B4GALNT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)8.07784145
2desmosome organization (GO:0002934)7.81201349
3axonemal dynein complex assembly (GO:0070286)7.05079695
4pentose metabolic process (GO:0019321)6.64761325
5regulation of cardioblast differentiation (GO:0051890)6.18684609
6auditory receptor cell differentiation (GO:0042491)5.76329810
7motile cilium assembly (GO:0044458)5.46244165
8cilium or flagellum-dependent cell motility (GO:0001539)5.34398738
9epithelial cell-cell adhesion (GO:0090136)5.11784624
10regulation of hippo signaling (GO:0035330)5.01449831
11regulation of posttranscriptional gene silencing (GO:0060147)4.89209978
12regulation of gene silencing by miRNA (GO:0060964)4.89209978
13regulation of gene silencing by RNA (GO:0060966)4.89209978
14regulation of somitogenesis (GO:0014807)4.81917421
15ventricular cardiac muscle cell action potential (GO:0086005)4.56355695
16intestinal epithelial cell development (GO:0060576)4.50564858
17negative regulation of myotube differentiation (GO:0010832)4.50445265
18protein polyglutamylation (GO:0018095)4.49754503
19gap junction assembly (GO:0016264)4.32407313
20cilium movement (GO:0003341)4.23675353
21cardiac myofibril assembly (GO:0055003)4.16965759
22negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.12712258
23notochord development (GO:0030903)4.10453232
24multicellular organismal water homeostasis (GO:0050891)4.01237277
25sarcomere organization (GO:0045214)4.00191108
26sperm capacitation (GO:0048240)3.94977596
27left/right pattern formation (GO:0060972)3.94366520
28Notch signaling involved in heart development (GO:0061314)3.93941883
29lung epithelium development (GO:0060428)3.92570620
30establishment of skin barrier (GO:0061436)3.88664731
31establishment of apical/basal cell polarity (GO:0035089)3.87804035
32hemidesmosome assembly (GO:0031581)3.86032320
33atrioventricular valve morphogenesis (GO:0003181)3.85906197
34anterior/posterior axis specification, embryo (GO:0008595)3.84252278
35cell communication involved in cardiac conduction (GO:0086065)3.82111515
36hair cell differentiation (GO:0035315)3.78911415
37trophectodermal cell differentiation (GO:0001829)3.78746399
38vitamin transmembrane transport (GO:0035461)3.76389927
39vitamin catabolic process (GO:0009111)3.67999653
40fat-soluble vitamin catabolic process (GO:0042363)3.67999653
41outflow tract septum morphogenesis (GO:0003148)3.64802025
42paraxial mesoderm development (GO:0048339)3.62335141
43cardiac muscle contraction (GO:0060048)3.61410608
44inner ear receptor cell differentiation (GO:0060113)3.56479722
45glomerular epithelial cell development (GO:0072310)3.56014694
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.52269243
47pre-miRNA processing (GO:0031054)3.49389975
48regulation of the force of heart contraction (GO:0002026)3.40232253
49myofibril assembly (GO:0030239)3.39199287
50cardiac muscle hypertrophy (GO:0003300)3.39005311
51ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.38615380
52cell junction maintenance (GO:0034331)3.35603334
53positive regulation of SMAD protein import into nucleus (GO:0060391)3.34990418
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32359814
55establishment of monopolar cell polarity (GO:0061162)3.30456837
56establishment or maintenance of monopolar cell polarity (GO:0061339)3.30456837
57epithelial cilium movement (GO:0003351)3.30187024
58establishment of tissue polarity (GO:0007164)3.23656520
59establishment of planar polarity (GO:0001736)3.23656520
60aorta morphogenesis (GO:0035909)3.23286559
61protein localization to kinetochore (GO:0034501)3.23243884
62regulation of translational fidelity (GO:0006450)3.21491535
63regulation of actin filament-based movement (GO:1903115)3.21046290
64ethanol metabolic process (GO:0006067)3.20231212
65water homeostasis (GO:0030104)3.19230611
66endocardial cushion morphogenesis (GO:0003203)3.18585048
67cardiac conduction (GO:0061337)3.17736684
68actomyosin structure organization (GO:0031032)3.17040252
69striated muscle hypertrophy (GO:0014897)3.15893703
70negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.15118039
71sulfur amino acid catabolic process (GO:0000098)3.13293203
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13185910
73glycoprotein catabolic process (GO:0006516)3.10593056
74nuclear pore organization (GO:0006999)3.09960058
75heterochromatin organization (GO:0070828)3.08924879
76proline biosynthetic process (GO:0006561)3.07972445
77cardiac muscle tissue morphogenesis (GO:0055008)3.07768322
78ectodermal placode formation (GO:0060788)3.07613240
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03239268
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.03239268
81cardiac right ventricle morphogenesis (GO:0003215)3.03237065
82nuclear pore complex assembly (GO:0051292)3.02534589
83cell communication by electrical coupling (GO:0010644)3.02397397
84negative regulation of androgen receptor signaling pathway (GO:0060766)3.02354285
85negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.01344384
86surfactant homeostasis (GO:0043129)3.00257876
87O-glycan processing (GO:0016266)2.97501341
88atrial septum morphogenesis (GO:0060413)2.95268673
89cell surface receptor signaling pathway involved in heart development (GO:0061311)2.95084378
90cardiac muscle hypertrophy in response to stress (GO:0014898)2.94448519
91muscle hypertrophy in response to stress (GO:0003299)2.94448519
92cardiac muscle adaptation (GO:0014887)2.94448519
93primary alcohol catabolic process (GO:0034310)2.93754743
94regulation of heart rate by cardiac conduction (GO:0086091)2.93306354
95Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.92835049
96planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92596660
97determination of adult lifespan (GO:0008340)2.90820826
98semaphorin-plexin signaling pathway (GO:0071526)2.90720155
99cardiac muscle cell development (GO:0055013)2.90219928
100negative regulation of striated muscle cell apoptotic process (GO:0010664)2.89360624
101DNA replication-dependent nucleosome assembly (GO:0006335)2.88037855
102DNA replication-dependent nucleosome organization (GO:0034723)2.88037855
103type B pancreatic cell proliferation (GO:0044342)2.87500043
104calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.87178771
105keratinization (GO:0031424)2.87133032
106apoptotic process involved in morphogenesis (GO:0060561)2.87101685
107polarized epithelial cell differentiation (GO:0030859)2.86792394
108ethanol oxidation (GO:0006069)2.86294659
109cardiac cell development (GO:0055006)2.85335695
110pathway-restricted SMAD protein phosphorylation (GO:0060389)2.84350436
111regulation of sister chromatid cohesion (GO:0007063)2.84252365
112convergent extension (GO:0060026)2.83392950
113lateral sprouting from an epithelium (GO:0060601)2.82759552
114cellular component maintenance (GO:0043954)2.81860101
115keratinocyte proliferation (GO:0043616)2.81776271
116striated muscle atrophy (GO:0014891)2.81389160
117regulation of establishment of planar polarity (GO:0090175)2.80617163
118embryonic process involved in female pregnancy (GO:0060136)2.80550041
119muscle tissue morphogenesis (GO:0060415)2.80391782
120regulation of SMAD protein import into nucleus (GO:0060390)2.79882370
121muscle hypertrophy (GO:0014896)2.79551199
122cell-cell junction maintenance (GO:0045217)2.78375904
123proline metabolic process (GO:0006560)2.78354368
124cardiac muscle cell action potential involved in contraction (GO:0086002)2.78022874
125interferon-gamma secretion (GO:0072643)2.77278373
126regulation of helicase activity (GO:0051095)2.76921282
127intracellular estrogen receptor signaling pathway (GO:0030520)2.75940227
128chemical homeostasis within a tissue (GO:0048875)2.75450387
129cardiac muscle cell action potential (GO:0086001)2.74213988
130histone H4-K12 acetylation (GO:0043983)2.73688590
131regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.73096864
132folic acid metabolic process (GO:0046655)2.71859723
133embryonic camera-type eye development (GO:0031076)2.71288595
134bone morphogenesis (GO:0060349)2.71225244
135regulation of cholesterol homeostasis (GO:2000188)2.70934712
136mitotic sister chromatid segregation (GO:0000070)2.69666407
137positive regulation of Notch signaling pathway (GO:0045747)2.69647887
138apical protein localization (GO:0045176)2.67779716
139ventricular trabecula myocardium morphogenesis (GO:0003222)2.67703627
140epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66597214
141receptor recycling (GO:0001881)2.66564268
142labyrinthine layer blood vessel development (GO:0060716)2.66317460
143negative regulation of striated muscle cell differentiation (GO:0051154)2.65661539
144mechanoreceptor differentiation (GO:0042490)2.65120530
145regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.64654797
146adult heart development (GO:0007512)2.64439975
147hypotonic response (GO:0006971)2.63540406
148embryonic heart tube development (GO:0035050)2.61766080
149retinoic acid receptor signaling pathway (GO:0048384)2.61686599
150striated muscle contraction (GO:0006941)2.60989546
151regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.60758005
152embryonic placenta development (GO:0001892)2.60497632
153regulation of heart rate (GO:0002027)2.59142762
154cardiac chamber formation (GO:0003207)2.58225419
155negative regulation of histone methylation (GO:0031061)2.57809730
156adherens junction assembly (GO:0034333)2.57414870
157drug catabolic process (GO:0042737)2.57280421
158intestinal absorption (GO:0050892)2.56990060
159male genitalia development (GO:0030539)2.56702170
160regulation of water loss via skin (GO:0033561)2.56346496
161striated muscle adaptation (GO:0014888)2.56227627
162muscle filament sliding (GO:0030049)2.56022298
163actin-myosin filament sliding (GO:0033275)2.56022298
164regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.55932063
165regulation of integrin activation (GO:0033623)2.55588438
166homocysteine metabolic process (GO:0050667)2.54592376
167regulation of histone H3-K9 methylation (GO:0051570)2.54352532
168COPI coating of Golgi vesicle (GO:0048205)2.54031854
169Golgi transport vesicle coating (GO:0048200)2.54031854
170regulation of gene silencing (GO:0060968)2.53515024
171cell-cell junction assembly (GO:0007043)2.52151531
172bone trabecula formation (GO:0060346)2.51964740
173modified amino acid transport (GO:0072337)2.51919963
174chromatin assembly (GO:0031497)2.50482396
175protein localization to chromosome, centromeric region (GO:0071459)2.50058022
176establishment or maintenance of apical/basal cell polarity (GO:0035088)2.48214882
177establishment or maintenance of bipolar cell polarity (GO:0061245)2.48214882
178sister chromatid segregation (GO:0000819)2.48197027
179positive regulation of Cdc42 GTPase activity (GO:0043089)2.47695800
180L-ascorbic acid metabolic process (GO:0019852)2.47596985
181cardiac ventricle morphogenesis (GO:0003208)2.47345274
182regulation of cardiac muscle cell apoptotic process (GO:0010665)2.46572399
183dorsal/ventral axis specification (GO:0009950)2.46568309
184urate metabolic process (GO:0046415)2.45219913
185cell migration involved in gastrulation (GO:0042074)2.44897451
186hippo signaling (GO:0035329)2.44681220
187neuronal stem cell maintenance (GO:0097150)2.44435601
188non-canonical Wnt signaling pathway (GO:0035567)2.44171117
189regulation of RNA export from nucleus (GO:0046831)2.41652567

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.20318196
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.54508478
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.54508478
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.54508478
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.22184523
6E2F7_22180533_ChIP-Seq_HELA_Human3.62204213
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.30928329
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.09559784
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.04693456
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.97051472
11NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.93222141
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.91587230
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.75148291
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.70909841
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.66283030
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.62642392
17* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.62538250
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58409693
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.51082776
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.38951163
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37605995
22NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.22291438
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.15477210
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.13572430
25NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.05308092
26POU5F1_16518401_ChIP-PET_MESCs_Mouse2.02408074
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.99243937
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97666585
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.91453963
30ZNF263_19887448_ChIP-Seq_K562_Human1.89798336
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.88296045
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83416719
33DROSHA_22980978_ChIP-Seq_HELA_Human1.80008891
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.78885285
35CTCF_27219007_Chip-Seq_Bcells_Human1.76871324
36* SMC4_20622854_ChIP-Seq_HELA_Human1.76676196
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.76519226
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76048072
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74258751
40NANOG_18692474_ChIP-Seq_MEFs_Mouse1.72457408
41* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.69042243
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.68150244
43TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.67505366
44TP63_22573176_ChIP-Seq_HFKS_Human1.65887462
45* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.65547776
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64944834
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.63899997
48* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.63754137
49AR_21909140_ChIP-Seq_LNCAP_Human1.62536553
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.56441850
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.56441850
52KLF5_25053715_ChIP-Seq_YYC3_Human1.56382568
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.55705081
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54309392
55SOX2_18692474_ChIP-Seq_MEFs_Mouse1.52768345
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52520708
57P68_20966046_ChIP-Seq_HELA_Human1.52308283
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51640430
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.50635454
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50325244
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.47641388
62ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43781159
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.40799226
64* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.40108397
65RACK7_27058665_Chip-Seq_MCF-7_Human1.39859723
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39305181
67TCF7_22412390_ChIP-Seq_EML_Mouse1.38783575
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38633197
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.38424619
70* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.37900973
71* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35009147
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.33925676
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33479741
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33261696
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.32164374
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32091847
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30900042
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.29628141
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28805092
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27024170
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25232849
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.24683532
83GATA6_25053715_ChIP-Seq_YYC3_Human1.24171967
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23128900
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.22798012
86* GATA4_25053715_ChIP-Seq_YYC3_Human1.21491016
87ATF3_27146783_Chip-Seq_COLON_Human1.21084438
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20701102
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.20534377
90SOX2_20726797_ChIP-Seq_SW620_Human1.19802704
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19363660
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19073826
93* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18571329
94KAP1_27257070_Chip-Seq_ESCs_Mouse1.18192095
95* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17744656
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17554939
97NANOG_16518401_ChIP-PET_MESCs_Mouse1.17157548
98PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16231575
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.15352729
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15155248
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15129864
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14898371
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14070101
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13894655
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13822159
106* TET1_21451524_ChIP-Seq_MESCs_Mouse1.13484559
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12783230
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12030996
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11577835
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07774103
111* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07177874
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07016279
113RXR_22158963_ChIP-Seq_LIVER_Mouse1.06439827
114MYC_19030024_ChIP-ChIP_MESCs_Mouse1.06304483
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05803573
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05166128
117* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05061023
118ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04364047
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04177134
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02515747
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02005481
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02002649
123MYC_22102868_ChIP-Seq_BL_Human1.00927239
124LXR_22292898_ChIP-Seq_THP-1_Human1.00710442
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00443392
126CLOCK_20551151_ChIP-Seq_293T_Human0.99689815
127P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99684499
128* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97959463
129JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.97637757
130BCOR_27268052_Chip-Seq_Bcells_Human0.97110098
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96858278
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96778325
133PHF8_20622854_ChIP-Seq_HELA_Human0.96541248
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.95750241
135TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94970078
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94652757
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94118323
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.93739103
139SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93658160
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93658160
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93575682
142TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93232520
143CREB1_26743006_Chip-Seq_LNCaP_Human0.92667614
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92065010
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91997715
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.91329963
147SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91315436
148MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90669827
149KDM2B_26808549_Chip-Seq_K562_Human0.90056562
150SA1_27219007_Chip-Seq_Bcells_Human0.89044969
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88806691
152KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88805472
153* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88039184
154EZH2_27294783_Chip-Seq_ESCs_Mouse0.87312273
155TP53_22127205_ChIP-Seq_IMR90_Human0.86197206
156KDM2B_26808549_Chip-Seq_DND41_Human0.85020789
157LXR_22158963_ChIP-Seq_LIVER_Mouse0.83382559
158* GATA3_24758297_ChIP-Seq_MCF-7_Human0.82674934
159ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82164472
160KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82128585
161MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81204910
162EGR1_19374776_ChIP-ChIP_THP-1_Human0.77843898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.41184447
2MP0003878_abnormal_ear_physiology5.41184447
3MP0001485_abnormal_pinna_reflex3.60635534
4MP0004264_abnormal_extraembryonic_tissu3.41158805
5MP0002653_abnormal_ependyma_morphology3.21188999
6MP0003879_abnormal_hair_cell3.11243650
7MP0004084_abnormal_cardiac_muscle2.93095385
8MP0003705_abnormal_hypodermis_morpholog2.77407255
9MP0010234_abnormal_vibrissa_follicle2.68888595
10MP0005360_urolithiasis2.62338554
11MP0000751_myopathy2.42759895
12MP0008004_abnormal_stomach_pH2.26679209
13MP0003941_abnormal_skin_development2.21451676
14MP0000678_abnormal_parathyroid_gland2.14655626
15MP0002837_dystrophic_cardiac_calcinosis2.06625964
16MP0010352_gastrointestinal_tract_polyps2.00736124
17MP0005330_cardiomyopathy1.97672875
18MP0001849_ear_inflammation1.95850213
19MP0003283_abnormal_digestive_organ1.94362806
20MP0004782_abnormal_surfactant_physiolog1.92646890
21MP0000026_abnormal_inner_ear1.91226231
22MP0003806_abnormal_nucleotide_metabolis1.90830303
23MP0001963_abnormal_hearing_physiology1.88889495
24MP0005409_darkened_coat_color1.81134239
25MP0004957_abnormal_blastocyst_morpholog1.80045377
26MP0004036_abnormal_muscle_relaxation1.79883216
27MP0010030_abnormal_orbit_morphology1.77617484
28MP0004215_abnormal_myocardial_fiber1.77096346
29MP0010630_abnormal_cardiac_muscle1.75807610
30MP0009780_abnormal_chondrocyte_physiolo1.70979083
31MP0002084_abnormal_developmental_patter1.61069198
32MP0005085_abnormal_gallbladder_physiolo1.60598870
33MP0003252_abnormal_bile_duct1.57543245
34MP0002249_abnormal_larynx_morphology1.54292093
35MP0002932_abnormal_joint_morphology1.52258703
36MP0002085_abnormal_embryonic_tissue1.52036281
37MP0002972_abnormal_cardiac_muscle1.51124574
38MP0003119_abnormal_digestive_system1.48507725
39MP0003890_abnormal_embryonic-extraembry1.48130527
40MP0002796_impaired_skin_barrier1.47501467
41MP0001216_abnormal_epidermal_layer1.45151687
42MP0003693_abnormal_embryo_hatching1.43933252
43MP0008057_abnormal_DNA_replication1.42931717
44MP0005380_embryogenesis_phenotype1.42295483
45MP0001672_abnormal_embryogenesis/_devel1.42295483
46MP0004885_abnormal_endolymph1.41872956
47MP0002086_abnormal_extraembryonic_tissu1.40513450
48MP0001293_anophthalmia1.39412066
49MP0000566_synostosis1.38702913
50MP0009053_abnormal_anal_canal1.38476788
51MP0000762_abnormal_tongue_morphology1.38439607
52MP0008775_abnormal_heart_ventricle1.37172841
53MP0002254_reproductive_system_inflammat1.36543014
54MP0001730_embryonic_growth_arrest1.34787344
55MP0003137_abnormal_impulse_conducting1.33273629
56MP0005508_abnormal_skeleton_morphology1.32612019
57MP0004043_abnormal_pH_regulation1.30400253
58MP0004133_heterotaxia1.29458684
59MP0000377_abnormal_hair_follicle1.26451660
60MP0001765_abnormal_ion_homeostasis1.26136353
61MP0004087_abnormal_muscle_fiber1.25098348
62MP0002111_abnormal_tail_morphology1.24464983
63MP0003111_abnormal_nucleus_morphology1.24052247
64MP0005670_abnormal_white_adipose1.23401883
65MP0005451_abnormal_body_composition1.21330944
66MP0004197_abnormal_fetal_growth/weight/1.21162047
67MP0000350_abnormal_cell_proliferation1.19704192
68MP0006138_congestive_heart_failure1.19530850
69MP0004858_abnormal_nervous_system1.19279517
70MP0005076_abnormal_cell_differentiation1.18848974
71MP0000537_abnormal_urethra_morphology1.17304301
72MP0003984_embryonic_growth_retardation1.17188850
73MP0002088_abnormal_embryonic_growth/wei1.16138933
74MP0000049_abnormal_middle_ear1.14501754
75MP0004019_abnormal_vitamin_homeostasis1.13234807
76MP0010678_abnormal_skin_adnexa1.12725610
77MP0003566_abnormal_cell_adhesion1.12346867
78MP0001697_abnormal_embryo_size1.11025452
79MP0000579_abnormal_nail_morphology1.08463296
80MP0000477_abnormal_intestine_morphology1.06510286
81MP0002139_abnormal_hepatobiliary_system1.05732756
82MP0002089_abnormal_postnatal_growth/wei1.05657750
83MP0005666_abnormal_adipose_tissue1.05190351
84MP0009384_cardiac_valve_regurgitation1.04785570
85MP0000467_abnormal_esophagus_morphology1.04177077
86MP0000534_abnormal_ureter_morphology1.03794771
87MP0005501_abnormal_skin_physiology1.03142219
88MP0009379_abnormal_foot_pigmentation1.02429916
89MP0010771_integument_phenotype1.02076689
90MP0003115_abnormal_respiratory_system1.01371236
91MP0000432_abnormal_head_morphology1.00798519
92MP0002127_abnormal_cardiovascular_syste1.00751632
93MP0001664_abnormal_digestion0.99960228
94MP0001286_abnormal_eye_development0.99000034
95MP0003453_abnormal_keratinocyte_physiol0.98286027
96MP0004185_abnormal_adipocyte_glucose0.98188136
97MP0001346_abnormal_lacrimal_gland0.98164213
98MP0003077_abnormal_cell_cycle0.96936039
99MP0004272_abnormal_basement_membrane0.93507884
100MP0004085_abnormal_heartbeat0.93473808
101MP0008789_abnormal_olfactory_epithelium0.92531980
102MP0002132_abnormal_respiratory_system0.91184114
103MP0008875_abnormal_xenobiotic_pharmacok0.91105096
104MP0002697_abnormal_eye_size0.90394003
105MP0001984_abnormal_olfaction0.90282547
106MP0000428_abnormal_craniofacial_morphol0.89621677
107MP0003937_abnormal_limbs/digits/tail_de0.88345996
108MP0002092_abnormal_eye_morphology0.87641465
109MP0005385_cardiovascular_system_phenoty0.87405588
110MP0001544_abnormal_cardiovascular_syste0.87405588
111MP0003755_abnormal_palate_morphology0.87330381
112MP0003567_abnormal_fetal_cardiomyocyte0.87228234
113MP0003942_abnormal_urinary_system0.86984945
114MP0002080_prenatal_lethality0.86275830
115MP0005165_increased_susceptibility_to0.85998584
116MP0000163_abnormal_cartilage_morphology0.85820519
117MP0002116_abnormal_craniofacial_bone0.84239381
118MP0002282_abnormal_trachea_morphology0.83647254
119MP0005623_abnormal_meninges_morphology0.83453606
120MP0010094_abnormal_chromosome_stability0.83097886
121MP0001666_abnormal_nutrient_absorption0.81667321
122MP0004510_myositis0.81613804
123MP0003938_abnormal_ear_development0.80548439
124MP0000003_abnormal_adipose_tissue0.80468579
125MP0005365_abnormal_bile_salt0.80201757
126MP0005394_taste/olfaction_phenotype0.79829508
127MP0005499_abnormal_olfactory_system0.79829508
128MP0005620_abnormal_muscle_contractility0.78964531
129MP0000516_abnormal_urinary_system0.78447290
130MP0005367_renal/urinary_system_phenotyp0.78447290
131MP0005275_abnormal_skin_tensile0.78360485
132MP0002115_abnormal_skeleton_extremities0.77997773
133MP0005375_adipose_tissue_phenotype0.77446633
134MP0000266_abnormal_heart_morphology0.77380272
135MP0000383_abnormal_hair_follicle0.76929441
136MP0000462_abnormal_digestive_system0.76834149
137MP0003935_abnormal_craniofacial_develop0.76036675
138MP0005503_abnormal_tendon_morphology0.75942354
139MP0002896_abnormal_bone_mineralization0.75670005
140MP0005248_abnormal_Harderian_gland0.75499354
141MP0002009_preneoplasia0.75491260
142MP0002925_abnormal_cardiovascular_devel0.73208077
143MP0000470_abnormal_stomach_morphology0.72653784
144MP0005023_abnormal_wound_healing0.72180890
145MP0002098_abnormal_vibrissa_morphology0.71153419
146MP0001915_intracranial_hemorrhage0.70479297
147MP0002060_abnormal_skin_morphology0.70263069
148MP0004947_skin_inflammation0.68851740
149MP0004484_altered_response_of0.68687450
150MP0000733_abnormal_muscle_development0.67426348
151MP0003828_pulmonary_edema0.65431168
152MP0002234_abnormal_pharynx_morphology0.63131421
153MP0001784_abnormal_fluid_regulation0.62347534
154MP0002233_abnormal_nose_morphology0.62282801

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.14634664
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.97901197
3Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.28607555
4Chronic bronchitis (HP:0004469)5.08185635
5Epiphyseal dysplasia (HP:0002656)5.06282980
6Hypoplastic ischia (HP:0003175)4.98270448
7Abnormal respiratory epithelium morphology (HP:0012253)4.94027266
8Abnormal respiratory motile cilium morphology (HP:0005938)4.94027266
9Abnormal respiratory motile cilium physiology (HP:0012261)4.86555913
10Hyperactive renin-angiotensin system (HP:0000841)4.83166708
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.78427381
12Absent/shortened dynein arms (HP:0200106)4.78427381
13Abnormal ciliary motility (HP:0012262)4.57690512
14Ventricular tachycardia (HP:0004756)4.54007671
15Rhinitis (HP:0012384)4.49343002
16Vertebral clefting (HP:0008428)4.45630321
17Abnormality of the ischium (HP:0003174)4.33528017
18Bilateral microphthalmos (HP:0007633)4.22203461
19Mixed hearing impairment (HP:0000410)4.00086908
20Anomalous pulmonary venous return (HP:0010772)3.91224522
21Nasal polyposis (HP:0100582)3.82185088
22Abnormality of the pubic bones (HP:0003172)3.80722170
23Sudden death (HP:0001699)3.75883515
24Abnormal vertebral ossification (HP:0100569)3.74679939
25Bronchiectasis (HP:0002110)3.50568011
26Abnormality of the nasal mucosa (HP:0000433)3.42280056
27Ependymoma (HP:0002888)3.37300106
28Syncope (HP:0001279)3.32710178
29Abnormality of the pulmonary veins (HP:0011718)3.29025130
30Fused cervical vertebrae (HP:0002949)3.10146072
31Pili torti (HP:0003777)3.05286594
32Humeroradial synostosis (HP:0003041)2.99844392
33Synostosis involving the elbow (HP:0003938)2.99844392
34Bundle branch block (HP:0011710)2.99475809
35Unilateral renal agenesis (HP:0000122)2.98459771
36Enlarged epiphyses (HP:0010580)2.95028220
37Decreased circulating renin level (HP:0003351)2.87204604
38Irregular epiphyses (HP:0010582)2.82754247
39Hyperkalemia (HP:0002153)2.81286695
40Oligodactyly (HP:0012165)2.78941154
41Mild short stature (HP:0003502)2.78528855
42Short humerus (HP:0005792)2.77918871
43Distal lower limb muscle weakness (HP:0009053)2.76920689
44Lip pit (HP:0100267)2.75878721
45Abnormality of chloride homeostasis (HP:0011422)2.72157584
46Abnormality of renin-angiotensin system (HP:0000847)2.71743393
47Atrial fibrillation (HP:0005110)2.71560916
48Abnormality of nail color (HP:0100643)2.69010090
49Rib fusion (HP:0000902)2.67460524
50Male infertility (HP:0003251)2.67363975
51Aplasia/hypoplasia of the humerus (HP:0006507)2.63177838
52Vitreoretinal degeneration (HP:0000655)2.63002201
53Synostosis of carpal bones (HP:0005048)2.61992035
54Abnormality of the salivary glands (HP:0010286)2.61694072
55Double outlet right ventricle (HP:0001719)2.61520045
56Congenital malformation of the right heart (HP:0011723)2.61520045
57Alopecia of scalp (HP:0002293)2.59044582
58Abnormality of the astrocytes (HP:0100707)2.58058007
59Astrocytoma (HP:0009592)2.58058007
60Metaphyseal cupping (HP:0003021)2.54708874
61Malnutrition (HP:0004395)2.52571872
62Abnormality of the aortic arch (HP:0012303)2.47412070
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.46545050
64Bell-shaped thorax (HP:0001591)2.46362926
65Mildly elevated creatine phosphokinase (HP:0008180)2.44804411
66Abnormality of the intervertebral disk (HP:0005108)2.44307397
67Abnormality of the lower motor neuron (HP:0002366)2.42499089
68Severe Myopia (HP:0011003)2.41595417
69Shawl scrotum (HP:0000049)2.37964824
70Ventricular fibrillation (HP:0001663)2.37626608
71Hyperaldosteronism (HP:0000859)2.37124072
72Ventricular arrhythmia (HP:0004308)2.37004856
73Delayed epiphyseal ossification (HP:0002663)2.34815600
74Vertebral fusion (HP:0002948)2.33871080
75Infertility (HP:0000789)2.33646037
76Primary atrial arrhythmia (HP:0001692)2.32560719
77Carpal synostosis (HP:0009702)2.27039735
78Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.26598059
79Absent epiphyses (HP:0010577)2.26598059
80Abnormality of the distal phalanx of the thumb (HP:0009617)2.25532261
81Woolly hair (HP:0002224)2.25269802
82Supraventricular tachycardia (HP:0004755)2.24384323
83Transposition of the great arteries (HP:0001669)2.21369450
84Abnormal connection of the cardiac segments (HP:0011545)2.21369450
85Abnormal ventriculo-arterial connection (HP:0011563)2.21369450
86Asymmetric septal hypertrophy (HP:0001670)2.21318330
87Neoplasm of the oral cavity (HP:0100649)2.20454771
88Atelectasis (HP:0100750)2.20204256
89Intestinal fistula (HP:0100819)2.19631767
90Abnormal hair laboratory examination (HP:0003328)2.18893301
91Supraventricular arrhythmia (HP:0005115)2.18846999
92Rhizomelia (HP:0008905)2.18485282
93Hemivertebrae (HP:0002937)2.17753759
94Platyspondyly (HP:0000926)2.17673639
95Plantar hyperkeratosis (HP:0007556)2.17472935
96Esophageal atresia (HP:0002032)2.13307839
97Spinal muscular atrophy (HP:0007269)2.11886482
98Hyponatremia (HP:0002902)2.10646558
99Lipoatrophy (HP:0100578)2.10474209
100Neonatal short-limb short stature (HP:0008921)2.10438519
101Protuberant abdomen (HP:0001538)2.09858310
102Bronchomalacia (HP:0002780)2.09738600
103Vaginal fistula (HP:0004320)2.07425469
104Hip contracture (HP:0003273)2.07164931
105Hyperglycinuria (HP:0003108)2.06727455
106Dilated cardiomyopathy (HP:0001644)2.06430528
107Bronchitis (HP:0012387)2.05648178
108Abnormality of the dental root (HP:0006486)2.05511328
109Taurodontia (HP:0000679)2.05511328
110Abnormality of permanent molar morphology (HP:0011071)2.05511328
111Partial duplication of thumb phalanx (HP:0009944)2.04431189
112Occipital encephalocele (HP:0002085)2.03960686
113Abnormality of the distal phalanges of the toes (HP:0010182)2.03132315
114Palmoplantar hyperkeratosis (HP:0000972)2.02017271
115Rectal fistula (HP:0100590)2.01584376
116Rectovaginal fistula (HP:0000143)2.01584376
117Truncus arteriosus (HP:0001660)2.01526626
118Aplasia/Hypoplasia of the fovea (HP:0008060)2.00558766
119Hypoplasia of the fovea (HP:0007750)2.00558766
120Recurrent otitis media (HP:0000403)1.99417868
121Hypochromic microcytic anemia (HP:0004840)1.99302333
122Palmoplantar keratoderma (HP:0000982)1.97746328
123Absent forearm bone (HP:0003953)1.96475031
124Aplasia involving forearm bones (HP:0009822)1.96475031
125Abnormal atrioventricular conduction (HP:0005150)1.96428455
126Skin pits (HP:0100276)1.96178172
127Glossoptosis (HP:0000162)1.95046908
128Heart block (HP:0012722)1.93936819
129Sprengel anomaly (HP:0000912)1.93235473
130Centrally nucleated skeletal muscle fibers (HP:0003687)1.92987710
131Flat acetabular roof (HP:0003180)1.92634523
132Distal upper limb amyotrophy (HP:0007149)1.91575443
133Upper limb amyotrophy (HP:0009129)1.91575443
134Genu varum (HP:0002970)1.91285924
135Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91262175
136Fragile nails (HP:0001808)1.90250381
137Milia (HP:0001056)1.90159675
138Abnormality of the labia minora (HP:0012880)1.89388815
139Abnormality of molar (HP:0011077)1.89014411
140Abnormality of molar morphology (HP:0011070)1.89014411
141Distal lower limb amyotrophy (HP:0008944)1.88586228
142Abnormality of the humerus (HP:0003063)1.88214792
143Abnormality of the dental pulp (HP:0006479)1.88065603
144Muscle fiber splitting (HP:0003555)1.87521879
145Vertebral hypoplasia (HP:0008417)1.87247317
146Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87247317
147Palmar hyperkeratosis (HP:0010765)1.87038244
148Short 1st metacarpal (HP:0010034)1.87012004
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87012004
150Rhabdomyosarcoma (HP:0002859)1.86958284
151Renal salt wasting (HP:0000127)1.86127403
152Abnormality of the 1st metacarpal (HP:0010009)1.83775079
153Multifactorial inheritance (HP:0001426)1.82780043
154Glioma (HP:0009733)1.82724073
155Small epiphyses (HP:0010585)1.82095361
156Advanced eruption of teeth (HP:0006288)1.80838402
157Biliary tract neoplasm (HP:0100574)1.80089819
158Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.79889866
159Flattened epiphyses (HP:0003071)1.79617439
160Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79343742
161Abnormality of the upper arm (HP:0001454)1.79209243
162Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79168430
163Carpal bone hypoplasia (HP:0001498)1.78838636
164Obstructive sleep apnea (HP:0002870)1.76961145
165Hypotrichosis (HP:0001006)1.76889729
166Spastic diplegia (HP:0001264)1.76639518
167Synostosis involving bones of the hand (HP:0004278)1.76462759
168Partial duplication of the phalanx of hand (HP:0009999)1.76374604
169Abnormal pancreas size (HP:0012094)1.76371230
170Tubulointerstitial nephritis (HP:0001970)1.76353222
171Abnormality of sodium homeostasis (HP:0010931)1.75648437
172Periauricular skin pits (HP:0100277)1.75376324
173Preauricular pit (HP:0004467)1.75376324
174Ulnar bowing (HP:0003031)1.75234210
175Limited hip movement (HP:0008800)1.75035481
176Absent radius (HP:0003974)1.74364069
177Preauricular skin tag (HP:0000384)1.74031231
178Short ribs (HP:0000773)1.73822266
179Ectopic anus (HP:0004397)1.73548853
180Subaortic stenosis (HP:0001682)1.71827962
181Abnormality of the left ventricular outflow tract (HP:0011103)1.71827962
182Pterygium (HP:0001059)1.71333439
183Pseudobulbar signs (HP:0002200)1.70964024
184Patent foramen ovale (HP:0001655)1.70573012
185Gastrointestinal carcinoma (HP:0002672)1.70034183
186Malignant gastrointestinal tract tumors (HP:0006749)1.70034183
187Dysmetric saccades (HP:0000641)1.68480300
188Atrioventricular block (HP:0001678)1.65917513
189Atrophic scars (HP:0001075)1.65462106
190Abdominal distention (HP:0003270)1.63851876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR28.72272090
2LMTK23.63026456
3CDK123.61691422
4LATS13.39952066
5EPHA23.26994090
6STK38L2.91206147
7SMG12.87112156
8ICK2.63411102
9STK242.14829008
10LATS22.03377924
11TTK1.88181273
12DMPK1.78823960
13MAP3K101.78208022
14FGFR41.70563478
15MYLK1.70114367
16TYRO31.68849180
17AKT31.63560006
18PIK3CA1.58609245
19DYRK1B1.55919265
20NEK11.55587362
21PAK41.52360019
22RIPK11.41052360
23CDC42BPA1.38543598
24GRK61.38439743
25WNK41.36450043
26NEK21.35997573
27TESK11.34729357
28STK31.33637113
29TTN1.32542141
30CDK61.32242869
31NME11.31698166
32CDK71.24565724
33MAPK151.24347433
34PRKCI1.23756842
35MST41.22304274
36RPS6KB21.21569086
37EEF2K1.20415348
38ERBB41.19699683
39MET1.17575611
40BUB11.15124166
41WNK31.13524459
42BMX1.13023714
43MAP3K21.09207875
44STK101.05712038
45TRPM71.02286716
46MTOR0.99807146
47CHEK20.99705308
48EPHB20.96584629
49MARK20.96299692
50PDGFRA0.95048143
51CDC70.93921226
52STK380.90989656
53MATK0.90846136
54YES10.90770268
55TESK20.90117848
56MAP3K60.89781327
57CAMK1G0.85076723
58PLK10.84255415
59BRD40.83669923
60PIM10.81768596
61FGFR10.75870178
62CHEK10.75307667
63MAP3K80.73243462
64RPS6KA20.72023433
65TAOK10.71285305
66PTK20.70395386
67MAPKAPK30.70256027
68PDPK10.70055843
69WEE10.67776108
70OXSR10.67547121
71SIK10.67378656
72AURKB0.66966414
73TRIB30.66880905
74PKN20.64205299
75PLK40.63388528
76PDK30.60668371
77PDK40.60668371
78PRKAA20.60301438
79MAP3K90.59346546
80MAP2K20.58146117
81CSNK1E0.56755364
82ALK0.56620780
83GSK3A0.56445808
84ERBB20.55182902
85CDK40.55057545
86ROCK10.54898429
87WNK10.54400613
88UHMK10.54055200
89PRKG20.53850225
90PTK60.53647155
91PRKAA10.52983597
92AKT20.52841238
93PRKD20.52716660
94CDK20.52710190
95ERN10.52454766
96MUSK0.51240022
97EPHA40.50980540
98OBSCN0.49618420
99RET0.49422321
100MAP3K10.49392584
101MST1R0.49306074
102AURKA0.49224209
103FGFR20.49119005
104STK390.48928132
105MAP3K30.47994345
106MAP2K60.47780469
107FGR0.47432367
108RPS6KA60.46611506
109KSR20.45579360
110CSK0.45208913
111STK40.44767715
112PDK20.44379615
113RPS6KA10.44155814
114LRRK20.42153071
115CAMK1D0.42107026
116SRPK10.41933555
117NEK60.41549845
118PDGFRB0.41509012
119ATM0.40905720
120PAK20.40262723
121MARK30.40103732
122DYRK30.39085008
123CSNK1D0.38378217
124PNCK0.38059200
125PRKD10.37887968
126RPS6KC10.37743246
127RPS6KL10.37743246
128PHKG20.36938910
129PHKG10.36938910
130CAMK40.36811549
131FGFR30.35711897
132FER0.35163011
133PRKD30.35044167
134BCKDK0.34628811
135MAP3K70.33158536
136PAK30.32014652
137EPHB10.31246517
138MAP3K130.25009658
139PRPF4B0.23187736
140BRAF0.22446596

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.61218298
2Dilated cardiomyopathy_Homo sapiens_hsa054142.53212095
3Hippo signaling pathway_Homo sapiens_hsa043902.46315676
4Notch signaling pathway_Homo sapiens_hsa043302.38101451
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28956186
6Basal cell carcinoma_Homo sapiens_hsa052172.24157923
7Protein digestion and absorption_Homo sapiens_hsa049742.10648992
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07703714
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.03642751
10Phenylalanine metabolism_Homo sapiens_hsa003602.02279083
11Lysine degradation_Homo sapiens_hsa003102.01830895
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00468160
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95907417
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.92928395
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.78087358
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72059819
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70161361
18Fatty acid biosynthesis_Homo sapiens_hsa000611.67169430
19One carbon pool by folate_Homo sapiens_hsa006701.64012310
20Adherens junction_Homo sapiens_hsa045201.62377049
21TGF-beta signaling pathway_Homo sapiens_hsa043501.61174646
22Folate biosynthesis_Homo sapiens_hsa007901.59067477
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54994951
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53707405
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53087363
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.50923111
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50279408
28Bladder cancer_Homo sapiens_hsa052191.49156398
29Mismatch repair_Homo sapiens_hsa034301.49103967
30Mineral absorption_Homo sapiens_hsa049781.47776753
31Biosynthesis of amino acids_Homo sapiens_hsa012301.46704734
32RNA transport_Homo sapiens_hsa030131.44547770
33Vitamin digestion and absorption_Homo sapiens_hsa049771.42415612
34Tight junction_Homo sapiens_hsa045301.42389144
35Glutathione metabolism_Homo sapiens_hsa004801.42262412
36Fat digestion and absorption_Homo sapiens_hsa049751.41679863
37Selenocompound metabolism_Homo sapiens_hsa004501.38516488
38Arginine biosynthesis_Homo sapiens_hsa002201.37313069
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34561721
40Hedgehog signaling pathway_Homo sapiens_hsa043401.32889464
41ECM-receptor interaction_Homo sapiens_hsa045121.32355270
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30682303
43Fructose and mannose metabolism_Homo sapiens_hsa000511.29232394
44Bile secretion_Homo sapiens_hsa049761.28876600
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.28424087
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26639725
47Arginine and proline metabolism_Homo sapiens_hsa003301.26528107
48Dorso-ventral axis formation_Homo sapiens_hsa043201.25816511
49Pancreatic secretion_Homo sapiens_hsa049721.24923092
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23593736
51Galactose metabolism_Homo sapiens_hsa000521.21120890
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17006048
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16861128
54Starch and sucrose metabolism_Homo sapiens_hsa005001.16551672
55mRNA surveillance pathway_Homo sapiens_hsa030151.14283638
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14211644
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.12296358
58Tryptophan metabolism_Homo sapiens_hsa003801.11585567
59Tyrosine metabolism_Homo sapiens_hsa003501.09495480
60Nitrogen metabolism_Homo sapiens_hsa009101.07155617
61Glycerophospholipid metabolism_Homo sapiens_hsa005641.06292884
62Cardiac muscle contraction_Homo sapiens_hsa042601.06196976
63Carbon metabolism_Homo sapiens_hsa012001.04230662
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03877227
65MicroRNAs in cancer_Homo sapiens_hsa052061.01664029
66Amoebiasis_Homo sapiens_hsa051461.01019187
67Other glycan degradation_Homo sapiens_hsa005111.01005137
68Fatty acid degradation_Homo sapiens_hsa000710.99793821
69VEGF signaling pathway_Homo sapiens_hsa043700.99486264
70GnRH signaling pathway_Homo sapiens_hsa049120.99264440
71Pyruvate metabolism_Homo sapiens_hsa006200.98789711
72Cell cycle_Homo sapiens_hsa041100.96796195
73Retinol metabolism_Homo sapiens_hsa008300.94200397
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93658341
75Gastric acid secretion_Homo sapiens_hsa049710.93635733
76Insulin signaling pathway_Homo sapiens_hsa049100.93530148
77Choline metabolism in cancer_Homo sapiens_hsa052310.92711117
78Wnt signaling pathway_Homo sapiens_hsa043100.91664423
79Renin-angiotensin system_Homo sapiens_hsa046140.91406569
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91153705
81p53 signaling pathway_Homo sapiens_hsa041150.91092310
82Sulfur metabolism_Homo sapiens_hsa009200.90615789
83Butanoate metabolism_Homo sapiens_hsa006500.88615499
84Insulin resistance_Homo sapiens_hsa049310.88568765
85Sphingolipid metabolism_Homo sapiens_hsa006000.88465232
86Thyroid cancer_Homo sapiens_hsa052160.88242181
87mTOR signaling pathway_Homo sapiens_hsa041500.88054659
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87084639
89DNA replication_Homo sapiens_hsa030300.85198265
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84129888
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82554922
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81990938
93Melanogenesis_Homo sapiens_hsa049160.81472037
94Base excision repair_Homo sapiens_hsa034100.79837195
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79782289
96Inositol phosphate metabolism_Homo sapiens_hsa005620.78625813
97Fatty acid metabolism_Homo sapiens_hsa012120.77280585
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77087120
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76909556
100Small cell lung cancer_Homo sapiens_hsa052220.76531349
101Spliceosome_Homo sapiens_hsa030400.75422233
102Histidine metabolism_Homo sapiens_hsa003400.74683077
103beta-Alanine metabolism_Homo sapiens_hsa004100.73341942
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.71670639
105Propanoate metabolism_Homo sapiens_hsa006400.71034854
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71018603
107Proteoglycans in cancer_Homo sapiens_hsa052050.70656087
108PPAR signaling pathway_Homo sapiens_hsa033200.70467602
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68313211
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.68234642
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.67991024
112AMPK signaling pathway_Homo sapiens_hsa041520.67009609
113Vitamin B6 metabolism_Homo sapiens_hsa007500.66463707
114Axon guidance_Homo sapiens_hsa043600.65861061
115Ovarian steroidogenesis_Homo sapiens_hsa049130.65720689
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65556685
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65527546
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64646783
119Chemical carcinogenesis_Homo sapiens_hsa052040.63897395
120Estrogen signaling pathway_Homo sapiens_hsa049150.63489903
121Hepatitis C_Homo sapiens_hsa051600.63206986
122Chronic myeloid leukemia_Homo sapiens_hsa052200.61923343
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61671875
124Sulfur relay system_Homo sapiens_hsa041220.60463829
125Focal adhesion_Homo sapiens_hsa045100.60323691
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.59938885
127Vibrio cholerae infection_Homo sapiens_hsa051100.58662138
128Pentose phosphate pathway_Homo sapiens_hsa000300.57863252
129Renin secretion_Homo sapiens_hsa049240.57609618
130Salivary secretion_Homo sapiens_hsa049700.56883175
131Glycerolipid metabolism_Homo sapiens_hsa005610.56149711
132Linoleic acid metabolism_Homo sapiens_hsa005910.54989384
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.54020526
134Peroxisome_Homo sapiens_hsa041460.53894131
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53587361
136Glucagon signaling pathway_Homo sapiens_hsa049220.53407236
137Colorectal cancer_Homo sapiens_hsa052100.53183723
138ABC transporters_Homo sapiens_hsa020100.52505586
139Arachidonic acid metabolism_Homo sapiens_hsa005900.52285602
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.50029030
141Pathways in cancer_Homo sapiens_hsa052000.48408909
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48259795
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48211397
144Endometrial cancer_Homo sapiens_hsa052130.46521038
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46337967
146Systemic lupus erythematosus_Homo sapiens_hsa053220.46235649
147Viral carcinogenesis_Homo sapiens_hsa052030.45461630
148Thyroid hormone synthesis_Homo sapiens_hsa049180.44957607
149ErbB signaling pathway_Homo sapiens_hsa040120.44953949
150Prostate cancer_Homo sapiens_hsa052150.44416544
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42570438
152Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42306902

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