B3GNT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)8.84109605
2diol metabolic process (GO:0034311)8.23163360
3sphingoid metabolic process (GO:0046519)7.63617144
4axonemal dynein complex assembly (GO:0070286)7.27866168
5cilium or flagellum-dependent cell motility (GO:0001539)7.07412629
6motile cilium assembly (GO:0044458)5.54874107
7cilium movement (GO:0003341)5.53030527
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.38486154
9pre-miRNA processing (GO:0031054)5.21623064
10negative regulation of glycoprotein biosynthetic process (GO:0010561)4.79426131
11epithelial cilium movement (GO:0003351)4.65234955
12DNA unwinding involved in DNA replication (GO:0006268)4.61744878
13ribosomal small subunit assembly (GO:0000028)4.58012300
14DNA double-strand break processing (GO:0000729)4.36976265
15keratinocyte proliferation (GO:0043616)4.23190081
16regulation of protein glycosylation (GO:0060049)4.23047948
17bundle of His cell to Purkinje myocyte communication (GO:0086069)4.21406486
18regulation of pigment cell differentiation (GO:0050932)4.19342341
19germinal center formation (GO:0002467)4.03544798
20DNA topological change (GO:0006265)4.02385877
21negative regulation of histone methylation (GO:0031061)4.00391565
22hemidesmosome assembly (GO:0031581)4.00139322
23DNA strand elongation involved in DNA replication (GO:0006271)3.93255123
24B cell receptor signaling pathway (GO:0050853)3.91511934
25regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.91407717
26protein-chromophore linkage (GO:0018298)3.84133080
27regulation of histone H3-K9 methylation (GO:0051570)3.83184135
28sulfate transmembrane transport (GO:1902358)3.79754015
29desmosome organization (GO:0002934)3.78207376
30negative regulation of RNA splicing (GO:0033119)3.77575283
31telomere maintenance via semi-conservative replication (GO:0032201)3.77539402
32axoneme assembly (GO:0035082)3.76272380
33DNA strand elongation (GO:0022616)3.76142834
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.72172777
35mitotic sister chromatid cohesion (GO:0007064)3.68754947
36negative regulation of phagocytosis (GO:0050765)3.63177433
37nuclear pore complex assembly (GO:0051292)3.59593333
38mitotic recombination (GO:0006312)3.57321297
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53558437
40negative regulation of glycoprotein metabolic process (GO:1903019)3.51143342
41diterpenoid biosynthetic process (GO:0016102)3.50165072
42telomere maintenance via recombination (GO:0000722)3.47392575
43DNA replication initiation (GO:0006270)3.43474909
44regulation of transforming growth factor beta2 production (GO:0032909)3.42417535
45left/right axis specification (GO:0070986)3.40905136
46DNA methylation involved in gamete generation (GO:0043046)3.39364029
47nuclear pore organization (GO:0006999)3.37583111
48regulation of keratinocyte proliferation (GO:0010837)3.32817126
49viral transcription (GO:0019083)3.30847731
50kinetochore organization (GO:0051383)3.29450151
51protein localization to kinetochore (GO:0034501)3.26036285
52sulfate transport (GO:0008272)3.24026141
53response to peptidoglycan (GO:0032494)3.23682237
54response to xenobiotic stimulus (GO:0009410)3.22886621
55translational termination (GO:0006415)3.19824701
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.19559676
57histone mRNA metabolic process (GO:0008334)3.18679735
58cellular response to zinc ion (GO:0071294)3.18676316
59regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.17825514
60pyrimidine-containing compound transmembrane transport (GO:0072531)3.15202446
61positive regulation of developmental pigmentation (GO:0048087)3.13350156
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.11799708
63vitamin transmembrane transport (GO:0035461)3.06411078
64positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.05989944
65dosage compensation (GO:0007549)3.03379778
66translesion synthesis (GO:0019985)3.01856871
67centriole assembly (GO:0098534)3.01692878
68nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99814018
69ATP-dependent chromatin remodeling (GO:0043044)2.99278611
70protein-DNA complex disassembly (GO:0032986)2.99165965
71nucleosome disassembly (GO:0006337)2.99165965
72negative regulation of keratinocyte proliferation (GO:0010839)2.97705303
73maturation of SSU-rRNA (GO:0030490)2.97592211
74DNA replication-independent nucleosome organization (GO:0034724)2.97472452
75DNA replication-independent nucleosome assembly (GO:0006336)2.97472452
76telomere maintenance via telomere lengthening (GO:0010833)2.97274092
77negative regulation of mRNA processing (GO:0050686)2.97162020
78regulation of nuclear cell cycle DNA replication (GO:0033262)2.95417949
79SMAD protein complex assembly (GO:0007183)2.94136006
80DNA duplex unwinding (GO:0032508)2.93788112
81protein localization to chromosome, centromeric region (GO:0071459)2.93179494
82regulation of cilium movement (GO:0003352)2.92262219
83positive regulation of leukocyte degranulation (GO:0043302)2.92250335
84regulation of interleukin-5 production (GO:0032674)2.91284815
85DNA geometric change (GO:0032392)2.91110532
86CENP-A containing nucleosome assembly (GO:0034080)2.90990894
87spliceosomal complex assembly (GO:0000245)2.88926173
88alternative mRNA splicing, via spliceosome (GO:0000380)2.87076580
89keratinocyte differentiation (GO:0030216)2.86680825
90regulation of telomere maintenance via telomerase (GO:0032210)2.85800868
91DNA replication checkpoint (GO:0000076)2.85728327
92histone mRNA catabolic process (GO:0071044)2.84464293
933-UTR-mediated mRNA stabilization (GO:0070935)2.84016549
94regulation of DNA endoreduplication (GO:0032875)2.83674108
95mitotic nuclear envelope disassembly (GO:0007077)2.83663939
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.83422746
97positive regulation of mast cell degranulation (GO:0043306)2.83422746
98antigen processing and presentation of endogenous antigen (GO:0019883)2.81514488
99cellular response to ethanol (GO:0071361)2.80866643
100mRNA stabilization (GO:0048255)2.80646854
101RNA stabilization (GO:0043489)2.80646854
102mitotic nuclear envelope reassembly (GO:0007084)2.79897191
103nuclear envelope reassembly (GO:0031468)2.79897191
104chromatin remodeling at centromere (GO:0031055)2.79034317
105telomere maintenance (GO:0000723)2.78950461
106mRNA splice site selection (GO:0006376)2.78546265
107meiotic chromosome segregation (GO:0045132)2.77507851
108mismatch repair (GO:0006298)2.76486339
109inflammatory response to antigenic stimulus (GO:0002437)2.76169966
110regulation of meiosis I (GO:0060631)2.75685611
111iron ion import (GO:0097286)2.75249644
112interleukin-1-mediated signaling pathway (GO:0070498)2.75101541
113mitotic chromosome condensation (GO:0007076)2.74956543
114translational elongation (GO:0006414)2.74461509
115T-helper 1 type immune response (GO:0042088)2.74270748
116telomere organization (GO:0032200)2.73848645
117positive regulation of gamma-delta T cell activation (GO:0046645)2.71428373
118regulation of B cell differentiation (GO:0045577)2.70888930
119spindle assembly checkpoint (GO:0071173)2.69358340
120negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.69085388
121pore complex assembly (GO:0046931)2.67948403
122termination of RNA polymerase II transcription (GO:0006369)2.66823469
123kinetochore assembly (GO:0051382)2.66543693
124mRNA splicing, via spliceosome (GO:0000398)2.66472016
125RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66472016
126DNA conformation change (GO:0071103)2.66050979
127macrophage activation involved in immune response (GO:0002281)2.65652378
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65301512
129nuclear-transcribed mRNA catabolic process (GO:0000956)2.63845588
130positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.63182416
131flavonoid metabolic process (GO:0009812)2.63048157
132mitotic spindle assembly checkpoint (GO:0007094)2.62757119
133RNA splicing, via transesterification reactions (GO:0000375)2.62227999
134DNA replication-dependent nucleosome organization (GO:0034723)2.62046054
135DNA replication-dependent nucleosome assembly (GO:0006335)2.62046054
136negative regulation of sister chromatid segregation (GO:0033046)2.61553302
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.61553302
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.61553302
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.61553302
140regulation of sister chromatid cohesion (GO:0007063)2.60706122
141membrane disassembly (GO:0030397)2.60208042
142nuclear envelope disassembly (GO:0051081)2.60208042
143regulation of telomere maintenance (GO:0032204)2.60179651
144embryonic process involved in female pregnancy (GO:0060136)2.60046606
145sister chromatid segregation (GO:0000819)2.59174161
146negative regulation of chromosome segregation (GO:0051985)2.57770635
147ribosomal small subunit biogenesis (GO:0042274)2.56997329
148regulation of interleukin-8 biosynthetic process (GO:0045414)2.56896641
149negative regulation of histone modification (GO:0031057)2.56773872
150spindle checkpoint (GO:0031577)2.56622248
151negative regulation of interleukin-8 production (GO:0032717)2.53325657
152mitotic spindle checkpoint (GO:0071174)2.53091782
153regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.52977599
154neutrophil activation involved in immune response (GO:0002283)2.52224347
155chromatin assembly or disassembly (GO:0006333)2.52175482
156protein complex disassembly (GO:0043241)2.52011798
157regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51853309
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51841184
159centriole replication (GO:0007099)2.51577260
160negative regulation of chromatin modification (GO:1903309)2.51420004
161attachment of spindle microtubules to kinetochore (GO:0008608)2.50952988
162positive regulation of heat generation (GO:0031652)2.50596775
163superoxide anion generation (GO:0042554)2.47147460
164positive regulation of mast cell activation (GO:0033005)2.46356699
165establishment of skin barrier (GO:0061436)2.43733261
166* O-glycan processing (GO:0016266)2.42551722
167regulation of vitamin metabolic process (GO:0030656)2.41839732
168histamine secretion (GO:0001821)2.38799513
169cellular response to thyroid hormone stimulus (GO:0097067)2.36748087
170nodal signaling pathway (GO:0038092)2.36339919
171sulfur compound transport (GO:0072348)2.36229202
172retinoic acid metabolic process (GO:0042573)2.35429347
173hypotonic response (GO:0006971)2.35247339
174cilium organization (GO:0044782)2.29867682
175regulation of vitamin D biosynthetic process (GO:0060556)2.29603340
176positive regulation of toll-like receptor signaling pathway (GO:0034123)2.29102906
177sphingolipid biosynthetic process (GO:0030148)2.28238563
178positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.27701533
179regulation of mast cell activation (GO:0033003)2.27698801
180interleukin-6-mediated signaling pathway (GO:0070102)2.27539994
181G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.26789004
182response to nitrosative stress (GO:0051409)2.25288074
183epidermal cell differentiation (GO:0009913)2.23619137
184eosinophil chemotaxis (GO:0048245)2.22716920
185regulation of transforming growth factor beta production (GO:0071634)2.21126242
186eosinophil migration (GO:0072677)2.20752404
187multicellular organismal water homeostasis (GO:0050891)2.19455657
188phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.18999915
189sphingomyelin metabolic process (GO:0006684)2.18918775
190cellular response to exogenous dsRNA (GO:0071360)2.18729363
191regulation of metalloenzyme activity (GO:0048552)2.18171068
192positive regulation of monocyte chemotaxis (GO:0090026)2.17313160
193cellular extravasation (GO:0045123)2.17189242
194regulation of interferon-beta biosynthetic process (GO:0045357)2.16658646
195regulation of interleukin-12 biosynthetic process (GO:0045075)2.16326521
196cilium assembly (GO:0042384)2.16099248
197regulation of interleukin-6 biosynthetic process (GO:0045408)2.16027841
198negative regulation of stem cell proliferation (GO:2000647)2.15941754
199glycosphingolipid catabolic process (GO:0046479)2.15527082
200UDP-N-acetylglucosamine metabolic process (GO:0006047)2.14833174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.37900420
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.25895183
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.31919092
4MYC_22102868_ChIP-Seq_BL_Human3.12672661
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00834450
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.90252013
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.87623353
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.85861725
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.77878046
10CIITA_25753668_ChIP-Seq_RAJI_Human2.63741517
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.60985342
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60882211
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.55973888
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.52954436
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50592960
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43379942
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.37239833
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34868609
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24274729
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18397602
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18131747
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17902337
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15106016
24VDR_21846776_ChIP-Seq_THP-1_Human2.05709553
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02797845
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00772960
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00251349
28E2F7_22180533_ChIP-Seq_HELA_Human10.2779339
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.98601311
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.97943480
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96386115
32* TP63_23658742_ChIP-Seq_EP156T_Human1.96273323
33ELK1_19687146_ChIP-ChIP_HELA_Human1.96208483
34VDR_23849224_ChIP-Seq_CD4+_Human1.94049632
35XRN2_22483619_ChIP-Seq_HELA_Human1.93839863
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89491754
37ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86595224
38* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.84828262
39IGF1R_20145208_ChIP-Seq_DFB_Human1.84560548
40AR_21572438_ChIP-Seq_LNCaP_Human1.83444438
41FOXP3_21729870_ChIP-Seq_TREG_Human1.82603823
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81821918
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80298375
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79972281
45* CJUN_26792858_Chip-Seq_BT549_Human1.79417248
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78450561
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.77484734
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74021408
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72646588
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70645755
51SCL_19346495_ChIP-Seq_HPC-7_Human1.69864225
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68746260
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68582603
54TP53_16413492_ChIP-PET_HCT116_Human1.68327130
55* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68268821
56* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68268821
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66157581
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65739971
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65353717
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.64475664
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.64220804
62VDR_24787735_ChIP-Seq_THP-1_Human1.63653822
63VDR_22108803_ChIP-Seq_LS180_Human1.63558329
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61767418
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59896090
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.58553120
67TP53_18474530_ChIP-ChIP_U2OS_Human1.57673645
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57294168
69ER_23166858_ChIP-Seq_MCF-7_Human1.56375408
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55691858
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53267044
72* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53017422
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.49424144
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49186391
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.48840196
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48740848
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.48692393
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48319141
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47394436
80SMAD3_21741376_ChIP-Seq_HESCs_Human1.46987845
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46060100
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45097918
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45003628
84SPI1_23547873_ChIP-Seq_NB4_Human1.44473317
85GABP_17652178_ChIP-ChIP_JURKAT_Human1.42766655
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42639955
87GATA4_25053715_ChIP-Seq_YYC3_Human1.42172985
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42144153
89TTF2_22483619_ChIP-Seq_HELA_Human1.41810703
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41235809
91MYB_26560356_Chip-Seq_TH2_Human1.40648256
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40603640
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40266524
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39633606
95MYB_26560356_Chip-Seq_TH1_Human1.38793123
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38653892
97CDX2_22108803_ChIP-Seq_LS180_Human1.38210374
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36136501
99P63_26484246_Chip-Seq_KERATINOCYTES_Human1.35779532
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35611546
101* P300_19829295_ChIP-Seq_ESCs_Human1.35449516
102UTX_26944678_Chip-Seq_JUKART_Human1.34442293
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34244588
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33500562
105MAF_26560356_Chip-Seq_TH1_Human1.32856272
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32515475
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.32254558
108ETS1_20019798_ChIP-Seq_JURKAT_Human1.31615983
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31522259
110CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30036133
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.28632123
112* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27066869
113CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27040595
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26738961
115SOX2_20726797_ChIP-Seq_SW620_Human1.26640855
116AHR_22903824_ChIP-Seq_MCF-7_Human1.26255614
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25787695
118* SMAD4_21799915_ChIP-Seq_A2780_Human1.25354254
119STAT3_23295773_ChIP-Seq_U87_Human1.24951450
120* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24913698
121TCF7_22412390_ChIP-Seq_EML_Mouse1.24501763
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24424681
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.24122559
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23890112
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23683929
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21563801
127GBX2_23144817_ChIP-Seq_PC3_Human1.21103352
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20900319
129AR_25329375_ChIP-Seq_VCAP_Human1.20759193
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19823610
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19679649
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19205502
133THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19039256
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17796054
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17796054
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17381526
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16842188
138ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16835123
139TCF4_22108803_ChIP-Seq_LS180_Human1.16098114
140AR_21909140_ChIP-Seq_LNCAP_Human1.16036986
141SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15789888
142ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15565459
143SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15316714
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14466309
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14051974
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13593778
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12811317
148* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12200082
149KDM5A_27292631_Chip-Seq_BREAST_Human1.11894773
150PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11216678
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11065548
152SMAD3_21741376_ChIP-Seq_EPCs_Human1.10621904
153* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.10575692
154* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10212405
155NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10036634
156NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10036634
157FLI1_27457419_Chip-Seq_LIVER_Mouse1.09932378
158GABP_19822575_ChIP-Seq_HepG2_Human1.09542006
159RXR_22108803_ChIP-Seq_LS180_Human1.09029763
160TCF4_23295773_ChIP-Seq_U87_Human1.08965879
161FOXA1_25552417_ChIP-Seq_VCAP_Human1.08951384
162STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08365659
163MYC_18940864_ChIP-ChIP_HL60_Human1.08338466
164ESR1_21235772_ChIP-Seq_MCF-7_Human1.07999930
165PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07620144
166SOX2_19829295_ChIP-Seq_ESCs_Human1.07583155
167NANOG_19829295_ChIP-Seq_ESCs_Human1.07583155
168EZH2_27294783_Chip-Seq_NPCs_Mouse1.07526231
169VDR_24763502_ChIP-Seq_THP-1_Human1.06865419
170CBP_20019798_ChIP-Seq_JUKART_Human1.06426770
171IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06426770
172SMAD4_21741376_ChIP-Seq_HESCs_Human1.06102299
173NFE2_27457419_Chip-Seq_LIVER_Mouse1.05867502
174PRDM14_20953172_ChIP-Seq_ESCs_Human1.04911658
175RUNX1_22412390_ChIP-Seq_EML_Mouse1.04779075
176SMAD4_21741376_ChIP-Seq_EPCs_Human1.04704985
177CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04622489
178HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04397042
179EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04315750
180SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04112767
181SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04083772
182HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02096398
183JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01691421
184E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00471335
185NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00360286
186E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98899404
187STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.98507871
188DCP1A_22483619_ChIP-Seq_HELA_Human0.97597613
189SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94521852
190POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93415428
191ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91648811
192MYB_21317192_ChIP-Seq_ERMYB_Mouse0.88863762
193TFEB_21752829_ChIP-Seq_HELA_Human0.86642016
194IRF1_19129219_ChIP-ChIP_H3396_Human0.86576363
195* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84547068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.92888007
2MP0002837_dystrophic_cardiac_calcinosis4.50393098
3MP0002653_abnormal_ependyma_morphology4.19389877
4MP0003045_fibrosis3.86949647
5MP0003136_yellow_coat_color3.37068783
6MP0010094_abnormal_chromosome_stability3.31761817
7MP0003077_abnormal_cell_cycle3.06855514
8MP0005171_absent_coat_pigmentation2.91173026
9MP0002396_abnormal_hematopoietic_system2.87265440
10MP0004957_abnormal_blastocyst_morpholog2.79181839
11MP0003693_abnormal_embryo_hatching2.64572483
12MP0000537_abnormal_urethra_morphology2.63510433
13MP0003111_abnormal_nucleus_morphology2.55635324
14MP0003646_muscle_fatigue2.52209738
15MP0010234_abnormal_vibrissa_follicle2.50844890
16MP0001835_abnormal_antigen_presentation2.37588647
17MP0008007_abnormal_cellular_replicative2.36267783
18* MP0001800_abnormal_humoral_immune2.33417051
19MP0002138_abnormal_hepatobiliary_system2.32540311
20MP0003195_calcinosis2.29646681
21MP0004808_abnormal_hematopoietic_stem2.16214376
22MP0003315_abnormal_perineum_morphology2.15176073
23MP0004043_abnormal_pH_regulation2.12751193
24MP0002168_other_aberrant_phenotype2.10100436
25MP0002398_abnormal_bone_marrow2.08242203
26MP0003950_abnormal_plasma_membrane2.01720070
27MP0005085_abnormal_gallbladder_physiolo1.97680878
28MP0008058_abnormal_DNA_repair1.97258514
29MP0003121_genomic_imprinting1.95892886
30MP0006082_CNS_inflammation1.95876771
31MP0004264_abnormal_extraembryonic_tissu1.93283679
32MP0010352_gastrointestinal_tract_polyps1.85907591
33* MP0002452_abnormal_antigen_presenting1.84622275
34MP0003123_paternal_imprinting1.82480575
35MP0003724_increased_susceptibility_to1.82181543
36MP0005387_immune_system_phenotype1.81221024
37MP0001790_abnormal_immune_system1.81221024
38MP0003453_abnormal_keratinocyte_physiol1.78485668
39MP0009764_decreased_sensitivity_to1.78313516
40MP0003763_abnormal_thymus_physiology1.72454176
41MP0000350_abnormal_cell_proliferation1.71778916
42MP0008875_abnormal_xenobiotic_pharmacok1.70368212
43* MP0002420_abnormal_adaptive_immunity1.68927420
44MP0000579_abnormal_nail_morphology1.68614866
45MP0000427_abnormal_hair_cycle1.67057466
46MP0003567_abnormal_fetal_cardiomyocyte1.66612816
47* MP0000689_abnormal_spleen_morphology1.65336728
48* MP0001819_abnormal_immune_cell1.64871234
49* MP0000716_abnormal_immune_system1.63980100
50MP0000703_abnormal_thymus_morphology1.63931055
51MP0008932_abnormal_embryonic_tissue1.63842806
52MP0005164_abnormal_response_to1.62390903
53MP0003191_abnormal_cellular_cholesterol1.60414010
54MP0004381_abnormal_hair_follicle1.58261978
55MP0008004_abnormal_stomach_pH1.56601214
56MP0000490_abnormal_crypts_of1.55128344
57* MP0002722_abnormal_immune_system1.53781651
58MP0002332_abnormal_exercise_endurance1.51411979
59MP0001730_embryonic_growth_arrest1.51276284
60MP0002277_abnormal_respiratory_mucosa1.49755243
61MP0001216_abnormal_epidermal_layer1.49278712
62* MP0002723_abnormal_immune_serum1.48508078
63MP0003300_gastrointestinal_ulcer1.46307695
64* MP0002429_abnormal_blood_cell1.46251983
65MP0004197_abnormal_fetal_growth/weight/1.45830639
66MP0004147_increased_porphyrin_level1.45167479
67MP0003705_abnormal_hypodermis_morpholog1.44761930
68MP0005174_abnormal_tail_pigmentation1.42181556
69MP0000569_abnormal_digit_pigmentation1.40796077
70MP0000465_gastrointestinal_hemorrhage1.40449868
71MP0005671_abnormal_response_to1.39952201
72MP0003879_abnormal_hair_cell1.38373825
73MP0006054_spinal_hemorrhage1.38311901
74MP0006292_abnormal_olfactory_placode1.36101723
75MP0003828_pulmonary_edema1.36012431
76MP0002419_abnormal_innate_immunity1.32033285
77MP0003656_abnormal_erythrocyte_physiolo1.31352084
78MP0000685_abnormal_immune_system1.31249660
79MP0002132_abnormal_respiratory_system1.31228364
80MP0004782_abnormal_surfactant_physiolog1.30999253
81MP0001697_abnormal_embryo_size1.30367798
82MP0005380_embryogenesis_phenotype1.29525937
83MP0001672_abnormal_embryogenesis/_devel1.29525937
84MP0004484_altered_response_of1.28582594
85MP0005000_abnormal_immune_tolerance1.28285835
86MP0000516_abnormal_urinary_system1.25242818
87MP0005367_renal/urinary_system_phenotyp1.25242818
88MP0002060_abnormal_skin_morphology1.24555719
89MP0002085_abnormal_embryonic_tissue1.24249897
90MP0002796_impaired_skin_barrier1.22837309
91MP0003984_embryonic_growth_retardation1.22185129
92MP0003787_abnormal_imprinting1.20944015
93MP0002088_abnormal_embryonic_growth/wei1.20888092
94MP0002084_abnormal_developmental_patter1.20492244
95MP0003890_abnormal_embryonic-extraembry1.19357482
96MP0002019_abnormal_tumor_incidence1.18382900
97MP0001501_abnormal_sleep_pattern1.18258812
98MP0002166_altered_tumor_susceptibility1.17772696
99MP0002086_abnormal_extraembryonic_tissu1.17330117
100MP0002098_abnormal_vibrissa_morphology1.16413810
101MP0009053_abnormal_anal_canal1.16117865
102MP0005395_other_phenotype1.16005733
103MP0009840_abnormal_foam_cell1.15980702
104MP0004947_skin_inflammation1.14475802
105MP0002095_abnormal_skin_pigmentation1.13907141
106MP0001293_anophthalmia1.13861315
107MP0000467_abnormal_esophagus_morphology1.13279975
108MP0003436_decreased_susceptibility_to1.07783270
109MP0003303_peritoneal_inflammation1.07479531
110MP0004883_abnormal_blood_vessel1.06820792
111MP0005365_abnormal_bile_salt1.05852623
112MP0003385_abnormal_body_wall1.04372106
113MP0000383_abnormal_hair_follicle1.04122193
114MP0005025_abnormal_response_to1.03753119
115MP0001851_eye_inflammation1.03253806
116* MP0002080_prenatal_lethality1.02914326
117MP0003943_abnormal_hepatobiliary_system1.01910924
118MP0005166_decreased_susceptibility_to1.01282287
119MP0005076_abnormal_cell_differentiation1.00443157
120MP0005075_abnormal_melanosome_morpholog0.99665463
121MP0000313_abnormal_cell_death0.97423299
122MP0005451_abnormal_body_composition0.96952320
123MP0008877_abnormal_DNA_methylation0.96260438
124MP0002751_abnormal_autonomic_nervous0.96017901
125MP0002405_respiratory_system_inflammati0.95968558
126MP0005397_hematopoietic_system_phenotyp0.94672366
127MP0001545_abnormal_hematopoietic_system0.94672366
128MP0000377_abnormal_hair_follicle0.92794418
129MP0001845_abnormal_inflammatory_respons0.90609086
130MP0002938_white_spotting0.89927082
131MP0005023_abnormal_wound_healing0.89101866
132MP0003937_abnormal_limbs/digits/tail_de0.89033815
133MP0003938_abnormal_ear_development0.88974443
134MP0010771_integument_phenotype0.88428741
135MP0000428_abnormal_craniofacial_morphol0.88303660
136MP0002697_abnormal_eye_size0.88168423
137MP0003119_abnormal_digestive_system0.86554796
138MP0002127_abnormal_cardiovascular_syste0.84966739
139MP0003935_abnormal_craniofacial_develop0.84933011
140MP0008469_abnormal_protein_level0.83931160
141MP0010678_abnormal_skin_adnexa0.83095924
142MP0010155_abnormal_intestine_physiology0.82645179
143MP0004019_abnormal_vitamin_homeostasis0.82385588
144MP0001765_abnormal_ion_homeostasis0.82344671
145MP0003221_abnormal_cardiomyocyte_apopto0.82044824
146MP0001873_stomach_inflammation0.81837426
147MP0005165_increased_susceptibility_to0.81709238
148MP0002006_tumorigenesis0.80737134
149MP0000733_abnormal_muscle_development0.80515595
150MP0003075_altered_response_to0.80186033
151MP0002009_preneoplasia0.79463828
152MP0000470_abnormal_stomach_morphology0.78119789
153MP0002282_abnormal_trachea_morphology0.78040254
154MP0009785_altered_susceptibility_to0.77603282
155MP0003122_maternal_imprinting0.77446991
156MP0002092_abnormal_eye_morphology0.77399790
157MP0002148_abnormal_hypersensitivity_rea0.76997241
158MP0000049_abnormal_middle_ear0.76848776
159MP0001286_abnormal_eye_development0.76846561
160MP0003115_abnormal_respiratory_system0.76389498
161MP0005360_urolithiasis0.76228576
162MP0003866_abnormal_defecation0.75652580
163MP0003252_abnormal_bile_duct0.75212257
164MP0002932_abnormal_joint_morphology0.75129807
165MP0000749_muscle_degeneration0.74878941
166MP0009278_abnormal_bone_marrow0.74502451
167MP0001191_abnormal_skin_condition0.74032471
168MP0005319_abnormal_enzyme/_coenzyme0.73570915
169MP0009703_decreased_birth_body0.73528329
170MP0003183_abnormal_peptide_metabolism0.73494623
171MP0002249_abnormal_larynx_morphology0.73316576
172MP0009765_abnormal_xenobiotic_induced0.72335191
173MP0003566_abnormal_cell_adhesion0.69505849
174MP0009115_abnormal_fat_cell0.69015209
175MP0005464_abnormal_platelet_physiology0.68688887
176MP0003806_abnormal_nucleotide_metabolis0.68118263
177MP0001533_abnormal_skeleton_physiology0.67590766
178MP0005409_darkened_coat_color0.65621870

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.80214716
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.80214716
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.54926646
4Abnormal respiratory epithelium morphology (HP:0012253)6.14904913
5Abnormal respiratory motile cilium morphology (HP:0005938)6.14904913
6Abnormal ciliary motility (HP:0012262)6.11703531
7Abnormal respiratory motile cilium physiology (HP:0012261)5.95033024
8Amelogenesis imperfecta (HP:0000705)5.39925415
9Rhinitis (HP:0012384)4.93116122
10Chronic bronchitis (HP:0004469)4.62835706
11Agammaglobulinemia (HP:0004432)4.51670341
12Bronchiectasis (HP:0002110)4.31068765
13Thick nail (HP:0001805)4.13617767
14IgM deficiency (HP:0002850)3.56366845
15Gastrointestinal stroma tumor (HP:0100723)3.51948225
16Medulloblastoma (HP:0002885)3.51670226
17Right ventricular cardiomyopathy (HP:0011663)3.51172119
18Parakeratosis (HP:0001036)3.49770364
19Recurrent bronchitis (HP:0002837)3.45089034
20Plantar hyperkeratosis (HP:0007556)3.42163121
21Nasal polyposis (HP:0100582)3.30803004
22Hyperactive renin-angiotensin system (HP:0000841)3.24238315
23Pancreatic cysts (HP:0001737)3.22470633
24Alopecia of scalp (HP:0002293)3.19527073
25Abnormal number of incisors (HP:0011064)3.11608553
26Palmoplantar hyperkeratosis (HP:0000972)3.11039914
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10102237
28Short 4th metacarpal (HP:0010044)3.10102237
29Onycholysis (HP:0001806)3.07549019
30Milia (HP:0001056)3.06850528
31Hematochezia (HP:0002573)3.04813381
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.03214356
33Lymphopenia (HP:0001888)3.01940581
34Cellulitis (HP:0100658)2.99010061
35Palmar hyperkeratosis (HP:0010765)2.98918710
36Decreased circulating renin level (HP:0003351)2.98084597
37Spontaneous hematomas (HP:0007420)2.95888785
38Colon cancer (HP:0003003)2.95736980
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.92841303
40Birth length less than 3rd percentile (HP:0003561)2.92010006
41Verrucae (HP:0200043)2.90999344
42Papilloma (HP:0012740)2.90999344
43Abnormality of the nasal mucosa (HP:0000433)2.81367073
44Fatigue (HP:0012378)2.80850174
45Abnormality of nail color (HP:0100643)2.79489569
46Acanthocytosis (HP:0001927)2.79159815
47Volvulus (HP:0002580)2.74001783
48Recurrent sinusitis (HP:0011108)2.72689674
49Thrombocytosis (HP:0001894)2.72425300
50Patellar aplasia (HP:0006443)2.71258548
51Recurrent viral infections (HP:0004429)2.69382029
52Panhypogammaglobulinemia (HP:0003139)2.64614335
53Reticulocytopenia (HP:0001896)2.64545784
54Abnormality of the intervertebral disk (HP:0005108)2.63996227
55Chronic hepatic failure (HP:0100626)2.59308712
56Meningitis (HP:0001287)2.58373111
57Syringomyelia (HP:0003396)2.53159731
58Spinal cord lesions (HP:0100561)2.53159731
59Hypoplastic labia majora (HP:0000059)2.53060749
60Hyperkalemia (HP:0002153)2.52269357
61Pancreatic fibrosis (HP:0100732)2.52128085
62Lymphoma (HP:0002665)2.51185454
63Recurrent bacterial skin infections (HP:0005406)2.51059922
64True hermaphroditism (HP:0010459)2.49379848
65Aplasia/Hypoplasia of the patella (HP:0006498)2.49241442
66Abnormality of the fingertips (HP:0001211)2.48680485
67Focal motor seizures (HP:0011153)2.48503365
68Granulocytopenia (HP:0001913)2.47404486
69Rhabdomyosarcoma (HP:0002859)2.46206356
70Erythroderma (HP:0001019)2.43794493
71Congenital ichthyosiform erythroderma (HP:0007431)2.41098561
72Proximal placement of thumb (HP:0009623)2.40969723
73Abnormality of the renal medulla (HP:0100957)2.38812052
74Deviation of the thumb (HP:0009603)2.38521408
75IgG deficiency (HP:0004315)2.33164467
76Abnormality of the labia majora (HP:0012881)2.31182136
77Meckel diverticulum (HP:0002245)2.30033126
78Abnormality of B cell number (HP:0010975)2.27668928
79B lymphocytopenia (HP:0010976)2.27668928
80Furrowed tongue (HP:0000221)2.27364782
81Abnormality of chromosome stability (HP:0003220)2.26329324
82Dehydration (HP:0001944)2.25416903
83Portal hypertension (HP:0001409)2.24510311
84Chromsome breakage (HP:0040012)2.20913893
85Cone-rod dystrophy (HP:0000548)2.20640474
86Abnormality of the ileum (HP:0001549)2.17854372
87Abnormality of the 4th metacarpal (HP:0010012)2.15944586
88Acute lymphatic leukemia (HP:0006721)2.15867161
89Hyperaldosteronism (HP:0000859)2.15157985
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.14870059
91Aplastic anemia (HP:0001915)2.13631132
92Myelodysplasia (HP:0002863)2.13125448
93Nephronophthisis (HP:0000090)2.12923555
94Increased nuchal translucency (HP:0010880)2.12513133
95Emphysema (HP:0002097)2.11066670
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10608150
97Thyroiditis (HP:0100646)2.09931848
98Tubular atrophy (HP:0000092)2.08783975
99Gastrointestinal inflammation (HP:0004386)2.07331446
100Cystic liver disease (HP:0006706)2.06919112
101Mediastinal lymphadenopathy (HP:0100721)2.06227635
102Abnormality of macular pigmentation (HP:0008002)2.05703290
103Chronic diarrhea (HP:0002028)2.05560453
104IgA deficiency (HP:0002720)2.05494550
105Proximal amyotrophy (HP:0007126)2.04696301
106Inflammation of the large intestine (HP:0002037)2.03584790
107Long eyelashes (HP:0000527)2.02873556
108Abnormality of renin-angiotensin system (HP:0000847)2.00673398
109Gangrene (HP:0100758)2.00256607
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.99387685
111Abnormal blistering of the skin (HP:0008066)1.98375814
112Widely spaced teeth (HP:0000687)1.97842602
113Abnormality of the hepatic vasculature (HP:0006707)1.97135069
114Viral hepatitis (HP:0006562)1.96140849
115Leukopenia (HP:0001882)1.95663526
116Corneal erosion (HP:0200020)1.95602053
117Periodontitis (HP:0000704)1.95485499
118Papillary thyroid carcinoma (HP:0002895)1.94848830
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.93378938
120Congenital hepatic fibrosis (HP:0002612)1.93192049
121Popliteal pterygium (HP:0009756)1.92799992
122Chronic sinusitis (HP:0011109)1.92695862
123Basal cell carcinoma (HP:0002671)1.92551033
124Fragile nails (HP:0001808)1.92346574
125Clubbing of toes (HP:0100760)1.91949908
126Abnormality of cells of the erythroid lineage (HP:0012130)1.91833430
127Abnormality of the preputium (HP:0100587)1.91114637
128Stomach cancer (HP:0012126)1.90707922
129Colitis (HP:0002583)1.90591244
130Amaurosis fugax (HP:0100576)1.90585349
131Cutis marmorata (HP:0000965)1.89982273
132Chronic otitis media (HP:0000389)1.89344907
133Woolly hair (HP:0002224)1.88652789
134Abnormality of T cells (HP:0002843)1.87536095
135Recurrent abscess formation (HP:0002722)1.87339276
136Premature graying of hair (HP:0002216)1.87174401
137Aortic regurgitation (HP:0001659)1.85909775
138Bronchitis (HP:0012387)1.84931144
13911 pairs of ribs (HP:0000878)1.84863604
140Abnormality of the renal cortex (HP:0011035)1.84187518
141Lip pit (HP:0100267)1.84052968
142Neoplasm of striated muscle (HP:0009728)1.82861304
143Vasculitis (HP:0002633)1.82553487
144Abnormality of the incisor (HP:0000676)1.82467944
145Selective tooth agenesis (HP:0001592)1.81780754
146Hypoplasia of dental enamel (HP:0006297)1.81767084
147Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.80988046
148Optic nerve coloboma (HP:0000588)1.80545873
149Tubulointerstitial nephritis (HP:0001970)1.80381135
150Increased cerebral lipofuscin (HP:0011813)1.79612678
151Amyloidosis (HP:0011034)1.79495618
152Abnormal lung lobation (HP:0002101)1.78815803
153Palmoplantar keratoderma (HP:0000982)1.77732956
154Autoimmune hemolytic anemia (HP:0001890)1.77361171
155Cutaneous melanoma (HP:0012056)1.77228733
156Osteomyelitis (HP:0002754)1.76636868
157Recurrent otitis media (HP:0000403)1.76153401
158Abnormality of secondary sexual hair (HP:0009888)1.75994533
159Abnormality of the axillary hair (HP:0100134)1.75994533
160Recurrent pneumonia (HP:0006532)1.75663244
161Absent frontal sinuses (HP:0002688)1.75604509
162Renal duplication (HP:0000075)1.74191828
163Molar tooth sign on MRI (HP:0002419)1.74179302
164Abnormality of midbrain morphology (HP:0002418)1.74179302
165Small epiphyses (HP:0010585)1.73850264
166Hepatoblastoma (HP:0002884)1.73509001
167Stomatitis (HP:0010280)1.73469748
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72607597
169Nephroblastoma (Wilms tumor) (HP:0002667)1.71833418
170Abnormality of T cell physiology (HP:0011840)1.71223155
171Pruritus (HP:0000989)1.70415605
172Male infertility (HP:0003251)1.70081991
173Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69263916
174Pustule (HP:0200039)1.69117591
175Nail dystrophy (HP:0008404)1.69110412
176Abnormal number of erythroid precursors (HP:0012131)1.69030038
177Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68975871
178Duodenal stenosis (HP:0100867)1.68782042
179Small intestinal stenosis (HP:0012848)1.68782042
180Hydroxyprolinuria (HP:0003080)1.68761882
181Abnormality of proline metabolism (HP:0010907)1.68761882
182Tented upper lip vermilion (HP:0010804)1.68648219
183Tubulointerstitial fibrosis (HP:0005576)1.68029582
184Elevated erythrocyte sedimentation rate (HP:0003565)1.67632317
185Increased neuronal autofluorescent lipopigment (HP:0002074)1.66790607
186Epidermoid cyst (HP:0200040)1.66788753
187Abnormality of chloride homeostasis (HP:0011422)1.66182147
188Atresia of the external auditory canal (HP:0000413)1.65938636
189Vertebral arch anomaly (HP:0008438)1.65546933
190Bilateral sensorineural hearing impairment (HP:0008619)1.65498136
191Oral leukoplakia (HP:0002745)1.62725378
192Neutropenia (HP:0001875)1.62170900
193Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61766970
194Embryonal renal neoplasm (HP:0011794)1.61202868

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.66937927
2STK38L5.62836992
3MAP4K14.42855083
4LATS24.08985295
5CDC73.14496062
6MST1R3.03145335
7FRK2.86263504
8GRK62.73321157
9MAP3K102.53177333
10IRAK32.49669688
11MKNK12.39871756
12WEE12.38536470
13ACVR1B2.33339028
14MST42.32410291
15MAP3K22.23501158
16EPHA22.17248646
17CDK122.15892191
18SRPK12.13972106
19MAPK151.91367846
20MKNK21.89733011
21MET1.82671139
22TGFBR11.82461316
23VRK11.80826232
24NEK21.79011494
25BTK1.72308528
26CLK11.70983657
27STK381.68127703
28RIPK11.65484455
29DYRK31.60069824
30CSF1R1.59175050
31STK101.58018048
32NLK1.49712678
33KIT1.38346970
34ATR1.37976286
35BRD41.36429268
36LRRK21.35275456
37BUB11.34953884
38EEF2K1.33982809
39BMPR21.33960314
40TGFBR21.29955200
41ERBB31.24855896
42EIF2AK31.23687702
43SYK1.23318735
44TLK11.23134726
45PASK1.21665588
46PLK11.15798150
47IRAK11.15200212
48BRSK21.12822884
49AURKB1.12692590
50PIM11.10927223
51RPS6KB21.10309619
52YES11.06095566
53CCNB11.04891617
54PIK3CG1.04716129
55MARK11.03712530
56TRPM71.02993550
57PRKAA21.01156616
58DYRK20.99996490
59RPS6KA40.99961564
60BRSK10.98847182
61CHEK10.96750217
62TTK0.94846771
63MOS0.94837170
64CDK40.93561701
65EIF2AK10.93336895
66IRAK40.91737413
67BCR0.91603281
68MAP2K20.91455988
69STK240.90187105
70CHEK20.89317928
71GRK70.88970468
72TEC0.88467887
73FER0.87204940
74TAOK30.86771252
75SIK30.86274207
76CDK70.85822353
77SIK20.84440210
78LYN0.84366539
79BLK0.82146189
80TSSK60.82069838
81EPHB20.80331654
82PLK30.78807463
83FGFR30.75635267
84PBK0.75633364
85ATM0.74477890
86MAP3K140.74165216
87STK40.73488316
88PDK20.70675206
89TXK0.70523449
90LCK0.70401869
91JAK30.70001959
92CDK20.69660702
93MAP3K30.69500793
94KSR20.69079860
95ALK0.68994803
96MATK0.68235959
97NEK90.65427910
98CSNK1A1L0.65161093
99MAP3K10.64069590
100TRIM280.63426427
101CSNK1G30.63426169
102LATS10.62361318
103HCK0.61960611
104ADRBK20.61429856
105MAPK130.61156743
106IKBKB0.60447756
107CSK0.59821970
108EPHB10.59735942
109MELK0.58316506
110PDPK10.57165444
111STK30.57075696
112BMPR1B0.56471277
113ITK0.56099764
114DYRK1B0.54707559
115PTK2B0.54701576
116CDK60.54391772
117ADRBK10.54214693
118IRAK20.54144720
119MAP3K80.54040926
120CDK10.52805428
121CHUK0.51138344
122EIF2AK20.50463142
123UHMK10.50039477
124PRKD30.49898627
125ABL10.49561160
126TYK20.49453740
127LMTK20.46977678
128ZAP700.46930839
129PINK10.46399532
130ERBB40.45702410
131MAP3K130.43873028
132MAPK40.42949439
133ILK0.42533292
134DAPK20.42224173
135FLT30.42205603
136RPS6KB10.41439496
137CSNK1G10.40461512
138ZAK0.39808333
139CSNK2A20.39117121
140TESK20.38583628
141MAP2K10.37843049
142EGFR0.37815577
143CAMK1D0.37765437
144CSNK2A10.37369408
145KSR10.36356204
146STK390.35813198
147TBK10.35718261
148MARK30.33728955
149ERBB20.32730959
150RPS6KC10.32273530
151RPS6KL10.32273530
152AKT10.31565486
153RPS6KA60.31070880
154MAP3K120.30202605
155EPHA30.30137341
156PRKCE0.28869261
157MAP3K60.28381392
158MAPK70.27613112
159MAP3K70.25435318
160TAOK10.25192145
161IGF1R0.24956907
162JAK20.23920536
163MAP4K20.23827023
164OBSCN0.23678256
165OXSR10.23514547
166PRKCI0.22197234
167PDGFRB0.21673931
168CAMK1G0.20533255
169FGR0.20070993

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.18501530
2Mismatch repair_Homo sapiens_hsa034303.59930810
3Sphingolipid metabolism_Homo sapiens_hsa006003.24608175
4Spliceosome_Homo sapiens_hsa030402.95726211
5Base excision repair_Homo sapiens_hsa034102.87092428
6Primary immunodeficiency_Homo sapiens_hsa053402.83117511
7Dorso-ventral axis formation_Homo sapiens_hsa043202.60967285
8Cell cycle_Homo sapiens_hsa041102.48406862
9Ribosome_Homo sapiens_hsa030102.44451965
10B cell receptor signaling pathway_Homo sapiens_hsa046622.41697928
11Homologous recombination_Homo sapiens_hsa034402.40345157
12Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.19337324
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.10778048
14Nucleotide excision repair_Homo sapiens_hsa034202.10172122
15RNA transport_Homo sapiens_hsa030132.08642910
16Non-homologous end-joining_Homo sapiens_hsa034502.03381006
17Fanconi anemia pathway_Homo sapiens_hsa034601.95116395
18mRNA surveillance pathway_Homo sapiens_hsa030151.93440675
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92376090
20* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89175647
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83542839
22Histidine metabolism_Homo sapiens_hsa003401.81508311
23Systemic lupus erythematosus_Homo sapiens_hsa053221.64580822
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62751591
25One carbon pool by folate_Homo sapiens_hsa006701.59004403
26RNA degradation_Homo sapiens_hsa030181.55689212
27Antigen processing and presentation_Homo sapiens_hsa046121.45318303
28Phototransduction_Homo sapiens_hsa047441.45032355
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.44769041
30Herpes simplex infection_Homo sapiens_hsa051681.41922109
31MicroRNAs in cancer_Homo sapiens_hsa052061.39957227
32Asthma_Homo sapiens_hsa053101.38897048
33Epstein-Barr virus infection_Homo sapiens_hsa051691.38463179
34Chemical carcinogenesis_Homo sapiens_hsa052041.37918469
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32813638
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32405717
37Pyrimidine metabolism_Homo sapiens_hsa002401.31105617
38Staphylococcus aureus infection_Homo sapiens_hsa051501.28398950
39p53 signaling pathway_Homo sapiens_hsa041151.28350916
40Rheumatoid arthritis_Homo sapiens_hsa053231.26872208
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22843657
42Viral carcinogenesis_Homo sapiens_hsa052031.22671067
43Hematopoietic cell lineage_Homo sapiens_hsa046401.19585078
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.19350907
45Measles_Homo sapiens_hsa051621.18559112
46HTLV-I infection_Homo sapiens_hsa051661.17995079
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15635596
48Notch signaling pathway_Homo sapiens_hsa043301.15084134
49Colorectal cancer_Homo sapiens_hsa052101.14861194
50Pertussis_Homo sapiens_hsa051331.14450397
51Phenylalanine metabolism_Homo sapiens_hsa003601.13866000
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13733674
53Viral myocarditis_Homo sapiens_hsa054161.11920650
54Mineral absorption_Homo sapiens_hsa049781.08923333
55Chronic myeloid leukemia_Homo sapiens_hsa052201.07796079
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05157273
57Graft-versus-host disease_Homo sapiens_hsa053321.05121894
58RNA polymerase_Homo sapiens_hsa030201.03981347
59Retinol metabolism_Homo sapiens_hsa008301.03719527
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03190820
61Proteasome_Homo sapiens_hsa030501.02969314
62Hepatitis B_Homo sapiens_hsa051611.02822346
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02733765
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.01870353
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01378057
66Circadian rhythm_Homo sapiens_hsa047101.01107319
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00924453
68Small cell lung cancer_Homo sapiens_hsa052221.00520764
69T cell receptor signaling pathway_Homo sapiens_hsa046600.98229692
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98028080
71Nitrogen metabolism_Homo sapiens_hsa009100.97607743
72Amoebiasis_Homo sapiens_hsa051460.96221127
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94902716
74Starch and sucrose metabolism_Homo sapiens_hsa005000.93354017
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93163131
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92886076
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92787867
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92527970
79Shigellosis_Homo sapiens_hsa051310.91218496
80Lysosome_Homo sapiens_hsa041420.90620352
81Oocyte meiosis_Homo sapiens_hsa041140.90461580
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90300570
83Leishmaniasis_Homo sapiens_hsa051400.89641516
84African trypanosomiasis_Homo sapiens_hsa051430.89580527
85Basal cell carcinoma_Homo sapiens_hsa052170.89284584
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88908312
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88139372
88Linoleic acid metabolism_Homo sapiens_hsa005910.88032177
89Non-small cell lung cancer_Homo sapiens_hsa052230.87071176
90Sulfur metabolism_Homo sapiens_hsa009200.87023419
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83457210
92Tryptophan metabolism_Homo sapiens_hsa003800.81669021
93Malaria_Homo sapiens_hsa051440.81361867
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.80893409
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80796527
96ABC transporters_Homo sapiens_hsa020100.80684118
97Lysine degradation_Homo sapiens_hsa003100.80632752
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.80484825
99Vitamin digestion and absorption_Homo sapiens_hsa049770.79613195
100Apoptosis_Homo sapiens_hsa042100.78906644
101Osteoclast differentiation_Homo sapiens_hsa043800.78212842
102Alcoholism_Homo sapiens_hsa050340.77955792
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.77916864
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77746049
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.75758201
106Hippo signaling pathway_Homo sapiens_hsa043900.73525726
107VEGF signaling pathway_Homo sapiens_hsa043700.73393497
108Glycerolipid metabolism_Homo sapiens_hsa005610.70563862
109Caffeine metabolism_Homo sapiens_hsa002320.69933510
110Influenza A_Homo sapiens_hsa051640.69880550
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69729526
112Basal transcription factors_Homo sapiens_hsa030220.69312422
113Fatty acid biosynthesis_Homo sapiens_hsa000610.68323756
114Pathways in cancer_Homo sapiens_hsa052000.67023171
115Taste transduction_Homo sapiens_hsa047420.66724094
116Pancreatic cancer_Homo sapiens_hsa052120.66668212
117Allograft rejection_Homo sapiens_hsa053300.65371766
118Type I diabetes mellitus_Homo sapiens_hsa049400.64958007
119Chemokine signaling pathway_Homo sapiens_hsa040620.63348516
120Wnt signaling pathway_Homo sapiens_hsa043100.62851581
121Arachidonic acid metabolism_Homo sapiens_hsa005900.61225181
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60628938
123Acute myeloid leukemia_Homo sapiens_hsa052210.60322746
124Toxoplasmosis_Homo sapiens_hsa051450.59595413
125Platelet activation_Homo sapiens_hsa046110.59543906
126Hepatitis C_Homo sapiens_hsa051600.59050873
127Renal cell carcinoma_Homo sapiens_hsa052110.58819748
128TGF-beta signaling pathway_Homo sapiens_hsa043500.58127975
129Thyroid cancer_Homo sapiens_hsa052160.57344418
130Adherens junction_Homo sapiens_hsa045200.56930124
131Autoimmune thyroid disease_Homo sapiens_hsa053200.56924736
132Ether lipid metabolism_Homo sapiens_hsa005650.56698983
133Endometrial cancer_Homo sapiens_hsa052130.56625507
134Phagosome_Homo sapiens_hsa041450.56556242
135Type II diabetes mellitus_Homo sapiens_hsa049300.55287081
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54715681
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54454220
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.54423813
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53792830
140N-Glycan biosynthesis_Homo sapiens_hsa005100.52502435
141Salivary secretion_Homo sapiens_hsa049700.51607330
142Legionellosis_Homo sapiens_hsa051340.51347508
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51262620
144FoxO signaling pathway_Homo sapiens_hsa040680.51203474
145beta-Alanine metabolism_Homo sapiens_hsa004100.50338846
146Glutathione metabolism_Homo sapiens_hsa004800.50210840
147Prostate cancer_Homo sapiens_hsa052150.49786009
148PPAR signaling pathway_Homo sapiens_hsa033200.49092453
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.48945973
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48904848
151Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48592472
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.46658650
153Ovarian steroidogenesis_Homo sapiens_hsa049130.45808795
154ECM-receptor interaction_Homo sapiens_hsa045120.45250354
155Tuberculosis_Homo sapiens_hsa051520.44964251
156Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44139626
157Proteoglycans in cancer_Homo sapiens_hsa052050.44121394
158Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43458028
159Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43244399
160Purine metabolism_Homo sapiens_hsa002300.42575378
161Glycerophospholipid metabolism_Homo sapiens_hsa005640.41799782
162Salmonella infection_Homo sapiens_hsa051320.40616038
163Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39944215
164Serotonergic synapse_Homo sapiens_hsa047260.39432931
165TNF signaling pathway_Homo sapiens_hsa046680.37087515
166Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35689768
167Hedgehog signaling pathway_Homo sapiens_hsa043400.35672432
168Sphingolipid signaling pathway_Homo sapiens_hsa040710.32203292
169Glioma_Homo sapiens_hsa052140.31538071
170mTOR signaling pathway_Homo sapiens_hsa041500.30854838

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