B9D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a B9 domain-containing protein, one of several that are involved in ciliogenesis. Alterations in expression of this gene have been found in a family with Meckel syndrome. Meckel syndrome has been associated with at least six different genes. This gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)4.70550630
2epithelial cilium movement (GO:0003351)4.57198851
3axonemal dynein complex assembly (GO:0070286)4.49540578
4cullin deneddylation (GO:0010388)4.43803832
5protein deneddylation (GO:0000338)4.37563819
6intraciliary transport (GO:0042073)4.13476145
7GTP biosynthetic process (GO:0006183)4.07390696
8left/right pattern formation (GO:0060972)4.05044219
9regulation of mitochondrial translation (GO:0070129)3.91647024
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.82465925
11respiratory electron transport chain (GO:0022904)3.80918625
12electron transport chain (GO:0022900)3.77581848
13cilium or flagellum-dependent cell motility (GO:0001539)3.71995139
14UTP biosynthetic process (GO:0006228)3.67019204
15axoneme assembly (GO:0035082)3.65382803
16mitochondrial respiratory chain complex assembly (GO:0033108)3.54352077
17guanosine-containing compound biosynthetic process (GO:1901070)3.53119468
18nucleoside diphosphate phosphorylation (GO:0006165)3.43830516
19establishment of integrated proviral latency (GO:0075713)3.43809733
20motile cilium assembly (GO:0044458)3.43197236
21regulation of cilium movement (GO:0003352)3.36565197
22chaperone-mediated protein transport (GO:0072321)3.33325361
23respiratory chain complex IV assembly (GO:0008535)3.32391274
24piRNA metabolic process (GO:0034587)3.29746246
25male meiosis (GO:0007140)3.26632694
26protein polyglutamylation (GO:0018095)3.26480068
27centriole assembly (GO:0098534)3.20670517
28centriole replication (GO:0007099)3.20419586
29microtubule depolymerization (GO:0007019)3.20329235
307-methylguanosine mRNA capping (GO:0006370)3.14473321
31aldehyde catabolic process (GO:0046185)3.10649228
32mitotic metaphase plate congression (GO:0007080)3.08780569
33microtubule severing (GO:0051013)3.06672899
34cytochrome complex assembly (GO:0017004)3.06086831
35RNA capping (GO:0036260)3.05045550
367-methylguanosine RNA capping (GO:0009452)3.05045550
37* cilium assembly (GO:0042384)3.04865289
38UTP metabolic process (GO:0046051)3.03815269
39* cilium organization (GO:0044782)3.03762934
40purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02579235
41protein neddylation (GO:0045116)2.95126657
42protein targeting to mitochondrion (GO:0006626)2.88907779
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86878744
44water-soluble vitamin biosynthetic process (GO:0042364)2.85859103
45L-serine metabolic process (GO:0006563)2.85516508
46kinetochore assembly (GO:0051382)2.84744254
47nucleoside triphosphate biosynthetic process (GO:0009142)2.83223650
48ribosomal small subunit assembly (GO:0000028)2.79855283
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.79158199
50regulation of meiosis I (GO:0060631)2.78967741
51ribonucleoside triphosphate biosynthetic process (GO:0009201)2.77889836
52establishment of protein localization to mitochondrion (GO:0072655)2.76933175
53* cilium morphogenesis (GO:0060271)2.75549657
54ATP biosynthetic process (GO:0006754)2.75190024
55CTP metabolic process (GO:0046036)2.74869184
56CTP biosynthetic process (GO:0006241)2.74869184
57protein complex localization (GO:0031503)2.72732362
58establishment of viral latency (GO:0019043)2.72679264
59energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72223682
60ATP synthesis coupled proton transport (GO:0015986)2.72223682
61protein maturation by protein folding (GO:0022417)2.71691900
62protein localization to mitochondrion (GO:0070585)2.70362656
63oxidative phosphorylation (GO:0006119)2.70197851
64pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.68405105
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67228001
66establishment of protein localization to mitochondrial membrane (GO:0090151)2.66837126
67pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.66430241
68inner mitochondrial membrane organization (GO:0007007)2.66030644
69cotranslational protein targeting to membrane (GO:0006613)2.65422146
70regulation of centriole replication (GO:0046599)2.63684447
71microtubule bundle formation (GO:0001578)2.62324175
72metaphase plate congression (GO:0051310)2.61911729
73transcription elongation from RNA polymerase II promoter (GO:0006368)2.61889665
74binding of sperm to zona pellucida (GO:0007339)2.61794419
75proteasome assembly (GO:0043248)2.61393621
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.61313663
77termination of RNA polymerase III transcription (GO:0006386)2.61313663
78protein targeting to ER (GO:0045047)2.60483807
79synaptonemal complex organization (GO:0070193)2.57451340
80nonmotile primary cilium assembly (GO:0035058)2.57231258
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56841728
82sequestering of actin monomers (GO:0042989)2.56576222
83protein localization to cilium (GO:0061512)2.56146561
84mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55258252
85spermatid development (GO:0007286)2.55040054
86viral transcription (GO:0019083)2.54515192
87negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.54504116
88negative regulation of ligase activity (GO:0051352)2.54504116
89pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.54098191
90acrosome reaction (GO:0007340)2.53749344
91regulation of meiosis (GO:0040020)2.52922843
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.52059695
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51560799
94sperm motility (GO:0030317)2.51211398
95mitochondrial respiratory chain complex I assembly (GO:0032981)2.51199360
96NADH dehydrogenase complex assembly (GO:0010257)2.51199360
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51199360
98protein-cofactor linkage (GO:0018065)2.51122982
99left/right axis specification (GO:0070986)2.50897396
100translational termination (GO:0006415)2.50808427
101DNA replication-dependent nucleosome assembly (GO:0006335)2.50413037
102DNA replication-dependent nucleosome organization (GO:0034723)2.50413037
103spliceosomal complex assembly (GO:0000245)2.50283962
104base-excision repair, AP site formation (GO:0006285)2.50122029
105sperm-egg recognition (GO:0035036)2.49338388
106regulation of cellular amino acid metabolic process (GO:0006521)2.49237930
107protein localization to endoplasmic reticulum (GO:0070972)2.48804891
108pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.48296398
109chromatin remodeling at centromere (GO:0031055)2.47847266
110attachment of spindle microtubules to kinetochore (GO:0008608)2.47160752
111meiotic cell cycle (GO:0051321)2.46899974
112kinetochore organization (GO:0051383)2.46546974
113single strand break repair (GO:0000012)2.45042756
114peptidyl-histidine modification (GO:0018202)2.44843093
115histone exchange (GO:0043486)2.44809895
116deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.44267757
117establishment of chromosome localization (GO:0051303)2.43113558
118protein complex biogenesis (GO:0070271)2.42786086
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42536168
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42536168
121ventricular system development (GO:0021591)2.42313099
122hydrogen ion transmembrane transport (GO:1902600)2.41768289
123intracellular protein transmembrane import (GO:0044743)2.40496335
124CENP-A containing nucleosome assembly (GO:0034080)2.39478647
125transcription-coupled nucleotide-excision repair (GO:0006283)2.39173651
126spliceosomal snRNP assembly (GO:0000387)2.38730477
127ribosomal small subunit biogenesis (GO:0042274)2.38555881
128microtubule polymerization or depolymerization (GO:0031109)2.38386075
129glutathione derivative biosynthetic process (GO:1901687)2.37929204
130glutathione derivative metabolic process (GO:1901685)2.37929204
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.37723567
132protein K6-linked ubiquitination (GO:0085020)2.37422753
133DNA replication checkpoint (GO:0000076)2.37342858
134translation (GO:0006412)2.37098100
135synaptonemal complex assembly (GO:0007130)2.36676773
136rRNA modification (GO:0000154)2.33934930
137pyrimidine nucleotide catabolic process (GO:0006244)2.33808427
138negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.32442693
139notochord development (GO:0030903)2.31056509
140DNA methylation involved in gamete generation (GO:0043046)2.30501880
141* cellular component assembly involved in morphogenesis (GO:0010927)2.30480535
142male meiosis I (GO:0007141)2.29637925
143negative regulation of meiosis (GO:0045835)2.28754132
144histone H2A acetylation (GO:0043968)2.27056108
145negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.26717168
146histone arginine methylation (GO:0034969)2.26025430
147DNA-templated transcription, elongation (GO:0006354)2.24343817
148negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.22676331
149purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.22366447
150regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.21658951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.51729201
2EZH2_22144423_ChIP-Seq_EOC_Human3.30779757
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26110422
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.91525653
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.65750809
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.62512527
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46942588
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42998455
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10195742
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09487804
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.09477293
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07529212
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.04136328
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02144691
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01583801
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.99443442
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95455145
18VDR_22108803_ChIP-Seq_LS180_Human1.89325025
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80632164
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.79701886
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73567830
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72821483
23FUS_26573619_Chip-Seq_HEK293_Human1.69406642
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.67760460
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66185204
26DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61526104
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57723585
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57592400
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55130881
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54588981
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.53164470
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52843736
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50070260
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44694701
35GBX2_23144817_ChIP-Seq_PC3_Human1.43467257
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42613700
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42152212
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40409452
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39396463
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38205883
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37903686
42POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37341201
43RNF2_27304074_Chip-Seq_NSC_Mouse1.36492074
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34316381
45* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34003550
46TTF2_22483619_ChIP-Seq_HELA_Human1.31851570
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30481640
48DCP1A_22483619_ChIP-Seq_HELA_Human1.29206654
49* VDR_23849224_ChIP-Seq_CD4+_Human1.27320929
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26043208
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24587581
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.24103300
53* GABP_19822575_ChIP-Seq_HepG2_Human1.23874877
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.23644904
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.22948871
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.20954262
57XRN2_22483619_ChIP-Seq_HELA_Human1.20355047
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19249874
59E2F7_22180533_ChIP-Seq_HELA_Human1.18581710
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17587520
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15861481
62KDM5A_27292631_Chip-Seq_BREAST_Human1.15522851
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15435787
64* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14162111
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.13605498
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12198280
67CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10263823
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09282895
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08609502
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08235426
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.07798469
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.07766913
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07452431
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.06483562
75ELK1_19687146_ChIP-ChIP_HELA_Human1.05827650
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03836562
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.03058140
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03023297
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.01689413
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01153719
81REST_21632747_ChIP-Seq_MESCs_Mouse1.00608684
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99919763
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99646499
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98965008
85CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98611490
86KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98522817
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96002787
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96001030
89E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95119477
90MYC_18940864_ChIP-ChIP_HL60_Human0.94835249
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94598722
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94395425
93REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93945997
94NANOG_21062744_ChIP-ChIP_HESCs_Human0.93753955
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93664758
96E2F1_21310950_ChIP-Seq_MCF-7_Human0.93372154
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93027059
98FOXP3_21729870_ChIP-Seq_TREG_Human0.92773434
99ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89811565
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89650913
101TAF15_26573619_Chip-Seq_HEK293_Human0.87054526
102AR_21909140_ChIP-Seq_LNCAP_Human0.86060748
103ELK1_22589737_ChIP-Seq_MCF10A_Human0.85944832
104KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85776933
105CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85713635
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85505305
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.85166710
108SALL1_21062744_ChIP-ChIP_HESCs_Human0.84965755
109ZNF274_21170338_ChIP-Seq_K562_Hela0.84340849
110TP53_22573176_ChIP-Seq_HFKS_Human0.83547112
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83296338
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82858430
113EWS_26573619_Chip-Seq_HEK293_Human0.82843961
114NANOG_16153702_ChIP-ChIP_HESCs_Human0.82552552
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81676327
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.81519732
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80975776
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.80520659
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80172093
120SOX9_26525672_Chip-Seq_HEART_Mouse0.79979368
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78362933
122* EOMES_21245162_ChIP-Seq_HESCs_Human0.77081003
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76901981
124IRF1_19129219_ChIP-ChIP_H3396_Human0.76034556
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73296044
126E2F1_17053090_ChIP-ChIP_MCF-7_Human0.72408422
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.70511376

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.53827915
2MP0006292_abnormal_olfactory_placode2.50621638
3MP0005410_abnormal_fertilization2.38702519
4MP0008877_abnormal_DNA_methylation2.38513184
5MP0004133_heterotaxia2.20971020
6MP0001529_abnormal_vocalization2.14093211
7MP0003693_abnormal_embryo_hatching2.13668366
8MP0009379_abnormal_foot_pigmentation2.11097992
9MP0003123_paternal_imprinting2.07953267
10MP0003880_abnormal_central_pattern2.05705061
11MP0003122_maternal_imprinting1.98211566
12MP0002102_abnormal_ear_morphology1.95860925
13MP0003121_genomic_imprinting1.90748593
14MP0008875_abnormal_xenobiotic_pharmacok1.87913109
15MP0003136_yellow_coat_color1.85044536
16MP0004270_analgesia1.82573968
17MP0006072_abnormal_retinal_apoptosis1.78451876
18MP0004957_abnormal_blastocyst_morpholog1.78268509
19MP0010030_abnormal_orbit_morphology1.74693477
20MP0001984_abnormal_olfaction1.74283744
21MP0008789_abnormal_olfactory_epithelium1.66149327
22MP0008932_abnormal_embryonic_tissue1.65619858
23MP0005646_abnormal_pituitary_gland1.64188141
24MP0003718_maternal_effect1.60499755
25MP0001929_abnormal_gametogenesis1.59025313
26MP0003186_abnormal_redox_activity1.58532237
27MP0003315_abnormal_perineum_morphology1.54638232
28MP0002638_abnormal_pupillary_reflex1.53335953
29MP0003698_abnormal_male_reproductive1.52522662
30MP0006276_abnormal_autonomic_nervous1.51409073
31MP0002160_abnormal_reproductive_system1.51337425
32MP0003786_premature_aging1.48330818
33MP0010386_abnormal_urinary_bladder1.45756084
34MP0005394_taste/olfaction_phenotype1.45333357
35MP0005499_abnormal_olfactory_system1.45333357
36MP0000631_abnormal_neuroendocrine_gland1.43561564
37MP0000678_abnormal_parathyroid_gland1.42960687
38MP0002210_abnormal_sex_determination1.41978519
39MP0003111_abnormal_nucleus_morphology1.41927074
40MP0000778_abnormal_nervous_system1.41352415
41MP0003283_abnormal_digestive_organ1.38533060
42MP0000049_abnormal_middle_ear1.37546058
43MP0003787_abnormal_imprinting1.35916493
44MP0003890_abnormal_embryonic-extraembry1.34761531
45MP0003937_abnormal_limbs/digits/tail_de1.32864990
46MP0002837_dystrophic_cardiac_calcinosis1.32661174
47MP0002734_abnormal_mechanical_nocicepti1.31969922
48MP0005623_abnormal_meninges_morphology1.30894772
49MP0003119_abnormal_digestive_system1.30417433
50MP0003077_abnormal_cell_cycle1.30151650
51MP0010094_abnormal_chromosome_stability1.29365724
52MP0008058_abnormal_DNA_repair1.28941967
53MP0009780_abnormal_chondrocyte_physiolo1.28644221
54MP0003942_abnormal_urinary_system1.27489001
55MP0002249_abnormal_larynx_morphology1.23193438
56MP0003646_muscle_fatigue1.22558092
57MP0005423_abnormal_somatic_nervous1.21257108
58MP0001905_abnormal_dopamine_level1.19772158
59MP0002938_white_spotting1.18792413
60MP0006036_abnormal_mitochondrial_physio1.18737482
61MP0002736_abnormal_nociception_after1.17958428
62MP0000566_synostosis1.16772319
63MP0000653_abnormal_sex_gland1.16768364
64MP0002090_abnormal_vision1.16509517
65MP0002132_abnormal_respiratory_system1.14351583
66MP0005379_endocrine/exocrine_gland_phen1.13890120
67MP0001145_abnormal_male_reproductive1.13713613
68MP0001485_abnormal_pinna_reflex1.13502040
69MP0003861_abnormal_nervous_system1.12455732
70MP0004019_abnormal_vitamin_homeostasis1.12121057
71MP0003806_abnormal_nucleotide_metabolis1.12120949
72MP0001188_hyperpigmentation1.10150546
73MP0002163_abnormal_gland_morphology1.09900544
74MP0002233_abnormal_nose_morphology1.07633728
75MP0008995_early_reproductive_senescence1.06375599
76MP0002234_abnormal_pharynx_morphology1.05776345
77MP0002282_abnormal_trachea_morphology1.05210963
78MP0005389_reproductive_system_phenotype1.04498133
79MP0002909_abnormal_adrenal_gland1.03832176
80MP0002184_abnormal_innervation1.03759354
81MP0002751_abnormal_autonomic_nervous1.02753270
82MP0003011_delayed_dark_adaptation1.02496039
83MP0006035_abnormal_mitochondrial_morpho1.01764780
84MP0005408_hypopigmentation1.01501596
85MP0002161_abnormal_fertility/fecundity1.00635129
86MP0008007_abnormal_cellular_replicative1.00382815
87MP0005248_abnormal_Harderian_gland1.00318929
88MP0002572_abnormal_emotion/affect_behav0.99963798
89MP0002557_abnormal_social/conspecific_i0.98246583
90MP0002085_abnormal_embryonic_tissue0.98063844
91MP0003755_abnormal_palate_morphology0.96161494
92MP0001968_abnormal_touch/_nociception0.96119665
93MP0009250_abnormal_appendicular_skeleto0.95502545
94MP0000026_abnormal_inner_ear0.94487524
95MP0003635_abnormal_synaptic_transmissio0.94457232
96MP0001299_abnormal_eye_distance/0.94456098
97MP0002697_abnormal_eye_size0.93723710
98MP0003878_abnormal_ear_physiology0.93723374
99MP0005377_hearing/vestibular/ear_phenot0.93723374
100MP0002084_abnormal_developmental_patter0.92597032
101MP0001346_abnormal_lacrimal_gland0.92097421
102MP0002116_abnormal_craniofacial_bone0.91687617
103MP0003938_abnormal_ear_development0.91601954
104MP0002822_catalepsy0.91550317
105MP0000534_abnormal_ureter_morphology0.90031019
106MP0000358_abnormal_cell_content/0.89392358
107MP0005391_vision/eye_phenotype0.89167288
108MP0001324_abnormal_eye_pigmentation0.88507690
109MP0002752_abnormal_somatic_nervous0.88094258
110MP0008057_abnormal_DNA_replication0.87686833
111MP0002152_abnormal_brain_morphology0.87515323
112MP0002272_abnormal_nervous_system0.85976988
113MP0005551_abnormal_eye_electrophysiolog0.85773553
114MP0005645_abnormal_hypothalamus_physiol0.85753862
115MP0000372_irregular_coat_pigmentation0.85559068
116MP0001440_abnormal_grooming_behavior0.84752573
117MP0001764_abnormal_homeostasis0.84747585
118MP0001293_anophthalmia0.84503751
119MP0005084_abnormal_gallbladder_morpholo0.84485006
120MP0002063_abnormal_learning/memory/cond0.84236457
121MP0009046_muscle_twitch0.83072019
122MP0004233_abnormal_muscle_weight0.82914898
123MP0001286_abnormal_eye_development0.80985501
124MP0002067_abnormal_sensory_capabilities0.80523623
125MP0004145_abnormal_muscle_electrophysio0.80024053
126MP0005187_abnormal_penis_morphology0.79464393
127MP0001944_abnormal_pancreas_morphology0.79437460
128MP0005332_abnormal_amino_acid0.78722360
129MP0003115_abnormal_respiratory_system0.78646439
130MP0005253_abnormal_eye_physiology0.78449881
131MP0003941_abnormal_skin_development0.78207598

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.37602372
2Abnormal respiratory motile cilium physiology (HP:0012261)5.24036372
3Abnormal ciliary motility (HP:0012262)4.93891006
4Rhinitis (HP:0012384)4.46735736
5Abnormal respiratory epithelium morphology (HP:0012253)4.38704391
6Abnormal respiratory motile cilium morphology (HP:0005938)4.38704391
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.88508634
8Absent/shortened dynein arms (HP:0200106)3.88508634
9Medial flaring of the eyebrow (HP:0010747)3.74272029
10Molar tooth sign on MRI (HP:0002419)3.62351837
11Abnormality of midbrain morphology (HP:0002418)3.62351837
12Chronic bronchitis (HP:0004469)3.54623013
13Congenital primary aphakia (HP:0007707)3.51983382
14Gait imbalance (HP:0002141)3.49897494
15Nephronophthisis (HP:0000090)3.49766890
16* Pancreatic fibrosis (HP:0100732)3.37861617
17Nephrogenic diabetes insipidus (HP:0009806)3.20334572
18Acute necrotizing encephalopathy (HP:0006965)3.16940313
19Genital tract atresia (HP:0001827)2.99469211
20Vaginal atresia (HP:0000148)2.97495069
21* True hermaphroditism (HP:0010459)2.96467755
22Bifid tongue (HP:0010297)2.92837575
23Increased hepatocellular lipid droplets (HP:0006565)2.91093433
24Facial cleft (HP:0002006)2.87822982
25* Pancreatic cysts (HP:0001737)2.87491127
26Hepatocellular necrosis (HP:0001404)2.84531145
27Abnormal mitochondria in muscle tissue (HP:0008316)2.80097196
28Supernumerary spleens (HP:0009799)2.79605384
29Lipid accumulation in hepatocytes (HP:0006561)2.74885857
30Poor coordination (HP:0002370)2.70699893
31Hepatic necrosis (HP:0002605)2.64839332
32Abnormality of the renal medulla (HP:0100957)2.58202434
33Cerebral edema (HP:0002181)2.55909815
34Progressive macrocephaly (HP:0004481)2.54465064
35Renal Fanconi syndrome (HP:0001994)2.51186059
36Infertility (HP:0000789)2.41479443
37Median cleft lip (HP:0000161)2.41186731
38Aplasia/Hypoplasia of the lens (HP:0008063)2.39286431
39Nasal polyposis (HP:0100582)2.35497228
40Hyperglycinemia (HP:0002154)2.35306253
41Acute encephalopathy (HP:0006846)2.33904317
42Abnormal number of erythroid precursors (HP:0012131)2.30146959
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29785517
44Abnormality of dentin (HP:0010299)2.28903183
45* Preaxial hand polydactyly (HP:0001177)2.26534575
46Abnormality of the labia minora (HP:0012880)2.26283457
47Patellar aplasia (HP:0006443)2.23442978
48Congenital malformation of the right heart (HP:0011723)2.23294764
49Double outlet right ventricle (HP:0001719)2.23294764
50Aplasia/Hypoplasia of the patella (HP:0006498)2.12416513
51* Postaxial hand polydactyly (HP:0001162)2.12047935
52Abnormality of cells of the erythroid lineage (HP:0012130)2.11703100
53Mitochondrial inheritance (HP:0001427)2.11344433
54Broad foot (HP:0001769)2.08952222
55Respiratory failure (HP:0002878)2.07992335
56Increased intramyocellular lipid droplets (HP:0012240)2.07868790
57Breast hypoplasia (HP:0003187)2.06420609
58Bronchiectasis (HP:0002110)2.06183841
59* Aplasia/Hypoplasia of the tongue (HP:0010295)2.02755698
60Aplasia/hypoplasia of the uterus (HP:0008684)1.99900295
61* Cystic liver disease (HP:0006706)1.98063219
62* Postaxial foot polydactyly (HP:0001830)1.98060671
63Lactic acidosis (HP:0003128)1.96981677
64Abnormality of the fovea (HP:0000493)1.95989799
65Male infertility (HP:0003251)1.95809421
66* Sclerocornea (HP:0000647)1.95227634
67* Aganglionic megacolon (HP:0002251)1.94764845
68Cerebral hypomyelination (HP:0006808)1.93843940
69* Occipital encephalocele (HP:0002085)1.92534031
70Unsteady gait (HP:0002317)1.89942267
71Aplasia/Hypoplasia of the sternum (HP:0006714)1.87523804
72Abnormality of renal resorption (HP:0011038)1.86723767
73Fibular aplasia (HP:0002990)1.84849375
74Tubulointerstitial nephritis (HP:0001970)1.84207125
75Myokymia (HP:0002411)1.83991527
76Secondary amenorrhea (HP:0000869)1.81372258
77Abnormal hair whorl (HP:0010721)1.81156200
78Optic disc pallor (HP:0000543)1.80915063
79Specific learning disability (HP:0001328)1.79820800
80Macrocytic anemia (HP:0001972)1.79736201
81Increased CSF lactate (HP:0002490)1.78556601
82Chronic hepatic failure (HP:0100626)1.77996390
83Increased serum lactate (HP:0002151)1.77904905
84Delusions (HP:0000746)1.76788807
85* Multicystic kidney dysplasia (HP:0000003)1.76552735
86Decreased testicular size (HP:0008734)1.76297613
87Reticulocytopenia (HP:0001896)1.76019861
88Focal motor seizures (HP:0011153)1.74038991
89* Congenital hepatic fibrosis (HP:0002612)1.73675973
90Increased muscle lipid content (HP:0009058)1.72615495
91Hypoplasia of the fovea (HP:0007750)1.72239052
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.72239052
93Adrenal hypoplasia (HP:0000835)1.70121931
94Colon cancer (HP:0003003)1.69893022
95Birth length less than 3rd percentile (HP:0003561)1.69272015
963-Methylglutaconic aciduria (HP:0003535)1.68762188
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66575365
98Abnormality of glycolysis (HP:0004366)1.65086474
99Increased serum pyruvate (HP:0003542)1.65086474
100Glycosuria (HP:0003076)1.63949000
101Abnormality of urine glucose concentration (HP:0011016)1.63949000
102Hyperinsulinemic hypoglycemia (HP:0000825)1.63180204
103Exercise intolerance (HP:0003546)1.62346572
104Type I transferrin isoform profile (HP:0003642)1.62189679
105Absent eyebrow (HP:0002223)1.62184457
106* Anencephaly (HP:0002323)1.62104970
107Abnormal biliary tract physiology (HP:0012439)1.62005461
108Bile duct proliferation (HP:0001408)1.62005461
109Lethargy (HP:0001254)1.61360199
110Abdominal situs inversus (HP:0003363)1.61141270
111Abnormality of abdominal situs (HP:0011620)1.61141270
112Sex reversal (HP:0012245)1.61022402
113Abnormal sex determination (HP:0012244)1.61022402
114Leukodystrophy (HP:0002415)1.60422470
115Tubular atrophy (HP:0000092)1.60149260
116Limb dystonia (HP:0002451)1.59583765
117Methylmalonic acidemia (HP:0002912)1.59386036
118Atelectasis (HP:0100750)1.58317812
119Abnormal lung lobation (HP:0002101)1.58301059
120Decreased activity of mitochondrial respiratory chain (HP:0008972)1.57949234
121Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.57949234
122Exertional dyspnea (HP:0002875)1.57292282
123Abnormal connection of the cardiac segments (HP:0011545)1.57262491
124Carpal bone hypoplasia (HP:0001498)1.56710535
125* Oculomotor apraxia (HP:0000657)1.56480731
126Dental crowding (HP:0000678)1.56382816
127Anophthalmia (HP:0000528)1.55910561
128Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.54696288
129Absent forearm bone (HP:0003953)1.53557738
130Aplasia involving forearm bones (HP:0009822)1.53557738
131* Male pseudohermaphroditism (HP:0000037)1.52931153
132Breast aplasia (HP:0100783)1.50791978
133Abnormality of the aortic arch (HP:0012303)1.50225369
134Abnormality of the anterior horn cell (HP:0006802)1.49918144
135Degeneration of anterior horn cells (HP:0002398)1.49918144
136Horseshoe kidney (HP:0000085)1.49666520
137Absent radius (HP:0003974)1.49586009
138Aplasia/Hypoplasia of the breasts (HP:0010311)1.49432365

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.93066707
2PLK43.46677084
3BUB13.24859255
4STK38L2.87319613
5PRKD32.82633514
6CASK2.74690643
7MST42.51089861
8PNCK2.44572013
9ARAF2.39558383
10BRAF2.38745000
11TESK12.25853893
12BMPR22.15678319
13BCKDK1.95949405
14CDC71.92723980
15LATS21.86245191
16ERBB31.85130570
17NEK11.83335478
18VRK11.79953218
19PLK21.79826565
20TTK1.78915023
21NME21.78447016
22PLK31.76318856
23ZAK1.71220268
24SRPK11.63379676
25MAP4K21.61300183
26MAPK131.60519360
27DYRK21.56164088
28NUAK11.55294845
29LIMK11.45307916
30TNIK1.44340952
31PASK1.42950110
32TLK11.38130444
33AKT31.37887171
34CSNK1G11.37165210
35MAP3K121.36347485
36CSNK1G21.33758536
37PDK41.32662654
38PDK31.32662654
39TRIM281.31090460
40PLK11.28614057
41MUSK1.28311736
42WNK31.25133964
43WEE11.23492809
44MAPK151.21897374
45AURKA1.16925527
46TAF11.14930278
47CSNK1A1L1.14390444
48BRSK21.13926423
49CDK81.12218289
50BCR1.11663559
51KSR11.11213700
52STK161.09678505
53CHEK21.06735902
54CDK31.06088746
55BRSK11.01990931
56MAPKAPK31.00746130
57ERBB40.96419126
58NTRK30.96200370
59GRK10.94975903
60MAP3K90.92553357
61MKNK20.90055395
62NME10.88578670
63NEK20.86683430
64PRKCI0.86575144
65NTRK20.86102119
66TSSK60.85865985
67MKNK10.85795436
68STK240.82402704
69PBK0.81130536
70AURKB0.79785410
71MAP2K70.79778201
72STK40.78496147
73PHKG10.77886829
74PHKG20.77886829
75EIF2AK10.77720260
76MAP3K40.75576412
77PIM20.75318403
78ABL20.73880757
79WNK40.73509060
80MINK10.73021273
81CDK180.72913111
82DYRK30.72483848
83EPHA40.72180685
84TESK20.72077610
85NEK60.69958353
86BMPR1B0.69401845
87LATS10.68920226
88DAPK10.68419431
89CDK140.68330188
90CAMK2A0.67699272
91PDK20.67388612
92MOS0.66130106
93CDK190.65616026
94CDK150.65253989
95KSR20.64715735
96EIF2AK30.64707562
97RAF10.62613105
98CDK11A0.59485161
99FRK0.59346723
100PAK40.59163006
101CHEK10.58371666
102EPHA20.58140861
103PINK10.56641788
104CAMK2B0.56004451
105CCNB10.55869796
106SIK30.55231877
107GRK50.52552922
108MAP3K60.52433800
109MAPKAPK50.52357396
110CSNK1E0.52252019
111DYRK1A0.52057275
112IRAK10.51926204
113CSNK2A10.51155655
114CSNK2A20.51100498
115PRPF4B0.50511988
116FER0.49815478
117SMG10.49699064
118MARK10.48797693
119CSNK1G30.48153982
120EPHB20.47818117
121PAK30.47155689
122ACVR1B0.46759550
123PRKCE0.46476068
124ILK0.45315079
125CAMK2G0.44917662
126PAK10.44849320
127SGK2230.44650919
128SGK4940.44650919
129PRKCG0.43064063
130ATM0.42919825
131IRAK20.42712075
132MYLK0.42154594
133AKT20.40077052
134ATR0.40003817
135INSRR0.39783557
136RPS6KA50.38892218
137LRRK20.38779089
138CSNK1A10.38485722

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.29907014
2Protein export_Homo sapiens_hsa030603.15555620
3Oxidative phosphorylation_Homo sapiens_hsa001902.99332056
4Proteasome_Homo sapiens_hsa030502.70498490
5Huntingtons disease_Homo sapiens_hsa050162.63375044
6Basal transcription factors_Homo sapiens_hsa030222.55756334
7Parkinsons disease_Homo sapiens_hsa050122.50604167
8Mismatch repair_Homo sapiens_hsa034302.22771769
9Spliceosome_Homo sapiens_hsa030402.08962803
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07641522
11RNA transport_Homo sapiens_hsa030132.03713803
12Pyrimidine metabolism_Homo sapiens_hsa002401.93279609
13DNA replication_Homo sapiens_hsa030301.91741992
14Cell cycle_Homo sapiens_hsa041101.89568155
15Ribosome_Homo sapiens_hsa030101.88938131
16Nucleotide excision repair_Homo sapiens_hsa034201.84726864
17Homologous recombination_Homo sapiens_hsa034401.83385092
18Alzheimers disease_Homo sapiens_hsa050101.82692789
19Sulfur relay system_Homo sapiens_hsa041221.81727778
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78073012
21Folate biosynthesis_Homo sapiens_hsa007901.77041506
22RNA degradation_Homo sapiens_hsa030181.72537102
23Fatty acid elongation_Homo sapiens_hsa000621.67480898
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62882497
25Purine metabolism_Homo sapiens_hsa002301.60953999
26Base excision repair_Homo sapiens_hsa034101.50765091
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.49524947
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46503736
29Oocyte meiosis_Homo sapiens_hsa041141.45676385
30Non-homologous end-joining_Homo sapiens_hsa034501.45282785
31Nicotine addiction_Homo sapiens_hsa050331.44281504
32Vibrio cholerae infection_Homo sapiens_hsa051101.43777130
33Fanconi anemia pathway_Homo sapiens_hsa034601.43589091
34Propanoate metabolism_Homo sapiens_hsa006401.42296180
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40881223
36Collecting duct acid secretion_Homo sapiens_hsa049661.36375151
37Cardiac muscle contraction_Homo sapiens_hsa042601.31767158
38Steroid biosynthesis_Homo sapiens_hsa001001.29267014
39Olfactory transduction_Homo sapiens_hsa047401.28383932
40mRNA surveillance pathway_Homo sapiens_hsa030151.28257581
41Synaptic vesicle cycle_Homo sapiens_hsa047211.25596846
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25206363
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22626062
44Amphetamine addiction_Homo sapiens_hsa050311.21809217
45Hedgehog signaling pathway_Homo sapiens_hsa043401.18865048
46Insulin secretion_Homo sapiens_hsa049111.17899979
47Linoleic acid metabolism_Homo sapiens_hsa005911.17099804
48Phototransduction_Homo sapiens_hsa047441.15860359
49beta-Alanine metabolism_Homo sapiens_hsa004101.15461847
50Basal cell carcinoma_Homo sapiens_hsa052171.15420455
51Butanoate metabolism_Homo sapiens_hsa006501.14499167
52Phenylalanine metabolism_Homo sapiens_hsa003601.14308151
53Serotonergic synapse_Homo sapiens_hsa047261.08315191
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06043453
55Tyrosine metabolism_Homo sapiens_hsa003501.03232962
56Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02190971
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01416314
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01303013
59Biosynthesis of amino acids_Homo sapiens_hsa012300.99800958
60Peroxisome_Homo sapiens_hsa041460.99350207
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99183800
62Taste transduction_Homo sapiens_hsa047420.96242014
63Ether lipid metabolism_Homo sapiens_hsa005650.96012850
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95814453
65Chemical carcinogenesis_Homo sapiens_hsa052040.94803864
66Vitamin B6 metabolism_Homo sapiens_hsa007500.94509436
67Dopaminergic synapse_Homo sapiens_hsa047280.92648281
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91362133
69Cocaine addiction_Homo sapiens_hsa050300.91033967
70Selenocompound metabolism_Homo sapiens_hsa004500.89957524
71GABAergic synapse_Homo sapiens_hsa047270.89313593
72Circadian rhythm_Homo sapiens_hsa047100.89197117
73Carbon metabolism_Homo sapiens_hsa012000.88951875
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87590093
75Alcoholism_Homo sapiens_hsa050340.87532957
76TGF-beta signaling pathway_Homo sapiens_hsa043500.86636393
77Long-term potentiation_Homo sapiens_hsa047200.86300389
78Hippo signaling pathway_Homo sapiens_hsa043900.86206607
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84762050
80Fatty acid degradation_Homo sapiens_hsa000710.82921909
81Arachidonic acid metabolism_Homo sapiens_hsa005900.82635754
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81406703
83One carbon pool by folate_Homo sapiens_hsa006700.80547087
84Glutamatergic synapse_Homo sapiens_hsa047240.79975896
85Arginine and proline metabolism_Homo sapiens_hsa003300.78901157
86Melanogenesis_Homo sapiens_hsa049160.75554270
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75410609
88Morphine addiction_Homo sapiens_hsa050320.74310963
89Circadian entrainment_Homo sapiens_hsa047130.74032677
90Wnt signaling pathway_Homo sapiens_hsa043100.72639263
91Fatty acid metabolism_Homo sapiens_hsa012120.70632314
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67823227
93Pyruvate metabolism_Homo sapiens_hsa006200.65879441
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63051100
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61426434
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61172149
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59242851
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57262467
99Retinol metabolism_Homo sapiens_hsa008300.56675502
100Histidine metabolism_Homo sapiens_hsa003400.55006949
101Epstein-Barr virus infection_Homo sapiens_hsa051690.52969666
102Tryptophan metabolism_Homo sapiens_hsa003800.52389145
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.51908439
104Regulation of autophagy_Homo sapiens_hsa041400.51043060
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50977878
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50854010
107p53 signaling pathway_Homo sapiens_hsa041150.50247613
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50128231
109Glucagon signaling pathway_Homo sapiens_hsa049220.49097704
110Long-term depression_Homo sapiens_hsa047300.48083343
111Tight junction_Homo sapiens_hsa045300.46689980
112Sphingolipid metabolism_Homo sapiens_hsa006000.45741864
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45234946
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44812187
115Metabolic pathways_Homo sapiens_hsa011000.44413007
116Thyroid hormone synthesis_Homo sapiens_hsa049180.43886276
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43380243
118Ovarian steroidogenesis_Homo sapiens_hsa049130.42572287
119Gap junction_Homo sapiens_hsa045400.42453567
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42451525
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42277323
122Cholinergic synapse_Homo sapiens_hsa047250.42145567
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41518265
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40187569
125Fructose and mannose metabolism_Homo sapiens_hsa000510.39470685
126Sulfur metabolism_Homo sapiens_hsa009200.38833333
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36932800
128N-Glycan biosynthesis_Homo sapiens_hsa005100.36046649
129Galactose metabolism_Homo sapiens_hsa000520.35593544
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35047391
131Arginine biosynthesis_Homo sapiens_hsa002200.33913250
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33102599
133Thyroid cancer_Homo sapiens_hsa052160.32282371
134Estrogen signaling pathway_Homo sapiens_hsa049150.31916046
135Melanoma_Homo sapiens_hsa052180.31660184
136GnRH signaling pathway_Homo sapiens_hsa049120.29202259
137Glutathione metabolism_Homo sapiens_hsa004800.28415161
138Bladder cancer_Homo sapiens_hsa052190.26773304
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.25794843
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.24616871
141Prostate cancer_Homo sapiens_hsa052150.23243954
142Axon guidance_Homo sapiens_hsa043600.22581565

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