B4GALT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.48102319
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.48102319
3modulation by symbiont of host immune response (GO:0052553)5.48102319
4positive regulation by symbiont of host defense response (GO:0052509)5.48102319
5modulation by symbiont of host defense response (GO:0052031)5.48102319
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.48102319
7regulation of interferon-beta biosynthetic process (GO:0045357)4.30947465
8regulation of vitamin D biosynthetic process (GO:0060556)4.26098666
9macrophage activation involved in immune response (GO:0002281)4.17048613
10positive regulation of interferon-alpha production (GO:0032727)4.07387281
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.92782725
12regulation of interferon-alpha production (GO:0032647)3.91883993
13regulation of integrin activation (GO:0033623)3.77352686
14apoptotic cell clearance (GO:0043277)3.50368627
15negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.45579421
16low-density lipoprotein particle clearance (GO:0034383)3.44915435
17response to host immune response (GO:0052572)3.44559893
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44559893
19response to peptidoglycan (GO:0032494)3.39742439
20regulation of vitamin metabolic process (GO:0030656)3.38551436
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37516294
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.37516294
23regulation of cholesterol storage (GO:0010885)3.37245127
24immunoglobulin mediated immune response (GO:0016064)3.32424087
25antigen processing and presentation of endogenous antigen (GO:0019883)3.32011955
26germinal center formation (GO:0002467)3.29292412
27positive regulation of gamma-delta T cell activation (GO:0046645)3.29182949
28response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25111607
29response to host (GO:0075136)3.25111607
30response to host defenses (GO:0052200)3.25111607
31negative regulation of cell killing (GO:0031342)3.22760087
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22760087
33regulation of mononuclear cell migration (GO:0071675)3.22530367
34positive regulation of interferon-beta production (GO:0032728)3.13985575
35positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11810008
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.09447164
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.08738398
38regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.05463018
39cell adhesion mediated by integrin (GO:0033627)3.03805485
40neutrophil activation involved in immune response (GO:0002283)3.03630739
41regulation of B cell receptor signaling pathway (GO:0050855)3.02829003
42positive regulation of chemokine biosynthetic process (GO:0045080)3.01462482
43lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00393595
44L-alpha-amino acid transmembrane transport (GO:1902475)2.99837643
45detection of other organism (GO:0098543)2.97903847
46regulation of T-helper 2 cell differentiation (GO:0045628)2.97570102
47negative regulation of interleukin-12 production (GO:0032695)2.95224896
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95013301
49positive regulation of Cdc42 GTPase activity (GO:0043089)2.94656197
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.93337842
51response to muramyl dipeptide (GO:0032495)2.90649817
52regulation of NFAT protein import into nucleus (GO:0051532)2.90221149
53response to type I interferon (GO:0034340)2.85841656
54regulation of chemokine biosynthetic process (GO:0045073)2.84901568
55type I interferon signaling pathway (GO:0060337)2.84724638
56cellular response to type I interferon (GO:0071357)2.84724638
57T-helper 1 type immune response (GO:0042088)2.84662838
58I-kappaB phosphorylation (GO:0007252)2.82141294
59negative regulation of erythrocyte differentiation (GO:0045647)2.80630146
60interferon-gamma-mediated signaling pathway (GO:0060333)2.80379438
61stress fiber assembly (GO:0043149)2.80082589
62detection of external biotic stimulus (GO:0098581)2.78940304
63regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78818068
64positive regulation of p38MAPK cascade (GO:1900745)2.78202931
65regulation of cytokine secretion involved in immune response (GO:0002739)2.76830249
66regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76829864
67positive regulation of cellular amide metabolic process (GO:0034250)2.72939929
68regulation of fever generation (GO:0031620)2.72187328
69leukocyte cell-cell adhesion (GO:0007159)2.71074638
70JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.71028645
71regulation of membrane protein ectodomain proteolysis (GO:0051043)2.70635437
72chronic inflammatory response (GO:0002544)2.69872795
73positive regulation of type 2 immune response (GO:0002830)2.66290445
74negative regulation of toll-like receptor signaling pathway (GO:0034122)2.65227358
75positive regulation of toll-like receptor signaling pathway (GO:0034123)2.64525833
76cellular response to lipopolysaccharide (GO:0071222)2.62789737
77response to interferon-alpha (GO:0035455)2.61347429
78cellular extravasation (GO:0045123)2.60230539
79modulation by symbiont of host cellular process (GO:0044068)2.59363259
80branching involved in labyrinthine layer morphogenesis (GO:0060670)2.58851796
81macrophage activation (GO:0042116)2.58275401
82positive regulation of heat generation (GO:0031652)2.58229283
83detection of molecule of bacterial origin (GO:0032490)2.58065729
84hypotonic response (GO:0006971)2.57918001
85production of molecular mediator involved in inflammatory response (GO:0002532)2.57737173
86establishment of endothelial barrier (GO:0061028)2.57243280
87response to laminar fluid shear stress (GO:0034616)2.57145852
88positive regulation of transcription factor import into nucleus (GO:0042993)2.56978673
89cellular response to molecule of bacterial origin (GO:0071219)2.56837888
90positive regulation of antigen processing and presentation (GO:0002579)2.56653334
91detection of biotic stimulus (GO:0009595)2.56349601
92respiratory burst (GO:0045730)2.56100531
93regulation of macrophage cytokine production (GO:0010935)2.54956382
94detection of bacterium (GO:0016045)2.54624505
95positive regulation of nitric oxide biosynthetic process (GO:0045429)2.54028039
96regulation of podosome assembly (GO:0071801)2.53911020
97regulation of interleukin-8 biosynthetic process (GO:0045414)2.52111163
98regulation of macrophage chemotaxis (GO:0010758)2.52043327
99myeloid dendritic cell differentiation (GO:0043011)2.51918283
100barbed-end actin filament capping (GO:0051016)2.51510878
101positive regulation of NF-kappaB import into nucleus (GO:0042346)2.49624106
102regulation of toll-like receptor signaling pathway (GO:0034121)2.49433235
103myeloid cell activation involved in immune response (GO:0002275)2.48985641
104regulation of type 2 immune response (GO:0002828)2.48977910
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.48616015
106positive regulation of macrophage cytokine production (GO:0060907)2.48603006
107granulocyte activation (GO:0036230)2.47737257
108regulation of chronic inflammatory response (GO:0002676)2.47683645
109regulation of interferon-beta production (GO:0032648)2.47194838
110regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47069550
111cellular response to thyroid hormone stimulus (GO:0097067)2.46544143
112activation of MAPKKK activity (GO:0000185)2.46544066
113regulation of necroptotic process (GO:0060544)2.46503240
114B cell mediated immunity (GO:0019724)2.45049548
115basic amino acid transport (GO:0015802)2.44035699
116Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43430138
117negative regulation of cytokine production involved in immune response (GO:0002719)2.42344778
118regulation of leukocyte degranulation (GO:0043300)2.41945378
119cellular response to interferon-alpha (GO:0035457)2.41630476
120cellular response to virus (GO:0098586)2.41531843
121regulation of gamma-delta T cell activation (GO:0046643)2.40866582
122modification by symbiont of host morphology or physiology (GO:0044003)2.40704519
123natural killer cell mediated cytotoxicity (GO:0042267)2.39779023
124natural killer cell mediated immunity (GO:0002228)2.39779023
125regulation of T-helper 1 cell differentiation (GO:0045625)2.39339483
126lipoprotein transport (GO:0042953)2.38722454
127response to manganese ion (GO:0010042)2.38456972
1283-UTR-mediated mRNA stabilization (GO:0070935)2.38293066
129mature B cell differentiation (GO:0002335)2.38198684
130leukocyte aggregation (GO:0070486)2.37851031
131positive regulation of interleukin-6 production (GO:0032755)2.36741526
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.36200810
133lymphocyte chemotaxis (GO:0048247)2.35840630
134regulation of apoptotic cell clearance (GO:2000425)2.35764638
135positive regulation of leukocyte degranulation (GO:0043302)2.35731149
136regulation of nitric oxide biosynthetic process (GO:0045428)2.34878642
137microglial cell activation (GO:0001774)2.34569148
138hydrogen peroxide biosynthetic process (GO:0050665)2.34471959
139pinocytosis (GO:0006907)2.32738218
140regulation of early endosome to late endosome transport (GO:2000641)2.32406665
141positive regulation of mast cell activation (GO:0033005)2.32169618
142regulation of gamma-delta T cell differentiation (GO:0045586)2.31091494
143protein localization to endosome (GO:0036010)2.30093645
144cellular response to interferon-gamma (GO:0071346)2.29820208
145T cell migration (GO:0072678)2.29156097
146NIK/NF-kappaB signaling (GO:0038061)2.28862951
147negative regulation of lipid storage (GO:0010888)2.28838803
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.28076591
149positive regulation of lipid storage (GO:0010884)2.27742691
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.27101102

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.56124123
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.43923339
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.12821584
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.62851414
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.14559494
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13134307
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.12101294
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10823354
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98570116
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.85139073
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.81933236
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.69873772
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.58276413
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43373173
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42194311
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28483024
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21839570
18* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15878010
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13075662
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00379464
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.00134753
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98370225
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97027889
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92484242
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89890640
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.85516442
27MYC_22102868_ChIP-Seq_BL_Human1.82028722
28* TCF7_22412390_ChIP-Seq_EML_Mouse1.80900792
29VDR_21846776_ChIP-Seq_THP-1_Human1.80648888
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.80262216
31MAF_26560356_Chip-Seq_TH1_Human1.77896540
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75765264
33KDM2B_26808549_Chip-Seq_DND41_Human1.72099582
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.71866505
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71701642
36* LXR_22158963_ChIP-Seq_LIVER_Mouse1.69098882
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67665118
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65641466
39SPI1_23127762_ChIP-Seq_K562_Human1.65607338
40* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65516683
41VDR_24763502_ChIP-Seq_THP-1_Human1.59294154
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57992599
43LXR_22292898_ChIP-Seq_THP-1_Human1.55468152
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.54683383
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51054530
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49920923
47RUNX_20019798_ChIP-Seq_JUKART_Human1.41551430
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.39883653
49UTX_26944678_Chip-Seq_JUKART_Human1.39570431
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39244858
51MYB_26560356_Chip-Seq_TH2_Human1.38039001
52VDR_24787735_ChIP-Seq_THP-1_Human1.37427550
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35132682
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34303213
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.33866859
56SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33635819
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33380103
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33053956
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32926900
60PU_27001747_Chip-Seq_BMDM_Mouse1.32912745
61MYB_26560356_Chip-Seq_TH1_Human1.32721625
62CLOCK_20551151_ChIP-Seq_293T_Human1.31355656
63RACK7_27058665_Chip-Seq_MCF-7_Human1.30572626
64* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30044143
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28696260
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26782417
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.25787420
68* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25335301
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25196119
70ZNF263_19887448_ChIP-Seq_K562_Human1.24306444
71* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22487796
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22310010
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22310010
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22310010
75SPI1_23547873_ChIP-Seq_NB4_Human1.22025396
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20701157
77NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20166213
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.20023206
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19749729
80SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19389680
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17864645
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15410634
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.15393177
84UBF1/2_26484160_Chip-Seq_HMECs_Human1.15206738
85KDM2B_26808549_Chip-Seq_JURKAT_Human1.14642917
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14021049
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13712270
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.13272424
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12611770
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12430030
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12094448
92* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10346396
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.08914363
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08015342
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07980378
96KDM2B_26808549_Chip-Seq_K562_Human1.07122303
97* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05971303
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05800206
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05240788
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05161657
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03845073
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01953412
103GATA1_22025678_ChIP-Seq_K562_Human1.01118201
104EGR1_19032775_ChIP-ChIP_M12_Human1.00851022
105ATF3_27146783_Chip-Seq_COLON_Human1.00697437
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00293847
107SCL_19346495_ChIP-Seq_HPC-7_Human1.00132771
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00115119
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.99800159
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.99800159
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99649098
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99521469
113GATA1_19941826_ChIP-Seq_K562_Human0.99372835
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98966455
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98591784
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97719000
117ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96090380
118GATA2_19941826_ChIP-Seq_K562_Human0.94958953
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.94274707
120NCOR1_26117541_ChIP-Seq_K562_Human0.93955165
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92626765
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89956656
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89910969
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89568309
125MAF_26560356_Chip-Seq_TH2_Human0.89218897
126GATA6_25053715_ChIP-Seq_YYC3_Human0.89113898
127* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89080241
128SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85087112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.79901456
2MP0003436_decreased_susceptibility_to3.16573885
3MP0003705_abnormal_hypodermis_morpholog3.10606261
4MP0005451_abnormal_body_composition3.09695625
5MP0005058_abnormal_lysosome_morphology3.02173022
6MP0004510_myositis2.88496031
7MP0001835_abnormal_antigen_presentation2.81862474
8MP0006082_CNS_inflammation2.79926201
9MP0009840_abnormal_foam_cell2.78887710
10MP0003300_gastrointestinal_ulcer2.72326139
11MP0005360_urolithiasis2.55549989
12MP0000569_abnormal_digit_pigmentation2.55102328
13MP0003172_abnormal_lysosome_physiology2.47453032
14MP0005387_immune_system_phenotype2.32941520
15MP0001790_abnormal_immune_system2.32941520
16MP0005000_abnormal_immune_tolerance2.24118827
17MP0002419_abnormal_innate_immunity2.20423060
18MP0009785_altered_susceptibility_to2.18870751
19MP0010352_gastrointestinal_tract_polyps2.14214708
20MP0000685_abnormal_immune_system2.09085053
21MP0009278_abnormal_bone_marrow2.02893698
22MP0005025_abnormal_response_to2.02603153
23MP0005076_abnormal_cell_differentiation1.97803728
24MP0002452_abnormal_antigen_presenting1.96540700
25MP0001800_abnormal_humoral_immune1.96467199
26MP0002148_abnormal_hypersensitivity_rea1.88011431
27MP0003448_altered_tumor_morphology1.84695479
28MP0003191_abnormal_cellular_cholesterol1.82959518
29MP0005257_abnormal_intraocular_pressure1.81568338
30MP0005464_abnormal_platelet_physiology1.81568239
31MP0004947_skin_inflammation1.80877360
32MP0001533_abnormal_skeleton_physiology1.76428077
33MP0003566_abnormal_cell_adhesion1.76101009
34MP0002139_abnormal_hepatobiliary_system1.75693701
35MP0002723_abnormal_immune_serum1.72996546
36MP0003828_pulmonary_edema1.72773214
37MP0003656_abnormal_erythrocyte_physiolo1.67376025
38MP0004858_abnormal_nervous_system1.61947466
39MP0004185_abnormal_adipocyte_glucose1.60927217
40MP0003724_increased_susceptibility_to1.60496367
41MP0000604_amyloidosis1.60366639
42MP0001819_abnormal_immune_cell1.58421805
43MP0002332_abnormal_exercise_endurance1.58403914
44MP0008438_abnormal_cutaneous_collagen1.56910934
45MP0010234_abnormal_vibrissa_follicle1.56250048
46MP0002420_abnormal_adaptive_immunity1.56091879
47MP0002405_respiratory_system_inflammati1.55886576
48MP0001849_ear_inflammation1.51723064
49MP0003091_abnormal_cell_migration1.51282997
50MP0003075_altered_response_to1.51128324
51MP0001845_abnormal_inflammatory_respons1.49304336
52MP0010307_abnormal_tumor_latency1.46348200
53MP0005023_abnormal_wound_healing1.43272408
54MP0008260_abnormal_autophagy1.42962889
55MP0005671_abnormal_response_to1.42600052
56MP0001958_emphysema1.40020411
57MP0002998_abnormal_bone_remodeling1.39136499
58MP0010155_abnormal_intestine_physiology1.38915755
59MP0004233_abnormal_muscle_weight1.34630207
60MP0008469_abnormal_protein_level1.31942003
61MP0000343_altered_response_to1.29678296
62MP0008004_abnormal_stomach_pH1.28890489
63MP0002877_abnormal_melanocyte_morpholog1.22896628
64MP0002138_abnormal_hepatobiliary_system1.21734318
65MP0009764_decreased_sensitivity_to1.19750052
66MP0005167_abnormal_blood-brain_barrier1.19501111
67MP0003045_fibrosis1.19357149
68MP0000858_altered_metastatic_potential1.19128711
69MP0003329_amyloid_beta_deposits1.18835013
70MP0009333_abnormal_splenocyte_physiolog1.15937696
71MP0000716_abnormal_immune_system1.14575690
72MP0005166_decreased_susceptibility_to1.14470973
73MP0003252_abnormal_bile_duct1.10602046
74MP0002398_abnormal_bone_marrow1.10339947
75MP0005409_darkened_coat_color1.07912912
76MP0000689_abnormal_spleen_morphology1.07643055
77MP0001915_intracranial_hemorrhage1.07440281
78MP0005666_abnormal_adipose_tissue1.07032532
79MP0008961_abnormal_basal_metabolism1.03383329
80MP0003279_aneurysm1.02419029
81MP0001545_abnormal_hematopoietic_system0.99232371
82MP0005397_hematopoietic_system_phenotyp0.99232371
83MP0003221_abnormal_cardiomyocyte_apopto0.97093478
84MP0002722_abnormal_immune_system0.96798860
85MP0002429_abnormal_blood_cell0.94423077
86MP0002136_abnormal_kidney_physiology0.94125529
87MP0000609_abnormal_liver_physiology0.94101597
88MP0003453_abnormal_keratinocyte_physiol0.93703242
89MP0005310_abnormal_salivary_gland0.93633999
90MP0000249_abnormal_blood_vessel0.93488129
91MP0000371_diluted_coat_color0.92603684
92MP0005390_skeleton_phenotype0.91922226
93MP0002254_reproductive_system_inflammat0.91010350
94MP0003183_abnormal_peptide_metabolism0.90195345
95MP0001853_heart_inflammation0.89724484
96MP0005164_abnormal_response_to0.89542498
97MP0001851_eye_inflammation0.88861898
98MP0005165_increased_susceptibility_to0.88306541
99MP0002166_altered_tumor_susceptibility0.88039197
100MP0006054_spinal_hemorrhage0.86608288
101MP0002168_other_aberrant_phenotype0.86315930
102MP0000767_abnormal_smooth_muscle0.86032641
103MP0003950_abnormal_plasma_membrane0.83999780
104MP0002933_joint_inflammation0.82949481
105MP0005083_abnormal_biliary_tract0.80288048
106MP0002006_tumorigenesis0.79775862
107MP0008875_abnormal_xenobiotic_pharmacok0.79580463
108MP0004264_abnormal_extraembryonic_tissu0.79547502
109MP0000733_abnormal_muscle_development0.79504806
110MP0005621_abnormal_cell_physiology0.79321582
111MP0005623_abnormal_meninges_morphology0.78503170
112MP0004019_abnormal_vitamin_homeostasis0.78055324
113MP0009763_increased_sensitivity_to0.77830137
114MP0004808_abnormal_hematopoietic_stem0.77368266
115MP0005174_abnormal_tail_pigmentation0.77116234
116MP0010329_abnormal_lipoprotein_level0.77096143
117MP0000598_abnormal_liver_morphology0.76197227
118MP0003941_abnormal_skin_development0.75894070
119MP0004272_abnormal_basement_membrane0.75017022
120MP0005319_abnormal_enzyme/_coenzyme0.74744076
121MP0003690_abnormal_glial_cell0.74109026
122MP0009643_abnormal_urine_homeostasis0.71441329
123MP0004883_abnormal_blood_vessel0.70976627
124MP0005375_adipose_tissue_phenotype0.70963920
125MP0001348_abnormal_lacrimal_gland0.68616025
126MP0000920_abnormal_myelination0.68219927
127MP0002896_abnormal_bone_mineralization0.68193762
128MP0001216_abnormal_epidermal_layer0.67336444
129MP0005248_abnormal_Harderian_gland0.65301819

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.28793211
2Eczematoid dermatitis (HP:0000976)4.19648927
3Increased cerebral lipofuscin (HP:0011813)4.08876807
4Systemic lupus erythematosus (HP:0002725)3.93051744
5Recurrent gram-negative bacterial infections (HP:0005420)3.92909737
6Recurrent bacterial skin infections (HP:0005406)3.79463898
7Autoimmune thrombocytopenia (HP:0001973)3.64946062
8Dysostosis multiplex (HP:0000943)3.41295860
9Myocardial infarction (HP:0001658)3.36433169
10Vacuolated lymphocytes (HP:0001922)3.35091266
11Mucopolysacchariduria (HP:0008155)3.29029231
12Urinary glycosaminoglycan excretion (HP:0003541)3.29029231
13Abnormality of macrophages (HP:0004311)3.28319626
14Neurofibrillary tangles (HP:0002185)3.19022595
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.13210456
16Abnormality of mucopolysaccharide metabolism (HP:0011020)3.07294077
17Abnormality of polysaccharide metabolism (HP:0011012)3.07294077
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.07294077
19Orchitis (HP:0100796)2.89194539
20Cerebral inclusion bodies (HP:0100314)2.89159520
21Axonal loss (HP:0003447)2.84314183
22Myositis (HP:0100614)2.84012438
23Gingivitis (HP:0000230)2.83486073
24Mediastinal lymphadenopathy (HP:0100721)2.81782842
25Elevated erythrocyte sedimentation rate (HP:0003565)2.80602772
26Peritonitis (HP:0002586)2.74189978
27Disinhibition (HP:0000734)2.62108600
28Keratoconjunctivitis sicca (HP:0001097)2.58889049
29Abnormality of liposaccharide metabolism (HP:0010968)2.53123028
30Abnormality of glycosphingolipid metabolism (HP:0004343)2.53123028
31Abnormality of glycolipid metabolism (HP:0010969)2.53123028
32Cerebral aneurysm (HP:0004944)2.49722493
33Glomerulonephritis (HP:0000099)2.49491450
34Recurrent fungal infections (HP:0002841)2.45556410
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.44610294
36Nasal polyposis (HP:0100582)2.43944325
37Increased connective tissue (HP:0009025)2.40779054
38Periodontitis (HP:0000704)2.39253334
39Stomatitis (HP:0010280)2.37536628
40Cervical subluxation (HP:0003308)2.35433026
41Pustule (HP:0200039)2.33627961
42Segmental peripheral demyelination/remyelination (HP:0003481)2.31590640
43Arterial thrombosis (HP:0004420)2.30663026
44Loss of speech (HP:0002371)2.30137991
45Interstitial pulmonary disease (HP:0006530)2.30117009
46Nephritis (HP:0000123)2.27525461
47Abnormality of the nasal mucosa (HP:0000433)2.26770574
48Increased CSF protein (HP:0002922)2.26282868
49Abnormality of complement system (HP:0005339)2.25324216
50Vertebral compression fractures (HP:0002953)2.24902043
51Nuclear cataract (HP:0100018)2.24808717
52Recurrent skin infections (HP:0001581)2.24005967
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.23773122
54Upper motor neuron abnormality (HP:0002127)2.20503312
55Cellulitis (HP:0100658)2.20404531
56Keratoconjunctivitis (HP:0001096)2.18542054
57Esophageal varix (HP:0002040)2.17999869
58Hand muscle atrophy (HP:0009130)2.15373893
59Recurrent viral infections (HP:0004429)2.15084809
60Arterial tortuosity (HP:0005116)2.14930910
61Hematochezia (HP:0002573)2.13830592
62Hyperacusis (HP:0010780)2.13378506
63Complement deficiency (HP:0004431)2.12669658
64Vasculitis (HP:0002633)2.12534973
65Distal upper limb amyotrophy (HP:0007149)2.08876931
66Upper limb amyotrophy (HP:0009129)2.08876931
67Protrusio acetabuli (HP:0003179)2.05642465
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.03819501
69Osteolytic defects of the hand bones (HP:0009699)2.03819501
70Retrobulbar optic neuritis (HP:0100654)2.03489447
71Optic neuritis (HP:0100653)2.03489447
72Frequent falls (HP:0002359)2.03274863
73Xanthomatosis (HP:0000991)2.03237092
74Hydroxyprolinuria (HP:0003080)2.02705461
75Abnormality of proline metabolism (HP:0010907)2.02705461
76Deep venous thrombosis (HP:0002625)1.99058024
77Menorrhagia (HP:0000132)1.98656045
78Gingival bleeding (HP:0000225)1.96324295
79Mitral stenosis (HP:0001718)1.95657498
80Basal ganglia calcification (HP:0002135)1.95482103
81Pulmonary infiltrates (HP:0002113)1.94840578
82Neuronal loss in central nervous system (HP:0002529)1.93284350
83Centrally nucleated skeletal muscle fibers (HP:0003687)1.92658051
84Joint hemorrhage (HP:0005261)1.92654913
85Distal lower limb amyotrophy (HP:0008944)1.92287220
86Increased density of long bones (HP:0006392)1.92279169
87Bilateral sensorineural hearing impairment (HP:0008619)1.91301383
88Asymmetric septal hypertrophy (HP:0001670)1.91281321
89Impaired platelet aggregation (HP:0003540)1.90812950
90Abnormal platelet function (HP:0011869)1.90812950
91Pathologic fracture (HP:0002756)1.89020220
92Vascular tortuosity (HP:0004948)1.88940530
93Abnormal platelet volume (HP:0011876)1.87317939
94Chronic obstructive pulmonary disease (HP:0006510)1.86705694
95Obstructive lung disease (HP:0006536)1.86705694
96Spontaneous hematomas (HP:0007420)1.86679052
97Apathy (HP:0000741)1.86607384
98Global brain atrophy (HP:0002283)1.85996976
99Flat acetabular roof (HP:0003180)1.85719635
100Subacute progressive viral hepatitis (HP:0006572)1.85180173
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.84852090
102Tetraparesis (HP:0002273)1.84317428
103Diminished motivation (HP:0000745)1.84210554
104Colitis (HP:0002583)1.84042564
105Gastrointestinal infarctions (HP:0005244)1.82985363
106Mitral valve prolapse (HP:0001634)1.82352030
107Distal lower limb muscle weakness (HP:0009053)1.82211741
108Coarse hair (HP:0002208)1.81697185
109Increased mean platelet volume (HP:0011877)1.81051477
110Urticaria (HP:0001025)1.80992843
111Aseptic necrosis (HP:0010885)1.80156506
112Amyloidosis (HP:0011034)1.78160418
113Achilles tendon contracture (HP:0001771)1.78108809
114Muscle fiber splitting (HP:0003555)1.78096427
115Increased serum ferritin (HP:0003281)1.78083380
116Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77185314
117Spondylolisthesis (HP:0003302)1.76541280
118Thin bony cortex (HP:0002753)1.76306067
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75187256
120Bone pain (HP:0002653)1.74983661
121Premature rupture of membranes (HP:0001788)1.74906433
122Insomnia (HP:0100785)1.73012329
123Absent frontal sinuses (HP:0002688)1.72809505
124Polygenic inheritance (HP:0010982)1.71903195
125Difficulty climbing stairs (HP:0003551)1.71364439
126Supranuclear gaze palsy (HP:0000605)1.67507782
127Abnormality of the distal phalanges of the toes (HP:0010182)1.64478247
128Slow saccadic eye movements (HP:0000514)1.63785199
129Asymmetry of the thorax (HP:0001555)1.63270973
130Fatigue (HP:0012378)1.63255553
131Thoracic kyphosis (HP:0002942)1.61549302
132Abnormality of the endocardium (HP:0004306)1.61121789
133Decreased motor nerve conduction velocity (HP:0003431)1.60991926
134Insidious onset (HP:0003587)1.60601468
135Termporal pattern (HP:0011008)1.60601468
136Thoracolumbar scoliosis (HP:0002944)1.60469974
137Ankyloglossia (HP:0010296)1.58695118
138Abnormality of the thoracic spine (HP:0100711)1.58112673
139Spinal cord lesions (HP:0100561)1.58062816
140Syringomyelia (HP:0003396)1.58062816
141Aneurysm (HP:0002617)1.57381781
142Polycythemia (HP:0001901)1.57133505
143Abnormality of skeletal muscle fiber size (HP:0012084)1.56387175
144Hyperparathyroidism (HP:0000843)1.56345736
145Abnormality of the Achilles tendon (HP:0005109)1.53990287
146Short nail (HP:0001799)1.53609434
147Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.53376490
148Long palpebral fissure (HP:0000637)1.53244693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.64606161
2PRPF4B3.44863102
3TRIB33.19214986
4MAP4K12.77577670
5MAP3K142.49723919
6TBK12.46019664
7RIPK12.44696378
8MAP3K102.33963839
9PKN22.27207026
10TYK22.25488487
11SMG12.17213410
12RIPK42.12696843
13CDK122.08285887
14BLK2.01687671
15BMX1.89885900
16JAK31.77687694
17JAK11.73601201
18GRK61.73363390
19STK101.71888322
20NME21.65357532
21CSK1.65351792
22PTK61.56156251
23EPHA21.55419464
24FGFR41.54062336
25DDR21.50722707
26EPHB11.43336864
27IKBKE1.40727643
28IKBKB1.39905717
29CDC42BPA1.37234636
30SIK21.36386463
31KIT1.35587641
32FGR1.32324600
33ZAP701.30858620
34MAP3K111.30589239
35TGFBR21.29598654
36IRAK31.29371011
37TTN1.27543771
38PDGFRA1.26587044
39MAP3K131.24881694
40LRRK21.24377815
41MAP3K91.23320826
42FGFR31.21173306
43IRAK21.19542640
44HCK1.17424702
45MATK1.11687959
46TAOK11.09899960
47IRAK41.09568936
48CHUK1.08976803
49PIM11.06533496
50KSR21.06166361
51EPHA31.02529870
52ALK1.00251266
53GRK71.00150163
54JAK20.99222017
55CSF1R0.98402250
56TAOK30.97505451
57YES10.95605977
58MOS0.93553219
59PTK20.91961470
60MAP2K30.91416386
61EEF2K0.89975106
62IRAK10.88359596
63PIM20.87526611
64SYK0.86099535
65MAP3K60.83174463
66CAMK1D0.82200492
67MARK30.82086919
68SCYL20.81933404
69MST1R0.79671444
70MAP3K50.77391283
71EGFR0.74087222
72BMPR20.74053864
73NEK90.73730430
74PRKG20.73666586
75STK240.73559794
76CDK60.73058820
77LCK0.73005326
78PAK40.72894789
79ERBB40.72324060
80MAP3K30.72181129
81TXK0.71714477
82SIK30.69862305
83KSR10.69583777
84CLK10.69496344
85GSK3A0.68695658
86SIK10.67696727
87PDGFRB0.67638485
88ABL20.67610374
89MAP3K10.67554554
90LATS20.67459465
91MARK20.66572291
92RPS6KA40.65919672
93CAMK1G0.64973677
94FES0.62676348
95CAMKK10.61900378
96PRKCH0.60563674
97RET0.59670407
98TRPM70.57522396
99MET0.57519645
100ITK0.56727808
101TAOK20.56453808
102ARAF0.53493702
103PDPK10.52880831
104STK30.52596984
105ABL10.52234577
106MTOR0.51481784
107SGK30.50053865
108ICK0.49730731
109LYN0.48160612
110BRD40.47922283
111BTK0.46431453
112DAPK20.46389372
113STK380.46130535
114DMPK0.43522463
115MAP3K80.42000849
116CDK40.41854400
117NTRK10.41023741
118MAP3K20.39924446
119TYRO30.39720418
120PDK10.38265007
121DYRK30.38070007
122RPS6KA20.37992205
123PRKD20.37901237
124HIPK20.37846455
125INSR0.37493623
126MELK0.36279407
127WNK10.35635594
128LATS10.35459404
129RPS6KC10.34667936

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.82281508
2Leishmaniasis_Homo sapiens_hsa051402.61779693
3Osteoclast differentiation_Homo sapiens_hsa043802.09318510
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08036263
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.94835705
6Tuberculosis_Homo sapiens_hsa051521.82872198
7Lysosome_Homo sapiens_hsa041421.78657251
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.74690623
9Malaria_Homo sapiens_hsa051441.70621297
10Pertussis_Homo sapiens_hsa051331.69019834
11Graft-versus-host disease_Homo sapiens_hsa053321.68547139
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65667219
13TNF signaling pathway_Homo sapiens_hsa046681.60250747
14B cell receptor signaling pathway_Homo sapiens_hsa046621.56551156
15Legionellosis_Homo sapiens_hsa051341.53828119
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47586487
17Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45309245
18Toxoplasmosis_Homo sapiens_hsa051451.44145079
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40569931
20Complement and coagulation cascades_Homo sapiens_hsa046101.40120014
21Measles_Homo sapiens_hsa051621.38622001
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35601484
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34655300
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32408038
25Antigen processing and presentation_Homo sapiens_hsa046121.31743994
26Influenza A_Homo sapiens_hsa051641.30812764
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28619791
28Renal cell carcinoma_Homo sapiens_hsa052111.27783305
29Shigellosis_Homo sapiens_hsa051311.27408293
30Allograft rejection_Homo sapiens_hsa053301.26086407
31Apoptosis_Homo sapiens_hsa042101.25674260
32Salmonella infection_Homo sapiens_hsa051321.24691791
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22113390
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21403976
35Chronic myeloid leukemia_Homo sapiens_hsa052201.20260643
36Phagosome_Homo sapiens_hsa041451.16135809
37Viral myocarditis_Homo sapiens_hsa054161.15721568
38Other glycan degradation_Homo sapiens_hsa005111.14733168
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13340316
40Caffeine metabolism_Homo sapiens_hsa002321.12492878
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12404317
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09835995
43Amoebiasis_Homo sapiens_hsa051461.08973751
44Arginine biosynthesis_Homo sapiens_hsa002201.08421459
45Rheumatoid arthritis_Homo sapiens_hsa053231.07970457
46Chemokine signaling pathway_Homo sapiens_hsa040621.04235794
47Acute myeloid leukemia_Homo sapiens_hsa052211.03274010
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.03126819
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.03119540
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02545492
51Endometrial cancer_Homo sapiens_hsa052131.02212528
52Hepatitis C_Homo sapiens_hsa051601.00887399
53Hepatitis B_Homo sapiens_hsa051611.00880966
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99931524
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.99151912
56Pancreatic cancer_Homo sapiens_hsa052120.99026899
57Proteoglycans in cancer_Homo sapiens_hsa052050.94403533
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94307501
59Nitrogen metabolism_Homo sapiens_hsa009100.94258721
60ErbB signaling pathway_Homo sapiens_hsa040120.91193619
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.90439073
62Thyroid cancer_Homo sapiens_hsa052160.89482810
63Prostate cancer_Homo sapiens_hsa052150.88049123
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.85721520
65African trypanosomiasis_Homo sapiens_hsa051430.84273131
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.83833501
67Type I diabetes mellitus_Homo sapiens_hsa049400.82943329
68Prolactin signaling pathway_Homo sapiens_hsa049170.82675696
69Herpes simplex infection_Homo sapiens_hsa051680.80878084
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80260171
71VEGF signaling pathway_Homo sapiens_hsa043700.80051212
72mTOR signaling pathway_Homo sapiens_hsa041500.79858664
73T cell receptor signaling pathway_Homo sapiens_hsa046600.77045104
74Type II diabetes mellitus_Homo sapiens_hsa049300.76642106
75Bile secretion_Homo sapiens_hsa049760.75700204
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74648902
77Small cell lung cancer_Homo sapiens_hsa052220.74535301
78Hematopoietic cell lineage_Homo sapiens_hsa046400.74006176
79Insulin resistance_Homo sapiens_hsa049310.72655352
80Renin-angiotensin system_Homo sapiens_hsa046140.71902494
81GnRH signaling pathway_Homo sapiens_hsa049120.71880097
82Insulin signaling pathway_Homo sapiens_hsa049100.71388167
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.69350144
84FoxO signaling pathway_Homo sapiens_hsa040680.68048711
85Starch and sucrose metabolism_Homo sapiens_hsa005000.66659266
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66610017
87Platelet activation_Homo sapiens_hsa046110.65997658
88Mineral absorption_Homo sapiens_hsa049780.65031283
89Glioma_Homo sapiens_hsa052140.64324028
90Focal adhesion_Homo sapiens_hsa045100.63889343
91Dorso-ventral axis formation_Homo sapiens_hsa043200.62832231
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61919628
93Prion diseases_Homo sapiens_hsa050200.61090702
94HIF-1 signaling pathway_Homo sapiens_hsa040660.60329372
95Lysine degradation_Homo sapiens_hsa003100.59974904
96MicroRNAs in cancer_Homo sapiens_hsa052060.59952521
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59782610
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59460387
99Sphingolipid metabolism_Homo sapiens_hsa006000.58808722
100Bladder cancer_Homo sapiens_hsa052190.58520953
101Viral carcinogenesis_Homo sapiens_hsa052030.58490911
102Galactose metabolism_Homo sapiens_hsa000520.57552149
103Colorectal cancer_Homo sapiens_hsa052100.55946301
104Adherens junction_Homo sapiens_hsa045200.55806289
105HTLV-I infection_Homo sapiens_hsa051660.55760953
106Rap1 signaling pathway_Homo sapiens_hsa040150.55267229
107Epstein-Barr virus infection_Homo sapiens_hsa051690.54677335
108Estrogen signaling pathway_Homo sapiens_hsa049150.53580770
109Pathways in cancer_Homo sapiens_hsa052000.52426099
110Non-small cell lung cancer_Homo sapiens_hsa052230.51986553
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.51487736
112MAPK signaling pathway_Homo sapiens_hsa040100.50145329
113PPAR signaling pathway_Homo sapiens_hsa033200.49845459
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49646942
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48904012
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48586992
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.47599108
118Endocytosis_Homo sapiens_hsa041440.47585729
119Pentose phosphate pathway_Homo sapiens_hsa000300.46658034
120Choline metabolism in cancer_Homo sapiens_hsa052310.46078464
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45127845
122Asthma_Homo sapiens_hsa053100.44945394
123Notch signaling pathway_Homo sapiens_hsa043300.44060889
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41463170

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