B3GLCT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. The encoded protein is a type II membrane protein. Defects in this gene are a cause of Peters-plus syndrome (PPS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)4.52063284
2melanin metabolic process (GO:0006582)4.24370803
3glucose 6-phosphate metabolic process (GO:0051156)4.15876042
4secondary metabolite biosynthetic process (GO:0044550)4.03429514
5notochord development (GO:0030903)3.95064264
6dermatan sulfate biosynthetic process (GO:0030208)3.88904121
7wound healing, spreading of epidermal cells (GO:0035313)3.77500249
8sequestering of extracellular ligand from receptor (GO:0035581)3.66053577
9chondrocyte proliferation (GO:0035988)3.58417966
10dermatan sulfate metabolic process (GO:0030205)3.47410859
11regulation of chemokine-mediated signaling pathway (GO:0070099)3.41919529
12resolution of meiotic recombination intermediates (GO:0000712)3.32130361
13establishment of integrated proviral latency (GO:0075713)3.31828006
14nephron tubule formation (GO:0072079)3.31271185
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.27321927
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.23375160
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.21553712
18mesenchymal-epithelial cell signaling (GO:0060638)3.19611508
19ventricular cardiac muscle cell development (GO:0055015)3.18519593
20protein heterotrimerization (GO:0070208)3.16951755
21negative regulation of norepinephrine secretion (GO:0010700)3.11281255
22lateral sprouting from an epithelium (GO:0060601)3.11154271
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10105974
24anterior/posterior axis specification, embryo (GO:0008595)3.09712210
25embryonic skeletal joint morphogenesis (GO:0060272)3.08149984
26mitotic metaphase plate congression (GO:0007080)3.02205737
27pericardium development (GO:0060039)3.00336658
28DNA unwinding involved in DNA replication (GO:0006268)3.00242568
29collagen fibril organization (GO:0030199)2.98294658
30negative regulation of catenin import into nucleus (GO:0035414)2.97343651
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96789750
32protein localization to kinetochore (GO:0034501)2.95489839
33G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.94906902
34chondrocyte development (GO:0002063)2.93989535
35metanephric mesenchyme development (GO:0072075)2.91390028
36outer ear morphogenesis (GO:0042473)2.90558706
37protein localization to cell surface (GO:0034394)2.86349710
38bone trabecula formation (GO:0060346)2.85755735
39mitotic sister chromatid cohesion (GO:0007064)2.85619716
40wound healing, spreading of cells (GO:0044319)2.83877076
41histamine transport (GO:0051608)2.83869239
42lymphangiogenesis (GO:0001946)2.83583282
43meiotic chromosome segregation (GO:0045132)2.83340179
44regulation of cell communication by electrical coupling (GO:0010649)2.83263227
45positive regulation of mitotic sister chromatid separation (GO:1901970)2.82802934
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82802934
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82802934
48kidney mesenchyme development (GO:0072074)2.76205910
49fatty acid elongation (GO:0030497)2.76030302
50intraciliary transport (GO:0042073)2.73302614
51organ induction (GO:0001759)2.70313880
52positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.69455835
53negative regulation of chondrocyte differentiation (GO:0032331)2.66554977
54cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64007222
55DNA damage response, detection of DNA damage (GO:0042769)2.64006459
56righting reflex (GO:0060013)2.63112234
57mitotic cytokinesis (GO:0000281)2.62897854
58cochlea morphogenesis (GO:0090103)2.61984048
59sister chromatid segregation (GO:0000819)2.61691766
60protein heterotetramerization (GO:0051290)2.60451225
61atrial cardiac muscle cell action potential (GO:0086014)2.60379947
62metaphase plate congression (GO:0051310)2.57885368
63regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.55958563
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.55728029
65retina vasculature morphogenesis in camera-type eye (GO:0061299)2.55693491
66kinetochore organization (GO:0051383)2.54729050
67ketone body metabolic process (GO:1902224)2.54022214
68negative regulation of cartilage development (GO:0061037)2.52990705
69intra-S DNA damage checkpoint (GO:0031573)2.52207667
70establishment of chromosome localization (GO:0051303)2.51353992
71mitotic sister chromatid segregation (GO:0000070)2.50968018
72genitalia morphogenesis (GO:0035112)2.49685581
73regulation of RNA export from nucleus (GO:0046831)2.49515421
74cytoskeleton-dependent cytokinesis (GO:0061640)2.49191617
75cartilage morphogenesis (GO:0060536)2.48279211
76lung-associated mesenchyme development (GO:0060484)2.47988712
77fibroblast migration (GO:0010761)2.47648505
78embryonic cranial skeleton morphogenesis (GO:0048701)2.46907762
79establishment of viral latency (GO:0019043)2.46366954
80peptidyl-arginine omega-N-methylation (GO:0035247)2.46286503
81DNA double-strand break processing (GO:0000729)2.45579315
82regulation of cardioblast differentiation (GO:0051890)2.45280076
83convergent extension (GO:0060026)2.44947549
84paraxial mesoderm development (GO:0048339)2.44536578
85C4-dicarboxylate transport (GO:0015740)2.44328351
86regulation of mitotic spindle organization (GO:0060236)2.43190704
87cell migration in hindbrain (GO:0021535)2.42839974
88keratan sulfate catabolic process (GO:0042340)2.42800585
89regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.42624710
90hippo signaling (GO:0035329)2.42213326
91regulation of integrin-mediated signaling pathway (GO:2001044)2.42130150
92chaperone-mediated protein transport (GO:0072321)2.42030064
93regulation of spindle organization (GO:0090224)2.41856124
94sarcomere organization (GO:0045214)2.41571536
95cell adhesion mediated by integrin (GO:0033627)2.41476971
96proximal/distal pattern formation (GO:0009954)2.41265639
97cartilage condensation (GO:0001502)2.40411410
98cell aggregation (GO:0098743)2.40411410
99prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.40156692
100regulation of sister chromatid cohesion (GO:0007063)2.39862625
101calcium-mediated signaling using intracellular calcium source (GO:0035584)2.38827826
102myoblast fusion (GO:0007520)2.37580741
103regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.36850936
104nuclear pore complex assembly (GO:0051292)2.36752141
105vascular smooth muscle contraction (GO:0014829)2.36519782
106middle ear morphogenesis (GO:0042474)2.36418807
107drug transmembrane transport (GO:0006855)2.36225646
108respiratory tube development (GO:0030323)2.35674527
109negative regulation of neurotransmitter transport (GO:0051589)2.34998069
110Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34528021
111kinetochore assembly (GO:0051382)2.31789374
112cullin deneddylation (GO:0010388)2.31727909
113negative regulation of leukocyte chemotaxis (GO:0002689)2.31689266
114regulation of hippo signaling (GO:0035330)2.31319015
115DNA replication checkpoint (GO:0000076)2.31317198
116negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.31301910
117polyketide metabolic process (GO:0030638)2.31204649
118doxorubicin metabolic process (GO:0044598)2.31204649
119daunorubicin metabolic process (GO:0044597)2.31204649
120regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30655664
121regulation of heart morphogenesis (GO:2000826)2.30554347
122nuclear pore organization (GO:0006999)2.30074087
123non-canonical Wnt signaling pathway (GO:0035567)2.29928483
124regulation of establishment of planar polarity (GO:0090175)2.29708491
125pore complex assembly (GO:0046931)2.29610527
126mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.29599925
127positive regulation of smooth muscle cell migration (GO:0014911)2.28972647
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.28533507
129blood vessel maturation (GO:0001955)2.28172873
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.27203079
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.27203079
132isotype switching (GO:0045190)2.27203079
133regulation of cartilage development (GO:0061035)2.25780788
134positive regulation of chromosome segregation (GO:0051984)2.25328523
135glucocorticoid receptor signaling pathway (GO:0042921)2.24505870
136nonmotile primary cilium assembly (GO:0035058)2.24337227
137regulation of actin filament-based movement (GO:1903115)2.23658659
138craniofacial suture morphogenesis (GO:0097094)2.23190128
139regulation of protein heterodimerization activity (GO:0043497)2.22801941
140DNA replication-dependent nucleosome assembly (GO:0006335)2.22643373
141DNA replication-dependent nucleosome organization (GO:0034723)2.22643373
142neuron projection extension involved in neuron projection guidance (GO:1902284)2.22444014
143axon extension involved in axon guidance (GO:0048846)2.22444014
144regulation of chondrocyte differentiation (GO:0032330)2.22193894
145membrane raft organization (GO:0031579)2.21519605
146extracellular fibril organization (GO:0043206)2.21243872
147extracellular regulation of signal transduction (GO:1900115)2.20913766
148extracellular negative regulation of signal transduction (GO:1900116)2.20913766
149regulation of G0 to G1 transition (GO:0070316)2.19544462
150peptidyl-arginine N-methylation (GO:0035246)2.19418308
151peptidyl-arginine methylation (GO:0018216)2.19418308
152Notch signaling involved in heart development (GO:0061314)2.19374293
153histone arginine methylation (GO:0034969)2.18980626
154endocardial cushion morphogenesis (GO:0003203)2.18712250
155negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.18619737
156regulation of telomerase activity (GO:0051972)2.18208565
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.18076510
158epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.17799727
159regulation of cardiac muscle cell contraction (GO:0086004)2.17627293
160chondroitin sulfate catabolic process (GO:0030207)2.17478645
161morphogenesis of an epithelial sheet (GO:0002011)2.16140901
162hair cell differentiation (GO:0035315)2.15176909
163spindle assembly checkpoint (GO:0071173)2.15098004
164endoderm development (GO:0007492)2.14964070
165gastrulation with mouth forming second (GO:0001702)2.14153883
166proline transport (GO:0015824)2.13798439
167positive regulation of endothelial cell differentiation (GO:0045603)2.13430206
168embryonic foregut morphogenesis (GO:0048617)2.12949068
169embryonic forelimb morphogenesis (GO:0035115)2.12573419
170lens fiber cell development (GO:0070307)2.12323946
171negative regulation of BMP signaling pathway (GO:0030514)2.11650001
172limb development (GO:0060173)2.11296013
173negative regulation of dendrite morphogenesis (GO:0050774)2.11177120
174regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.10435940
175DNA strand elongation involved in DNA replication (GO:0006271)2.09849709
176regulation of mitotic sister chromatid segregation (GO:0033047)2.09318606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.86442909
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.88221956
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.47581227
4GBX2_23144817_ChIP-Seq_PC3_Human3.12363239
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.94010442
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92923113
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.87646249
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.76036223
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.70223829
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.61568624
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33661318
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23403469
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21102300
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.20138094
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20093675
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.19596660
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15890147
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.15329192
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07887117
20OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03906896
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.98708743
22AR_21909140_ChIP-Seq_LNCAP_Human1.98260877
23EZH2_22144423_ChIP-Seq_EOC_Human1.97863419
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.93526761
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.92775581
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90016761
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.88327093
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86205850
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86205850
30ELK1_19687146_ChIP-ChIP_HELA_Human1.84954321
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83630682
32TAF15_26573619_Chip-Seq_HEK293_Human1.81078341
33P300_19829295_ChIP-Seq_ESCs_Human1.80974035
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78278569
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77542346
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.76935298
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.76293985
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74862478
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71869106
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70903292
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70427855
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69797493
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67732344
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67319760
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.65366635
46SMAD4_21799915_ChIP-Seq_A2780_Human1.65354520
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.63333022
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63081511
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.62368817
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59133856
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59116361
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58591623
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58024767
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.57865473
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54534262
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.52618179
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51981151
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.51526894
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51500129
60CJUN_26792858_Chip-Seq_BT549_Human1.50652750
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50590953
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.50247069
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46275276
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46156068
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45303704
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44713443
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.43827944
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43124337
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41786727
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39257664
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39257664
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38643536
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37576630
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37116389
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37032591
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36816531
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.36038844
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35960238
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35739729
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.35536837
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.34540221
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34461187
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34001907
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.31227694
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.29354059
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29303771
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28987176
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28953419
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28953419
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28953419
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28357840
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.25979550
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25385127
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25248065
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25188991
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24835108
97STAT3_23295773_ChIP-Seq_U87_Human1.24472507
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24182358
99E2F1_18555785_Chip-Seq_ESCs_Mouse1.24098815
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24011547
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23471923
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22982484
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22577900
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20647611
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20424510
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20403226
107ZNF274_21170338_ChIP-Seq_K562_Hela1.19110639
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18914386
109P53_22387025_ChIP-Seq_ESCs_Mouse1.18669257
110EOMES_21245162_ChIP-Seq_HESCs_Human1.17246442
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17004408
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16248262
113TTF2_22483619_ChIP-Seq_HELA_Human1.16192481
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.13226255
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12509184
116EWS_26573619_Chip-Seq_HEK293_Human1.12507292
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12245710
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.11458107
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10989266
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10631644
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08642278
122SOX2_18555785_Chip-Seq_ESCs_Mouse1.07993042
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07034956
124SOX9_26525672_Chip-Seq_HEART_Mouse1.07006210
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06732733
126RNF2_27304074_Chip-Seq_ESCs_Mouse1.06647110
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.05193140
128TP63_17297297_ChIP-ChIP_HaCaT_Human1.05127996
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.04182073
130NANOG_16153702_ChIP-ChIP_HESCs_Human1.04104107
131CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04052468
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03708442
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03611642
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.03560714
135FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03530072
136STAT3_18555785_Chip-Seq_ESCs_Mouse1.02242847
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01970929
138JUN_21703547_ChIP-Seq_K562_Human1.01541379
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01496027
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01263375
141NFYB_21822215_ChIP-Seq_K562_Human1.00432777
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.99844013
143TBL1_22424771_ChIP-Seq_293T_Human0.99784521
144IGF1R_20145208_ChIP-Seq_DFB_Human0.99690854
145TP53_16413492_ChIP-PET_HCT116_Human0.99298924
146SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99014821
147PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98089831
148FUS_26573619_Chip-Seq_HEK293_Human0.97983926
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97797184
150ISL1_27105846_Chip-Seq_CPCs_Mouse0.97780559
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.97375887
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96103859
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96004645
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95983149
155XRN2_22483619_ChIP-Seq_HELA_Human0.95807687
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95742598
157TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95606584
158POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94998019
159POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94593763
160YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94424282
161ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94017264
162TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93402652
163E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93394496
164TP53_18474530_ChIP-ChIP_U2OS_Human0.93280108
165KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93054287
166AR_21572438_ChIP-Seq_LNCaP_Human0.92857201
167CBX2_27304074_Chip-Seq_ESCs_Mouse0.91775129
168MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90740726
169CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90514252
170CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90186384
171BRD4_25478319_ChIP-Seq_HGPS_Human0.87069915
172TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86518723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.93126330
2MP0003136_yellow_coat_color3.74178708
3MP0005503_abnormal_tendon_morphology3.65493378
4MP0008438_abnormal_cutaneous_collagen3.46407043
5MP0002877_abnormal_melanocyte_morpholog3.17836918
6MP0010030_abnormal_orbit_morphology3.05987476
7MP0005408_hypopigmentation2.94659101
8MP0000015_abnormal_ear_pigmentation2.55843215
9MP0005174_abnormal_tail_pigmentation2.48259319
10MP0010368_abnormal_lymphatic_system2.47168447
11MP0003646_muscle_fatigue2.35854965
12MP0002095_abnormal_skin_pigmentation2.35603149
13MP0009250_abnormal_appendicular_skeleto2.32753200
14MP0000537_abnormal_urethra_morphology2.32347573
15MP0004084_abnormal_cardiac_muscle2.32081338
16MP0002282_abnormal_trachea_morphology2.25023834
17MP0003942_abnormal_urinary_system2.24854533
18MP0005275_abnormal_skin_tensile2.20607673
19MP0003123_paternal_imprinting2.17638618
20MP0000049_abnormal_middle_ear2.15491512
21MP0002102_abnormal_ear_morphology2.12119497
22MP0004272_abnormal_basement_membrane2.06241027
23MP0009053_abnormal_anal_canal2.03111093
24MP0005075_abnormal_melanosome_morpholog2.02942479
25MP0003705_abnormal_hypodermis_morpholog2.01284227
26MP0005248_abnormal_Harderian_gland1.99626303
27MP0000569_abnormal_digit_pigmentation1.93296387
28MP0000371_diluted_coat_color1.92891691
29MP0002249_abnormal_larynx_morphology1.92493466
30MP0003279_aneurysm1.89673517
31MP0002938_white_spotting1.89169055
32MP0003385_abnormal_body_wall1.88891804
33MP0005508_abnormal_skeleton_morphology1.81322578
34MP0001293_anophthalmia1.70402059
35MP0004858_abnormal_nervous_system1.64942716
36MP0002090_abnormal_vision1.63839050
37MP0009379_abnormal_foot_pigmentation1.57394159
38MP0006138_congestive_heart_failure1.57324163
39MP0001324_abnormal_eye_pigmentation1.54443565
40MP0005623_abnormal_meninges_morphology1.53673064
41MP0003121_genomic_imprinting1.52759760
42MP0008932_abnormal_embryonic_tissue1.51201337
43MP0000749_muscle_degeneration1.49318945
44MP0010352_gastrointestinal_tract_polyps1.48778446
45MP0004957_abnormal_blastocyst_morpholog1.48435382
46MP0003755_abnormal_palate_morphology1.48089884
47MP0002932_abnormal_joint_morphology1.46842480
48MP0003937_abnormal_limbs/digits/tail_de1.43639549
49MP0000163_abnormal_cartilage_morphology1.43163699
50MP0003122_maternal_imprinting1.37894368
51MP0002109_abnormal_limb_morphology1.37492013
52MP0005253_abnormal_eye_physiology1.37459014
53MP0001958_emphysema1.36792572
54MP0000428_abnormal_craniofacial_morphol1.36121441
55MP0005257_abnormal_intraocular_pressure1.35387100
56MP0000534_abnormal_ureter_morphology1.34858903
57MP0003950_abnormal_plasma_membrane1.34311770
58MP0004134_abnormal_chest_morphology1.33874447
59MP0001299_abnormal_eye_distance/1.32662709
60MP0002116_abnormal_craniofacial_bone1.32092583
61MP0004484_altered_response_of1.31145912
62MP0004215_abnormal_myocardial_fiber1.30612366
63MP0004036_abnormal_muscle_relaxation1.29849172
64MP0002822_catalepsy1.29751154
65MP0006054_spinal_hemorrhage1.28009357
66MP0003935_abnormal_craniofacial_develop1.26320762
67MP0003806_abnormal_nucleotide_metabolis1.24733441
68MP0003941_abnormal_skin_development1.18877766
69MP0005391_vision/eye_phenotype1.18826630
70MP0000432_abnormal_head_morphology1.18065982
71MP0002075_abnormal_coat/hair_pigmentati1.17501086
72MP0005171_absent_coat_pigmentation1.13822707
73MP0002115_abnormal_skeleton_extremities1.13718097
74MP0001915_intracranial_hemorrhage1.13643248
75MP0003315_abnormal_perineum_morphology1.12187541
76MP0010094_abnormal_chromosome_stability1.10327204
77MP0002108_abnormal_muscle_morphology1.10045668
78MP0002114_abnormal_axial_skeleton1.09749471
79MP0001186_pigmentation_phenotype1.09263035
80MP0000762_abnormal_tongue_morphology1.08951841
81MP0002234_abnormal_pharynx_morphology1.08468136
82MP0003119_abnormal_digestive_system1.08429726
83MP0009384_cardiac_valve_regurgitation1.07194512
84MP0002113_abnormal_skeleton_development1.07114153
85MP0003115_abnormal_respiratory_system1.06342370
86MP0002751_abnormal_autonomic_nervous1.06132769
87MP0003077_abnormal_cell_cycle1.05207014
88MP0003890_abnormal_embryonic-extraembry1.05041805
89MP0005367_renal/urinary_system_phenotyp1.04880870
90MP0000516_abnormal_urinary_system1.04880870
91MP0002233_abnormal_nose_morphology1.04867414
92MP0002089_abnormal_postnatal_growth/wei1.04428467
93MP0002837_dystrophic_cardiac_calcinosis1.03691112
94MP0005167_abnormal_blood-brain_barrier1.03492705
95MP0000566_synostosis1.03212963
96MP0002085_abnormal_embryonic_tissue1.01011739
97MP0001697_abnormal_embryo_size1.00135436
98MP0003938_abnormal_ear_development0.99417309
99MP0002084_abnormal_developmental_patter0.98907913
100MP0004197_abnormal_fetal_growth/weight/0.98874268
101MP0001879_abnormal_lymphatic_vessel0.98725535
102MP0003566_abnormal_cell_adhesion0.98246793
103MP0000751_myopathy0.97849079
104MP0001984_abnormal_olfaction0.95843685
105MP0001270_distended_abdomen0.94179223
106MP0004233_abnormal_muscle_weight0.93696633
107MP0005330_cardiomyopathy0.93441983
108MP0001286_abnormal_eye_development0.92533539
109MP0005197_abnormal_uvea_morphology0.92141458
110MP0003787_abnormal_imprinting0.91917240
111MP0003111_abnormal_nucleus_morphology0.91549781
112MP0002177_abnormal_outer_ear0.91534318
113MP0002896_abnormal_bone_mineralization0.91174467
114MP0004147_increased_porphyrin_level0.91053637
115MP0003283_abnormal_digestive_organ0.89892618
116MP0004381_abnormal_hair_follicle0.88378813
117MP0002697_abnormal_eye_size0.86267769
118MP0000767_abnormal_smooth_muscle0.85745084
119MP0002111_abnormal_tail_morphology0.85297599
120MP0000427_abnormal_hair_cycle0.85099834
121MP0002086_abnormal_extraembryonic_tissu0.84836783
122MP0006072_abnormal_retinal_apoptosis0.84355524
123MP0000350_abnormal_cell_proliferation0.84328060
124MP0005193_abnormal_anterior_eye0.83883542
125MP0003861_abnormal_nervous_system0.83816737
126MP0000733_abnormal_muscle_development0.81983380
127MP0002160_abnormal_reproductive_system0.80905177
128MP0002081_perinatal_lethality0.79813688
129MP0004859_abnormal_synaptic_plasticity0.79793728
130MP0002972_abnormal_cardiac_muscle0.78946574
131MP0001340_abnormal_eyelid_morphology0.78481300
132MP0000747_muscle_weakness0.77499282
133MP0001672_abnormal_embryogenesis/_devel0.77407740
134MP0005380_embryogenesis_phenotype0.77407740
135MP0009780_abnormal_chondrocyte_physiolo0.77213836
136MP0002269_muscular_atrophy0.77038885
137MP0003137_abnormal_impulse_conducting0.76131495
138MP0002092_abnormal_eye_morphology0.75061902
139MP0000462_abnormal_digestive_system0.74462522
140MP0009697_abnormal_copulation0.74326476
141MP0003567_abnormal_fetal_cardiomyocyte0.73493510
142MP0005620_abnormal_muscle_contractility0.73095442
143MP0000778_abnormal_nervous_system0.72388000
144MP0009703_decreased_birth_body0.72268466
145MP0002088_abnormal_embryonic_growth/wei0.72063032
146MP0001346_abnormal_lacrimal_gland0.71893742
147MP0000647_abnormal_sebaceous_gland0.71777862
148MP0003984_embryonic_growth_retardation0.71478044
149MP0004087_abnormal_muscle_fiber0.69380768
150MP0005187_abnormal_penis_morphology0.68216973
151MP0005165_increased_susceptibility_to0.65510333
152MP0002060_abnormal_skin_morphology0.65325771
153MP0002128_abnormal_blood_circulation0.64480885
154MP0001544_abnormal_cardiovascular_syste0.64238229
155MP0005385_cardiovascular_system_phenoty0.64238229

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)4.37121817
2Aplasia/Hypoplasia of the fovea (HP:0008060)4.37121817
3Morphological abnormality of the middle ear (HP:0008609)4.07885332
4Protrusio acetabuli (HP:0003179)3.88200229
5Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.84870884
6Aplasia/Hypoplasia of the macula (HP:0008059)3.75148047
7Bilateral microphthalmos (HP:0007633)3.71093921
8Abnormality of the fovea (HP:0000493)3.69224060
9Aplasia/Hypoplasia of the sternum (HP:0006714)3.47294686
10Aplasia/Hypoplasia affecting the retina (HP:0008061)3.46528957
11Vascular tortuosity (HP:0004948)3.23966351
12Aortic dissection (HP:0002647)3.15357519
13Cutaneous finger syndactyly (HP:0010554)3.13912772
14Bifid tongue (HP:0010297)3.13251763
15Abnormality of the pubic bones (HP:0003172)3.12912902
16Patchy hypopigmentation of hair (HP:0011365)3.10991593
17Arterial tortuosity (HP:0005116)3.10931103
18Hypopigmentation of the fundus (HP:0007894)3.10395844
19White forelock (HP:0002211)3.01989201
20Peripheral hypomyelination (HP:0007182)3.01949106
21Abnormal gallbladder physiology (HP:0012438)2.97156204
22Cholecystitis (HP:0001082)2.97156204
23Cutaneous syndactyly (HP:0012725)2.81431758
24Midline defect of the nose (HP:0004122)2.80826818
25Hypoplasia of the iris (HP:0007676)2.78612114
26Heterochromia iridis (HP:0001100)2.75292825
27Abnormal auditory evoked potentials (HP:0006958)2.72409586
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71976276
29Short 4th metacarpal (HP:0010044)2.71976276
30Neonatal short-limb short stature (HP:0008921)2.71689938
31Down-sloping shoulders (HP:0200021)2.66836130
32Abnormality of the lacrimal duct (HP:0011481)2.61070010
33Abnormal lung lobation (HP:0002101)2.57709536
34Abnormality of the nasolacrimal system (HP:0000614)2.52747585
35Epiphyseal dysplasia (HP:0002656)2.51564637
36Absent eyelashes (HP:0000561)2.50461405
37Cutaneous melanoma (HP:0012056)2.49382639
38Aplasia cutis congenita (HP:0001057)2.48948407
39Ectopic anus (HP:0004397)2.48613135
40Popliteal pterygium (HP:0009756)2.46333213
41Hyporeflexia of lower limbs (HP:0002600)2.45205459
42Premature rupture of membranes (HP:0001788)2.40503013
43Shallow orbits (HP:0000586)2.39039375
44Blue irides (HP:0000635)2.38675454
45Thoracolumbar scoliosis (HP:0002944)2.36950413
46Choanal stenosis (HP:0000452)2.36071620
47Myelomeningocele (HP:0002475)2.34200775
48Short nail (HP:0001799)2.33999497
49Mitral stenosis (HP:0001718)2.33407250
50Ocular albinism (HP:0001107)2.31062107
51Albinism (HP:0001022)2.30932540
52Atrophic scars (HP:0001075)2.29077762
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.28467517
54Osteolytic defects of the hand bones (HP:0009699)2.28467517
55Short tibia (HP:0005736)2.28227469
56Irregular epiphyses (HP:0010582)2.27829619
57Vertebral compression fractures (HP:0002953)2.23955253
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.17805449
59Pterygium (HP:0001059)2.17804119
60Asymmetry of the thorax (HP:0001555)2.17104868
61Atresia of the external auditory canal (HP:0000413)2.15720017
62Unilateral renal agenesis (HP:0000122)2.13297319
63Colon cancer (HP:0003003)2.12825662
64Absent eyebrow (HP:0002223)2.12117422
65Aplasia/Hypoplasia of the fibula (HP:0006492)2.11546856
66Bicornuate uterus (HP:0000813)2.11151637
67Renal hypoplasia (HP:0000089)2.11024351
68Iris hypopigmentation (HP:0007730)2.09801971
69Broad thumb (HP:0011304)2.09564300
70Facial cleft (HP:0002006)2.09509295
71Wide anterior fontanel (HP:0000260)2.09218932
72Chin dimple (HP:0010751)2.08231145
73Anophthalmia (HP:0000528)2.04526844
74Broad long bones (HP:0005622)2.04187533
75Limited hip movement (HP:0008800)2.04060338
76Bladder diverticulum (HP:0000015)2.04032299
77Sensorimotor neuropathy (HP:0007141)2.01877323
78Astrocytoma (HP:0009592)2.00740005
79Abnormality of the astrocytes (HP:0100707)2.00740005
80Ankle contracture (HP:0006466)1.99369169
81Selective tooth agenesis (HP:0001592)1.97931830
82Fused cervical vertebrae (HP:0002949)1.97439367
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.97233751
84Omphalocele (HP:0001539)1.97105974
85Wormian bones (HP:0002645)1.96332319
86Freckling (HP:0001480)1.95980159
87Embryonal renal neoplasm (HP:0011794)1.95109729
88Mesomelia (HP:0003027)1.91852729
89Abnormality of the 4th metacarpal (HP:0010012)1.90721758
90Broad finger (HP:0001500)1.90484353
91Broad phalanx (HP:0006009)1.89290720
92Abnormality of the right ventricle (HP:0001707)1.88429604
93Vitreoretinal degeneration (HP:0000655)1.88287001
94Hepatoblastoma (HP:0002884)1.87162094
95Vertebral hypoplasia (HP:0008417)1.87109389
96Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87109389
97Renal duplication (HP:0000075)1.86167335
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86001327
99Overgrowth (HP:0001548)1.85506967
100Broad phalanges of the hand (HP:0009768)1.84919957
101Infantile muscular hypotonia (HP:0008947)1.84863048
102Lipoatrophy (HP:0100578)1.84582618
103Abnormality of the phalanges of the 5th finger (HP:0004213)1.84378449
104Nemaline bodies (HP:0003798)1.83684567
105Decreased central vision (HP:0007663)1.83164046
106Nephroblastoma (Wilms tumor) (HP:0002667)1.82245934
107Glossoptosis (HP:0000162)1.81708794
108Delayed closure of the anterior fontanelle (HP:0001476)1.81503159
109Abnormality of dentin (HP:0010299)1.81336132
110Mild short stature (HP:0003502)1.81334998
111Calcaneovalgus deformity (HP:0001848)1.80769857
112Broad toe (HP:0001837)1.80681170
113Short 5th finger (HP:0009237)1.80651144
114Short middle phalanx of the 5th finger (HP:0004220)1.79608099
115Tracheomalacia (HP:0002779)1.79548966
116Abnormal hemoglobin (HP:0011902)1.78316815
117Postnatal microcephaly (HP:0005484)1.77957892
118Cervical subluxation (HP:0003308)1.77190852
119Abnormality of the anterior chamber (HP:0000593)1.76546270
120Anterior segment dysgenesis (HP:0007700)1.76383412
121Absent frontal sinuses (HP:0002688)1.76233007
122Aortic aneurysm (HP:0004942)1.75230229
123Spinal cord compression (HP:0002176)1.75158968
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74780572
125Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74657992
126Neoplasm of the peripheral nervous system (HP:0100007)1.73952779
127Soft skin (HP:0000977)1.73530287
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.72973447
129Fibular hypoplasia (HP:0003038)1.72491213
130Deformed tarsal bones (HP:0008119)1.71656938
131Skull defect (HP:0001362)1.70564772
132Follicular hyperkeratosis (HP:0007502)1.70428771
133Delayed cranial suture closure (HP:0000270)1.70143187
134Poor head control (HP:0002421)1.69661463
135Patellar aplasia (HP:0006443)1.69320567
136Microglossia (HP:0000171)1.68184332
137Anteriorly placed anus (HP:0001545)1.67994493
138Atrial fibrillation (HP:0005110)1.66057517
139Camptodactyly of toe (HP:0001836)1.65578172
140Generalized hypopigmentation (HP:0007513)1.65570614
141Genu recurvatum (HP:0002816)1.65494956
142Medulloblastoma (HP:0002885)1.65237467
143Congenital hip dislocation (HP:0001374)1.64762019
144Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.64074433
145Vertebral arch anomaly (HP:0008438)1.63769156
146Bowel diverticulosis (HP:0005222)1.63462731
147Abnormality of the calcaneus (HP:0008364)1.63140255
148Missing ribs (HP:0000921)1.62342667
149Ankyloglossia (HP:0010296)1.61807430
150Hypoplastic pelvis (HP:0008839)1.61352643
151Dilatation of the ascending aorta (HP:0005111)1.61048955
152Delayed gross motor development (HP:0002194)1.60612845
153Volvulus (HP:0002580)1.60265942
154Abnormality of the 2nd finger (HP:0004100)1.59759234
155Pulmonary artery stenosis (HP:0004415)1.59757682
156Sparse lateral eyebrow (HP:0005338)1.59646385
157Occipital encephalocele (HP:0002085)1.59317131
158Increased nuchal translucency (HP:0010880)1.59223342
159Sudden death (HP:0001699)1.59030657
160Spinal rigidity (HP:0003306)1.58488843
161Aplasia/Hypoplasia of the patella (HP:0006498)1.58429517
162Tetraplegia (HP:0002445)1.58300275
163Bundle branch block (HP:0011710)1.58091386
164Abnormal number of incisors (HP:0011064)1.56921031
165Exostoses (HP:0100777)1.56818025
166Broad palm (HP:0001169)1.56627373
167Rib fusion (HP:0000902)1.56354337
168Short hallux (HP:0010109)1.56124018
169Abnormality of the left ventricular outflow tract (HP:0011103)1.56123935
170Subaortic stenosis (HP:0001682)1.56123935
171Decreased skull ossification (HP:0004331)1.56098745
172Conjugated hyperbilirubinemia (HP:0002908)1.55172220
173Biconcave vertebral bodies (HP:0004586)1.54980459
174Exercise-induced muscle cramps (HP:0003710)1.53999959
175Mitral valve prolapse (HP:0001634)1.52633186
176Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.51363644
177Postaxial foot polydactyly (HP:0001830)1.50430619
178Micromelia (HP:0002983)1.47904231
179Median cleft lip (HP:0000161)1.46334213
180Astigmatism (HP:0000483)1.45861625
181Metaphyseal dysplasia (HP:0100255)1.45185139
182Abnormal delivery (HP:0001787)1.45010751
183Hemiparesis (HP:0001269)1.44478100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.51940072
2TLK14.25747182
3DDR23.67061166
4LIMK13.26045741
5MAP4K22.93364700
6TESK12.81090806
7PTK2B2.73783243
8LATS22.72743178
9EIF2AK12.55250801
10CDC72.44751672
11MAP3K122.26227899
12TRIM282.18581354
13TESK22.18161606
14ERBB42.15604225
15BCR2.14345779
16PLK22.07961386
17LMTK22.06027695
18MKNK12.01132863
19PLK41.91091107
20IRAK31.86527162
21WEE11.81285026
22BLK1.76127536
23WNK31.74479575
24NME11.71660416
25TIE11.67252498
26PBK1.64996317
27EPHB21.63103815
28MKNK21.58865606
29MET1.57063199
30GRK51.56797926
31CDK81.54096898
32BRSK21.53963844
33MYLK1.53743766
34ERBB31.51443341
35NEK21.50882685
36PLK31.50531211
37BUB11.49692855
38TTN1.43512548
39CDK191.38753121
40SCYL21.34835314
41TGFBR21.32927072
42EPHA41.30468256
43CSNK1G21.28425662
44MINK11.27059251
45BMPR21.21856424
46CHEK21.18780394
47MAPK131.18722743
48PDGFRA1.17925476
49PLK11.17681454
50PAK61.15799514
51TTK1.11397982
52SIK31.10462415
53UHMK11.10413871
54KSR21.06467584
55MELK1.06340857
56CDK71.06146772
57NEK11.06112511
58MARK11.04936348
59TNIK1.04058478
60EIF2AK31.03610250
61LATS11.03258063
62STK30.98978652
63MAP3K100.96951561
64KDR0.93906201
65NTRK20.91065867
66MATK0.90873851
67KSR10.90278301
68PNCK0.90114993
69FRK0.89762427
70CDK140.89350369
71TGFBR10.89298916
72ERBB20.88804099
73FGFR10.87871826
74PDK20.85770491
75TRIB30.84418491
76PAK40.83905408
77PHKG10.81929459
78PHKG20.81929459
79CDK120.81477955
80ROCK20.77334001
81NEK90.76120689
82CDK11A0.75839074
83CDK180.73763761
84BRSK10.73233786
85PAK20.72962506
86MAP3K20.72482088
87CCNB10.72418833
88NTRK10.71164531
89CAMK2D0.70757392
90CDK150.70310513
91AURKB0.69765590
92CDK60.69321042
93AKT20.68303002
94CAMK2A0.66565971
95SRPK10.63923179
96MOS0.63863322
97ILK0.63090230
98PIK3CA0.63061759
99ADRBK10.62123141
100ACVR1B0.60984807
101OBSCN0.60909284
102PKN20.58434769
103MAPKAPK50.58358665
104RET0.57818230
105CDK20.57276874
106SIK20.55830528
107BMPR1B0.55044908
108RPS6KA40.54928268
109NTRK30.54800489
110ATM0.52589734
111FER0.52404910
112MST1R0.50626200
113PINK10.50331299
114PRKG20.49507098
115EIF2AK20.48700023
116CDK10.47638830
117DYRK20.47301845
118VRK10.45076813
119ROCK10.43585705
120MAP2K10.43163051
121STK240.42962223
122CSNK1A1L0.42952945
123MAP3K80.42413778
124RPS6KB20.42023359
125CSNK1G30.42006919
126CDK30.41404243
127PRKCE0.41083957
128CSNK1D0.40946811
129MAP3K30.40688231
130CLK10.40085897
131CSNK2A10.39971519
132CHEK10.39951012
133STK390.39848963
134STK38L0.39839139
135CAMK2B0.39339054
136AURKA0.39297056
137ATR0.39042709
138MAP3K40.38356675
139DMPK0.38224731
140PRKD30.37980836
141TRPM70.37471924
142MAP2K70.35908259
143IGF1R0.35593340
144CSNK1G10.35589719
145PTK20.34784396
146PTK60.34612442
147PKN10.34535117
148CDC42BPA0.34342961
149CAMK2G0.34245300
150NEK60.33806144

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005246.63804953
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.62435550
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.91266198
4Fatty acid elongation_Homo sapiens_hsa000622.32613482
5Mismatch repair_Homo sapiens_hsa034302.11231415
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03180045
7DNA replication_Homo sapiens_hsa030301.98071514
8Propanoate metabolism_Homo sapiens_hsa006401.95521071
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.84863014
10Basal cell carcinoma_Homo sapiens_hsa052171.83324533
11Protein export_Homo sapiens_hsa030601.82838734
12ECM-receptor interaction_Homo sapiens_hsa045121.77482867
13Ribosome_Homo sapiens_hsa030101.76488265
14Cell cycle_Homo sapiens_hsa041101.75051692
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66103598
16TGF-beta signaling pathway_Homo sapiens_hsa043501.57793539
17Galactose metabolism_Homo sapiens_hsa000521.56050895
18Spliceosome_Homo sapiens_hsa030401.51187321
19Fructose and mannose metabolism_Homo sapiens_hsa000511.49368333
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48612416
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.47745167
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47524402
23Hedgehog signaling pathway_Homo sapiens_hsa043401.40202928
24RNA transport_Homo sapiens_hsa030131.39627397
25Hippo signaling pathway_Homo sapiens_hsa043901.39321947
26Colorectal cancer_Homo sapiens_hsa052101.38233130
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35511084
28Steroid biosynthesis_Homo sapiens_hsa001001.34108374
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33058894
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.32275671
31Protein digestion and absorption_Homo sapiens_hsa049741.29974581
32Oocyte meiosis_Homo sapiens_hsa041141.24418489
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21647727
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20245998
35Base excision repair_Homo sapiens_hsa034101.18706541
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.16079408
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11901478
38Focal adhesion_Homo sapiens_hsa045101.11755673
39Cardiac muscle contraction_Homo sapiens_hsa042601.11750555
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11169467
41Wnt signaling pathway_Homo sapiens_hsa043101.09372014
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08067669
43Non-homologous end-joining_Homo sapiens_hsa034501.06827075
44Pentose phosphate pathway_Homo sapiens_hsa000301.06577965
45MicroRNAs in cancer_Homo sapiens_hsa052061.03080558
46Adherens junction_Homo sapiens_hsa045201.02236457
47HIF-1 signaling pathway_Homo sapiens_hsa040661.02206174
48p53 signaling pathway_Homo sapiens_hsa041151.01512428
49Nucleotide excision repair_Homo sapiens_hsa034201.01175299
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00955200
51Fatty acid metabolism_Homo sapiens_hsa012120.98789755
52Proteoglycans in cancer_Homo sapiens_hsa052050.98461554
53Thyroid cancer_Homo sapiens_hsa052160.98408375
54Melanoma_Homo sapiens_hsa052180.98085318
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95619181
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95588615
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95173136
58Circadian rhythm_Homo sapiens_hsa047100.94240687
59Sphingolipid metabolism_Homo sapiens_hsa006000.93950221
60Melanogenesis_Homo sapiens_hsa049160.93186576
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93028933
62Carbon metabolism_Homo sapiens_hsa012000.92428004
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91024493
64One carbon pool by folate_Homo sapiens_hsa006700.90744743
65Lysine degradation_Homo sapiens_hsa003100.89860758
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89632963
67Fanconi anemia pathway_Homo sapiens_hsa034600.86477755
68Parkinsons disease_Homo sapiens_hsa050120.85846195
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85409252
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85027942
71Homologous recombination_Homo sapiens_hsa034400.84523664
72Glioma_Homo sapiens_hsa052140.83746884
73Endometrial cancer_Homo sapiens_hsa052130.83154413
74Axon guidance_Homo sapiens_hsa043600.81886624
75Bladder cancer_Homo sapiens_hsa052190.81778922
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79719446
77Pathways in cancer_Homo sapiens_hsa052000.79510779
78Small cell lung cancer_Homo sapiens_hsa052220.77261354
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75845879
80Viral myocarditis_Homo sapiens_hsa054160.75134054
81Pyruvate metabolism_Homo sapiens_hsa006200.74798532
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74761202
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73806069
84Proteasome_Homo sapiens_hsa030500.73420026
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72824951
86Chronic myeloid leukemia_Homo sapiens_hsa052200.71238596
87Gap junction_Homo sapiens_hsa045400.70879602
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70086072
89Biosynthesis of amino acids_Homo sapiens_hsa012300.69678626
90RNA degradation_Homo sapiens_hsa030180.67668988
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67626846
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66849390
93Butanoate metabolism_Homo sapiens_hsa006500.66387010
94Rap1 signaling pathway_Homo sapiens_hsa040150.66359359
95Pyrimidine metabolism_Homo sapiens_hsa002400.66321619
96Dilated cardiomyopathy_Homo sapiens_hsa054140.65534128
97mRNA surveillance pathway_Homo sapiens_hsa030150.64799706
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64708548
99Renin-angiotensin system_Homo sapiens_hsa046140.64539183
100Long-term depression_Homo sapiens_hsa047300.64266491
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64131901
102N-Glycan biosynthesis_Homo sapiens_hsa005100.63699678
103Huntingtons disease_Homo sapiens_hsa050160.63222112
104Gastric acid secretion_Homo sapiens_hsa049710.63130082
105Type II diabetes mellitus_Homo sapiens_hsa049300.62161394
106Platelet activation_Homo sapiens_hsa046110.61821734
107mTOR signaling pathway_Homo sapiens_hsa041500.61461078
108Olfactory transduction_Homo sapiens_hsa047400.61146139
109Glutathione metabolism_Homo sapiens_hsa004800.60173545
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59751978
111HTLV-I infection_Homo sapiens_hsa051660.57832369
112Alzheimers disease_Homo sapiens_hsa050100.57324965
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57239903
114Insulin signaling pathway_Homo sapiens_hsa049100.55014210
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54473432
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52715786
117Nicotine addiction_Homo sapiens_hsa050330.52325825
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.51902232
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.51717693
120Basal transcription factors_Homo sapiens_hsa030220.51600704
121Dorso-ventral axis formation_Homo sapiens_hsa043200.51569520
122Prostate cancer_Homo sapiens_hsa052150.51078891
123Mineral absorption_Homo sapiens_hsa049780.50770200
124Salivary secretion_Homo sapiens_hsa049700.49916975
125RNA polymerase_Homo sapiens_hsa030200.49807548
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48814327
127GnRH signaling pathway_Homo sapiens_hsa049120.48734220
128Thyroid hormone synthesis_Homo sapiens_hsa049180.48436807
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48408728
130Tight junction_Homo sapiens_hsa045300.48362029
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48131829
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47418668
133Long-term potentiation_Homo sapiens_hsa047200.46419151
134Fatty acid biosynthesis_Homo sapiens_hsa000610.46408581
135Oxidative phosphorylation_Homo sapiens_hsa001900.45529455
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45145056
137VEGF signaling pathway_Homo sapiens_hsa043700.44919890
138Fatty acid degradation_Homo sapiens_hsa000710.44135778
139ErbB signaling pathway_Homo sapiens_hsa040120.42906641
140Calcium signaling pathway_Homo sapiens_hsa040200.39266254
141Tyrosine metabolism_Homo sapiens_hsa003500.37376682
142Arginine and proline metabolism_Homo sapiens_hsa003300.37279430
143Peroxisome_Homo sapiens_hsa041460.36290892
144PPAR signaling pathway_Homo sapiens_hsa033200.36191211

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