B3GALT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of membrane-bound glycoproteins. The encoded protein may synthesize type 1 Lewis antigens, which are elevated in gastrointestinal and pancreatic cancers. Alternatively spliced transcript variants have been observed for this gene, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.57384603
2regulation of guanylate cyclase activity (GO:0031282)7.88519309
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.49656952
4intestinal absorption (GO:0050892)7.29822119
5central nervous system myelination (GO:0022010)7.20947099
6axon ensheathment in central nervous system (GO:0032291)7.20947099
7regulation of bile acid biosynthetic process (GO:0070857)6.64186471
8positive regulation of guanylate cyclase activity (GO:0031284)6.04563240
9epoxygenase P450 pathway (GO:0019373)5.80888770
10NADH metabolic process (GO:0006734)5.49596039
11fat-soluble vitamin biosynthetic process (GO:0042362)5.47886408
12lipoprotein transport (GO:0042953)5.40777875
13regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.26761395
14endocrine process (GO:0050886)5.26761395
15regulation of systemic arterial blood pressure by hormone (GO:0001990)5.26761395
16cellular glucuronidation (GO:0052695)5.19494144
17glucuronate metabolic process (GO:0019585)5.17932641
18uronic acid metabolic process (GO:0006063)5.17932641
19regulation of systemic arterial blood pressure (GO:0003073)4.97458335
20regulation of cGMP biosynthetic process (GO:0030826)4.78083923
21receptor guanylyl cyclase signaling pathway (GO:0007168)4.71484842
22hormone catabolic process (GO:0042447)4.69610388
23calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.63883183
24renal system process involved in regulation of blood volume (GO:0001977)4.61041732
25drug metabolic process (GO:0017144)4.56344978
26positive regulation of glycoprotein biosynthetic process (GO:0010560)4.56183298
27sulfate transmembrane transport (GO:1902358)4.54434623
28auditory receptor cell differentiation (GO:0042491)4.51852687
29synaptic vesicle maturation (GO:0016188)4.49487896
30digestion (GO:0007586)4.48661999
31maintenance of gastrointestinal epithelium (GO:0030277)4.44930659
32transcytosis (GO:0045056)4.38315980
33regulation of cellular extravasation (GO:0002691)4.29466713
34positive regulation of respiratory burst (GO:0060267)4.24091280
35bile acid and bile salt transport (GO:0015721)4.21455544
36vitamin transmembrane transport (GO:0035461)4.20713563
37bundle of His cell to Purkinje myocyte communication (GO:0086069)4.16865018
38peptide hormone processing (GO:0016486)4.13916028
39neuronal action potential propagation (GO:0019227)4.13068259
40flavonoid metabolic process (GO:0009812)4.12902080
41fructose metabolic process (GO:0006000)4.08743011
42L-amino acid import (GO:0043092)4.07298313
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05011294
44regulation of cGMP metabolic process (GO:0030823)4.04263492
45O-glycan processing (GO:0016266)4.02470320
46diacylglycerol metabolic process (GO:0046339)4.02338520
47positive regulation of glycoprotein metabolic process (GO:1903020)3.99554645
48vitamin A metabolic process (GO:0006776)3.99235215
49glycine transport (GO:0015816)3.96831314
50kidney morphogenesis (GO:0060993)3.85493023
51homocysteine metabolic process (GO:0050667)3.80543830
52axon ensheathment (GO:0008366)3.78974575
53ensheathment of neurons (GO:0007272)3.78974575
54negative regulation of gene silencing (GO:0060969)3.78163641
55locomotory exploration behavior (GO:0035641)3.78017470
56myelination (GO:0042552)3.76769706
57positive regulation of pseudopodium assembly (GO:0031274)3.74681863
58arginine metabolic process (GO:0006525)3.73095608
59sulfate transport (GO:0008272)3.70470078
60regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69677702
61drug catabolic process (GO:0042737)3.67006706
62regulation of synaptic vesicle exocytosis (GO:2000300)3.66845842
63digestive system process (GO:0022600)3.66711566
64antibacterial humoral response (GO:0019731)3.65406853
65negative regulation of neurotransmitter transport (GO:0051589)3.65248280
66synaptic vesicle exocytosis (GO:0016079)3.63724905
67urea cycle (GO:0000050)3.61038817
68fatty acid elongation (GO:0030497)3.60336603
69vitamin transport (GO:0051180)3.59213247
70peptide catabolic process (GO:0043171)3.58904647
71virion attachment to host cell (GO:0019062)3.58637100
72adhesion of symbiont to host cell (GO:0044650)3.58637100
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.58226942
74cellular potassium ion homeostasis (GO:0030007)3.53144755
75myelin maintenance (GO:0043217)3.51265219
76alkaloid metabolic process (GO:0009820)3.50509519
77sulfur compound transport (GO:0072348)3.49976280
78epithelial structure maintenance (GO:0010669)3.49846599
79positive regulation of cGMP biosynthetic process (GO:0030828)3.48419915
80antimicrobial humoral response (GO:0019730)3.48386277
81neuron cell-cell adhesion (GO:0007158)3.48241525
82vocalization behavior (GO:0071625)3.46035341
83long-chain fatty acid biosynthetic process (GO:0042759)3.46029778
84oligosaccharide biosynthetic process (GO:0009312)3.41241947
85urea metabolic process (GO:0019627)3.40637417
86intestinal epithelial cell development (GO:0060576)3.39998500
87exogenous drug catabolic process (GO:0042738)3.38556099
88regulation of neuronal synaptic plasticity (GO:0048168)3.38192407
89negative regulation of neurotransmitter secretion (GO:0046929)3.38073553
90fat-soluble vitamin metabolic process (GO:0006775)3.36693177
91vitamin biosynthetic process (GO:0009110)3.33912261
92glycerol metabolic process (GO:0006071)3.32887694
93sphingomyelin metabolic process (GO:0006684)3.31950729
94regulation of pseudopodium assembly (GO:0031272)3.29473347
95response to hepatocyte growth factor (GO:0035728)3.29369652
96cellular response to hepatocyte growth factor stimulus (GO:0035729)3.29369652
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.28794340
98purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.28794340
99regulation of vitamin metabolic process (GO:0030656)3.27466255
100potassium ion import (GO:0010107)3.27297436
101regulation of triglyceride catabolic process (GO:0010896)3.26264835
102cobalamin metabolic process (GO:0009235)3.25855080
103adult walking behavior (GO:0007628)3.25197715
104cellular response to nitric oxide (GO:0071732)3.25168951
105glomerulus development (GO:0032835)3.25057628
106sulfation (GO:0051923)3.24186428
107ionotropic glutamate receptor signaling pathway (GO:0035235)3.23184159
108cGMP-mediated signaling (GO:0019934)3.22458978
109glutamate secretion (GO:0014047)3.18916017
110response to histamine (GO:0034776)3.18237640
111transepithelial transport (GO:0070633)3.17609767
112potassium ion homeostasis (GO:0055075)3.17512082
113sodium ion homeostasis (GO:0055078)3.16251315
114neuromuscular process controlling posture (GO:0050884)3.15985246
115drinking behavior (GO:0042756)3.15741739
116cGMP biosynthetic process (GO:0006182)3.15447175
117regulation of synaptic vesicle transport (GO:1902803)3.14850152
118sodium ion export (GO:0071436)3.12702480
119phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.11165575
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10660628
121renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.09980749
122bile acid metabolic process (GO:0008206)3.09347068
123regulation of long-term neuronal synaptic plasticity (GO:0048169)3.09204060
124regulation of cholesterol homeostasis (GO:2000188)3.07568893
125neurotransmitter secretion (GO:0007269)3.07514102
126drug transmembrane transport (GO:0006855)3.07497036
127amino acid import (GO:0043090)3.06915919
128presynaptic membrane organization (GO:0097090)3.06728493
129regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06124612
130citrulline biosynthetic process (GO:0019240)3.04960203
131gamma-aminobutyric acid transport (GO:0015812)3.03505328
132positive regulation of cGMP metabolic process (GO:0030825)3.03459239
133transmission of nerve impulse (GO:0019226)3.03118136
134regulation of protein glycosylation (GO:0060049)3.02458796
135midgut development (GO:0007494)2.99902075
136glomerular filtration (GO:0003094)2.99275184
137very-low-density lipoprotein particle assembly (GO:0034379)2.98746111
138citrulline metabolic process (GO:0000052)2.98745741
139glutamine family amino acid biosynthetic process (GO:0009084)2.98550120
140response to methylmercury (GO:0051597)2.98404829
141auditory behavior (GO:0031223)2.97275768
142neurotransmitter transport (GO:0006836)2.95159745
143peptidyl-tyrosine autophosphorylation (GO:0038083)2.94214476
144positive regulation of membrane potential (GO:0045838)2.93371631
145neuron-neuron synaptic transmission (GO:0007270)2.91348967
146membrane hyperpolarization (GO:0060081)2.89985100
147dendritic spine morphogenesis (GO:0060997)2.89702680
148mechanosensory behavior (GO:0007638)2.87871366
149establishment of mitochondrion localization (GO:0051654)2.84779061
150regulation of synapse structural plasticity (GO:0051823)2.84585011
151neurotransmitter uptake (GO:0001504)2.84516833
152negative regulation of protein localization to cell surface (GO:2000009)2.83544354
153regulation of glutamate receptor signaling pathway (GO:1900449)2.83322353
154regulation of beta-amyloid formation (GO:1902003)2.83238071
155neuronal ion channel clustering (GO:0045161)2.82041540
156neuromuscular process controlling balance (GO:0050885)2.81643590
157negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79525561
158nerve growth factor signaling pathway (GO:0038180)2.78940262
159glutamate receptor signaling pathway (GO:0007215)2.78521972
160positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76951307
161neuron recognition (GO:0008038)2.76686336
162synaptic transmission, glutamatergic (GO:0035249)2.75518969
163long-term memory (GO:0007616)2.74531342
164presynaptic membrane assembly (GO:0097105)2.74507225
165regulation of amyloid precursor protein catabolic process (GO:1902991)2.74392567
166long-term synaptic potentiation (GO:0060291)2.74217152
167neurotransmitter-gated ion channel clustering (GO:0072578)2.72513634
168gamma-aminobutyric acid signaling pathway (GO:0007214)2.70375964
169response to auditory stimulus (GO:0010996)2.69974804
170positive regulation of potassium ion transport (GO:0043268)2.68531478
171regulation of neurotransmitter levels (GO:0001505)2.67212244
172glycosylceramide metabolic process (GO:0006677)2.66667020
173exploration behavior (GO:0035640)2.66645852
174regulation of synaptic plasticity (GO:0048167)2.66399331
175positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65521159
176negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63217811
177protein localization to synapse (GO:0035418)2.62287228
178apical protein localization (GO:0045176)2.61916616
179mating behavior (GO:0007617)2.61052692
180regulation of voltage-gated calcium channel activity (GO:1901385)2.60896109
181oligodendrocyte differentiation (GO:0048709)2.58945852
182adenosine receptor signaling pathway (GO:0001973)2.58939821
183magnesium ion transport (GO:0015693)2.58914936
184regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54474680
185positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.54389839
186regulation of neurotransmitter uptake (GO:0051580)2.53237447
187cerebellar Purkinje cell layer development (GO:0021680)2.52964628
188axonal fasciculation (GO:0007413)2.49363910
189layer formation in cerebral cortex (GO:0021819)2.48325590
190asymmetric protein localization (GO:0008105)2.47186605
191prepulse inhibition (GO:0060134)2.46423319
192positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.46354105
193neuromuscular process (GO:0050905)2.43657160
194positive regulation of synaptic transmission, GABAergic (GO:0032230)2.43470514
195regulation of dendritic spine morphogenesis (GO:0061001)2.43169035
196cyclic nucleotide catabolic process (GO:0009214)2.43077156
197substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.42448033
198substrate-independent telencephalic tangential migration (GO:0021826)2.42448033
199activation of protein kinase A activity (GO:0034199)2.41355323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.69563555
2EZH2_22144423_ChIP-Seq_EOC_Human4.06567386
3GATA4_25053715_ChIP-Seq_YYC3_Human3.18364377
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.17948312
5SOX2_27498859_Chip-Seq_STOMACH_Mouse3.08586553
6GBX2_23144817_ChIP-Seq_PC3_Human2.92063241
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81060535
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.78799489
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73914280
10GATA6_25053715_ChIP-Seq_YYC3_Human2.71800444
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48520216
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42564407
13* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.42279288
14SOX2_20726797_ChIP-Seq_SW620_Human2.41686903
15DROSHA_22980978_ChIP-Seq_HELA_Human2.37196545
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36345606
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.32864927
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32021735
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32021735
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31448785
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27833075
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27224367
23TCF4_18268006_ChIP-ChIP_LS174T_Human2.11711252
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11435213
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06429192
26REST_21632747_ChIP-Seq_MESCs_Mouse2.06054425
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.04181946
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.02632086
29FOXO3_23340844_ChIP-Seq_DLD1_Human2.00812439
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.94796413
31CDX2_22108803_ChIP-Seq_LS180_Human1.94745677
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91248979
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.88999699
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83739018
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.83461152
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.82895667
37AR_21572438_ChIP-Seq_LNCaP_Human1.76835688
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75808118
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.75128793
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74547678
41FOXA1_25552417_ChIP-Seq_VCAP_Human1.69638618
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.69478362
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67552679
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.64432542
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64258232
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64166043
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53980505
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52804599
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48811098
50* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48119886
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46889104
52BCAT_22108803_ChIP-Seq_LS180_Human1.45066407
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44554551
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42237371
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40897077
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39592222
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39417332
58VDR_22108803_ChIP-Seq_LS180_Human1.39262687
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.36275429
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36162570
61SMAD4_21799915_ChIP-Seq_A2780_Human1.35262339
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.35045634
63RXR_22158963_ChIP-Seq_LIVER_Mouse1.34907818
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34087955
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33442834
66TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33346798
67TAF15_26573619_Chip-Seq_HEK293_Human1.32260019
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31648997
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31505399
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30984694
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30251042
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29055130
73PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27749209
74TCF4_22108803_ChIP-Seq_LS180_Human1.27569572
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27186068
76AR_21909140_ChIP-Seq_LNCAP_Human1.26325319
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26238686
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26213893
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.25820082
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25679776
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24356696
82HNF4A_19822575_ChIP-Seq_HepG2_Human1.24280638
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23341353
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21759401
85STAT3_23295773_ChIP-Seq_U87_Human1.21587090
86NANOG_20526341_ChIP-Seq_ESCs_Human1.21478692
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20303583
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19852107
89* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19422993
90* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19318011
91KLF5_25053715_ChIP-Seq_YYC3_Human1.19281700
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17976749
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.17846985
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17750505
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.14856805
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13866457
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13814785
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13442274
99P300_19829295_ChIP-Seq_ESCs_Human1.12805858
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.09192289
101ARNT_22903824_ChIP-Seq_MCF-7_Human1.08981518
102AHR_22903824_ChIP-Seq_MCF-7_Human1.08277813
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07550924
104GATA3_24758297_ChIP-Seq_MCF-7_Human1.07520525
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07423781
106* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07357350
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.07017805
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05773838
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05183883
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03799061
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03256578
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02809219
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02472351
114KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02102795
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.01902828
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01480306
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01285414
118AR_25329375_ChIP-Seq_VCAP_Human1.01211970
119POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00999748
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.00989838
121CEBPB_22108803_ChIP-Seq_LS180_Human1.00562208
122TP63_17297297_ChIP-ChIP_HaCaT_Human1.00314520
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99851490
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99654891
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99513957
126* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99362635
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.99190238
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99103791
129CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98756389
130ER_23166858_ChIP-Seq_MCF-7_Human0.98515439
131PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.98486522
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97859212
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97371404
134FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97191676
135FOXA1_25329375_ChIP-Seq_VCAP_Human0.97191676
136PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96516736
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.96417814
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95794015
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95794015
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95794015
141NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95756621
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95756621
143FUS_26573619_Chip-Seq_HEK293_Human0.95670596
144TCF4_23295773_ChIP-Seq_U87_Human0.95167097
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95081172
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.94960007
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.94654414
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94597184
149RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94418162
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93600609
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92636373
152RUNX2_22187159_ChIP-Seq_PCA_Human0.92334707
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91909684
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91558075
155AR_19668381_ChIP-Seq_PC3_Human0.91380190
156SALL1_21062744_ChIP-ChIP_HESCs_Human0.91143381
157HNFA_21074721_ChIP-Seq_CACO-2_Human0.90795724
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90449303
159* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90215879
160KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89986793
161POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89983091
162RING1B_27294783_Chip-Seq_NPCs_Mouse0.89718518
163AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88478681
164RXR_22108803_ChIP-Seq_LS180_Human0.88367784
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88163594
166NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87351173
167* SMAD3_21741376_ChIP-Seq_HESCs_Human0.86931615
168ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85938246
169NANOG_16153702_ChIP-ChIP_HESCs_Human0.85744301
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85735631
171KDM2B_26808549_Chip-Seq_K562_Human0.85713796
172NFYA_21822215_ChIP-Seq_K562_Human0.85587461
173GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.85105868
174IGF1R_20145208_ChIP-Seq_DFB_Human0.84754153
175EP300_21415370_ChIP-Seq_HL-1_Mouse0.83394826
176UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83253301
177WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83123844
178SMAD4_21741376_ChIP-Seq_EPCs_Human0.82711930
179EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81913504
180MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81367449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.06500982
2MP0004859_abnormal_synaptic_plasticity4.60323172
3MP0001666_abnormal_nutrient_absorption4.47762743
4MP0005085_abnormal_gallbladder_physiolo4.43233627
5MP0003880_abnormal_central_pattern4.30037776
6MP0002139_abnormal_hepatobiliary_system3.67565191
7MP0009379_abnormal_foot_pigmentation3.63155076
8MP0004270_analgesia3.50126597
9MP0005365_abnormal_bile_salt3.45449089
10MP0004147_increased_porphyrin_level3.42679073
11MP0004019_abnormal_vitamin_homeostasis3.39767396
12MP0002822_catalepsy3.39508145
13MP0003635_abnormal_synaptic_transmissio3.24907204
14MP0000920_abnormal_myelination3.06421153
15MP0002064_seizures2.97957749
16MP0002272_abnormal_nervous_system2.87113658
17MP0009745_abnormal_behavioral_response2.82283452
18MP0001486_abnormal_startle_reflex2.77295729
19MP0010352_gastrointestinal_tract_polyps2.66034668
20MP0004043_abnormal_pH_regulation2.62569511
21MP0002063_abnormal_learning/memory/cond2.54717899
22MP0003329_amyloid_beta_deposits2.54585996
23MP0009046_muscle_twitch2.50379933
24MP0001188_hyperpigmentation2.45560317
25MP0004885_abnormal_endolymph2.41745011
26MP0005423_abnormal_somatic_nervous2.31866716
27MP0002734_abnormal_mechanical_nocicepti2.31854209
28MP0003690_abnormal_glial_cell2.29773091
29MP0002572_abnormal_emotion/affect_behav2.27379068
30MP0001529_abnormal_vocalization2.27192893
31MP0001501_abnormal_sleep_pattern2.04619965
32MP0010155_abnormal_intestine_physiology1.99567593
33MP0000490_abnormal_crypts_of1.98912880
34MP0004142_abnormal_muscle_tone1.95545303
35MP0008569_lethality_at_weaning1.89137905
36MP0000013_abnormal_adipose_tissue1.88576944
37MP0000477_abnormal_intestine_morphology1.87433666
38MP0001970_abnormal_pain_threshold1.87293274
39MP0001440_abnormal_grooming_behavior1.85671609
40MP0002254_reproductive_system_inflammat1.85514953
41MP0009840_abnormal_foam_cell1.85071090
42MP0000538_abnormal_urinary_bladder1.84424361
43MP0003718_maternal_effect1.84002705
44MP0003868_abnormal_feces_composition1.82381969
45MP0000566_synostosis1.79942348
46MP0002909_abnormal_adrenal_gland1.79033585
47MP0001968_abnormal_touch/_nociception1.77147933
48MP0002733_abnormal_thermal_nociception1.75542505
49MP0010329_abnormal_lipoprotein_level1.72386288
50MP0000537_abnormal_urethra_morphology1.71251933
51MP0005332_abnormal_amino_acid1.68640121
52MP0003633_abnormal_nervous_system1.66670675
53MP0009780_abnormal_chondrocyte_physiolo1.65343954
54MP0004742_abnormal_vestibular_system1.62891868
55MP0005645_abnormal_hypothalamus_physiol1.61381070
56MP0002067_abnormal_sensory_capabilities1.59405056
57MP0005646_abnormal_pituitary_gland1.56574652
58MP0001905_abnormal_dopamine_level1.55210345
59MP0009643_abnormal_urine_homeostasis1.54381001
60MP0001502_abnormal_circadian_rhythm1.53137008
61MP0003634_abnormal_glial_cell1.51361079
62MP0004782_abnormal_surfactant_physiolog1.50214379
63MP0000778_abnormal_nervous_system1.49713947
64MP0002229_neurodegeneration1.48252251
65MP0005386_behavior/neurological_phenoty1.45644616
66MP0004924_abnormal_behavior1.45644616
67MP0000955_abnormal_spinal_cord1.45444691
68MP0005670_abnormal_white_adipose1.45331771
69MP0005636_abnormal_mineral_homeostasis1.43291193
70MP0003631_nervous_system_phenotype1.43154935
71MP0001485_abnormal_pinna_reflex1.40622782
72MP0002066_abnormal_motor_capabilities/c1.38818793
73MP0000678_abnormal_parathyroid_gland1.36846002
74MP0000604_amyloidosis1.33778625
75MP0002796_impaired_skin_barrier1.33053911
76MP0002557_abnormal_social/conspecific_i1.32542649
77MP0001663_abnormal_digestive_system1.31098974
78MP0002736_abnormal_nociception_after1.30573312
79MP0002735_abnormal_chemical_nociception1.25189673
80MP0001764_abnormal_homeostasis1.25106755
81MP0005171_absent_coat_pigmentation1.24924205
82MP0002882_abnormal_neuron_morphology1.24309050
83MP0003183_abnormal_peptide_metabolism1.23588142
84MP0003693_abnormal_embryo_hatching1.22458749
85MP0003941_abnormal_skin_development1.22380488
86MP0001873_stomach_inflammation1.21136573
87MP0003632_abnormal_nervous_system1.20837643
88MP0005381_digestive/alimentary_phenotyp1.19764824
89MP0004811_abnormal_neuron_physiology1.17906800
90MP0001765_abnormal_ion_homeostasis1.17846327
91MP0001664_abnormal_digestion1.16973113
92MP0003252_abnormal_bile_duct1.16216959
93MP0000230_abnormal_systemic_arterial1.14935384
94MP0000462_abnormal_digestive_system1.14918198
95MP0002098_abnormal_vibrissa_morphology1.14469657
96MP0003283_abnormal_digestive_organ1.12975546
97MP0003879_abnormal_hair_cell1.12488929
98MP0005058_abnormal_lysosome_morphology1.09482608
99MP0001963_abnormal_hearing_physiology1.07632566
100MP0003075_altered_response_to1.05961676
101MP0005409_darkened_coat_color1.05576456
102MP0002184_abnormal_innervation1.03641302
103MP0000003_abnormal_adipose_tissue1.02300981
104MP0002136_abnormal_kidney_physiology1.02049255
105MP0003172_abnormal_lysosome_physiology1.01336487
106MP0004858_abnormal_nervous_system1.00030861
107MP0005167_abnormal_blood-brain_barrier0.99331646
108MP0002138_abnormal_hepatobiliary_system0.97979505
109MP0001756_abnormal_urination0.97793717
110MP0003950_abnormal_plasma_membrane0.97709079
111MP0005551_abnormal_eye_electrophysiolog0.97695217
112MP0010234_abnormal_vibrissa_follicle0.96682217
113MP0003890_abnormal_embryonic-extraembry0.94562831
114MP0005448_abnormal_energy_balance0.90808419
115MP0003195_calcinosis0.89980243
116MP0005310_abnormal_salivary_gland0.89546447
117MP0001177_atelectasis0.89377572
118MP0002876_abnormal_thyroid_physiology0.89248085
119MP0003866_abnormal_defecation0.89054342
120MP0005166_decreased_susceptibility_to0.88160663
121MP0001346_abnormal_lacrimal_gland0.88087861
122MP0002118_abnormal_lipid_homeostasis0.87912087
123MP0010386_abnormal_urinary_bladder0.87554954
124MP0005410_abnormal_fertilization0.86873898
125MP0002069_abnormal_eating/drinking_beha0.86609887
126MP0005501_abnormal_skin_physiology0.86549245
127MP0003119_abnormal_digestive_system0.86332453
128MP0002152_abnormal_brain_morphology0.80297332
129MP0005535_abnormal_body_temperature0.80249605
130MP0000427_abnormal_hair_cycle0.79786982
131MP0010678_abnormal_skin_adnexa0.77265333
132MP0001984_abnormal_olfaction0.75633587
133MP0008260_abnormal_autophagy0.75589701
134MP0004264_abnormal_extraembryonic_tissu0.75381164
135MP0006276_abnormal_autonomic_nervous0.74932429
136MP0008872_abnormal_physiological_respon0.74801770
137MP0002090_abnormal_vision0.71808907
138MP0003122_maternal_imprinting0.71539556
139MP0004957_abnormal_blastocyst_morpholog0.71218691
140MP0000747_muscle_weakness0.71071855
141MP0008874_decreased_physiological_sensi0.70404227
142MP0001299_abnormal_eye_distance/0.69656203
143MP0003787_abnormal_imprinting0.68233251
144MP0001881_abnormal_mammary_gland0.68122212
145MP0002938_white_spotting0.67958290
146MP0008961_abnormal_basal_metabolism0.67313234
147MP0002752_abnormal_somatic_nervous0.66699247
148MP0003137_abnormal_impulse_conducting0.66361720
149MP0003953_abnormal_hormone_level0.64721005
150MP0005174_abnormal_tail_pigmentation0.64191161
151MP0000470_abnormal_stomach_morphology0.63898618
152MP0004085_abnormal_heartbeat0.63074389
153MP0000631_abnormal_neuroendocrine_gland0.62939145
154MP0005395_other_phenotype0.59738007
155MP0000516_abnormal_urinary_system0.58425040
156MP0005367_renal/urinary_system_phenotyp0.58425040
157MP0010307_abnormal_tumor_latency0.58189412
158MP0001293_anophthalmia0.56887491
159MP0002653_abnormal_ependyma_morphology0.56653204
160MP0001849_ear_inflammation0.55078215
161MP0003567_abnormal_fetal_cardiomyocyte0.54183610
162MP0002277_abnormal_respiratory_mucosa0.52007914
163MP0009672_abnormal_birth_weight0.50907889
164MP0003938_abnormal_ear_development0.50162783
165MP0000609_abnormal_liver_physiology0.49373836
166MP0002896_abnormal_bone_mineralization0.48302965
167MP0000467_abnormal_esophagus_morphology0.48150941
168MP0002078_abnormal_glucose_homeostasis0.45877901
169MP0002971_abnormal_brown_adipose0.45728584
170MP0003937_abnormal_limbs/digits/tail_de0.45522202
171MP0009642_abnormal_blood_homeostasis0.44984556
172MP0002163_abnormal_gland_morphology0.44672249
173MP0000377_abnormal_hair_follicle0.44658547
174MP0000383_abnormal_hair_follicle0.44079073

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)9.26691539
2Hydroxyprolinuria (HP:0003080)6.84685492
3Abnormality of proline metabolism (HP:0010907)6.84685492
4Malnutrition (HP:0004395)5.55091856
5Myokymia (HP:0002411)5.51928163
6Abnormality of the vitamin B12 metabolism (HP:0004341)5.31405466
7Abnormality of vitamin B metabolism (HP:0004340)5.15520692
8Neurofibrillary tangles (HP:0002185)5.11948451
9Focal motor seizures (HP:0011153)5.01051845
10Hyperglycinuria (HP:0003108)4.75684549
11Supranuclear gaze palsy (HP:0000605)4.42012828
12Confusion (HP:0001289)4.28340521
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.27236499
14Degeneration of the lateral corticospinal tracts (HP:0002314)4.27236499
15Abnormality of vitamin metabolism (HP:0100508)4.17800060
16Hypobetalipoproteinemia (HP:0003563)4.15103162
17Widely patent fontanelles and sutures (HP:0004492)4.14950321
18Abnormality of serine family amino acid metabolism (HP:0010894)4.09082885
19Abnormality of glycine metabolism (HP:0010895)4.09082885
20Metabolic alkalosis (HP:0200114)4.06897318
21Chronic diarrhea (HP:0002028)4.05744260
22Cerebral inclusion bodies (HP:0100314)3.97670432
23Fat malabsorption (HP:0002630)3.94860815
24Pigmentary retinal degeneration (HP:0001146)3.85756082
25Congenital sensorineural hearing impairment (HP:0008527)3.76888034
26Ankle clonus (HP:0011448)3.75337846
27Action tremor (HP:0002345)3.60524991
28Increased circulating renin level (HP:0000848)3.56607235
29Acanthocytosis (HP:0001927)3.55894280
30Focal seizures (HP:0007359)3.52243072
31Abnormality of the corticospinal tract (HP:0002492)3.51360159
32Peripheral hypomyelination (HP:0007182)3.43544213
33Dysmetria (HP:0001310)3.40979552
34Onion bulb formation (HP:0003383)3.38018451
35Termporal pattern (HP:0011008)3.29309774
36Insidious onset (HP:0003587)3.29309774
37Glycosuria (HP:0003076)3.29150641
38Abnormality of urine glucose concentration (HP:0011016)3.29150641
39Spastic gait (HP:0002064)3.28291252
40Abdominal distention (HP:0003270)3.26966409
41Intention tremor (HP:0002080)3.26152531
42Proximal tubulopathy (HP:0000114)3.13037680
43Right ventricular cardiomyopathy (HP:0011663)3.09161523
44Pheochromocytoma (HP:0002666)3.08659291
45Hepatoblastoma (HP:0002884)3.05786507
46Epileptic encephalopathy (HP:0200134)3.04355858
47Scanning speech (HP:0002168)2.94747734
48Visual hallucinations (HP:0002367)2.89846526
49Hypokalemic alkalosis (HP:0001949)2.86638391
50Nephrolithiasis (HP:0000787)2.86368300
51Abnormal biliary tract morphology (HP:0012440)2.84838026
52Abnormality of renin-angiotensin system (HP:0000847)2.84365204
53Wide cranial sutures (HP:0010537)2.84287035
54Increased purine levels (HP:0004368)2.81320854
55Hyperuricemia (HP:0002149)2.81320854
56Biliary tract neoplasm (HP:0100574)2.81107129
57Megaloblastic anemia (HP:0001889)2.78419226
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77769101
59Abnormality of small intestinal villus morphology (HP:0011472)2.74986696
60Villous atrophy (HP:0011473)2.74986696
61Hyperactive renin-angiotensin system (HP:0000841)2.74682122
62Anxiety (HP:0000739)2.73966796
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.71933301
64Posterior subcapsular cataract (HP:0007787)2.68760740
65Focal segmental glomerulosclerosis (HP:0000097)2.65849224
66Neuroendocrine neoplasm (HP:0100634)2.59538081
67Atonic seizures (HP:0010819)2.59178191
68Hyperaldosteronism (HP:0000859)2.58616671
69Slow saccadic eye movements (HP:0000514)2.58392481
70Megalencephaly (HP:0001355)2.55998364
71Abnormal auditory evoked potentials (HP:0006958)2.55413661
72Dysdiadochokinesis (HP:0002075)2.53649399
73Progressive cerebellar ataxia (HP:0002073)2.51672241
74Facial shape deformation (HP:0011334)2.51374045
75Potter facies (HP:0002009)2.51374045
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48910828
77Urinary urgency (HP:0000012)2.48639507
78Depression (HP:0000716)2.46053884
79Generalized tonic-clonic seizures (HP:0002069)2.45623731
80Abnormal eating behavior (HP:0100738)2.44266953
81Flat acetabular roof (HP:0003180)2.44132402
82Urinary bladder sphincter dysfunction (HP:0002839)2.42396892
83Retinal dysplasia (HP:0007973)2.40886439
84Thickened helices (HP:0000391)2.40711271
85Truncal ataxia (HP:0002078)2.40558753
86Hyperphosphatemia (HP:0002905)2.38979567
87Postural instability (HP:0002172)2.38488886
88Gout (HP:0001997)2.38146158
89Symptomatic seizures (HP:0011145)2.36493740
90Segmental peripheral demyelination/remyelination (HP:0003481)2.36238814
91Dialeptic seizures (HP:0011146)2.34529139
92Broad-based gait (HP:0002136)2.33124337
93Late onset (HP:0003584)2.32042344
94Abnormality of purine metabolism (HP:0004352)2.31816611
95Spastic tetraparesis (HP:0001285)2.31608345
96Intrahepatic cholestasis (HP:0001406)2.31449504
97Steatorrhea (HP:0002570)2.28425882
98Cerebral hypomyelination (HP:0006808)2.27901810
99Abnormality of potassium homeostasis (HP:0011042)2.27090202
100Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.26757076
101Hypomagnesemia (HP:0002917)2.25387975
102Pili torti (HP:0003777)2.24803851
103Axonal loss (HP:0003447)2.23893174
104Torticollis (HP:0000473)2.23659921
105Absence seizures (HP:0002121)2.22755423
106Abnormal albumin level (HP:0012116)2.22117893
107Hypoalbuminemia (HP:0003073)2.22117893
108Neuronal loss in central nervous system (HP:0002529)2.20779430
109Clonus (HP:0002169)2.17984116
110Clumsiness (HP:0002312)2.17319830
111Hypotension (HP:0002615)2.15855509
112Retinal atrophy (HP:0001105)2.15417842
113Lower limb muscle weakness (HP:0007340)2.15176978
114Thin bony cortex (HP:0002753)2.12517151
115Poor eye contact (HP:0000817)2.11866536
116Nausea (HP:0002018)2.09425072
117Diplopia (HP:0000651)2.08924517
118Abnormality of binocular vision (HP:0011514)2.08924517
119Curly hair (HP:0002212)2.08859776
120Hemiparesis (HP:0001269)2.07540905
121Abnormal urine phosphate concentration (HP:0012599)2.07349415
122Impaired vibration sensation in the lower limbs (HP:0002166)2.07023649
123Febrile seizures (HP:0002373)2.06924640
124Papilledema (HP:0001085)2.06469499
125Epidermoid cyst (HP:0200040)2.05948232
126Gaze-evoked nystagmus (HP:0000640)2.05758582
127Hyperammonemia (HP:0001987)2.04768081
128Abnormal pancreas size (HP:0012094)2.04724779
129Xanthomatosis (HP:0000991)2.03808072
130Hyperventilation (HP:0002883)2.03648659
131Hyperphosphaturia (HP:0003109)2.03468921
132Chronic bronchitis (HP:0004469)2.03299922
133Alacrima (HP:0000522)2.01777449
134Impaired social interactions (HP:0000735)2.01658767
135Abnormal social behavior (HP:0012433)2.01658767
136Decreased circulating renin level (HP:0003351)2.01257317
137Aplasia involving bones of the extremities (HP:0009825)2.00508979
138Aplasia involving bones of the upper limbs (HP:0009823)2.00508979
139Aplasia of the phalanges of the hand (HP:0009802)2.00508979
140Abnormality of saccadic eye movements (HP:0000570)1.99558564
141Sensory axonal neuropathy (HP:0003390)1.99069277
142Cerebral hemorrhage (HP:0001342)1.98503336
143Conjugated hyperbilirubinemia (HP:0002908)1.98084184
144Hyperparathyroidism (HP:0000843)1.94658273
145Abnormality of nucleobase metabolism (HP:0010932)1.94523454
146Abnormality of chloride homeostasis (HP:0011422)1.94308762
147Glomerulosclerosis (HP:0000096)1.93671701
148Abnormality of sulfur amino acid metabolism (HP:0004339)1.93633609
149Hypokalemia (HP:0002900)1.93619650
150Hyponatremia (HP:0002902)1.93343333
151Focal dystonia (HP:0004373)1.93264548
152Limb dystonia (HP:0002451)1.92718989
153Subcapsular cataract (HP:0000523)1.91754017
154Metabolic acidosis (HP:0001942)1.90740345
155Hypophosphatemia (HP:0002148)1.90699825
156Dehydration (HP:0001944)1.89485553
157Neoplasm of the small intestine (HP:0100833)1.88977047
158Ileus (HP:0002595)1.88345014
159Ventricular fibrillation (HP:0001663)1.87161617
160Impulsivity (HP:0100710)1.86822732
161Abnormality of calcium-phosphate metabolism (HP:0100530)1.86248141
162Craniofacial dystonia (HP:0012179)1.86067289
163Abnormality of magnesium homeostasis (HP:0004921)1.85712324
164Rigidity (HP:0002063)1.85554443
165Split foot (HP:0001839)1.85375862
166Abnormality of serum amino acid levels (HP:0003112)1.85254524
167Mutism (HP:0002300)1.84747325
168Psychosis (HP:0000709)1.84556095
169Foot dorsiflexor weakness (HP:0009027)1.84333340
170CNS hypomyelination (HP:0003429)1.83490857
171Hypoglycemic seizures (HP:0002173)1.82582313
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.82002885
173Renal tubular acidosis (HP:0001947)1.81515364
174Abnormal glucose tolerance (HP:0001952)1.80064537
175Leukodystrophy (HP:0002415)1.79837533
176Alkalosis (HP:0001948)1.79196598
177Epileptiform EEG discharges (HP:0011182)1.79021607
178Choreoathetosis (HP:0001266)1.78817639
179EEG with generalized epileptiform discharges (HP:0011198)1.78617479
180Neoplasm of the rectum (HP:0100743)1.77602612
181Hyperglycinemia (HP:0002154)1.77102527
182Cerebral palsy (HP:0100021)1.76357813
183Delayed epiphyseal ossification (HP:0002663)1.75989915
184Hypolipoproteinemia (HP:0010981)1.75226630
185Dicarboxylic aciduria (HP:0003215)1.75069598
186Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75069598
187Irritability (HP:0000737)1.72874354
188Bronchomalacia (HP:0002780)1.72763140
189Hyperkalemia (HP:0002153)1.72354985
190Chorioretinal atrophy (HP:0000533)1.71760289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.10209632
2EPHA24.49201035
3STK393.71496522
4EPHA43.40584837
5OXSR13.11919678
6MAP3K102.93590726
7NTRK32.89214496
8RIPK12.76199002
9MAP3K92.68408430
10KSR22.36194440
11MAPKAPK52.28509062
12WNK42.20655254
13NTRK12.11445021
14FRK2.00813612
15PRKD32.00569316
16EPHB21.98566741
17EPHB11.94031999
18WNK11.91355587
19STK241.85183152
20UHMK11.77908954
21MAP3K21.77016651
22SGK2231.75088136
23SGK4941.75088136
24PNCK1.72950181
25NLK1.66984405
26PAK61.65196963
27CAMK2B1.60860943
28MAP3K41.54525631
29ARAF1.54357563
30EPHA31.51438257
31BCR1.49128842
32CDK191.48078204
33MARK11.45963026
34RIPK41.45303694
35PKN11.45297601
36MINK11.44008553
37ERN11.42462894
38MAP3K131.41919368
39CAMK2D1.40988272
40CDK51.38894518
41PTK61.37904172
42DAPK21.36060141
43LIMK11.34555570
44MKNK21.33867971
45STK38L1.32803765
46NTRK21.28131034
47NEK61.26897213
48MET1.25790085
49MST41.20832449
50FGFR21.19953863
51CAMK2G1.17309129
52TTK1.16744085
53FGFR41.14015334
54GRK11.11880268
55CAMK2A1.07727861
56LMTK21.07619231
57MAP2K71.06821901
58CAMKK11.06615951
59STK31.02434164
60MAP3K10.99974879
61LATS10.99558457
62ERBB20.97884711
63TYRO30.96853431
64PAK30.96813520
65NUAK10.95758358
66TNIK0.95412624
67ROCK20.90910609
68PRKCH0.90281969
69CASK0.88374148
70MAPK150.85729369
71FES0.84383724
72PDPK10.82713720
73PINK10.80137955
74PHKG20.80084260
75PHKG10.80084260
76CDK140.79925965
77CDK150.79526554
78INSRR0.76583181
79PRKCE0.76173721
80PRPF4B0.76033445
81CDK180.75809436
82STK110.75638451
83AKT30.74366912
84MARK20.73991689
85CSNK1G20.73724563
86BMPR20.73696954
87GRK50.73374511
88MKNK10.71669092
89MAP2K40.71587150
90TSSK60.71043960
91CAMKK20.70552771
92CDK11A0.68994229
93MST1R0.68352927
94MAP2K20.67906381
95PTK20.67225605
96MUSK0.65853288
97FYN0.63042651
98BRSK20.62729864
99PRKD10.62674557
100SGK10.61960164
101CSNK1G30.61911500
102PDK10.61829278
103CSNK1A1L0.61739474
104IRAK10.61247887
105FGR0.60871916
106WNK30.60133637
107RET0.59561257
108TAOK30.57657241
109MAPK130.56867458
110PRKCZ0.56068120
111HIPK20.55433784
112NME10.55323586
113CSNK1A10.54874384
114CAMK1G0.54103001
115DYRK20.53947189
116CDC42BPA0.53918432
117YES10.53799261
118PRKG20.53100023
119PRKCG0.52722011
120ZAK0.52663968
121DMPK0.51250573
122KSR10.50616490
123FGFR10.50593927
124FER0.50438960
125DYRK1B0.50254865
126PRKCQ0.50217196
127PDK20.49890997
128PRKAA20.49647678
129PRKCA0.49620064
130ALK0.49080808
131MATK0.49005669
132MAP2K10.48683282
133PRKACG0.48422278
134SGK30.48329712
135MELK0.48323130
136PIK3CA0.47756257
137CAMK10.47689628
138CLK10.44531676
139PAK40.43778632
140BMX0.43031854
141MAP3K120.42853096
142PRKCI0.42428202
143STK160.41936550
144TRIM280.40117400
145TAOK10.40003288
146FGFR30.35363281
147BMPR1B0.35247547
148MAP2K60.33146573
149ADRBK20.32206243
150SRC0.31504789
151DDR20.30930669
152NEK20.27998862
153NEK10.27208627
154MYLK0.24986624
155IGF1R0.24654083
156DYRK30.24531795
157TAF10.24151673
158PLK30.22683780
159CSNK1E0.22029067
160ERBB40.21862671
161DAPK10.21024731
162PIM10.20973723
163PRKACA0.18696075
164PLK10.18542905

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.09268377
2Fat digestion and absorption_Homo sapiens_hsa049754.10816909
3Vitamin digestion and absorption_Homo sapiens_hsa049774.02866678
4Renin-angiotensin system_Homo sapiens_hsa046143.60368815
5Caffeine metabolism_Homo sapiens_hsa002322.64376486
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61203440
7Nitrogen metabolism_Homo sapiens_hsa009102.59933006
8Starch and sucrose metabolism_Homo sapiens_hsa005002.45070353
9GABAergic synapse_Homo sapiens_hsa047272.40995969
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35450698
11Protein digestion and absorption_Homo sapiens_hsa049742.34373091
12Synaptic vesicle cycle_Homo sapiens_hsa047212.30275513
13Nicotine addiction_Homo sapiens_hsa050332.20732987
14Arginine biosynthesis_Homo sapiens_hsa002202.18058979
15Sulfur metabolism_Homo sapiens_hsa009202.13861560
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13104255
17Glutamatergic synapse_Homo sapiens_hsa047242.04313008
18Circadian entrainment_Homo sapiens_hsa047132.02970433
19Retinol metabolism_Homo sapiens_hsa008302.01798420
20Morphine addiction_Homo sapiens_hsa050322.01277376
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99105670
22Olfactory transduction_Homo sapiens_hsa047401.95715591
23Salivary secretion_Homo sapiens_hsa049701.91746112
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91425703
25Galactose metabolism_Homo sapiens_hsa000521.88464427
26Gastric acid secretion_Homo sapiens_hsa049711.88051941
27Amphetamine addiction_Homo sapiens_hsa050311.83783553
28Cocaine addiction_Homo sapiens_hsa050301.81761019
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80951747
30Insulin secretion_Homo sapiens_hsa049111.79669679
31Long-term potentiation_Homo sapiens_hsa047201.79492370
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.78817566
33Chemical carcinogenesis_Homo sapiens_hsa052041.73168153
34Fructose and mannose metabolism_Homo sapiens_hsa000511.62998339
35Dopaminergic synapse_Homo sapiens_hsa047281.62089329
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61810939
37Fatty acid elongation_Homo sapiens_hsa000621.56376202
38Long-term depression_Homo sapiens_hsa047301.54349714
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.53819753
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.53093637
41Arginine and proline metabolism_Homo sapiens_hsa003301.51087333
42Collecting duct acid secretion_Homo sapiens_hsa049661.50015262
43Ether lipid metabolism_Homo sapiens_hsa005651.49961079
44Serotonergic synapse_Homo sapiens_hsa047261.49062569
45Renin secretion_Homo sapiens_hsa049241.47458524
46Cholinergic synapse_Homo sapiens_hsa047251.47072955
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43926341
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40255748
49Tryptophan metabolism_Homo sapiens_hsa003801.38792016
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38728163
51Vibrio cholerae infection_Homo sapiens_hsa051101.35822461
52PPAR signaling pathway_Homo sapiens_hsa033201.34757703
53Taste transduction_Homo sapiens_hsa047421.34011937
54Arachidonic acid metabolism_Homo sapiens_hsa005901.33961317
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30385943
56Fatty acid degradation_Homo sapiens_hsa000711.29013390
57Glycerolipid metabolism_Homo sapiens_hsa005611.28865376
58Steroid biosynthesis_Homo sapiens_hsa001001.27392293
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26837360
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24249054
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24119543
62Pancreatic secretion_Homo sapiens_hsa049721.23875896
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21294884
64Butanoate metabolism_Homo sapiens_hsa006501.11921162
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10787763
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08088872
67Mineral absorption_Homo sapiens_hsa049781.07625718
68Calcium signaling pathway_Homo sapiens_hsa040201.05745061
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04087172
70Gap junction_Homo sapiens_hsa045401.03391576
71Oxytocin signaling pathway_Homo sapiens_hsa049211.02867691
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02573915
73Vascular smooth muscle contraction_Homo sapiens_hsa042701.00748043
74cAMP signaling pathway_Homo sapiens_hsa040240.99055287
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97091438
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93583733
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93121757
78GnRH signaling pathway_Homo sapiens_hsa049120.92661371
79Dorso-ventral axis formation_Homo sapiens_hsa043200.90685361
80Thyroid hormone synthesis_Homo sapiens_hsa049180.90643931
81Sphingolipid metabolism_Homo sapiens_hsa006000.90563890
82Axon guidance_Homo sapiens_hsa043600.89775175
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89726227
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89049495
85Type II diabetes mellitus_Homo sapiens_hsa049300.88938607
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.85349413
87Vitamin B6 metabolism_Homo sapiens_hsa007500.83417344
88Glutathione metabolism_Homo sapiens_hsa004800.81750603
89Bile secretion_Homo sapiens_hsa049760.79575196
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78755743
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78545802
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75600812
93Cardiac muscle contraction_Homo sapiens_hsa042600.75340411
94Histidine metabolism_Homo sapiens_hsa003400.75150527
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74035908
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73800212
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.71918470
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70871207
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70493865
100Estrogen signaling pathway_Homo sapiens_hsa049150.69281728
101Fatty acid metabolism_Homo sapiens_hsa012120.69153008
102ErbB signaling pathway_Homo sapiens_hsa040120.68265978
103Oxidative phosphorylation_Homo sapiens_hsa001900.67927882
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.67908585
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67678532
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66476706
107* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65375492
108Alzheimers disease_Homo sapiens_hsa050100.63885444
109Melanogenesis_Homo sapiens_hsa049160.63195175
110Lysosome_Homo sapiens_hsa041420.62462747
111Endocytosis_Homo sapiens_hsa041440.62166800
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.61801968
113Peroxisome_Homo sapiens_hsa041460.61674432
114Phenylalanine metabolism_Homo sapiens_hsa003600.59927275
115Renal cell carcinoma_Homo sapiens_hsa052110.58519478
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58245683
117Inositol phosphate metabolism_Homo sapiens_hsa005620.57662666
118Type I diabetes mellitus_Homo sapiens_hsa049400.56298123
119Tight junction_Homo sapiens_hsa045300.55739451
120Prion diseases_Homo sapiens_hsa050200.55494114
121Propanoate metabolism_Homo sapiens_hsa006400.55407236
122Choline metabolism in cancer_Homo sapiens_hsa052310.53189728
123Linoleic acid metabolism_Homo sapiens_hsa005910.52901511
124Fatty acid biosynthesis_Homo sapiens_hsa000610.52802634
125Ras signaling pathway_Homo sapiens_hsa040140.52155599
126Folate biosynthesis_Homo sapiens_hsa007900.51199459
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48435974
128Glioma_Homo sapiens_hsa052140.47570285
129Ovarian steroidogenesis_Homo sapiens_hsa049130.46076071
130Parkinsons disease_Homo sapiens_hsa050120.44379227
131Selenocompound metabolism_Homo sapiens_hsa004500.44054577
132MAPK signaling pathway_Homo sapiens_hsa040100.42561286
133Pyruvate metabolism_Homo sapiens_hsa006200.41324495
134Dilated cardiomyopathy_Homo sapiens_hsa054140.39748004
135Phototransduction_Homo sapiens_hsa047440.38875168
136* Metabolic pathways_Homo sapiens_hsa011000.38035034
137Protein export_Homo sapiens_hsa030600.36643876
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35906709
139Rap1 signaling pathway_Homo sapiens_hsa040150.35387261
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34522278
141Rheumatoid arthritis_Homo sapiens_hsa053230.33617309
142ABC transporters_Homo sapiens_hsa020100.32141504
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.30728519
144Biosynthesis of amino acids_Homo sapiens_hsa012300.29941589
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28124681
146Glucagon signaling pathway_Homo sapiens_hsa049220.27978359
147Asthma_Homo sapiens_hsa053100.27880907
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.27285659
149Sulfur relay system_Homo sapiens_hsa041220.25652407
150beta-Alanine metabolism_Homo sapiens_hsa004100.25601835
151Adherens junction_Homo sapiens_hsa045200.24377774
152Tyrosine metabolism_Homo sapiens_hsa003500.23179237
153Carbon metabolism_Homo sapiens_hsa012000.18700079
154Insulin resistance_Homo sapiens_hsa049310.17006142
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.16652281
156Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14441473
157Pentose phosphate pathway_Homo sapiens_hsa000300.11920061
158Leukocyte transendothelial migration_Homo sapiens_hsa046700.09483061
159Hepatitis C_Homo sapiens_hsa051600.01180036

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