B9D2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a B9 domain protein, which are exclusively found in ciliated organisms. The gene is upregulated during mucociliary differentiation, and the encoded protein localizes to basal bodies and cilia. Disrupting expression of this gene results in ciliogenesis defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.86281793
2axonemal dynein complex assembly (GO:0070286)5.96215519
3DNA deamination (GO:0045006)5.51676051
4epithelial cilium movement (GO:0003351)5.47610039
5cilium movement (GO:0003341)5.05181055
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.81949053
7viral transcription (GO:0019083)4.79374159
8translational termination (GO:0006415)4.59520817
9telomere maintenance via semi-conservative replication (GO:0032201)4.47689494
10axoneme assembly (GO:0035082)4.46208973
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.40809466
12cotranslational protein targeting to membrane (GO:0006613)4.33697160
13protein targeting to ER (GO:0045047)4.27154627
14ribosomal small subunit biogenesis (GO:0042274)4.25112150
15cilium or flagellum-dependent cell motility (GO:0001539)4.21841019
16translational elongation (GO:0006414)4.18268127
17DNA strand elongation involved in DNA replication (GO:0006271)4.15033223
18protein localization to endoplasmic reticulum (GO:0070972)4.06602067
19maturation of SSU-rRNA (GO:0030490)4.04370663
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.02276113
21DNA strand elongation (GO:0022616)3.96435793
22telomere maintenance via recombination (GO:0000722)3.94040189
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.79797732
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77546342
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77546342
26mannosylation (GO:0097502)3.72641160
27regulation of cilium movement (GO:0003352)3.70296633
28response to pheromone (GO:0019236)3.69267515
29viral life cycle (GO:0019058)3.68570399
30cellular protein complex disassembly (GO:0043624)3.63609401
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.55930301
32mitotic recombination (GO:0006312)3.51647234
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.51219865
34motile cilium assembly (GO:0044458)3.45226088
35translational initiation (GO:0006413)3.43062717
36negative regulation of phagocytosis (GO:0050765)3.40156072
37sequestering of actin monomers (GO:0042989)3.37356316
38platelet dense granule organization (GO:0060155)3.35956056
39intraciliary transport (GO:0042073)3.33727693
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.31318955
41regulation of B cell apoptotic process (GO:0002902)3.31042875
42purine deoxyribonucleotide catabolic process (GO:0009155)3.29424407
43base-excision repair, AP site formation (GO:0006285)3.26432409
44telomere maintenance via telomere lengthening (GO:0010833)3.26143657
45protein complex disassembly (GO:0043241)3.25519572
46DNA replication initiation (GO:0006270)3.24414255
47positive regulation of B cell differentiation (GO:0045579)3.23157448
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.22852953
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22538419
50polyketide metabolic process (GO:0030638)3.22454238
51doxorubicin metabolic process (GO:0044598)3.22454238
52daunorubicin metabolic process (GO:0044597)3.22454238
53negative regulation of B cell apoptotic process (GO:0002903)3.22149865
54protein polyglutamylation (GO:0018095)3.19523477
55respiratory chain complex IV assembly (GO:0008535)3.19462795
56GPI anchor metabolic process (GO:0006505)3.17272838
57preassembly of GPI anchor in ER membrane (GO:0016254)3.16946804
58proteasome assembly (GO:0043248)3.16523229
59translation (GO:0006412)3.16311399
60pseudouridine synthesis (GO:0001522)3.14442135
61GPI anchor biosynthetic process (GO:0006506)3.12697691
62cellular response to interferon-beta (GO:0035458)3.12560762
63purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.12238458
64macromolecular complex disassembly (GO:0032984)3.11606030
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10687045
66GTP biosynthetic process (GO:0006183)3.08044974
67protein complex biogenesis (GO:0070271)3.07798074
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06229319
69guanosine-containing compound biosynthetic process (GO:1901070)3.04522001
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.04482433
71protein localization to cilium (GO:0061512)3.02237969
72energy coupled proton transport, down electrochemical gradient (GO:0015985)2.99357411
73ATP synthesis coupled proton transport (GO:0015986)2.99357411
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.99295537
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.99295537
76NADH dehydrogenase complex assembly (GO:0010257)2.99295537
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97862067
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97862067
79DNA unwinding involved in DNA replication (GO:0006268)2.97643223
80response to interferon-beta (GO:0035456)2.96623219
81cytochrome complex assembly (GO:0017004)2.96413350
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96309192
83chaperone-mediated protein transport (GO:0072321)2.95181025
84definitive hemopoiesis (GO:0060216)2.94537074
85cell wall macromolecule catabolic process (GO:0016998)2.93306809
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93142305
87mitochondrial respiratory chain complex assembly (GO:0033108)2.92909812
88lymphoid progenitor cell differentiation (GO:0002320)2.92010400
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90004605
90nuclear-transcribed mRNA catabolic process (GO:0000956)2.89955112
91adaptation of signaling pathway (GO:0023058)2.89562226
92metallo-sulfur cluster assembly (GO:0031163)2.88606314
93iron-sulfur cluster assembly (GO:0016226)2.88606314
94intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87970432
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87970432
96intra-S DNA damage checkpoint (GO:0031573)2.85736397
97pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84670428
98deoxyribose phosphate catabolic process (GO:0046386)2.84262039
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84253148
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84253148
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84253148
102cell wall macromolecule metabolic process (GO:0044036)2.83546781
103deoxyribonucleotide catabolic process (GO:0009264)2.83381824
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83103184
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82997337
106CENP-A containing nucleosome assembly (GO:0034080)2.82441058
107negative regulation of ligase activity (GO:0051352)2.81154716
108negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81154716
109negative regulation of mast cell activation (GO:0033004)2.80747691
110antigen processing and presentation of endogenous antigen (GO:0019883)2.80672679
111purine-containing compound salvage (GO:0043101)2.79161104
112ribosomal large subunit biogenesis (GO:0042273)2.78340877
113ribonucleoprotein complex biogenesis (GO:0022613)2.78081824
114protein targeting to membrane (GO:0006612)2.78009673
115regulation of cellular amino acid metabolic process (GO:0006521)2.77017779
116mRNA catabolic process (GO:0006402)2.76607506
117UTP biosynthetic process (GO:0006228)2.74293528
118histone H2A acetylation (GO:0043968)2.73997911
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.73173018
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72743454
121cilium morphogenesis (GO:0060271)2.72304266
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71993774
123nonmotile primary cilium assembly (GO:0035058)2.71881501
124C-terminal protein lipidation (GO:0006501)2.71604313
125CTP biosynthetic process (GO:0006241)2.71387831
126CTP metabolic process (GO:0046036)2.71387831
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69579258
128signal transduction involved in DNA damage checkpoint (GO:0072422)2.69579258
129formation of translation preinitiation complex (GO:0001731)2.68998600
130termination of RNA polymerase III transcription (GO:0006386)2.68903848
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.68903848
132protein neddylation (GO:0045116)2.68776225
133signal transduction involved in cell cycle checkpoint (GO:0072395)2.68351462
134negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67335502
135cellular component biogenesis (GO:0044085)2.67258600
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67112815
137DNA ligation (GO:0006266)2.67092710
138* cilium organization (GO:0044782)2.66975022
139purine deoxyribonucleotide metabolic process (GO:0009151)2.66910990
140Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66687716
141ubiquinone biosynthetic process (GO:0006744)2.65954712
142regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.63645430
143protein-cofactor linkage (GO:0018065)2.61561922
144positive regulation of T cell differentiation in thymus (GO:0033089)2.61003238
145piRNA metabolic process (GO:0034587)2.57741192
146pyrimidine nucleotide catabolic process (GO:0006244)2.57103704
147deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.55944587
148amino acid salvage (GO:0043102)2.54571150
149L-methionine salvage (GO:0071267)2.54571150
150L-methionine biosynthetic process (GO:0071265)2.54571150
151negative regulation of interleukin-1 beta production (GO:0032691)2.54167996
152* cilium assembly (GO:0042384)2.53884671
153left/right axis specification (GO:0070986)2.49512850
154negative regulation of interleukin-1 production (GO:0032692)2.43732412
155positive regulation of prostaglandin secretion (GO:0032308)2.43514895
156ubiquinone metabolic process (GO:0006743)2.42955717
157C-terminal protein amino acid modification (GO:0018410)2.42688732
158regulation of germinal center formation (GO:0002634)2.40674446
159cytidine deamination (GO:0009972)2.40663600
160cytidine metabolic process (GO:0046087)2.40663600
161cytidine catabolic process (GO:0006216)2.40663600
162autophagic vacuole fusion (GO:0000046)2.39859120
163tolerance induction (GO:0002507)2.39755991
164centriole replication (GO:0007099)2.39476056
165male meiosis I (GO:0007141)2.37011453
166ATP hydrolysis coupled proton transport (GO:0015991)2.34968454
167energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.34968454
1682-deoxyribonucleotide metabolic process (GO:0009394)2.34562652
169peptidyl-histidine modification (GO:0018202)2.34549928
170meiosis I (GO:0007127)2.34200182
171glycolipid biosynthetic process (GO:0009247)2.33462849
172negative regulation of telomere maintenance (GO:0032205)2.31627974
173left/right pattern formation (GO:0060972)2.31453227
174organic cation transport (GO:0015695)2.29774752
175L-fucose metabolic process (GO:0042354)2.28029206
176L-fucose catabolic process (GO:0042355)2.28029206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.55118944
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77269575
3ZNF274_21170338_ChIP-Seq_K562_Hela3.47749428
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.37257742
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31577246
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.31533680
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.29097862
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.27696829
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25403236
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.23009527
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17016648
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03249014
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.88741063
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.78101743
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55601344
16* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.52906949
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50513785
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49422886
19VDR_23849224_ChIP-Seq_CD4+_Human2.47537335
20* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.44143843
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41390025
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35478374
23SCL_19346495_ChIP-Seq_HPC-7_Human2.35430621
24VDR_22108803_ChIP-Seq_LS180_Human2.28768095
25FOXP3_21729870_ChIP-Seq_TREG_Human2.28212628
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25703262
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.25416339
28HOXB4_20404135_ChIP-ChIP_EML_Mouse2.21384627
29* SRF_21415370_ChIP-Seq_HL-1_Mouse2.20668595
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13746513
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12263383
32* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10300924
33* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09840604
34XRN2_22483619_ChIP-Seq_HELA_Human2.08377700
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05365267
36ERG_20887958_ChIP-Seq_HPC-7_Mouse2.03890847
37* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03352153
38THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01420738
39DCP1A_22483619_ChIP-Seq_HELA_Human1.99473304
40* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.98739798
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94475728
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.86127237
43GABP_19822575_ChIP-Seq_HepG2_Human1.84322472
44* CIITA_25753668_ChIP-Seq_RAJI_Human1.83639919
45VDR_21846776_ChIP-Seq_THP-1_Human1.83335845
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.83280767
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78251581
48TTF2_22483619_ChIP-Seq_HELA_Human1.78173501
49ELK1_19687146_ChIP-ChIP_HELA_Human1.78090308
50SPI1_23547873_ChIP-Seq_NB4_Human1.77694276
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76957552
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.72296395
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71456925
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70395742
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70238423
56IGF1R_20145208_ChIP-Seq_DFB_Human1.67428019
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67314118
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.66946043
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66243427
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66037724
61MYC_22102868_ChIP-Seq_BL_Human1.65698791
62IRF1_19129219_ChIP-ChIP_H3396_Human1.64999774
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61424565
64GATA3_26560356_Chip-Seq_TH2_Human1.59371176
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58787738
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.58710304
67IRF8_21731497_ChIP-ChIP_J774_Mouse1.57268238
68* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56576692
69* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55583904
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52601694
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51845334
72TP53_22573176_ChIP-Seq_HFKS_Human1.48472961
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48393424
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.44381542
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.42357153
76* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38272613
77* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35926880
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34256300
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32308389
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.32266551
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31964931
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.30418941
83AR_20517297_ChIP-Seq_VCAP_Human1.29254331
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28406857
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.28406857
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27795649
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26846027
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26511578
89VDR_24763502_ChIP-Seq_THP-1_Human1.26159797
90* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24197369
91NANOG_20526341_ChIP-Seq_ESCs_Human1.21083539
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20924028
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.20431263
94MYB_26560356_Chip-Seq_TH2_Human1.20053784
95BCL6_27268052_Chip-Seq_Bcells_Human1.19648758
96* NCOR_22424771_ChIP-Seq_293T_Human1.19247703
97* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18063521
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16515893
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.16295862
100GATA3_27048872_Chip-Seq_THYMUS_Human1.14700838
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13727788
102EWS_26573619_Chip-Seq_HEK293_Human1.12146722
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11019611
104FLI1_27457419_Chip-Seq_LIVER_Mouse1.09812608
105GATA1_22025678_ChIP-Seq_K562_Human1.09007636
106MYC_18940864_ChIP-ChIP_HL60_Human1.08441384
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07774651
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07049024
109ERA_21632823_ChIP-Seq_H3396_Human1.06829935
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04666737
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03272747
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03086749
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03039570
114YY1_22570637_ChIP-Seq_MALME-3M_Human1.02841147
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02641715
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01808553
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01465576
118EZH2_22144423_ChIP-Seq_EOC_Human1.01378161
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01097559
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01013815
121MAF_26560356_Chip-Seq_TH1_Human1.00442035
122MYC_19829295_ChIP-Seq_ESCs_Human1.00435734
123OCT4_20526341_ChIP-Seq_ESCs_Human0.99502473
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99500285
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99441229
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99165694
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97950704
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97837871
129FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97485397
130EGR1_19374776_ChIP-ChIP_THP-1_Human0.97062636
131CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96779486
132TAF2_19829295_ChIP-Seq_ESCs_Human0.96612266
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96495475
134KDM5A_27292631_Chip-Seq_BREAST_Human0.96454894
135TFEB_21752829_ChIP-Seq_HELA_Human0.96396052
136TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96271791
137RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94550687
138MYB_26560356_Chip-Seq_TH1_Human0.93917644
139SOX2_19829295_ChIP-Seq_ESCs_Human0.93762193
140NANOG_19829295_ChIP-Seq_ESCs_Human0.93762193
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93551226
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93385647
143PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92951901
144* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92629815
145TAF15_26573619_Chip-Seq_HEK293_Human0.92335775
146UTX_26944678_Chip-Seq_JUKART_Human0.92279358
147HTT_18923047_ChIP-ChIP_STHdh_Human0.91962389
148STAT1_20625510_ChIP-Seq_HELA_Human0.91794876
149CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90970286
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.90823340
151E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89196153
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89029560
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87316344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.78978272
2MP0001835_abnormal_antigen_presentation3.55128974
3MP0002653_abnormal_ependyma_morphology3.12493395
4MP0009785_altered_susceptibility_to2.80044415
5MP0008875_abnormal_xenobiotic_pharmacok2.77738406
6MP0008057_abnormal_DNA_replication2.73026019
7MP0005671_abnormal_response_to2.72916763
8MP0003763_abnormal_thymus_physiology2.53024184
9MP0010094_abnormal_chromosome_stability2.49903862
10MP0001545_abnormal_hematopoietic_system2.44061459
11MP0005397_hematopoietic_system_phenotyp2.44061459
12MP0005174_abnormal_tail_pigmentation2.42940312
13MP0003693_abnormal_embryo_hatching2.40652929
14MP0008058_abnormal_DNA_repair2.40575128
15MP0000685_abnormal_immune_system2.35350087
16MP0005075_abnormal_melanosome_morpholog2.30693927
17* MP0002398_abnormal_bone_marrow2.28279187
18MP0003077_abnormal_cell_cycle2.19475199
19MP0005025_abnormal_response_to2.18549017
20MP0004808_abnormal_hematopoietic_stem2.18001953
21MP0002148_abnormal_hypersensitivity_rea2.17595470
22MP0001800_abnormal_humoral_immune2.16630455
23* MP0002420_abnormal_adaptive_immunity2.14836654
24MP0002277_abnormal_respiratory_mucosa2.13818997
25MP0009333_abnormal_splenocyte_physiolog2.12533392
26* MP0001819_abnormal_immune_cell2.10973630
27MP0003724_increased_susceptibility_to2.09742152
28* MP0005000_abnormal_immune_tolerance2.05562303
29MP0002452_abnormal_antigen_presenting2.05157341
30MP0003806_abnormal_nucleotide_metabolis2.00819262
31MP0003436_decreased_susceptibility_to1.97905727
32* MP0002723_abnormal_immune_serum1.97450414
33MP0002102_abnormal_ear_morphology1.97384170
34MP0003136_yellow_coat_color1.94722562
35MP0009379_abnormal_foot_pigmentation1.94528664
36MP0000689_abnormal_spleen_morphology1.94210862
37* MP0000716_abnormal_immune_system1.91859276
38MP0003195_calcinosis1.84987626
39MP0008007_abnormal_cellular_replicative1.84600974
40MP0002722_abnormal_immune_system1.82882306
41MP0002419_abnormal_innate_immunity1.81981378
42MP0005464_abnormal_platelet_physiology1.80295912
43* MP0002429_abnormal_blood_cell1.79233843
44MP0004957_abnormal_blastocyst_morpholog1.78867988
45MP0003787_abnormal_imprinting1.78326588
46MP0002095_abnormal_skin_pigmentation1.78255282
47* MP0000490_abnormal_crypts_of1.77675217
48MP0006072_abnormal_retinal_apoptosis1.76894530
49MP0001853_heart_inflammation1.76014579
50MP0003111_abnormal_nucleus_morphology1.74984645
51MP0009764_decreased_sensitivity_to1.71673745
52MP0002405_respiratory_system_inflammati1.66457507
53MP0003011_delayed_dark_adaptation1.65633039
54MP0001790_abnormal_immune_system1.65205134
55MP0005387_immune_system_phenotype1.65205134
56MP0001873_stomach_inflammation1.63901505
57MP0000465_gastrointestinal_hemorrhage1.62289045
58MP0004147_increased_porphyrin_level1.60912547
59MP0000703_abnormal_thymus_morphology1.54087450
60MP0006036_abnormal_mitochondrial_physio1.54066402
61MP0000015_abnormal_ear_pigmentation1.52060430
62MP0001529_abnormal_vocalization1.52005722
63MP0003880_abnormal_central_pattern1.50478247
64MP0002837_dystrophic_cardiac_calcinosis1.47347614
65MP0005551_abnormal_eye_electrophysiolog1.43984892
66MP0002132_abnormal_respiratory_system1.41000248
67MP0001986_abnormal_taste_sensitivity1.40015060
68MP0001968_abnormal_touch/_nociception1.37927612
69MP0003656_abnormal_erythrocyte_physiolo1.37869120
70MP0002638_abnormal_pupillary_reflex1.36658440
71MP0006054_spinal_hemorrhage1.35670577
72MP0006292_abnormal_olfactory_placode1.34615219
73MP0002736_abnormal_nociception_after1.33998321
74MP0002019_abnormal_tumor_incidence1.31224070
75MP0005367_renal/urinary_system_phenotyp1.31171935
76MP0000516_abnormal_urinary_system1.31171935
77MP0003186_abnormal_redox_activity1.30465652
78MP0004133_heterotaxia1.26291569
79MP0005253_abnormal_eye_physiology1.24707748
80MP0002928_abnormal_bile_duct1.22205996
81* MP0001845_abnormal_inflammatory_respons1.21864871
82MP0008872_abnormal_physiological_respon1.21302686
83MP0003786_premature_aging1.20906468
84MP0004142_abnormal_muscle_tone1.20657993
85MP0002166_altered_tumor_susceptibility1.19817718
86MP0005423_abnormal_somatic_nervous1.16468148
87MP0005389_reproductive_system_phenotype1.16281880
88MP0000858_altered_metastatic_potential1.14065720
89* MP0010155_abnormal_intestine_physiology1.13171322
90MP0000313_abnormal_cell_death1.12043729
91MP0001188_hyperpigmentation1.11870420
92MP0006082_CNS_inflammation1.11420135
93* MP0003866_abnormal_defecation1.10972127
94MP0002006_tumorigenesis1.06613861
95MP0002234_abnormal_pharynx_morphology1.05356740
96MP0001905_abnormal_dopamine_level1.03303472
97MP0002282_abnormal_trachea_morphology1.02921006
98MP0003943_abnormal_hepatobiliary_system1.02544917
99MP0002822_catalepsy1.01758469
100MP0001764_abnormal_homeostasis1.00790818
101MP0004883_abnormal_blood_vessel1.00563009
102MP0002160_abnormal_reproductive_system0.99286228
103MP0008932_abnormal_embryonic_tissue0.98070469
104MP0001984_abnormal_olfaction0.97008758
105* MP0008469_abnormal_protein_level0.96752283
106MP0001542_abnormal_bone_strength0.93957460
107MP0005645_abnormal_hypothalamus_physiol0.93704427
108MP0000372_irregular_coat_pigmentation0.93238493
109MP0009697_abnormal_copulation0.92301577
110MP0005394_taste/olfaction_phenotype0.92187049
111MP0005499_abnormal_olfactory_system0.92187049
112MP0005379_endocrine/exocrine_gland_phen0.89708015
113MP0002693_abnormal_pancreas_physiology0.89679338
114MP0001663_abnormal_digestive_system0.88658839
115MP0001929_abnormal_gametogenesis0.87917176
116MP0000681_abnormal_thyroid_gland0.87001803
117MP0005083_abnormal_biliary_tract0.85930367
118MP0000631_abnormal_neuroendocrine_gland0.84456688
119MP0004510_myositis0.83847722
120MP0006035_abnormal_mitochondrial_morpho0.81523921
121MP0001919_abnormal_reproductive_system0.80477409
122MP0005266_abnormal_metabolism0.79802642
123MP0009745_abnormal_behavioral_response0.78613312
124MP0004381_abnormal_hair_follicle0.76146492
125MP0001119_abnormal_female_reproductive0.75593750
126MP0000350_abnormal_cell_proliferation0.75054431
127MP0003718_maternal_effect0.73597278
128MP0002876_abnormal_thyroid_physiology0.73030054
129MP0003303_peritoneal_inflammation0.71527667
130MP0001533_abnormal_skeleton_physiology0.70976225
131MP0002933_joint_inflammation0.70489294
132MP0002938_white_spotting0.70145242
133MP0005646_abnormal_pituitary_gland0.70047563
134MP0000343_altered_response_to0.69495255
135MP0008877_abnormal_DNA_methylation0.68739401
136MP0005310_abnormal_salivary_gland0.66739837
137MP0004782_abnormal_surfactant_physiolog0.65072508
138MP0000358_abnormal_cell_content/0.64472089
139MP0009278_abnormal_bone_marrow0.61659445
140MP0008789_abnormal_olfactory_epithelium0.60936661
141MP0008995_early_reproductive_senescence0.58340481
142MP0002163_abnormal_gland_morphology0.57130011
143MP0008873_increased_physiological_sensi0.56725975
144MP0005084_abnormal_gallbladder_morpholo0.56262779
145MP0006276_abnormal_autonomic_nervous0.53402098

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.29554931
2Abnormal respiratory motile cilium physiology (HP:0012261)5.12874319
3Abnormal respiratory epithelium morphology (HP:0012253)5.12757663
4Abnormal respiratory motile cilium morphology (HP:0005938)5.12757663
5Abnormal ciliary motility (HP:0012262)5.00288916
6Absent/shortened dynein arms (HP:0200106)4.93424108
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.93424108
8Abnormal number of erythroid precursors (HP:0012131)4.93021569
9Abnormality of cells of the erythroid lineage (HP:0012130)4.82639819
10Aplastic anemia (HP:0001915)4.35334636
11Rhinitis (HP:0012384)4.18566754
12Thrombocytosis (HP:0001894)4.06414242
13Reticulocytopenia (HP:0001896)4.02913232
14Elevated erythrocyte sedimentation rate (HP:0003565)3.92756728
15IgM deficiency (HP:0002850)3.88720043
16* True hermaphroditism (HP:0010459)3.79278916
17Type I transferrin isoform profile (HP:0003642)3.67640847
18Hepatocellular necrosis (HP:0001404)3.67047360
19Mitochondrial inheritance (HP:0001427)3.56043025
20Petechiae (HP:0000967)3.50346645
21* Pancreatic cysts (HP:0001737)3.41619749
22Acute necrotizing encephalopathy (HP:0006965)3.38730999
23Chronic otitis media (HP:0000389)3.37915846
24Abnormal mitochondria in muscle tissue (HP:0008316)3.28408578
25Increased CSF lactate (HP:0002490)3.23012342
26Recurrent abscess formation (HP:0002722)3.21728682
27Hepatic necrosis (HP:0002605)3.20157970
28Abnormality of midbrain morphology (HP:0002418)3.18927895
29Molar tooth sign on MRI (HP:0002419)3.18927895
30* Pancreatic fibrosis (HP:0100732)3.16379729
31Nephronophthisis (HP:0000090)3.16033788
32Bronchiectasis (HP:0002110)3.15998544
33Medial flaring of the eyebrow (HP:0010747)3.14849961
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13331543
35Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13331543
36Reduced antithrombin III activity (HP:0001976)3.01846761
37Stomatitis (HP:0010280)2.90844039
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.88905709
39Abnormal protein N-linked glycosylation (HP:0012347)2.88905709
40Abnormal protein glycosylation (HP:0012346)2.88905709
41Abnormal glycosylation (HP:0012345)2.88905709
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.86948853
43Chronic bronchitis (HP:0004469)2.85780080
44Pallor (HP:0000980)2.83572796
45Nephrogenic diabetes insipidus (HP:0009806)2.81341880
46Chronic sinusitis (HP:0011109)2.80262055
47Increased serum lactate (HP:0002151)2.77247682
48Increased hepatocellular lipid droplets (HP:0006565)2.75940439
49Congenital primary aphakia (HP:0007707)2.74511963
50Exertional dyspnea (HP:0002875)2.73599698
51Progressive macrocephaly (HP:0004481)2.72337276
52Recurrent bacterial skin infections (HP:0005406)2.71224798
53Recurrent bronchitis (HP:0002837)2.70920566
54Abnormal rod and cone electroretinograms (HP:0008323)2.70349410
55Hypothermia (HP:0002045)2.68381410
56Poikiloderma (HP:0001029)2.67899548
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66298746
58Panhypogammaglobulinemia (HP:0003139)2.64248804
59Myositis (HP:0100614)2.64209394
60Type 2 muscle fiber atrophy (HP:0003554)2.63828737
61Gait imbalance (HP:0002141)2.62553413
62Acute encephalopathy (HP:0006846)2.55968587
633-Methylglutaconic aciduria (HP:0003535)2.53412323
64Muscle fiber atrophy (HP:0100295)2.51795095
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.51666750
66Abnormality of B cell number (HP:0010975)2.50282788
67B lymphocytopenia (HP:0010976)2.50282788
68Degeneration of anterior horn cells (HP:0002398)2.44641029
69Abnormality of the anterior horn cell (HP:0006802)2.44641029
70Abnormality of the renal medulla (HP:0100957)2.44162835
7111 pairs of ribs (HP:0000878)2.41784954
72Meningitis (HP:0001287)2.41714701
73Oral leukoplakia (HP:0002745)2.40626445
74Macrocytic anemia (HP:0001972)2.39998858
75Congenital stationary night blindness (HP:0007642)2.37749165
76Agammaglobulinemia (HP:0004432)2.37489896
77Severe combined immunodeficiency (HP:0004430)2.36276654
78Lipid accumulation in hepatocytes (HP:0006561)2.36086182
79Prolonged bleeding time (HP:0003010)2.35003294
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30393034
81Myelodysplasia (HP:0002863)2.29241760
82Exercise intolerance (HP:0003546)2.29023085
83Entropion (HP:0000621)2.28842376
84Lactic acidosis (HP:0003128)2.28312972
85Increased intramyocellular lipid droplets (HP:0012240)2.27388719
86Respiratory difficulties (HP:0002880)2.25701423
87Decreased central vision (HP:0007663)2.24634358
88Renal Fanconi syndrome (HP:0001994)2.24192632
89IgG deficiency (HP:0004315)2.21197557
90Abnormality of the prostate (HP:0008775)2.19351614
91Nasal polyposis (HP:0100582)2.19339832
92Abnormality of DNA repair (HP:0003254)2.17429526
93Gastrointestinal stroma tumor (HP:0100723)2.17041134
94Abnormality of T cell physiology (HP:0011840)2.15443102
95Recurrent sinusitis (HP:0011108)2.15322610
96Short tibia (HP:0005736)2.12538409
97* Male pseudohermaphroditism (HP:0000037)2.12367636
98Pancytopenia (HP:0001876)2.11957887
99Recurrent viral infections (HP:0004429)2.11877635
100Neoplasm of head and neck (HP:0012288)2.10753967
101Esophageal neoplasm (HP:0100751)2.10753967
102* Anencephaly (HP:0002323)2.09928046
103Concave nail (HP:0001598)2.07783135
104Microretrognathia (HP:0000308)2.07595331
105Lymphoma (HP:0002665)2.07403560
106Neutropenia (HP:0001875)2.06295254
107Abnormal hair whorl (HP:0010721)2.06292358
108Attenuation of retinal blood vessels (HP:0007843)2.05057540
109Severe visual impairment (HP:0001141)2.05005055
110* Sclerocornea (HP:0000647)2.04422767
111Acute lymphatic leukemia (HP:0006721)2.03863115
112Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01024084
113Aplasia/hypoplasia of the uterus (HP:0008684)2.00269191
114Mediastinal lymphadenopathy (HP:0100721)1.99868830
115Cellulitis (HP:0100658)1.99251744
116Thyroiditis (HP:0100646)1.97852992
117Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96859884
118* Cystic liver disease (HP:0006706)1.96131206
119Lymphopenia (HP:0001888)1.95102587
120Bone marrow hypocellularity (HP:0005528)1.95091454
121Chronic obstructive pulmonary disease (HP:0006510)1.94344697
122Obstructive lung disease (HP:0006536)1.94344697
123Aplasia/Hypoplasia of the tibia (HP:0005772)1.93146120
124Microvesicular hepatic steatosis (HP:0001414)1.92351481
125Optic disc pallor (HP:0000543)1.91630948
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.91321511
127Abolished electroretinogram (ERG) (HP:0000550)1.91024512
128Bronchitis (HP:0012387)1.90685589
129Tubular atrophy (HP:0000092)1.89144715
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88253095
131Abnormality of alanine metabolism (HP:0010916)1.88253095
132Hyperalaninemia (HP:0003348)1.88253095
133* Postaxial foot polydactyly (HP:0001830)1.87615551
134Abnormal drinking behavior (HP:0030082)1.87581846
135Polydipsia (HP:0001959)1.87581846
136Respiratory failure (HP:0002878)1.87344915
137Increased muscle lipid content (HP:0009058)1.86842691
138Poor head control (HP:0002421)1.86289545
139Optic nerve coloboma (HP:0000588)1.86220052
140Type II lissencephaly (HP:0007260)1.85153584
141Abnormality of the nasal mucosa (HP:0000433)1.84922523
142Stomach cancer (HP:0012126)1.84558177
143Abnormality of T cells (HP:0002843)1.84176334
144Chromsome breakage (HP:0040012)1.82451952
145Genital tract atresia (HP:0001827)1.82438182
146Recurrent pneumonia (HP:0006532)1.81540618
147* Aplasia/Hypoplasia of the tongue (HP:0010295)1.81486236
148Abnormality of the preputium (HP:0100587)1.81398258
149Hypoplasia of the uterus (HP:0000013)1.81177274
150Increased IgM level (HP:0003496)1.81084233
151Infertility (HP:0000789)1.80340287
152Vaginal atresia (HP:0000148)1.79239612
153Eosinophilia (HP:0001880)1.79042796
154Recurrent fungal infections (HP:0002841)1.78818138
155Aplasia/Hypoplasia of the spleen (HP:0010451)1.78213787
156Vasculitis (HP:0002633)1.76195044
157* Congenital hepatic fibrosis (HP:0002612)1.75177703
158Abnormality of eosinophils (HP:0001879)1.74083576
159Combined immunodeficiency (HP:0005387)1.71844846
160Retinitis pigmentosa (HP:0000510)1.71339609
161* Postaxial hand polydactyly (HP:0001162)1.69632224
162* Occipital encephalocele (HP:0002085)1.69359519
163Abnormality of the renal cortex (HP:0011035)1.68779718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.49276262
2MAP4K23.20661298
3PIM23.06627751
4KIT2.86854815
5FRK2.71783441
6MAP4K12.64301490
7MAP3K122.60281196
8VRK12.43858277
9EIF2AK12.34141386
10TESK22.32317749
11INSRR2.28729757
12VRK22.27472504
13NME22.26441969
14BUB12.24338306
15TEC2.24085164
16CCNB12.08471812
17ZAK2.08098503
18TRIM282.04016466
19BTK2.00407918
20EIF2AK31.99128539
21WEE11.95285986
22IRAK41.92687932
23ARAF1.92280216
24BRSK21.91163552
25MAPK151.85770314
26FLT31.84068071
27ACVR1B1.83268318
28MAP3K41.63496196
29TNIK1.63336837
30MAP2K31.57765728
31GRK71.56072538
32TXK1.52527974
33CDC71.51872974
34SYK1.49045986
35TBK11.46542624
36TLK11.45295300
37WNK31.45033030
38BCR1.44762349
39CDK191.42710136
40NUAK11.38920255
41SIK31.38663222
42BRSK11.36689197
43BLK1.31762436
44DAPK11.29449410
45ZAP701.28250380
46CSF1R1.26005388
47CDK81.25205838
48LIMK11.24337241
49MYLK1.23731505
50GRK11.20204539
51SCYL21.17897005
52TSSK61.16205728
53SIK21.16156792
54SRPK11.15737245
55MAP2K71.15201690
56BRAF1.12557783
57CAMKK21.06976725
58MKNK11.04926221
59BMPR1B1.03479283
60PASK1.02231208
61DYRK31.02057694
62PTK2B1.00717700
63IKBKE0.99573637
64LYN0.99127873
65TGFBR10.98110667
66JAK30.97547978
67CLK10.96534782
68KDR0.92886276
69FES0.90731283
70MUSK0.90668534
71GRK60.90256802
72MAP3K110.88318281
73PLK20.87481973
74EEF2K0.86414178
75RAF10.86391263
76ADRBK10.85460619
77TESK10.85299471
78MATK0.84611281
79IRAK10.83741514
80ATR0.83141822
81CSNK1G30.82926219
82RPS6KB20.82247176
83PIM10.81894645
84PINK10.80869897
85RIPK40.79752937
86IKBKB0.79027205
87ADRBK20.78923081
88PRKCQ0.78514282
89MST40.77638667
90DAPK20.77470953
91RPS6KA60.76922383
92MARK30.76651366
93STK100.76389660
94MAP3K140.76361882
95BMPR20.76028992
96YES10.74351433
97OXSR10.72240790
98TNK20.72135686
99ERBB30.70974279
100ITK0.69320406
101CSNK1G20.69225838
102GRK50.68991754
103PAK30.68502581
104RPS6KA40.68435318
105MAPKAPK50.68430936
106MAPKAPK30.66969585
107PBK0.65846138
108RPS6KL10.65308402
109RPS6KC10.65308402
110TYK20.64548305
111PRKCI0.64365833
112EIF2AK20.63182383
113TAOK30.62614886
114IRAK30.60956158
115CSNK1G10.58734667
116LCK0.57446348
117ILK0.55934247
118MAP3K30.55780339
119CDK70.55665609
120AURKB0.54982635
121NLK0.53982224
122AURKA0.53649310
123TGFBR20.53528392
124HCK0.53108231
125PLK10.51446498
126IRAK20.51414367
127CSK0.50502243
128MAPK40.50467666
129MKNK20.46776711
130LRRK20.46199267
131DYRK20.46173899
132TAOK20.45581070
133RPS6KA20.45313069
134NME10.44340673
135CSNK2A10.43783791
136RPS6KA50.42532422
137MAPK130.40539598
138BCKDK0.40480257
139PRKCE0.40289423
140ABL20.38427811
141STK40.37657876
142MAP3K50.34944613
143CSNK1A1L0.33931970
144FER0.33070044
145WNK40.30174191

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.60170115
2DNA replication_Homo sapiens_hsa030304.53486104
3Proteasome_Homo sapiens_hsa030503.53120072
4Mismatch repair_Homo sapiens_hsa034303.44232241
5Base excision repair_Homo sapiens_hsa034103.21270593
6Homologous recombination_Homo sapiens_hsa034402.62365000
7RNA polymerase_Homo sapiens_hsa030202.59656945
8Nucleotide excision repair_Homo sapiens_hsa034202.46493473
9Spliceosome_Homo sapiens_hsa030402.39363258
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38478846
11Pyrimidine metabolism_Homo sapiens_hsa002402.37366651
12Parkinsons disease_Homo sapiens_hsa050122.31555008
13Oxidative phosphorylation_Homo sapiens_hsa001902.26169753
14Protein export_Homo sapiens_hsa030602.22832169
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.14289083
16Phototransduction_Homo sapiens_hsa047442.11212519
17Primary immunodeficiency_Homo sapiens_hsa053401.98022929
18Collecting duct acid secretion_Homo sapiens_hsa049661.92397945
19Non-homologous end-joining_Homo sapiens_hsa034501.81602489
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73238011
21Caffeine metabolism_Homo sapiens_hsa002321.72056744
22Huntingtons disease_Homo sapiens_hsa050161.68947895
23RNA degradation_Homo sapiens_hsa030181.51434369
24Fanconi anemia pathway_Homo sapiens_hsa034601.50275050
25Alzheimers disease_Homo sapiens_hsa050101.45446439
26Cell cycle_Homo sapiens_hsa041101.43574636
27Purine metabolism_Homo sapiens_hsa002301.42944161
28Butanoate metabolism_Homo sapiens_hsa006501.42322871
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.33010773
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32778874
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32277414
32Autoimmune thyroid disease_Homo sapiens_hsa053201.29348861
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28196184
34Glutathione metabolism_Homo sapiens_hsa004801.26224839
35RNA transport_Homo sapiens_hsa030131.25998586
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24773277
37Peroxisome_Homo sapiens_hsa041461.23403529
38Chemical carcinogenesis_Homo sapiens_hsa052041.22572465
39Basal transcription factors_Homo sapiens_hsa030221.21973185
40N-Glycan biosynthesis_Homo sapiens_hsa005101.20746665
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16572486
42Linoleic acid metabolism_Homo sapiens_hsa005911.16375083
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14840174
44Herpes simplex infection_Homo sapiens_hsa051681.12065425
45Hematopoietic cell lineage_Homo sapiens_hsa046401.11021544
46Leishmaniasis_Homo sapiens_hsa051401.10826522
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10800350
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09412559
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09371375
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09051216
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07670091
52Nitrogen metabolism_Homo sapiens_hsa009101.07536762
53Legionellosis_Homo sapiens_hsa051341.07000307
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04486836
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01499495
56Tryptophan metabolism_Homo sapiens_hsa003801.00411656
57Epstein-Barr virus infection_Homo sapiens_hsa051690.99606126
58Antigen processing and presentation_Homo sapiens_hsa046120.98534178
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.97268817
60Fatty acid elongation_Homo sapiens_hsa000620.97254167
61Measles_Homo sapiens_hsa051620.96452462
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95858375
63B cell receptor signaling pathway_Homo sapiens_hsa046620.95130619
64Allograft rejection_Homo sapiens_hsa053300.93490448
65Shigellosis_Homo sapiens_hsa051310.93239426
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91376198
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86170545
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84185487
69Propanoate metabolism_Homo sapiens_hsa006400.82275407
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81525087
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79827532
72Sulfur metabolism_Homo sapiens_hsa009200.79795218
73p53 signaling pathway_Homo sapiens_hsa041150.76286800
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.75889027
75Asthma_Homo sapiens_hsa053100.75193218
76One carbon pool by folate_Homo sapiens_hsa006700.71370516
77Pentose phosphate pathway_Homo sapiens_hsa000300.69390094
78Acute myeloid leukemia_Homo sapiens_hsa052210.68912945
79Systemic lupus erythematosus_Homo sapiens_hsa053220.67929941
80Tyrosine metabolism_Homo sapiens_hsa003500.66532979
81Type I diabetes mellitus_Homo sapiens_hsa049400.66198547
82Pertussis_Homo sapiens_hsa051330.65127397
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63909447
84Ether lipid metabolism_Homo sapiens_hsa005650.62077576
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61620763
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61604027
87beta-Alanine metabolism_Homo sapiens_hsa004100.61152123
88Sulfur relay system_Homo sapiens_hsa041220.59629758
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58893466
90Apoptosis_Homo sapiens_hsa042100.58514609
91Other glycan degradation_Homo sapiens_hsa005110.58210409
92Phenylalanine metabolism_Homo sapiens_hsa003600.58192020
93Steroid biosynthesis_Homo sapiens_hsa001000.57419873
94Hepatitis B_Homo sapiens_hsa051610.56232520
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55966914
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54029886
97Staphylococcus aureus infection_Homo sapiens_hsa051500.53695342
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53049114
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52897353
100Influenza A_Homo sapiens_hsa051640.52098878
101mRNA surveillance pathway_Homo sapiens_hsa030150.51937555
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50889466
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.50471851
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.49333039
105Tuberculosis_Homo sapiens_hsa051520.49317964
106Alcoholism_Homo sapiens_hsa050340.48074139
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46725201
108Olfactory transduction_Homo sapiens_hsa047400.45648279
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45637666
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.45031293
111Thyroid cancer_Homo sapiens_hsa052160.44289615
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44245835
113Osteoclast differentiation_Homo sapiens_hsa043800.43613553
114Viral carcinogenesis_Homo sapiens_hsa052030.42456762
115Phagosome_Homo sapiens_hsa041450.41013295
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38609172
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38359109
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38087933
119Malaria_Homo sapiens_hsa051440.38030534
120Vibrio cholerae infection_Homo sapiens_hsa051100.37783460
121Galactose metabolism_Homo sapiens_hsa000520.36592057
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36551073
123Retinol metabolism_Homo sapiens_hsa008300.35164321
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34955409
125Rheumatoid arthritis_Homo sapiens_hsa053230.34341215
126HTLV-I infection_Homo sapiens_hsa051660.33507131
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.32424466
128Salmonella infection_Homo sapiens_hsa051320.32049089
129Metabolic pathways_Homo sapiens_hsa011000.29978615
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.29530152
131Folate biosynthesis_Homo sapiens_hsa007900.29387857
132Graft-versus-host disease_Homo sapiens_hsa053320.28456897
133Arachidonic acid metabolism_Homo sapiens_hsa005900.28119971
134T cell receptor signaling pathway_Homo sapiens_hsa046600.26654866
135Platelet activation_Homo sapiens_hsa046110.26363872
136Regulation of autophagy_Homo sapiens_hsa041400.26317883
137Cardiac muscle contraction_Homo sapiens_hsa042600.24477808

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