B3GNT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase protein family. The encoded enzyme is involved in the biosynthesis of poly-N-acetyllactosamine chains and prefers lacto-N-neotetraose as a substrate. It is a type II transmembrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.70885350
2axon ensheathment in central nervous system (GO:0032291)6.70885350
3axonemal dynein complex assembly (GO:0070286)5.62073650
4epithelial cilium movement (GO:0003351)5.58651898
5cilium movement (GO:0003341)5.51941270
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.22893617
7piRNA metabolic process (GO:0034587)5.13909431
8centriole replication (GO:0007099)5.00037279
9water-soluble vitamin biosynthetic process (GO:0042364)4.73011336
10male meiosis (GO:0007140)4.55564003
11chaperone-mediated protein transport (GO:0072321)4.52490076
12rRNA methylation (GO:0031167)4.37343899
13regulation of meiosis (GO:0040020)4.35279572
14rRNA modification (GO:0000154)4.34061271
15cornea development in camera-type eye (GO:0061303)4.29809136
16meiotic cell cycle (GO:0051321)4.22162875
17DNA damage induced protein phosphorylation (GO:0006975)4.20256028
18GTP biosynthetic process (GO:0006183)4.10653861
19behavioral response to nicotine (GO:0035095)3.98835598
20cellular response to ATP (GO:0071318)3.96610273
21meiotic chromosome segregation (GO:0045132)3.95430349
22proteasome assembly (GO:0043248)3.88646236
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82942838
24axoneme assembly (GO:0035082)3.78601939
25negative regulation of execution phase of apoptosis (GO:1900118)3.73793425
26glycerophospholipid catabolic process (GO:0046475)3.71572054
27protein complex biogenesis (GO:0070271)3.70409909
28male meiosis I (GO:0007141)3.70341863
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69689300
30regulation of meiosis I (GO:0060631)3.68839395
31centriole assembly (GO:0098534)3.66665745
32DNA methylation involved in gamete generation (GO:0043046)3.63843023
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.61786747
34regulation of meiotic cell cycle (GO:0051445)3.61159323
35synaptonemal complex organization (GO:0070193)3.60588472
36mitotic metaphase plate congression (GO:0007080)3.57686710
37base-excision repair, AP site formation (GO:0006285)3.56699163
38microtubule polymerization or depolymerization (GO:0031109)3.54409375
39microtubule severing (GO:0051013)3.53476600
40regulation of female gonad development (GO:2000194)3.52648610
41mitochondrial respiratory chain complex assembly (GO:0033108)3.49906084
42regulation of exit from mitosis (GO:0007096)3.48861143
43nucleoside diphosphate phosphorylation (GO:0006165)3.47679654
44cilium or flagellum-dependent cell motility (GO:0001539)3.45388847
45UTP biosynthetic process (GO:0006228)3.44005816
46eye photoreceptor cell differentiation (GO:0001754)3.43698195
47photoreceptor cell differentiation (GO:0046530)3.43698195
48energy coupled proton transport, down electrochemical gradient (GO:0015985)3.39772732
49ATP synthesis coupled proton transport (GO:0015986)3.39772732
50positive regulation of meiosis (GO:0045836)3.37779152
51protein neddylation (GO:0045116)3.36675221
52long-chain fatty acid biosynthetic process (GO:0042759)3.36260622
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36104004
54regulation of mitochondrial translation (GO:0070129)3.35916933
55regulation of double-strand break repair via homologous recombination (GO:0010569)3.35020519
56pseudouridine synthesis (GO:0001522)3.30868076
57female gamete generation (GO:0007292)3.28809581
58multicellular organism reproduction (GO:0032504)3.28423346
59synaptonemal complex assembly (GO:0007130)3.27689851
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.26041783
61positive regulation of meiotic cell cycle (GO:0051446)3.24320701
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.22695896
63NADH dehydrogenase complex assembly (GO:0010257)3.22695896
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22695896
65meiosis I (GO:0007127)3.21688921
66regulation of acrosome reaction (GO:0060046)3.17366436
67maturation of 5.8S rRNA (GO:0000460)3.15403492
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.15400887
69pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13528769
70electron transport chain (GO:0022900)3.13131137
71DNA deamination (GO:0045006)3.12486448
72cilium morphogenesis (GO:0060271)3.11284398
73negative regulation of meiosis (GO:0045835)3.11183248
74respiratory chain complex IV assembly (GO:0008535)3.10699219
75metaphase plate congression (GO:0051310)3.09231274
76respiratory electron transport chain (GO:0022904)3.08825683
77cytochrome complex assembly (GO:0017004)3.05500683
78resolution of meiotic recombination intermediates (GO:0000712)3.02707053
79photoreceptor cell development (GO:0042461)3.01689960
80nucleotide transmembrane transport (GO:1901679)3.00002439
81organ growth (GO:0035265)2.99542547
82DNA replication checkpoint (GO:0000076)2.99046448
83histone H2A ubiquitination (GO:0033522)2.97997918
84exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97366618
85myelination (GO:0042552)2.96623199
86keratinocyte development (GO:0003334)2.96153761
87female gonad development (GO:0008585)2.95746693
88nonmotile primary cilium assembly (GO:0035058)2.93753495
89ensheathment of neurons (GO:0007272)2.93466706
90axon ensheathment (GO:0008366)2.93466706
91protein polyglutamylation (GO:0018095)2.92018157
92regulation of glucokinase activity (GO:0033131)2.90233469
93regulation of hexokinase activity (GO:1903299)2.90233469
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89598942
95UTP metabolic process (GO:0046051)2.88218725
96negative regulation of DNA-templated transcription, elongation (GO:0032785)2.86973391
97negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.86973391
98protein-cofactor linkage (GO:0018065)2.86859649
99regulation of DNA methylation (GO:0044030)2.86653698
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.86595583
101termination of RNA polymerase III transcription (GO:0006386)2.86595583
102dopamine biosynthetic process (GO:0042416)2.86566630
103preassembly of GPI anchor in ER membrane (GO:0016254)2.86286566
104tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85553395
105RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85553395
106replication fork processing (GO:0031297)2.85260730
107regulation of histone H3-K27 methylation (GO:0061085)2.84551883
108protein K6-linked ubiquitination (GO:0085020)2.84532082
109single fertilization (GO:0007338)2.83694123
110positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.83439046
111detection of light stimulus involved in visual perception (GO:0050908)2.82993760
112detection of light stimulus involved in sensory perception (GO:0050962)2.82993760
113regulation of mitotic spindle checkpoint (GO:1903504)2.82297892
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82297892
115positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.82292217
116mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.82292217
117otic vesicle formation (GO:0030916)2.82227758
118tRNA processing (GO:0008033)2.82026042
119retinal cone cell development (GO:0046549)2.81532452
120RNA destabilization (GO:0050779)2.81377167
121deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.80843863
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80773026
123DNA damage response, signal transduction resulting in transcription (GO:0042772)2.80676321
124mannosylation (GO:0097502)2.79473496
125meiotic nuclear division (GO:0007126)2.79341759
126fertilization (GO:0009566)2.78190065
127negative regulation of meiotic cell cycle (GO:0051447)2.75770008
128CTP metabolic process (GO:0046036)2.75232769
129CTP biosynthetic process (GO:0006241)2.75232769
130eye photoreceptor cell development (GO:0042462)2.74487062
131intraciliary transport (GO:0042073)2.74378429
132cullin deneddylation (GO:0010388)2.74137223
133fusion of sperm to egg plasma membrane (GO:0007342)2.73597309
134DNA double-strand break processing (GO:0000729)2.71861414
135regulation of inclusion body assembly (GO:0090083)2.70979300
136histone exchange (GO:0043486)2.70475254
137CENP-A containing nucleosome assembly (GO:0034080)2.69637033
138motile cilium assembly (GO:0044458)2.67855215
139chromatin remodeling at centromere (GO:0031055)2.66594297
140cilium organization (GO:0044782)2.63182824
141DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.61652948
1427-methylguanosine mRNA capping (GO:0006370)2.61463566
143cilium assembly (GO:0042384)2.61037249
144reproduction (GO:0000003)2.60557769
145regulation of female receptivity (GO:0045924)2.59755665
146histone H2B ubiquitination (GO:0033523)2.57814268
147protein deneddylation (GO:0000338)2.57383255
148recombinational repair (GO:0000725)2.57172208
149reciprocal DNA recombination (GO:0035825)2.56955428
150reciprocal meiotic recombination (GO:0007131)2.56955428
151regulation of cilium movement (GO:0003352)2.56714335
152double-strand break repair via homologous recombination (GO:0000724)2.56240967
153protein localization to cilium (GO:0061512)2.56088437
154guanosine-containing compound biosynthetic process (GO:1901070)2.55992573
155transcription elongation from RNA polymerase I promoter (GO:0006362)2.55840711
156protein K11-linked ubiquitination (GO:0070979)2.55270947
157amino acid salvage (GO:0043102)2.54816962
158L-methionine salvage (GO:0071267)2.54816962
159L-methionine biosynthetic process (GO:0071265)2.54816962
160spinal cord motor neuron differentiation (GO:0021522)2.54328184
161negative regulation of neurotransmitter transport (GO:0051589)2.54039050
162regulation of calcium ion-dependent exocytosis (GO:0017158)2.53324261
163regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.52818450
1647-methylguanosine RNA capping (GO:0009452)2.52056045
165vitamin biosynthetic process (GO:0009110)2.50725179
166negative regulation of DNA-dependent DNA replication (GO:2000104)2.47430715
167peptidyl-histidine modification (GO:0018202)2.47069005
168tRNA modification (GO:0006400)2.42839550
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42429379
170cellular ketone body metabolic process (GO:0046950)2.42389601
171negative regulation of cell aging (GO:0090344)2.42007190
172tRNA metabolic process (GO:0006399)2.41313334
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39018306
174dopamine transport (GO:0015872)2.35499420
175synapsis (GO:0007129)2.33543667
176purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.33512605
1773-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.33512605
178L-fucose catabolic process (GO:0042355)2.33476232
179fucose catabolic process (GO:0019317)2.33476232
180L-fucose metabolic process (GO:0042354)2.33476232
181hydrogen ion transmembrane transport (GO:1902600)2.30994109
182inositol phosphate catabolic process (GO:0071545)2.29596558
183phosphorylated carbohydrate dephosphorylation (GO:0046838)2.29518069
184inositol phosphate dephosphorylation (GO:0046855)2.29518069
185DNA catabolic process, exonucleolytic (GO:0000738)2.28064870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.58845611
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.35295307
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.45318210
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95438520
5ZNF274_21170338_ChIP-Seq_K562_Hela2.88087145
6EZH2_22144423_ChIP-Seq_EOC_Human2.76514598
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.75711421
8GATA1_26923725_Chip-Seq_HPCs_Mouse2.55579774
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.52005913
10VDR_22108803_ChIP-Seq_LS180_Human2.43390346
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42696785
12EWS_26573619_Chip-Seq_HEK293_Human2.37589494
13GBX2_23144817_ChIP-Seq_PC3_Human2.30197032
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22463166
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20392937
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18994895
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13183405
18VDR_23849224_ChIP-Seq_CD4+_Human2.12359727
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.10861835
20* KAP1_22055183_ChIP-Seq_ESCs_Mouse2.09506152
21RNF2_27304074_Chip-Seq_NSC_Mouse1.95655198
22TAF15_26573619_Chip-Seq_HEK293_Human1.80926376
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78292329
24IGF1R_20145208_ChIP-Seq_DFB_Human1.77876920
25TP53_22573176_ChIP-Seq_HFKS_Human1.77798292
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76198456
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.74141082
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73171302
29ELK1_19687146_ChIP-ChIP_HELA_Human1.72856663
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.69726100
31FUS_26573619_Chip-Seq_HEK293_Human1.67439804
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65541195
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.62760789
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61632911
35FOXP3_21729870_ChIP-Seq_TREG_Human1.59446360
36LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58793449
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58642020
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57825797
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54472026
40IRF1_19129219_ChIP-ChIP_H3396_Human1.53684378
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53066673
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49739244
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49163341
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48215143
45NANOG_18555785_Chip-Seq_ESCs_Mouse1.47764915
46MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45345186
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44924943
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44821009
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.44574812
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44274134
51CBP_20019798_ChIP-Seq_JUKART_Human1.42546511
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42546511
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37612413
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37527368
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35467285
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34109538
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30633661
58MYC_18940864_ChIP-ChIP_HL60_Human1.27468657
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26692060
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26437859
61DCP1A_22483619_ChIP-Seq_HELA_Human1.25672892
62EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25236639
63ER_23166858_ChIP-Seq_MCF-7_Human1.23732371
64P300_18555785_Chip-Seq_ESCs_Mouse1.23696678
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22543126
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.21843648
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21397483
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21003866
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20753371
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20747335
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20648725
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.20474765
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.19380695
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19278925
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.19228510
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18965036
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18965036
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18875308
79REST_21632747_ChIP-Seq_MESCs_Mouse1.18099184
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.17453458
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.16709521
82NCOR_22424771_ChIP-Seq_293T_Human1.16075547
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.15634787
84AR_21572438_ChIP-Seq_LNCaP_Human1.14800867
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14319179
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.14319179
87CMYC_18555785_Chip-Seq_ESCs_Mouse1.13900844
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.13322456
89SOX2_19829295_ChIP-Seq_ESCs_Human1.12869128
90NANOG_19829295_ChIP-Seq_ESCs_Human1.12869128
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.12598188
92P53_22387025_ChIP-Seq_ESCs_Mouse1.12581947
93* TTF2_22483619_ChIP-Seq_HELA_Human1.12450148
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12058619
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11888885
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11749269
97BCAT_22108803_ChIP-Seq_LS180_Human1.10531072
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.09933718
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.08268296
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07696100
101GABP_19822575_ChIP-Seq_HepG2_Human1.07009890
102ZFX_18555785_Chip-Seq_ESCs_Mouse1.06401319
103HTT_18923047_ChIP-ChIP_STHdh_Human1.06359766
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05414364
105SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04672496
106POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04166074
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04094735
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03789795
109JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03358921
110NMYC_18555785_Chip-Seq_ESCs_Mouse1.02609354
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01848369
112EZH2_27304074_Chip-Seq_ESCs_Mouse1.01845654
113HOXB7_26014856_ChIP-Seq_BT474_Human1.01668339
114RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01465556
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00853476
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00521536
117XRN2_22483619_ChIP-Seq_HELA_Human1.00204488
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.00203939
119JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99601584
120AR_25329375_ChIP-Seq_VCAP_Human0.99178841
121OCT4_18555785_Chip-Seq_ESCs_Mouse0.99066992
122P300_19829295_ChIP-Seq_ESCs_Human0.98767719
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98613545
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98002482
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97811756
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97527391
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97394901
128STAT3_23295773_ChIP-Seq_U87_Human0.97230042
129ERA_21632823_ChIP-Seq_H3396_Human0.96901039
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96452031
131MYC_19829295_ChIP-Seq_ESCs_Human0.96208160
132AR_20517297_ChIP-Seq_VCAP_Human0.96173848
133ETS1_20019798_ChIP-Seq_JURKAT_Human0.96141894
134SMAD4_21799915_ChIP-Seq_A2780_Human0.95711428
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93620518
136CTCF_18555785_Chip-Seq_ESCs_Mouse0.93446787
137FOXM1_23109430_ChIP-Seq_U2OS_Human0.93066539
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92789983
139CRX_20693478_ChIP-Seq_RETINA_Mouse0.91499264
140TCF4_22108803_ChIP-Seq_LS180_Human0.91481845
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91116762
142LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90774091
143ERG_20517297_ChIP-Seq_VCAP_Human0.90423512
144STAT1_20625510_ChIP-Seq_HELA_Human0.90184476
145TBL1_22424771_ChIP-Seq_293T_Human0.90011352
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89796388
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89462165
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89008787
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.88617999
150TCF4_23295773_ChIP-Seq_U87_Human0.88162647
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.87715873
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87693549
153RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86962817
154RUNX2_22187159_ChIP-Seq_PCA_Human0.86925547
155NANOG_20526341_ChIP-Seq_ESCs_Human0.86877730
156STAT1_17558387_ChIP-Seq_HELA_Human0.86226662
157* GATA3_21867929_ChIP-Seq_TH1_Mouse0.86174996
158CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85483574
159GF1B_26923725_Chip-Seq_HPCs_Mouse0.84736545
160SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84659029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.17975889
2MP0005451_abnormal_body_composition3.94001734
3MP0003718_maternal_effect3.71134967
4MP0003136_yellow_coat_color3.46924182
5MP0002102_abnormal_ear_morphology3.38029692
6MP0008877_abnormal_DNA_methylation3.23962929
7MP0001905_abnormal_dopamine_level2.99495166
8MP0001986_abnormal_taste_sensitivity2.91623641
9MP0001968_abnormal_touch/_nociception2.51769334
10MP0001529_abnormal_vocalization2.51324064
11MP0003646_muscle_fatigue2.27986815
12MP0000372_irregular_coat_pigmentation2.27004588
13MP0001485_abnormal_pinna_reflex2.23212514
14MP0005174_abnormal_tail_pigmentation2.22570345
15MP0005410_abnormal_fertilization2.22363405
16MP0008260_abnormal_autophagy2.13374502
17MP0003937_abnormal_limbs/digits/tail_de2.11114442
18MP0005171_absent_coat_pigmentation2.03062661
19MP0001929_abnormal_gametogenesis2.02562419
20MP0003693_abnormal_embryo_hatching2.01609761
21MP0004270_analgesia2.01314299
22MP0002736_abnormal_nociception_after2.00875021
23MP0006292_abnormal_olfactory_placode2.00256476
24MP0003880_abnormal_central_pattern1.98308740
25MP0003787_abnormal_imprinting1.92997654
26MP0003195_calcinosis1.83190487
27MP0003315_abnormal_perineum_morphology1.82384003
28MP0008932_abnormal_embryonic_tissue1.81311184
29MP0004742_abnormal_vestibular_system1.80454224
30MP0008789_abnormal_olfactory_epithelium1.74765244
31MP0002210_abnormal_sex_determination1.71536648
32MP0006072_abnormal_retinal_apoptosis1.61957961
33MP0009745_abnormal_behavioral_response1.60158059
34MP0005646_abnormal_pituitary_gland1.59639678
35MP0003698_abnormal_male_reproductive1.59573353
36MP0000653_abnormal_sex_gland1.57218677
37MP0009046_muscle_twitch1.56678866
38MP0008875_abnormal_xenobiotic_pharmacok1.56276189
39MP0000566_synostosis1.54965761
40MP0000778_abnormal_nervous_system1.54930930
41MP0004147_increased_porphyrin_level1.54392693
42MP0002249_abnormal_larynx_morphology1.52120920
43MP0009250_abnormal_appendicular_skeleto1.47860073
44MP0001486_abnormal_startle_reflex1.47760472
45MP0006276_abnormal_autonomic_nervous1.46420645
46MP0005395_other_phenotype1.43985764
47MP0002638_abnormal_pupillary_reflex1.42769102
48MP0000462_abnormal_digestive_system1.42630414
49MP0002735_abnormal_chemical_nociception1.37840229
50MP0002734_abnormal_mechanical_nocicepti1.37436361
51MP0003329_amyloid_beta_deposits1.36063381
52MP0004133_heterotaxia1.33566533
53MP0008872_abnormal_physiological_respon1.32447158
54MP0001984_abnormal_olfaction1.29769821
55MP0005499_abnormal_olfactory_system1.28895821
56MP0005394_taste/olfaction_phenotype1.28895821
57MP0001145_abnormal_male_reproductive1.27439835
58MP0002876_abnormal_thyroid_physiology1.27025318
59MP0002161_abnormal_fertility/fecundity1.26778205
60MP0003121_genomic_imprinting1.26199702
61MP0005389_reproductive_system_phenotype1.26157150
62MP0004043_abnormal_pH_regulation1.25616894
63MP0003938_abnormal_ear_development1.24787400
64MP0002177_abnormal_outer_ear1.24456530
65MP0003699_abnormal_female_reproductive1.23859250
66MP0000427_abnormal_hair_cycle1.22263782
67MP0002752_abnormal_somatic_nervous1.21309539
68MP0000049_abnormal_middle_ear1.20219437
69MP0005084_abnormal_gallbladder_morpholo1.18017538
70MP0005408_hypopigmentation1.16941409
71MP0000631_abnormal_neuroendocrine_gland1.16195888
72MP0003111_abnormal_nucleus_morphology1.15097167
73MP0003786_premature_aging1.15085965
74MP0004381_abnormal_hair_follicle1.14735421
75MP0009780_abnormal_chondrocyte_physiolo1.14256576
76MP0005253_abnormal_eye_physiology1.13579032
77MP0002233_abnormal_nose_morphology1.13463443
78MP0000920_abnormal_myelination1.13366701
79MP0001119_abnormal_female_reproductive1.13289374
80MP0002909_abnormal_adrenal_gland1.13038707
81MP0002837_dystrophic_cardiac_calcinosis1.12552986
82MP0002064_seizures1.12413427
83MP0001919_abnormal_reproductive_system1.11955864
84MP0002163_abnormal_gland_morphology1.11094617
85MP0002272_abnormal_nervous_system1.10065639
86MP0008995_early_reproductive_senescence1.09878619
87MP0002572_abnormal_emotion/affect_behav1.09869564
88MP0005551_abnormal_eye_electrophysiolog1.09804743
89MP0003861_abnormal_nervous_system1.09703488
90MP0004957_abnormal_blastocyst_morpholog1.08679451
91MP0008058_abnormal_DNA_repair1.08366697
92MP0000026_abnormal_inner_ear1.08013939
93MP0005645_abnormal_hypothalamus_physiol1.06189225
94MP0001502_abnormal_circadian_rhythm1.05823248
95MP0001963_abnormal_hearing_physiology1.05070113
96MP0003077_abnormal_cell_cycle1.05036266
97MP0002751_abnormal_autonomic_nervous1.04473588
98MP0005379_endocrine/exocrine_gland_phen1.03820890
99MP0001944_abnormal_pancreas_morphology1.03799510
100MP0003635_abnormal_synaptic_transmissio1.02344734
101MP0003806_abnormal_nucleotide_metabolis0.99120968
102MP0005332_abnormal_amino_acid0.98616612
103MP0003950_abnormal_plasma_membrane0.98347777
104MP0003755_abnormal_palate_morphology0.98288814
105MP0006036_abnormal_mitochondrial_physio0.98086988
106MP0002160_abnormal_reproductive_system0.96272963
107MP0001324_abnormal_eye_pigmentation0.94989467
108MP0004885_abnormal_endolymph0.94556241
109MP0003890_abnormal_embryonic-extraembry0.93499683
110MP0001756_abnormal_urination0.93493973
111MP0005409_darkened_coat_color0.92273384
112MP0001188_hyperpigmentation0.91916447
113MP0002882_abnormal_neuron_morphology0.91383149
114MP0010386_abnormal_urinary_bladder0.90950046
115MP0010094_abnormal_chromosome_stability0.90931881
116MP0000613_abnormal_salivary_gland0.90010415
117MP0000579_abnormal_nail_morphology0.89532945
118MP0002557_abnormal_social/conspecific_i0.89367254
119MP0005310_abnormal_salivary_gland0.87789614
120MP0002063_abnormal_learning/memory/cond0.87390661
121MP0000647_abnormal_sebaceous_gland0.86623780
122MP0003690_abnormal_glial_cell0.86250232
123MP0005257_abnormal_intraocular_pressure0.85996279
124MP0005423_abnormal_somatic_nervous0.85554277
125MP0008007_abnormal_cellular_replicative0.84633051
126MP0004142_abnormal_muscle_tone0.84253996
127MP0001970_abnormal_pain_threshold0.84127462
128MP0001340_abnormal_eyelid_morphology0.84068920
129MP0003011_delayed_dark_adaptation0.83136309
130MP0002928_abnormal_bile_duct0.82750527
131MP0003119_abnormal_digestive_system0.82726693
132MP0002067_abnormal_sensory_capabilities0.82156542
133MP0008057_abnormal_DNA_replication0.81906097
134MP0002095_abnormal_skin_pigmentation0.81841631
135MP0000015_abnormal_ear_pigmentation0.81622832
136MP0002152_abnormal_brain_morphology0.80573816
137MP0004019_abnormal_vitamin_homeostasis0.80279927
138MP0003385_abnormal_body_wall0.80026036
139MP0002733_abnormal_thermal_nociception0.79724816
140MP0002116_abnormal_craniofacial_bone0.79110365
141MP0004924_abnormal_behavior0.79021134
142MP0005386_behavior/neurological_phenoty0.79021134
143MP0002229_neurodegeneration0.77426562
144MP0005195_abnormal_posterior_eye0.77300779
145MP0002277_abnormal_respiratory_mucosa0.77211488
146MP0000955_abnormal_spinal_cord0.77068622
147MP0002938_white_spotting0.76200744
148MP0002132_abnormal_respiratory_system0.75813262
149MP0002085_abnormal_embryonic_tissue0.75475067
150MP0003942_abnormal_urinary_system0.75004202
151MP0005623_abnormal_meninges_morphology0.73310787

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.26474422
2Abnormal respiratory motile cilium physiology (HP:0012261)6.07485058
3Abnormal ciliary motility (HP:0012262)6.04899556
4Abnormal respiratory epithelium morphology (HP:0012253)4.75303738
5Abnormal respiratory motile cilium morphology (HP:0005938)4.75303738
6Rhinitis (HP:0012384)4.27861251
7Absent/shortened dynein arms (HP:0200106)4.26595249
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.26595249
9Congenital stationary night blindness (HP:0007642)3.84969984
10Male infertility (HP:0003251)3.68779607
11Attenuation of retinal blood vessels (HP:0007843)3.66497824
12Supernumerary spleens (HP:0009799)3.62180536
13Pancreatic fibrosis (HP:0100732)3.58294035
14Peripheral hypomyelination (HP:0007182)3.39064735
15Pancreatic cysts (HP:0001737)3.38648657
16Adrenal hypoplasia (HP:0000835)3.34274728
17Cerebral hypomyelination (HP:0006808)3.29770761
18Neurofibrillary tangles (HP:0002185)3.18069498
19Methylmalonic acidemia (HP:0002912)3.14027145
20Nephronophthisis (HP:0000090)2.92591724
21Mitochondrial inheritance (HP:0001427)2.92059911
22Progressive macrocephaly (HP:0004481)2.90200814
23Chronic bronchitis (HP:0004469)2.88097235
24Methylmalonic aciduria (HP:0012120)2.88016349
25Birth length less than 3rd percentile (HP:0003561)2.87766155
26Abnormal mitochondria in muscle tissue (HP:0008316)2.84562678
27Increased CSF lactate (HP:0002490)2.83585253
28Genital tract atresia (HP:0001827)2.82652228
29Acute encephalopathy (HP:0006846)2.81028752
30Infertility (HP:0000789)2.79767875
31Bronchiectasis (HP:0002110)2.76817791
32Medial flaring of the eyebrow (HP:0010747)2.73295444
33Vaginal atresia (HP:0000148)2.71876241
34Bony spicule pigmentary retinopathy (HP:0007737)2.70448255
35Breast hypoplasia (HP:0003187)2.67967189
36Patellar aplasia (HP:0006443)2.58909256
37Abnormality of midbrain morphology (HP:0002418)2.57174100
38Molar tooth sign on MRI (HP:0002419)2.57174100
39Gait imbalance (HP:0002141)2.55556790
40Pendular nystagmus (HP:0012043)2.55418497
41Aplasia/Hypoplasia of the patella (HP:0006498)2.55198967
42Secondary amenorrhea (HP:0000869)2.53333834
43Hyperinsulinemic hypoglycemia (HP:0000825)2.48831009
44Retinal dysplasia (HP:0007973)2.48410278
45Increased hepatocellular lipid droplets (HP:0006565)2.47925836
46Hepatocellular necrosis (HP:0001404)2.47628739
47Abnormality of the renal medulla (HP:0100957)2.45545151
48Congenital primary aphakia (HP:0007707)2.44306330
49Concave nail (HP:0001598)2.40349285
50Cholecystitis (HP:0001082)2.39764130
51Abnormal gallbladder physiology (HP:0012438)2.39764130
52True hermaphroditism (HP:0010459)2.38720468
53Rib fusion (HP:0000902)2.38113296
54Testicular atrophy (HP:0000029)2.34451031
55Abnormal rod and cone electroretinograms (HP:0008323)2.32901633
56Decreased central vision (HP:0007663)2.32001440
57Hepatic necrosis (HP:0002605)2.31359191
58Optic disc pallor (HP:0000543)2.30807501
59Absent septum pellucidum (HP:0001331)2.29642277
60Chronic hepatic failure (HP:0100626)2.28948975
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28220746
62Chromsome breakage (HP:0040012)2.27257280
63Absent thumb (HP:0009777)2.26627577
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.25770989
65Exertional dyspnea (HP:0002875)2.22639570
66Abnormality of the labia minora (HP:0012880)2.20182911
67Type II lissencephaly (HP:0007260)2.17855432
68Abnormal biliary tract physiology (HP:0012439)2.15625554
69Bile duct proliferation (HP:0001408)2.15625554
70Aplasia/Hypoplasia of the macula (HP:0008059)2.15220485
71Degeneration of the lateral corticospinal tracts (HP:0002314)2.14982842
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14982842
733-Methylglutaconic aciduria (HP:0003535)2.14288990
74Abnormality of the septum pellucidum (HP:0007375)2.12749337
75Abnormality of the pons (HP:0007361)2.12364563
76Poor coordination (HP:0002370)2.12060102
77Aplasia/hypoplasia of the uterus (HP:0008684)2.07935207
78Optic nerve hypoplasia (HP:0000609)2.07582240
79Parakeratosis (HP:0001036)2.06995670
80Large for gestational age (HP:0001520)2.06799320
81Homocystinuria (HP:0002156)2.06604450
82Abnormality of homocysteine metabolism (HP:0010919)2.06604450
83Nephrogenic diabetes insipidus (HP:0009806)2.06562867
84Hypoplasia of the pons (HP:0012110)2.05626622
85CNS hypomyelination (HP:0003429)2.04615271
86Gaze-evoked nystagmus (HP:0000640)2.04490733
87Increased serum lactate (HP:0002151)2.03808710
88Broad-based gait (HP:0002136)2.02118071
89Ketoacidosis (HP:0001993)2.01244784
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.00666725
91Polydipsia (HP:0001959)2.00305824
92Abnormal drinking behavior (HP:0030082)2.00305824
93Abnormality of vitamin B metabolism (HP:0004340)1.99584818
94Chorioretinal atrophy (HP:0000533)1.99488011
95Hypoplasia of the uterus (HP:0000013)1.99238475
96Premature ovarian failure (HP:0008209)1.98581467
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.97421817
98Limb dystonia (HP:0002451)1.96401633
99Bifid tongue (HP:0010297)1.96138989
100Aplasia/Hypoplasia affecting the retina (HP:0008061)1.96012450
101Renal Fanconi syndrome (HP:0001994)1.95497176
102Facial shape deformation (HP:0011334)1.95237933
103Potter facies (HP:0002009)1.95237933
104Nonprogressive disorder (HP:0003680)1.93830692
105Aplasia/Hypoplasia involving the musculature (HP:0001460)1.93554939
106Hypoalbuminemia (HP:0003073)1.93359634
107Abnormal albumin level (HP:0012116)1.93359634
108Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.92579399
109Atelectasis (HP:0100750)1.91801645
110Cerebral edema (HP:0002181)1.91124797
111Lipid accumulation in hepatocytes (HP:0006561)1.90915152
112Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89080484
113Hypothermia (HP:0002045)1.88817692
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88033120
115Abnormality of alanine metabolism (HP:0010916)1.88033120
116Hyperalaninemia (HP:0003348)1.88033120
117Aganglionic megacolon (HP:0002251)1.87972205
118Abnormality of the fovea (HP:0000493)1.87535733
119Progressive inability to walk (HP:0002505)1.86481380
120Absent radius (HP:0003974)1.86166227
121Cystic liver disease (HP:0006706)1.85784898
122Cerebral inclusion bodies (HP:0100314)1.85620720
123Delusions (HP:0000746)1.85347836
124Triphalangeal thumb (HP:0001199)1.82859935
125Sensory axonal neuropathy (HP:0003390)1.82782248
126Acute necrotizing encephalopathy (HP:0006965)1.81978809
127Aplasia involving forearm bones (HP:0009822)1.81884425
128Absent forearm bone (HP:0003953)1.81884425
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.81735412
130Abnormality of chromosome stability (HP:0003220)1.81230670
131Aplasia/Hypoplasia of the lens (HP:0008063)1.81149390
132Microglossia (HP:0000171)1.80954698
133Aplasia involving bones of the upper limbs (HP:0009823)1.80855569
134Aplasia of the phalanges of the hand (HP:0009802)1.80855569
135Aplasia involving bones of the extremities (HP:0009825)1.80855569
136Aplasia of the musculature (HP:0100854)1.80196952
137Abnormality of the vitamin B12 metabolism (HP:0004341)1.77514291
138Multicystic kidney dysplasia (HP:0000003)1.77100355
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76839436
140Abnormality of the lacrimal duct (HP:0011481)1.76539496
141Tubular atrophy (HP:0000092)1.75727595
142Congenital sensorineural hearing impairment (HP:0008527)1.75700926
143Nasolacrimal duct obstruction (HP:0000579)1.74291893
144Lactic acidosis (HP:0003128)1.73808423
145Sclerocornea (HP:0000647)1.73682088
146Abnormality of renal resorption (HP:0011038)1.73471072
147Abnormality of methionine metabolism (HP:0010901)1.72572933
148Aplasia/Hypoplasia of the breasts (HP:0010311)1.71957427
149Hypoplasia of the fovea (HP:0007750)1.71781946
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.71781946
151Male pseudohermaphroditism (HP:0000037)1.71502239
152Meckel diverticulum (HP:0002245)1.71048952
153Ketosis (HP:0001946)1.71004966
154Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70798900
155Hypoplastic pelvis (HP:0008839)1.70677759
156Hemiparesis (HP:0001269)1.70325509
157Facial hemangioma (HP:0000329)1.70051669
158Chin dimple (HP:0010751)1.70025868
159Occipital encephalocele (HP:0002085)1.69941037
160Amniotic constriction ring (HP:0009775)1.69021148
161Abnormality of placental membranes (HP:0011409)1.69021148
162Choroideremia (HP:0001139)1.68778242
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.68463017
164Abolished electroretinogram (ERG) (HP:0000550)1.68423999
165Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67155969
166Dyschromatopsia (HP:0007641)1.66320567
167Rectovaginal fistula (HP:0000143)1.65905384
168Rectal fistula (HP:0100590)1.65905384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.17431049
2PLK44.00147089
3TLK13.87839015
4LATS23.06114311
5STK393.00683286
6TRIM282.96249337
7BMPR22.58837686
8MAP3K62.56741706
9ZAK2.54776653
10WNK32.43006499
11MAP3K122.40592624
12OXSR12.40238624
13MST42.40018493
14DYRK22.39465272
15MAP4K22.26650336
16MOS2.22290411
17BUB12.21267983
18ERBB42.21235047
19CDK192.18617899
20MAPKAPK52.17256035
21STK38L2.09682675
22LATS12.01836498
23PNCK2.00796667
24KSR21.99550091
25GRK11.96666798
26TTK1.95463533
27BRAF1.94971105
28PINK11.92363289
29MUSK1.82056424
30CSNK1G31.80290949
31MAP2K71.72902320
32ARAF1.69162331
33CSNK1G11.66290207
34TESK21.57878295
35NME11.53930381
36CASK1.49945985
37TSSK61.47648748
38VRK21.46687013
39MAPK131.38738271
40PHKG11.37631502
41PHKG21.37631502
42NTRK31.35567997
43TAOK31.33013272
44CSNK1A1L1.32627224
45CDC71.29896431
46CSNK1G21.28703163
47INSRR1.25025587
48MKNK21.24492170
49PAK61.22214541
50EIF2AK11.15954872
51RAF11.15258682
52MARK11.13166854
53EIF2AK31.10988016
54EPHA41.06656107
55MAP3K41.06107441
56PRKCG1.00936358
57STK161.00592572
58MAP2K61.00365838
59AURKA1.00098718
60CDK30.99547038
61CHEK20.98371729
62MAP3K90.95766544
63MKNK10.94071875
64PKN10.92690041
65DAPK20.89229693
66PLK10.88987578
67NUAK10.88635869
68PLK20.88309278
69ACVR1B0.87781918
70LIMK10.86456254
71MAPK150.85587965
72DYRK30.82936570
73PRKCI0.81999937
74ADRBK10.81001070
75BMPR1B0.80409643
76CLK10.77176706
77TNIK0.77115406
78ROCK20.76936698
79STK30.76567270
80SRPK10.75526835
81NEK20.75414233
82PRKD30.74357486
83VRK10.74158044
84ABL20.72046049
85TXK0.71444749
86GRK50.71021123
87WNK40.70235499
88PBK0.69912924
89STK380.69368084
90DMPK0.68669815
91PRKD20.67558197
92BCKDK0.65762728
93GRK70.64900925
94CDK80.63673795
95MAP2K40.63372501
96STK100.62774800
97TAF10.62728888
98MAP3K80.62426680
99MINK10.61936126
100CAMK2A0.60849870
101FGFR20.59682327
102ATR0.59379161
103SGK4940.58189839
104SGK2230.58189839
105DYRK1A0.57807751
106HIPK20.57177907
107NLK0.57172186
108CDK140.57120028
109PRKCE0.56879844
110CAMK2B0.56704020
111CDK90.56218683
112CDK150.54846504
113ERBB30.52767823
114CDK11A0.52214987
115EPHB10.52021615
116MET0.51278305
117CSNK1D0.51258978
118PDK20.50828495
119PAK10.50725479
120CSNK1A10.50279725
121SIK20.49776507
122CDK180.49099653
123BCR0.47760724
124MELK0.47227663
125RPS6KA50.44901907
126ATM0.44415263
127CSNK1E0.42970715
128NTRK20.42759034
129MAPKAPK30.42248315
130PLK30.42118243
131PAK30.41954569
132NTRK10.41816310
133BLK0.41601988
134KSR10.40196544
135FGR0.39353029
136WNK10.38542658
137PRKACA0.37864127
138STK240.37515030
139IRAK10.37510287
140AURKB0.37391614
141NEK10.36835105
142ADRBK20.36787907
143BRSK20.36775492
144CSNK2A10.34809610
145PTK2B0.34250110
146UHMK10.33987415
147CSNK2A20.32541276
148CHUK0.31624500
149MARK20.31187500
150RPS6KB20.30926299
151WEE10.30270696

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.66826511
2RNA polymerase_Homo sapiens_hsa030203.57293445
3Ether lipid metabolism_Homo sapiens_hsa005653.48976762
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.31888686
5Basal transcription factors_Homo sapiens_hsa030223.18065362
6Linoleic acid metabolism_Homo sapiens_hsa005912.63594362
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52045893
8Cell cycle_Homo sapiens_hsa041102.36293855
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.35395292
10Protein export_Homo sapiens_hsa030602.33710406
11Homologous recombination_Homo sapiens_hsa034402.19759940
12RNA degradation_Homo sapiens_hsa030182.16422203
13Fanconi anemia pathway_Homo sapiens_hsa034602.05901842
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98918988
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90708496
16Ovarian steroidogenesis_Homo sapiens_hsa049131.88609393
17Oxidative phosphorylation_Homo sapiens_hsa001901.87152840
18Folate biosynthesis_Homo sapiens_hsa007901.80984273
19Huntingtons disease_Homo sapiens_hsa050161.80347556
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79878126
21Steroid biosynthesis_Homo sapiens_hsa001001.70520371
22Pyrimidine metabolism_Homo sapiens_hsa002401.52354842
23Nucleotide excision repair_Homo sapiens_hsa034201.52289269
24Arachidonic acid metabolism_Homo sapiens_hsa005901.46661111
25Fatty acid elongation_Homo sapiens_hsa000621.46454107
26Selenocompound metabolism_Homo sapiens_hsa004501.43414394
27Parkinsons disease_Homo sapiens_hsa050121.42651007
28Oocyte meiosis_Homo sapiens_hsa041141.38009994
29Sphingolipid metabolism_Homo sapiens_hsa006001.32234626
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29593507
31Proteasome_Homo sapiens_hsa030501.29337878
32Circadian rhythm_Homo sapiens_hsa047101.26177267
33One carbon pool by folate_Homo sapiens_hsa006701.24489233
34Renal cell carcinoma_Homo sapiens_hsa052111.24386017
35Purine metabolism_Homo sapiens_hsa002301.23407218
36Butanoate metabolism_Homo sapiens_hsa006501.19443138
37Ribosome_Homo sapiens_hsa030101.18058442
38Dorso-ventral axis formation_Homo sapiens_hsa043201.17809755
39RNA transport_Homo sapiens_hsa030131.16436995
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15950333
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15120322
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.14370859
43Alzheimers disease_Homo sapiens_hsa050101.13667743
44Non-homologous end-joining_Homo sapiens_hsa034501.12110758
45Tryptophan metabolism_Homo sapiens_hsa003801.11504090
46Serotonergic synapse_Homo sapiens_hsa047261.06016022
47TGF-beta signaling pathway_Homo sapiens_hsa043501.05343389
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03711200
49Caffeine metabolism_Homo sapiens_hsa002320.96436638
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95092931
51Histidine metabolism_Homo sapiens_hsa003400.93030203
52Nitrogen metabolism_Homo sapiens_hsa009100.92748744
53Long-term depression_Homo sapiens_hsa047300.91853737
54Base excision repair_Homo sapiens_hsa034100.90342826
55Morphine addiction_Homo sapiens_hsa050320.88219137
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87115913
57Propanoate metabolism_Homo sapiens_hsa006400.86595276
58Axon guidance_Homo sapiens_hsa043600.86566476
59Cocaine addiction_Homo sapiens_hsa050300.85458186
60GABAergic synapse_Homo sapiens_hsa047270.84784398
61Insulin secretion_Homo sapiens_hsa049110.83750133
62Spliceosome_Homo sapiens_hsa030400.83603591
63p53 signaling pathway_Homo sapiens_hsa041150.83152559
64Olfactory transduction_Homo sapiens_hsa047400.81191820
65Vitamin digestion and absorption_Homo sapiens_hsa049770.81091721
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78678935
67DNA replication_Homo sapiens_hsa030300.78451697
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77610850
69Phototransduction_Homo sapiens_hsa047440.77553184
70Ras signaling pathway_Homo sapiens_hsa040140.77530882
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76668023
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.74555939
73Wnt signaling pathway_Homo sapiens_hsa043100.73610974
74mRNA surveillance pathway_Homo sapiens_hsa030150.72336178
75Circadian entrainment_Homo sapiens_hsa047130.71056204
76Hedgehog signaling pathway_Homo sapiens_hsa043400.70740588
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70410668
78Mismatch repair_Homo sapiens_hsa034300.69849004
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68790779
80GnRH signaling pathway_Homo sapiens_hsa049120.66190091
81Pyruvate metabolism_Homo sapiens_hsa006200.65982080
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65651022
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64175353
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62979612
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.59683576
86Choline metabolism in cancer_Homo sapiens_hsa052310.57896881
87Chemical carcinogenesis_Homo sapiens_hsa052040.57040450
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55490575
89Peroxisome_Homo sapiens_hsa041460.55106380
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54155645
91Glutamatergic synapse_Homo sapiens_hsa047240.53867581
92Pancreatic cancer_Homo sapiens_hsa052120.53332387
93Synaptic vesicle cycle_Homo sapiens_hsa047210.52024603
94Collecting duct acid secretion_Homo sapiens_hsa049660.51902169
95Notch signaling pathway_Homo sapiens_hsa043300.51613540
96Cardiac muscle contraction_Homo sapiens_hsa042600.47633157
97Sulfur relay system_Homo sapiens_hsa041220.47336751
98Regulation of autophagy_Homo sapiens_hsa041400.47079057
99Calcium signaling pathway_Homo sapiens_hsa040200.47000275
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.46828895
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46771602
102Arginine and proline metabolism_Homo sapiens_hsa003300.46226617
103Endocytosis_Homo sapiens_hsa041440.44433807
104Salivary secretion_Homo sapiens_hsa049700.44375469
105* Metabolic pathways_Homo sapiens_hsa011000.43882860
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43808383
107Hippo signaling pathway_Homo sapiens_hsa043900.42257519
108Sulfur metabolism_Homo sapiens_hsa009200.40846951
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.40666536
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40393934
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.40359320
112* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40069350
113Glutathione metabolism_Homo sapiens_hsa004800.39688976
114MAPK signaling pathway_Homo sapiens_hsa040100.37651737
115Basal cell carcinoma_Homo sapiens_hsa052170.37546584
116Nicotine addiction_Homo sapiens_hsa050330.37340646
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.37247668
118beta-Alanine metabolism_Homo sapiens_hsa004100.36159061
119Prostate cancer_Homo sapiens_hsa052150.36003037
120MicroRNAs in cancer_Homo sapiens_hsa052060.34984940
121Taste transduction_Homo sapiens_hsa047420.34572141
122ErbB signaling pathway_Homo sapiens_hsa040120.34479566
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33839965
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33482816
125Colorectal cancer_Homo sapiens_hsa052100.33308202
126Epstein-Barr virus infection_Homo sapiens_hsa051690.33002624
127Other glycan degradation_Homo sapiens_hsa005110.32679808
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.32584003
129Mineral absorption_Homo sapiens_hsa049780.32371752
130Prolactin signaling pathway_Homo sapiens_hsa049170.31840635
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31611526
132Melanoma_Homo sapiens_hsa052180.30052191
133Amphetamine addiction_Homo sapiens_hsa050310.29731465
134Alcoholism_Homo sapiens_hsa050340.28380378
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27809158
136Shigellosis_Homo sapiens_hsa051310.26466086
137Retinol metabolism_Homo sapiens_hsa008300.25861123
138Dopaminergic synapse_Homo sapiens_hsa047280.25555708

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