B4GALT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.76616455
2vocalization behavior (GO:0071625)5.51226989
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.46802921
4synaptic vesicle maturation (GO:0016188)5.24001083
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.14431948
6locomotory exploration behavior (GO:0035641)5.11706719
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.07489413
8ionotropic glutamate receptor signaling pathway (GO:0035235)5.00874512
9synaptic vesicle exocytosis (GO:0016079)4.98945075
10neuron cell-cell adhesion (GO:0007158)4.81753196
11protein localization to synapse (GO:0035418)4.81639785
12regulation of glutamate receptor signaling pathway (GO:1900449)4.74284902
13regulation of synaptic vesicle exocytosis (GO:2000300)4.60319748
14neuronal action potential propagation (GO:0019227)4.58735115
15glutamate receptor signaling pathway (GO:0007215)4.42344753
16glutamate secretion (GO:0014047)4.39449762
17postsynaptic membrane organization (GO:0001941)4.32025078
18exploration behavior (GO:0035640)4.31921547
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22042706
20regulation of synaptic vesicle transport (GO:1902803)4.20702742
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.19497175
22synaptic transmission, glutamatergic (GO:0035249)4.18852429
23regulation of neuronal synaptic plasticity (GO:0048168)3.95606550
24neurotransmitter secretion (GO:0007269)3.94340983
25dendritic spine morphogenesis (GO:0060997)3.93722240
26layer formation in cerebral cortex (GO:0021819)3.92383028
27neuron-neuron synaptic transmission (GO:0007270)3.89696469
28proline transport (GO:0015824)3.87032095
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.85202513
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.83658900
31presynaptic membrane assembly (GO:0097105)3.80248019
32long-term memory (GO:0007616)3.79519598
33positive regulation of membrane potential (GO:0045838)3.76013000
34neurotransmitter-gated ion channel clustering (GO:0072578)3.73162285
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72279158
36regulation of synapse structural plasticity (GO:0051823)3.70014597
37neuron recognition (GO:0008038)3.62926421
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.54887316
39positive regulation of synaptic transmission, GABAergic (GO:0032230)3.53467402
40regulation of postsynaptic membrane potential (GO:0060078)3.53212362
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.52660827
42transmission of nerve impulse (GO:0019226)3.50963445
43gamma-aminobutyric acid transport (GO:0015812)3.47500720
44membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46053752
45positive regulation of dendritic spine development (GO:0060999)3.43642687
46presynaptic membrane organization (GO:0097090)3.41118236
47synaptic vesicle endocytosis (GO:0048488)3.39305433
48cellular potassium ion homeostasis (GO:0030007)3.36404365
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35365120
50neurotransmitter transport (GO:0006836)3.35305660
51response to histamine (GO:0034776)3.30785793
52G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.22938428
53auditory behavior (GO:0031223)3.21867096
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20513693
55regulation of synaptic plasticity (GO:0048167)3.19982298
56regulation of dendritic spine morphogenesis (GO:0061001)3.19055517
57axonal fasciculation (GO:0007413)3.17676009
58regulation of vesicle fusion (GO:0031338)3.17512757
59negative regulation of dendrite morphogenesis (GO:0050774)3.16645200
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.15031476
61synapse assembly (GO:0007416)3.14334464
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.13464506
63positive regulation of synapse maturation (GO:0090129)3.12801468
64regulation of synaptic transmission, glutamatergic (GO:0051966)3.10226807
65activation of protein kinase A activity (GO:0034199)3.09919006
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09833119
67regulation of neurotransmitter secretion (GO:0046928)3.09354824
68positive regulation of neurotransmitter secretion (GO:0001956)3.08987225
69long-term synaptic potentiation (GO:0060291)3.08774162
70regulation of meiosis I (GO:0060631)3.07501123
71mitotic sister chromatid cohesion (GO:0007064)3.06768702
72response to auditory stimulus (GO:0010996)3.06367660
73behavioral fear response (GO:0001662)3.06258207
74behavioral defense response (GO:0002209)3.06258207
75vesicle transport along microtubule (GO:0047496)3.04680703
76regulation of histone H3-K9 methylation (GO:0051570)3.04464937
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04437347
78neuromuscular process controlling posture (GO:0050884)3.03893079
79membrane depolarization (GO:0051899)3.02713140
80neuromuscular process controlling balance (GO:0050885)3.01285084
81learning (GO:0007612)2.99463644
82fear response (GO:0042596)2.99167368
83mechanosensory behavior (GO:0007638)2.98994157
84regulation of neurotransmitter levels (GO:0001505)2.98758612
85regulation of dendritic spine development (GO:0060998)2.98404649
86innervation (GO:0060384)2.95845505
87cerebellar Purkinje cell differentiation (GO:0021702)2.95271518
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93764994
89dendritic spine organization (GO:0097061)2.93563877
90membrane depolarization during action potential (GO:0086010)2.92906023
91startle response (GO:0001964)2.90866231
92positive regulation of histone H3-K4 methylation (GO:0051571)2.90737956
93sodium ion export (GO:0071436)2.89510317
94regulation of synaptic transmission, GABAergic (GO:0032228)2.88727069
95positive regulation of neurotransmitter transport (GO:0051590)2.87827703
96positive regulation of synapse assembly (GO:0051965)2.87243045
97neuronal ion channel clustering (GO:0045161)2.85479692
98intraspecies interaction between organisms (GO:0051703)2.84986243
99social behavior (GO:0035176)2.84986243
100dendrite morphogenesis (GO:0048813)2.84061926
101cell communication by electrical coupling (GO:0010644)2.84019503
102synaptic transmission (GO:0007268)2.82520778
103regulation of neurotransmitter transport (GO:0051588)2.81033833
104central nervous system projection neuron axonogenesis (GO:0021952)2.79541817
105righting reflex (GO:0060013)2.79146827
106piRNA metabolic process (GO:0034587)2.78746205
107membrane hyperpolarization (GO:0060081)2.77801176
108cerebellar granule cell differentiation (GO:0021707)2.76310195
109establishment of integrated proviral latency (GO:0075713)2.74234251
110dopamine transport (GO:0015872)2.71919097
111inositol phosphate catabolic process (GO:0071545)2.71730257
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.70006097
113synapsis (GO:0007129)2.66788848
114regulation of calcium ion-dependent exocytosis (GO:0017158)2.57187841
115detection of calcium ion (GO:0005513)2.54700232
116regulation of Rac protein signal transduction (GO:0035020)2.50807017
117ether lipid metabolic process (GO:0046485)2.48373644
118single strand break repair (GO:0000012)2.46944386
119DNA double-strand break processing (GO:0000729)2.46056627
120dopamine biosynthetic process (GO:0042416)2.43051185
121L-amino acid import (GO:0043092)2.42304351
122inositol phosphate dephosphorylation (GO:0046855)2.39630280
123phosphorylated carbohydrate dephosphorylation (GO:0046838)2.39630280
124atrial cardiac muscle cell action potential (GO:0086014)2.39138890
125neurotransmitter uptake (GO:0001504)2.38641906
126response to insecticide (GO:0017085)2.37381306
127potassium ion homeostasis (GO:0055075)2.36215954
128negative regulation of dendrite development (GO:2000171)2.35376983
129potassium ion import (GO:0010107)2.32782133
130regulation of voltage-gated calcium channel activity (GO:1901385)2.31988147
131cellular sodium ion homeostasis (GO:0006883)2.29607030
132response to amphetamine (GO:0001975)2.29420086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.69955206
2GBX2_23144817_ChIP-Seq_PC3_Human3.86247867
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10802248
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97218299
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79409267
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.70239873
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.59192953
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50114493
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50114493
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49937083
11E2F7_22180533_ChIP-Seq_HELA_Human2.46329669
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45575265
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.35787512
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34975267
15EWS_26573619_Chip-Seq_HEK293_Human2.29108370
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28303961
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27169299
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26113070
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25282677
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.23848608
21DROSHA_22980978_ChIP-Seq_HELA_Human2.11315864
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08178324
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07693250
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.05301555
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.05295206
26IGF1R_20145208_ChIP-Seq_DFB_Human2.02333741
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.00476056
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.99228816
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94908683
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93227017
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91337851
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.85272438
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84466074
34SMAD4_21799915_ChIP-Seq_A2780_Human1.82586149
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82389241
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81720928
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78622479
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78494729
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77706701
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.75981367
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74314300
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72874655
43TAF15_26573619_Chip-Seq_HEK293_Human1.71547285
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69433899
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66346519
46ZNF274_21170338_ChIP-Seq_K562_Hela1.63689683
47AR_21572438_ChIP-Seq_LNCaP_Human1.62763551
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58678282
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56842004
50P300_19829295_ChIP-Seq_ESCs_Human1.55891192
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54291758
52HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51546684
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50540270
54FUS_26573619_Chip-Seq_HEK293_Human1.45041167
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44423311
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41084832
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40884026
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40688848
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40154483
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.38072801
61RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36136422
62STAT3_23295773_ChIP-Seq_U87_Human1.35913120
63RNF2_27304074_Chip-Seq_NSC_Mouse1.34622681
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34240938
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33901406
66AR_25329375_ChIP-Seq_VCAP_Human1.33855236
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32733375
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.32265400
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26678936
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26644818
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.26227460
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25254105
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.24370664
74* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24111857
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22820503
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21931800
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21701979
78GATA1_26923725_Chip-Seq_HPCs_Mouse1.21635962
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20926034
80YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16781603
81SOX9_26525672_Chip-Seq_HEART_Mouse1.16310135
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15923884
83AR_19668381_ChIP-Seq_PC3_Human1.15636083
84* TCF4_23295773_ChIP-Seq_U87_Human1.15627331
85TP53_16413492_ChIP-PET_HCT116_Human1.14742351
86* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14516166
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.14167037
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13638352
89POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12528496
90TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12528496
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.12041732
92RUNX2_22187159_ChIP-Seq_PCA_Human1.12028963
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10574063
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10410424
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.09352519
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08794073
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08712715
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08502303
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07772406
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07296047
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07285663
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05740320
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.05478704
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04836532
105* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04707565
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.04445261
107* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04361806
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04329770
109CBP_20019798_ChIP-Seq_JUKART_Human1.04329770
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04307615
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02901282
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02757248
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02271044
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.01038109
115FLI1_21867929_ChIP-Seq_TH2_Mouse1.00505478
116* SOX2_16153702_ChIP-ChIP_HESCs_Human1.00243776
117PRDM14_20953172_ChIP-Seq_ESCs_Human0.98624943
118TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98266314
119AHR_22903824_ChIP-Seq_MCF-7_Human0.98019742
120VDR_22108803_ChIP-Seq_LS180_Human0.97863734
121SMAD3_21741376_ChIP-Seq_ESCs_Human0.97477107
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.97256242
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97253637
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97243693
125JUN_21703547_ChIP-Seq_K562_Human0.96643262
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96542941
127TCF4_22108803_ChIP-Seq_LS180_Human0.96039167
128PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95781914
129TP53_18474530_ChIP-ChIP_U2OS_Human0.95709901
130REST_19997604_ChIP-ChIP_NEURONS_Mouse0.95495439
131ER_23166858_ChIP-Seq_MCF-7_Human0.94890584
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.93923130
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.93585270
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93071250
135* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91868568
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91183461
137P53_22387025_ChIP-Seq_ESCs_Mouse0.90008678
138BCAT_22108803_ChIP-Seq_LS180_Human0.89537014
139CMYC_18555785_Chip-Seq_ESCs_Mouse0.88702156

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86798872
2MP0003880_abnormal_central_pattern4.80618849
3MP0003635_abnormal_synaptic_transmissio3.97136864
4MP0008877_abnormal_DNA_methylation3.85069882
5MP0004270_analgesia3.75199805
6MP0009745_abnormal_behavioral_response3.27180762
7MP0008057_abnormal_DNA_replication3.25281928
8MP0002063_abnormal_learning/memory/cond3.09831412
9MP0001968_abnormal_touch/_nociception3.06414073
10MP0009046_muscle_twitch2.98092264
11MP0002064_seizures2.97954083
12MP0002572_abnormal_emotion/affect_behav2.74173333
13MP0002734_abnormal_mechanical_nocicepti2.73010135
14MP0005423_abnormal_somatic_nervous2.55815418
15MP0002272_abnormal_nervous_system2.47499397
16MP0001486_abnormal_startle_reflex2.44727090
17MP0001188_hyperpigmentation2.37733107
18MP0002736_abnormal_nociception_after2.34611987
19MP0002735_abnormal_chemical_nociception2.31126259
20MP0001501_abnormal_sleep_pattern2.26221406
21MP0002733_abnormal_thermal_nociception2.24244094
22MP0001970_abnormal_pain_threshold2.10500058
23MP0002067_abnormal_sensory_capabilities2.03184227
24MP0001440_abnormal_grooming_behavior2.01933313
25MP0006276_abnormal_autonomic_nervous1.93236471
26MP0002557_abnormal_social/conspecific_i1.86547268
27MP0002184_abnormal_innervation1.82081544
28MP0009780_abnormal_chondrocyte_physiolo1.82036661
29MP0000778_abnormal_nervous_system1.79706630
30MP0004858_abnormal_nervous_system1.78014797
31MP0008569_lethality_at_weaning1.69287915
32MP0002822_catalepsy1.67584924
33MP0002909_abnormal_adrenal_gland1.67082022
34MP0004924_abnormal_behavior1.65656843
35MP0005386_behavior/neurological_phenoty1.65656843
36MP0003787_abnormal_imprinting1.61460820
37MP0004811_abnormal_neuron_physiology1.60058817
38MP0008058_abnormal_DNA_repair1.55596854
39MP0003890_abnormal_embryonic-extraembry1.53718043
40MP0000566_synostosis1.53025220
41MP0003879_abnormal_hair_cell1.52996690
42MP0005409_darkened_coat_color1.52394186
43MP0000955_abnormal_spinal_cord1.51084912
44MP0005645_abnormal_hypothalamus_physiol1.49728796
45MP0006292_abnormal_olfactory_placode1.45096388
46MP0010094_abnormal_chromosome_stability1.42549688
47MP0000569_abnormal_digit_pigmentation1.39960601
48MP0005646_abnormal_pituitary_gland1.38769716
49MP0009672_abnormal_birth_weight1.36509833
50MP0002882_abnormal_neuron_morphology1.35868526
51MP0001293_anophthalmia1.35234030
52MP0010386_abnormal_urinary_bladder1.34876121
53MP0004142_abnormal_muscle_tone1.34036926
54MP0002066_abnormal_motor_capabilities/c1.32552878
55MP0003122_maternal_imprinting1.32069130
56MP0004885_abnormal_endolymph1.30683450
57MP0000015_abnormal_ear_pigmentation1.27532572
58MP0003329_amyloid_beta_deposits1.26915118
59MP0003633_abnormal_nervous_system1.19180441
60MP0003718_maternal_effect1.14816910
61MP0001502_abnormal_circadian_rhythm1.12900700
62MP0004145_abnormal_muscle_electrophysio1.12369804
63MP0003183_abnormal_peptide_metabolism1.12063428
64MP0001529_abnormal_vocalization1.11930705
65MP0004147_increased_porphyrin_level1.09350180
66MP0001984_abnormal_olfaction1.08476201
67MP0002152_abnormal_brain_morphology1.07823239
68MP0003172_abnormal_lysosome_physiology1.06789578
69MP0003283_abnormal_digestive_organ1.05492171
70MP0005174_abnormal_tail_pigmentation1.04555322
71MP0001905_abnormal_dopamine_level1.04087089
72MP0003567_abnormal_fetal_cardiomyocyte1.02094431
73MP0003111_abnormal_nucleus_morphology1.01721762
74MP0002638_abnormal_pupillary_reflex1.00932761
75MP0000631_abnormal_neuroendocrine_gland1.00867890
76MP0003631_nervous_system_phenotype0.99314700
77MP0004957_abnormal_blastocyst_morpholog0.96845618
78MP0009703_decreased_birth_body0.95981180
79MP0002229_neurodegeneration0.95159136
80MP0004742_abnormal_vestibular_system0.95156240
81MP0001986_abnormal_taste_sensitivity0.94472378
82MP0001963_abnormal_hearing_physiology0.93694580
83MP0005084_abnormal_gallbladder_morpholo0.91364064
84MP0002160_abnormal_reproductive_system0.91194398
85MP0002234_abnormal_pharynx_morphology0.91039286
86MP0003303_peritoneal_inflammation0.90300017
87MP0009697_abnormal_copulation0.88569248
88MP0004215_abnormal_myocardial_fiber0.88248820
89MP0001299_abnormal_eye_distance/0.87182889
90MP0009379_abnormal_foot_pigmentation0.84382735
91MP0003119_abnormal_digestive_system0.83449122
92MP0002396_abnormal_hematopoietic_system0.82373585
93MP0003634_abnormal_glial_cell0.81962786
94MP0002938_white_spotting0.81884281
95MP0001664_abnormal_digestion0.80753993
96MP0003632_abnormal_nervous_system0.80548864
97MP0002210_abnormal_sex_determination0.78666093
98MP0003698_abnormal_male_reproductive0.76468143
99MP0002069_abnormal_eating/drinking_beha0.76091314
100MP0001485_abnormal_pinna_reflex0.76086353
101MP0002876_abnormal_thyroid_physiology0.76001428
102MP0003136_yellow_coat_color0.75245081
103MP0008874_decreased_physiological_sensi0.74815985
104MP0004133_heterotaxia0.74769586
105MP0005394_taste/olfaction_phenotype0.74713950
106MP0005499_abnormal_olfactory_system0.74713950
107MP0003693_abnormal_embryo_hatching0.73830675
108MP0002752_abnormal_somatic_nervous0.73538639
109MP0003941_abnormal_skin_development0.72899964
110MP0001929_abnormal_gametogenesis0.72536775
111MP0002084_abnormal_developmental_patter0.70725620
112MP0002233_abnormal_nose_morphology0.70412964
113MP0004484_altered_response_of0.70293621
114MP0003123_paternal_imprinting0.70023697
115MP0000653_abnormal_sex_gland0.67972576
116MP0003121_genomic_imprinting0.67819367
117MP0005187_abnormal_penis_morphology0.67812104
118MP0003077_abnormal_cell_cycle0.67327833
119MP0001145_abnormal_male_reproductive0.67065247
120MP0003075_altered_response_to0.64731791
121MP0004085_abnormal_heartbeat0.64373829
122MP0004510_myositis0.63188239
123MP0005171_absent_coat_pigmentation0.60675665
124MP0001177_atelectasis0.60652315
125MP0002751_abnormal_autonomic_nervous0.60591079
126MP0005379_endocrine/exocrine_gland_phen0.59691587
127MP0000026_abnormal_inner_ear0.59691017
128MP0000681_abnormal_thyroid_gland0.59314341
129MP0000751_myopathy0.58704980
130MP0003861_abnormal_nervous_system0.58305503
131MP0006072_abnormal_retinal_apoptosis0.57053103
132MP0005535_abnormal_body_temperature0.56658747
133MP0000604_amyloidosis0.55254550
134MP0008872_abnormal_physiological_respon0.55132301
135MP0005551_abnormal_eye_electrophysiolog0.54127362

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.53283577
2Visual hallucinations (HP:0002367)5.40171704
3Myokymia (HP:0002411)5.34205061
4Focal seizures (HP:0007359)5.33992144
5Atonic seizures (HP:0010819)4.79850236
6Febrile seizures (HP:0002373)4.77282214
7Epileptic encephalopathy (HP:0200134)4.50739934
8Progressive cerebellar ataxia (HP:0002073)4.26819138
9Papilledema (HP:0001085)4.03563815
10Absence seizures (HP:0002121)4.01059942
11Dialeptic seizures (HP:0011146)3.74344871
12Action tremor (HP:0002345)3.72523454
13Generalized tonic-clonic seizures (HP:0002069)3.65319659
14Broad-based gait (HP:0002136)3.63722016
15Gaze-evoked nystagmus (HP:0000640)3.53015206
16Mutism (HP:0002300)3.50936076
17Supranuclear gaze palsy (HP:0000605)3.32273327
18Agitation (HP:0000713)3.12090415
19Volvulus (HP:0002580)2.97790709
20Genetic anticipation (HP:0003743)2.93465165
21Abnormality of binocular vision (HP:0011514)2.93156112
22Diplopia (HP:0000651)2.93156112
23Drooling (HP:0002307)2.89692047
24Excessive salivation (HP:0003781)2.89692047
25Abnormality of the labia minora (HP:0012880)2.88339115
26Poor eye contact (HP:0000817)2.87270858
27Abnormal eating behavior (HP:0100738)2.86699147
28Depression (HP:0000716)2.86576760
29Progressive inability to walk (HP:0002505)2.79741544
30Inappropriate behavior (HP:0000719)2.79542300
31Absent speech (HP:0001344)2.76381089
32Truncal ataxia (HP:0002078)2.74813528
33Urinary bladder sphincter dysfunction (HP:0002839)2.73305661
34Impaired smooth pursuit (HP:0007772)2.73208514
35Dysdiadochokinesis (HP:0002075)2.71396865
36Colon cancer (HP:0003003)2.70372965
37Hemiparesis (HP:0001269)2.65969617
38Hyperventilation (HP:0002883)2.64780384
39Anxiety (HP:0000739)2.63575044
40Dysmetria (HP:0001310)2.61952854
41Amblyopia (HP:0000646)2.61912419
42Stereotypic behavior (HP:0000733)2.51530763
43Obstructive sleep apnea (HP:0002870)2.50203002
44Impaired social interactions (HP:0000735)2.49878375
45Abnormal social behavior (HP:0012433)2.49878375
46Impaired vibration sensation in the lower limbs (HP:0002166)2.40080712
47Limb dystonia (HP:0002451)2.35143229
48Ankle clonus (HP:0011448)2.31576755
49Annular pancreas (HP:0001734)2.30902424
50Scanning speech (HP:0002168)2.27844528
51Cerebral inclusion bodies (HP:0100314)2.27280358
52Abnormality of ocular smooth pursuit (HP:0000617)2.24618300
53Cerebral hypomyelination (HP:0006808)2.23053928
54Amyotrophic lateral sclerosis (HP:0007354)2.22963673
55Postural instability (HP:0002172)2.22744052
56Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19133797
57Gonadotropin excess (HP:0000837)2.18837279
58Polyphagia (HP:0002591)2.18024037
59Neurofibrillary tangles (HP:0002185)2.17389755
60Apathy (HP:0000741)2.16871266
61Fetal akinesia sequence (HP:0001989)2.14558465
62Bradykinesia (HP:0002067)2.14299609
63Epileptiform EEG discharges (HP:0011182)2.14079647
64Inability to walk (HP:0002540)2.13679232
65Acute lymphatic leukemia (HP:0006721)2.12345612
66Horizontal nystagmus (HP:0000666)2.10744708
67Protruding tongue (HP:0010808)2.07232897
68Insidious onset (HP:0003587)2.06409815
69Termporal pattern (HP:0011008)2.06409815
70Neuronal loss in central nervous system (HP:0002529)2.06204697
71Hemiplegia (HP:0002301)2.05008224
72Generalized myoclonic seizures (HP:0002123)2.01899128
73Generalized hypopigmentation of hair (HP:0011358)2.01693089
74Abnormality of salivation (HP:0100755)2.01548376
75EEG with generalized epileptiform discharges (HP:0011198)2.00941019
76Abnormal lung lobation (HP:0002101)1.99715443
77Hypoglycemic seizures (HP:0002173)1.99579590
78Diminished motivation (HP:0000745)1.99545713
79Torticollis (HP:0000473)1.97316611
80Psychosis (HP:0000709)1.97298704
81Abnormality of the corticospinal tract (HP:0002492)1.95114849
82Hyperinsulinemic hypoglycemia (HP:0000825)1.94902465
83Morphological abnormality of the pyramidal tract (HP:0002062)1.93810812
84Gait imbalance (HP:0002141)1.92280468
85Impaired vibratory sensation (HP:0002495)1.92212470
86Unsteady gait (HP:0002317)1.91899323
87Neoplasm of the adrenal cortex (HP:0100641)1.90632668
88Akinesia (HP:0002304)1.88085871
89Abnormality of the lower motor neuron (HP:0002366)1.87892031
90Hypsarrhythmia (HP:0002521)1.87614064
91Muscular hypotonia of the trunk (HP:0008936)1.86579216
92Nonprogressive disorder (HP:0003680)1.85863731
93Tetraplegia (HP:0002445)1.85694719
94Iris hypopigmentation (HP:0007730)1.85009792
95Blue irides (HP:0000635)1.84866682
96Intestinal atresia (HP:0011100)1.84672231
97Nephroblastoma (Wilms tumor) (HP:0002667)1.83691632
98Aqueductal stenosis (HP:0002410)1.82792759
99Supernumerary spleens (HP:0009799)1.82403681
100Gait ataxia (HP:0002066)1.81619253
101Embryonal renal neoplasm (HP:0011794)1.81211213
102Sleep apnea (HP:0010535)1.80032729
103Macroglossia (HP:0000158)1.79635371
104Widely spaced teeth (HP:0000687)1.79169431
105CNS hypomyelination (HP:0003429)1.78276507
106Abnormality of calcium-phosphate metabolism (HP:0100530)1.78028105
107Restlessness (HP:0000711)1.77067140
108Lower limb muscle weakness (HP:0007340)1.76757431
109Choreoathetosis (HP:0001266)1.76389545
110Failure to thrive in infancy (HP:0001531)1.75552477
111Abnormality of chromosome stability (HP:0003220)1.75104611
112Neoplasm of the oral cavity (HP:0100649)1.74290529
113Spastic gait (HP:0002064)1.73875279
114Abnormality of chromosome segregation (HP:0002916)1.73016420
115Urethral obstruction (HP:0000796)1.72279575
116Ependymoma (HP:0002888)1.72098628
117Specific learning disability (HP:0001328)1.71599616
118Limb ataxia (HP:0002070)1.70468095
119Lower limb asymmetry (HP:0100559)1.69737321
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.69397633
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69397633
122Dyskinesia (HP:0100660)1.68767941
123Status epilepticus (HP:0002133)1.68430491
124Dyschromatopsia (HP:0007641)1.67749357
125Ulnar claw (HP:0001178)1.67549514
126Intention tremor (HP:0002080)1.66837103
127Abnormality of the astrocytes (HP:0100707)1.65014684
128Astrocytoma (HP:0009592)1.65014684
129Retinal dysplasia (HP:0007973)1.64128095
130Ocular albinism (HP:0001107)1.64103397
131Urinary urgency (HP:0000012)1.64090047
132Esotropia (HP:0000565)1.63043399
133Cortical visual impairment (HP:0100704)1.62999895
134Ventricular fibrillation (HP:0001663)1.62942647
135Chromsome breakage (HP:0040012)1.62255916
136Dysmetric saccades (HP:0000641)1.61973117
137Focal dystonia (HP:0004373)1.61897025
138Deeply set eye (HP:0000490)1.61764996
139Papillary thyroid carcinoma (HP:0002895)1.60594250
140Enlarged penis (HP:0000040)1.59770344
141Glioma (HP:0009733)1.59033572
142Abnormal hair whorl (HP:0010721)1.55994204
143Macroorchidism (HP:0000053)1.53012028
144Increased nuchal translucency (HP:0010880)1.52398215
145Generalized hypotonia (HP:0001290)1.50644316
146Paraplegia (HP:0010550)1.49790773
147Agnosia (HP:0010524)1.49529828
148Chronic hepatic failure (HP:0100626)1.49433800
149Spastic tetraparesis (HP:0001285)1.48394487
150Medulloblastoma (HP:0002885)1.47646311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.61255491
2MAP3K93.75070136
3EPHA43.63052542
4MARK13.19818784
5CASK2.96859089
6MAP2K72.89775502
7TNIK2.86837632
8MAP3K42.70314442
9MAP3K122.68115623
10RIPK42.61609059
11MINK12.56755981
12MKNK12.10486833
13TAF12.06462414
14CAMKK22.04261501
15CAMKK11.88050958
16KSR21.86084323
17PINK11.84724997
18FES1.83582511
19NTRK21.81659617
20NTRK11.81233056
21TRIM281.78143776
22MAP2K41.74953593
23CDC71.73253884
24NUAK11.70246612
25EIF2AK31.69196212
26PAK61.68276193
27PNCK1.67299370
28PLK31.66803292
29MUSK1.61645988
30DAPK21.56492341
31MAPK131.55495362
32GRK51.50269993
33PLK41.48971067
34PLK21.47866553
35PRKD31.47293328
36DAPK11.42728235
37CDK51.38328392
38STK381.36266353
39PRPF4B1.30514151
40TTK1.30387786
41ARAF1.30017680
42MAP3K21.28833433
43FRK1.25849367
44SIK21.23949638
45MAP4K21.23554563
46BMPR21.23136328
47KSR11.21700401
48FGFR21.21227921
49TSSK61.20645358
50BUB11.19287203
51CSNK1G11.18669818
52CDK191.17415303
53UHMK11.14034321
54MAP3K131.13010143
55STK38L1.11993740
56CDK31.09698203
57PRKCG1.07307589
58LATS21.06901378
59CSNK1G31.06139749
60WEE11.05831279
61CAMK2A1.05300982
62MAPKAPK51.04747748
63BRD41.03470221
64VRK21.02675474
65STK240.99471821
66CAMK10.98677977
67PASK0.98163668
68ZAK0.95764905
69STK30.95173359
70MAP3K60.91908367
71STK110.87537911
72SCYL20.87169558
73AKT30.81821650
74CAMK2B0.80971171
75MAP3K10.76584330
76PHKG10.76092122
77PHKG20.76092122
78MKNK20.75982956
79BRSK20.73830026
80VRK10.72761916
81EIF2AK20.72701784
82RAF10.71845726
83FGR0.71603403
84DYRK1A0.70783722
85CSNK1G20.69046673
86GRK70.69008142
87SRPK10.68395198
88CDK140.68036862
89SGK10.67485189
90PLK10.67336739
91SGK20.65877754
92CSNK1E0.65628321
93ALK0.65405146
94RPS6KA40.64769812
95DYRK30.63765587
96CDK180.63095053
97BRSK10.62924893
98CDK150.62551590
99RET0.61502009
100MOS0.61272189
101STK160.60723118
102PRKCE0.59640167
103TNK20.58103564
104ACVR1B0.57519702
105TIE10.56409211
106CDK11A0.55428608
107BMPR1B0.55417326
108CAMK2D0.55108789
109ATM0.54494703
110MARK20.53803444
111LMTK20.52836116
112CHEK20.52592332
113CSNK1D0.50193313
114CSNK1A1L0.49868592
115WNK30.49808626
116TAOK10.49314749
117FER0.49174314
118PRKCH0.48002959
119CAMK1G0.47686327
120HIPK20.46295809
121MAPK100.46237975
122ADRBK20.45233862
123SGK4940.44886802
124SGK2230.44886802
125NEK10.44621681
126MST40.44607579
127SGK30.43157968
128FYN0.43013959
129TYRO30.42840325
130PAK30.41763176
131PRKD20.41399229
132RPS6KA30.41078266
133BRAF0.40987363
134RPS6KA20.40403222
135OXSR10.37464764
136PDK10.37197282
137PRKG10.36486869
138NEK60.35703929
139PTK2B0.35167557
140WNK10.35012169
141CDC42BPA0.33485481
142TAOK30.31993500
143CAMK40.31688748
144PDPK10.30826110
145ADRBK10.28240390
146MATK0.27961143

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66738265
2Synaptic vesicle cycle_Homo sapiens_hsa047212.82162972
3Long-term potentiation_Homo sapiens_hsa047202.60517096
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57541213
5Glutamatergic synapse_Homo sapiens_hsa047242.46177854
6Circadian entrainment_Homo sapiens_hsa047132.42844780
7GABAergic synapse_Homo sapiens_hsa047272.39345411
8Olfactory transduction_Homo sapiens_hsa047402.37641051
9Morphine addiction_Homo sapiens_hsa050322.34058528
10Non-homologous end-joining_Homo sapiens_hsa034502.27354981
11Amphetamine addiction_Homo sapiens_hsa050312.22816883
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03932703
13Salivary secretion_Homo sapiens_hsa049702.03510769
14Taste transduction_Homo sapiens_hsa047422.01934263
15Dopaminergic synapse_Homo sapiens_hsa047282.01746128
16Insulin secretion_Homo sapiens_hsa049111.99277368
17Long-term depression_Homo sapiens_hsa047301.92666825
18Cholinergic synapse_Homo sapiens_hsa047251.83053030
19Serotonergic synapse_Homo sapiens_hsa047261.80371271
20Gastric acid secretion_Homo sapiens_hsa049711.70934064
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66725682
22Renin secretion_Homo sapiens_hsa049241.61028715
23Cocaine addiction_Homo sapiens_hsa050301.48553504
24Calcium signaling pathway_Homo sapiens_hsa040201.48079075
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47884540
26Propanoate metabolism_Homo sapiens_hsa006401.46218390
27Oxytocin signaling pathway_Homo sapiens_hsa049211.45658917
28GnRH signaling pathway_Homo sapiens_hsa049121.45242651
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42835867
30Collecting duct acid secretion_Homo sapiens_hsa049661.38671273
31RNA degradation_Homo sapiens_hsa030181.35088041
32Vitamin B6 metabolism_Homo sapiens_hsa007501.34823928
33Gap junction_Homo sapiens_hsa045401.32017149
34mRNA surveillance pathway_Homo sapiens_hsa030151.31104870
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26085717
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25219779
37Type II diabetes mellitus_Homo sapiens_hsa049301.23765019
38Mismatch repair_Homo sapiens_hsa034301.23667373
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22724548
40Protein export_Homo sapiens_hsa030601.21227361
41RNA transport_Homo sapiens_hsa030131.20376717
42cAMP signaling pathway_Homo sapiens_hsa040241.20178556
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17294408
44Selenocompound metabolism_Homo sapiens_hsa004501.14496265
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14028700
46Estrogen signaling pathway_Homo sapiens_hsa049151.13500319
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13089516
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.12838432
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09248272
50Melanogenesis_Homo sapiens_hsa049161.07970142
51Vibrio cholerae infection_Homo sapiens_hsa051101.07223933
52Base excision repair_Homo sapiens_hsa034101.05406686
53Basal transcription factors_Homo sapiens_hsa030221.04599086
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04358220
55Cell cycle_Homo sapiens_hsa041101.03172051
56Glioma_Homo sapiens_hsa052141.01414544
57Axon guidance_Homo sapiens_hsa043601.01078856
58Butanoate metabolism_Homo sapiens_hsa006500.97283202
59Pancreatic secretion_Homo sapiens_hsa049720.94806037
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94760695
61ErbB signaling pathway_Homo sapiens_hsa040120.92878071
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92748319
63DNA replication_Homo sapiens_hsa030300.92121465
64Oocyte meiosis_Homo sapiens_hsa041140.91931462
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91153577
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90596322
67One carbon pool by folate_Homo sapiens_hsa006700.88384847
68Folate biosynthesis_Homo sapiens_hsa007900.88007079
69Dorso-ventral axis formation_Homo sapiens_hsa043200.87815080
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87368932
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86279296
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.85914846
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.83254545
74Thyroid hormone synthesis_Homo sapiens_hsa049180.82209633
75Fanconi anemia pathway_Homo sapiens_hsa034600.81581220
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81160530
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.80655249
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80391670
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79977895
80Homologous recombination_Homo sapiens_hsa034400.77859546
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.76424106
82Choline metabolism in cancer_Homo sapiens_hsa052310.74698575
83Type I diabetes mellitus_Homo sapiens_hsa049400.73881439
84Phototransduction_Homo sapiens_hsa047440.72883564
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72682853
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72605833
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72045336
88Cardiac muscle contraction_Homo sapiens_hsa042600.71642365
89Purine metabolism_Homo sapiens_hsa002300.69738314
90MAPK signaling pathway_Homo sapiens_hsa040100.69290839
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.69266809
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62386142
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62325660
94Inositol phosphate metabolism_Homo sapiens_hsa005620.60580820
95VEGF signaling pathway_Homo sapiens_hsa043700.60567674
96Wnt signaling pathway_Homo sapiens_hsa043100.60289237
97Ras signaling pathway_Homo sapiens_hsa040140.59229336
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58071785
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57805132
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56167660
101Hippo signaling pathway_Homo sapiens_hsa043900.55516235
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55436326
103Dilated cardiomyopathy_Homo sapiens_hsa054140.53390078
104Rap1 signaling pathway_Homo sapiens_hsa040150.52589410
105Fatty acid elongation_Homo sapiens_hsa000620.51622960
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51309735
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51088319
108African trypanosomiasis_Homo sapiens_hsa051430.50788545
109Alcoholism_Homo sapiens_hsa050340.50455645
110Endometrial cancer_Homo sapiens_hsa052130.50053349
111Pyruvate metabolism_Homo sapiens_hsa006200.48546788
112Nucleotide excision repair_Homo sapiens_hsa034200.48487728
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48197561
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47553895
115Chemokine signaling pathway_Homo sapiens_hsa040620.47543060
116Tight junction_Homo sapiens_hsa045300.47323016
117Alzheimers disease_Homo sapiens_hsa050100.47238359
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46161900
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45568978
120Hedgehog signaling pathway_Homo sapiens_hsa043400.44800228
121RNA polymerase_Homo sapiens_hsa030200.43483885
122Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43002004
123mTOR signaling pathway_Homo sapiens_hsa041500.42837124
124Ovarian steroidogenesis_Homo sapiens_hsa049130.42765180
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42435238
126Colorectal cancer_Homo sapiens_hsa052100.42239108
127Glucagon signaling pathway_Homo sapiens_hsa049220.41009510
128Mineral absorption_Homo sapiens_hsa049780.40941148
129Endocytosis_Homo sapiens_hsa041440.40594841
130Spliceosome_Homo sapiens_hsa030400.40032366
131Salmonella infection_Homo sapiens_hsa051320.39830737
132Circadian rhythm_Homo sapiens_hsa047100.38956435
133Renal cell carcinoma_Homo sapiens_hsa052110.38596581
134Non-small cell lung cancer_Homo sapiens_hsa052230.37076987
135Platelet activation_Homo sapiens_hsa046110.36061001
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36007620
137Rheumatoid arthritis_Homo sapiens_hsa053230.35475918
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35211310
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34964037
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33666724
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31611615

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