B4GALNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.54982011
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.46780462
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.46780462
4synaptic vesicle docking involved in exocytosis (GO:0016081)7.08767633
5antigen processing and presentation of endogenous antigen (GO:0019883)6.90951570
6glutamate secretion (GO:0014047)6.56371595
7negative thymic T cell selection (GO:0045060)6.28940933
8positive regulation of gamma-delta T cell activation (GO:0046645)6.28008750
9regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24230110
10negative T cell selection (GO:0043383)6.22779059
11synaptic vesicle exocytosis (GO:0016079)6.10206871
12positive thymic T cell selection (GO:0045059)5.96786241
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.91146605
14negative regulation of cell killing (GO:0031342)5.91146605
15regulation of synaptic vesicle exocytosis (GO:2000300)5.88361559
16regulation of gamma-delta T cell differentiation (GO:0045586)5.35925739
17thymic T cell selection (GO:0045061)5.33270848
18neurotransmitter secretion (GO:0007269)5.31868436
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.29027375
20leukocyte aggregation (GO:0070486)5.26415285
21cellular potassium ion homeostasis (GO:0030007)5.08873002
22positive T cell selection (GO:0043368)5.05313130
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.03628380
24regulation of synaptic vesicle transport (GO:1902803)5.00116635
25positive regulation of synapse maturation (GO:0090129)4.99577625
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96909950
27response to interleukin-15 (GO:0070672)4.84439863
28gamma-aminobutyric acid transport (GO:0015812)4.83529415
29locomotory exploration behavior (GO:0035641)4.80532923
30T cell migration (GO:0072678)4.79297522
31regulation of gamma-delta T cell activation (GO:0046643)4.77714124
32T cell selection (GO:0045058)4.69791906
33sodium ion export (GO:0071436)4.68972579
34layer formation in cerebral cortex (GO:0021819)4.68782710
35regulation of B cell receptor signaling pathway (GO:0050855)4.68370194
36vocalization behavior (GO:0071625)4.65831558
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63699220
38ionotropic glutamate receptor signaling pathway (GO:0035235)4.56372852
39postsynaptic membrane organization (GO:0001941)4.49624427
40cerebellar granule cell differentiation (GO:0021707)4.49142596
41protein localization to synapse (GO:0035418)4.46995823
42negative regulation of synaptic transmission, GABAergic (GO:0032229)4.43352517
43cellular response to interleukin-15 (GO:0071350)4.37598503
44regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.35111661
45neuron cell-cell adhesion (GO:0007158)4.32025086
46cell migration in hindbrain (GO:0021535)4.29504483
47regulation of neuronal synaptic plasticity (GO:0048168)4.26511372
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.24158453
49Arp2/3 complex-mediated actin nucleation (GO:0034314)4.22867652
50interferon-gamma production (GO:0032609)4.22804277
51neuronal action potential propagation (GO:0019227)4.18546442
52exploration behavior (GO:0035640)4.17252860
53regulation of interleukin-12 biosynthetic process (GO:0045075)4.16348029
54regulation of isotype switching to IgG isotypes (GO:0048302)4.14273101
55establishment of mitochondrion localization (GO:0051654)4.12929014
56synaptic transmission, glutamatergic (GO:0035249)4.07105776
57neurotransmitter transport (GO:0006836)4.06801988
58T cell costimulation (GO:0031295)3.98752802
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.98358575
60synaptic vesicle endocytosis (GO:0048488)3.93777299
61T cell receptor signaling pathway (GO:0050852)3.92510740
62lymphocyte costimulation (GO:0031294)3.91343931
63regulation of T cell tolerance induction (GO:0002664)3.90885007
64antigen processing and presentation via MHC class Ib (GO:0002475)3.88156772
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.87159037
66pyrimidine nucleobase catabolic process (GO:0006208)3.85228490
67regulation of synapse structural plasticity (GO:0051823)3.85112827
68regulation of glutamate receptor signaling pathway (GO:1900449)3.83896422
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82888914
70amino acid import (GO:0043090)3.81295032
71regulation of synapse maturation (GO:0090128)3.78862339
72NIK/NF-kappaB signaling (GO:0038061)3.78037078
73neurotransmitter-gated ion channel clustering (GO:0072578)3.75842637
74regulation of B cell differentiation (GO:0045577)3.75594075
75regulation of long-term neuronal synaptic plasticity (GO:0048169)3.72560106
76regulation of neurotransmitter levels (GO:0001505)3.72437458
77neuronal ion channel clustering (GO:0045161)3.71740833
78regulation of vesicle fusion (GO:0031338)3.71407708
79dendritic spine morphogenesis (GO:0060997)3.71157151
80neuron-neuron synaptic transmission (GO:0007270)3.69053877
81auditory behavior (GO:0031223)3.66592135
82antigen receptor-mediated signaling pathway (GO:0050851)3.66251435
83tolerance induction (GO:0002507)3.65203996
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.64398820
85negative regulation of phagocytosis (GO:0050765)3.62084999
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.56571999
87neuron recognition (GO:0008038)3.52681833
88positive regulation of lamellipodium assembly (GO:0010592)3.52603870
89regulation of dendritic spine morphogenesis (GO:0061001)3.52362007
90regulation of alpha-beta T cell proliferation (GO:0046640)3.49233044
91glutamate receptor signaling pathway (GO:0007215)3.49056783
92positive regulation of isotype switching (GO:0045830)3.48319680
93positive regulation of membrane potential (GO:0045838)3.48122957
94regulation of neurotransmitter secretion (GO:0046928)3.46805658
95neuromuscular process controlling balance (GO:0050885)3.46289107
96axonal fasciculation (GO:0007413)3.45498727
97potassium ion homeostasis (GO:0055075)3.44506499
98positive regulation of dendritic spine development (GO:0060999)3.44232237
99regulation of T cell receptor signaling pathway (GO:0050856)3.41442825
100B cell receptor signaling pathway (GO:0050853)3.40491811
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.38074228
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37162925
103regulation of synaptic plasticity (GO:0048167)3.36891867
104regulation of response to interferon-gamma (GO:0060330)3.36605621
105L-amino acid import (GO:0043092)3.35689251
106regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34631397
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.34083692
108regulation of type I interferon-mediated signaling pathway (GO:0060338)3.33573523
109dendritic spine organization (GO:0097061)3.32621539
110regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.32077929
111cerebellar Purkinje cell layer development (GO:0021680)3.30771710
112regulation of voltage-gated calcium channel activity (GO:1901385)3.26922654
113cerebellar Purkinje cell differentiation (GO:0021702)3.26893557
114positive regulation of B cell differentiation (GO:0045579)3.26653064
115cell communication by electrical coupling (GO:0010644)3.25808019
116mitochondrion transport along microtubule (GO:0047497)3.25590925
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.25590925
118leukocyte cell-cell adhesion (GO:0007159)3.24939091
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.23643616
120positive regulation of humoral immune response (GO:0002922)3.23118659
121regulation of interleukin-2 biosynthetic process (GO:0045076)3.22880665
122mast cell activation (GO:0045576)3.22840936
123positive regulation of interleukin-2 production (GO:0032743)3.22723908
124regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22646869
125regulation of natural killer cell mediated immunity (GO:0002715)3.22646869
126long-term memory (GO:0007616)3.22125908
127nucleobase catabolic process (GO:0046113)3.20561793
128positive regulation of tolerance induction (GO:0002645)3.20199372
129neuromuscular synaptic transmission (GO:0007274)3.19554690
130regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18497674
131regulation of neurotransmitter transport (GO:0051588)3.14809779
132defense response to fungus (GO:0050832)3.14048665
133myeloid dendritic cell activation (GO:0001773)3.13976105
134activated T cell proliferation (GO:0050798)3.13626362
135positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13200851
136regulation of postsynaptic membrane potential (GO:0060078)3.12428511
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.11153954
138actin nucleation (GO:0045010)3.11100101
139positive regulation of B cell mediated immunity (GO:0002714)3.09899360
140positive regulation of immunoglobulin mediated immune response (GO:0002891)3.09899360
141regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06754668
142gamma-aminobutyric acid signaling pathway (GO:0007214)3.06683021
143positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.05978271
144membrane depolarization during action potential (GO:0086010)3.05353697
145T cell homeostasis (GO:0043029)3.05235985
146G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03139433
147negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.02758809
148positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01867218
149response to auditory stimulus (GO:0010996)3.00326164
150synaptic vesicle transport (GO:0048489)2.99248853
151establishment of synaptic vesicle localization (GO:0097480)2.99248853
152adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.98325865
153myeloid dendritic cell differentiation (GO:0043011)2.97631374
154positive regulation of lamellipodium organization (GO:1902745)2.97054267
155negative regulation of dendrite morphogenesis (GO:0050774)2.96710176
156regulation of isotype switching (GO:0045191)2.96026528
157membrane depolarization (GO:0051899)2.95803831
158lymphocyte migration (GO:0072676)2.95271173
159protein retention in ER lumen (GO:0006621)2.94443181
160proline transport (GO:0015824)2.93881085
161positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.93765504
162positive regulation of natural killer cell mediated immunity (GO:0002717)2.93765504
163positive regulation of neurotransmitter transport (GO:0051590)2.93252398
164negative regulation of microtubule polymerization (GO:0031115)2.93223885
165natural killer cell differentiation (GO:0001779)2.92958294
166regulation of B cell mediated immunity (GO:0002712)2.92631439
167presynaptic membrane assembly (GO:0097105)2.92540596
168regulation of dendritic spine development (GO:0060998)2.92289396
169transmission of nerve impulse (GO:0019226)2.92198680
170regulation of immunoglobulin mediated immune response (GO:0002889)2.91884036
171interferon-gamma-mediated signaling pathway (GO:0060333)2.91871362
172natural killer cell activation (GO:0030101)2.90695273
173dendrite morphogenesis (GO:0048813)2.90310862
174synapse assembly (GO:0007416)2.89643194
175response to type I interferon (GO:0034340)2.89300758
176neuromuscular process (GO:0050905)2.89156228
177regulation of tolerance induction (GO:0002643)2.88910107
178cell differentiation in hindbrain (GO:0021533)2.88684569
179cellular sodium ion homeostasis (GO:0006883)2.88516979
180presynaptic membrane organization (GO:0097090)2.88045240
181immune response-activating cell surface receptor signaling pathway (GO:0002429)2.87150743
182negative regulation of T cell receptor signaling pathway (GO:0050860)2.86755798
183positive regulation of immunoglobulin production (GO:0002639)2.85717933
184cellular response to zinc ion (GO:0071294)2.85562439
185cellular extravasation (GO:0045123)2.85188850
186type I interferon signaling pathway (GO:0060337)2.84289956
187cellular response to type I interferon (GO:0071357)2.84289956
188response to fungus (GO:0009620)2.82160585
189positive regulation of DNA recombination (GO:0045911)2.80741773
190negative regulation of lymphocyte mediated immunity (GO:0002707)2.79866646
191killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.79491433
192disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.79491433
193mast cell activation involved in immune response (GO:0002279)2.75490618
194mast cell degranulation (GO:0043303)2.75490618
195regulation of leukocyte mediated cytotoxicity (GO:0001910)2.75416163
196lymphocyte homeostasis (GO:0002260)2.73052678
197regulation of regulatory T cell differentiation (GO:0045589)2.72954403
198regulation of hypersensitivity (GO:0002883)2.72036707
199negative regulation of interleukin-12 production (GO:0032695)2.67860669
200mature B cell differentiation (GO:0002335)2.67660862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52920936
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse5.05166131
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.69575825
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.52244492
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.12249225
6MYC_22102868_ChIP-Seq_BL_Human3.72525487
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.24980236
8REST_21632747_ChIP-Seq_MESCs_Mouse3.24323574
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.23692249
10RARB_27405468_Chip-Seq_BRAIN_Mouse3.21857977
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19044701
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.14622655
13VDR_21846776_ChIP-Seq_THP-1_Human3.02460078
14REST_18959480_ChIP-ChIP_MESCs_Mouse3.00351788
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99937190
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87916150
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87492952
18MAF_26560356_Chip-Seq_TH1_Human2.79366532
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.79267070
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.78612273
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76493575
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.74173883
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.70153892
24MYB_26560356_Chip-Seq_TH2_Human2.69455851
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.68847097
26RUNX_20019798_ChIP-Seq_JUKART_Human2.66643719
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63887827
28* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62708264
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62708264
30* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61904722
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.56037605
32* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55461397
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53813123
34UTX_26944678_Chip-Seq_JUKART_Human2.53757958
35DROSHA_22980978_ChIP-Seq_HELA_Human2.52994561
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45839609
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45442853
38MYB_26560356_Chip-Seq_TH1_Human2.44949696
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44507186
40EZH2_27294783_Chip-Seq_ESCs_Mouse2.39748021
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38709396
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37709049
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36317320
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35237939
45SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34604256
46EED_16625203_ChIP-ChIP_MESCs_Mouse2.30498123
47* RNF2_27304074_Chip-Seq_ESCs_Mouse2.26949252
48* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25853229
49* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23131305
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21359485
51VDR_24763502_ChIP-Seq_THP-1_Human2.17843295
52* TCF7_22412390_ChIP-Seq_EML_Mouse2.17815352
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17581980
54IRF8_27001747_Chip-Seq_BMDM_Mouse2.15627544
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14122236
56ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09645132
57* RUNX1_22412390_ChIP-Seq_EML_Mouse2.08044490
58E2F7_22180533_ChIP-Seq_HELA_Human2.07969561
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07933265
60* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07416556
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.03077071
62* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02806194
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02471895
64SCL_19346495_ChIP-Seq_HPC-7_Human1.94159510
65SPI1_23547873_ChIP-Seq_NB4_Human1.92716735
66MAF_26560356_Chip-Seq_TH2_Human1.92312564
67GBX2_23144817_ChIP-Seq_PC3_Human1.92068105
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.91748184
69* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.90792255
70EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88726962
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86293021
72* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84667461
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.84246686
74KDM2B_26808549_Chip-Seq_DND41_Human1.82193334
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80645049
76* KDM2B_26808549_Chip-Seq_K562_Human1.78373080
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72334793
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71936672
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70020343
80GATA3_27048872_Chip-Seq_THYMUS_Human1.65371577
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64545403
82* RXR_22158963_ChIP-Seq_LIVER_Mouse1.63841419
83* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63811513
84SPI1_23127762_ChIP-Seq_K562_Human1.63403226
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60950722
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60897536
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.59154639
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58801770
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55209784
90LXR_22292898_ChIP-Seq_THP-1_Human1.54822355
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.54245624
92RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51508504
93OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.51221205
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50680567
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50372390
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.49079416
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.48673595
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46642436
99* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43344897
100CBX2_27304074_Chip-Seq_ESCs_Mouse1.35613326
101* RING1B_27294783_Chip-Seq_ESCs_Mouse1.35380910
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34859429
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34747973
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32219907
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.31913918
106AR_21572438_ChIP-Seq_LNCaP_Human1.28679173
107CTCF_27219007_Chip-Seq_Bcells_Human1.28378357
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27574136
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27258749
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27099955
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25183149
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25142272
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25074287
114* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24842423
115CIITA_25753668_ChIP-Seq_RAJI_Human1.22977466
116GATA1_22025678_ChIP-Seq_K562_Human1.20030252
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.19611049
118* RNF2_27304074_Chip-Seq_NSC_Mouse1.18907648
119GATA1_19941827_ChIP-Seq_MEL_Mouse1.18857410
120* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17963458
121* PU_27001747_Chip-Seq_BMDM_Mouse1.17432229
122TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17025964
123CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16650580
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15889472
125SMC4_20622854_ChIP-Seq_HELA_Human1.15860280
126KDM2B_26808549_Chip-Seq_JURKAT_Human1.13662315
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.13466024
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12877355
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11619791
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10841568
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10829876
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10457550
133THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08286474
134* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08136232
135AR_19668381_ChIP-Seq_PC3_Human1.07704963
136PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07615552
137ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06505584
138TP53_20018659_ChIP-ChIP_R1E_Mouse1.06482141
139* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05259690
140* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05130144
141LXR_22158963_ChIP-Seq_LIVER_Mouse1.04775597
142CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04487911
143GATA3_26560356_Chip-Seq_TH2_Human1.04062656
144CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03443005
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02665634
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02512098
147BCL6_27268052_Chip-Seq_Bcells_Human1.02445157
148CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01917347
149RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97433144
150NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.97073322
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96353070
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96328324
153CREB1_26743006_Chip-Seq_LNCaP_Human0.95417589
154OCT4_19829295_ChIP-Seq_ESCs_Human0.95187330
155MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94535608
156RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94353844
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93760226
158UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93398825
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93003886
160CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92833955
161EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92157844
162SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92005074
163NCOR1_26117541_ChIP-Seq_K562_Human0.91950507
164ELF1_20517297_ChIP-Seq_JURKAT_Human0.91375511
165RACK7_27058665_Chip-Seq_MCF-7_Human0.91360774
166* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90705194
167DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90564805
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90200149
169CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90188839
170* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89480572
171SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88320825
172ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87778331
173NR3C1_23031785_ChIP-Seq_PC12_Mouse0.87461031
174ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87179381
175CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86803346
176YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86475420
177GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85589700
178BCOR_27268052_Chip-Seq_Bcells_Human0.85060104
179TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84856513
180SOX9_26525672_Chip-Seq_HEART_Mouse0.84639509
181P68_20966046_ChIP-Seq_HELA_Human0.84429873
182RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83335518
183SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83330937
184BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83026432
185CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82903762
186STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.82024906
187GATA2_19941826_ChIP-Seq_K562_Human0.81946691
188* TP53_23651856_ChIP-Seq_MEFs_Mouse0.80182527
189CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79776896
190ESR2_21235772_ChIP-Seq_MCF-7_Human0.78235261
191POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.77389740
192FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75885833
193* SOX2_21211035_ChIP-Seq_LN229_Gbm0.74913090
194CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74815246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25817007
2MP0003880_abnormal_central_pattern4.37893897
3MP0004270_analgesia4.26858394
4MP0005423_abnormal_somatic_nervous3.94163825
5MP0003635_abnormal_synaptic_transmissio3.79553439
6MP0003763_abnormal_thymus_physiology3.73023695
7MP0001835_abnormal_antigen_presentation3.59141087
8MP0000685_abnormal_immune_system3.30761228
9MP0005671_abnormal_response_to3.27709316
10* MP0002064_seizures3.14094235
11MP0002063_abnormal_learning/memory/cond3.08404888
12MP0003303_peritoneal_inflammation3.03416824
13MP0003436_decreased_susceptibility_to2.95749338
14MP0001800_abnormal_humoral_immune2.93353608
15MP0009745_abnormal_behavioral_response2.91771001
16MP0009046_muscle_twitch2.91045914
17MP0005387_immune_system_phenotype2.88216644
18MP0001790_abnormal_immune_system2.88216644
19MP0002734_abnormal_mechanical_nocicepti2.74466006
20MP0009785_altered_susceptibility_to2.73043145
21MP0002272_abnormal_nervous_system2.72517681
22MP0002166_altered_tumor_susceptibility2.72247369
23MP0005000_abnormal_immune_tolerance2.62793314
24MP0001873_stomach_inflammation2.60478658
25MP0002420_abnormal_adaptive_immunity2.54582024
26MP0002723_abnormal_immune_serum2.53313454
27MP0005025_abnormal_response_to2.51103284
28MP0001819_abnormal_immune_cell2.51001547
29MP0002572_abnormal_emotion/affect_behav2.49911357
30MP0003300_gastrointestinal_ulcer2.48363740
31MP0001968_abnormal_touch/_nociception2.46071841
32MP0002452_abnormal_antigen_presenting2.44731176
33MP0002398_abnormal_bone_marrow2.36725848
34MP0001486_abnormal_startle_reflex2.27434885
35MP0008569_lethality_at_weaning2.19059895
36MP0005360_urolithiasis2.18687345
37MP0002396_abnormal_hematopoietic_system2.18362636
38MP0002405_respiratory_system_inflammati2.17482933
39MP0005464_abnormal_platelet_physiology2.17249776
40MP0002419_abnormal_innate_immunity2.17026022
41MP0002735_abnormal_chemical_nociception2.15788964
42* MP0000716_abnormal_immune_system2.14768595
43MP0010155_abnormal_intestine_physiology2.12801912
44MP0000778_abnormal_nervous_system2.12343087
45MP0003866_abnormal_defecation2.09960141
46MP0002006_tumorigenesis2.09279271
47MP0006082_CNS_inflammation2.00475969
48MP0004510_myositis1.99500763
49MP0009333_abnormal_splenocyte_physiolog1.99042908
50MP0004811_abnormal_neuron_physiology1.96786470
51MP0002722_abnormal_immune_system1.93041479
52MP0002148_abnormal_hypersensitivity_rea1.91531573
53MP0000689_abnormal_spleen_morphology1.91287793
54MP0003122_maternal_imprinting1.90922447
55MP0004947_skin_inflammation1.90033108
56MP0002736_abnormal_nociception_after1.89109459
57MP0003724_increased_susceptibility_to1.88946820
58MP0003879_abnormal_hair_cell1.83836643
59MP0009840_abnormal_foam_cell1.82936217
60MP0002733_abnormal_thermal_nociception1.81452482
61MP0001845_abnormal_inflammatory_respons1.79322005
62MP0001970_abnormal_pain_threshold1.77798452
63* MP0002429_abnormal_blood_cell1.77367116
64MP0000703_abnormal_thymus_morphology1.75052016
65MP0000955_abnormal_spinal_cord1.71098620
66MP0001501_abnormal_sleep_pattern1.70769484
67MP0006276_abnormal_autonomic_nervous1.69070119
68MP0002184_abnormal_innervation1.68730517
69MP0001188_hyperpigmentation1.68388669
70MP0001440_abnormal_grooming_behavior1.62645814
71MP0002557_abnormal_social/conspecific_i1.62096539
72MP0003191_abnormal_cellular_cholesterol1.62077024
73MP0001853_heart_inflammation1.62052791
74* MP0002067_abnormal_sensory_capabilities1.61549228
75* MP0002882_abnormal_neuron_morphology1.60521939
76* MP0002066_abnormal_motor_capabilities/c1.52754256
77MP0001529_abnormal_vocalization1.52237791
78MP0001502_abnormal_circadian_rhythm1.49493814
79MP0005310_abnormal_salivary_gland1.49234174
80MP0002138_abnormal_hepatobiliary_system1.47766164
81MP0005623_abnormal_meninges_morphology1.43872021
82MP0002139_abnormal_hepatobiliary_system1.43791961
83MP0008469_abnormal_protein_level1.42585022
84MP0004924_abnormal_behavior1.41290478
85MP0005386_behavior/neurological_phenoty1.41290478
86MP0003787_abnormal_imprinting1.41174436
87MP0005365_abnormal_bile_salt1.36866850
88MP0001984_abnormal_olfaction1.35741689
89MP0000604_amyloidosis1.32330444
90MP0001533_abnormal_skeleton_physiology1.29435579
91* MP0002152_abnormal_brain_morphology1.29162671
92MP0000465_gastrointestinal_hemorrhage1.27717959
93MP0002933_joint_inflammation1.27669257
94MP0009780_abnormal_chondrocyte_physiolo1.25291287
95MP0003172_abnormal_lysosome_physiology1.24824964
96MP0003123_paternal_imprinting1.23669591
97MP0005085_abnormal_gallbladder_physiolo1.22673566
98MP0000858_altered_metastatic_potential1.22397708
99MP0001177_atelectasis1.21784363
100MP0005646_abnormal_pituitary_gland1.21608252
101MP0004885_abnormal_endolymph1.20952793
102MP0000490_abnormal_crypts_of1.20632684
103MP0004808_abnormal_hematopoietic_stem1.19966590
104MP0001905_abnormal_dopamine_level1.17793175
105MP0001666_abnormal_nutrient_absorption1.17238199
106MP0000609_abnormal_liver_physiology1.16840077
107MP0004858_abnormal_nervous_system1.15957319
108MP0003183_abnormal_peptide_metabolism1.15431626
109MP0005397_hematopoietic_system_phenotyp1.12480247
110MP0001545_abnormal_hematopoietic_system1.12480247
111MP0008875_abnormal_xenobiotic_pharmacok1.11009069
112MP0001663_abnormal_digestive_system1.10674782
113MP0000920_abnormal_myelination1.09742603
114MP0004742_abnormal_vestibular_system1.08402065
115MP0010352_gastrointestinal_tract_polyps1.08382025
116MP0010329_abnormal_lipoprotein_level1.07873418
117MP0003634_abnormal_glial_cell1.07743840
118MP0010234_abnormal_vibrissa_follicle1.07598486
119MP0004142_abnormal_muscle_tone1.04702511
120MP0000751_myopathy1.04532140
121MP0005645_abnormal_hypothalamus_physiol1.04405339
122* MP0003633_abnormal_nervous_system1.02332135
123MP0008961_abnormal_basal_metabolism1.00962295
124MP0005058_abnormal_lysosome_morphology1.00504657
125MP0005083_abnormal_biliary_tract1.00425350
126* MP0003631_nervous_system_phenotype1.00403276
127MP0009764_decreased_sensitivity_to0.97799138
128MP0003252_abnormal_bile_duct0.96677160
129MP0003121_genomic_imprinting0.96429854
130MP0001851_eye_inflammation0.96159085
131MP0002229_neurodegeneration0.94668781
132MP0003861_abnormal_nervous_system0.94224030
133MP0002822_catalepsy0.94129844
134MP0005174_abnormal_tail_pigmentation0.91961980
135MP0003690_abnormal_glial_cell0.91046809
136MP0009763_increased_sensitivity_to0.90715932
137MP0002019_abnormal_tumor_incidence0.90052491
138MP0003448_altered_tumor_morphology0.88678095
139MP0002909_abnormal_adrenal_gland0.87468574
140MP0001299_abnormal_eye_distance/0.85603406
141MP0002752_abnormal_somatic_nervous0.84145583
142MP0003632_abnormal_nervous_system0.83883947
143MP0005166_decreased_susceptibility_to0.83840235
144MP0000462_abnormal_digestive_system0.83286772
145MP0002249_abnormal_larynx_morphology0.82985342
146MP0005394_taste/olfaction_phenotype0.82242971
147MP0005499_abnormal_olfactory_system0.82242971
148MP0003329_amyloid_beta_deposits0.81909894
149MP0002069_abnormal_eating/drinking_beha0.81155225
150MP0005584_abnormal_enzyme/coenzyme_acti0.80145733
151MP0009765_abnormal_xenobiotic_induced0.77881045
152MP0000579_abnormal_nail_morphology0.77422497
153MP0000631_abnormal_neuroendocrine_gland0.76576404
154* MP0001943_abnormal_respiration0.76481370
155MP0000534_abnormal_ureter_morphology0.75452992
156MP0003075_altered_response_to0.74798022
157MP0005075_abnormal_melanosome_morpholog0.73179654
158MP0002254_reproductive_system_inflammat0.73173476
159MP0003656_abnormal_erythrocyte_physiolo0.73090421
160MP0005076_abnormal_cell_differentiation0.71550238
161MP0010769_abnormal_survival0.70863478
162MP0002132_abnormal_respiratory_system0.70831722
163MP0001346_abnormal_lacrimal_gland0.70178433
164MP0001963_abnormal_hearing_physiology0.69833788
165MP0002081_perinatal_lethality0.69744832
166MP0005187_abnormal_penis_morphology0.69256210
167MP0002082_postnatal_lethality0.69173088
168MP0010770_preweaning_lethality0.69173088
169MP0000598_abnormal_liver_morphology0.67976276
170MP0010768_mortality/aging0.67757103
171MP0008873_increased_physiological_sensi0.67008300
172MP0005409_darkened_coat_color0.66684002
173MP0005023_abnormal_wound_healing0.66641721
174MP0009278_abnormal_bone_marrow0.66342847
175MP0001348_abnormal_lacrimal_gland0.65836454
176MP0003385_abnormal_body_wall0.65681946
177MP0008874_decreased_physiological_sensi0.65003626
178MP0004233_abnormal_muscle_weight0.63987117
179MP0005319_abnormal_enzyme/_coenzyme0.63383152
180MP0000477_abnormal_intestine_morphology0.62761057
181MP0002638_abnormal_pupillary_reflex0.62009440
182MP0002136_abnormal_kidney_physiology0.61658387
183MP0000747_muscle_weakness0.60793163
184MP0002998_abnormal_bone_remodeling0.60639432
185MP0001881_abnormal_mammary_gland0.59597833
186MP0005551_abnormal_eye_electrophysiolog0.59240740
187MP0009643_abnormal_urine_homeostasis0.59217666
188MP0010386_abnormal_urinary_bladder0.58730495
189MP0001986_abnormal_taste_sensitivity0.58399295
190MP0003956_abnormal_body_size0.57750267
191MP0003938_abnormal_ear_development0.55833449
192MP0003137_abnormal_impulse_conducting0.55053839
193MP0000026_abnormal_inner_ear0.50377311
194MP0000537_abnormal_urethra_morphology0.49499650
195MP0003942_abnormal_urinary_system0.47921360

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.73495863
2Focal motor seizures (HP:0011153)5.48126963
3Eczematoid dermatitis (HP:0000976)5.21180731
4Focal seizures (HP:0007359)4.85969754
5Chronic otitis media (HP:0000389)4.74601484
6Elevated erythrocyte sedimentation rate (HP:0003565)4.61718181
7Epileptic encephalopathy (HP:0200134)4.56095897
8Nasal polyposis (HP:0100582)4.47005743
9T lymphocytopenia (HP:0005403)4.44680406
10Recurrent fungal infections (HP:0002841)4.41077017
11Supranuclear gaze palsy (HP:0000605)4.34843088
12Atonic seizures (HP:0010819)4.32219651
13Abnormality of T cell number (HP:0011839)4.31508793
14Febrile seizures (HP:0002373)4.22438621
15Recurrent bronchitis (HP:0002837)4.17620342
16Ankle clonus (HP:0011448)4.03093163
17Stomatitis (HP:0010280)3.97219036
18Action tremor (HP:0002345)3.96653760
19Abnormality of T cells (HP:0002843)3.89922522
20Panhypogammaglobulinemia (HP:0003139)3.86036889
21Recurrent viral infections (HP:0004429)3.85265647
22IgM deficiency (HP:0002850)3.81097875
23Recurrent abscess formation (HP:0002722)3.81065363
24Recurrent cutaneous fungal infections (HP:0011370)3.80818438
25Chronic mucocutaneous candidiasis (HP:0002728)3.80818438
26Abnormality of the nasal mucosa (HP:0000433)3.74941287
27Severe combined immunodeficiency (HP:0004430)3.74514023
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.72214698
29Combined immunodeficiency (HP:0005387)3.65130106
30Thrombocytosis (HP:0001894)3.56459796
31Pustule (HP:0200039)3.54817515
32* Spastic gait (HP:0002064)3.46982572
33Recurrent bacterial skin infections (HP:0005406)3.42629917
34Generalized tonic-clonic seizures (HP:0002069)3.41178314
35Myositis (HP:0100614)3.41092141
36Limb dystonia (HP:0002451)3.41018219
37Abnormality of T cell physiology (HP:0011840)3.30190445
38Neurofibrillary tangles (HP:0002185)3.27622143
39Recurrent gram-negative bacterial infections (HP:0005420)3.23368512
40Cerebral hypomyelination (HP:0006808)3.20324501
41Recurrent skin infections (HP:0001581)3.19632026
42Inflammation of the large intestine (HP:0002037)3.17820500
43Gastrointestinal inflammation (HP:0004386)3.14163302
44Meningitis (HP:0001287)3.12420795
45Urinary bladder sphincter dysfunction (HP:0002839)3.06759183
46Abnormality of binocular vision (HP:0011514)3.04578137
47Diplopia (HP:0000651)3.04578137
48Epileptiform EEG discharges (HP:0011182)3.03677723
49Abnormality of the corticospinal tract (HP:0002492)3.02931667
50Increased IgE level (HP:0003212)3.02474575
51Autoimmune thrombocytopenia (HP:0001973)3.02124533
52Absence seizures (HP:0002121)3.00881852
53Mediastinal lymphadenopathy (HP:0100721)2.96473285
54Lymphopenia (HP:0001888)2.96242647
55Truncal ataxia (HP:0002078)2.93629719
56Abnormal eating behavior (HP:0100738)2.93476875
57Abnormality of cells of the lymphoid lineage (HP:0012140)2.92164711
58* Urinary urgency (HP:0000012)2.91994188
59Obstructive lung disease (HP:0006536)2.91124401
60Chronic obstructive pulmonary disease (HP:0006510)2.91124401
61Gastrointestinal infarctions (HP:0005244)2.90971641
62Mutism (HP:0002300)2.88691957
63Insomnia (HP:0100785)2.87705480
64EEG with generalized epileptiform discharges (HP:0011198)2.87326404
65Spontaneous hematomas (HP:0007420)2.87037094
66Cerebral inclusion bodies (HP:0100314)2.86970787
67Progressive cerebellar ataxia (HP:0002073)2.86942438
68Vasculitis (HP:0002633)2.84662304
69IgG deficiency (HP:0004315)2.83392048
70Agammaglobulinemia (HP:0004432)2.81488045
71Epistaxis (HP:0000421)2.77841383
72Akinesia (HP:0002304)2.75402426
73Hypsarrhythmia (HP:0002521)2.75227335
74Depression (HP:0000716)2.74350855
75Abnormality of B cell number (HP:0010975)2.74230368
76B lymphocytopenia (HP:0010976)2.74230368
77Torticollis (HP:0000473)2.73894297
78Gingival bleeding (HP:0000225)2.72347985
79Chest pain (HP:0100749)2.71993874
80Colitis (HP:0002583)2.69609164
81Drooling (HP:0002307)2.69266524
82Dialeptic seizures (HP:0011146)2.69169461
83Abnormality of eosinophils (HP:0001879)2.68669307
84Periodontitis (HP:0000704)2.68314764
85Eosinophilia (HP:0001880)2.67292315
86Failure to thrive in infancy (HP:0001531)2.66859496
87Joint swelling (HP:0001386)2.66140726
88Chronic diarrhea (HP:0002028)2.65681595
89Impaired vibration sensation in the lower limbs (HP:0002166)2.65228283
90Leukocytosis (HP:0001974)2.64534774
91Abnormality of the lower motor neuron (HP:0002366)2.63390655
92Tetraplegia (HP:0002445)2.63044609
93Papilloma (HP:0012740)2.60616259
94Verrucae (HP:0200043)2.60616259
95Amblyopia (HP:0000646)2.57625649
96Hypergammaglobulinemia (HP:0010702)2.56213784
97Annular pancreas (HP:0001734)2.55844130
98Visual hallucinations (HP:0002367)2.52600974
99Granulocytopenia (HP:0001913)2.51855643
100Gingivitis (HP:0000230)2.50798727
101Hemoptysis (HP:0002105)2.50385734
102Lower limb muscle weakness (HP:0007340)2.49718301
103Impaired platelet aggregation (HP:0003540)2.47691792
104Abnormal platelet function (HP:0011869)2.47691792
105Polyphagia (HP:0002591)2.47170377
106Thyroiditis (HP:0100646)2.46662760
107Neuronal loss in central nervous system (HP:0002529)2.45092884
108Abnormality of the fingertips (HP:0001211)2.45065260
109Postural instability (HP:0002172)2.44981673
110Poor eye contact (HP:0000817)2.44203581
111Pulmonary infiltrates (HP:0002113)2.44089464
112* Dysmetria (HP:0001310)2.43140675
113Recurrent sinusitis (HP:0011108)2.42757635
114Peripheral hypomyelination (HP:0007182)2.42733273
115Excessive salivation (HP:0003781)2.42697029
116Apathy (HP:0000741)2.41322360
117Intention tremor (HP:0002080)2.41223094
118Encephalitis (HP:0002383)2.40325658
119Obstructive sleep apnea (HP:0002870)2.40087275
120Interstitial pulmonary disease (HP:0006530)2.39114975
121Chronic sinusitis (HP:0011109)2.39088508
122Autoimmune hemolytic anemia (HP:0001890)2.37588686
123Delusions (HP:0000746)2.37577531
124Status epilepticus (HP:0002133)2.36694883
125Cellulitis (HP:0100658)2.35849838
126Sleep apnea (HP:0010535)2.34624750
127Lower limb amyotrophy (HP:0007210)2.34153945
128Hypoplasia of the thymus (HP:0000778)2.33207887
129Absent speech (HP:0001344)2.32272430
130Increased IgM level (HP:0003496)2.31939234
131Arterial thrombosis (HP:0004420)2.31135707
132Abnormal platelet volume (HP:0011876)2.30629487
133Prolonged bleeding time (HP:0003010)2.29957788
134Bronchitis (HP:0012387)2.29245006
135Focal dystonia (HP:0004373)2.28136926
136Pulmonary embolism (HP:0002204)2.28135036
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.26633440
138Clonus (HP:0002169)2.26562617
139Petechiae (HP:0000967)2.24362709
140Abnormality of macrophages (HP:0004311)2.22547928
141Anxiety (HP:0000739)2.21526207
142CNS hypomyelination (HP:0003429)2.20600741
143Cortical dysplasia (HP:0002539)2.20437275
144Hand muscle atrophy (HP:0009130)2.19402255
145Termporal pattern (HP:0011008)2.16946741
146Insidious onset (HP:0003587)2.16946741
147Diminished motivation (HP:0000745)2.16646370
148Morphological abnormality of the pyramidal tract (HP:0002062)2.14857528
149Hyperacusis (HP:0010780)2.13629256
150Upper limb amyotrophy (HP:0009129)2.10990677
151Distal upper limb amyotrophy (HP:0007149)2.10990677
152Deep venous thrombosis (HP:0002625)2.09884293
153Hypoplasia of the brainstem (HP:0002365)2.09805920
154Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09805920
155Orchitis (HP:0100796)2.08585508
156Fatigue (HP:0012378)2.08494722
157Cheilitis (HP:0100825)2.06853202
158Bradykinesia (HP:0002067)2.06811038
159Hemiparesis (HP:0001269)2.06631685
160Broad-based gait (HP:0002136)2.05724120
161Craniofacial dystonia (HP:0012179)2.05652199
162Abnormal social behavior (HP:0012433)2.04574853
163Impaired social interactions (HP:0000735)2.04574853
164Hypoplasia of the corpus callosum (HP:0002079)2.04303512
165Pointed chin (HP:0000307)2.03623993
166Hepatitis (HP:0012115)2.03372841
167Hammertoe (HP:0001765)2.03346980
168Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01799936
169Degeneration of the lateral corticospinal tracts (HP:0002314)2.01799936
170Urticaria (HP:0001025)2.01528448
171Scanning speech (HP:0002168)2.01434394
172Skin ulcer (HP:0200042)2.01305832
173IgA deficiency (HP:0002720)2.01290399
174Impaired smooth pursuit (HP:0007772)2.01219607
175Spastic tetraparesis (HP:0001285)2.01138821
176Joint hemorrhage (HP:0005261)1.99788975
177Retinal dysplasia (HP:0007973)1.98466279
178Abnormality of the prostate (HP:0008775)1.97482079
179Increased density of long bones (HP:0006392)1.97336174
180Spastic tetraplegia (HP:0002510)1.96656672
181Amyotrophic lateral sclerosis (HP:0007354)1.96161682
182Hypoventilation (HP:0002791)1.95610673
183Emphysema (HP:0002097)1.94067557
184Incomplete penetrance (HP:0003829)1.90943903
185Gastrointestinal stroma tumor (HP:0100723)1.90513529
186Myocardial infarction (HP:0001658)1.89905109
187Lymphoma (HP:0002665)1.87731237
188Hypobetalipoproteinemia (HP:0003563)1.87722265
189Increased mean platelet volume (HP:0011877)1.87449602
190Abnormality of the common coagulation pathway (HP:0010990)1.85957726
191Skin rash (HP:0000988)1.85531065
192Thoracic kyphosis (HP:0002942)1.85385437
193Paraplegia (HP:0010550)1.83392190
194Hyperventilation (HP:0002883)1.82942275
195Genetic anticipation (HP:0003743)1.82601356
196Rapidly progressive (HP:0003678)1.82166068
197Split foot (HP:0001839)1.81481790
198Poor suck (HP:0002033)1.78279860
199Papilledema (HP:0001085)1.78236546
200Spastic paraplegia (HP:0001258)1.76115043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.72519209
2MARK15.04201023
3EPHA44.01034903
4PAK63.50999634
5TXK3.36056470
6ZAP703.05548112
7NTRK33.00064025
8GRK62.71077159
9TYK22.62240635
10JAK32.59975580
11NTRK22.56325085
12PRKD32.47195958
13NTRK12.39098591
14ITK2.36627516
15CASK2.36052570
16FGFR42.32289159
17BLK2.26224009
18MINK12.25705082
19ERN12.23273354
20UHMK12.21581913
21EEF2K2.21011843
22MAP2K72.16082196
23IKBKE2.13747657
24STK102.09949667
25TRIB32.01688630
26JAK11.99948977
27MAP3K141.97759423
28PKN21.95671987
29TBK11.92160080
30MAP3K41.89447434
31MAP3K131.88814669
32MAPK131.85716962
33BTK1.83865811
34TESK21.82898499
35MAP3K101.69805530
36IRAK41.69079075
37SYK1.68573641
38TEC1.62716776
39FES1.61348367
40LATS21.59103657
41ARAF1.52819765
42LCK1.52051386
43PHKG21.48701797
44PHKG11.48701797
45LRRK21.48695988
46TAOK11.48014532
47CSK1.45666821
48SIK21.45452302
49LIMK11.44952959
50KDR1.43615602
51KIT1.41506558
52CAMK2B1.40487386
53HCK1.40430144
54CDK51.39587992
55CDK181.36360056
56CDK151.36201296
57CDK141.29499866
58MAP2K31.27818996
59CDK11A1.26181778
60PLK21.24149403
61RIPK41.22287630
62BRSK11.17701129
63MAP3K121.16760799
64TAOK31.15054464
65FGFR31.12661561
66PRKCG1.12098779
67ICK1.10906888
68EPHB11.10479322
69IKBKB1.10478974
70TYRO31.09807497
71MAP3K111.07802108
72JAK21.06689887
73STK381.06604189
74CSF1R1.04892236
75BCR1.04150797
76MAP2K40.99014199
77KSR10.98860405
78CAMK2G0.98701844
79PRKCQ0.96333960
80NLK0.94349552
81CAMKK20.93783360
82CSNK1G20.93679601
83RPS6KA40.93159053
84PRKCH0.92606756
85CAMK10.89507906
86DYRK1A0.88917910
87MAP3K70.87489461
88TESK10.87233715
89DYRK20.85912383
90LYN0.85895633
91PTK60.85184001
92CSNK1A1L0.84738549
93GRK50.84684755
94SIK10.84629806
95CAMK2A0.83815987
96PAK30.83396892
97TNK20.82871668
98LMTK20.81676940
99SGK2230.81352682
100SGK4940.81352682
101CSNK1G30.79556088
102CHUK0.77735841
103MST40.74752553
104PIM10.74429483
105NME20.73500677
106SIK30.71663697
107PIM20.71523245
108CAMK40.71412222
109DAPK10.70533100
110CLK10.70482092
111ALK0.70068864
112RAF10.70020037
113SCYL20.69609247
114BRAF0.68439293
115PKN10.67736400
116PDK10.66934293
117FLT30.64202411
118MAP2K60.63231698
119PRKCI0.62329509
120MAPK100.62321609
121PTK20.59228197
122PINK10.59119392
123CAMK2D0.58861801
124MAP3K60.57203897
125TRIM280.56601444
126PDGFRA0.55183492
127PRPF4B0.54650726
128MAP3K80.53018458
129DAPK30.52906274
130MAPK120.52015274
131PRKCZ0.51107261
132MARK30.51070229
133MAPK40.50028768
134RPS6KA20.49225615
135MAP3K10.48583994
136IRAK30.48295377
137MAPK110.46982519
138CDK40.46478395
139RPS6KA30.45732191
140FYN0.41584461
141NEK60.41519921
142CCNB10.40144290
143CDK120.39363320
144MAPKAPK50.39138943
145SGK30.38493176
146KSR20.38348782
147PNCK0.37775184
148CSNK1G10.37747085
149CSNK1D0.36747935
150TGFBR20.36361488
151CAMKK10.36213383
152CSNK1E0.34136721
153SGK10.33329915
154ROCK20.33284800
155RET0.32261497
156DAPK20.31597993
157RPS6KB10.31388312
158CDK190.31233972
159RPS6KA60.31016906
160TAOK20.30808721
161MAPK80.29817401
162GSK3B0.29636112
163AURKA0.29379325
164HIPK20.27133051
165ABL10.26377333
166MARK20.26179037
167EGFR0.26091366
168PDPK10.24735407
169MAP3K90.24709596
170MAP3K50.23325463
171PRKCD0.23293158
172STK110.23115453
173TTN0.22927728
174EIF2AK30.21605208
175PDGFRB0.21443511
176RPS6KL10.19829351
177RPS6KC10.19829351
178CDK60.19803919
179RIPK10.19751856

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.97201166
2Nicotine addiction_Homo sapiens_hsa050334.25550731
3Synaptic vesicle cycle_Homo sapiens_hsa047214.12187566
4T cell receptor signaling pathway_Homo sapiens_hsa046603.14882514
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.05768641
6GABAergic synapse_Homo sapiens_hsa047272.83226030
7Leishmaniasis_Homo sapiens_hsa051402.66003127
8B cell receptor signaling pathway_Homo sapiens_hsa046622.59093354
9Antigen processing and presentation_Homo sapiens_hsa046122.58585365
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51884421
11Morphine addiction_Homo sapiens_hsa050322.47569948
12Long-term potentiation_Homo sapiens_hsa047202.40819090
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.40155114
14Glutamatergic synapse_Homo sapiens_hsa047242.38005226
15Circadian entrainment_Homo sapiens_hsa047132.36499770
16NF-kappa B signaling pathway_Homo sapiens_hsa040642.36232329
17Measles_Homo sapiens_hsa051622.35287760
18Amphetamine addiction_Homo sapiens_hsa050312.34089462
19Intestinal immune network for IgA production_Homo sapiens_hsa046722.33549302
20Osteoclast differentiation_Homo sapiens_hsa043802.30258118
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.18229186
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.15479873
23Dopaminergic synapse_Homo sapiens_hsa047282.11562133
24Cocaine addiction_Homo sapiens_hsa050302.01143947
25Insulin secretion_Homo sapiens_hsa049111.86827823
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83393758
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76214298
28Staphylococcus aureus infection_Homo sapiens_hsa051501.74802319
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74124513
30Graft-versus-host disease_Homo sapiens_hsa053321.73641955
31Cholinergic synapse_Homo sapiens_hsa047251.68263766
32Gastric acid secretion_Homo sapiens_hsa049711.68029084
33Hematopoietic cell lineage_Homo sapiens_hsa046401.67554544
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59980115
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59919112
36Vibrio cholerae infection_Homo sapiens_hsa051101.58159310
37Acute myeloid leukemia_Homo sapiens_hsa052211.58154489
38Allograft rejection_Homo sapiens_hsa053301.56032368
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53854504
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51068071
41Toxoplasmosis_Homo sapiens_hsa051451.48495680
42Glioma_Homo sapiens_hsa052141.45237543
43Shigellosis_Homo sapiens_hsa051311.42986447
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.42843900
45Chemokine signaling pathway_Homo sapiens_hsa040621.42482876
46Gap junction_Homo sapiens_hsa045401.41469024
47Viral myocarditis_Homo sapiens_hsa054161.39379183
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39070566
49Vitamin B6 metabolism_Homo sapiens_hsa007501.34331137
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33839404
51Oxytocin signaling pathway_Homo sapiens_hsa049211.32448469
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.31938186
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.31712145
54Long-term depression_Homo sapiens_hsa047301.30197239
55Axon guidance_Homo sapiens_hsa043601.29215063
56Herpes simplex infection_Homo sapiens_hsa051681.28630022
57Salivary secretion_Homo sapiens_hsa049701.27654380
58Taste transduction_Homo sapiens_hsa047421.25825795
59Influenza A_Homo sapiens_hsa051641.22400568
60Tuberculosis_Homo sapiens_hsa051521.21289296
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20053761
62Hepatitis B_Homo sapiens_hsa051611.19621695
63VEGF signaling pathway_Homo sapiens_hsa043701.19612808
64Nitrogen metabolism_Homo sapiens_hsa009101.17762913
65cAMP signaling pathway_Homo sapiens_hsa040241.17559132
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15868604
67Caffeine metabolism_Homo sapiens_hsa002321.14911396
68Apoptosis_Homo sapiens_hsa042101.14211100
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13578992
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12156171
71Collecting duct acid secretion_Homo sapiens_hsa049661.11562917
72ErbB signaling pathway_Homo sapiens_hsa040121.11391599
73TNF signaling pathway_Homo sapiens_hsa046681.09671971
74Pertussis_Homo sapiens_hsa051331.08977697
75Oocyte meiosis_Homo sapiens_hsa041141.08664952
76Calcium signaling pathway_Homo sapiens_hsa040201.08384587
77Legionellosis_Homo sapiens_hsa051341.07845324
78Estrogen signaling pathway_Homo sapiens_hsa049151.07770422
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06653091
80Pancreatic cancer_Homo sapiens_hsa052121.06192521
81GnRH signaling pathway_Homo sapiens_hsa049121.06123083
82Pentose phosphate pathway_Homo sapiens_hsa000301.05187410
83Cardiac muscle contraction_Homo sapiens_hsa042601.03688182
84Chronic myeloid leukemia_Homo sapiens_hsa052201.00778478
85Melanogenesis_Homo sapiens_hsa049160.93847587
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92863863
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.91721150
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91479709
89Serotonergic synapse_Homo sapiens_hsa047260.91200897
90Platelet activation_Homo sapiens_hsa046110.89345787
91Hepatitis C_Homo sapiens_hsa051600.89202027
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.88668397
93Arginine biosynthesis_Homo sapiens_hsa002200.87743638
94Renin secretion_Homo sapiens_hsa049240.87467344
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84997934
96Prion diseases_Homo sapiens_hsa050200.83916494
97Type II diabetes mellitus_Homo sapiens_hsa049300.83414826
98Salmonella infection_Homo sapiens_hsa051320.83287056
99Olfactory transduction_Homo sapiens_hsa047400.83229403
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82611430
101Prolactin signaling pathway_Homo sapiens_hsa049170.82260884
102Non-small cell lung cancer_Homo sapiens_hsa052230.81680257
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81193933
104Sulfur relay system_Homo sapiens_hsa041220.80396817
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78943852
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77982614
107Complement and coagulation cascades_Homo sapiens_hsa046100.76542496
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76531363
109ABC transporters_Homo sapiens_hsa020100.75463327
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73372911
111Autoimmune thyroid disease_Homo sapiens_hsa053200.73161581
112Dilated cardiomyopathy_Homo sapiens_hsa054140.71519004
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.70590418
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68911889
115Asthma_Homo sapiens_hsa053100.65119144
116Thyroid hormone synthesis_Homo sapiens_hsa049180.64840855
117AMPK signaling pathway_Homo sapiens_hsa041520.64420791
118Other glycan degradation_Homo sapiens_hsa005110.62530776
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62265222
120HTLV-I infection_Homo sapiens_hsa051660.62210038
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60918522
122Malaria_Homo sapiens_hsa051440.60821927
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59318829
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58861835
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57791862
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.57464665
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57128997
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56351154
129Colorectal cancer_Homo sapiens_hsa052100.56237673
130Choline metabolism in cancer_Homo sapiens_hsa052310.53972599
131Phototransduction_Homo sapiens_hsa047440.53876519
132Insulin resistance_Homo sapiens_hsa049310.53344544
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52931228
134MAPK signaling pathway_Homo sapiens_hsa040100.52864771
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.51980370
136Inositol phosphate metabolism_Homo sapiens_hsa005620.51934324
137Rap1 signaling pathway_Homo sapiens_hsa040150.51445763
138Ras signaling pathway_Homo sapiens_hsa040140.50835535
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50677813
140Hippo signaling pathway_Homo sapiens_hsa043900.50421089
141Alcoholism_Homo sapiens_hsa050340.50411612
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.50220779
143Pancreatic secretion_Homo sapiens_hsa049720.49841916
144Epstein-Barr virus infection_Homo sapiens_hsa051690.49592473
145Circadian rhythm_Homo sapiens_hsa047100.47472156
146Glucagon signaling pathway_Homo sapiens_hsa049220.47349910
147Insulin signaling pathway_Homo sapiens_hsa049100.44546201
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43618510
149Type I diabetes mellitus_Homo sapiens_hsa049400.43232378
150Renin-angiotensin system_Homo sapiens_hsa046140.41566140
151Endometrial cancer_Homo sapiens_hsa052130.41064688
152Arginine and proline metabolism_Homo sapiens_hsa003300.41063460
153Bile secretion_Homo sapiens_hsa049760.40849993
154Fat digestion and absorption_Homo sapiens_hsa049750.40711656
155Viral carcinogenesis_Homo sapiens_hsa052030.39206713
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38913268
157Endocytosis_Homo sapiens_hsa041440.38488426
158Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38456999
159Wnt signaling pathway_Homo sapiens_hsa043100.38097835
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.37403620
161Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36978088
162Thyroid cancer_Homo sapiens_hsa052160.36638415
163Glycosaminoglycan degradation_Homo sapiens_hsa005310.35967155
164Steroid biosynthesis_Homo sapiens_hsa001000.35746658
165Tight junction_Homo sapiens_hsa045300.34872085
166Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34350565
167Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34154009
168Lysosome_Homo sapiens_hsa041420.33919647
169Lysine degradation_Homo sapiens_hsa003100.33665467
170Renal cell carcinoma_Homo sapiens_hsa052110.33185186
171* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33109215
172Alzheimers disease_Homo sapiens_hsa050100.32926813
173Vascular smooth muscle contraction_Homo sapiens_hsa042700.32473106
174Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31504007
175Tryptophan metabolism_Homo sapiens_hsa003800.31394853
176N-Glycan biosynthesis_Homo sapiens_hsa005100.30468472
177Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30233516
178Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28597667
179African trypanosomiasis_Homo sapiens_hsa051430.25667791
180Glycerolipid metabolism_Homo sapiens_hsa005610.25224327
181Starch and sucrose metabolism_Homo sapiens_hsa005000.25221374
182mTOR signaling pathway_Homo sapiens_hsa041500.24439978
183Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23294535
184Biosynthesis of amino acids_Homo sapiens_hsa012300.22730070

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