B3GAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.86597988
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.61851964
3locomotory exploration behavior (GO:0035641)5.40956152
4GDP-mannose metabolic process (GO:0019673)5.32745935
5regulation of synaptic vesicle exocytosis (GO:2000300)5.32289327
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.19587245
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14474410
8glutamate secretion (GO:0014047)4.96373033
9regulation of synaptic vesicle transport (GO:1902803)4.85920560
10mannose metabolic process (GO:0006013)4.82122106
11synaptic vesicle exocytosis (GO:0016079)4.73028325
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.61545533
13negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.44236108
14vocalization behavior (GO:0071625)4.39311198
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38205839
16neurotransmitter secretion (GO:0007269)4.24393196
17sodium ion export (GO:0071436)4.17782354
18neuronal action potential propagation (GO:0019227)4.07012099
19protein maturation by protein folding (GO:0022417)4.03524822
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.95776433
21regulation of glutamate receptor signaling pathway (GO:1900449)3.93476277
22layer formation in cerebral cortex (GO:0021819)3.88637642
23regulation of neuronal synaptic plasticity (GO:0048168)3.88119216
24activation of protein kinase A activity (GO:0034199)3.86996800
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.86847739
26proline transport (GO:0015824)3.86681840
27cellular potassium ion homeostasis (GO:0030007)3.86158833
28exploration behavior (GO:0035640)3.84791027
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.78307880
30Golgi transport vesicle coating (GO:0048200)3.77585996
31COPI coating of Golgi vesicle (GO:0048205)3.77585996
32gamma-aminobutyric acid transport (GO:0015812)3.75535145
33regulation of synapse structural plasticity (GO:0051823)3.75292373
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.74120542
35cell communication by electrical coupling (GO:0010644)3.66490057
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51918786
37protein localization to synapse (GO:0035418)3.50555009
38NIK/NF-kappaB signaling (GO:0038061)3.46293037
39viral protein processing (GO:0019082)3.41776092
40UV protection (GO:0009650)3.35916248
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34866963
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33932638
43neuromuscular process controlling posture (GO:0050884)3.32417488
44synaptic transmission, glutamatergic (GO:0035249)3.30655318
45negative regulation of erythrocyte differentiation (GO:0045647)3.27365527
46neurotransmitter transport (GO:0006836)3.26271712
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23482503
48cerebellar Purkinje cell layer development (GO:0021680)3.23428143
49regulation of vesicle fusion (GO:0031338)3.21522169
50virion assembly (GO:0019068)3.20117284
51metallo-sulfur cluster assembly (GO:0031163)3.19878122
52iron-sulfur cluster assembly (GO:0016226)3.19878122
53neuromuscular process controlling balance (GO:0050885)3.18727854
54regulation of defense response to virus by virus (GO:0050690)3.18100041
55nuclear envelope reassembly (GO:0031468)3.17348828
56mitotic nuclear envelope reassembly (GO:0007084)3.17348828
57regulation of ARF protein signal transduction (GO:0032012)3.17075818
58neurotransmitter-gated ion channel clustering (GO:0072578)3.15372836
59endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.13290163
60glycine transport (GO:0015816)3.11998045
61regulation of neurotransmitter levels (GO:0001505)3.10540075
62regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06124723
63alanine transport (GO:0032328)3.02157488
64proline biosynthetic process (GO:0006561)3.01743065
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01563339
66regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01185451
67negative regulation of cell size (GO:0045792)2.99784897
68cell migration in hindbrain (GO:0021535)2.99471033
69long-term memory (GO:0007616)2.99311666
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97722736
71glutamate receptor signaling pathway (GO:0007215)2.97707752
72regulation of neurotransmitter secretion (GO:0046928)2.96544185
73positive regulation of synapse maturation (GO:0090129)2.95068683
74positive regulation of membrane potential (GO:0045838)2.92809695
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.92007127
76regulation of amyloid precursor protein catabolic process (GO:1902991)2.91535915
77neuron-neuron synaptic transmission (GO:0007270)2.91488131
78amino sugar catabolic process (GO:0046348)2.90848475
79regulation of synaptic plasticity (GO:0048167)2.90179411
80modulation by virus of host process (GO:0019054)2.88582980
81ribosomal small subunit biogenesis (GO:0042274)2.88389766
82potassium ion import (GO:0010107)2.86059187
83dendritic spine morphogenesis (GO:0060997)2.86024569
84cellular sodium ion homeostasis (GO:0006883)2.84325794
85regulation of postsynaptic membrane potential (GO:0060078)2.83272755
86energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83149640
87ATP hydrolysis coupled proton transport (GO:0015991)2.83149640
88synaptic vesicle endocytosis (GO:0048488)2.82783110
89positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81090736
90response to misfolded protein (GO:0051788)2.79060149
91base-excision repair, AP site formation (GO:0006285)2.79015048
92regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78762732
93regulation of extracellular matrix disassembly (GO:0010715)2.78717128
94protein retention in ER lumen (GO:0006621)2.76206189
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.75640501
96protein insertion into membrane (GO:0051205)2.74723558
97regulation of beta-amyloid formation (GO:1902003)2.74218149
98neuron cell-cell adhesion (GO:0007158)2.73367127
99membrane depolarization during action potential (GO:0086010)2.71971499
100positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.71805149
101antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71342537
102cerebellar Purkinje cell differentiation (GO:0021702)2.70754715
103regulation of neurotransmitter transport (GO:0051588)2.69102712
104negative regulation of B cell apoptotic process (GO:0002903)2.68341552
105prepulse inhibition (GO:0060134)2.68272188
106positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.67957254
107viral transcription (GO:0019083)2.67260022
108cell communication involved in cardiac conduction (GO:0086065)2.65781075
109membrane repolarization (GO:0086009)2.65627729
110mating behavior (GO:0007617)2.65388560
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65152374
112positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.64362439
113peptidyl-arginine omega-N-methylation (GO:0035247)2.63410626
114phosphatidylglycerol biosynthetic process (GO:0006655)2.63287618
115activation of MAPKKK activity (GO:0000185)2.61644819
116positive regulation of protein dephosphorylation (GO:0035307)2.60137930
117potassium ion homeostasis (GO:0055075)2.59418483
118negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57820939
119positive regulation of protein homooligomerization (GO:0032464)2.57560238
120positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.57077624
121regulation of clathrin-mediated endocytosis (GO:2000369)2.56684657
122pentose-phosphate shunt (GO:0006098)2.56666583
123phagosome maturation (GO:0090382)2.56381387
124purine deoxyribonucleotide catabolic process (GO:0009155)2.56357266
125thymic T cell selection (GO:0045061)2.56275384
126negative regulation of microtubule polymerization (GO:0031115)2.54851036
127antigen processing and presentation of endogenous antigen (GO:0019883)2.54176932
128transferrin transport (GO:0033572)2.53838435
129positive regulation of lymphocyte apoptotic process (GO:0070230)2.53226540
130vesicle transport along microtubule (GO:0047496)2.52924077
131axon cargo transport (GO:0008088)2.52606994
132regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.52013739
133pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50944333
134response to acidic pH (GO:0010447)2.50908592
135intraspecies interaction between organisms (GO:0051703)2.50874136
136social behavior (GO:0035176)2.50874136
137regulation of ARF GTPase activity (GO:0032312)2.50733428
138neuromuscular process (GO:0050905)2.50716499
139membrane depolarization (GO:0051899)2.50263905
140regulation of dendritic spine morphogenesis (GO:0061001)2.49839984
141amyloid precursor protein catabolic process (GO:0042987)2.49635491
142modulation by symbiont of host cellular process (GO:0044068)2.48473285
143neuronal ion channel clustering (GO:0045161)2.48390376
144positive thymic T cell selection (GO:0045059)2.48337754
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48026176
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.47780910
147mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.47458946
148Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47455232
149dendrite morphogenesis (GO:0048813)2.47350953
150pyrimidine nucleotide catabolic process (GO:0006244)2.46290455
151positive regulation of potassium ion transmembrane transport (GO:1901381)2.46182090
152innervation (GO:0060384)2.45780757
153regulation of synaptic transmission (GO:0050804)2.45541440
154glucose 6-phosphate metabolic process (GO:0051156)2.44448855
1554-hydroxyproline metabolic process (GO:0019471)2.43686783
156positive regulation of neurotransmitter transport (GO:0051590)2.43159735
157suckling behavior (GO:0001967)2.43021063
158glucose catabolic process (GO:0006007)2.42926662
159regulation of sodium ion transmembrane transporter activity (GO:2000649)2.42005428
160regulation of mitochondrial membrane potential (GO:0051881)2.41694975
161signal release (GO:0023061)2.41435914
162regulation of calcium ion-dependent exocytosis (GO:0017158)2.41411094
163adhesion of symbiont to host (GO:0044406)2.40922659
164negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.40639954
165negative regulation of cell killing (GO:0031342)2.40639954
166autophagic vacuole fusion (GO:0000046)2.39982334
167opioid receptor signaling pathway (GO:0038003)2.39814750
168positive regulation of neurotransmitter secretion (GO:0001956)2.38916480
169positive regulation of synaptic transmission (GO:0050806)2.38887094
170barbed-end actin filament capping (GO:0051016)2.38837877
171positive regulation of fibroblast migration (GO:0010763)2.38769339
172guanosine-containing compound biosynthetic process (GO:1901070)2.35271755
173positive regulation of T cell apoptotic process (GO:0070234)2.33528212
174activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.33473650
175maintenance of protein localization in organelle (GO:0072595)2.33328620
176translational elongation (GO:0006414)2.31768429
177regulation of autophagic vacuole assembly (GO:2000785)2.31646966
178deoxyribonucleotide catabolic process (GO:0009264)2.30216863
179regulation of release of cytochrome c from mitochondria (GO:0090199)2.28372959
180modulation by virus of host morphology or physiology (GO:0019048)2.28333492
181retrograde transport, endosome to Golgi (GO:0042147)2.27628514
182T cell apoptotic process (GO:0070231)2.27367008
183positive regulation of mitochondrion organization (GO:0010822)2.26163546
184lipopolysaccharide biosynthetic process (GO:0009103)2.25138407
185positive regulation of TOR signaling (GO:0032008)2.24491423
186regulation of superoxide anion generation (GO:0032928)2.24387423
187regulation of cholesterol biosynthetic process (GO:0045540)2.24182265
188negative regulation of interleukin-2 production (GO:0032703)2.23534431
189negative regulation of tumor necrosis factor production (GO:0032720)2.22089558
190virion attachment to host cell (GO:0019062)2.21661782
191adhesion of symbiont to host cell (GO:0044650)2.21661782
192apoptotic process involved in morphogenesis (GO:0060561)2.21579270
193ferric iron transport (GO:0015682)2.20678359
194trivalent inorganic cation transport (GO:0072512)2.20678359
195positive regulation of nuclease activity (GO:0032075)2.20638346
196negative regulation of innate immune response (GO:0045824)2.20009828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.07534550
2VDR_21846776_ChIP-Seq_THP-1_Human2.92036241
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.86626964
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.74497583
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.69814554
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.68040463
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54667087
8REST_21632747_ChIP-Seq_MESCs_Mouse2.48024364
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44326597
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44326597
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.44238696
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42933808
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41935648
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39891609
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39092564
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38468202
17DROSHA_22980978_ChIP-Seq_HELA_Human2.36257710
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36203545
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.31694910
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27505449
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24775601
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17023934
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16613888
24MYC_22102868_ChIP-Seq_BL_Human2.15692112
25LXR_22292898_ChIP-Seq_THP-1_Human2.15300718
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.11894453
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10129038
28DNAJC2_21179169_ChIP-ChIP_NT2_Human2.07738446
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07655145
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07013017
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05189538
32ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03889942
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.99430672
34KDM2B_26808549_Chip-Seq_K562_Human1.96383483
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94099610
36* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.89105075
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87171689
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.82977719
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81829722
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80447927
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.79351659
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.77761781
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76835366
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73675501
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71995982
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70281407
47BCL6_27268052_Chip-Seq_Bcells_Human1.69798349
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68591570
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67493050
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62384293
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.61953169
52BCOR_27268052_Chip-Seq_Bcells_Human1.61646033
53* MAF_26560356_Chip-Seq_TH2_Human1.60388267
54KDM2B_26808549_Chip-Seq_DND41_Human1.55128477
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54353303
56VDR_24763502_ChIP-Seq_THP-1_Human1.50520018
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49803561
58MAF_26560356_Chip-Seq_TH1_Human1.49482879
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46672489
60* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46085984
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45759634
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45339449
63SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45223699
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45007014
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.42925605
66UTX_26944678_Chip-Seq_JUKART_Human1.40815228
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40516225
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40445000
69CTCF_26484167_Chip-Seq_Bcells_Mouse1.39577610
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38872271
71XRN2_22483619_ChIP-Seq_HELA_Human1.37815913
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.37396745
73ZNF263_19887448_ChIP-Seq_K562_Human1.36869743
74CTCF_27219007_Chip-Seq_Bcells_Human1.36607575
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35492835
76PHF8_20622854_ChIP-Seq_HELA_Human1.34830399
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33857244
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33854042
79RING1B_27294783_Chip-Seq_ESCs_Mouse1.33328824
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33209612
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32881686
82ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29915077
83RARB_24833708_ChIP-Seq_LIVER_Mouse1.29168815
84SMC4_20622854_ChIP-Seq_HELA_Human1.28385095
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.28248684
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27041133
87E2F1_20622854_ChIP-Seq_HELA_Human1.26751380
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26521381
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25704717
90FOXP1_21924763_ChIP-Seq_HESCs_Human1.24867099
91GABP_19822575_ChIP-Seq_HepG2_Human1.24628619
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.24599581
93TP63_17297297_ChIP-ChIP_HaCaT_Human1.23847804
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.22729949
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21196590
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21049344
97* CTCF_20526341_ChIP-Seq_ESCs_Human1.20732040
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.19816178
99TP53_22127205_ChIP-Seq_IMR90_Human1.19657739
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19389377
101PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18340797
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.18252025
103ETS1_20019798_ChIP-Seq_JURKAT_Human1.18025452
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17554441
105EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17251311
106CREB1_26743006_Chip-Seq_LNCaP_Human1.17181949
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15607941
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14747033
109YY1_22570637_ChIP-Seq_MALME-3M_Human1.13736861
110CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13677068
111SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13627321
112P68_20966046_ChIP-Seq_HELA_Human1.11749256
113CTCF_21964334_Chip-Seq_Bcells_Human1.11399997
114* RACK7_27058665_Chip-Seq_MCF-7_Human1.10875050
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10653126
116* RARA_24833708_ChIP-Seq_LIVER_Mouse1.09943497
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09938051
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07571827
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06825032
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.06743198
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05904124
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05713891
123KLF4_19829295_ChIP-Seq_ESCs_Human1.05651311
124NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05595588
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05494492
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04968981
127* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03977939
128TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03943235
129NCOR1_26117541_ChIP-Seq_K562_Human1.03597657
130LXR_22158963_ChIP-Seq_LIVER_Mouse1.03541294
131CIITA_25753668_ChIP-Seq_RAJI_Human1.03360569
132* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03282729
133GBX2_23144817_ChIP-Seq_PC3_Human0.99847548
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96687756
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96638203
136AR_19668381_ChIP-Seq_PC3_Human0.96623423
137RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96248451
138STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96240558
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95045993
140* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94817749
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93921736
142GATA1_19941826_ChIP-Seq_K562_Human0.92800303
143TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92654804
144KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92650481
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91615059
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.91013610
147RING1B_27294783_Chip-Seq_NPCs_Mouse0.90984318
148OCT4_19829295_ChIP-Seq_ESCs_Human0.90711660
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.89143493
150* TET1_21451524_ChIP-Seq_MESCs_Mouse0.88988467
151ELF1_20517297_ChIP-Seq_JURKAT_Human0.88836904
152SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88357465
153* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88008902
154ELK3_25401928_ChIP-Seq_HUVEC_Human0.86251890
155SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85838917
156TP63_22573176_ChIP-Seq_HFKS_Human0.84741814
157NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84277345
158* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83877691
159SOX2_21211035_ChIP-Seq_LN229_Gbm0.83352878
160* SA1_27219007_Chip-Seq_Bcells_Human0.82901510
161TCF7_22412390_ChIP-Seq_EML_Mouse0.82565037
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81137869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.53315240
2MP0005058_abnormal_lysosome_morphology4.87993975
3MP0003635_abnormal_synaptic_transmissio3.78887805
4MP0003880_abnormal_central_pattern3.17735526
5MP0003436_decreased_susceptibility_to3.15851125
6MP0004270_analgesia3.12266864
7MP0002064_seizures2.97060305
8MP0009745_abnormal_behavioral_response2.92011884
9MP0002063_abnormal_learning/memory/cond2.82230587
10MP0001968_abnormal_touch/_nociception2.75219154
11MP0004858_abnormal_nervous_system2.66557932
12MP0002822_catalepsy2.64483387
13MP0008260_abnormal_autophagy2.57773940
14MP0002909_abnormal_adrenal_gland2.54414865
15MP0003329_amyloid_beta_deposits2.48680560
16MP0009046_muscle_twitch2.46281076
17MP0002733_abnormal_thermal_nociception2.30709272
18MP0002736_abnormal_nociception_after2.22471916
19MP0002572_abnormal_emotion/affect_behav2.17843620
20MP0002272_abnormal_nervous_system2.13510165
21MP0002734_abnormal_mechanical_nocicepti2.13358986
22MP0009333_abnormal_splenocyte_physiolog2.12695882
23MP0009278_abnormal_bone_marrow2.09975028
24MP0009780_abnormal_chondrocyte_physiolo2.07715002
25MP0001501_abnormal_sleep_pattern2.00021409
26MP0000685_abnormal_immune_system1.99876091
27MP0002735_abnormal_chemical_nociception1.99061836
28MP0001970_abnormal_pain_threshold1.96897560
29MP0008961_abnormal_basal_metabolism1.96067748
30MP0003123_paternal_imprinting1.90687889
31MP0005451_abnormal_body_composition1.89534347
32MP0003191_abnormal_cellular_cholesterol1.88701892
33MP0001486_abnormal_startle_reflex1.84816349
34MP0006082_CNS_inflammation1.84678994
35MP0005423_abnormal_somatic_nervous1.80586825
36MP0008569_lethality_at_weaning1.74218867
37MP0005025_abnormal_response_to1.74215238
38MP0004811_abnormal_neuron_physiology1.73330816
39MP0001440_abnormal_grooming_behavior1.68293963
40MP0005000_abnormal_immune_tolerance1.65790636
41MP0005387_immune_system_phenotype1.63560296
42MP0001790_abnormal_immune_system1.63560296
43MP0000751_myopathy1.63067844
44MP0003303_peritoneal_inflammation1.62995751
45MP0005671_abnormal_response_to1.57857061
46MP0002067_abnormal_sensory_capabilities1.56927754
47MP0002148_abnormal_hypersensitivity_rea1.56514257
48MP0003879_abnormal_hair_cell1.54672214
49MP0003075_altered_response_to1.53085890
50MP0001348_abnormal_lacrimal_gland1.51811500
51MP0002139_abnormal_hepatobiliary_system1.49953622
52MP0000604_amyloidosis1.49751051
53MP0002419_abnormal_innate_immunity1.49013261
54MP0001533_abnormal_skeleton_physiology1.43992341
55MP0005083_abnormal_biliary_tract1.43274806
56MP0004130_abnormal_muscle_cell1.43228111
57MP0003633_abnormal_nervous_system1.41640543
58MP0001986_abnormal_taste_sensitivity1.40975437
59MP0003283_abnormal_digestive_organ1.40776354
60MP0000955_abnormal_spinal_cord1.39696573
61MP0002723_abnormal_immune_serum1.39408999
62MP0002420_abnormal_adaptive_immunity1.36746465
63MP0004043_abnormal_pH_regulation1.35409708
64MP0002184_abnormal_innervation1.35290256
65MP0001819_abnormal_immune_cell1.34402208
66MP0005386_behavior/neurological_phenoty1.33557566
67MP0004924_abnormal_behavior1.33557566
68MP0000013_abnormal_adipose_tissue1.32790826
69MP0002837_dystrophic_cardiac_calcinosis1.32233912
70MP0002557_abnormal_social/conspecific_i1.30188892
71MP0000681_abnormal_thyroid_gland1.28254946
72MP0003763_abnormal_thymus_physiology1.27154240
73MP0002066_abnormal_motor_capabilities/c1.27053391
74MP0005085_abnormal_gallbladder_physiolo1.26816060
75MP0000920_abnormal_myelination1.26038230
76MP0005360_urolithiasis1.25720533
77MP0000343_altered_response_to1.24921232
78MP0008874_decreased_physiological_sensi1.23541773
79MP0005535_abnormal_body_temperature1.23194128
80MP0010329_abnormal_lipoprotein_level1.23184059
81MP0001873_stomach_inflammation1.20902679
82MP0004510_myositis1.20892598
83MP0002452_abnormal_antigen_presenting1.18997962
84MP0003172_abnormal_lysosome_physiology1.18371418
85MP0005167_abnormal_blood-brain_barrier1.18107346
86MP0005464_abnormal_platelet_physiology1.17149157
87MP0002653_abnormal_ependyma_morphology1.15779368
88MP0001835_abnormal_antigen_presentation1.13795339
89MP0001800_abnormal_humoral_immune1.12961591
90MP0003806_abnormal_nucleotide_metabolis1.11703565
91MP0000858_altered_metastatic_potential1.11592434
92MP0006276_abnormal_autonomic_nervous1.11281394
93MP0002882_abnormal_neuron_morphology1.11121856
94MP0001905_abnormal_dopamine_level1.11107493
95MP0009785_altered_susceptibility_to1.11078016
96MP0001849_ear_inflammation1.10707274
97MP0008469_abnormal_protein_level1.07622537
98MP0000716_abnormal_immune_system1.06380513
99MP0003300_gastrointestinal_ulcer1.05698556
100MP0003631_nervous_system_phenotype1.05315983
101MP0001845_abnormal_inflammatory_respons1.02470024
102MP0004145_abnormal_muscle_electrophysio1.00908844
103MP0004885_abnormal_endolymph1.00727533
104MP0008872_abnormal_physiological_respon1.00457626
105MP0002877_abnormal_melanocyte_morpholog1.00366782
106MP0003705_abnormal_hypodermis_morpholog0.98818474
107MP0002933_joint_inflammation0.98545513
108MP0005365_abnormal_bile_salt0.97410340
109MP0009379_abnormal_foot_pigmentation0.97347492
110MP0001853_heart_inflammation0.96919411
111MP0002398_abnormal_bone_marrow0.96351810
112MP0002429_abnormal_blood_cell0.95363811
113MP0004947_skin_inflammation0.94588099
114MP0002069_abnormal_eating/drinking_beha0.93617017
115MP0000015_abnormal_ear_pigmentation0.93409927
116MP0003866_abnormal_defecation0.91512299
117MP0001545_abnormal_hematopoietic_system0.90848135
118MP0005397_hematopoietic_system_phenotyp0.90848135
119MP0000003_abnormal_adipose_tissue0.90741014
120MP0005584_abnormal_enzyme/coenzyme_acti0.90249067
121MP0005310_abnormal_salivary_gland0.89909110
122MP0003690_abnormal_glial_cell0.89099704
123MP0008875_abnormal_xenobiotic_pharmacok0.88450789
124MP0009840_abnormal_foam_cell0.87243773
125MP0003122_maternal_imprinting0.86592906
126MP0000778_abnormal_nervous_system0.86005198
127MP0004142_abnormal_muscle_tone0.85568756
128MP0003279_aneurysm0.85472370
129MP0005075_abnormal_melanosome_morpholog0.85410672
130MP0001502_abnormal_circadian_rhythm0.85148912
131MP0004085_abnormal_heartbeat0.84745201
132MP0000747_muscle_weakness0.84365786
133MP0000750_abnormal_muscle_regeneration0.82944352
134MP0002405_respiratory_system_inflammati0.82289194
135MP0005257_abnormal_intraocular_pressure0.81993143
136MP0003137_abnormal_impulse_conducting0.81829913
137MP0002078_abnormal_glucose_homeostasis0.81271248
138MP0005390_skeleton_phenotype0.80673995
139MP0002722_abnormal_immune_system0.79422565
140MP0005166_decreased_susceptibility_to0.79261592
141MP0004233_abnormal_muscle_weight0.79217515
142MP0002254_reproductive_system_inflammat0.78947578
143MP0002229_neurodegeneration0.78847036
144MP0001542_abnormal_bone_strength0.77391420
145MP0002118_abnormal_lipid_homeostasis0.77010902
146MP0005332_abnormal_amino_acid0.76467506
147MP0002152_abnormal_brain_morphology0.75896745
148MP0000689_abnormal_spleen_morphology0.75778691
149MP0010234_abnormal_vibrissa_follicle0.75316623
150MP0003634_abnormal_glial_cell0.73250143
151MP0000678_abnormal_parathyroid_gland0.72717542
152MP0001529_abnormal_vocalization0.71556801
153MP0001663_abnormal_digestive_system0.71375467
154MP0000703_abnormal_thymus_morphology0.71362800
155MP0002970_abnormal_white_adipose0.71315040
156MP0002998_abnormal_bone_remodeling0.71301497
157MP0003786_premature_aging0.69367227
158MP0005499_abnormal_olfactory_system0.68884888
159MP0005394_taste/olfaction_phenotype0.68884888
160MP0001984_abnormal_olfaction0.68018326
161MP0002090_abnormal_vision0.67690611
162MP0005646_abnormal_pituitary_gland0.66967708
163MP0001765_abnormal_ion_homeostasis0.64227198
164MP0010386_abnormal_urinary_bladder0.62876050
165MP0006035_abnormal_mitochondrial_morpho0.62606992
166MP0000749_muscle_degeneration0.61336847
167MP0006036_abnormal_mitochondrial_physio0.61046699
168MP0001664_abnormal_digestion0.60012276
169MP0003183_abnormal_peptide_metabolism0.59663557
170MP0004036_abnormal_muscle_relaxation0.59584499
171MP0004215_abnormal_myocardial_fiber0.59483188
172MP0003252_abnormal_bile_duct0.59351647

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.36652985
2Focal motor seizures (HP:0011153)4.87539833
3Abnormality of liposaccharide metabolism (HP:0010968)4.63565734
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.63565734
5Abnormality of glycolipid metabolism (HP:0010969)4.63565734
6Visual hallucinations (HP:0002367)4.57135140
7Focal seizures (HP:0007359)4.26886872
8Dysostosis multiplex (HP:0000943)3.77903756
9Supranuclear gaze palsy (HP:0000605)3.73051753
10Action tremor (HP:0002345)3.61007951
11Increased cerebral lipofuscin (HP:0011813)3.38965877
12Absence seizures (HP:0002121)3.34824749
13Atonic seizures (HP:0010819)3.33359681
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29025722
15Abnormality of polysaccharide metabolism (HP:0011012)3.29025722
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29025722
17Prolonged neonatal jaundice (HP:0006579)3.26561800
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.24537237
19Depression (HP:0000716)3.23851272
20Abnormality of the lower motor neuron (HP:0002366)3.20906247
21Vertebral compression fractures (HP:0002953)3.19069832
22Generalized tonic-clonic seizures (HP:0002069)3.14026521
23Ventricular fibrillation (HP:0001663)3.10615642
24Loss of speech (HP:0002371)3.09150520
25Ankle clonus (HP:0011448)3.08917856
26Papilledema (HP:0001085)3.08449210
27J-shaped sella turcica (HP:0002680)3.06784909
28Febrile seizures (HP:0002373)2.93156541
29Epileptic encephalopathy (HP:0200134)2.91742046
30Bundle branch block (HP:0011710)2.90402628
31Abnormal social behavior (HP:0012433)2.90078009
32Impaired social interactions (HP:0000735)2.90078009
33Progressive cerebellar ataxia (HP:0002073)2.86018739
34Dialeptic seizures (HP:0011146)2.83098271
35Vacuolated lymphocytes (HP:0001922)2.81654497
36Poor eye contact (HP:0000817)2.80297872
37Hypokinesia (HP:0002375)2.75545463
38Torticollis (HP:0000473)2.72184066
39Anxiety (HP:0000739)2.70162547
40Postural instability (HP:0002172)2.67077456
41Pheochromocytoma (HP:0002666)2.67041058
42Impaired vibration sensation in the lower limbs (HP:0002166)2.66823519
43Focal dystonia (HP:0004373)2.66064561
44Hypercortisolism (HP:0001578)2.64927363
45Mutism (HP:0002300)2.60069209
46Cholecystitis (HP:0001082)2.57260917
47Abnormal gallbladder physiology (HP:0012438)2.57260917
48Abnormality of macrophages (HP:0004311)2.57055352
49Hemiplegia (HP:0002301)2.56611162
50Status epilepticus (HP:0002133)2.56156723
51Cerebral inclusion bodies (HP:0100314)2.54240311
52Testicular atrophy (HP:0000029)2.54027834
53Elevated erythrocyte sedimentation rate (HP:0003565)2.53369534
54Joint stiffness (HP:0001387)2.52494259
55Urinary urgency (HP:0000012)2.51873706
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.50085778
57Craniofacial dystonia (HP:0012179)2.49583086
58Dysmetria (HP:0001310)2.48563082
59Dysdiadochokinesis (HP:0002075)2.47179860
60Abnormality of the Achilles tendon (HP:0005109)2.46933321
61Abnormal eating behavior (HP:0100738)2.45342674
62Insomnia (HP:0100785)2.42972979
63Achilles tendon contracture (HP:0001771)2.42097652
64Neurofibrillary tangles (HP:0002185)2.42043331
65Annular pancreas (HP:0001734)2.33024096
66Mediastinal lymphadenopathy (HP:0100721)2.29391081
67Dysmetric saccades (HP:0000641)2.28007365
68Truncal ataxia (HP:0002078)2.27823957
69Rapidly progressive (HP:0003678)2.27524659
70Progressive neurologic deterioration (HP:0002344)2.27308369
71Urinary bladder sphincter dysfunction (HP:0002839)2.26952524
72Neuroendocrine neoplasm (HP:0100634)2.24308420
73Nuclear cataract (HP:0100018)2.23414924
74Intention tremor (HP:0002080)2.22817577
75Hyperacusis (HP:0010780)2.20735110
76Stridor (HP:0010307)2.20625276
77Megalencephaly (HP:0001355)2.20347990
78Failure to thrive in infancy (HP:0001531)2.19144201
79Ocular albinism (HP:0001107)2.18976821
80Bradykinesia (HP:0002067)2.18891399
81Gout (HP:0001997)2.17804899
82Increased IgM level (HP:0003496)2.16451590
83Obstructive lung disease (HP:0006536)2.15649890
84Chronic obstructive pulmonary disease (HP:0006510)2.15649890
85Hepatosplenomegaly (HP:0001433)2.13729807
86Axonal loss (HP:0003447)2.13410083
87Neuronal loss in central nervous system (HP:0002529)2.12863671
88Upper limb amyotrophy (HP:0009129)2.11336581
89Distal upper limb amyotrophy (HP:0007149)2.11336581
90Amyloidosis (HP:0011034)2.10309329
91Scanning speech (HP:0002168)2.05147489
92Myotonia (HP:0002486)2.03112998
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02826672
94Tetraplegia (HP:0002445)2.02541665
95Cervical subluxation (HP:0003308)2.01063635
96Hyperparathyroidism (HP:0000843)2.00798491
97Resting tremor (HP:0002322)2.00134820
98Spastic paraparesis (HP:0002313)1.99779754
99Athetosis (HP:0002305)1.99655168
100Deep venous thrombosis (HP:0002625)1.99622245
101Increased serum ferritin (HP:0003281)1.99049665
102Cerebral aneurysm (HP:0004944)1.98709041
103Agitation (HP:0000713)1.98453859
104Hand muscle atrophy (HP:0009130)1.98289133
105Postural tremor (HP:0002174)1.97690826
106Spastic gait (HP:0002064)1.96929652
107Neoplasm of the peripheral nervous system (HP:0100007)1.96926956
108Cholelithiasis (HP:0001081)1.96464444
109Exercise-induced myalgia (HP:0003738)1.95924198
110Hepatocellular necrosis (HP:0001404)1.95196729
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94964319
112Rigidity (HP:0002063)1.94895050
113Hypertensive crisis (HP:0100735)1.94548772
114Neonatal onset (HP:0003623)1.94366209
115Impaired smooth pursuit (HP:0007772)1.93891347
116Progressive microcephaly (HP:0000253)1.93777302
117Increased muscle lipid content (HP:0009058)1.93289966
118Impaired vibratory sensation (HP:0002495)1.92070417
119Abnormality of cells of the erythroid lineage (HP:0012130)1.91928228
120Abnormal number of erythroid precursors (HP:0012131)1.91734651
121Akinesia (HP:0002304)1.91283143
122Pointed chin (HP:0000307)1.89975328
123Growth hormone excess (HP:0000845)1.89942620
124Global brain atrophy (HP:0002283)1.89875457
125Lower limb asymmetry (HP:0100559)1.89517182
126Progressive inability to walk (HP:0002505)1.88695723
127Paraparesis (HP:0002385)1.87812456
128Apathy (HP:0000741)1.86271453
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86061227
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86061227
131Impaired pain sensation (HP:0007328)1.84785776
132Abnormality of pain sensation (HP:0010832)1.84785776
133Hypoventilation (HP:0002791)1.83777281
134Genetic anticipation (HP:0003743)1.83774608
135Iris hypopigmentation (HP:0007730)1.83553485
136Abnormal EKG (HP:0003115)1.83080263
137Hyperthyroidism (HP:0000836)1.82741001
138Emotional lability (HP:0000712)1.82628849
139Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82627625
140Sudden death (HP:0001699)1.81966637
141Petechiae (HP:0000967)1.81943167
142Peripheral hypomyelination (HP:0007182)1.81825294
143Clonus (HP:0002169)1.81490129
144Obstructive sleep apnea (HP:0002870)1.80271613
145Cellulitis (HP:0100658)1.80196506
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79059780
147Abnormal gallbladder morphology (HP:0012437)1.78783338
148EEG with generalized epileptiform discharges (HP:0011198)1.78063154
149Mucopolysacchariduria (HP:0008155)1.78054447
150Urinary glycosaminoglycan excretion (HP:0003541)1.78054447
151Hemiparesis (HP:0001269)1.77982595
152Delusions (HP:0000746)1.77755214
153Hypsarrhythmia (HP:0002521)1.77649845
154Diplopia (HP:0000651)1.76495848
155Abnormality of binocular vision (HP:0011514)1.76495848
156Ragged-red muscle fibers (HP:0003200)1.76151824
157Epileptiform EEG discharges (HP:0011182)1.75503645
158Heart block (HP:0012722)1.74390099
159Dementia (HP:0000726)1.74090449
160Eczematoid dermatitis (HP:0000976)1.72974023
161Spinal canal stenosis (HP:0003416)1.72865352
162Mesangial abnormality (HP:0001966)1.72229164
163Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.72200962
164Stomatitis (HP:0010280)1.70064291
165Increased intramyocellular lipid droplets (HP:0012240)1.69718090
166Retinal atrophy (HP:0001105)1.67900573
167Dysautonomia (HP:0002459)1.67543179
168Diminished motivation (HP:0000745)1.66346726
169Myopathic facies (HP:0002058)1.65067987
170Flattened epiphyses (HP:0003071)1.65065222
171Myositis (HP:0100614)1.64555900
172Opisthotonus (HP:0002179)1.64519920
173Diminished movement (HP:0002374)1.63720885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.06662668
2TESK23.50941404
3NTRK33.45885983
4NME23.45332347
5DAPK22.97107768
6KSR22.91451688
7EPHA42.82626944
8TESK12.73506746
9PRKD32.67392631
10IRAK32.64758129
11MAP3K42.56862042
12SMG12.45971236
13MAP3K22.42424708
14MINK12.40761655
15NTRK12.38120273
16TRIB32.36421623
17MAP4K12.33805874
18PAK62.25692888
19MAP2K42.15415560
20PIM22.14257238
21VRK22.09548150
22SIK12.07717382
23CAMKK11.97365382
24MARK11.85876211
25MAP2K71.80674850
26TAOK21.79541746
27MAP2K31.70991581
28TBK11.65294572
29DAPK11.57534138
30ARAF1.56708856
31RIPK41.52096205
32MAP3K121.51421576
33GRK51.50898856
34STK381.47939573
35LMTK21.46059195
36PKN21.42633634
37TAOK11.36082043
38NTRK21.34739824
39RET1.33773788
40PRKCH1.31523967
41CDK51.30931106
42PHKG11.29371045
43PHKG21.29371045
44KSR11.27472244
45SIK21.27375977
46UHMK11.18995222
47LATS21.14481636
48SCYL21.14223103
49RIPK11.13937652
50TYRO31.12406284
51BRAF1.11450565
52ALK1.11414564
53MAP3K11.10182749
54SIK31.06046324
55KDR1.05643713
56MAP3K131.05098291
57FES1.04517469
58ERN11.03765685
59PINK11.03435057
60STK111.02114991
61ABL21.01753067
62CDK191.01154512
63NEK11.01100238
64MAP2K61.00992138
65MAP3K30.99803200
66EPHA20.95855615
67DAPK30.95532006
68PRKCG0.91883021
69IRAK40.91212330
70RPS6KA20.91165600
71MAP3K70.91089092
72PTK2B0.88400550
73MAP2K20.87359381
74ZAP700.84866334
75PDPK10.79097037
76TYK20.76928583
77CAMK10.76837088
78PAK30.76021495
79CDK150.75218702
80SGK30.74254680
81CDK140.73543690
82CDK180.72806688
83PDK10.72435494
84EEF2K0.72210113
85HIPK20.72194022
86CAMKK20.71269785
87SGK2230.70587105
88SGK4940.70587105
89MAP2K10.70517845
90PRKCI0.69185846
91PRKCZ0.69180140
92BMX0.69179146
93PDGFRA0.68499790
94PAK40.68345168
95LRRK20.67295459
96MAPK110.66607283
97PLK20.65541947
98CDK11A0.64490215
99IKBKB0.62923530
100DYRK1B0.61662720
101CDC42BPA0.59266416
102ILK0.58556205
103MAPK130.57119409
104MAPKAPK30.57013058
105RAF10.56684854
106TNK20.56042633
107BCKDK0.53588765
108MARK20.53441111
109EPHB10.52458030
110CAMK2A0.52442699
111MAPK120.52215235
112RPS6KC10.50491449
113RPS6KL10.50491449
114JAK20.50112404
115GRK60.49723851
116DDR20.49722803
117AURKA0.49255874
118MAP3K110.48911610
119CAMK40.48706579
120CSNK1G30.46679167
121NME10.46675841
122PRKD20.46508554
123SGK10.46384265
124CSF1R0.46277299
125RPS6KA30.45163294
126MAP3K100.44923053
127MOS0.44835262
128RPS6KA60.43361466
129IKBKE0.41992545
130PTK20.41923473
131TGFBR20.41388922
132FER0.40488314
133WNK40.39477821
134PTK60.38982696
135CAMK2G0.38929949
136PAK10.38777854
137BRSK10.38484165
138MAP3K140.38333288
139PRPF4B0.38201242
140FYN0.38150664
141FGR0.36999445
142ICK0.35806512
143STK160.35515303
144LIMK10.34325529
145WNK10.33912237
146MAPKAPK20.31092795
147TLK10.30716112
148BTK0.28633271
149MAPK40.27249950
150MAP3K80.27210174
151SYK0.27196608

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.77117339
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.81442967
3Synaptic vesicle cycle_Homo sapiens_hsa047213.13650349
4Sulfur relay system_Homo sapiens_hsa041223.03806172
5Lysosome_Homo sapiens_hsa041422.81606176
6Nitrogen metabolism_Homo sapiens_hsa009102.64341086
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47732701
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41584662
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.19863422
10Nicotine addiction_Homo sapiens_hsa050332.19554127
11Olfactory transduction_Homo sapiens_hsa047402.17469605
12Ribosome_Homo sapiens_hsa030102.16461325
13Fructose and mannose metabolism_Homo sapiens_hsa000512.14269982
14GABAergic synapse_Homo sapiens_hsa047272.09605042
15Long-term potentiation_Homo sapiens_hsa047202.09179845
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.98554153
17Circadian entrainment_Homo sapiens_hsa047131.96014681
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.91196740
19Glutamatergic synapse_Homo sapiens_hsa047241.86180213
20Insulin secretion_Homo sapiens_hsa049111.82097184
21* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80414284
22Amphetamine addiction_Homo sapiens_hsa050311.78972356
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77269046
24N-Glycan biosynthesis_Homo sapiens_hsa005101.75429184
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.72643380
26Morphine addiction_Homo sapiens_hsa050321.69720926
27Salivary secretion_Homo sapiens_hsa049701.69675098
28Dopaminergic synapse_Homo sapiens_hsa047281.63452138
29Galactose metabolism_Homo sapiens_hsa000521.63227300
30Gastric acid secretion_Homo sapiens_hsa049711.61135734
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56177234
32Arginine biosynthesis_Homo sapiens_hsa002201.53444964
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50865191
34Cholinergic synapse_Homo sapiens_hsa047251.47316247
35Pentose phosphate pathway_Homo sapiens_hsa000301.44903011
36Primary immunodeficiency_Homo sapiens_hsa053401.42551357
37Oxidative phosphorylation_Homo sapiens_hsa001901.42453490
38Type II diabetes mellitus_Homo sapiens_hsa049301.41067305
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40635124
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39054623
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35766877
42GnRH signaling pathway_Homo sapiens_hsa049121.28302185
43Oxytocin signaling pathway_Homo sapiens_hsa049211.27591802
44Bile secretion_Homo sapiens_hsa049761.24975485
45Rheumatoid arthritis_Homo sapiens_hsa053231.24474890
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24376518
47Osteoclast differentiation_Homo sapiens_hsa043801.21805659
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21056911
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20223989
50Collecting duct acid secretion_Homo sapiens_hsa049661.18139680
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17858939
52Base excision repair_Homo sapiens_hsa034101.17506606
53Renin secretion_Homo sapiens_hsa049241.17386992
54Cocaine addiction_Homo sapiens_hsa050301.15698320
55Glioma_Homo sapiens_hsa052141.15543982
56Allograft rejection_Homo sapiens_hsa053301.15412259
57Acute myeloid leukemia_Homo sapiens_hsa052211.13447577
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12905500
59Gap junction_Homo sapiens_hsa045401.11629553
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10943327
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10073957
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09481457
63Estrogen signaling pathway_Homo sapiens_hsa049151.09285423
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07616304
65Taste transduction_Homo sapiens_hsa047421.07218040
66Notch signaling pathway_Homo sapiens_hsa043301.06472435
67Long-term depression_Homo sapiens_hsa047301.04856155
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02859608
69Primary bile acid biosynthesis_Homo sapiens_hsa001201.02226282
70Tuberculosis_Homo sapiens_hsa051521.02189479
71Cardiac muscle contraction_Homo sapiens_hsa042601.02012056
72Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01241226
73Autoimmune thyroid disease_Homo sapiens_hsa053201.00306869
74B cell receptor signaling pathway_Homo sapiens_hsa046621.00267095
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99144498
76Calcium signaling pathway_Homo sapiens_hsa040200.94157916
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.92652800
78Shigellosis_Homo sapiens_hsa051310.90656018
79Graft-versus-host disease_Homo sapiens_hsa053320.89863522
80Apoptosis_Homo sapiens_hsa042100.87252420
81Type I diabetes mellitus_Homo sapiens_hsa049400.86358405
82Phagosome_Homo sapiens_hsa041450.85881186
83mTOR signaling pathway_Homo sapiens_hsa041500.85761514
84cAMP signaling pathway_Homo sapiens_hsa040240.84986445
85Pyrimidine metabolism_Homo sapiens_hsa002400.84199731
86Leishmaniasis_Homo sapiens_hsa051400.83074417
87Salmonella infection_Homo sapiens_hsa051320.82750033
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82041915
89Vitamin B6 metabolism_Homo sapiens_hsa007500.81183502
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79143112
91Parkinsons disease_Homo sapiens_hsa050120.78957117
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.78639436
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78119853
94Thyroid hormone synthesis_Homo sapiens_hsa049180.78052043
95Serotonergic synapse_Homo sapiens_hsa047260.77509960
96Prion diseases_Homo sapiens_hsa050200.77466198
97Insulin signaling pathway_Homo sapiens_hsa049100.77274471
98VEGF signaling pathway_Homo sapiens_hsa043700.77160567
99Dorso-ventral axis formation_Homo sapiens_hsa043200.77059887
100TNF signaling pathway_Homo sapiens_hsa046680.76321181
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.76205320
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76121648
103Pancreatic secretion_Homo sapiens_hsa049720.75252650
104Epstein-Barr virus infection_Homo sapiens_hsa051690.73970797
105ErbB signaling pathway_Homo sapiens_hsa040120.73178195
106Butanoate metabolism_Homo sapiens_hsa006500.71862907
107Vibrio cholerae infection_Homo sapiens_hsa051100.71461288
108Glucagon signaling pathway_Homo sapiens_hsa049220.71365527
109Sulfur metabolism_Homo sapiens_hsa009200.70555850
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.68978805
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.68174704
112Melanogenesis_Homo sapiens_hsa049160.67297578
113Antigen processing and presentation_Homo sapiens_hsa046120.66715653
114* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66667332
115Alzheimers disease_Homo sapiens_hsa050100.64570663
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.64153361
117Dilated cardiomyopathy_Homo sapiens_hsa054140.63345162
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63148331
119Sphingolipid metabolism_Homo sapiens_hsa006000.62580183
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61819606
121Non-small cell lung cancer_Homo sapiens_hsa052230.60911089
122Regulation of autophagy_Homo sapiens_hsa041400.60817164
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59692141
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.59500264
125Folate biosynthesis_Homo sapiens_hsa007900.59446408
126T cell receptor signaling pathway_Homo sapiens_hsa046600.57903585
127Hepatitis B_Homo sapiens_hsa051610.55850193
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55499941
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55363836
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.55128991
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52724645
132Endocytosis_Homo sapiens_hsa041440.51958224
133Toxoplasmosis_Homo sapiens_hsa051450.50799970
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49767987
135Insulin resistance_Homo sapiens_hsa049310.48570244
136Endometrial cancer_Homo sapiens_hsa052130.48394698
137Pertussis_Homo sapiens_hsa051330.47499040
138Chronic myeloid leukemia_Homo sapiens_hsa052200.47432525
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47010631
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46815891
141Choline metabolism in cancer_Homo sapiens_hsa052310.45239920
142MAPK signaling pathway_Homo sapiens_hsa040100.44602254
143Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44178867
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44155297
145Herpes simplex infection_Homo sapiens_hsa051680.43572079
146Asthma_Homo sapiens_hsa053100.43482044
147Carbon metabolism_Homo sapiens_hsa012000.43237275
148Hepatitis C_Homo sapiens_hsa051600.42110507
149Biosynthesis of amino acids_Homo sapiens_hsa012300.41987104
150PPAR signaling pathway_Homo sapiens_hsa033200.40695617
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40340894
152Influenza A_Homo sapiens_hsa051640.38950551
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38001142
154Fatty acid degradation_Homo sapiens_hsa000710.37835581
155DNA replication_Homo sapiens_hsa030300.37805876
156Prolactin signaling pathway_Homo sapiens_hsa049170.37706144
157Oocyte meiosis_Homo sapiens_hsa041140.36024937
158Axon guidance_Homo sapiens_hsa043600.35792819
159HTLV-I infection_Homo sapiens_hsa051660.35626309
160AMPK signaling pathway_Homo sapiens_hsa041520.34802847
161Proteasome_Homo sapiens_hsa030500.34751796
162Glutathione metabolism_Homo sapiens_hsa004800.34338328
163Measles_Homo sapiens_hsa051620.34204306
164NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34049896
165Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33285339
166Huntingtons disease_Homo sapiens_hsa050160.33227267
167Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33114839
168Bladder cancer_Homo sapiens_hsa052190.32792659
169Rap1 signaling pathway_Homo sapiens_hsa040150.32763596
170Tryptophan metabolism_Homo sapiens_hsa003800.31904718
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.31674859
172Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31259043

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