B3GNT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a beta-1,3-N-acetylglucosaminyltransferase that adds an N-acetylglucosamine moiety to N-acetylgalactosamine-modified serine or threonine. The encoded enzyme is responsible for creating the core 3 structure of O-glycans, which are important components of mucin-type glycoproteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)7.25159899
2omega-hydroxylase P450 pathway (GO:0097267)7.03382961
3N-acetylneuraminate metabolic process (GO:0006054)6.33383480
4neurofilament cytoskeleton organization (GO:0060052)6.13497301
5sequestering of actin monomers (GO:0042989)5.73053693
6regulation of timing of cell differentiation (GO:0048505)5.28926120
7regulation of energy homeostasis (GO:2000505)5.28519912
8RNA destabilization (GO:0050779)5.14201654
9neuronal action potential (GO:0019228)4.88992386
10positive regulation of action potential (GO:0045760)4.68753307
11response to dietary excess (GO:0002021)4.60107727
12regulation of development, heterochronic (GO:0040034)4.56174124
13somite rostral/caudal axis specification (GO:0032525)4.51612917
14membrane tubulation (GO:0097320)4.39867747
15regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.36779537
16positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.36779537
17negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.26200193
18male sex determination (GO:0030238)4.23751944
19regulation of feeding behavior (GO:0060259)4.20292211
20N-acetylglucosamine metabolic process (GO:0006044)4.17199344
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.15267013
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.15267013
23pyrimidine nucleobase catabolic process (GO:0006208)4.12505096
24negative regulation of synaptic transmission, GABAergic (GO:0032229)4.11552931
25alanine transport (GO:0032328)4.11487927
26proline transport (GO:0015824)4.08860567
27regulation of action potential (GO:0098900)4.05813900
28dendritic spine morphogenesis (GO:0060997)4.02938707
29NADH dehydrogenase complex assembly (GO:0010257)4.01102508
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.01102508
31mitochondrial respiratory chain complex I assembly (GO:0032981)4.01102508
32regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.00765562
33positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.00765562
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.96810365
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.93658129
36gap junction assembly (GO:0016264)3.93360673
37sex determination (GO:0007530)3.89174185
38nucleobase catabolic process (GO:0046113)3.88640227
39amino sugar catabolic process (GO:0046348)3.83527242
40lipid translocation (GO:0034204)3.76992747
41phospholipid translocation (GO:0045332)3.76992747
42viral transcription (GO:0019083)3.72761732
43positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.68630656
44fucose catabolic process (GO:0019317)3.65867395
45L-fucose metabolic process (GO:0042354)3.65867395
46L-fucose catabolic process (GO:0042355)3.65867395
47cellular response to electrical stimulus (GO:0071257)3.65062328
48endothelium development (GO:0003158)3.64785066
49glutamate receptor signaling pathway (GO:0007215)3.64764072
50axon ensheathment in central nervous system (GO:0032291)3.63176360
51central nervous system myelination (GO:0022010)3.63176360
52establishment of mitochondrion localization (GO:0051654)3.60285796
53protein complex biogenesis (GO:0070271)3.57490077
54negative regulation of axon extension (GO:0030517)3.55808595
55eating behavior (GO:0042755)3.54513534
56atrial cardiac muscle cell action potential (GO:0086014)3.54009426
57negative regulation of leukocyte chemotaxis (GO:0002689)3.53649277
58regulation of somitogenesis (GO:0014807)3.51861301
59translational termination (GO:0006415)3.49694556
60positive regulation of B cell differentiation (GO:0045579)3.49183480
61regulation of ARF protein signal transduction (GO:0032012)3.46531785
62piRNA metabolic process (GO:0034587)3.43982108
63Notch signaling involved in heart development (GO:0061314)3.41468390
64regulation of meiosis I (GO:0060631)3.40222917
65membrane depolarization during action potential (GO:0086010)3.39674384
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39524405
67negative regulation of vascular permeability (GO:0043116)3.38262102
68sperm capacitation (GO:0048240)3.35174098
69respiratory chain complex IV assembly (GO:0008535)3.34120268
70negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.32181116
71glomerular filtration (GO:0003094)3.31575494
72mitochondrion transport along microtubule (GO:0047497)3.30682433
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.30682433
74detection of light stimulus involved in visual perception (GO:0050908)3.24864917
75detection of light stimulus involved in sensory perception (GO:0050962)3.24864917
76cGMP-mediated signaling (GO:0019934)3.23617356
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.23168496
78myelin maintenance (GO:0043217)3.21386674
79positive regulation of systemic arterial blood pressure (GO:0003084)3.20861540
80vocalization behavior (GO:0071625)3.20188115
81renal filtration (GO:0097205)3.18176125
82calcium ion import (GO:0070509)3.17238276
83response to auditory stimulus (GO:0010996)3.13152413
84androgen biosynthetic process (GO:0006702)3.12319100
85thalamus development (GO:0021794)3.08934306
86neuronal action potential propagation (GO:0019227)3.06705065
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05889073
88negative regulation of phosphatase activity (GO:0010923)3.05532807
89organ growth (GO:0035265)3.05173857
90mitochondrial respiratory chain complex assembly (GO:0033108)3.03452644
91positive regulation of mRNA catabolic process (GO:0061014)3.02678551
92translational elongation (GO:0006414)2.98716526
93sulfate transmembrane transport (GO:1902358)2.95074367
94establishment of protein localization to mitochondrial membrane (GO:0090151)2.93668040
95thyroid gland development (GO:0030878)2.87900132
96locomotory exploration behavior (GO:0035641)2.84746823
97positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.84026730
98dopaminergic neuron differentiation (GO:0071542)2.83512710
99regulation of cardiac muscle cell contraction (GO:0086004)2.82138936
100aorta morphogenesis (GO:0035909)2.82002433
101mannose metabolic process (GO:0006013)2.81288418
102intestinal absorption (GO:0050892)2.80965889
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.79140435
104post-anal tail morphogenesis (GO:0036342)2.77527573
105mitochondrial calcium ion transport (GO:0006851)2.77309688
106cotranslational protein targeting to membrane (GO:0006613)2.77021089
107negative regulation of T cell receptor signaling pathway (GO:0050860)2.76408398
108positive regulation of respiratory burst (GO:0060267)2.75860465
109actin filament depolymerization (GO:0030042)2.75653961
110cytochrome complex assembly (GO:0017004)2.75224033
111cochlea development (GO:0090102)2.74869469
112negative regulation of axon guidance (GO:1902668)2.74798725
113antibacterial humoral response (GO:0019731)2.73306574
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.72599649
115killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.71996954
116disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.71996954
117protein targeting to ER (GO:0045047)2.71358699
118negative regulation of cation channel activity (GO:2001258)2.70857150
119negative regulation of adherens junction organization (GO:1903392)2.70449274
120negative regulation of focal adhesion assembly (GO:0051895)2.70449274
121negative regulation of cell junction assembly (GO:1901889)2.70449274
122viral life cycle (GO:0019058)2.70274518
123cyclic nucleotide catabolic process (GO:0009214)2.69867773
124glucosamine-containing compound metabolic process (GO:1901071)2.68328973
125regulation of voltage-gated calcium channel activity (GO:1901385)2.67447179
126negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.66749703
127heparin biosynthetic process (GO:0030210)2.66405471
128heparin metabolic process (GO:0030202)2.66405471
129regulation of cell communication by electrical coupling (GO:0010649)2.66209488
130gamma-aminobutyric acid signaling pathway (GO:0007214)2.66172314
131negative regulation of dephosphorylation (GO:0035305)2.64859440
132cellular protein complex disassembly (GO:0043624)2.64730748
133cell proliferation in forebrain (GO:0021846)2.64565362
134positive regulation of megakaryocyte differentiation (GO:0045654)2.63679536
135positive regulation of astrocyte differentiation (GO:0048711)2.62825027
136* O-glycan processing (GO:0016266)2.62373025
137cell communication involved in cardiac conduction (GO:0086065)2.61688324
138disruption of cells of other organism (GO:0044364)2.61106872
139killing of cells of other organism (GO:0031640)2.61106872
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59852765
141presynaptic membrane assembly (GO:0097105)2.58069074
142intestinal epithelial cell development (GO:0060576)2.57177153
143negative regulation of heart rate (GO:0010459)2.56916018
144estrogen biosynthetic process (GO:0006703)2.56644034
145negative regulation of T cell differentiation in thymus (GO:0033085)2.56437853
146positive regulation of meiosis (GO:0045836)2.56183069
147positive regulation of mRNA 3-end processing (GO:0031442)2.55835790
148retina layer formation (GO:0010842)2.55016034
149neuromuscular process controlling posture (GO:0050884)2.54140758
150kidney morphogenesis (GO:0060993)2.53950245
151DNA methylation involved in gamete generation (GO:0043046)2.53744892
152maturation of SSU-rRNA (GO:0030490)2.53700402
153long-chain fatty acid biosynthetic process (GO:0042759)2.53215859
154establishment of protein localization to endoplasmic reticulum (GO:0072599)2.52848331
155embryonic digestive tract development (GO:0048566)2.52252485
156negative regulation of calcium ion transmembrane transport (GO:1903170)2.52163548
157negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52163548
158exogenous drug catabolic process (GO:0042738)2.51713591
159entrainment of circadian clock by photoperiod (GO:0043153)2.50909660
160regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50229631
161regulation of integrin activation (GO:0033623)2.48705880
162ventricular trabecula myocardium morphogenesis (GO:0003222)2.47360213
163regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.46602932
164negative regulation of protein localization to cell surface (GO:2000009)2.44021306
165DNA ligation (GO:0006266)2.40228024
166cGMP metabolic process (GO:0046068)2.38316294
167cAMP catabolic process (GO:0006198)2.33885082
168L-amino acid import (GO:0043092)2.33544365
169astrocyte development (GO:0014002)2.33150971
170axon ensheathment (GO:0008366)2.33036972
171ensheathment of neurons (GO:0007272)2.33036972
172positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.32557441
173branching involved in salivary gland morphogenesis (GO:0060445)2.32323586
174adhesion of symbiont to host cell (GO:0044650)2.31078677
175virion attachment to host cell (GO:0019062)2.31078677
176mesodermal cell differentiation (GO:0048333)2.30905022
177mating behavior (GO:0007617)2.30640911
178regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.30474723
179central nervous system neuron axonogenesis (GO:0021955)2.29888701
180sulfate transport (GO:0008272)2.28480707
181presynaptic membrane organization (GO:0097090)2.28334724
182UDP-N-acetylglucosamine metabolic process (GO:0006047)2.28037128
183positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.27464051
184negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.25933338
185synaptic vesicle exocytosis (GO:0016079)2.25775879
186lung-associated mesenchyme development (GO:0060484)2.23326135
187protein localization to endosome (GO:0036010)2.21712058
188labyrinthine layer blood vessel development (GO:0060716)2.21577956
189bile acid and bile salt transport (GO:0015721)2.21404618
190axon development (GO:0061564)2.21159993
191amino sugar metabolic process (GO:0006040)2.20413397
192apical protein localization (GO:0045176)2.20111752
193negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.19862851
194fatty acid elongation (GO:0030497)2.19352737
195action potential (GO:0001508)2.18750403
196asymmetric protein localization (GO:0008105)2.18384097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19627006
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.07251414
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.98624805
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.95724632
5CDX2_20551321_ChIP-Seq_CACO-2_Human2.90126239
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.83961039
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.65726722
8SRY_22984422_ChIP-ChIP_TESTIS_Rat2.61037898
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44348262
10GBX2_23144817_ChIP-Seq_PC3_Human2.43859858
11ZNF274_21170338_ChIP-Seq_K562_Hela2.33796385
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.31928662
13VDR_22108803_ChIP-Seq_LS180_Human2.23138562
14FUS_26573619_Chip-Seq_HEK293_Human2.22734736
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21750945
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19984178
17DROSHA_22980978_ChIP-Seq_HELA_Human2.17533160
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.16449063
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11586774
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11586774
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.10460899
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.08434473
23* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03383774
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.01337932
25GATA1_26923725_Chip-Seq_HPCs_Mouse1.99482176
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98597594
27* REST_21632747_ChIP-Seq_MESCs_Mouse1.94644390
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94272337
29* EZH2_27294783_Chip-Seq_ESCs_Mouse1.84986723
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84961889
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82733723
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.81975539
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81939617
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.77595333
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77138381
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75038297
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.74477188
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74203553
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73442784
40* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71283401
41AR_25329375_ChIP-Seq_VCAP_Human1.69064416
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66993718
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65187819
44* RNF2_27304074_Chip-Seq_ESCs_Mouse1.63810587
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61931415
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61840409
47RNF2_27304074_Chip-Seq_NSC_Mouse1.61330038
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60687475
49* CBP_20019798_ChIP-Seq_JUKART_Human1.60294693
50* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60294693
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59783463
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.58765895
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.58491037
54P300_19829295_ChIP-Seq_ESCs_Human1.57688257
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56896104
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.55641806
57SCL_19346495_ChIP-Seq_HPC-7_Human1.55395104
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52825988
59* PIAS1_25552417_ChIP-Seq_VCAP_Human1.48992832
60* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46065762
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.42972247
62* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41296869
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.39440559
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37638068
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.34462096
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34372439
67EWS_26573619_Chip-Seq_HEK293_Human1.34010033
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33283296
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33283296
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.31475984
71* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30590180
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28559614
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27786018
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27525950
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27407090
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25728393
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25728393
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25728393
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24591818
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24337220
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.23606099
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23083594
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.22148214
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.21234190
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20843294
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19746224
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18739335
88BCAT_22108803_ChIP-Seq_LS180_Human1.18261311
89TAF15_26573619_Chip-Seq_HEK293_Human1.16957633
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.16595206
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16128847
92* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14370756
93RUNX2_22187159_ChIP-Seq_PCA_Human1.14308047
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.13452714
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13409919
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11815217
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11115286
98SOX2_20726797_ChIP-Seq_SW620_Human1.10504783
99* ER_23166858_ChIP-Seq_MCF-7_Human1.10059586
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09836833
101ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09550484
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08887272
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08814358
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08278446
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.07927010
106AR_21572438_ChIP-Seq_LNCaP_Human1.07755192
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07590548
108CBX2_27304074_Chip-Seq_ESCs_Mouse1.06294440
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05643338
110TP53_16413492_ChIP-PET_HCT116_Human1.04195688
111TCF4_23295773_ChIP-Seq_U87_Human1.03968353
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03920125
113STAT3_23295773_ChIP-Seq_U87_Human1.03762760
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03048923
115SMAD3_21741376_ChIP-Seq_HESCs_Human1.02473126
116* KDM2B_26808549_Chip-Seq_K562_Human1.02103951
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01563761
118MYC_18940864_ChIP-ChIP_HL60_Human1.01262848
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00460209
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00154723
121NCOR_22424771_ChIP-Seq_293T_Human0.99961494
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99146305
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99049033
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.98374466
125TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98226485
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96466922
127GATA1_19941826_ChIP-Seq_K562_Human0.95895534
128* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95734339
129TCF4_22108803_ChIP-Seq_LS180_Human0.94922238
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94427642
131TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93842301
132RXR_22108803_ChIP-Seq_LS180_Human0.93719442
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92861146
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91890710
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.91826256
136KLF5_25053715_ChIP-Seq_YYC3_Human0.91496202
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91263473
138RUNX1_27514584_Chip-Seq_MCF-7_Human0.91180152
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90480974
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89639495
141CTCF_27219007_Chip-Seq_Bcells_Human0.89138732
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88643038
143STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87792291
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86769249
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85573567
146SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85376709
147GATA2_19941826_ChIP-Seq_K562_Human0.84237134
148WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.84199414
149RARB_27405468_Chip-Seq_BRAIN_Mouse0.84077363
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82451022
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.80820067
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80736785
153SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79384117
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78847315
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78770669
156RACK7_27058665_Chip-Seq_MCF-7_Human0.78027936
157SMAD4_21799915_ChIP-Seq_A2780_Human0.77435268
158TP53_18474530_ChIP-ChIP_U2OS_Human0.77073929
159OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.76592792
160HTT_18923047_ChIP-ChIP_STHdh_Human0.76534426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis7.98648492
2MP0005623_abnormal_meninges_morphology4.78057651
3MP0002837_dystrophic_cardiac_calcinosis4.10037474
4MP0003136_yellow_coat_color3.86634992
5MP0003866_abnormal_defecation3.27092051
6MP0003880_abnormal_central_pattern3.11341673
7MP0006054_spinal_hemorrhage2.96852451
8MP0005646_abnormal_pituitary_gland2.93025004
9MP0000569_abnormal_digit_pigmentation2.82633625
10MP0005085_abnormal_gallbladder_physiolo2.75065731
11MP0004270_analgesia2.64679495
12MP0005409_darkened_coat_color2.62802668
13MP0003868_abnormal_feces_composition2.48500512
14MP0003279_aneurysm2.40999422
15MP0006292_abnormal_olfactory_placode2.39463903
16MP0005360_urolithiasis2.33318722
17MP0006138_congestive_heart_failure2.18768299
18MP0001666_abnormal_nutrient_absorption2.17630086
19MP0003724_increased_susceptibility_to2.15430587
20MP0001664_abnormal_digestion2.15171408
21MP0003690_abnormal_glial_cell2.09734797
22MP0005165_increased_susceptibility_to2.06400899
23MP0004134_abnormal_chest_morphology2.06367753
24MP0001663_abnormal_digestive_system2.00405948
25MP0008877_abnormal_DNA_methylation1.99611665
26MP0000920_abnormal_myelination1.95869649
27MP0010234_abnormal_vibrissa_follicle1.95407307
28MP0002653_abnormal_ependyma_morphology1.93953900
29MP0004859_abnormal_synaptic_plasticity1.93254117
30MP0000465_gastrointestinal_hemorrhage1.92023703
31MP0003303_peritoneal_inflammation1.87192489
32MP0005666_abnormal_adipose_tissue1.85097768
33MP0005381_digestive/alimentary_phenotyp1.84327402
34MP0005084_abnormal_gallbladder_morpholo1.83525191
35MP0006072_abnormal_retinal_apoptosis1.79350400
36MP0004885_abnormal_endolymph1.78882629
37MP0004185_abnormal_adipocyte_glucose1.78254615
38MP0003567_abnormal_fetal_cardiomyocyte1.72768470
39MP0003075_altered_response_to1.72317789
40MP0004858_abnormal_nervous_system1.70887807
41MP0005167_abnormal_blood-brain_barrier1.67826309
42MP0004043_abnormal_pH_regulation1.65395477
43MP0009379_abnormal_foot_pigmentation1.63786811
44MP0008995_early_reproductive_senescence1.62993223
45MP0003890_abnormal_embryonic-extraembry1.62685626
46MP0001764_abnormal_homeostasis1.59193436
47MP0001968_abnormal_touch/_nociception1.55786394
48MP0000049_abnormal_middle_ear1.55147665
49MP0002876_abnormal_thyroid_physiology1.54852864
50MP0001440_abnormal_grooming_behavior1.53909807
51MP0002102_abnormal_ear_morphology1.51590855
52MP0009745_abnormal_behavioral_response1.51248754
53MP0004510_myositis1.50487191
54MP0003635_abnormal_synaptic_transmissio1.49821483
55MP0004272_abnormal_basement_membrane1.49681416
56MP0002139_abnormal_hepatobiliary_system1.49232270
57MP0001486_abnormal_startle_reflex1.47186885
58MP0001986_abnormal_taste_sensitivity1.45700982
59MP0003252_abnormal_bile_duct1.45335067
60MP0000534_abnormal_ureter_morphology1.43359968
61MP0000462_abnormal_digestive_system1.40564368
62MP0000767_abnormal_smooth_muscle1.36934906
63MP0009780_abnormal_chondrocyte_physiolo1.36284774
64MP0002272_abnormal_nervous_system1.34026293
65MP0002735_abnormal_chemical_nociception1.33311014
66MP0000490_abnormal_crypts_of1.33262424
67MP0002282_abnormal_trachea_morphology1.26547923
68MP0005365_abnormal_bile_salt1.26486659
69MP0002277_abnormal_respiratory_mucosa1.26474976
70MP0002064_seizures1.25340218
71MP0003938_abnormal_ear_development1.24937850
72MP0002928_abnormal_bile_duct1.24021632
73MP0003806_abnormal_nucleotide_metabolis1.23957804
74MP0005375_adipose_tissue_phenotype1.23128196
75MP0001485_abnormal_pinna_reflex1.22927405
76MP0003633_abnormal_nervous_system1.18867667
77MP0005386_behavior/neurological_phenoty1.15917564
78MP0004924_abnormal_behavior1.15917564
79MP0000477_abnormal_intestine_morphology1.15800980
80MP0002638_abnormal_pupillary_reflex1.14477501
81MP0003195_calcinosis1.13994001
82MP0005174_abnormal_tail_pigmentation1.13667647
83MP0010155_abnormal_intestine_physiology1.13465209
84MP0000778_abnormal_nervous_system1.12843471
85MP0001765_abnormal_ion_homeostasis1.11686173
86MP0004215_abnormal_myocardial_fiber1.10961075
87MP0006276_abnormal_autonomic_nervous1.10484383
88MP0010329_abnormal_lipoprotein_level1.10458166
89MP0003693_abnormal_embryo_hatching1.08349842
90MP0004130_abnormal_muscle_cell1.06195062
91MP0000467_abnormal_esophagus_morphology1.05925338
92MP0005595_abnormal_vascular_smooth1.04848037
93MP0005171_absent_coat_pigmentation1.02436500
94MP0004147_increased_porphyrin_level1.00309348
95MP0003283_abnormal_digestive_organ0.99062587
96MP0003755_abnormal_palate_morphology0.96326126
97MP0001970_abnormal_pain_threshold0.96276647
98MP0002734_abnormal_mechanical_nocicepti0.95576996
99MP0008875_abnormal_xenobiotic_pharmacok0.94421455
100MP0001544_abnormal_cardiovascular_syste0.94213251
101MP0005385_cardiovascular_system_phenoty0.94213251
102MP0004145_abnormal_muscle_electrophysio0.93792408
103MP0002822_catalepsy0.93186357
104MP0004142_abnormal_muscle_tone0.92467916
105MP0000026_abnormal_inner_ear0.92226507
106MP0009046_muscle_twitch0.91082581
107MP0008569_lethality_at_weaning0.90411348
108MP0002733_abnormal_thermal_nociception0.90045400
109MP0004782_abnormal_surfactant_physiolog0.87975350
110MP0000955_abnormal_spinal_cord0.87373013
111MP0008872_abnormal_physiological_respon0.86808718
112MP0004264_abnormal_extraembryonic_tissu0.86614953
113MP0001177_atelectasis0.82007584
114MP0003122_maternal_imprinting0.81961460
115MP0002067_abnormal_sensory_capabilities0.81888974
116MP0002751_abnormal_autonomic_nervous0.81831874
117MP0000230_abnormal_systemic_arterial0.80108355
118MP0002938_white_spotting0.79740148
119MP0003878_abnormal_ear_physiology0.79207036
120MP0005377_hearing/vestibular/ear_phenot0.79207036
121MP0002229_neurodegeneration0.78413107
122MP0005423_abnormal_somatic_nervous0.78309885
123MP0000681_abnormal_thyroid_gland0.78286243
124MP0002163_abnormal_gland_morphology0.77386003
125MP0001963_abnormal_hearing_physiology0.77356877
126MP0008874_decreased_physiological_sensi0.76586077
127MP0002557_abnormal_social/conspecific_i0.76497327
128MP0004742_abnormal_vestibular_system0.76459793
129MP0001529_abnormal_vocalization0.75830797
130MP0008775_abnormal_heart_ventricle0.73968927
131MP0004811_abnormal_neuron_physiology0.73434113
132MP0003634_abnormal_glial_cell0.72906585
133MP0004133_heterotaxia0.72869423
134MP0001501_abnormal_sleep_pattern0.72418355
135MP0005253_abnormal_eye_physiology0.72346415
136MP0002932_abnormal_joint_morphology0.71471540
137MP0003631_nervous_system_phenotype0.70805491
138MP0002063_abnormal_learning/memory/cond0.70710052
139MP0001293_anophthalmia0.70257336
140MP0005551_abnormal_eye_electrophysiolog0.70135463
141MP0002736_abnormal_nociception_after0.69627687
142MP0005448_abnormal_energy_balance0.69306454
143MP0002882_abnormal_neuron_morphology0.67663194
144MP0003137_abnormal_impulse_conducting0.67154337
145MP0001756_abnormal_urination0.67059249
146MP0000631_abnormal_neuroendocrine_gland0.66848438
147MP0002160_abnormal_reproductive_system0.66039565
148MP0000639_abnormal_adrenal_gland0.65606201
149MP0000013_abnormal_adipose_tissue0.65418898
150MP0002572_abnormal_emotion/affect_behav0.65083344
151MP0005410_abnormal_fertilization0.62991375
152MP0001984_abnormal_olfaction0.62759357
153MP0003011_delayed_dark_adaptation0.62757498
154MP0001340_abnormal_eyelid_morphology0.60208139
155MP0004019_abnormal_vitamin_homeostasis0.58778658
156MP0005389_reproductive_system_phenotype0.58769784
157MP0003121_genomic_imprinting0.58045850
158MP0002210_abnormal_sex_determination0.56776227

Predicted human phenotypes

RankGene SetZ-score
1Humeroradial synostosis (HP:0003041)5.65950706
2Synostosis involving the elbow (HP:0003938)5.65950706
3Bradycardia (HP:0001662)5.63422301
4Metabolic alkalosis (HP:0200114)5.28194352
5Hypothermia (HP:0002045)4.88021638
6Atonic seizures (HP:0010819)4.65701125
7Hypercortisolism (HP:0001578)4.65668008
8Symphalangism affecting the phalanges of the hand (HP:0009773)4.53404883
9Agitation (HP:0000713)4.52704134
10Degeneration of the lateral corticospinal tracts (HP:0002314)4.31027427
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.31027427
12Acute encephalopathy (HP:0006846)4.20991912
13Follicular hyperkeratosis (HP:0007502)4.06630436
14Inability to walk (HP:0002540)4.01144831
15Septo-optic dysplasia (HP:0100842)3.82191250
16Sensory axonal neuropathy (HP:0003390)3.79471079
17Acute necrotizing encephalopathy (HP:0006965)3.73672400
18Hyperactive renin-angiotensin system (HP:0000841)3.69161472
19Bundle branch block (HP:0011710)3.60086766
20Atrial fibrillation (HP:0005110)3.45605090
21Abnormality of the corticospinal tract (HP:0002492)3.44801013
22Congenital stationary night blindness (HP:0007642)3.40172327
23Hyperglycinemia (HP:0002154)3.36597835
24Adrenal overactivity (HP:0002717)3.34256186
25Malnutrition (HP:0004395)3.32765283
26Optic nerve hypoplasia (HP:0000609)3.31709831
27Absence seizures (HP:0002121)3.31143722
28Ileus (HP:0002595)3.26881130
29Febrile seizures (HP:0002373)3.25183948
30Abnormal number of erythroid precursors (HP:0012131)3.24404827
31Progressive external ophthalmoplegia (HP:0000590)3.22240653
32Abnormal mitochondria in muscle tissue (HP:0008316)3.17720627
33Onion bulb formation (HP:0003383)3.14880862
34Progressive macrocephaly (HP:0004481)3.13106088
35Neoplasm of the heart (HP:0100544)3.12638590
36Congenital, generalized hypertrichosis (HP:0004540)3.10997038
37Abnormality of cells of the erythroid lineage (HP:0012130)3.10914485
38Hyperglycinuria (HP:0003108)3.10323972
39Primary atrial arrhythmia (HP:0001692)3.07944972
40Action tremor (HP:0002345)3.05550252
41Ankyloglossia (HP:0010296)3.01263438
42Dialeptic seizures (HP:0011146)3.00361104
43Gonadotropin excess (HP:0000837)2.99604832
44Amblyopia (HP:0000646)2.99296165
45Supraventricular tachycardia (HP:0004755)2.92577144
46Progressive inability to walk (HP:0002505)2.90843139
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.89879599
48Ankle clonus (HP:0011448)2.88128116
49Partial duplication of thumb phalanx (HP:0009944)2.88119761
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.86370468
51Bilateral microphthalmos (HP:0007633)2.84612139
52Supraventricular arrhythmia (HP:0005115)2.83329425
53Decreased circulating renin level (HP:0003351)2.82982692
54Limb dystonia (HP:0002451)2.82306004
55Alkalosis (HP:0001948)2.78086333
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77016808
57Exertional dyspnea (HP:0002875)2.71487736
58Absent septum pellucidum (HP:0001331)2.69985255
59Focal motor seizures (HP:0011153)2.67732607
60Mitochondrial inheritance (HP:0001427)2.61545372
61Myokymia (HP:0002411)2.59993272
62Partial duplication of the phalanx of hand (HP:0009999)2.59486614
63Chronic hepatic failure (HP:0100626)2.58799816
64Cerebral hemorrhage (HP:0001342)2.57613117
65Abdominal distention (HP:0003270)2.52732932
66Insidious onset (HP:0003587)2.52284168
67Termporal pattern (HP:0011008)2.52284168
68Hyperparathyroidism (HP:0000843)2.52223684
69Spontaneous abortion (HP:0005268)2.51153627
70Gaze-evoked nystagmus (HP:0000640)2.50965779
71Abnormal respiratory motile cilium physiology (HP:0012261)2.49431161
72Steppage gait (HP:0003376)2.47318095
73Delayed CNS myelination (HP:0002188)2.45968807
74Truncal ataxia (HP:0002078)2.40823408
75Epileptic encephalopathy (HP:0200134)2.40210482
76Abnormal ciliary motility (HP:0012262)2.40053447
77Syncope (HP:0001279)2.39930148
78Limb hypertonia (HP:0002509)2.36890561
79Abnormality of serine family amino acid metabolism (HP:0010894)2.36046823
80Abnormality of glycine metabolism (HP:0010895)2.36046823
81Anxiety (HP:0000739)2.33660762
82Abnormality of chloride homeostasis (HP:0011422)2.33552240
83Premature ovarian failure (HP:0008209)2.32787701
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.32248574
85Absent/shortened dynein arms (HP:0200106)2.32248574
86Breast hypoplasia (HP:0003187)2.32009988
87Gastrointestinal dysmotility (HP:0002579)2.28299019
88Restlessness (HP:0000711)2.26925749
89Chin dimple (HP:0010751)2.25234631
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24158381
91External ophthalmoplegia (HP:0000544)2.23478379
92Polycythemia (HP:0001901)2.23020478
93Concave nail (HP:0001598)2.22880925
94Abnormal respiratory motile cilium morphology (HP:0005938)2.22870061
95Abnormal respiratory epithelium morphology (HP:0012253)2.22870061
96Leukodystrophy (HP:0002415)2.19198758
97Short hallux (HP:0010109)2.19096725
98Optic disc pallor (HP:0000543)2.15408672
99Anophthalmia (HP:0000528)2.13693574
100Segmental peripheral demyelination/remyelination (HP:0003481)2.12863718
101Abnormality of pyrimidine metabolism (HP:0004353)2.12819517
102Abnormality of magnesium homeostasis (HP:0004921)2.12261980
103Esophageal atresia (HP:0002032)2.11670247
104Rhinitis (HP:0012384)2.11089040
105Fat malabsorption (HP:0002630)2.10736340
106Pancreatic cysts (HP:0001737)2.10345960
107Hypomagnesemia (HP:0002917)2.09602594
108Striae distensae (HP:0001065)2.08503768
109Abnormality of renin-angiotensin system (HP:0000847)2.07769156
110Dysdiadochokinesis (HP:0002075)2.07332220
111True hermaphroditism (HP:0010459)2.07316431
112Anosmia (HP:0000458)2.05181782
113Heart block (HP:0012722)2.03189745
114Hyperaldosteronism (HP:0000859)2.02844365
115Focal segmental glomerulosclerosis (HP:0000097)2.02143153
116Cupped ear (HP:0000378)2.00218096
117Reticulocytopenia (HP:0001896)1.99742901
118Hepatocellular necrosis (HP:0001404)1.99737510
119Broad metatarsal (HP:0001783)1.99689117
120Palpebral edema (HP:0100540)1.99612062
121Depression (HP:0000716)1.99170531
122Synostosis involving bones of the feet (HP:0009140)1.98068398
123Synostosis involving bones of the lower limbs (HP:0009138)1.98068398
124Palpitations (HP:0001962)1.98065696
125Abnormal atrioventricular conduction (HP:0005150)1.97076162
126Ventricular fibrillation (HP:0001663)1.97072722
127Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97014236
128Hypoplasia of the uterus (HP:0000013)1.96681933
129Cerebral edema (HP:0002181)1.96396609
130Abnormality of the lower motor neuron (HP:0002366)1.95364320
131Stridor (HP:0010307)1.95313260
132Prolonged partial thromboplastin time (HP:0003645)1.94080231
133Abnormality of oral frenula (HP:0000190)1.94001969
134Woolly hair (HP:0002224)1.93837102
135Large for gestational age (HP:0001520)1.92970699
136Azoospermia (HP:0000027)1.92747548
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.92317823
138Hydroxyprolinuria (HP:0003080)1.92234079
139Abnormality of proline metabolism (HP:0010907)1.92234079
140Hypokalemic alkalosis (HP:0001949)1.91152414
141Neurofibrillary tangles (HP:0002185)1.91020489
142Pustule (HP:0200039)1.90717011
143Turricephaly (HP:0000262)1.90387246
144Parakeratosis (HP:0001036)1.89641309
145Neonatal onset (HP:0003623)1.89407272
146Microretrognathia (HP:0000308)1.88301069
147Abnormality of the septum pellucidum (HP:0007375)1.86680179
148Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.86444912
149Spastic paraplegia (HP:0001258)1.85966906
150Birth length less than 3rd percentile (HP:0003561)1.85166413
151Increased circulating renin level (HP:0000848)1.84838178
152Focal seizures (HP:0007359)1.84168918
153Spinal muscular atrophy (HP:0007269)1.84154452
154Ulnar claw (HP:0001178)1.83774607
155Increased CSF lactate (HP:0002490)1.83571643
156Pulmonary artery stenosis (HP:0004415)1.83483148
157Abnormal tarsal ossification (HP:0008369)1.83200287
158Mildly elevated creatine phosphokinase (HP:0008180)1.82203542
159Resting tremor (HP:0002322)1.82158519
160Congenital glaucoma (HP:0001087)1.80703848
161Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80676969
162Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.80655262
163Limb ataxia (HP:0002070)1.80535137
164Tachypnea (HP:0002789)1.80023922
165Lower limb hyperreflexia (HP:0002395)1.79525136
166Synostosis involving bones of the hand (HP:0004278)1.79404390
167Horizontal nystagmus (HP:0000666)1.78776640
168Aplasia/hypoplasia of the uterus (HP:0008684)1.77621097
169Decreased motor nerve conduction velocity (HP:0003431)1.77611411
170Dyskinesia (HP:0100660)1.77130956
171Generalized tonic-clonic seizures (HP:0002069)1.76578086
172Chronic bronchitis (HP:0004469)1.74973524
173Slow saccadic eye movements (HP:0000514)1.72365822
174Macrocytic anemia (HP:0001972)1.69936532
175Hemiplegia (HP:0002301)1.69799639
176Fatigue (HP:0012378)1.67525188
177Prolonged bleeding time (HP:0003010)1.67343093
178Impaired social interactions (HP:0000735)1.67342629
179Abnormal social behavior (HP:0012433)1.67342629
180Peritonitis (HP:0002586)1.65262517
181Upper limb muscle weakness (HP:0003484)1.65163697
182Stomatitis (HP:0010280)1.65095075
183Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.64955588
184Myocardial infarction (HP:0001658)1.64938168
185Abnormality of the 1st metacarpal (HP:0010009)1.63428944
186Progressive cerebellar ataxia (HP:0002073)1.61779939
187Hypoplastic nipples (HP:0002557)1.60553675
188Glomerulosclerosis (HP:0000096)1.60258703

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.17214362
2SIK25.04619336
3PASK4.59535772
4FRK4.30542097
5TNIK3.54525294
6MAPKAPK32.89886842
7TAOK32.75007135
8STK392.74074558
9MYLK2.69554554
10MKNK22.65586188
11FES2.46538905
12TYRO32.44277957
13MAPK132.33842019
14TNK22.23421813
15MST1R2.20902870
16WNK42.10927596
17MAP3K22.10111084
18BMPR1B2.05870397
19RIPK11.99774190
20CAMKK11.98198045
21WNK31.93422754
22TXK1.91849593
23PAK61.85997876
24DMPK1.84271145
25MAPK121.83696208
26ACVR1B1.82785731
27PNCK1.80474701
28EPHB11.73840251
29FGR1.73470516
30UHMK11.63766553
31GRK11.54836777
32NTRK11.53267734
33DYRK21.53194149
34MAPK151.52562182
35MAP2K21.51569801
36PAK31.46319951
37MKNK11.45605974
38KSR21.45364312
39ADRBK21.44190803
40OXSR11.39830679
41CAMKK21.36951881
42KSR11.36592094
43CAMK11.33511474
44BMX1.32687536
45PAK21.31690477
46TRPM71.29552487
47KIT1.27628331
48LRRK21.27528221
49MAPK111.27090723
50CDK31.26620397
51TGFBR11.24908140
52TESK21.24638546
53MAPKAPK51.22458883
54MAPK71.22184228
55LMTK21.18117928
56MST41.15546984
57MET1.13975836
58EPHA41.12244302
59PRKCG1.10712974
60MAP3K71.10439009
61NME11.08952904
62CSK1.08008741
63TEC1.06500787
64ERBB21.03451672
65MAP4K21.03178055
66BRSK21.02515197
67PRKG21.01206299
68ROCK20.99062493
69PKN10.97254283
70INSRR0.95672698
71FGFR20.94435030
72MATK0.93108489
73RAF10.88951801
74STK160.88458576
75PTK60.88338886
76ALK0.85862113
77EPHB20.82342855
78HIPK20.82243201
79MAPK40.79418302
80GRK60.78663287
81RET0.77935306
82STK100.77198379
83DDR20.73150784
84ZAP700.73028471
85ROCK10.73022865
86CDK60.72343250
87MUSK0.70523590
88WEE10.70508475
89NLK0.69068160
90DAPK30.68851827
91MAP3K90.68053221
92ITK0.66386422
93PHKG20.64477520
94PHKG10.64477520
95CAMK2B0.64381086
96MINK10.63816751
97PINK10.62898470
98WNK10.62646204
99MARK30.60563193
100PRKCQ0.60207926
101TRIM280.60070034
102MAP3K40.59639786
103MAP2K10.59404995
104STK110.58866288
105TLK10.56603951
106CAMK1D0.56319027
107CAMK2D0.55783199
108CASK0.55613181
109TSSK60.55519931
110NTRK30.53144257
111FER0.53087836
112CSNK1G10.52636972
113PTK20.52175923
114CSNK1A10.51244305
115RIPK40.50310869
116CDK50.50302588
117PDK10.49110971
118GRK70.49070960
119CAMK2A0.48384925
120CDK140.47696391
121OBSCN0.47404261
122VRK10.46568863
123FYN0.46388612
124MAP3K80.46273845
125LATS20.45872020
126PRKCA0.44911702
127PRKCE0.44870774
128PIK3CG0.43840669
129GRK50.42687544
130ZAK0.42676543
131NEK20.42595287
132TIE10.42495810
133MAP4K10.42348390
134PRKACG0.41263934
135CSNK1E0.41115227
136PRKG10.40122194
137ARAF0.39999567
138SGK2230.39991721
139SGK4940.39991721
140CAMK2G0.39919573
141EEF2K0.39364018
142NTRK20.39063006
143MAP2K60.37783036
144PRKCZ0.37283930
145MAP2K70.36788294
146MARK10.36467429
147SYK0.36395819
148PRKACB0.35792224
149PRKACA0.35770263
150ADRBK10.35351413
151PIK3CA0.33723057
152PIM20.33561127
153DAPK20.33399008
154SGK10.32792917
155MAP3K130.32093333
156DYRK1A0.31855263
157ERBB30.31852373
158ABL20.29687650
159IKBKB0.28492126
160PLK40.28181474
161DAPK10.28060666
162INSR0.26349001
163CHUK0.24750069
164IGF1R0.24672116
165CSNK1G20.23439891
166EPHA20.22765187
167ABL10.22667104

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.87331105
2Ribosome_Homo sapiens_hsa030103.79894291
3Nicotine addiction_Homo sapiens_hsa050333.45470022
4* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.01569834
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84546651
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.80656083
7Taste transduction_Homo sapiens_hsa047422.66912536
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.35610974
9Mineral absorption_Homo sapiens_hsa049782.31458755
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25952317
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.22574928
12Oxidative phosphorylation_Homo sapiens_hsa001902.03765675
13Fatty acid elongation_Homo sapiens_hsa000622.03330984
14Bile secretion_Homo sapiens_hsa049762.02708376
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.91860450
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91759808
17Chemical carcinogenesis_Homo sapiens_hsa052041.76665040
18Salivary secretion_Homo sapiens_hsa049701.72565550
19Parkinsons disease_Homo sapiens_hsa050121.66601875
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64954190
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.60816367
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.60211237
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58126086
24Renin secretion_Homo sapiens_hsa049241.53513508
25Retinol metabolism_Homo sapiens_hsa008301.52410737
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43408265
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41236270
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.38941958
29Fat digestion and absorption_Homo sapiens_hsa049751.37372085
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36527358
31Tyrosine metabolism_Homo sapiens_hsa003501.33845931
32Morphine addiction_Homo sapiens_hsa050321.31104102
33Glutamatergic synapse_Homo sapiens_hsa047241.30332798
34Arachidonic acid metabolism_Homo sapiens_hsa005901.29697763
35Asthma_Homo sapiens_hsa053101.26925441
36Ovarian steroidogenesis_Homo sapiens_hsa049131.24644564
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.22544072
38Tight junction_Homo sapiens_hsa045301.22319989
39Circadian entrainment_Homo sapiens_hsa047131.19511039
40Gastric acid secretion_Homo sapiens_hsa049711.19119426
41Tryptophan metabolism_Homo sapiens_hsa003801.18454852
42Histidine metabolism_Homo sapiens_hsa003401.17885457
43GABAergic synapse_Homo sapiens_hsa047271.16927619
44Gap junction_Homo sapiens_hsa045401.16858378
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16398150
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13358709
47Pancreatic secretion_Homo sapiens_hsa049721.12335122
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10756843
49Long-term depression_Homo sapiens_hsa047301.10501834
50Propanoate metabolism_Homo sapiens_hsa006401.09844554
51Cardiac muscle contraction_Homo sapiens_hsa042601.03309247
52Regulation of autophagy_Homo sapiens_hsa041400.98878356
53Amoebiasis_Homo sapiens_hsa051460.98156194
54Oxytocin signaling pathway_Homo sapiens_hsa049210.97600984
55Butanoate metabolism_Homo sapiens_hsa006500.95468478
56Arginine biosynthesis_Homo sapiens_hsa002200.95357061
57Arginine and proline metabolism_Homo sapiens_hsa003300.94680249
58Protein digestion and absorption_Homo sapiens_hsa049740.94388132
59Axon guidance_Homo sapiens_hsa043600.94336367
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93167453
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92374258
62Platelet activation_Homo sapiens_hsa046110.91472802
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91388105
64Type I diabetes mellitus_Homo sapiens_hsa049400.91237316
65Cholinergic synapse_Homo sapiens_hsa047250.91055618
66Nitrogen metabolism_Homo sapiens_hsa009100.89484935
67Huntingtons disease_Homo sapiens_hsa050160.88977807
68Caffeine metabolism_Homo sapiens_hsa002320.87748907
69Ether lipid metabolism_Homo sapiens_hsa005650.85947188
70Phototransduction_Homo sapiens_hsa047440.85608068
71Dopaminergic synapse_Homo sapiens_hsa047280.85121966
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83892480
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82788005
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81996196
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81964968
76ABC transporters_Homo sapiens_hsa020100.80621775
77Graft-versus-host disease_Homo sapiens_hsa053320.80374199
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78912628
79Renin-angiotensin system_Homo sapiens_hsa046140.78514947
80Autoimmune thyroid disease_Homo sapiens_hsa053200.78051863
81GnRH signaling pathway_Homo sapiens_hsa049120.77271465
82Insulin secretion_Homo sapiens_hsa049110.76476700
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75310556
84Linoleic acid metabolism_Homo sapiens_hsa005910.75237261
85RNA degradation_Homo sapiens_hsa030180.74951453
86Thyroid hormone synthesis_Homo sapiens_hsa049180.73550540
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73176699
88Cocaine addiction_Homo sapiens_hsa050300.73155627
89Fatty acid degradation_Homo sapiens_hsa000710.72331940
90Allograft rejection_Homo sapiens_hsa053300.71351692
91Long-term potentiation_Homo sapiens_hsa047200.71079420
92Dorso-ventral axis formation_Homo sapiens_hsa043200.70467369
93Serotonergic synapse_Homo sapiens_hsa047260.67346555
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65211169
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65092370
96Amphetamine addiction_Homo sapiens_hsa050310.62029704
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61272395
98Focal adhesion_Homo sapiens_hsa045100.60981479
99Fatty acid metabolism_Homo sapiens_hsa012120.60641142
100Sphingolipid metabolism_Homo sapiens_hsa006000.59670910
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.59006673
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58311048
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58230514
104Phenylalanine metabolism_Homo sapiens_hsa003600.56828076
105Peroxisome_Homo sapiens_hsa041460.55875262
106Purine metabolism_Homo sapiens_hsa002300.55793070
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55086185
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54741420
109Melanogenesis_Homo sapiens_hsa049160.54684314
110Dilated cardiomyopathy_Homo sapiens_hsa054140.54414448
111Starch and sucrose metabolism_Homo sapiens_hsa005000.54163932
112beta-Alanine metabolism_Homo sapiens_hsa004100.53368533
113RNA polymerase_Homo sapiens_hsa030200.52799742
114Calcium signaling pathway_Homo sapiens_hsa040200.52748567
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52373283
116Glycerolipid metabolism_Homo sapiens_hsa005610.51977208
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.51043577
118Basal cell carcinoma_Homo sapiens_hsa052170.50787115
119Staphylococcus aureus infection_Homo sapiens_hsa051500.48944823
120Olfactory transduction_Homo sapiens_hsa047400.48692807
121Glutathione metabolism_Homo sapiens_hsa004800.47865330
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46299721
123Rap1 signaling pathway_Homo sapiens_hsa040150.46067209
124Melanoma_Homo sapiens_hsa052180.45812551
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45758578
126Protein export_Homo sapiens_hsa030600.45732044
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44954585
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.44299403
129Complement and coagulation cascades_Homo sapiens_hsa046100.43695764
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43606798
131ECM-receptor interaction_Homo sapiens_hsa045120.43310591
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42703562
133Rheumatoid arthritis_Homo sapiens_hsa053230.42467663
134Synaptic vesicle cycle_Homo sapiens_hsa047210.42464290
135Systemic lupus erythematosus_Homo sapiens_hsa053220.42193816
136Vitamin digestion and absorption_Homo sapiens_hsa049770.42070068
137cAMP signaling pathway_Homo sapiens_hsa040240.41700429
138PPAR signaling pathway_Homo sapiens_hsa033200.40750683
139Alzheimers disease_Homo sapiens_hsa050100.40429669
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39885444
141Antigen processing and presentation_Homo sapiens_hsa046120.37768609
142Fanconi anemia pathway_Homo sapiens_hsa034600.37225590
143* Metabolic pathways_Homo sapiens_hsa011000.36098140
144Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35497247

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »