B4GALT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.11726722
2locomotory exploration behavior (GO:0035641)5.04893369
3vocalization behavior (GO:0071625)5.03765356
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98523084
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.97242327
6synaptic vesicle maturation (GO:0016188)4.90150986
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75598687
8neuron cell-cell adhesion (GO:0007158)4.64411032
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.62846144
10protein localization to synapse (GO:0035418)4.54488175
11dendritic spine morphogenesis (GO:0060997)4.53308224
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.36691587
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.29427013
14synaptic vesicle exocytosis (GO:0016079)4.26004838
15regulation of glutamate receptor signaling pathway (GO:1900449)4.22557003
16glutamate secretion (GO:0014047)4.22520170
17protein retention in ER lumen (GO:0006621)4.22092056
18neuron recognition (GO:0008038)4.13998303
19regulation of synaptic vesicle exocytosis (GO:2000300)4.13916663
20exploration behavior (GO:0035640)4.13247467
21axonal fasciculation (GO:0007413)4.05811668
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93824598
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.84932280
24cell migration in hindbrain (GO:0021535)3.83964062
25regulation of synapse structural plasticity (GO:0051823)3.82818861
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.79183954
27proline biosynthetic process (GO:0006561)3.73363968
28postsynaptic membrane organization (GO:0001941)3.72961130
29dendrite morphogenesis (GO:0048813)3.66871804
30regulation of neuronal synaptic plasticity (GO:0048168)3.65202593
31positive regulation of synapse maturation (GO:0090129)3.63089176
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.58698123
33regulation of synaptic vesicle transport (GO:1902803)3.57297424
34pyrimidine nucleobase catabolic process (GO:0006208)3.56693580
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.56085538
36regulation of dendritic spine morphogenesis (GO:0061001)3.39864205
37neurotransmitter secretion (GO:0007269)3.39207419
38synaptic transmission, glutamatergic (GO:0035249)3.36525780
39central nervous system projection neuron axonogenesis (GO:0021952)3.30168329
40adherens junction assembly (GO:0034333)3.29110661
41glutamate receptor signaling pathway (GO:0007215)3.28836398
42neurotransmitter-gated ion channel clustering (GO:0072578)3.27150446
43regulation of early endosome to late endosome transport (GO:2000641)3.26886434
44ribosomal small subunit biogenesis (GO:0042274)3.24890599
45proline transport (GO:0015824)3.22436035
46COPI coating of Golgi vesicle (GO:0048205)3.21039496
47Golgi transport vesicle coating (GO:0048200)3.21039496
48convergent extension (GO:0060026)3.15681592
49innervation (GO:0060384)3.15172461
50hemidesmosome assembly (GO:0031581)3.15136643
51cell-substrate adherens junction assembly (GO:0007045)3.14732667
52focal adhesion assembly (GO:0048041)3.14732667
53regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.14540866
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11891253
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.10459929
56auditory behavior (GO:0031223)3.10422113
57neuron-neuron synaptic transmission (GO:0007270)3.09437419
58regulation of translational fidelity (GO:0006450)3.09169948
59cochlea morphogenesis (GO:0090103)3.08548475
60cell-substrate junction assembly (GO:0007044)3.06103258
61positive regulation of membrane potential (GO:0045838)3.03699552
62dendritic spine organization (GO:0097061)3.03578032
63negative regulation of microtubule polymerization (GO:0031115)3.02962683
64neuronal action potential propagation (GO:0019227)3.02187774
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01776755
66establishment of nucleus localization (GO:0040023)3.01669200
67cytoskeletal anchoring at plasma membrane (GO:0007016)3.01141361
68cerebellar Purkinje cell layer development (GO:0021680)2.97439952
69neuromuscular process controlling balance (GO:0050885)2.95989189
70long-term memory (GO:0007616)2.93489119
71axon extension (GO:0048675)2.93415493
72regulation of postsynaptic membrane potential (GO:0060078)2.89839543
73regulation of establishment of planar polarity (GO:0090175)2.88548660
74activation of protein kinase A activity (GO:0034199)2.88459214
75positive regulation of synapse assembly (GO:0051965)2.88388857
76basement membrane organization (GO:0071711)2.88208090
77protein heterotrimerization (GO:0070208)2.86618357
78presynaptic membrane assembly (GO:0097105)2.86510006
79regulation of synaptic plasticity (GO:0048167)2.85201373
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.84443014
81regulation of dendritic spine development (GO:0060998)2.84295879
82positive regulation of dendritic spine morphogenesis (GO:0061003)2.83841999
83regulation of neurotransmitter secretion (GO:0046928)2.81745060
84synapse assembly (GO:0007416)2.81426818
85nucleobase catabolic process (GO:0046113)2.80243433
86positive regulation of dendritic spine development (GO:0060999)2.79594472
87synaptic vesicle endocytosis (GO:0048488)2.79485603
88peptidyl-arginine omega-N-methylation (GO:0035247)2.78298148
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.75351321
90positive regulation of neurotransmitter secretion (GO:0001956)2.74790242
91gamma-aminobutyric acid transport (GO:0015812)2.74744148
92regulation of synapse maturation (GO:0090128)2.74302141
93regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72970907
94retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72747066
95synapse organization (GO:0050808)2.71973490
96transmission of nerve impulse (GO:0019226)2.70857545
97positive regulation of synaptic transmission, GABAergic (GO:0032230)2.70388718
98semaphorin-plexin signaling pathway (GO:0071526)2.68205950
99central nervous system neuron axonogenesis (GO:0021955)2.67825463
100clathrin coat assembly (GO:0048268)2.67104024
101social behavior (GO:0035176)2.66781434
102intraspecies interaction between organisms (GO:0051703)2.66781434
103regulation of synapse organization (GO:0050807)2.66027265
104skin morphogenesis (GO:0043589)2.65983880
105paraxial mesoderm development (GO:0048339)2.65443305
106regulation of vesicle fusion (GO:0031338)2.65099609
107heterochromatin organization (GO:0070828)2.64935965
108cerebellum development (GO:0021549)2.64921977
109protein maturation by protein folding (GO:0022417)2.64737926
110hippocampus development (GO:0021766)2.64074844
111neuron projection extension (GO:1990138)2.63891647
112proline metabolic process (GO:0006560)2.63570879
113regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63221253
114cerebral cortex radially oriented cell migration (GO:0021799)2.62781186
115positive regulation of neurotransmitter transport (GO:0051590)2.62410824
116response to auditory stimulus (GO:0010996)2.62359498
117neurotransmitter transport (GO:0006836)2.62165518
118regulation of synaptic transmission, glutamatergic (GO:0051966)2.61416065
119neuronal ion channel clustering (GO:0045161)2.61415294
120prepulse inhibition (GO:0060134)2.60803825
121dopamine receptor signaling pathway (GO:0007212)2.60727352
122behavioral fear response (GO:0001662)2.60596647
123behavioral defense response (GO:0002209)2.60596647
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59439553
125ephrin receptor signaling pathway (GO:0048013)2.58932303
126regulation of neurotransmitter transport (GO:0051588)2.58357218
127learning (GO:0007612)2.58221386
128presynaptic membrane organization (GO:0097090)2.57802489
129regulation of synapse assembly (GO:0051963)2.56328531
130histone arginine methylation (GO:0034969)2.54839202
131regulation of dendrite morphogenesis (GO:0048814)2.53676105
132protein complex localization (GO:0031503)2.53398445
133long-term synaptic potentiation (GO:0060291)2.52035543
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51836437
135negative regulation of catenin import into nucleus (GO:0035414)2.50795250
136negative regulation of cell size (GO:0045792)2.50524351
137DNA unwinding involved in DNA replication (GO:0006268)2.47545827
138protein localization to endosome (GO:0036010)2.47399527
139apoptotic process involved in morphogenesis (GO:0060561)2.47299699
140collagen fibril organization (GO:0030199)2.46122519
141establishment of apical/basal cell polarity (GO:0035089)2.46063657
142non-canonical Wnt signaling pathway (GO:0035567)2.45713617
143mitotic chromosome condensation (GO:0007076)2.45626055
144bone trabecula formation (GO:0060346)2.44920459
145axon extension involved in axon guidance (GO:0048846)2.43487547
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.43487547
147epithelial cell-cell adhesion (GO:0090136)2.43084068
148endodermal cell differentiation (GO:0035987)2.42348707
149endothelial cell morphogenesis (GO:0001886)2.40719714
150positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.40310002
151cellular protein complex localization (GO:0034629)2.38906787
152nucleobase-containing small molecule interconversion (GO:0015949)2.37235435
153neural tube development (GO:0021915)2.35829583
154peptidyl-proline hydroxylation (GO:0019511)2.35572731
155viral transcription (GO:0019083)2.34685339
156activation of Rac GTPase activity (GO:0032863)2.34284654
157kidney mesenchyme development (GO:0072074)2.32192896
158protein targeting to plasma membrane (GO:0072661)2.31959536
159negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.28981445
160negative regulation of chondrocyte differentiation (GO:0032331)2.27802390
161camera-type eye morphogenesis (GO:0048593)2.27745123
162G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.27177212
163embryonic skeletal joint morphogenesis (GO:0060272)2.25646737
164notochord development (GO:0030903)2.25123642
165peptidyl-arginine methylation (GO:0018216)2.23814451
166peptidyl-arginine N-methylation (GO:0035246)2.23814451
167desmosome organization (GO:0002934)2.23656911
168maternal placenta development (GO:0001893)2.23082544
169negative regulation of fatty acid transport (GO:2000192)2.22706383
170cell-cell junction maintenance (GO:0045217)2.21706028
1714-hydroxyproline metabolic process (GO:0019471)2.20571730
172dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.20335047
173L-serine metabolic process (GO:0006563)2.17305952
174translational termination (GO:0006415)2.15586882
175vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.15153541
176eye morphogenesis (GO:0048592)2.14760106
177maturation of SSU-rRNA (GO:0030490)2.11938317
178tooth mineralization (GO:0034505)2.09914087
179chondrocyte proliferation (GO:0035988)2.08824721
180atrioventricular valve morphogenesis (GO:0003181)2.08434498
181mesoderm formation (GO:0001707)2.07215243
182outer ear morphogenesis (GO:0042473)2.07048391
183stress fiber assembly (GO:0043149)2.06392733
184adenine nucleotide transport (GO:0051503)2.06142098
185establishment or maintenance of bipolar cell polarity (GO:0061245)2.06072544
186establishment or maintenance of apical/basal cell polarity (GO:0035088)2.06072544
187hippo signaling (GO:0035329)2.04618671
188regulation of glucose import in response to insulin stimulus (GO:2001273)2.04288886
189establishment or maintenance of monopolar cell polarity (GO:0061339)2.03823018
190establishment of monopolar cell polarity (GO:0061162)2.03823018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84923131
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.61897648
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.22426970
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.03851554
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98653769
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97096393
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91661992
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91661992
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.88501778
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80902306
11GBX2_23144817_ChIP-Seq_PC3_Human2.80555521
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58997414
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.58332737
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56651733
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54463781
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48938431
17* LXR_22292898_ChIP-Seq_THP-1_Human2.47232383
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.44183320
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.43190237
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39781139
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36317223
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36254559
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35603208
24REST_21632747_ChIP-Seq_MESCs_Mouse2.30539698
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.25589691
26ZNF263_19887448_ChIP-Seq_K562_Human2.25454355
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13982336
28E2F7_22180533_ChIP-Seq_HELA_Human2.12302040
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11551621
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09691323
31* RACK7_27058665_Chip-Seq_MCF-7_Human2.09431569
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09322090
33DROSHA_22980978_ChIP-Seq_HELA_Human2.05748196
34ELK3_25401928_ChIP-Seq_HUVEC_Human2.04880551
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03072255
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00657662
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99301243
38* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98106068
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.91428452
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.90189364
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.89399145
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87432077
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82174823
44* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.80279024
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.77401772
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.73914837
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.73010401
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72359114
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70568585
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.69430904
51ZNF274_21170338_ChIP-Seq_K562_Hela1.68219697
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.68151601
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67558272
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67546790
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66988845
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66505232
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66048841
58AR_21572438_ChIP-Seq_LNCaP_Human1.64207011
59* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63112769
60* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59915416
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59781232
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.59363992
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58150553
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57557093
65XRN2_22483619_ChIP-Seq_HELA_Human1.55438659
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53678191
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53622322
68MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52550484
69* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50946098
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.50773792
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48306367
72CLOCK_20551151_ChIP-Seq_293T_Human1.44455380
73* VDR_21846776_ChIP-Seq_THP-1_Human1.43894444
74P68_20966046_ChIP-Seq_HELA_Human1.42444850
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40982685
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.40399997
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39956955
78TP53_22127205_ChIP-Seq_IMR90_Human1.39868811
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38977107
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36943215
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35986213
82MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35121115
83CREB1_26743006_Chip-Seq_LNCaP_Human1.34377576
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34227630
85KDM2B_26808549_Chip-Seq_DND41_Human1.33806004
86* KDM2B_26808549_Chip-Seq_K562_Human1.32846501
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32839709
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.31014884
89* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31009622
90* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30827286
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30618322
92ESR2_21235772_ChIP-Seq_MCF-7_Human1.29680044
93RNF2_27304074_Chip-Seq_NSC_Mouse1.29439135
94SMC4_20622854_ChIP-Seq_HELA_Human1.27888966
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27829813
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27599175
97ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27537666
98ATF3_27146783_Chip-Seq_COLON_Human1.27522871
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26465469
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26311158
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26221000
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25977662
103* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25524873
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23503958
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23215297
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22073025
107MYC_22102868_ChIP-Seq_BL_Human1.21797627
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21490296
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.20795618
110* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20024181
111* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20018133
112SMAD4_21799915_ChIP-Seq_A2780_Human1.20017834
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.17700720
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.17326466
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17042774
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16033326
117* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15742791
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.14967502
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14823181
120* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14563880
121MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13911555
122AR_19668381_ChIP-Seq_PC3_Human1.12999727
123OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12780676
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12627309
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12192761
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11524452
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.10347766
128MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09848437
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09378375
130KDM2B_26808549_Chip-Seq_JURKAT_Human1.09350750
131AR_21909140_ChIP-Seq_LNCAP_Human1.07350466
132HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06996413
133TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04888911
134* UBF1/2_26484160_Chip-Seq_HMECs_Human1.04277611
135YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04267490
136* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03876247
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03564312
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03322170
139TAF15_26573619_Chip-Seq_HEK293_Human1.03062543
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02700782
141NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02082622
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02076195
143OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01521279
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00189545
145ISL1_27105846_Chip-Seq_CPCs_Mouse1.00142807
146P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99329844
147SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97764597
148IGF1R_20145208_ChIP-Seq_DFB_Human0.94835911
149P300_19829295_ChIP-Seq_ESCs_Human0.94581873
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.94266305
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94235357
152ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93707758
153TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92561763
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92561763
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91987874
156* CTCF_27219007_Chip-Seq_Bcells_Human0.91436097
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90455498
158TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90354193
159FUS_26573619_Chip-Seq_HEK293_Human0.90264070
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89934608
161AR_25329375_ChIP-Seq_VCAP_Human0.88958853
162STAT3_23295773_ChIP-Seq_U87_Human0.86711649
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85729393
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.85500890
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.85412683
166ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85236643
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.84851197
168CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84487501
169JUN_21703547_ChIP-Seq_K562_Human0.84094851
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.83574366
171TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80769061
172EP300_21415370_ChIP-Seq_HL-1_Mouse0.80636185
173NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79699625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25740215
2MP0003705_abnormal_hypodermis_morpholog4.74816958
3MP0008438_abnormal_cutaneous_collagen4.40766696
4MP0003880_abnormal_central_pattern3.53273119
5MP0003635_abnormal_synaptic_transmissio3.30931642
6MP0004270_analgesia3.15583660
7* MP0002063_abnormal_learning/memory/cond2.72556172
8MP0005257_abnormal_intraocular_pressure2.67470736
9MP0004272_abnormal_basement_membrane2.51716780
10MP0000778_abnormal_nervous_system2.49578354
11MP0009745_abnormal_behavioral_response2.43054382
12MP0005423_abnormal_somatic_nervous2.33856613
13MP0001968_abnormal_touch/_nociception2.28493441
14MP0002734_abnormal_mechanical_nocicepti2.25329438
15MP0002064_seizures2.19274655
16MP0002572_abnormal_emotion/affect_behav2.14031697
17MP0003122_maternal_imprinting2.13271460
18MP0000566_synostosis1.95570187
19MP0009379_abnormal_foot_pigmentation1.90824189
20MP0002184_abnormal_innervation1.89815185
21MP0009046_muscle_twitch1.89387898
22MP0001486_abnormal_startle_reflex1.88066733
23MP0009780_abnormal_chondrocyte_physiolo1.87717183
24MP0005275_abnormal_skin_tensile1.84235040
25MP0004858_abnormal_nervous_system1.83043945
26MP0003566_abnormal_cell_adhesion1.80111713
27MP0002736_abnormal_nociception_after1.71638628
28MP0002272_abnormal_nervous_system1.67864397
29MP0005623_abnormal_meninges_morphology1.67390667
30MP0004811_abnormal_neuron_physiology1.64965502
31MP0001849_ear_inflammation1.64952272
32MP0002733_abnormal_thermal_nociception1.63037702
33MP0001958_emphysema1.61064270
34MP0000955_abnormal_spinal_cord1.60654852
35MP0002557_abnormal_social/conspecific_i1.58128372
36MP0001440_abnormal_grooming_behavior1.56263588
37MP0000762_abnormal_tongue_morphology1.56161190
38MP0003385_abnormal_body_wall1.53954888
39MP0000003_abnormal_adipose_tissue1.53523048
40MP0003279_aneurysm1.52817198
41MP0000579_abnormal_nail_morphology1.51381707
42MP0002653_abnormal_ependyma_morphology1.50896092
43MP0009384_cardiac_valve_regurgitation1.49957855
44MP0001970_abnormal_pain_threshold1.48146848
45MP0002822_catalepsy1.47714831
46MP0006276_abnormal_autonomic_nervous1.45995452
47MP0002877_abnormal_melanocyte_morpholog1.45550037
48MP0002735_abnormal_chemical_nociception1.44859747
49* MP0002882_abnormal_neuron_morphology1.43896431
50MP0002060_abnormal_skin_morphology1.43302800
51MP0002067_abnormal_sensory_capabilities1.41498758
52MP0005409_darkened_coat_color1.39769952
53MP0010030_abnormal_orbit_morphology1.38338658
54MP0000733_abnormal_muscle_development1.38211601
55MP0000678_abnormal_parathyroid_gland1.37454972
56* MP0002152_abnormal_brain_morphology1.35633329
57MP0003787_abnormal_imprinting1.34140335
58MP0001348_abnormal_lacrimal_gland1.33908453
59MP0004185_abnormal_adipocyte_glucose1.33651717
60MP0002089_abnormal_postnatal_growth/wei1.32629276
61MP0000751_myopathy1.31664524
62MP0003283_abnormal_digestive_organ1.30119305
63MP0000631_abnormal_neuroendocrine_gland1.27479039
64MP0003329_amyloid_beta_deposits1.27130673
65MP0004924_abnormal_behavior1.26223930
66MP0005386_behavior/neurological_phenoty1.26223930
67MP0005076_abnormal_cell_differentiation1.25783149
68MP0002697_abnormal_eye_size1.24748374
69* MP0003861_abnormal_nervous_system1.24321226
70MP0003942_abnormal_urinary_system1.23395319
71MP0003123_paternal_imprinting1.22733900
72MP0000537_abnormal_urethra_morphology1.22656875
73MP0005508_abnormal_skeleton_morphology1.22017620
74MP0000013_abnormal_adipose_tissue1.20762662
75MP0000569_abnormal_digit_pigmentation1.19572498
76MP0003121_genomic_imprinting1.19524525
77MP0000759_abnormal_skeletal_muscle1.18219916
78MP0008569_lethality_at_weaning1.17418930
79MP0003941_abnormal_skin_development1.16993419
80MP0003119_abnormal_digestive_system1.16796362
81* MP0002066_abnormal_motor_capabilities/c1.16548334
82MP0000534_abnormal_ureter_morphology1.16548093
83MP0005499_abnormal_olfactory_system1.15663618
84MP0005394_taste/olfaction_phenotype1.15663618
85MP0009250_abnormal_appendicular_skeleto1.13882363
86MP0000750_abnormal_muscle_regeneration1.13056167
87MP0001529_abnormal_vocalization1.12596674
88MP0002909_abnormal_adrenal_gland1.11089891
89MP0004233_abnormal_muscle_weight1.10691801
90MP0002234_abnormal_pharynx_morphology1.10431782
91MP0000049_abnormal_middle_ear1.09866037
92MP0001346_abnormal_lacrimal_gland1.09854218
93MP0004885_abnormal_endolymph1.09599689
94MP0005501_abnormal_skin_physiology1.07061232
95MP0001299_abnormal_eye_distance/1.06364411
96MP0001501_abnormal_sleep_pattern1.05806277
97MP0008932_abnormal_embryonic_tissue1.05524270
98MP0003938_abnormal_ear_development1.05343501
99MP0010368_abnormal_lymphatic_system1.05270978
100MP0000747_muscle_weakness1.04401908
101MP0010234_abnormal_vibrissa_follicle1.02388021
102MP0000467_abnormal_esophagus_morphology1.01396201
103MP0001188_hyperpigmentation1.00867446
104MP0002108_abnormal_muscle_morphology1.00372956
105MP0003879_abnormal_hair_cell1.00081773
106MP0001984_abnormal_olfaction1.00063147
107MP0004145_abnormal_muscle_electrophysio0.98343275
108MP0003755_abnormal_palate_morphology0.97529345
109MP0002752_abnormal_somatic_nervous0.97307118
110MP0003111_abnormal_nucleus_morphology0.96704368
111MP0004087_abnormal_muscle_fiber0.96677594
112MP0005187_abnormal_penis_morphology0.96478772
113MP0009672_abnormal_birth_weight0.96136629
114MP0005375_adipose_tissue_phenotype0.95670680
115MP0005171_absent_coat_pigmentation0.95516843
116MP0008789_abnormal_olfactory_epithelium0.95441276
117MP0001905_abnormal_dopamine_level0.95048029
118MP0005503_abnormal_tendon_morphology0.94938926
119MP0000462_abnormal_digestive_system0.94493281
120MP0001661_extended_life_span0.94309109
121MP0003937_abnormal_limbs/digits/tail_de0.91996636
122MP0005451_abnormal_body_composition0.91114097
123MP0002896_abnormal_bone_mineralization0.90784142
124MP0002114_abnormal_axial_skeleton0.90097229
125MP0002796_impaired_skin_barrier0.89475351
126MP0002092_abnormal_eye_morphology0.89269787
127MP0002085_abnormal_embryonic_tissue0.88707319
128MP0002116_abnormal_craniofacial_bone0.88261148
129MP0002249_abnormal_larynx_morphology0.88118221
130MP0002102_abnormal_ear_morphology0.88003064
131MP0005646_abnormal_pituitary_gland0.87939172
132MP0001177_atelectasis0.87228053
133MP0000767_abnormal_smooth_muscle0.86723917
134MP0001730_embryonic_growth_arrest0.85897036
135MP0006072_abnormal_retinal_apoptosis0.85672449
136MP0003091_abnormal_cell_migration0.85468229
137MP0002751_abnormal_autonomic_nervous0.85102592
138MP0004742_abnormal_vestibular_system0.85073857
139MP0000749_muscle_degeneration0.84414647
140MP0005023_abnormal_wound_healing0.83470652
141MP0002081_perinatal_lethality0.83250818
142MP0005551_abnormal_eye_electrophysiolog0.81050202
143MP0010352_gastrointestinal_tract_polyps0.80519754
144MP0003453_abnormal_keratinocyte_physiol0.79025940
145MP0003115_abnormal_respiratory_system0.78406810
146MP0002282_abnormal_trachea_morphology0.78152090
147MP0003137_abnormal_impulse_conducting0.77677942
148MP0002111_abnormal_tail_morphology0.76362281
149MP0002233_abnormal_nose_morphology0.76323743
150MP0005248_abnormal_Harderian_gland0.76263934
151MP0004957_abnormal_blastocyst_morpholog0.76031874
152MP0004085_abnormal_heartbeat0.75500526
153MP0003634_abnormal_glial_cell0.75476180
154MP0005666_abnormal_adipose_tissue0.74229681
155MP0001502_abnormal_circadian_rhythm0.73533508
156MP0003315_abnormal_perineum_morphology0.73517244
157MP0000350_abnormal_cell_proliferation0.73050072
158MP0002932_abnormal_joint_morphology0.72877666
159MP0001943_abnormal_respiration0.72423085
160MP0005197_abnormal_uvea_morphology0.72304079
161MP0000432_abnormal_head_morphology0.72279131
162MP0000026_abnormal_inner_ear0.72212792
163MP0002084_abnormal_developmental_patter0.72088623
164MP0002069_abnormal_eating/drinking_beha0.72065129
165MP0009053_abnormal_anal_canal0.70991562
166MP0000428_abnormal_craniofacial_morphol0.70804039
167MP0002080_prenatal_lethality0.70499475
168MP0003935_abnormal_craniofacial_develop0.70276743

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.11555220
2Myokymia (HP:0002411)4.68282262
3Focal motor seizures (HP:0011153)4.35037239
4Focal seizures (HP:0007359)3.77538660
5Visual hallucinations (HP:0002367)3.56579361
6Ulnar bowing (HP:0003031)3.30418065
7Epileptic encephalopathy (HP:0200134)3.16590575
8Fragile skin (HP:0001030)3.04200929
9Spinal rigidity (HP:0003306)2.97995743
10Ankle contracture (HP:0006466)2.93631579
11Atrophic scars (HP:0001075)2.90712539
12Type 1 muscle fiber predominance (HP:0003803)2.83041789
13Turricephaly (HP:0000262)2.74909589
14Achilles tendon contracture (HP:0001771)2.71232027
15Atonic seizures (HP:0010819)2.66201511
16Broad-based gait (HP:0002136)2.59213243
17Megalencephaly (HP:0001355)2.57536675
18Vertebral compression fractures (HP:0002953)2.52944047
19Progressive cerebellar ataxia (HP:0002073)2.52080573
20Ankle clonus (HP:0011448)2.49830510
21Mutism (HP:0002300)2.48588533
22Coronal craniosynostosis (HP:0004440)2.46413475
23Mildly elevated creatine phosphokinase (HP:0008180)2.45893873
24Amblyopia (HP:0000646)2.45152287
25Soft skin (HP:0000977)2.43132789
26Mitral regurgitation (HP:0001653)2.41626841
27Shallow orbits (HP:0000586)2.41588439
28Renal duplication (HP:0000075)2.41399671
29Absence seizures (HP:0002121)2.40274175
30Abnormality of the Achilles tendon (HP:0005109)2.38486996
31Supranuclear gaze palsy (HP:0000605)2.36611255
32Bronchomalacia (HP:0002780)2.36277542
33Disproportionate tall stature (HP:0001519)2.34837351
34Biconcave vertebral bodies (HP:0004586)2.32901883
35Amyotrophic lateral sclerosis (HP:0007354)2.32464873
36Increased variability in muscle fiber diameter (HP:0003557)2.31519218
37Abnormality of the lower motor neuron (HP:0002366)2.27479188
38Papilledema (HP:0001085)2.26660920
39Distal upper limb amyotrophy (HP:0007149)2.26469661
40Upper limb amyotrophy (HP:0009129)2.26469661
41Insomnia (HP:0100785)2.26331474
42Wormian bones (HP:0002645)2.25971228
43Blue sclerae (HP:0000592)2.25611917
44Pointed chin (HP:0000307)2.25186450
45Vascular tortuosity (HP:0004948)2.24263909
46Poor eye contact (HP:0000817)2.23474463
47Broad metatarsal (HP:0001783)2.23360232
48Hypoventilation (HP:0002791)2.22308113
49Neonatal short-limb short stature (HP:0008921)2.21398748
50Obstructive sleep apnea (HP:0002870)2.19532810
51Increased connective tissue (HP:0009025)2.18102144
52Generalized tonic-clonic seizures (HP:0002069)2.15966399
53Bladder diverticulum (HP:0000015)2.14899771
54Cerebral inclusion bodies (HP:0100314)2.14439999
55Limb dystonia (HP:0002451)2.13972173
56Elbow flexion contracture (HP:0002987)2.13547906
57Premature skin wrinkling (HP:0100678)2.12054267
58Drooling (HP:0002307)2.12050264
59Excessive salivation (HP:0003781)2.12050264
60Pterygium (HP:0001059)2.11036645
61Cerebral aneurysm (HP:0004944)2.10954086
62Impaired vibration sensation in the lower limbs (HP:0002166)2.10169868
63Overgrowth (HP:0001548)2.09780788
64Genetic anticipation (HP:0003743)2.09031536
65Insidious onset (HP:0003587)2.08831422
66Termporal pattern (HP:0011008)2.08831422
67Febrile seizures (HP:0002373)2.08488635
68Protrusio acetabuli (HP:0003179)2.08184800
69Dialeptic seizures (HP:0011146)2.05931253
70Bowing of the arm (HP:0006488)2.05814038
71Bowed forearm bones (HP:0003956)2.05814038
72Arterial tortuosity (HP:0005116)2.05175347
73Buphthalmos (HP:0000557)2.05149798
74Distal lower limb amyotrophy (HP:0008944)2.04469998
75Cervical subluxation (HP:0003308)2.03804091
76Torticollis (HP:0000473)2.03779637
77Hyperextensible skin (HP:0000974)2.03775715
78Aortic dissection (HP:0002647)2.02944631
79Depression (HP:0000716)2.01823860
80Thin ribs (HP:0000883)2.00013218
81Action tremor (HP:0002345)1.99751673
82Hepatoblastoma (HP:0002884)1.98398665
83Short nail (HP:0001799)1.98147223
84Abnormality of skeletal muscle fiber size (HP:0012084)1.96883704
85Urinary bladder sphincter dysfunction (HP:0002839)1.96825462
86Deviation of the hallux (HP:0010051)1.92491318
87Abnormal social behavior (HP:0012433)1.92434077
88Impaired social interactions (HP:0000735)1.92434077
89Round ear (HP:0100830)1.91410266
90Hemiparesis (HP:0001269)1.90578313
91Myopathic facies (HP:0002058)1.90501563
92Abnormality of the calcaneus (HP:0008364)1.90379211
93Partial duplication of the phalanx of hand (HP:0009999)1.90008391
94Generalized amyotrophy (HP:0003700)1.89671599
95Absent speech (HP:0001344)1.89012892
96Aortic aneurysm (HP:0004942)1.88662425
97Calcaneovalgus deformity (HP:0001848)1.88279460
98Mitral valve prolapse (HP:0001634)1.88061567
99Hallux valgus (HP:0001822)1.87166221
100Patellar dislocation (HP:0002999)1.87030360
101Arnold-Chiari malformation (HP:0002308)1.86506620
102Sacral dimple (HP:0000960)1.86017404
103Abnormal eating behavior (HP:0100738)1.85633461
104Hyperacusis (HP:0010780)1.84970472
105Hyperthyroidism (HP:0000836)1.84512619
106Hypoplasia of the brainstem (HP:0002365)1.84482709
107Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84482709
108Shoulder girdle muscle weakness (HP:0003547)1.84094815
109Neurofibrillary tangles (HP:0002185)1.84020659
110Overriding aorta (HP:0002623)1.83717425
111Abnormality of dentin (HP:0010299)1.83704365
112Abnormality of the corticospinal tract (HP:0002492)1.83300706
113Trismus (HP:0000211)1.83282580
114Long palpebral fissure (HP:0000637)1.81967091
115Urinary urgency (HP:0000012)1.81261955
116Spinal cord compression (HP:0002176)1.81048391
117Asymmetry of the thorax (HP:0001555)1.80761099
118Partial duplication of thumb phalanx (HP:0009944)1.80368935
119Agitation (HP:0000713)1.80270243
120Stereotypic behavior (HP:0000733)1.79986815
121Deformed tarsal bones (HP:0008119)1.79658550
122Back pain (HP:0003418)1.77338881
123Slender build (HP:0001533)1.77010204
124Anxiety (HP:0000739)1.76855179
125Joint laxity (HP:0001388)1.76102425
126Stridor (HP:0010307)1.76052283
127Focal dystonia (HP:0004373)1.75662402
128Thin bony cortex (HP:0002753)1.75410407
129Epileptiform EEG discharges (HP:0011182)1.75176489
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74471526
131Short 4th metacarpal (HP:0010044)1.74471526
132EEG with generalized epileptiform discharges (HP:0011198)1.73883079
133Breech presentation (HP:0001623)1.73668318
134Bowel diverticulosis (HP:0005222)1.73498669
135Polyphagia (HP:0002591)1.73473643
136Gait imbalance (HP:0002141)1.72977380
137Abnormality of the acetabulum (HP:0003170)1.72927436
138Lower limb amyotrophy (HP:0007210)1.72716606
139Broad distal phalanx of finger (HP:0009836)1.72012346
140Dysdiadochokinesis (HP:0002075)1.71983108
141Hand muscle atrophy (HP:0009130)1.71389527
142Hypsarrhythmia (HP:0002521)1.70196634
143Elfin facies (HP:0004428)1.70002527
144Truncal ataxia (HP:0002078)1.69515473
145Renovascular hypertension (HP:0100817)1.69286274
146Narrow nasal bridge (HP:0000446)1.68412105
147Ankyloglossia (HP:0010296)1.68391813
148Morphological abnormality of the middle ear (HP:0008609)1.68360665
149Genu recurvatum (HP:0002816)1.67675221
150Slender long bone (HP:0003100)1.66211114
151Flat cornea (HP:0007720)1.64857085
152Truncus arteriosus (HP:0001660)1.64735514
153Selective tooth agenesis (HP:0001592)1.64435970
154Adducted thumb (HP:0001181)1.64154051
155Follicular hyperkeratosis (HP:0007502)1.64153866
156Atelectasis (HP:0100750)1.63878256
157Generalized hypotonia (HP:0001290)1.63233854
158Aplasia involving bones of the extremities (HP:0009825)1.62834373
159Aplasia involving bones of the upper limbs (HP:0009823)1.62834373
160Aplasia of the phalanges of the hand (HP:0009802)1.62834373
161Natal tooth (HP:0000695)1.62715704
162Abnormality of the phalanges of the hallux (HP:0010057)1.62626078
163Spastic gait (HP:0002064)1.62474247
164Difficulty climbing stairs (HP:0003551)1.62187654
165Protruding ear (HP:0000411)1.61807946
166Abnormal delivery (HP:0001787)1.61775145
167Apathy (HP:0000741)1.61708699
168Lower limb muscle weakness (HP:0007340)1.61546742
169Lissencephaly (HP:0001339)1.61480145
170Sleep apnea (HP:0010535)1.60749408
171Abnormality of the labia minora (HP:0012880)1.60105072
172Hyperventilation (HP:0002883)1.59950150
173Sporadic (HP:0003745)1.59844676
174Specific learning disability (HP:0001328)1.58940706
175Craniofacial dystonia (HP:0012179)1.58925817
176Abnormality of the tricuspid valve (HP:0001702)1.58919545
177Congenital glaucoma (HP:0001087)1.55330570
178Fetal akinesia sequence (HP:0001989)1.53789990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.58494626
2EPHA43.40376587
3MAP3K93.22512306
4PRKD33.11972920
5NTRK33.03273585
6EEF2K2.76327937
7LATS22.68781419
8SMG12.64914767
9MAP3K42.56526995
10MINK12.50531183
11SIK12.43942488
12PAK62.35281807
13NME22.34016572
14NTRK22.30849189
15IRAK32.27503912
16TTN2.23497666
17DAPK22.12831843
18CASK2.12705903
19KSR12.12637503
20EPHA21.99622166
21MAPK131.90692951
22MAP2K71.80492201
23TYRO31.70298003
24KSR21.69522906
25NTRK11.61299123
26SIK21.57142999
27PLK21.52433927
28PNCK1.51608778
29EPHB21.45967782
30CAMKK11.40793320
31UHMK11.40722576
32DDR21.40040433
33CDK51.37311004
34MAP2K41.36375868
35PHKG21.34774097
36PHKG11.34774097
37DYRK21.31085478
38PAK41.28026311
39CDK121.27353092
40MAP3K101.27064415
41MST1R1.23254442
42MTOR1.20087607
43BUB11.15636588
44CDK181.15504520
45MET1.15211002
46CDK151.13305594
47PRPF4B1.13012051
48CDK141.11124285
49PAK31.11094525
50TAOK11.09354004
51LMTK21.08110924
52PAK21.07968505
53PDGFRA1.05539928
54DAPK11.02094700
55CDK11A1.01385057
56ICK1.00156571
57PRKCG0.99504621
58CDK80.98652753
59LIMK10.98587188
60TRIB30.96836514
61IRAK20.93069719
62STK380.92791065
63CSNK1G20.90325318
64PIM20.89612409
65AURKA0.89306006
66BRSK10.88979067
67MAP3K120.87796763
68MAP3K110.86276440
69CDK190.85454097
70GRK50.84478590
71MARK20.82011343
72RET0.81572241
73PTK2B0.79442746
74NEK10.79233670
75ERN10.78956156
76FGFR40.78879436
77TAOK20.78289112
78DYRK1A0.78016098
79STK110.76396065
80MAP3K20.75264410
81CDK70.73751112
82CAMK2A0.73479778
83MAP3K80.72939901
84MOS0.71825323
85DAPK30.71447365
86ABL20.70904617
87CHEK20.70471215
88AKT20.70276172
89TTK0.69148482
90CAMK1D0.67159018
91ERBB30.67071939
92PRKCZ0.65589508
93ALK0.64951115
94PDPK10.64700166
95PRKCH0.64380336
96LRRK20.63863364
97BCR0.61385347
98MAP3K60.60311208
99CDC42BPA0.60175092
100NEK20.57612540
101PTK60.57123202
102TNIK0.56969954
103CSNK1G30.56486497
104PAK10.55328654
105PRKD20.54580778
106ROCK20.54518038
107FER0.53976774
108ARAF0.53899438
109DMPK0.53696839
110FGFR20.53008995
111ROCK10.52683775
112FES0.52588492
113MYLK0.52543271
114RPS6KB20.52225857
115CAMK1G0.50958360
116RPS6KA20.50322484
117MAP2K10.49648457
118CAMK2G0.49498388
119SGK2230.49231284
120SGK4940.49231284
121PRKCI0.48702566
122SCYL20.48593523
123PRKG20.47715123
124ILK0.47049162
125RPS6KL10.46754421
126RPS6KC10.46754421
127TESK10.45998219
128CAMK10.45464957
129CSNK1A1L0.44525326
130LATS10.44481860
131CDC70.43909973
132CAMK2B0.43789094
133PKN20.42822302
134RAF10.42233947
135AURKB0.41653295
136TLK10.41399498
137MUSK0.41117169
138STK160.40695111
139PKN10.40405680
140MAPK100.39644879
141MAP2K20.39284393
142RIPK10.38821723
143FYN0.38718375
144RPS6KA30.38671738
145SGK10.38384060
146ERBB40.36952788
147PRKCE0.36942309
148ERBB20.36313101
149CSNK1E0.36188128
150BMX0.35595400
151BRAF0.35177708
152VRK20.34922257
153FGR0.34842831
154PTK20.34769162

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.93934678
2Synaptic vesicle cycle_Homo sapiens_hsa047212.71699677
3Sulfur relay system_Homo sapiens_hsa041222.38793603
4Circadian entrainment_Homo sapiens_hsa047132.37051580
5Olfactory transduction_Homo sapiens_hsa047402.35264576
6Long-term potentiation_Homo sapiens_hsa047202.34238206
7Glutamatergic synapse_Homo sapiens_hsa047242.25691815
8GABAergic synapse_Homo sapiens_hsa047272.25506047
9Vitamin B6 metabolism_Homo sapiens_hsa007502.24885132
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21247848
11Dopaminergic synapse_Homo sapiens_hsa047282.13991839
12Amphetamine addiction_Homo sapiens_hsa050312.13330583
13Morphine addiction_Homo sapiens_hsa050322.07154347
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03675453
15Axon guidance_Homo sapiens_hsa043601.95706037
16ECM-receptor interaction_Homo sapiens_hsa045121.89604218
17Cholinergic synapse_Homo sapiens_hsa047251.87883991
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85957456
19Biosynthesis of amino acids_Homo sapiens_hsa012301.81344868
20Cocaine addiction_Homo sapiens_hsa050301.73839068
21Long-term depression_Homo sapiens_hsa047301.72913290
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72124033
23Gap junction_Homo sapiens_hsa045401.70432578
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68310648
25Insulin secretion_Homo sapiens_hsa049111.66561113
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63756812
27Salivary secretion_Homo sapiens_hsa049701.62891122
28Oxytocin signaling pathway_Homo sapiens_hsa049211.60648320
29GnRH signaling pathway_Homo sapiens_hsa049121.58190488
30Glioma_Homo sapiens_hsa052141.55485618
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55055133
32Ribosome_Homo sapiens_hsa030101.53832763
33Renin secretion_Homo sapiens_hsa049241.51188268
34Gastric acid secretion_Homo sapiens_hsa049711.51079665
35Serotonergic synapse_Homo sapiens_hsa047261.50917417
36Melanogenesis_Homo sapiens_hsa049161.48245471
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38794418
38Phototransduction_Homo sapiens_hsa047441.38417851
39Estrogen signaling pathway_Homo sapiens_hsa049151.37299215
40ErbB signaling pathway_Homo sapiens_hsa040121.31367031
41Taste transduction_Homo sapiens_hsa047421.30832173
42Oocyte meiosis_Homo sapiens_hsa041141.29998685
43Notch signaling pathway_Homo sapiens_hsa043301.28918450
44DNA replication_Homo sapiens_hsa030301.27829655
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.21487607
46Calcium signaling pathway_Homo sapiens_hsa040201.21172742
47Pentose phosphate pathway_Homo sapiens_hsa000301.18430941
48Fructose and mannose metabolism_Homo sapiens_hsa000511.16063807
49Hedgehog signaling pathway_Homo sapiens_hsa043401.15912650
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12153256
51Wnt signaling pathway_Homo sapiens_hsa043101.11210182
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10332892
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09345860
54cAMP signaling pathway_Homo sapiens_hsa040241.09090502
55Endometrial cancer_Homo sapiens_hsa052131.07496455
56Hippo signaling pathway_Homo sapiens_hsa043901.06381777
57Thyroid cancer_Homo sapiens_hsa052161.05865866
58Cardiac muscle contraction_Homo sapiens_hsa042601.05802691
59Carbon metabolism_Homo sapiens_hsa012001.05484047
60Dilated cardiomyopathy_Homo sapiens_hsa054141.05483580
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04378821
62Basal cell carcinoma_Homo sapiens_hsa052171.03277449
63Renal cell carcinoma_Homo sapiens_hsa052111.01405900
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99945707
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99897072
66Arginine and proline metabolism_Homo sapiens_hsa003300.98573652
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93682815
68AMPK signaling pathway_Homo sapiens_hsa041520.92794927
69Small cell lung cancer_Homo sapiens_hsa052220.92396115
70Arginine biosynthesis_Homo sapiens_hsa002200.92068108
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.91858657
72Type II diabetes mellitus_Homo sapiens_hsa049300.91665975
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.89170932
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88344747
75Colorectal cancer_Homo sapiens_hsa052100.88261883
76Alcoholism_Homo sapiens_hsa050340.87743134
77VEGF signaling pathway_Homo sapiens_hsa043700.86308198
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86163065
79Dorso-ventral axis formation_Homo sapiens_hsa043200.85988420
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.85002202
81Vibrio cholerae infection_Homo sapiens_hsa051100.84212786
82Choline metabolism in cancer_Homo sapiens_hsa052310.81657894
83Base excision repair_Homo sapiens_hsa034100.80746824
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80287899
85MAPK signaling pathway_Homo sapiens_hsa040100.80040492
86Ras signaling pathway_Homo sapiens_hsa040140.79790141
87Rap1 signaling pathway_Homo sapiens_hsa040150.79621667
88Collecting duct acid secretion_Homo sapiens_hsa049660.78361158
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78187242
90mTOR signaling pathway_Homo sapiens_hsa041500.77110946
91Lysine degradation_Homo sapiens_hsa003100.76426383
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.76318233
93Non-small cell lung cancer_Homo sapiens_hsa052230.75755404
94Cell cycle_Homo sapiens_hsa041100.75659332
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74728239
96Protein digestion and absorption_Homo sapiens_hsa049740.74113683
97* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73935825
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72985399
99Tight junction_Homo sapiens_hsa045300.71757575
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71521205
101Pyruvate metabolism_Homo sapiens_hsa006200.70494073
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68445112
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67366204
104Focal adhesion_Homo sapiens_hsa045100.63534589
105Melanoma_Homo sapiens_hsa052180.63427992
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63172369
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.62853076
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62687509
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62318986
110Bladder cancer_Homo sapiens_hsa052190.61880148
111Thyroid hormone synthesis_Homo sapiens_hsa049180.61444086
112Pyrimidine metabolism_Homo sapiens_hsa002400.60579186
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58739500
114Glucagon signaling pathway_Homo sapiens_hsa049220.58428800
115Pathways in cancer_Homo sapiens_hsa052000.58404650
116Insulin signaling pathway_Homo sapiens_hsa049100.58166146
117Endocytosis_Homo sapiens_hsa041440.58136078
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57735216
119Amoebiasis_Homo sapiens_hsa051460.57397119
120Proteoglycans in cancer_Homo sapiens_hsa052050.56791826
121Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53998399
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53112072
123Folate biosynthesis_Homo sapiens_hsa007900.50840409
124Ovarian steroidogenesis_Homo sapiens_hsa049130.50273928
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.49628499
126Prostate cancer_Homo sapiens_hsa052150.49553702
127* N-Glycan biosynthesis_Homo sapiens_hsa005100.49364820
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48500266
129Chronic myeloid leukemia_Homo sapiens_hsa052200.48429274
130* Galactose metabolism_Homo sapiens_hsa000520.48304199
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47996379
132Prion diseases_Homo sapiens_hsa050200.47823258
133MicroRNAs in cancer_Homo sapiens_hsa052060.46992357
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46414824
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46102596
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45882650
137Pancreatic secretion_Homo sapiens_hsa049720.44223628
138mRNA surveillance pathway_Homo sapiens_hsa030150.42847737
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42732318
140Pancreatic cancer_Homo sapiens_hsa052120.41026735
141Adherens junction_Homo sapiens_hsa045200.40895948

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