B4GALT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85469896
2desmosome organization (GO:0002934)3.66014095
3cell adhesion mediated by integrin (GO:0033627)3.45495340
4hemidesmosome assembly (GO:0031581)3.38075960
5neutrophil activation involved in immune response (GO:0002283)3.37623993
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28583139
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.28583139
8membrane raft organization (GO:0031579)3.25292544
9negative regulation of phagocytosis (GO:0050765)3.22807132
10positive regulation of gamma-delta T cell activation (GO:0046645)3.20242662
11skin morphogenesis (GO:0043589)3.15330853
12antigen processing and presentation of endogenous antigen (GO:0019883)3.12053514
13regulation of vitamin D biosynthetic process (GO:0060556)3.06662141
14positive regulation of interferon-alpha production (GO:0032727)3.05956874
15Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05392686
16modulation by symbiont of host immune response (GO:0052553)2.98484135
17positive regulation by symbiont of host defense response (GO:0052509)2.98484135
18modulation by symbiont of host defense response (GO:0052031)2.98484135
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.98484135
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.98484135
21positive regulation by organism of defense response of other organism involved in symbiotic interact2.98484135
22regulation of interferon-beta biosynthetic process (GO:0045357)2.93419824
23hepatocyte apoptotic process (GO:0097284)2.91528895
24regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.90982715
25response to peptidoglycan (GO:0032494)2.90492761
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88342920
27regulation of cytokine secretion involved in immune response (GO:0002739)2.87992073
28regulation of interferon-alpha production (GO:0032647)2.87451215
29positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.87106777
30pinocytosis (GO:0006907)2.85395222
31regulation of membrane protein ectodomain proteolysis (GO:0051043)2.82619462
32negative regulation of granulocyte differentiation (GO:0030853)2.82363408
33decidualization (GO:0046697)2.77968484
34regulation of vitamin metabolic process (GO:0030656)2.74844359
35regulation of metalloenzyme activity (GO:0048552)2.74454937
36positive regulation of extracellular matrix organization (GO:1903055)2.71234113
37regulation of interleukin-12 biosynthetic process (GO:0045075)2.70925308
38reactive oxygen species biosynthetic process (GO:1903409)2.70895916
39detection of molecule of bacterial origin (GO:0032490)2.70727614
40immunoglobulin mediated immune response (GO:0016064)2.69399082
41hydrogen peroxide biosynthetic process (GO:0050665)2.67896760
42macrophage activation involved in immune response (GO:0002281)2.65201711
43positive regulation of natural killer cell differentiation (GO:0032825)2.64306208
44lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60776712
45neutrophil activation (GO:0042119)2.60560616
46regulation of T-helper 1 cell differentiation (GO:0045625)2.60258295
47protein localization to endosome (GO:0036010)2.59962076
48response to muramyl dipeptide (GO:0032495)2.59472718
49leukocyte aggregation (GO:0070486)2.58871222
50positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58407885
51production of molecular mediator involved in inflammatory response (GO:0002532)2.56290985
52positive regulation of p38MAPK cascade (GO:1900745)2.55562978
53regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.54369038
54bundle of His cell to Purkinje myocyte communication (GO:0086069)2.52849117
55definitive hemopoiesis (GO:0060216)2.51622388
56COPI coating of Golgi vesicle (GO:0048205)2.50938363
57Golgi transport vesicle coating (GO:0048200)2.50938363
58positive regulation of chemokine biosynthetic process (GO:0045080)2.48370406
59positive regulation of macrophage differentiation (GO:0045651)2.45489745
60positive regulation of B cell differentiation (GO:0045579)2.45344292
61* regulation of apoptotic process involved in morphogenesis (GO:1902337)2.42724539
62cellular response to zinc ion (GO:0071294)2.41906443
63positive regulation of interferon-beta production (GO:0032728)2.41035293
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39781209
65granulocyte activation (GO:0036230)2.38567599
66regulation of T-helper 2 cell differentiation (GO:0045628)2.37495828
67endodermal cell differentiation (GO:0035987)2.37127079
68regulation of chemokine biosynthetic process (GO:0045073)2.35955107
69response to fungus (GO:0009620)2.35158760
70positive regulation of antigen processing and presentation (GO:0002579)2.34964269
71negative regulation of cytokine production involved in immune response (GO:0002719)2.34786406
72regulation of gamma-delta T cell activation (GO:0046643)2.34324962
73response to interferon-alpha (GO:0035455)2.32662299
74regulation of interleukin-8 biosynthetic process (GO:0045414)2.32406234
75regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.32236860
76negative regulation of nitric oxide biosynthetic process (GO:0045019)2.30979083
77sphingosine metabolic process (GO:0006670)2.30909809
78NIK/NF-kappaB signaling (GO:0038061)2.29926990
79regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.29882550
80positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.29428130
81respiratory burst (GO:0045730)2.28747025
82response to type I interferon (GO:0034340)2.28338787
83response to interferon-beta (GO:0035456)2.28304091
84keratan sulfate catabolic process (GO:0042340)2.27928635
85peptide catabolic process (GO:0043171)2.27815701
86regulation of transforming growth factor beta1 production (GO:0032908)2.27706003
87regulation of antigen processing and presentation (GO:0002577)2.27205347
88regulation of B cell receptor signaling pathway (GO:0050855)2.27136842
89regulation of gamma-delta T cell differentiation (GO:0045586)2.25949900
90regulation of B cell differentiation (GO:0045577)2.25830658
91branching involved in labyrinthine layer morphogenesis (GO:0060670)2.24478828
92positive regulation of tumor necrosis factor production (GO:0032760)2.24210916
93negative regulation of protein autophosphorylation (GO:0031953)2.24084242
94negative regulation of lipid storage (GO:0010888)2.23630228
95wound healing, spreading of epidermal cells (GO:0035313)2.23495688
96type I interferon signaling pathway (GO:0060337)2.23253067
97cellular response to type I interferon (GO:0071357)2.23253067
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.22068860
99superoxide anion generation (GO:0042554)2.21899403
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.21827338
101response to host immune response (GO:0052572)2.21827338
102dendritic cell chemotaxis (GO:0002407)2.21154712
103negative regulation of interleukin-12 production (GO:0032695)2.20931378
104interferon-gamma secretion (GO:0072643)2.20416142
105interferon-gamma-mediated signaling pathway (GO:0060333)2.19182810
106regulation of interleukin-8 secretion (GO:2000482)2.19182134
107iron ion import (GO:0097286)2.18381901
108embryonic process involved in female pregnancy (GO:0060136)2.17291482
109positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.16956402
110response to laminar fluid shear stress (GO:0034616)2.16805561
111substrate-dependent cell migration (GO:0006929)2.16473610
112regulation of heterotypic cell-cell adhesion (GO:0034114)2.16348039
113positive regulation of type 2 immune response (GO:0002830)2.16049403
114regulation of macrophage cytokine production (GO:0010935)2.15327897
115hyaluronan catabolic process (GO:0030214)2.15114893
116positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.14962375
117cellular extravasation (GO:0045123)2.14666035
118response to host (GO:0075136)2.14550128
119response to host defenses (GO:0052200)2.14550128
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.14550128
121regulation of mononuclear cell migration (GO:0071675)2.14532102
122platelet-derived growth factor receptor signaling pathway (GO:0048008)2.14241675
123positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.12697079
124regulation of chemokine secretion (GO:0090196)2.12505667
125actin nucleation (GO:0045010)2.12502692
126B cell mediated immunity (GO:0019724)2.11841891
127dendritic cell migration (GO:0036336)2.11741238
128detection of external biotic stimulus (GO:0098581)2.11215141
129positive regulation of chemokine secretion (GO:0090197)2.11069852
130regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.10929656
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.10253856
132regulation of extracellular matrix disassembly (GO:0010715)2.10155855
133positive regulation of reactive oxygen species metabolic process (GO:2000379)2.10118396
134dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.09615257
135regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.09577673
136ER overload response (GO:0006983)2.09100376
137positive regulation of T cell chemotaxis (GO:0010820)2.09016152
138regulation of T cell chemotaxis (GO:0010819)2.09016152
139diol metabolic process (GO:0034311)2.08333750
140regulation of dendritic cell antigen processing and presentation (GO:0002604)2.07802711
141establishment of endothelial barrier (GO:0061028)2.07781654
142surfactant homeostasis (GO:0043129)2.07404496
143defense response to fungus (GO:0050832)2.07055130
144myeloid dendritic cell activation (GO:0001773)2.06798975
145negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.06752015
146regulation of podosome assembly (GO:0071801)2.06514483
147regulation of integrin-mediated signaling pathway (GO:2001044)2.06248443
148cellular response to interferon-alpha (GO:0035457)2.05879975
149positive regulation of protein import into nucleus, translocation (GO:0033160)2.05711386
150regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.05462531
151leukocyte cell-cell adhesion (GO:0007159)2.05200883
152modulation of growth of symbiont involved in interaction with host (GO:0044144)2.05170148
153regulation of growth of symbiont in host (GO:0044126)2.05170148
154negative regulation of growth of symbiont in host (GO:0044130)2.05170148
155negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.05170148
156regulation of superoxide anion generation (GO:0032928)2.05043974
157positive regulation of endothelial cell apoptotic process (GO:2000353)2.04278153
158negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.04138565
159T-helper 1 type immune response (GO:0042088)2.02660941
160response to vitamin D (GO:0033280)2.01041876
161type B pancreatic cell proliferation (GO:0044342)2.00900964
162negative regulation of fibrinolysis (GO:0051918)2.00855524
163adhesion of symbiont to host (GO:0044406)2.00671116
164negative regulation of viral entry into host cell (GO:0046597)2.00360025
165response to progesterone (GO:0032570)2.00174759
166negative regulation of complement activation (GO:0045916)1.99141218
167sphingoid metabolic process (GO:0046519)1.98391416
168positive regulation of chemokine production (GO:0032722)1.97593275
169positive regulation of NF-kappaB import into nucleus (GO:0042346)1.97190302
170negative regulation of protein activation cascade (GO:2000258)1.96301685
171cell-substrate junction assembly (GO:0007044)1.95956188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.15057707
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.06699027
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.73649287
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.73470932
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.40866336
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.25362115
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.19417536
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.17469712
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02311587
10* ESR2_21235772_ChIP-Seq_MCF-7_Human2.61964889
11* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54496717
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52514186
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52268575
14* IRF8_27001747_Chip-Seq_BMDM_Mouse2.41941833
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41867017
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.36989519
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36771000
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.35760772
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30343010
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.27056084
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22959684
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.19237774
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18940823
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17881770
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15879581
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01965569
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96517471
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93133447
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.89959441
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89411198
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.88090611
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88061232
33SCL_19346495_ChIP-Seq_HPC-7_Human1.85607553
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.85564874
35MYB_26560356_Chip-Seq_TH2_Human1.78879442
36MAF_26560356_Chip-Seq_TH1_Human1.69719455
37* SPI1_23547873_ChIP-Seq_NB4_Human1.68016375
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66555886
39VDR_21846776_ChIP-Seq_THP-1_Human1.66488815
40CLOCK_20551151_ChIP-Seq_293T_Human1.65766603
41MYC_22102868_ChIP-Seq_BL_Human1.61799050
42GATA1_22025678_ChIP-Seq_K562_Human1.60755526
43ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60142787
44RUNX_20019798_ChIP-Seq_JUKART_Human1.59443108
45MYB_26560356_Chip-Seq_TH1_Human1.57415703
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55802667
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54389443
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53560682
49* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52304908
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51863599
51* VDR_24763502_ChIP-Seq_THP-1_Human1.51202332
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51085228
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44818079
54* RUNX1_22412390_ChIP-Seq_EML_Mouse1.44708284
55* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43651174
56RACK7_27058665_Chip-Seq_MCF-7_Human1.43252559
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42525758
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40500156
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39187110
60PU_27001747_Chip-Seq_BMDM_Mouse1.35814384
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.35595630
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34663731
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34663731
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34554695
65* ESR1_21235772_ChIP-Seq_MCF-7_Human1.34114673
66ATF3_27146783_Chip-Seq_COLON_Human1.31379401
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.30931176
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30202868
69* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29141402
70* UTX_26944678_Chip-Seq_JUKART_Human1.28513212
71BRD4_25478319_ChIP-Seq_HGPS_Human1.27399619
72* GATA2_21666600_ChIP-Seq_HMVEC_Human1.26619052
73* RXR_22158963_ChIP-Seq_LIVER_Mouse1.24720026
74* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23618710
75AHR_22903824_ChIP-Seq_MCF-7_Human1.23329413
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22568117
77SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21797835
78TCF7_22412390_ChIP-Seq_EML_Mouse1.21545166
79* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17207215
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17096213
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16560409
82UBF1/2_26484160_Chip-Seq_HMECs_Human1.15499898
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13934071
84* GATA4_25053715_ChIP-Seq_YYC3_Human1.11604440
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11266140
86GATA6_25053715_ChIP-Seq_YYC3_Human1.10809214
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09791716
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08877450
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08770776
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08130736
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06792846
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06736269
93* GATA3_24758297_ChIP-Seq_MCF-7_Human1.06463023
94* LXR_22158963_ChIP-Seq_LIVER_Mouse1.06327535
95* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05247083
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05180048
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03805370
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03122684
99ZNF263_19887448_ChIP-Seq_K562_Human1.02978758
100VDR_24787735_ChIP-Seq_THP-1_Human1.02612615
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02105264
102ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01938257
103* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01912492
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01481544
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00191850
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00124644
107* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99972816
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99671601
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99352647
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99056244
111SPI1_23127762_ChIP-Seq_K562_Human0.97776557
112* TP63_23658742_ChIP-Seq_EP156T_Human0.96905053
113* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96829476
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96760268
115* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95370483
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.95041725
117* FOXO3_23340844_ChIP-Seq_DLD1_Human0.94035150
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93538551
119* SOX2_20726797_ChIP-Seq_SW620_Human0.93339577
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92697797
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92622732
122FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92330666
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92267573
124TP53_18474530_ChIP-ChIP_U2OS_Human0.91323800
125* MAF_26560356_Chip-Seq_TH2_Human0.90040435
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.89961738
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.89961738
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89773208
129* NCOR1_26117541_ChIP-Seq_K562_Human0.89552540
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.88984680
131* CJUN_26792858_Chip-Seq_BT549_Human0.88843343
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88830614
133HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87540688
134P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87268412
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86120671
136* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85343583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.32289517
2MP0001835_abnormal_antigen_presentation2.59098483
3MP0003436_decreased_susceptibility_to2.52566854
4MP0003950_abnormal_plasma_membrane2.35273162
5MP0005275_abnormal_skin_tensile2.30097092
6MP0006054_spinal_hemorrhage2.22655015
7MP0003705_abnormal_hypodermis_morpholog2.14259252
8MP0009785_altered_susceptibility_to2.04923190
9MP0002166_altered_tumor_susceptibility2.00861241
10MP0010234_abnormal_vibrissa_follicle1.95244713
11MP0002139_abnormal_hepatobiliary_system1.94461925
12MP0003566_abnormal_cell_adhesion1.93055443
13* MP0002148_abnormal_hypersensitivity_rea1.87929364
14MP0003279_aneurysm1.86793376
15* MP0002419_abnormal_innate_immunity1.83644300
16MP0002396_abnormal_hematopoietic_system1.82201807
17MP0003300_gastrointestinal_ulcer1.78516508
18MP0003724_increased_susceptibility_to1.76856957
19MP0010352_gastrointestinal_tract_polyps1.76280923
20MP0005025_abnormal_response_to1.70579014
21MP0005000_abnormal_immune_tolerance1.70001336
22MP0005503_abnormal_tendon_morphology1.69897097
23MP0002006_tumorigenesis1.65551509
24MP0000685_abnormal_immune_system1.65538398
25MP0003303_peritoneal_inflammation1.64820088
26* MP0002452_abnormal_antigen_presenting1.63760738
27MP0001790_abnormal_immune_system1.59051883
28MP0005387_immune_system_phenotype1.59051883
29MP0001800_abnormal_humoral_immune1.56381162
30MP0008004_abnormal_stomach_pH1.55991766
31MP0001533_abnormal_skeleton_physiology1.54187243
32MP0005671_abnormal_response_to1.53210808
33* MP0005023_abnormal_wound_healing1.51065773
34MP0010155_abnormal_intestine_physiology1.51023732
35MP0003195_calcinosis1.50755472
36MP0002405_respiratory_system_inflammati1.47232991
37* MP0001881_abnormal_mammary_gland1.47069859
38MP0005464_abnormal_platelet_physiology1.43957170
39MP0000858_altered_metastatic_potential1.43822659
40MP0010368_abnormal_lymphatic_system1.43299916
41MP0002877_abnormal_melanocyte_morpholog1.42898014
42* MP0002420_abnormal_adaptive_immunity1.42894255
43MP0000343_altered_response_to1.42640501
44* MP0001819_abnormal_immune_cell1.42038408
45MP0002009_preneoplasia1.40778633
46MP0002723_abnormal_immune_serum1.39663868
47MP0005360_urolithiasis1.39088523
48MP0005257_abnormal_intraocular_pressure1.39086558
49MP0003448_altered_tumor_morphology1.37549305
50MP0003763_abnormal_thymus_physiology1.36340871
51MP0001958_emphysema1.35469501
52MP0005397_hematopoietic_system_phenotyp1.35421809
53MP0001545_abnormal_hematopoietic_system1.35421809
54MP0002060_abnormal_skin_morphology1.31954951
55MP0004808_abnormal_hematopoietic_stem1.30441980
56MP0006082_CNS_inflammation1.27840845
57MP0003191_abnormal_cellular_cholesterol1.27700781
58MP0003828_pulmonary_edema1.26523811
59MP0009333_abnormal_splenocyte_physiolog1.26037514
60* MP0001845_abnormal_inflammatory_respons1.24544661
61MP0003075_altered_response_to1.21504132
62MP0004947_skin_inflammation1.21402036
63MP0005076_abnormal_cell_differentiation1.21351855
64MP0001853_heart_inflammation1.20341581
65MP0005451_abnormal_body_composition1.17261245
66* MP0002398_abnormal_bone_marrow1.15723574
67* MP0001216_abnormal_epidermal_layer1.14687026
68MP0000465_gastrointestinal_hemorrhage1.13938406
69MP0000767_abnormal_smooth_muscle1.13564630
70MP0005165_increased_susceptibility_to1.12194510
71MP0005390_skeleton_phenotype1.11174560
72* MP0000716_abnormal_immune_system1.10786901
73MP0005058_abnormal_lysosome_morphology1.10443466
74MP0004264_abnormal_extraembryonic_tissu1.10370254
75MP0002933_joint_inflammation1.10075853
76MP0009278_abnormal_bone_marrow1.09635584
77MP0001879_abnormal_lymphatic_vessel1.08650567
78MP0002132_abnormal_respiratory_system1.08478386
79MP0002295_abnormal_pulmonary_circulatio1.08242457
80MP0002998_abnormal_bone_remodeling1.07605039
81* MP0000689_abnormal_spleen_morphology1.07514908
82MP0005166_decreased_susceptibility_to1.07494972
83MP0001873_stomach_inflammation1.07095510
84* MP0000490_abnormal_crypts_of1.05874542
85MP0004782_abnormal_surfactant_physiolog1.03826102
86MP0009780_abnormal_chondrocyte_physiolo1.02684400
87* MP0002722_abnormal_immune_system1.02230177
88MP0002796_impaired_skin_barrier1.01880583
89MP0010678_abnormal_skin_adnexa1.01309232
90MP0003186_abnormal_redox_activity1.00956924
91MP0008469_abnormal_protein_level0.99967029
92* MP0002429_abnormal_blood_cell0.98812043
93MP0009764_decreased_sensitivity_to0.96910268
94MP0002896_abnormal_bone_mineralization0.96895126
95MP0002168_other_aberrant_phenotype0.94987593
96MP0005083_abnormal_biliary_tract0.94506995
97MP0003941_abnormal_skin_development0.94504061
98MP0004272_abnormal_basement_membrane0.93848007
99MP0009840_abnormal_foam_cell0.93579291
100MP0003045_fibrosis0.92564717
101MP0003453_abnormal_keratinocyte_physiol0.90141857
102MP0005623_abnormal_meninges_morphology0.89858665
103MP0008007_abnormal_cellular_replicative0.89520299
104MP0001243_abnormal_dermal_layer0.87376303
105MP0010307_abnormal_tumor_latency0.86338519
106MP0002876_abnormal_thyroid_physiology0.86007655
107MP0001542_abnormal_bone_strength0.84980191
108MP0000249_abnormal_blood_vessel0.82485614
109MP0003795_abnormal_bone_structure0.81518396
110MP0001915_intracranial_hemorrhage0.81108713
111MP0003091_abnormal_cell_migration0.80466052
112MP0005164_abnormal_response_to0.79119595
113MP0003183_abnormal_peptide_metabolism0.78083776
114MP0004510_myositis0.77346604
115MP0004233_abnormal_muscle_weight0.77008053
116* MP0000627_abnormal_mammary_gland0.76840276
117MP0009384_cardiac_valve_regurgitation0.76303611
118MP0003172_abnormal_lysosome_physiology0.75345048
119MP0009763_increased_sensitivity_to0.73202380
120MP0002254_reproductive_system_inflammat0.73012201
121MP0001851_eye_inflammation0.72821137
122MP0009053_abnormal_anal_canal0.71378906
123MP0002019_abnormal_tumor_incidence0.70084859
124MP0005508_abnormal_skeleton_morphology0.69972080
125MP0003567_abnormal_fetal_cardiomyocyte0.69639846
126MP0004883_abnormal_blood_vessel0.67893914
127MP0002138_abnormal_hepatobiliary_system0.67542220

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.97772660
2Abnormality of glycolipid metabolism (HP:0010969)3.88936709
3Abnormality of liposaccharide metabolism (HP:0010968)3.88936709
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.88936709
5Recurrent abscess formation (HP:0002722)3.67993598
6Recurrent bacterial skin infections (HP:0005406)3.26281374
7Protrusio acetabuli (HP:0003179)3.15033858
8Osteolytic defects of the phalanges of the hand (HP:0009771)3.13450406
9Osteolytic defects of the hand bones (HP:0009699)3.13450406
10Myositis (HP:0100614)3.09580811
11Systemic lupus erythematosus (HP:0002725)3.06278282
12Dysostosis multiplex (HP:0000943)3.02729474
13Vascular calcification (HP:0004934)2.91189082
14Vascular tortuosity (HP:0004948)2.90264259
15Urinary glycosaminoglycan excretion (HP:0003541)2.85425047
16Mucopolysacchariduria (HP:0008155)2.85425047
17Arterial tortuosity (HP:0005116)2.85077432
18Abnormality of mucopolysaccharide metabolism (HP:0011020)2.79764329
19Abnormality of polysaccharide metabolism (HP:0011012)2.79764329
20Abnormality of glycosaminoglycan metabolism (HP:0004371)2.79764329
21Autoimmune thrombocytopenia (HP:0001973)2.78155276
22Premature rupture of membranes (HP:0001788)2.77123048
23Recurrent gram-negative bacterial infections (HP:0005420)2.76307239
24Orchitis (HP:0100796)2.75420357
25Spinal cord lesions (HP:0100561)2.74892085
26Syringomyelia (HP:0003396)2.74892085
27Pustule (HP:0200039)2.74655570
28Aortic dissection (HP:0002647)2.71384524
29Aortic aneurysm (HP:0004942)2.63102866
30Periodontitis (HP:0000704)2.61997672
31Cellulitis (HP:0100658)2.59724724
32Spontaneous hematomas (HP:0007420)2.54034472
33Cervical subluxation (HP:0003308)2.49108147
34Myocardial infarction (HP:0001658)2.48072523
35Elevated erythrocyte sedimentation rate (HP:0003565)2.46541918
36Abnormality of macrophages (HP:0004311)2.45644818
37Alopecia of scalp (HP:0002293)2.43586699
38Vertebral compression fractures (HP:0002953)2.41940701
39Vacuolated lymphocytes (HP:0001922)2.40747794
40Recurrent fungal infections (HP:0002841)2.38254365
41Right ventricular cardiomyopathy (HP:0011663)2.37450661
42Keratoconjunctivitis sicca (HP:0001097)2.35019510
43Recurrent viral infections (HP:0004429)2.29990439
44Milia (HP:0001056)2.28054433
45Thrombocytosis (HP:0001894)2.27944635
46Ovoid vertebral bodies (HP:0003300)2.27600984
47Amyloidosis (HP:0011034)2.26866436
48Cerebral aneurysm (HP:0004944)2.25596204
49Gingivitis (HP:0000230)2.25189135
50Atrophic scars (HP:0001075)2.24382951
51Retrobulbar optic neuritis (HP:0100654)2.23517296
52Optic neuritis (HP:0100653)2.23517296
53Hematochezia (HP:0002573)2.22777968
54Onycholysis (HP:0001806)2.21562964
55Mediastinal lymphadenopathy (HP:0100721)2.21519003
56Nonimmune hydrops fetalis (HP:0001790)2.20723360
57Petechiae (HP:0000967)2.19000382
58Glomerulonephritis (HP:0000099)2.18060593
59Interstitial pulmonary disease (HP:0006530)2.16810243
60Peritonitis (HP:0002586)2.16555639
61Abnormal platelet volume (HP:0011876)2.16152287
62Osteomyelitis (HP:0002754)2.15630322
63Arterial thrombosis (HP:0004420)2.14502979
64Nephritis (HP:0000123)2.14249139
65Nuclear cataract (HP:0100018)2.10829125
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06510838
67Keratoconjunctivitis (HP:0001096)2.06323123
68Plantar hyperkeratosis (HP:0007556)2.05579875
69Axonal loss (HP:0003447)2.03372534
70Prolonged bleeding time (HP:0003010)2.02280556
71IgM deficiency (HP:0002850)2.01938117
72Asymmetry of the thorax (HP:0001555)2.01937975
73Hypoplasia of the odontoid process (HP:0003311)1.99532979
74Malnutrition (HP:0004395)1.99032751
75Recurrent skin infections (HP:0001581)1.97468238
76Increased mean platelet volume (HP:0011877)1.96852050
77Abnormality of complement system (HP:0005339)1.96795964
78Dilatation of the ascending aorta (HP:0005111)1.96761530
79Ankle contracture (HP:0006466)1.96221517
80Eosinophilia (HP:0001880)1.92504740
81Meningitis (HP:0001287)1.91813611
82Skin ulcer (HP:0200042)1.90924271
83Abnormal platelet function (HP:0011869)1.88893675
84Impaired platelet aggregation (HP:0003540)1.88893675
85Flared iliac wings (HP:0002869)1.88257504
86Reduced subcutaneous adipose tissue (HP:0003758)1.88251267
87Natal tooth (HP:0000695)1.87659147
88Pulmonary artery stenosis (HP:0004415)1.87342587
89Abnormality of the odontoid process (HP:0003310)1.86842041
90Joint stiffness (HP:0001387)1.86568230
91Nail dystrophy (HP:0008404)1.85750136
92Increased serum ferritin (HP:0003281)1.84746665
93Epistaxis (HP:0000421)1.83195239
94Elbow flexion contracture (HP:0002987)1.83160297
95Loss of speech (HP:0002371)1.82756401
96Spondylolisthesis (HP:0003302)1.82677823
97Complement deficiency (HP:0004431)1.82575345
98Increased connective tissue (HP:0009025)1.82432824
99Leukocytosis (HP:0001974)1.81847847
100Emphysema (HP:0002097)1.81717783
101Granulocytopenia (HP:0001913)1.81132927
102Femoral bowing (HP:0002980)1.80744254
103Gingival bleeding (HP:0000225)1.80479297
104Abnormality of carpal bone ossification (HP:0006257)1.80104138
105Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79991376
106Aneurysm (HP:0002617)1.79193319
107Blue sclerae (HP:0000592)1.78838195
108Vasculitis (HP:0002633)1.78486197
109Flat acetabular roof (HP:0003180)1.77634936
110Obstructive lung disease (HP:0006536)1.77213500
111Chronic obstructive pulmonary disease (HP:0006510)1.77213500
112Abnormality of the acetabulum (HP:0003170)1.75669217
113Distal lower limb muscle weakness (HP:0009053)1.75622886
114Thin bony cortex (HP:0002753)1.75088120
115Soft skin (HP:0000977)1.74167392
116Pulmonary infiltrates (HP:0002113)1.73489422
117Hypoplasia of dental enamel (HP:0006297)1.72578078
118Fragile skin (HP:0001030)1.71233362
119Short nail (HP:0001799)1.70513433
120Tibial bowing (HP:0002982)1.69114695
121Abnormality of T cell physiology (HP:0011840)1.68710611
122Lip pit (HP:0100267)1.67745212
123Biconcave vertebral bodies (HP:0004586)1.67702560
124Abnormality of the pericardium (HP:0001697)1.66838098
125Follicular hyperkeratosis (HP:0007502)1.66554211
126Subacute progressive viral hepatitis (HP:0006572)1.66067721
127Thick nail (HP:0001805)1.65563550
128Coxa vara (HP:0002812)1.65308854
129Chronic diarrhea (HP:0002028)1.65159652
130Mitral stenosis (HP:0001718)1.64583483
131Fragile nails (HP:0001808)1.64549451
132Aortic regurgitation (HP:0001659)1.64342732
133Sparse eyelashes (HP:0000653)1.63337804
134Recurrent bronchitis (HP:0002837)1.62957586
135Abnormality of the distal phalanges of the toes (HP:0010182)1.62741057
136Glucose intolerance (HP:0000833)1.61705465
137Cardiovascular calcification (HP:0011915)1.61604571
138Increased neuronal autofluorescent lipopigment (HP:0002074)1.61501272
139Chronic otitis media (HP:0000389)1.61498641
140Gastrointestinal infarctions (HP:0005244)1.61074786
141Abnormality of T cell number (HP:0011839)1.60959125
142Abnormality of nail color (HP:0100643)1.60887224
143Wormian bones (HP:0002645)1.60491454
144Popliteal pterygium (HP:0009756)1.60089168
145Abnormality of T cells (HP:0002843)1.59677748
146Abnormal foot bone ossification (HP:0010675)1.59123144
147Abnormality of the common coagulation pathway (HP:0010990)1.58782739
148J-shaped sella turcica (HP:0002680)1.57429486
149Hemoptysis (HP:0002105)1.57167461
150Basal ganglia calcification (HP:0002135)1.56819943
151Urticaria (HP:0001025)1.56107904
152Increased cerebral lipofuscin (HP:0011813)1.55959131
153Bone cyst (HP:0012062)1.55638022

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K142.82730249
2TGFBR22.60439959
3ERN12.41587186
4MAP4K12.19177786
5TYK22.07883428
6PKN22.03582434
7JAK32.00521780
8IRAK41.97777080
9STK101.97413476
10TRPM71.96942611
11NEK91.94005821
12SIK31.88450427
13MAP3K121.86662354
14DDR21.84720278
15NME21.81754386
16IRAK31.76096743
17PIM21.75078829
18TBK11.72634755
19MAP2K31.71038779
20ZAP701.67250281
21TRIB31.63611914
22PIM11.56731617
23IKBKE1.56132965
24MAP3K31.55265452
25IKBKB1.49294995
26MET1.47969460
27TXK1.47712998
28PTK21.47329114
29BLK1.43903585
30MAP3K131.43601608
31KIT1.42783821
32ZAK1.42425602
33RPS6KA41.42331589
34LRRK21.42196798
35JAK11.37910431
36FGFR31.36579928
37TTN1.36484784
38PRKD21.32114342
39BMPR21.32083077
40EEF2K1.31067546
41PRPF4B1.28171298
42BTK1.27646261
43TEC1.27053423
44EPHA31.26960763
45ARAF1.25473476
46STK241.22143656
47CHUK1.21895589
48SIK11.21222033
49FER1.20176972
50TAOK21.19723587
51STK41.19645328
52FGFR41.19545992
53CDC42BPA1.18754738
54CDK61.17608441
55CLK11.14473163
56FLT31.13719944
57FRK1.13620017
58MAP3K21.12571029
59CSF1R1.12126542
60MST41.12004155
61MAP3K101.09424806
62LMTK21.08218052
63MUSK1.08072415
64GRK71.07327970
65STK31.06979408
66CDK121.05748945
67ABL21.04230076
68CSK1.03501260
69ERBB30.98409907
70EPHB10.96715981
71MAPKAPK30.95956152
72TGFBR10.95096325
73MELK0.94334361
74NLK0.94263309
75LATS20.93834953
76PTK60.93448446
77ITK0.93419639
78TESK10.91217753
79MAP3K90.91073621
80MOS0.90917923
81LIMK10.90779080
82SMG10.89709285
83KDR0.89114339
84MYLK0.88929932
85RIPK10.85345731
86STK380.83281058
87RPS6KB20.82771600
88PAK40.81231675
89HCK0.80300578
90MAP3K10.76859802
91EIF2AK20.71834421
92BMX0.71644872
93RPS6KA60.71183458
94GRK60.70020097
95JAK20.69702228
96AKT30.69173537
97RPS6KC10.66265094
98RPS6KL10.66265094
99LCK0.65989802
100EIF2AK10.65801143
101CAMK1D0.65727224
102SYK0.65063808
103MAPKAPK20.64687015
104CDK40.63498766
105PIK3CA0.63492031
106LATS10.62740875
107LYN0.60256139
108EPHB20.59750781
109EPHA20.59212126
110GRK10.56073013
111HIPK20.56032793
112MST1R0.55766129
113BCKDK0.55057120
114ILK0.53981335
115PDGFRB0.53182687
116MAP3K80.52996409
117MATK0.51945487
118RIPK40.51625350
119MARK30.51520950
120NUAK10.51419311
121MAP2K10.50476797
122PIK3CG0.48758193
123IRAK10.48587060
124TAOK30.47188679
125PDGFRA0.46024925
126MAPK70.45626456
127TIE10.44944550
128CDK90.43930383
129PRKCI0.43915946
130ADRBK20.42815502
131PLK40.41986041
132PDK20.41035734
133ABL10.40793906
134PDPK10.39807591
135GSK3A0.39804287
136PRKG20.39759450
137PRKD10.39431507
138PAK20.38674255
139MAPK110.38546874
140CDK70.38427185
141EIF2AK30.38094079
142ACVR1B0.36691975
143MAP3K110.36630370

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.87282594
2Leishmaniasis_Homo sapiens_hsa051402.46644327
3Staphylococcus aureus infection_Homo sapiens_hsa051502.32562304
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.02365886
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87945739
6Intestinal immune network for IgA production_Homo sapiens_hsa046721.82665264
7Sulfur metabolism_Homo sapiens_hsa009201.82394462
8Legionellosis_Homo sapiens_hsa051341.82110543
9Measles_Homo sapiens_hsa051621.75832908
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74060654
11Osteoclast differentiation_Homo sapiens_hsa043801.68219197
12Toxoplasmosis_Homo sapiens_hsa051451.63092197
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62372656
14Malaria_Homo sapiens_hsa051441.57100606
15Antigen processing and presentation_Homo sapiens_hsa046121.53607040
16Pertussis_Homo sapiens_hsa051331.46553242
17Primary immunodeficiency_Homo sapiens_hsa053401.44534129
18Herpes simplex infection_Homo sapiens_hsa051681.41687949
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.39386205
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.36448825
21Viral myocarditis_Homo sapiens_hsa054161.35086346
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34138860
23Small cell lung cancer_Homo sapiens_hsa052221.33986495
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33614628
25TNF signaling pathway_Homo sapiens_hsa046681.33599646
26Hematopoietic cell lineage_Homo sapiens_hsa046401.33552444
27Influenza A_Homo sapiens_hsa051641.32001888
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30320602
29African trypanosomiasis_Homo sapiens_hsa051431.29185432
30Other glycan degradation_Homo sapiens_hsa005111.28603958
31Apoptosis_Homo sapiens_hsa042101.26715329
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26529882
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20616732
34B cell receptor signaling pathway_Homo sapiens_hsa046621.20284998
35Graft-versus-host disease_Homo sapiens_hsa053321.20142002
36Tuberculosis_Homo sapiens_hsa051521.17723026
37Complement and coagulation cascades_Homo sapiens_hsa046101.17308509
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17264165
39ECM-receptor interaction_Homo sapiens_hsa045121.15718312
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.15682047
41Sphingolipid metabolism_Homo sapiens_hsa006001.14751445
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12937836
43Fatty acid biosynthesis_Homo sapiens_hsa000611.10586186
44p53 signaling pathway_Homo sapiens_hsa041151.09223775
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08658319
46Salmonella infection_Homo sapiens_hsa051321.07864696
47Shigellosis_Homo sapiens_hsa051311.07116810
48Adherens junction_Homo sapiens_hsa045201.06208576
49Acute myeloid leukemia_Homo sapiens_hsa052211.05700768
50Hepatitis B_Homo sapiens_hsa051611.05662197
51Allograft rejection_Homo sapiens_hsa053301.05659282
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05496535
53Type I diabetes mellitus_Homo sapiens_hsa049401.04979339
54Chronic myeloid leukemia_Homo sapiens_hsa052201.04791015
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03374967
56Bladder cancer_Homo sapiens_hsa052191.01232091
57Amoebiasis_Homo sapiens_hsa051460.99409220
58Lysosome_Homo sapiens_hsa041420.99394175
59DNA replication_Homo sapiens_hsa030300.99057224
60Base excision repair_Homo sapiens_hsa034100.96839761
61* Galactose metabolism_Homo sapiens_hsa000520.92282970
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91231833
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89926409
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87908996
65Starch and sucrose metabolism_Homo sapiens_hsa005000.86717369
66Pancreatic cancer_Homo sapiens_hsa052120.85255010
67Focal adhesion_Homo sapiens_hsa045100.84927356
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84064669
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83616662
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83310563
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80338631
72Proteoglycans in cancer_Homo sapiens_hsa052050.78215156
73Platelet activation_Homo sapiens_hsa046110.78005612
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.77238002
75Hepatitis C_Homo sapiens_hsa051600.76074952
76Mineral absorption_Homo sapiens_hsa049780.75922201
77Prion diseases_Homo sapiens_hsa050200.75879627
78HTLV-I infection_Homo sapiens_hsa051660.75734451
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71280863
80Vibrio cholerae infection_Homo sapiens_hsa051100.70287628
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69569485
82Phagosome_Homo sapiens_hsa041450.69145921
83Renin-angiotensin system_Homo sapiens_hsa046140.68733009
84MicroRNAs in cancer_Homo sapiens_hsa052060.65018810
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64583399
86One carbon pool by folate_Homo sapiens_hsa006700.64389887
87Chemokine signaling pathway_Homo sapiens_hsa040620.64388647
88Glutathione metabolism_Homo sapiens_hsa004800.64337092
89Asthma_Homo sapiens_hsa053100.64044476
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63207900
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62549308
92Rheumatoid arthritis_Homo sapiens_hsa053230.62209753
93Chemical carcinogenesis_Homo sapiens_hsa052040.61176550
94Viral carcinogenesis_Homo sapiens_hsa052030.60929212
95Thyroid cancer_Homo sapiens_hsa052160.60919294
96Non-homologous end-joining_Homo sapiens_hsa034500.60398279
97Autoimmune thyroid disease_Homo sapiens_hsa053200.60147605
98Endocytosis_Homo sapiens_hsa041440.58274584
99Prolactin signaling pathway_Homo sapiens_hsa049170.57193138
100HIF-1 signaling pathway_Homo sapiens_hsa040660.56816596
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.55851978
102Renal cell carcinoma_Homo sapiens_hsa052110.53961693
103Notch signaling pathway_Homo sapiens_hsa043300.53621155
104Pentose phosphate pathway_Homo sapiens_hsa000300.53469258
105Arachidonic acid metabolism_Homo sapiens_hsa005900.53318723
106T cell receptor signaling pathway_Homo sapiens_hsa046600.53286792
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.52457119
108PPAR signaling pathway_Homo sapiens_hsa033200.52451578
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51644071
110Insulin resistance_Homo sapiens_hsa049310.51538358
111Vitamin digestion and absorption_Homo sapiens_hsa049770.51017626
112Prostate cancer_Homo sapiens_hsa052150.49949634
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48934353
114TGF-beta signaling pathway_Homo sapiens_hsa043500.48755211
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48703362
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48308435
117Melanoma_Homo sapiens_hsa052180.47556303
118Epstein-Barr virus infection_Homo sapiens_hsa051690.47533403
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47181568
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46139032
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43377624
122FoxO signaling pathway_Homo sapiens_hsa040680.41927510

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »