B4GALT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the beta-1,4-galactosyltransferase (beta4GalT) family. Family members encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose. Each beta4GalT member has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus which then remains uncleaved to function as a transmembrane anchor. The enzyme encoded by this gene attaches the first galactose in the common carbohydrate-protein linkage (GlcA-beta1,3-Gal-beta1,3-Gal-beta1,4-Xyl-beta1-O-Ser) found in proteoglycans. This enzyme differs from other beta4GalTs because it lacks the conserved Cys residues found in beta4GalT1-beta4GalT6 and it is located in cis-Golgi instead of trans-Golgi. Mutations in this gene have been associated with the progeroid form of Ehlers-Danlos syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.24518330
2Golgi transport vesicle coating (GO:0048200)5.24518330
3protein retention in ER lumen (GO:0006621)5.20902969
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.94026413
5protein maturation by protein folding (GO:0022417)4.76845811
6negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.62062775
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.05327005
8GDP-mannose metabolic process (GO:0019673)3.99234629
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.90336480
10proline biosynthetic process (GO:0006561)3.89016528
11pinocytosis (GO:0006907)3.88750568
12DNA deamination (GO:0045006)3.87046034
13interferon-gamma production (GO:0032609)3.76369204
14sequestering of actin monomers (GO:0042989)3.70472360
15cellular response to interleukin-15 (GO:0071350)3.69591556
16superoxide anion generation (GO:0042554)3.66760209
17barbed-end actin filament capping (GO:0051016)3.62229116
18negative regulation of mast cell activation (GO:0033004)3.50364338
19neutrophil activation involved in immune response (GO:0002283)3.49328863
20pentose-phosphate shunt (GO:0006098)3.47612657
21positive regulation of mast cell activation (GO:0033005)3.43236010
22proteasome assembly (GO:0043248)3.41501104
23glycosphingolipid catabolic process (GO:0046479)3.38847699
24regulation of mammary gland epithelial cell proliferation (GO:0033599)3.37276317
25UV protection (GO:0009650)3.35938579
26negative regulation of erythrocyte differentiation (GO:0045647)3.33195328
27regulation of mast cell activation (GO:0033003)3.30050715
28neutrophil activation (GO:0042119)3.26756036
29regulation of mast cell degranulation (GO:0043304)3.21550339
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.20908636
31termination of RNA polymerase III transcription (GO:0006386)3.19469907
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.19469907
33glucose catabolic process (GO:0006007)3.18623021
34oligosaccharide catabolic process (GO:0009313)3.18107098
35ceramide catabolic process (GO:0046514)3.09533102
36protein localization to endosome (GO:0036010)3.09521238
37regulation of apoptotic process involved in morphogenesis (GO:1902337)3.08428545
38negative regulation of cell size (GO:0045792)3.06820585
39apoptotic process involved in morphogenesis (GO:0060561)3.06441546
40regulation of mast cell activation involved in immune response (GO:0033006)3.06029009
41stress fiber assembly (GO:0043149)3.04521573
42basement membrane organization (GO:0071711)3.03456633
43peptidyl-proline hydroxylation (GO:0019511)3.02286436
44endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.01059479
45positive regulation of mast cell degranulation (GO:0043306)3.00659519
46positive regulation of mast cell activation involved in immune response (GO:0033008)3.00659519
47glycolipid catabolic process (GO:0019377)3.00423943
48positive regulation of Cdc42 GTPase activity (GO:0043089)2.99667333
49NADPH regeneration (GO:0006740)2.99382444
50signal peptide processing (GO:0006465)2.98670976
51deoxyribonucleotide biosynthetic process (GO:0009263)2.98650307
52dendritic cell chemotaxis (GO:0002407)2.95427715
53mitotic nuclear envelope reassembly (GO:0007084)2.93146113
54nuclear envelope reassembly (GO:0031468)2.93146113
55hyaluronan catabolic process (GO:0030214)2.91873472
56skin morphogenesis (GO:0043589)2.90389292
57tRNA methylation (GO:0030488)2.90044413
58modulation by symbiont of host cellular process (GO:0044068)2.88586977
59regulation of B cell receptor signaling pathway (GO:0050855)2.86925510
60germinal center formation (GO:0002467)2.86090980
61pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84477455
62protein hydroxylation (GO:0018126)2.83544855
63mannose metabolic process (GO:0006013)2.82500127
64granulocyte activation (GO:0036230)2.79073251
65natural killer cell activation involved in immune response (GO:0002323)2.79061985
66pyrimidine-containing compound salvage (GO:0008655)2.79030466
67pyrimidine nucleoside salvage (GO:0043097)2.79030466
687-methylguanosine mRNA capping (GO:0006370)2.78311577
69positive regulation of protein homodimerization activity (GO:0090073)2.77869479
70deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.76822208
71positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76601411
72regulation of early endosome to late endosome transport (GO:2000641)2.74534794
73response to peptidoglycan (GO:0032494)2.73373654
747-methylguanosine RNA capping (GO:0009452)2.73260906
75RNA capping (GO:0036260)2.73260906
76mitochondrial fusion (GO:0008053)2.73256187
774-hydroxyproline metabolic process (GO:0019471)2.72774279
78activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72139172
79response to interleukin-15 (GO:0070672)2.70220629
80regulation of antigen processing and presentation (GO:0002577)2.70218448
81telomere maintenance via semi-conservative replication (GO:0032201)2.69410885
82modulation by virus of host process (GO:0019054)2.68493030
83NIK/NF-kappaB signaling (GO:0038061)2.68453124
84histone arginine methylation (GO:0034969)2.68338798
85peptidyl-arginine omega-N-methylation (GO:0035247)2.67160234
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65960259
87developmental pigmentation (GO:0048066)2.62586947
88cellular response to arsenic-containing substance (GO:0071243)2.61203011
89leukocyte aggregation (GO:0070486)2.61167719
90pentose metabolic process (GO:0019321)2.61013122
91atrioventricular valve morphogenesis (GO:0003181)2.60468023
92positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60212335
93dendritic cell migration (GO:0036336)2.58927854
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58738348
95opioid receptor signaling pathway (GO:0038003)2.58361070
96tRNA modification (GO:0006400)2.57921917
97protein heterotetramerization (GO:0051290)2.57917181
98amyloid precursor protein catabolic process (GO:0042987)2.57093728
99negative regulation of cell killing (GO:0031342)2.57088003
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.57088003
101positive regulation of nuclease activity (GO:0032075)2.57060973
102viral mRNA export from host cell nucleus (GO:0046784)2.56776459
103positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.56036674
104negative regulation of telomere maintenance (GO:0032205)2.55972289
105negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.55464378
106maternal placenta development (GO:0001893)2.55028046
107regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54515958
108telomere maintenance via recombination (GO:0000722)2.54127624
109rRNA modification (GO:0000154)2.53226490
110respiratory burst (GO:0045730)2.53100629
111response to laminar fluid shear stress (GO:0034616)2.52731001
112positive regulation of gamma-delta T cell activation (GO:0046645)2.51832234
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.51405698
114regulation of extracellular matrix disassembly (GO:0010715)2.51247697
115T cell migration (GO:0072678)2.50463304
116proline metabolic process (GO:0006560)2.50312553
117base-excision repair, AP site formation (GO:0006285)2.50201163
118DNA damage response, detection of DNA damage (GO:0042769)2.50196555
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.49310576
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.49310576
121modulation by symbiont of host immune response (GO:0052553)2.49310576
122positive regulation by symbiont of host defense response (GO:0052509)2.49310576
123modulation by symbiont of host defense response (GO:0052031)2.49310576
124modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.49310576
125deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49138370
126cell-substrate junction assembly (GO:0007044)2.48667977
127termination of RNA polymerase I transcription (GO:0006363)2.48465512
128positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48250459
129apoptotic cell clearance (GO:0043277)2.48008604
130cellular copper ion homeostasis (GO:0006878)2.47566123
131virion assembly (GO:0019068)2.45991007
132histamine secretion (GO:0001821)2.45770507
133adherens junction assembly (GO:0034333)2.45745697
134ribosomal small subunit biogenesis (GO:0042274)2.44926247
135signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.44910519
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.44910519
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.44910519
138activation of MAPKKK activity (GO:0000185)2.43826978
139antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.43203797
140hemidesmosome assembly (GO:0031581)2.42963204
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.41885413
142amino sugar catabolic process (GO:0046348)2.41521409
143pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.41254034
144endoplasmic reticulum unfolded protein response (GO:0030968)2.41112174
145type B pancreatic cell proliferation (GO:0044342)2.40267117
146regulation of double-strand break repair via homologous recombination (GO:0010569)2.40184730
147DNA strand renaturation (GO:0000733)2.40120234
148transcription from RNA polymerase I promoter (GO:0006360)2.39650399
149modulation by virus of host morphology or physiology (GO:0019048)2.39061834
150negative regulation of immunoglobulin mediated immune response (GO:0002890)2.38999311
151negative regulation of B cell mediated immunity (GO:0002713)2.38999311
152transcription-coupled nucleotide-excision repair (GO:0006283)2.38881291
153regulation of superoxide anion generation (GO:0032928)2.38855113
154maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.38315778
155maturation of 5.8S rRNA (GO:0000460)2.38299721
156peptidyl-histidine modification (GO:0018202)2.38273988
157RNA methylation (GO:0001510)2.38239843
158regulation of necrotic cell death (GO:0010939)2.36983152
159microtubule depolymerization (GO:0007019)2.36867273
160maintenance of protein localization in organelle (GO:0072595)2.34885274
161tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33593780
162RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33593780
163endodermal cell differentiation (GO:0035987)2.33468325
164sphingolipid catabolic process (GO:0030149)2.33186652
165regulation of myeloid leukocyte mediated immunity (GO:0002886)2.32505876
166DNA-dependent DNA replication (GO:0006261)2.32335556
167regulation of activation of Janus kinase activity (GO:0010533)2.32198267
168tRNA processing (GO:0008033)2.31950174
169embryo implantation (GO:0007566)2.31521078
170positive regulation of interleukin-1 beta secretion (GO:0050718)2.31485997
171focal adhesion assembly (GO:0048041)2.31174928
172cell-substrate adherens junction assembly (GO:0007045)2.31174928
173signal transduction involved in cell cycle checkpoint (GO:0072395)2.31151911
174DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.30187058
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.29869797
176replication fork processing (GO:0031297)2.29843827
177DNA catabolic process, exonucleolytic (GO:0000738)2.29693812
178kinetochore assembly (GO:0051382)2.29250471
179retrograde transport, endosome to Golgi (GO:0042147)2.28474370
180adhesion of symbiont to host (GO:0044406)2.23421360
181regulation of mitochondrial membrane potential (GO:0051881)2.22219607
182low-density lipoprotein particle clearance (GO:0034383)2.21809764
183regulation of nuclease activity (GO:0032069)2.21108356
184cellular response to unfolded protein (GO:0034620)2.19586853
185galactose catabolic process (GO:0019388)2.18681209
186negative regulation of DNA-templated transcription, elongation (GO:0032785)2.18652923
187lipopolysaccharide metabolic process (GO:0008653)2.17817272
188positive regulation of extracellular matrix organization (GO:1903055)2.17328678
189lipopolysaccharide biosynthetic process (GO:0009103)2.17258080
190angiogenesis involved in wound healing (GO:0060055)2.16878955
191heme biosynthetic process (GO:0006783)2.16254832
192ER-nucleus signaling pathway (GO:0006984)2.15823411
193regulation of cholesterol esterification (GO:0010872)2.15322397
194negative regulation of viral release from host cell (GO:1902187)2.15040022
195hypotonic response (GO:0006971)2.14127752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.64272412
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61745933
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.53317239
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.19624115
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.14411205
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.09687802
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06701412
8E2F7_22180533_ChIP-Seq_HELA_Human2.99960668
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89082001
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84480050
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.64936419
12VDR_21846776_ChIP-Seq_THP-1_Human2.63594834
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.57714091
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.55878013
15* LXR_22292898_ChIP-Seq_THP-1_Human2.55841403
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.55122136
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52645991
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47928862
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46680729
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43071235
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35597436
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.34452661
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33070589
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31140719
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31065385
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23400286
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18161487
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15132178
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13247295
30TP63_19390658_ChIP-ChIP_HaCaT_Human2.12097570
31PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10026403
32FLI1_27457419_Chip-Seq_LIVER_Mouse2.06626656
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.03042184
34* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00058157
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98127996
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.97775450
37VDR_23849224_ChIP-Seq_CD4+_Human1.97753584
38MYC_22102868_ChIP-Seq_BL_Human1.97355923
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.94275852
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.92724243
41ELK1_19687146_ChIP-ChIP_HELA_Human1.91649962
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83531877
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80730475
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80646386
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80045629
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77912589
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77248771
48* TET1_21451524_ChIP-Seq_MESCs_Mouse1.76883257
49ZNF263_19887448_ChIP-Seq_K562_Human1.76677870
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74135691
51FOXP3_21729870_ChIP-Seq_TREG_Human1.73035589
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72738344
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70684140
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.70014283
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.67273547
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61587462
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59457981
58* KDM2B_26808549_Chip-Seq_DND41_Human1.58124041
59P68_20966046_ChIP-Seq_HELA_Human1.53798186
60SPI1_23547873_ChIP-Seq_NB4_Human1.51599877
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.51117735
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.50148242
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49371164
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.48339495
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48143856
66EZH2_22144423_ChIP-Seq_EOC_Human1.47267739
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47218585
68UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46923801
69* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46764255
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46506236
71IRF1_19129219_ChIP-ChIP_H3396_Human1.46267771
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44535422
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43364569
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42035067
75TCF7_22412390_ChIP-Seq_EML_Mouse1.41858425
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40923630
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40795063
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40276576
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.40054323
80STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39611041
81VDR_24763502_ChIP-Seq_THP-1_Human1.38835065
82* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38161508
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37588172
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35355909
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.34267260
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34062101
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.33811945
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31730037
89LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31492700
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31235543
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.31059891
92BCL6_27268052_Chip-Seq_Bcells_Human1.30905133
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30830871
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30695736
95MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30536634
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29775766
97MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29642824
98BCOR_27268052_Chip-Seq_Bcells_Human1.29412914
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28268199
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28016290
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.27920244
102* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27053938
103XRN2_22483619_ChIP-Seq_HELA_Human1.27024955
104MAF_26560356_Chip-Seq_TH2_Human1.25884975
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25580229
106DCP1A_22483619_ChIP-Seq_HELA_Human1.23780226
107SMC4_20622854_ChIP-Seq_HELA_Human1.23330090
108* ATF3_27146783_Chip-Seq_COLON_Human1.23148305
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.22255163
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.21109996
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21100599
112MAF_26560356_Chip-Seq_TH1_Human1.20645155
113* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18977127
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18738007
115TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18735521
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18507575
117* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18084981
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17907277
119TP53_22127205_ChIP-Seq_IMR90_Human1.17735282
120KDM2B_26808549_Chip-Seq_K562_Human1.17541591
121EGR1_19374776_ChIP-ChIP_THP-1_Human1.17482169
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17284548
123TTF2_22483619_ChIP-Seq_HELA_Human1.17262358
124ELK1_22589737_ChIP-Seq_MCF10A_Human1.17033101
125* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16724747
126CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16647609
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15236114
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15151906
129CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14874219
130* RUNX1_22412390_ChIP-Seq_EML_Mouse1.14457224
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13616017
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13180214
133GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12483075
134CLOCK_20551151_ChIP-Seq_293T_Human1.12375476
135POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12280467
136UTX_26944678_Chip-Seq_JUKART_Human1.12174079
137RUNX1_27457419_Chip-Seq_LIVER_Mouse1.12053714
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11668393
139BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11440528
140NCOR1_26117541_ChIP-Seq_K562_Human1.11119520
141THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11071118
142* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10390634
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10209967
144P53_22387025_ChIP-Seq_ESCs_Mouse1.10139263
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10019984
146* GABP_19822575_ChIP-Seq_HepG2_Human1.09882929
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09868799
148E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09795434
149E2F1_18555785_Chip-Seq_ESCs_Mouse1.09426959
150ZFX_18555785_Chip-Seq_ESCs_Mouse1.09398786
151FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08916634
152CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08858208
153* CTCF_26484167_Chip-Seq_Bcells_Mouse1.08558132
154CTCF_21964334_Chip-Seq_Bcells_Human1.08072416
155NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08046812
156P300_18555785_Chip-Seq_ESCs_Mouse1.07242628
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06636806
158ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05857222
159CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05044212
160ESR2_21235772_ChIP-Seq_MCF-7_Human1.04750167
161PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02549140
162STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02428912
163SMAD1_18555785_Chip-Seq_ESCs_Mouse1.02401338
164MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02265561
165* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02137821
166NANOG_18555785_Chip-Seq_ESCs_Mouse1.01867067
167PU1_27457419_Chip-Seq_LIVER_Mouse1.01232192
168ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01038175
169* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00620985
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99795738
171CREB1_26743006_Chip-Seq_LNCaP_Human0.99602819
172* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99158601
173KLF4_18555785_Chip-Seq_ESCs_Mouse0.99068223
174* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98854049
175SOX2_18555785_Chip-Seq_ESCs_Mouse0.98143479
176* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97149784
177CIITA_25753668_ChIP-Seq_RAJI_Human0.96468386
178LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94963901
179RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94843836
180OCT4_18555785_Chip-Seq_ESCs_Mouse0.94371711
181CMYC_18555785_Chip-Seq_ESCs_Mouse0.94316638
182CRX_20693478_ChIP-Seq_RETINA_Mouse0.94125725
183CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93087024
184TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91631091
185ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91257474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.95232967
2MP0008438_abnormal_cutaneous_collagen3.90245361
3MP0003705_abnormal_hypodermis_morpholog3.76600646
4MP0005451_abnormal_body_composition3.65663402
5MP0009840_abnormal_foam_cell3.24801168
6MP0001188_hyperpigmentation3.07241925
7MP0000015_abnormal_ear_pigmentation2.98388303
8MP0001835_abnormal_antigen_presentation2.83430827
9MP0003191_abnormal_cellular_cholesterol2.74297798
10MP0005671_abnormal_response_to2.71733420
11MP0009785_altered_susceptibility_to2.30672388
12MP0002148_abnormal_hypersensitivity_rea2.28644802
13MP0004858_abnormal_nervous_system2.25420440
14MP0005171_absent_coat_pigmentation2.23603435
15MP0003566_abnormal_cell_adhesion2.21174308
16MP0004272_abnormal_basement_membrane2.19601945
17MP0001849_ear_inflammation2.17865656
18MP0003941_abnormal_skin_development2.17527446
19MP0005174_abnormal_tail_pigmentation2.16990234
20MP0002877_abnormal_melanocyte_morpholog2.14955373
21MP0008058_abnormal_DNA_repair2.12441890
22MP0003763_abnormal_thymus_physiology2.10392582
23MP0001790_abnormal_immune_system2.07906188
24MP0005387_immune_system_phenotype2.07906188
25MP0005000_abnormal_immune_tolerance2.07032665
26MP0006292_abnormal_olfactory_placode2.05709826
27MP0002419_abnormal_innate_immunity2.03868542
28MP0002132_abnormal_respiratory_system1.99362539
29MP0000566_synostosis1.88341716
30MP0002452_abnormal_antigen_presenting1.87756311
31MP0003436_decreased_susceptibility_to1.87181310
32MP0004381_abnormal_hair_follicle1.86470400
33MP0002420_abnormal_adaptive_immunity1.85680872
34MP0001819_abnormal_immune_cell1.84804832
35MP0005409_darkened_coat_color1.79515404
36MP0005025_abnormal_response_to1.77258340
37MP0002723_abnormal_immune_serum1.75862463
38MP0000858_altered_metastatic_potential1.75080077
39MP0001800_abnormal_humoral_immune1.74831781
40MP0005623_abnormal_meninges_morphology1.74318653
41MP0002277_abnormal_respiratory_mucosa1.72369210
42MP0001986_abnormal_taste_sensitivity1.71629260
43MP0000372_irregular_coat_pigmentation1.66482868
44MP0006276_abnormal_autonomic_nervous1.66057127
45MP0009333_abnormal_splenocyte_physiolog1.63592513
46MP0003693_abnormal_embryo_hatching1.61870907
47MP0010386_abnormal_urinary_bladder1.61451486
48MP0003786_premature_aging1.60587577
49MP0010030_abnormal_orbit_morphology1.59425533
50MP0003724_increased_susceptibility_to1.59293176
51MP0004510_myositis1.58959582
52MP0001853_heart_inflammation1.56595198
53MP0004233_abnormal_muscle_weight1.54318773
54MP0005257_abnormal_intraocular_pressure1.51357719
55MP0002405_respiratory_system_inflammati1.49732411
56MP0009278_abnormal_bone_marrow1.48388994
57MP0005670_abnormal_white_adipose1.46916283
58MP0003453_abnormal_keratinocyte_physiol1.46440535
59MP0009384_cardiac_valve_regurgitation1.45581235
60MP0003111_abnormal_nucleus_morphology1.45172206
61MP0005084_abnormal_gallbladder_morpholo1.45000169
62MP0000003_abnormal_adipose_tissue1.43409243
63MP0003091_abnormal_cell_migration1.42617412
64MP0005023_abnormal_wound_healing1.42535191
65MP0005075_abnormal_melanosome_morpholog1.40939770
66MP0008007_abnormal_cellular_replicative1.40697066
67MP0006082_CNS_inflammation1.38702040
68MP0002398_abnormal_bone_marrow1.38358897
69MP0003303_peritoneal_inflammation1.36809659
70MP0000751_myopathy1.35239937
71MP0003183_abnormal_peptide_metabolism1.34115925
72MP0000716_abnormal_immune_system1.33536891
73MP0003806_abnormal_nucleotide_metabolis1.32928744
74MP0003448_altered_tumor_morphology1.32591526
75MP0004947_skin_inflammation1.31540479
76MP0002933_joint_inflammation1.31405249
77MP0003787_abnormal_imprinting1.31378186
78MP0005379_endocrine/exocrine_gland_phen1.29972854
79MP0005501_abnormal_skin_physiology1.29965932
80MP0001958_emphysema1.29895424
81MP0001542_abnormal_bone_strength1.26467632
82MP0009764_decreased_sensitivity_to1.25985928
83MP0000750_abnormal_muscle_regeneration1.25491901
84MP0005076_abnormal_cell_differentiation1.25454820
85MP0000689_abnormal_spleen_morphology1.24699329
86MP0002095_abnormal_skin_pigmentation1.24513218
87MP0002060_abnormal_skin_morphology1.22660582
88MP0008995_early_reproductive_senescence1.22358650
89MP0005375_adipose_tissue_phenotype1.22012751
90MP0002638_abnormal_pupillary_reflex1.21732511
91MP0002163_abnormal_gland_morphology1.21502902
92MP0005083_abnormal_biliary_tract1.20880562
93MP0005645_abnormal_hypothalamus_physiol1.20061164
94MP0010094_abnormal_chromosome_stability1.19884417
95MP0004185_abnormal_adipocyte_glucose1.19807033
96MP0002722_abnormal_immune_system1.17014008
97MP0003136_yellow_coat_color1.15414378
98MP0001186_pigmentation_phenotype1.14940842
99MP0005666_abnormal_adipose_tissue1.12498364
100MP0000343_altered_response_to1.11954477
101MP0002102_abnormal_ear_morphology1.11866389
102MP0000685_abnormal_immune_system1.11766155
103MP0003186_abnormal_redox_activity1.11721822
104MP0005503_abnormal_tendon_morphology1.11510850
105MP0002160_abnormal_reproductive_system1.11079151
106MP0000703_abnormal_thymus_morphology1.10785357
107MP0008004_abnormal_stomach_pH1.10259505
108MP0002876_abnormal_thyroid_physiology1.09240954
109MP0005275_abnormal_skin_tensile1.08560476
110MP0000681_abnormal_thyroid_gland1.07257308
111MP0002429_abnormal_blood_cell1.05422597
112MP0003300_gastrointestinal_ulcer1.05292483
113MP0000733_abnormal_muscle_development1.05227927
114MP0002396_abnormal_hematopoietic_system1.04925421
115MP0001533_abnormal_skeleton_physiology1.04916553
116MP0000767_abnormal_smooth_muscle1.04767840
117MP0008260_abnormal_autophagy1.01522198
118MP0005397_hematopoietic_system_phenotyp1.01288490
119MP0001545_abnormal_hematopoietic_system1.01288490
120MP0001845_abnormal_inflammatory_respons1.01154494
121MP0003075_altered_response_to1.00805358
122MP0000604_amyloidosis1.00213511
123MP0003329_amyloid_beta_deposits0.99666956
124MP0003828_pulmonary_edema0.99164464
125MP0003880_abnormal_central_pattern0.98460040
126MP0005464_abnormal_platelet_physiology0.97979667
127MP0001243_abnormal_dermal_layer0.97848269
128MP0003315_abnormal_perineum_morphology0.97344937
129MP0005330_cardiomyopathy0.97333557
130MP0000013_abnormal_adipose_tissue0.97063244
131MP0005390_skeleton_phenotype0.96527857
132MP0002796_impaired_skin_barrier0.96225435
133MP0004782_abnormal_surfactant_physiolog0.94985814
134MP0002751_abnormal_autonomic_nervous0.94865128
135MP0009697_abnormal_copulation0.94364649
136MP0005310_abnormal_salivary_gland0.94265427
137MP0000465_gastrointestinal_hemorrhage0.94115508
138MP0000049_abnormal_middle_ear0.92149539
139MP0005621_abnormal_cell_physiology0.91647800
140MP0002089_abnormal_postnatal_growth/wei0.91329125
141MP0008057_abnormal_DNA_replication0.90569216
142MP0002998_abnormal_bone_remodeling0.90041815
143MP0001529_abnormal_vocalization0.89836820
144MP0005389_reproductive_system_phenotype0.89075764
145MP0000490_abnormal_crypts_of0.88597644
146MP0006054_spinal_hemorrhage0.87939199
147MP0003279_aneurysm0.87316567
148MP0003172_abnormal_lysosome_physiology0.86291004
149MP0009931_abnormal_skin_appearance0.85945750
150MP0001919_abnormal_reproductive_system0.85805348
151MP0000613_abnormal_salivary_gland0.85573382
152MP0010368_abnormal_lymphatic_system0.85024124
153MP0004142_abnormal_muscle_tone0.84771697
154MP0002075_abnormal_coat/hair_pigmentati0.84352257
155MP0001915_intracranial_hemorrhage0.84037067
156MP0001216_abnormal_epidermal_layer0.83684572
157MP0002254_reproductive_system_inflammat0.82449857
158MP0000759_abnormal_skeletal_muscle0.82067846
159MP0000678_abnormal_parathyroid_gland0.81944988
160MP0000358_abnormal_cell_content/0.81527359
161MP0001119_abnormal_female_reproductive0.80655937
162MP0004133_heterotaxia0.80631055
163MP0003718_maternal_effect0.80232502
164MP0005508_abnormal_skeleton_morphology0.79518741
165MP0002295_abnormal_pulmonary_circulatio0.77345406
166MP0005165_increased_susceptibility_to0.77261673
167MP0005360_urolithiasis0.76716787
168MP0001730_embryonic_growth_arrest0.75499051
169MP0001661_extended_life_span0.75259648
170MP0005384_cellular_phenotype0.74692423
171MP0000747_muscle_weakness0.74412978
172MP0008469_abnormal_protein_level0.74242402
173MP0000467_abnormal_esophagus_morphology0.72702216
174MP0009053_abnormal_anal_canal0.72684846
175MP0000537_abnormal_urethra_morphology0.71950320
176MP0002249_abnormal_larynx_morphology0.68625385

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.10681909
2Premature rupture of membranes (HP:0001788)4.70470377
3Chromsome breakage (HP:0040012)4.43791769
4Protrusio acetabuli (HP:0003179)4.07141047
5Vertebral compression fractures (HP:0002953)4.01955258
6Recurrent abscess formation (HP:0002722)3.52471020
7Abnormality of the renal collecting system (HP:0004742)3.47963628
8Duplicated collecting system (HP:0000081)3.40211211
9Type 2 muscle fiber atrophy (HP:0003554)3.01817098
10Dysostosis multiplex (HP:0000943)2.98926577
11Retrobulbar optic neuritis (HP:0100654)2.98040999
12Optic neuritis (HP:0100653)2.98040999
13Achilles tendon contracture (HP:0001771)2.97231049
14Cervical subluxation (HP:0003308)2.95942325
15Meckel diverticulum (HP:0002245)2.83438743
16Abnormality of the preputium (HP:0100587)2.77675109
17Mediastinal lymphadenopathy (HP:0100721)2.76837109
18Recurrent cutaneous fungal infections (HP:0011370)2.76819403
19Chronic mucocutaneous candidiasis (HP:0002728)2.76819403
20Abnormality of the ileum (HP:0001549)2.73775884
21Congenital stationary night blindness (HP:0007642)2.72930565
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.72548181
23Severe combined immunodeficiency (HP:0004430)2.71928325
24Short nail (HP:0001799)2.70054280
25Abnormality of the Achilles tendon (HP:0005109)2.68785422
26Ragged-red muscle fibers (HP:0003200)2.68728596
27Distal upper limb amyotrophy (HP:0007149)2.68162194
28Upper limb amyotrophy (HP:0009129)2.68162194
29Distal lower limb muscle weakness (HP:0009053)2.66545203
30Ankle contracture (HP:0006466)2.66110307
31Clubbing of toes (HP:0100760)2.64640568
32Chronic obstructive pulmonary disease (HP:0006510)2.62657763
33Obstructive lung disease (HP:0006536)2.62657763
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.62239966
35Vacuolated lymphocytes (HP:0001922)2.61870983
36Axonal loss (HP:0003447)2.59781431
37Fragile skin (HP:0001030)2.58450422
38Abnormal hair whorl (HP:0010721)2.53884395
39Hyperacusis (HP:0010780)2.53070774
40Type I transferrin isoform profile (HP:0003642)2.50326816
413-Methylglutaconic aciduria (HP:0003535)2.48284545
42Stomatitis (HP:0010280)2.48050224
43* Atrophic scars (HP:0001075)2.47610919
44Muscle fiber atrophy (HP:0100295)2.45464711
45Meningitis (HP:0001287)2.45218529
46Recurrent bacterial skin infections (HP:0005406)2.45075757
47Agammaglobulinemia (HP:0004432)2.43828782
48Microvesicular hepatic steatosis (HP:0001414)2.42186434
49Distal lower limb amyotrophy (HP:0008944)2.41869873
50Increased IgM level (HP:0003496)2.41213258
51Blue sclerae (HP:0000592)2.40968837
52Panhypogammaglobulinemia (HP:0003139)2.40566580
53True hermaphroditism (HP:0010459)2.40560576
54Cerebral aneurysm (HP:0004944)2.37627236
55Abnormality of dentin (HP:0010299)2.36878682
56Prostate neoplasm (HP:0100787)2.36772614
57Joint stiffness (HP:0001387)2.35124888
58Elbow flexion contracture (HP:0002987)2.33866708
59Eczematoid dermatitis (HP:0000976)2.32726187
60Biconcave vertebral bodies (HP:0004586)2.32275921
61Abnormality of DNA repair (HP:0003254)2.31767657
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.31387134
63Premature skin wrinkling (HP:0100678)2.31219762
64Broad distal phalanx of finger (HP:0009836)2.31177518
65Abnormality of polysaccharide metabolism (HP:0011012)2.30445731
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.30445731
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.30445731
68Orchitis (HP:0100796)2.30004330
69Myositis (HP:0100614)2.29908539
70Granulocytopenia (HP:0001913)2.29258507
71Reticulocytopenia (HP:0001896)2.28753244
72Recurrent fungal infections (HP:0002841)2.28677169
73Encephalitis (HP:0002383)2.27435116
74Abnormality of macrophages (HP:0004311)2.27004013
75Urinary glycosaminoglycan excretion (HP:0003541)2.26310442
76Mucopolysacchariduria (HP:0008155)2.26310442
77Abnormality of eosinophils (HP:0001879)2.25248953
78Abnormality of the distal phalanges of the toes (HP:0010182)2.23383819
79Ulnar bowing (HP:0003031)2.22348461
80Hypertensive crisis (HP:0100735)2.21656254
81IgM deficiency (HP:0002850)2.20538714
82Increased cerebral lipofuscin (HP:0011813)2.20452537
83Stridor (HP:0010307)2.19685008
84Spinal rigidity (HP:0003306)2.19463201
85Cheilitis (HP:0100825)2.16472739
86Thyroiditis (HP:0100646)2.15605572
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15314747
88Upper limb muscle weakness (HP:0003484)2.14991681
89Bone marrow hypocellularity (HP:0005528)2.14945079
90Abnormality of chromosome stability (HP:0003220)2.14599540
91Hand muscle atrophy (HP:0009130)2.11739126
92Flattened epiphyses (HP:0003071)2.11663393
93Generalized amyotrophy (HP:0003700)2.11306362
94J-shaped sella turcica (HP:0002680)2.11152445
95Increased serum ferritin (HP:0003281)2.10972998
96Genu recurvatum (HP:0002816)2.08993934
97Hemorrhage of the eye (HP:0011885)2.07903380
98Abnormality of the prostate (HP:0008775)2.07462057
99Birth length less than 3rd percentile (HP:0003561)2.07216759
100Abnormality of liposaccharide metabolism (HP:0010968)2.07125378
101Abnormality of glycosphingolipid metabolism (HP:0004343)2.07125378
102Abnormality of glycolipid metabolism (HP:0010969)2.07125378
103Increased connective tissue (HP:0009025)2.06516473
104Loss of speech (HP:0002371)2.06259229
105Bladder diverticulum (HP:0000015)2.05709788
106Chronic diarrhea (HP:0002028)2.04744299
107Progressive external ophthalmoplegia (HP:0000590)2.04423869
108Entropion (HP:0000621)2.04041164
109Recurrent pneumonia (HP:0006532)2.03537732
110Combined immunodeficiency (HP:0005387)2.02867773
111Abnormality of T cell number (HP:0011839)2.01739075
112Mildly elevated creatine phosphokinase (HP:0008180)2.01284405
113Thin bony cortex (HP:0002753)2.00474159
114Fatigue (HP:0012378)2.00170770
115Trismus (HP:0000211)1.98122898
116Pancreatic cysts (HP:0001737)1.98120802
117Myocardial infarction (HP:0001658)1.96997705
118Recurrent skin infections (HP:0001581)1.96082862
119Eosinophilia (HP:0001880)1.95871281
120Mitral regurgitation (HP:0001653)1.94786428
121Elevated erythrocyte sedimentation rate (HP:0003565)1.94093080
122Abnormality of the thoracic spine (HP:0100711)1.93854783
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93234843
124Rough bone trabeculation (HP:0100670)1.92294628
125Septo-optic dysplasia (HP:0100842)1.92123015
126IgG deficiency (HP:0004315)1.91706500
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.91499431
128Nuclear cataract (HP:0100018)1.91140639
129Long palpebral fissure (HP:0000637)1.90940778
130Cellulitis (HP:0100658)1.90803957
131Disproportionate tall stature (HP:0001519)1.90217992
132Interstitial pulmonary disease (HP:0006530)1.89364495
133Increased variability in muscle fiber diameter (HP:0003557)1.89000948
134Increased neuronal autofluorescent lipopigment (HP:0002074)1.88899331
135T lymphocytopenia (HP:0005403)1.88493510
136Upper motor neuron abnormality (HP:0002127)1.88378647
137Wormian bones (HP:0002645)1.87702004
138Keratoconjunctivitis sicca (HP:0001097)1.87540303
139Abnormality of the acetabulum (HP:0003170)1.86606680
140Testicular atrophy (HP:0000029)1.86335411
141Thoracic kyphosis (HP:0002942)1.85138727
142Reduced subcutaneous adipose tissue (HP:0003758)1.82884735
143Natal tooth (HP:0000695)1.82234774
144Broad face (HP:0000283)1.81354885
145Pancreatic fibrosis (HP:0100732)1.81196639
146Dilatation of the ascending aorta (HP:0005111)1.80113036
147Flat capital femoral epiphysis (HP:0003370)1.80000536
148Hypothermia (HP:0002045)1.79985721
149Purpura (HP:0000979)1.79685521
150Ectopic kidney (HP:0000086)1.79229141
151Prolonged neonatal jaundice (HP:0006579)1.78284564
152Leukocytosis (HP:0001974)1.77695778
153Petechiae (HP:0000967)1.76897491
154Glomerulopathy (HP:0100820)1.75514861
155Systemic lupus erythematosus (HP:0002725)1.75490636
156Flat acetabular roof (HP:0003180)1.75206763
157Abnormality of skeletal muscle fiber size (HP:0012084)1.74413541
158Difficulty climbing stairs (HP:0003551)1.74353460
159Recurrent lower respiratory tract infections (HP:0002783)1.74094135
160Hepatosplenomegaly (HP:0001433)1.73054590
161Triphalangeal thumb (HP:0001199)1.73030552
162Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72820567
163Abnormal protein N-linked glycosylation (HP:0012347)1.72820567
164Abnormal protein glycosylation (HP:0012346)1.72820567
165Abnormal glycosylation (HP:0012345)1.72820567
166Deep venous thrombosis (HP:0002625)1.72625817
167Congenital glaucoma (HP:0001087)1.72492007
168Reduced antithrombin III activity (HP:0001976)1.72364640
169Abnormality of incisor morphology (HP:0011063)1.72288832
170Preaxial hand polydactyly (HP:0001177)1.71853513
171Progressive muscle weakness (HP:0003323)1.71172741
172Neoplasm of the adrenal cortex (HP:0100641)1.70700265
173Atelectasis (HP:0100750)1.69857586
174Aortic dissection (HP:0002647)1.69690065
175Abnormality of carpal bone ossification (HP:0006257)1.69335974
176Polygenic inheritance (HP:0010982)1.69247087
177Abnormality of the carotid arteries (HP:0005344)1.68746751
178Keratoconjunctivitis (HP:0001096)1.67285237
179Myopathic facies (HP:0002058)1.66456570
180Abnormality of T cells (HP:0002843)1.66279587
181Hypoplasia of the fovea (HP:0007750)1.65705329
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.65705329
183Pancytopenia (HP:0001876)1.65647968
184Amyloidosis (HP:0011034)1.65502651
185Recurrent viral infections (HP:0004429)1.65347339
186Pulmonary infiltrates (HP:0002113)1.65171269
187Optic nerve coloboma (HP:0000588)1.65083728
188* Joint laxity (HP:0001388)1.64585070
189Venous abnormality (HP:0002624)1.64077156
190Abnormality of the tricuspid valve (HP:0001702)1.63958303
191Bulbar palsy (HP:0001283)1.63168484
192Breast hypoplasia (HP:0003187)1.63008176
193Abnormality of the umbilical cord (HP:0010881)1.62504375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.20727003
2TRIB33.98680857
3IRAK43.70504352
4ZAK3.33624252
5STK163.20499435
6TXK3.08525136
7ERN13.02512598
8MAP3K142.71924609
9CASK2.53110499
10SIK32.49172354
11SIK12.47224936
12SMG12.43106781
13PLK42.38505380
14MAP2K32.18822913
15BUB12.18297131
16ARAF1.96888040
17MARK11.83490002
18BLK1.81319309
19IRAK11.72932330
20IRAK21.65045046
21TTN1.64549868
22ADRBK21.64287379
23ICK1.60778575
24TAOK21.60690577
25BCKDK1.57009296
26YES11.52627078
27SRPK11.52601650
28PKN21.51218687
29RIPK11.51161888
30GRK11.50571559
31EPHB11.50465091
32EIF2AK21.49164871
33PIM21.48360537
34NME21.46800700
35PAK41.44710054
36TNIK1.42866332
37CLK11.39714416
38BMPR1B1.39520877
39ABL21.36974940
40PRPF4B1.35321037
41MAP3K31.34995121
42TEC1.32714854
43LIMK11.32559579
44IKBKE1.28997231
45MKNK21.25587378
46PRKD21.23010934
47PDGFRA1.22008365
48DDR21.20246695
49LMTK21.18041780
50VRK11.17641775
51MAP4K11.14685678
52IKBKB1.14073975
53EPHB21.10915121
54TLK11.08724772
55PTK21.06260493
56BMPR21.05311254
57MST1R1.04532254
58GRK71.02546413
59EIF2AK31.01176933
60MKNK11.00874807
61VRK21.00593672
62ERBB31.00110402
63DYRK20.99964741
64NLK0.98497687
65TAOK10.98231791
66AKT30.96380237
67NEK60.96352408
68MAP3K10.96095779
69INSRR0.93956817
70MAP2K70.90255547
71KDR0.89830288
72BCR0.89020393
73RPS6KA20.88675176
74PBK0.88259578
75EEF2K0.87231161
76MARK20.84204456
77MAPK130.78873207
78JAK30.78824782
79PLK30.77663429
80SYK0.77540242
81LRRK20.76852747
82FGFR40.76229708
83LYN0.75381129
84PIM10.75355282
85EPHA20.74853143
86PDPK10.74248268
87KIT0.74199993
88MAPK110.74194012
89BRD40.74056464
90PTK60.73211024
91TYK20.73174247
92MTOR0.73006916
93TGFBR20.72926461
94TNK20.72603492
95ITK0.72262109
96NTRK10.72085509
97ATR0.71689551
98TBK10.71465875
99MAP3K60.70452452
100ILK0.69541045
101ZAP700.69180423
102PRKCI0.68550589
103CDK30.68395515
104BMX0.68071288
105MAP3K80.67516142
106PLK20.65275888
107MAP2K20.64862233
108MAP3K120.63019030
109PASK0.62415076
110BTK0.61981246
111CDK120.61648195
112CDK80.60427394
113EIF2AK10.59673743
114MAPKAPK30.59632571
115DAPK30.59371145
116PRKD30.59117087
117STK380.58866169
118MOS0.58826406
119LCK0.58739364
120CDC42BPA0.58648367
121RPS6KL10.58491634
122RPS6KC10.58491634
123MARK30.58228042
124PLK10.57536407
125AURKA0.57482090
126MAPK120.57056447
127STK40.56686644
128PRKG20.55982919
129TSSK60.55495908
130SCYL20.54859004
131NUAK10.53906792
132CHUK0.53692924
133STK100.51827569
134CDK90.51314872
135CDK40.51055471
136STK240.50865758
137HCK0.49255202
138GRK60.48432023
139MAP3K110.46747066
140MET0.46407613
141MAPK70.46365185
142MYLK0.45368893
143BRAF0.44637819
144PDK20.44255448
145NEK90.43942142
146PRKCD0.43532222
147CDK70.42937326
148TESK10.42855558
149STK38L0.42834658
150TTK0.42427823
151EPHA30.41840650
152KSR20.41787027
153MAP3K100.41691160
154CHEK20.41299728
155PAK20.40973411
156NME10.40853077
157TRPM70.40268779
158MAP3K130.40197079
159ACVR1B0.39896199
160MAP2K40.39853637
161PRKCE0.39486516
162PAK10.39467996
163RIPK40.37284723
164HIPK20.36916869
165SGK20.36793470
166TESK20.36379087
167MST40.34485987
168RPS6KA60.34245896
169DYRK1B0.34178234

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.95732937
2RNA polymerase_Homo sapiens_hsa030202.75085429
3Proteasome_Homo sapiens_hsa030502.72792423
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52365997
5Fanconi anemia pathway_Homo sapiens_hsa034602.52087665
6Primary immunodeficiency_Homo sapiens_hsa053402.35012639
7Galactose metabolism_Homo sapiens_hsa000522.20770544
8Protein export_Homo sapiens_hsa030602.20158015
9DNA replication_Homo sapiens_hsa030302.15742163
10Fructose and mannose metabolism_Homo sapiens_hsa000512.08502308
11Mismatch repair_Homo sapiens_hsa034302.08491863
12Homologous recombination_Homo sapiens_hsa034402.07659569
13Pentose phosphate pathway_Homo sapiens_hsa000302.04991618
14Graft-versus-host disease_Homo sapiens_hsa053322.04532948
15Base excision repair_Homo sapiens_hsa034102.01438633
16Other glycan degradation_Homo sapiens_hsa005111.88739123
17Bladder cancer_Homo sapiens_hsa052191.88371733
18Acute myeloid leukemia_Homo sapiens_hsa052211.87299830
19Pyrimidine metabolism_Homo sapiens_hsa002401.81131161
20Allograft rejection_Homo sapiens_hsa053301.75614306
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68468406
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67720068
23Nucleotide excision repair_Homo sapiens_hsa034201.61644017
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.60159409
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58216652
26Biosynthesis of amino acids_Homo sapiens_hsa012301.57279636
27Ribosome_Homo sapiens_hsa030101.55284389
28Non-homologous end-joining_Homo sapiens_hsa034501.51355549
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51252308
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.48711769
31Chronic myeloid leukemia_Homo sapiens_hsa052201.45410267
32Phototransduction_Homo sapiens_hsa047441.43273775
33Basal transcription factors_Homo sapiens_hsa030221.42313641
34Spliceosome_Homo sapiens_hsa030401.41827640
35Autoimmune thyroid disease_Homo sapiens_hsa053201.41703136
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.40461978
37Measles_Homo sapiens_hsa051621.37805275
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.37012341
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36188256
40Prion diseases_Homo sapiens_hsa050201.34789478
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33383351
42Hematopoietic cell lineage_Homo sapiens_hsa046401.31969204
43Rheumatoid arthritis_Homo sapiens_hsa053231.27668535
44Sphingolipid metabolism_Homo sapiens_hsa006001.24644683
45Oxidative phosphorylation_Homo sapiens_hsa001901.24544415
46Purine metabolism_Homo sapiens_hsa002301.24322305
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23960040
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23009550
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20157467
50p53 signaling pathway_Homo sapiens_hsa041151.19961579
51Notch signaling pathway_Homo sapiens_hsa043301.19902802
52Pancreatic cancer_Homo sapiens_hsa052121.18633580
53VEGF signaling pathway_Homo sapiens_hsa043701.17670853
54Carbon metabolism_Homo sapiens_hsa012001.14883434
55Phagosome_Homo sapiens_hsa041451.11809748
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09860627
57Antigen processing and presentation_Homo sapiens_hsa046121.07223172
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07064567
59Non-small cell lung cancer_Homo sapiens_hsa052231.06547953
60Asthma_Homo sapiens_hsa053101.05645959
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.04923564
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04072815
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03880685
64Fatty acid elongation_Homo sapiens_hsa000621.03319178
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.03275861
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02580358
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00312600
68Leishmaniasis_Homo sapiens_hsa051401.00032962
69* Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99126246
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98558277
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97785365
72Amoebiasis_Homo sapiens_hsa051460.96824935
73* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96246325
74Epstein-Barr virus infection_Homo sapiens_hsa051690.94283993
75Lysosome_Homo sapiens_hsa041420.94142793
76Hepatitis C_Homo sapiens_hsa051600.92460117
77Malaria_Homo sapiens_hsa051440.91743206
78Toxoplasmosis_Homo sapiens_hsa051450.91695051
79Focal adhesion_Homo sapiens_hsa045100.91303250
80Small cell lung cancer_Homo sapiens_hsa052220.91059542
81Arachidonic acid metabolism_Homo sapiens_hsa005900.90762117
82Endocytosis_Homo sapiens_hsa041440.89867869
83Type I diabetes mellitus_Homo sapiens_hsa049400.89177945
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88008056
85ECM-receptor interaction_Homo sapiens_hsa045120.87016936
86Glutathione metabolism_Homo sapiens_hsa004800.86757917
87Collecting duct acid secretion_Homo sapiens_hsa049660.86589651
88Huntingtons disease_Homo sapiens_hsa050160.86187209
89Thyroid cancer_Homo sapiens_hsa052160.85805828
90RNA degradation_Homo sapiens_hsa030180.84677882
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84204615
92Regulation of autophagy_Homo sapiens_hsa041400.83462056
93Parkinsons disease_Homo sapiens_hsa050120.83204550
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81930446
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80184555
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.78710573
97T cell receptor signaling pathway_Homo sapiens_hsa046600.75055252
98Shigellosis_Homo sapiens_hsa051310.74638251
99Herpes simplex infection_Homo sapiens_hsa051680.74340569
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73839097
101Nicotine addiction_Homo sapiens_hsa050330.73618841
102Proteoglycans in cancer_Homo sapiens_hsa052050.73456990
103Vibrio cholerae infection_Homo sapiens_hsa051100.73340944
104Apoptosis_Homo sapiens_hsa042100.73167807
105One carbon pool by folate_Homo sapiens_hsa006700.69695285
106Tuberculosis_Homo sapiens_hsa051520.68476784
107Osteoclast differentiation_Homo sapiens_hsa043800.65831950
108Influenza A_Homo sapiens_hsa051640.65305501
109Cell cycle_Homo sapiens_hsa041100.64739773
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.62134986
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61797926
112Insulin signaling pathway_Homo sapiens_hsa049100.61172618
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.60757492
114Phenylalanine metabolism_Homo sapiens_hsa003600.60494176
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60323943
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60292848
117Pertussis_Homo sapiens_hsa051330.59459940
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59012065
119Alzheimers disease_Homo sapiens_hsa050100.55966625
120Steroid biosynthesis_Homo sapiens_hsa001000.55869516
121Legionellosis_Homo sapiens_hsa051340.54308108
122Renal cell carcinoma_Homo sapiens_hsa052110.53697712
123Chemokine signaling pathway_Homo sapiens_hsa040620.53312837
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52105194
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.51960338
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51695574
127Folate biosynthesis_Homo sapiens_hsa007900.51155192
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50296767
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49973775
130Viral myocarditis_Homo sapiens_hsa054160.49958790
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49468926
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49324478
133HIF-1 signaling pathway_Homo sapiens_hsa040660.48954806
134mTOR signaling pathway_Homo sapiens_hsa041500.48485376
135Serotonergic synapse_Homo sapiens_hsa047260.47895277
136RNA transport_Homo sapiens_hsa030130.47528610
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.46839328
138Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45688621
139Arginine and proline metabolism_Homo sapiens_hsa003300.44248032
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42331348
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.42311659
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41382226
143Glioma_Homo sapiens_hsa052140.41328249
144Sulfur metabolism_Homo sapiens_hsa009200.41254015
145N-Glycan biosynthesis_Homo sapiens_hsa005100.41119189
146Salmonella infection_Homo sapiens_hsa051320.40216577
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39286164
148Hepatitis B_Homo sapiens_hsa051610.38911998
149HTLV-I infection_Homo sapiens_hsa051660.37292620
150TNF signaling pathway_Homo sapiens_hsa046680.34846309
151Morphine addiction_Homo sapiens_hsa050320.33755087
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33349691
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33006366
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32991177
155mRNA surveillance pathway_Homo sapiens_hsa030150.31263227
156B cell receptor signaling pathway_Homo sapiens_hsa046620.29804294
157Viral carcinogenesis_Homo sapiens_hsa052030.28760097
158Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27006743

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »