potential (GO:0045838)2.85812542
98regulation of synaptic plasticity (GO:0048167)2.85753269
99regulation of action potential (GO:0098900)2.85753208
100neurotransmitter transport (GO:0006836)2.84891679
101myofibril assembly (GO:0030239)2.84162626
102dendritic spine morphogenesis (GO:0060997)2.83957474
103central nervous system neuron axonogenesis (GO:0021955)2.83662139
104regulation of neurotransmitter secretion (GO:0046928)2.82039437
105synapse assembly (GO:0007416)2.81562394
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.80841881
107cerebellar Purkinje cell differentiation (GO:0021702)2.79713958
108gamma-aminobutyric acid transport (GO:0015812)2.79652882
109transmission of nerve impulse (GO:0019226)2.79479584
110cerebellar granule cell differentiation (GO:0021707)2.79372238
111positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79230928
112response to epinephrine (GO:0071871)2.77437979
113membrane depolarization (GO:0051899)2.77403966
114cerebral cortex radially oriented cell migration (GO:0021799)2.76725968
115muscle cell cellular homeostasis (GO:0046716)2.76274409
116regulation of voltage-gated calcium channel activity (GO:1901385)2.74865765
117positive regulation of synaptic transmission (GO:0050806)2.73672692
118membrane depolarization during action potential (GO:0086010)2.73671566
119positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.73299707
120atrial cardiac muscle cell action potential (GO:0086014)2.72540338
121regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.72277896
122cellular sodium ion homeostasis (GO:0006883)2.71958978
123cardiac conduction (GO:0061337)2.71835303
124negative regulation of amino acid transport (GO:0051956)2.71211392
125negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69961917
126nucleobase catabolic process (GO:0046113)2.69769994
127fear response (GO:0042596)2.69394247
128L-amino acid import (GO:0043092)2.69143672
129synapse organization (GO:0050808)2.68888496
130regulation of respiratory system process (GO:0044065)2.68380775
131multicellular organismal signaling (GO:0035637)2.67828908
132dendrite morphogenesis (GO:0048813)2.67490902
133regulation of glycogen (starch) synthase activity (GO:2000465)2.67054717
134response to dietary excess (GO:0002021)2.66999279
135regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64524542
136striatum development (GO:0021756)2.64372760
137L-serine transport (GO:0015825)2.62522378
138learning (GO:0007612)2.61207697
139positive regulation of neurotransmitter secretion (GO:0001956)2.60312956
140negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.60306312
141regulation of protein kinase A signaling (GO:0010738)2.59759169
142regulation of dendritic spine morphogenesis (GO:0061001)2.59018323
143positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.58951823
144potassium ion homeostasis (GO:0055075)2.57527425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80505648
2GBX2_23144817_ChIP-Seq_PC3_Human4.33329727
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88002610
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77242552
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60060153
6SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40057412
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37948255
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37724358
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37724358
10REST_21632747_ChIP-Seq_MESCs_Mouse2.22213206
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22008134
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21010388
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20629401
14TAF15_26573619_Chip-Seq_HEK293_Human2.17072862
15DROSHA_22980978_ChIP-Seq_HELA_Human2.16865239
16* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.16856453
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15173310
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.14068459
19AR_21572438_ChIP-Seq_LNCaP_Human2.12495383
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.09567054
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09083116
22* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02580701
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.99428664
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93011047
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.92904740
26* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91262047
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88250831
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.84287130
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81085114
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.77649945
31* PIAS1_25552417_ChIP-Seq_VCAP_Human1.77314177
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76631695
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76611262
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.76324118
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75588814
36P300_19829295_ChIP-Seq_ESCs_Human1.74161167
37VDR_22108803_ChIP-Seq_LS180_Human1.70989174
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69310838
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.67147993
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57299845
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.55701138
42AR_25329375_ChIP-Seq_VCAP_Human1.54531424
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.54490812
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51469392
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.50689235
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49313432
47IGF1R_20145208_ChIP-Seq_DFB_Human1.47823017
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47659145
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.47621612
50STAT3_23295773_ChIP-Seq_U87_Human1.47460172
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45891038
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45582643
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45484971
54* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45445420
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45226608
56* FUS_26573619_Chip-Seq_HEK293_Human1.44876083
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43482908
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.43388265
59RNF2_27304074_Chip-Seq_NSC_Mouse1.42974072
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42884512
61* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40461790
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40135719
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38665569
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33813337
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33711375
66TCF4_23295773_ChIP-Seq_U87_Human1.32745328
67* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31613685
68BCAT_22108803_ChIP-Seq_LS180_Human1.29745207
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.29484337
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28309030
71* P53_22387025_ChIP-Seq_ESCs_Mouse1.28005170
72* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27269604
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25843312
74ZNF274_21170338_ChIP-Seq_K562_Hela1.25592668
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25412370
76AR_19668381_ChIP-Seq_PC3_Human1.25128895
77* CBX2_27304074_Chip-Seq_ESCs_Mouse1.24824780
78* EWS_26573619_Chip-Seq_HEK293_Human1.24620814
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23470353
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22736918
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22204709
82* ER_23166858_ChIP-Seq_MCF-7_Human1.21773454
83TP53_16413492_ChIP-PET_HCT116_Human1.21349086
84* E2F1_18555785_Chip-Seq_ESCs_Mouse1.21235441
85AHR_22903824_ChIP-Seq_MCF-7_Human1.20529208
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18638317
87* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18619641
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16773995
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16035017
90RUNX2_22187159_ChIP-Seq_PCA_Human1.13770587
91* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12417207
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11720907
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.11471167
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11064315
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10763781
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10242998
97* NFE2_27457419_Chip-Seq_LIVER_Mouse1.09891049
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09091832
99NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09091832
100* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07379111
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06902110
102RXR_22108803_ChIP-Seq_LS180_Human1.06150990
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05408888
104TP53_18474530_ChIP-ChIP_U2OS_Human1.05234453
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04695978
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04695978
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03852106
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.02536531
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00821525
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99113593
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98908513
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98554221
113* CBP_20019798_ChIP-Seq_JUKART_Human0.97839572
114* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97839572
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.97546175
116* KDM2B_26808549_Chip-Seq_REH_Human0.96921603
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.95722471
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94830372
119* TCF4_18268006_ChIP-ChIP_LS174T_Human0.93345132
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92025029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.68344241
2MP0003880_abnormal_central_pattern3.76316423
3MP0003635_abnormal_synaptic_transmissio3.41101127
4MP0002837_dystrophic_cardiac_calcinosis3.16598752
5MP0005670_abnormal_white_adipose2.96699002
6MP0004270_analgesia2.94500921
7MP0002063_abnormal_learning/memory/cond2.82558926
8MP0009745_abnormal_behavioral_response2.81884839
9MP0009046_muscle_twitch2.68712155
10MP0002064_seizures2.67244046
11MP0004130_abnormal_muscle_cell2.51888073
12MP0001501_abnormal_sleep_pattern2.44358082
13MP0004084_abnormal_cardiac_muscle2.42409346
14* MP0002572_abnormal_emotion/affect_behav2.38065797
15MP0009780_abnormal_chondrocyte_physiolo2.32947915
16MP0001968_abnormal_touch/_nociception2.30152226
17* MP0001486_abnormal_startle_reflex2.29414899
18MP0005551_abnormal_eye_electrophysiolog2.15191677
19MP0002272_abnormal_nervous_system2.14319917
20MP0002734_abnormal_mechanical_nocicepti2.13625560
21MP0005666_abnormal_adipose_tissue2.10335374
22MP0000013_abnormal_adipose_tissue2.08155157
23MP0000749_muscle_degeneration2.05553367
24MP0004185_abnormal_adipocyte_glucose2.00973870
25MP0005423_abnormal_somatic_nervous2.00594486
26MP0002876_abnormal_thyroid_physiology1.98342114
27MP0002822_catalepsy1.91019478
28MP0002909_abnormal_adrenal_gland1.86390192
29MP0002067_abnormal_sensory_capabilities1.80843934
30MP0002736_abnormal_nociception_after1.80007749
31MP0001440_abnormal_grooming_behavior1.78680224
32MP0001984_abnormal_olfaction1.77482627
33MP0002234_abnormal_pharynx_morphology1.70017748
34MP0002735_abnormal_chemical_nociception1.69619668
35MP0004924_abnormal_behavior1.69595030
36MP0005386_behavior/neurological_phenoty1.69595030
37MP0004215_abnormal_myocardial_fiber1.61185804
38MP0002090_abnormal_vision1.60375416
39MP0005375_adipose_tissue_phenotype1.59843776
40MP0000778_abnormal_nervous_system1.59073595
41MP0002733_abnormal_thermal_nociception1.57350529
42MP0008569_lethality_at_weaning1.52491164
43MP0001970_abnormal_pain_threshold1.50933357
44MP0002184_abnormal_innervation1.49112454
45MP0001502_abnormal_circadian_rhythm1.47952238
46MP0005645_abnormal_hypothalamus_physiol1.44426911
47MP0004036_abnormal_muscle_relaxation1.38737893
48MP0000751_myopathy1.38191408
49MP0002557_abnormal_social/conspecific_i1.36309859
50MP0005535_abnormal_body_temperature1.36282059
51MP0003950_abnormal_plasma_membrane1.36037002
52MP0006276_abnormal_autonomic_nervous1.35295681
53MP0005187_abnormal_penis_morphology1.33839607
54MP0003879_abnormal_hair_cell1.32243782
55MP0003787_abnormal_imprinting1.30681202
56MP0003633_abnormal_nervous_system1.29287959
57MP0004811_abnormal_neuron_physiology1.26860447
58MP0002972_abnormal_cardiac_muscle1.26630248
59MP0003329_amyloid_beta_deposits1.25753564
60MP0002882_abnormal_neuron_morphology1.22723390
61MP0005646_abnormal_pituitary_gland1.21207083
62MP0000003_abnormal_adipose_tissue1.20593332
63MP0001299_abnormal_eye_distance/1.17787738
64* MP0002066_abnormal_motor_capabilities/c1.17271975
65MP0002638_abnormal_pupillary_reflex1.16513434
66MP0000569_abnormal_digit_pigmentation1.15114974
67MP0010386_abnormal_urinary_bladder1.14719282
68MP0001188_hyperpigmentation1.10752183
69MP0006072_abnormal_retinal_apoptosis1.09119213
70MP0004858_abnormal_nervous_system1.08876876
71MP0004233_abnormal_muscle_weight1.07279560
72MP0004885_abnormal_endolymph1.05612475
73MP0002971_abnormal_brown_adipose1.04537348
74MP0000955_abnormal_spinal_cord1.04242298
75MP0005334_abnormal_fat_pad1.01382789
76MP0004510_myositis1.00496564
77MP0003690_abnormal_glial_cell1.00107650
78MP0005253_abnormal_eye_physiology0.97925771
79MP0008775_abnormal_heart_ventricle0.97789239
80MP0002069_abnormal_eating/drinking_beha0.97622945
81MP0003631_nervous_system_phenotype0.96841745
82MP0002229_neurodegeneration0.96768452
83MP0001177_atelectasis0.96674315
84MP0004087_abnormal_muscle_fiber0.94219984
85MP0003045_fibrosis0.94114446
86MP0001529_abnormal_vocalization0.93820508
87MP0005620_abnormal_muscle_contractility0.93139616
88MP0009115_abnormal_fat_cell0.91784483
89MP0002152_abnormal_brain_morphology0.90884193
90MP0004043_abnormal_pH_regulation0.88373675
91MP0001661_extended_life_span0.88071074
92MP0004484_altered_response_of0.86896297
93MP0005448_abnormal_energy_balance0.86701165
94MP0002751_abnormal_autonomic_nervous0.86532436
95MP0005367_renal/urinary_system_phenotyp0.86282339
96MP0000516_abnormal_urinary_system0.86282339
97MP0002106_abnormal_muscle_physiology0.84753208
98MP0002269_muscular_atrophy0.83371467
99MP0001905_abnormal_dopamine_level0.81925088
100MP0004145_abnormal_muscle_electrophysio0.81893492
101MP0005195_abnormal_posterior_eye0.81127100
102MP0000759_abnormal_skeletal_muscle0.80262173
103MP0004085_abnormal_heartbeat0.78741305
104MP0002752_abnormal_somatic_nervous0.78477129
105MP0001485_abnormal_pinna_reflex0.78312069
106MP0005595_abnormal_vascular_smooth0.78020078
107MP0000750_abnormal_muscle_regeneration0.77975220
108MP0001963_abnormal_hearing_physiology0.77021952
109MP0000631_abnormal_neuroendocrine_gland0.75890458
110MP0004142_abnormal_muscle_tone0.75530852
111MP0005452_abnormal_adipose_tissue0.75055842
112MP0003634_abnormal_glial_cell0.73878170
113MP0005385_cardiovascular_system_phenoty0.72869294
114MP0001544_abnormal_cardiovascular_syste0.72869294
115MP0005369_muscle_phenotype0.72500794
116MP0002108_abnormal_muscle_morphology0.72207942
117MP0003632_abnormal_nervous_system0.72081069
118MP0005171_absent_coat_pigmentation0.71598746
119MP0004742_abnormal_vestibular_system0.71253847
120MP0003183_abnormal_peptide_metabolism0.70701842
121MP0001943_abnormal_respiration0.70351863
122MP0008872_abnormal_physiological_respon0.70307280
123MP0002078_abnormal_glucose_homeostasis0.69849784
124MP0000920_abnormal_myelination0.69798569
125MP0003137_abnormal_impulse_conducting0.68116684
126MP0005330_cardiomyopathy0.67928017
127MP0003279_aneurysm0.67301140
128MP0003122_maternal_imprinting0.67071323
129MP0008874_decreased_physiological_sensi0.66398390
130MP0010329_abnormal_lipoprotein_level0.65516992

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.80864442
2Epileptic encephalopathy (HP:0200134)5.54914559
3Febrile seizures (HP:0002373)5.18480429
4Congenital stationary night blindness (HP:0007642)5.08947292
5Type 2 muscle fiber atrophy (HP:0003554)4.93131588
6Focal seizures (HP:0007359)4.70123550
7Popliteal pterygium (HP:0009756)4.52922453
8Sudden death (HP:0001699)4.50583528
9Visual hallucinations (HP:0002367)4.32403474
10Atonic seizures (HP:0010819)4.27569147
11Absence seizures (HP:0002121)4.22053301
12Muscle fiber atrophy (HP:0100295)4.09917734
13Hyperventilation (HP:0002883)4.07962613
14Oligomenorrhea (HP:0000876)3.98796185
15Central scotoma (HP:0000603)3.77113361
16Fetal akinesia sequence (HP:0001989)3.75405342
17Dialeptic seizures (HP:0011146)3.75337973
18Progressive cerebellar ataxia (HP:0002073)3.75235814
19Bundle branch block (HP:0011710)3.73878577
20Fatigable weakness (HP:0003473)3.70083383
21Abnormality of the neuromuscular junction (HP:0003398)3.70083383
22Generalized tonic-clonic seizures (HP:0002069)3.63028267
23Syncope (HP:0001279)3.60242005
24Myokymia (HP:0002411)3.49248623
25Atrial fibrillation (HP:0005110)3.30319782
26Broad-based gait (HP:0002136)3.26047735
27Drooling (HP:0002307)3.25397383
28Excessive salivation (HP:0003781)3.25397383
29Abnormality of macular pigmentation (HP:0008002)3.22626257
30Amniotic constriction ring (HP:0009775)3.21199260
31Abnormality of placental membranes (HP:0011409)3.21199260
32Primary atrial arrhythmia (HP:0001692)3.20084553
33Weak cry (HP:0001612)3.18765303
34Gowers sign (HP:0003391)3.17062642
35Akinesia (HP:0002304)3.16445460
36Abnormal eating behavior (HP:0100738)3.14507773
37Truncal ataxia (HP:0002078)3.10749627
38Calf muscle hypertrophy (HP:0008981)3.08161407
39Supraventricular tachycardia (HP:0004755)3.02502099
40Polyphagia (HP:0002591)3.01758579
41Limb dystonia (HP:0002451)2.97516114
42Abnormality of the calf musculature (HP:0001430)2.96540241
43Gaze-evoked nystagmus (HP:0000640)2.95289015
44Supraventricular arrhythmia (HP:0005115)2.94614279
45Poor eye contact (HP:0000817)2.92241600
46Epileptiform EEG discharges (HP:0011182)2.88308414
47Hyperthyroidism (HP:0000836)2.86235703
48Absent speech (HP:0001344)2.80192087
49Decreased muscle mass (HP:0003199)2.79831092
50Dysdiadochokinesis (HP:0002075)2.79778229
51Abnormal social behavior (HP:0012433)2.77190626
52Impaired social interactions (HP:0000735)2.77190626
53Action tremor (HP:0002345)2.71076681
54EEG with generalized epileptiform discharges (HP:0011198)2.69272470
55Hemiparesis (HP:0001269)2.65235656
56Muscle hypertrophy of the lower extremities (HP:0008968)2.61507387
57Cerebral inclusion bodies (HP:0100314)2.58376889
58Diplopia (HP:0000651)2.57629062
59Abnormality of binocular vision (HP:0011514)2.57629062
60Amblyopia (HP:0000646)2.54559251
61Gait imbalance (HP:0002141)2.54195560
62Genetic anticipation (HP:0003743)2.53746268
63Depression (HP:0000716)2.52946908
64Left ventricular hypertrophy (HP:0001712)2.52814839
65Hyporeflexia of lower limbs (HP:0002600)2.52545305
66Scotoma (HP:0000575)2.51535919
67Aplasia of the musculature (HP:0100854)2.47561729
68Papilledema (HP:0001085)2.46791702
69Dysmetric saccades (HP:0000641)2.45611914
70Nonprogressive disorder (HP:0003680)2.42150185
71Impaired vibration sensation in the lower limbs (HP:0002166)2.37375149
72Abnormal EKG (HP:0003115)2.36252088
73Hypsarrhythmia (HP:0002521)2.36193467
74Scanning speech (HP:0002168)2.36089354
75Anxiety (HP:0000739)2.35478470
76Supranuclear gaze palsy (HP:0000605)2.32233354
77Cystic hygroma (HP:0000476)2.31263753
78Mutism (HP:0002300)2.29432020
79Ventricular arrhythmia (HP:0004308)2.27761670
80Dysmetria (HP:0001310)2.27672955
81Abnormality of salivation (HP:0100755)2.25273182
82Hemiplegia (HP:0002301)2.23734411
83Neurofibrillary tangles (HP:0002185)2.22454039
84Abnormal hair whorl (HP:0010721)2.21769245
85Blue irides (HP:0000635)2.20908427
86Protruding tongue (HP:0010808)2.20744949
87Poor suck (HP:0002033)2.20518961
88Widely spaced teeth (HP:0000687)2.20461391
89Urinary bladder sphincter dysfunction (HP:0002839)2.17955928
90Impaired smooth pursuit (HP:0007772)2.13834876
91Congenital primary aphakia (HP:0007707)2.12186129
92Postural instability (HP:0002172)2.10598320
93Heart block (HP:0012722)2.09270644
94Bradykinesia (HP:0002067)2.09053536
95Abnormality of the left ventricular outflow tract (HP:0011103)2.08491433
96Subaortic stenosis (HP:0001682)2.08491433
97Medial flaring of the eyebrow (HP:0010747)2.08270274
98Spastic gait (HP:0002064)2.07224939
99Inappropriate behavior (HP:0000719)2.06960941
100Acanthosis nigricans (HP:0000956)2.06477769
101Lipoatrophy (HP:0100578)2.05428848
102Severe visual impairment (HP:0001141)2.04970838
103Progressive inability to walk (HP:0002505)2.04316151
104Easy fatigability (HP:0003388)2.02229852
105Pheochromocytoma (HP:0002666)2.02065092
106Abnormality of ocular smooth pursuit (HP:0000617)1.99584357
107Inability to walk (HP:0002540)1.97600798
108Ventricular fibrillation (HP:0001663)1.96047338
109Malignant hyperthermia (HP:0002047)1.95507397
110Lower limb muscle weakness (HP:0007340)1.94339763
111Abnormality of the corticospinal tract (HP:0002492)1.93506896
112Insulin-resistant diabetes mellitus (HP:0000831)1.93091396
113Nephrogenic diabetes insipidus (HP:0009806)1.88427833
114Pterygium (HP:0001059)1.88107451
115Termporal pattern (HP:0011008)1.86839916
116Insidious onset (HP:0003587)1.86839916
117Intention tremor (HP:0002080)1.85945815
118Prolonged QT interval (HP:0001657)1.85480553
119Abnormal rod and cone electroretinograms (HP:0008323)1.84955244
120Stereotypic behavior (HP:0000733)1.84021700
121Aqueductal stenosis (HP:0002410)1.82920902
122Exotropia (HP:0000577)1.82847304
123Fair hair (HP:0002286)1.81231368
124Gait ataxia (HP:0002066)1.80974158
125Clumsiness (HP:0002312)1.80829290
126Retinal dysplasia (HP:0007973)1.80684309
127Incomplete penetrance (HP:0003829)1.80672652
128Hypoventilation (HP:0002791)1.78079671
129Impaired vibratory sensation (HP:0002495)1.77715345
130Neuroendocrine neoplasm (HP:0100634)1.77154090
131Abnormal atrioventricular conduction (HP:0005150)1.76461001
132Status epilepticus (HP:0002133)1.76338824
133Generalized myoclonic seizures (HP:0002123)1.74984122
134Torticollis (HP:0000473)1.74803315
135Decreased central vision (HP:0007663)1.73088660
136Respiratory insufficiency due to muscle weakness (HP:0002747)1.72499625
137Generalized hypopigmentation of hair (HP:0011358)1.71867226
138Ankle clonus (HP:0011448)1.71074470
139Thin ribs (HP:0000883)1.70171821
140Amyotrophic lateral sclerosis (HP:0007354)1.70069361
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.69890399
142Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69890399
143Exercise-induced myalgia (HP:0003738)1.69160818
144Abnormality of the lower motor neuron (HP:0002366)1.68539231
145Resting tremor (HP:0002322)1.68500879
146Urinary urgency (HP:0000012)1.68303604
147Delayed gross motor development (HP:0002194)1.67855802
148Thyroid-stimulating hormone excess (HP:0002925)1.67149335
149Macroorchidism (HP:0000053)1.66577351
150Depressed nasal tip (HP:0000437)1.64876117
151Steppage gait (HP:0003376)1.63030856
152Metaphyseal dysplasia (HP:0100255)1.62448715

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.94897200
2NTRK33.57633129
3MAP3K43.37027582
4EPHA43.22474099
5MARK13.22045537
6CASK2.96193606
7MAP2K72.84158279
8CAMK1D2.75260722
9CAMK1G2.64542304
10MAP3K92.33594614
11MINK12.07013564
12PAK61.98695492
13MAP2K41.97866866
14PLK21.76581944
15MAP3K121.76329332
16DAPK21.73498784
17NTRK21.72102787
18RIPK41.68545147
19PHKG21.66211013
20PHKG11.66211013
21BCR1.63102197
22UHMK11.62989103
23PRPF4B1.61840826
24MYLK1.61692270
25LIMK11.59371630
26TNIK1.48320258
27KSR11.48290813
28MAPK131.47535459
29GRK51.36999655
30AKT31.31796921
31CDK51.31716895
32INSRR1.30134155
33PRKD31.30062112
34DAPK11.29929835
35LMTK21.27169780
36OBSCN1.23994464
37KSR21.22624123
38CAMKK21.18809942
39CDK191.14856873
40PTK2B1.14803845
41FRK1.14110158
42PDK31.10211435
43PDK41.10211435
44SGK21.10049689
45PNCK1.00665998
46SIK11.00369872
47FES1.00221878
48PRKCG0.99105946
49MAP3K60.98249734
50SGK2230.97237381
51SGK4940.97237381
52DYRK1A0.97196414
53CAMK10.96515275
54STK380.96043676
55NME10.94843162
56CAMKK10.92358904
57CAMK2A0.89514658
58FGFR20.88002986
59EPHA30.87891017
60BMPR1B0.84389904
61DMPK0.83880909
62SIK20.82351805
63SGK10.82233619
64OXSR10.81627253
65PRKCE0.81146596
66NTRK10.80127873
67SGK30.78233270
68FER0.77897291
69MARK20.73826381
70BMPR20.72863994
71PIK3CA0.72664054
72PDK10.72580237
73STK110.72159327
74CSNK1A1L0.71608350
75RIPK10.71104655
76GRK70.70549639
77MAP3K130.70484535
78CAMK2B0.70281898
79PRKCH0.70050973
80MAP3K20.69960655
81RET0.68360663
82ROCK10.68268363
83PAK30.66537693
84CSNK1G10.66474201
85PDPK10.65153498
86MKNK20.64906520
87CSNK1G30.64828258
88CAMK2G0.64579508
89PRKAA20.64100471
90FGR0.64044965
91DYRK20.62448295
92ARAF0.57354329
93PKN10.57011270
94PRKCZ0.56461855
95MAPK120.56190838
96ACVR1B0.55943463
97MAP2K10.55837974
98MAP3K70.55720058
99PRKAA10.54557189
100ROCK20.54378343
101RAF10.54141837
102CDK30.53888771
103WNK30.53724332
104CDK140.52708486
105CDK180.51879220
106GRK10.51560010
107CAMK2D0.51167992
108STK390.49028189
109CDK150.48996785
110RPS6KA30.48818216
111FGFR30.48216650
112CSNK1G20.45901737
113PDK20.45672145
114TYRO30.42621409
115MAP3K50.42618031
116LATS20.42334267
117PINK10.42212244
118ERBB30.41643066
119PRKG10.41095519
120CAMK40.40956686
121PRKACB0.40720784
122PRKACA0.40237165
123TRIM280.40132596
124PRKD10.39757947
125FYN0.39651181
126MAPK100.37655700
127CCNB10.37463424
128ADRBK20.36889109
129CSNK1D0.31493291
130MAP4K20.30022000
131ADRBK10.29774008
132MAPK70.29092680
133PRKCA0.28090441
134CDK11A0.27812123

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.65078170
2Synaptic vesicle cycle_Homo sapiens_hsa047212.82219709
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75835669
4GABAergic synapse_Homo sapiens_hsa047272.67708522
5Morphine addiction_Homo sapiens_hsa050322.53484486
6Circadian entrainment_Homo sapiens_hsa047132.42333427
7Renin secretion_Homo sapiens_hsa049242.20407675
8Olfactory transduction_Homo sapiens_hsa047402.17019970
9Glutamatergic synapse_Homo sapiens_hsa047242.16987769
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.14680930
11Salivary secretion_Homo sapiens_hsa049702.14365874
12Long-term potentiation_Homo sapiens_hsa047202.12879152
13Insulin secretion_Homo sapiens_hsa049111.84112985
14Dopaminergic synapse_Homo sapiens_hsa047281.82508826
15Amphetamine addiction_Homo sapiens_hsa050311.82254252
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78729663
17Fatty acid biosynthesis_Homo sapiens_hsa000611.78695436
18Taste transduction_Homo sapiens_hsa047421.64596376
19Collecting duct acid secretion_Homo sapiens_hsa049661.61860852
20Cholinergic synapse_Homo sapiens_hsa047251.61232258
21Serotonergic synapse_Homo sapiens_hsa047261.57896635
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55373344
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54122254
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52997915
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51666355
26Gastric acid secretion_Homo sapiens_hsa049711.51632610
27Phototransduction_Homo sapiens_hsa047441.51426839
28Oxytocin signaling pathway_Homo sapiens_hsa049211.48750958
29Long-term depression_Homo sapiens_hsa047301.48394429
30Calcium signaling pathway_Homo sapiens_hsa040201.47318421
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42297877
32cAMP signaling pathway_Homo sapiens_hsa040241.35690207
33Type II diabetes mellitus_Homo sapiens_hsa049301.30561542
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23234215
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19012131
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12076234
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10343300
38GnRH signaling pathway_Homo sapiens_hsa049121.06478436
39Cocaine addiction_Homo sapiens_hsa050301.06097050
40Gap junction_Homo sapiens_hsa045401.05104575
41Vibrio cholerae infection_Homo sapiens_hsa051100.99555255
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99217451
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96147932
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.95687561
45Vitamin B6 metabolism_Homo sapiens_hsa007500.94867351
46Glioma_Homo sapiens_hsa052140.93830836
47Axon guidance_Homo sapiens_hsa043600.92759777
48Glycerolipid metabolism_Homo sapiens_hsa005610.92503364
49Dilated cardiomyopathy_Homo sapiens_hsa054140.91519917
50Cardiac muscle contraction_Homo sapiens_hsa042600.89626617
51Glucagon signaling pathway_Homo sapiens_hsa049220.89003626
52ErbB signaling pathway_Homo sapiens_hsa040120.88643891
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87226870
54AMPK signaling pathway_Homo sapiens_hsa041520.85425267
55Circadian rhythm_Homo sapiens_hsa047100.85371648
56Estrogen signaling pathway_Homo sapiens_hsa049150.84468501
57Melanogenesis_Homo sapiens_hsa049160.80849940
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77244737
59PPAR signaling pathway_Homo sapiens_hsa033200.77001116
60Insulin signaling pathway_Homo sapiens_hsa049100.74677592
61Propanoate metabolism_Homo sapiens_hsa006400.73645366
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70739680
63mTOR signaling pathway_Homo sapiens_hsa041500.70481019
64Tight junction_Homo sapiens_hsa045300.70231857
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69731279
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68961089
67Thyroid hormone synthesis_Homo sapiens_hsa049180.66802127
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65228862
69Pancreatic secretion_Homo sapiens_hsa049720.65200193
70Choline metabolism in cancer_Homo sapiens_hsa052310.65116062
71Regulation of autophagy_Homo sapiens_hsa041400.64076353
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63136514
73Bile secretion_Homo sapiens_hsa049760.62716535
74Ovarian steroidogenesis_Homo sapiens_hsa049130.62679677
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.61027743
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.59825539
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59033600
78Fatty acid metabolism_Homo sapiens_hsa012120.57372356
79Pyruvate metabolism_Homo sapiens_hsa006200.55557089
80Ras signaling pathway_Homo sapiens_hsa040140.54389945
81MAPK signaling pathway_Homo sapiens_hsa040100.54358902
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53522857
83Parkinsons disease_Homo sapiens_hsa050120.52889340
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52306847
85Hippo signaling pathway_Homo sapiens_hsa043900.52080955
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51396181
87Dorso-ventral axis formation_Homo sapiens_hsa043200.51017255
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50204536
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.47201924
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46111462
91Inositol phosphate metabolism_Homo sapiens_hsa005620.45852520
92VEGF signaling pathway_Homo sapiens_hsa043700.44446510
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.44259678
94Rap1 signaling pathway_Homo sapiens_hsa040150.43471453
95Alzheimers disease_Homo sapiens_hsa050100.42349572
96Histidine metabolism_Homo sapiens_hsa003400.42051702
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41872051
98Oocyte meiosis_Homo sapiens_hsa041140.39568909
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.39178922
100African trypanosomiasis_Homo sapiens_hsa051430.39118351
101Renal cell carcinoma_Homo sapiens_hsa052110.38974334
102Insulin resistance_Homo sapiens_hsa049310.37559786
103Melanoma_Homo sapiens_hsa052180.37030086
104Endometrial cancer_Homo sapiens_hsa052130.36388865
105Ether lipid metabolism_Homo sapiens_hsa005650.36031080
106Hedgehog signaling pathway_Homo sapiens_hsa043400.34796205
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34773819
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.33378825
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32856945
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32218542
111Butanoate metabolism_Homo sapiens_hsa006500.32032178
112Tryptophan metabolism_Homo sapiens_hsa003800.31796618
113Wnt signaling pathway_Homo sapiens_hsa043100.30669657
114Oxidative phosphorylation_Homo sapiens_hsa001900.30251993
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30196950
116Rheumatoid arthritis_Homo sapiens_hsa053230.29623924
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29461679
118Focal adhesion_Homo sapiens_hsa045100.27927778
119Alcoholism_Homo sapiens_hsa050340.27783277
120Linoleic acid metabolism_Homo sapiens_hsa005910.26114056
121Arginine and proline metabolism_Homo sapiens_hsa003300.25820501
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23269388
123Mineral absorption_Homo sapiens_hsa049780.22381555

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