BAAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.44425769
2L-phenylalanine catabolic process (GO:0006559)7.66721966
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66721966
4epoxygenase P450 pathway (GO:0019373)7.58986896
5L-phenylalanine metabolic process (GO:0006558)7.31530731
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31530731
7omega-hydroxylase P450 pathway (GO:0097267)7.21953307
8aromatic amino acid family catabolic process (GO:0009074)6.96074149
9indole-containing compound catabolic process (GO:0042436)6.34019913
10indolalkylamine catabolic process (GO:0046218)6.34019913
11tryptophan catabolic process (GO:0006569)6.34019913
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.24226814
13kynurenine metabolic process (GO:0070189)6.18328533
14oxidative demethylation (GO:0070989)6.10596984
15drug metabolic process (GO:0017144)6.00126467
16tryptophan metabolic process (GO:0006568)5.95553367
17* bile acid biosynthetic process (GO:0006699)5.90430311
18glyoxylate metabolic process (GO:0046487)5.82414039
19urea metabolic process (GO:0019627)5.77384900
20urea cycle (GO:0000050)5.77384900
21alpha-linolenic acid metabolic process (GO:0036109)5.61687092
22phenylpropanoid metabolic process (GO:0009698)5.61021409
23negative regulation of fibrinolysis (GO:0051918)5.59297708
24complement activation, alternative pathway (GO:0006957)5.53685254
25high-density lipoprotein particle remodeling (GO:0034375)5.47688460
26regulation of protein activation cascade (GO:2000257)5.47269058
27cysteine metabolic process (GO:0006534)5.41464399
28regulation of fibrinolysis (GO:0051917)5.40826674
29protein carboxylation (GO:0018214)5.39565250
30peptidyl-glutamic acid carboxylation (GO:0017187)5.39565250
31sulfur amino acid catabolic process (GO:0000098)5.39431640
32nitrogen cycle metabolic process (GO:0071941)5.30844653
33serine family amino acid catabolic process (GO:0009071)5.17071693
34regulation of plasminogen activation (GO:0010755)5.12751480
35regulation of complement activation (GO:0030449)5.12743765
36aromatic amino acid family metabolic process (GO:0009072)5.05069528
37negative regulation of blood coagulation (GO:0030195)5.03847064
38negative regulation of hemostasis (GO:1900047)5.03847064
39* bile acid metabolic process (GO:0008206)5.03695297
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96786484
41S-adenosylmethionine metabolic process (GO:0046500)4.88815572
42homocysteine metabolic process (GO:0050667)4.88267235
43tyrosine metabolic process (GO:0006570)4.85663002
44regulation of triglyceride catabolic process (GO:0010896)4.83376041
45ethanol metabolic process (GO:0006067)4.76365282
46reverse cholesterol transport (GO:0043691)4.76113578
47regulation of cholesterol esterification (GO:0010872)4.74324997
48daunorubicin metabolic process (GO:0044597)4.73773239
49polyketide metabolic process (GO:0030638)4.73773239
50doxorubicin metabolic process (GO:0044598)4.73773239
51alpha-amino acid catabolic process (GO:1901606)4.70856926
52protein-lipid complex remodeling (GO:0034368)4.69144628
53macromolecular complex remodeling (GO:0034367)4.69144628
54plasma lipoprotein particle remodeling (GO:0034369)4.69144628
55lysine catabolic process (GO:0006554)4.66681419
56lysine metabolic process (GO:0006553)4.66681419
57alkaloid metabolic process (GO:0009820)4.66678334
58amino-acid betaine metabolic process (GO:0006577)4.63192305
59triglyceride homeostasis (GO:0070328)4.61335338
60acylglycerol homeostasis (GO:0055090)4.61335338
61negative regulation of coagulation (GO:0050819)4.59234508
62negative regulation of wound healing (GO:0061045)4.53680046
63negative regulation of sterol transport (GO:0032372)4.51630768
64negative regulation of cholesterol transport (GO:0032375)4.51630768
65coenzyme catabolic process (GO:0009109)4.50675399
66indolalkylamine metabolic process (GO:0006586)4.48859842
67phospholipid efflux (GO:0033700)4.47341596
68imidazole-containing compound metabolic process (GO:0052803)4.43028446
69cellular ketone body metabolic process (GO:0046950)4.41156957
70amine catabolic process (GO:0009310)4.39570033
71cellular biogenic amine catabolic process (GO:0042402)4.39570033
72cellular glucuronidation (GO:0052695)4.34946409
73hormone catabolic process (GO:0042447)4.34924431
74cellular amino acid catabolic process (GO:0009063)4.32613412
75intestinal cholesterol absorption (GO:0030299)4.30975007
76plasma lipoprotein particle clearance (GO:0034381)4.29806665
77glutamate metabolic process (GO:0006536)4.27883934
78positive regulation of hemostasis (GO:1900048)4.26624582
79positive regulation of blood coagulation (GO:0030194)4.26624582
80fat-soluble vitamin biosynthetic process (GO:0042362)4.25064640
81aminoglycoside antibiotic metabolic process (GO:0030647)4.20409522
82ethanol oxidation (GO:0006069)4.18531692
83benzene-containing compound metabolic process (GO:0042537)4.17724788
84* bile acid and bile salt transport (GO:0015721)4.16737441
85cholesterol efflux (GO:0033344)4.15380121
86negative regulation of protein activation cascade (GO:2000258)4.15039616
87acute-phase response (GO:0006953)4.14207877
88* glycine metabolic process (GO:0006544)4.13346718
89flavonoid metabolic process (GO:0009812)4.11013975
90regulation of humoral immune response (GO:0002920)4.08926504
91cellular modified amino acid catabolic process (GO:0042219)4.08177678
92dicarboxylic acid biosynthetic process (GO:0043650)4.07722442
93arginine metabolic process (GO:0006525)4.06659807
94serine family amino acid biosynthetic process (GO:0009070)4.05913916
95* serine family amino acid metabolic process (GO:0009069)4.04162694
96heme transport (GO:0015886)4.03966205
97aldehyde catabolic process (GO:0046185)4.02621602
98fibrinolysis (GO:0042730)4.00414756
99low-density lipoprotein particle remodeling (GO:0034374)3.96289091
100positive regulation of coagulation (GO:0050820)3.94905394
101plasma lipoprotein particle assembly (GO:0034377)3.91727002
102response to mercury ion (GO:0046689)3.90729952
103primary alcohol catabolic process (GO:0034310)3.89982257
104complement activation, classical pathway (GO:0006958)3.88751101
105cytolysis (GO:0019835)3.87933018
106uronic acid metabolic process (GO:0006063)3.86134944
107glucuronate metabolic process (GO:0019585)3.86134944
108drug catabolic process (GO:0042737)3.85269350
109cofactor catabolic process (GO:0051187)3.83926655
110blood coagulation, intrinsic pathway (GO:0007597)3.83871187
111complement activation (GO:0006956)3.83530407
112ketone body metabolic process (GO:1902224)3.81917097
113steroid catabolic process (GO:0006706)3.80044698
114regulation of bile acid biosynthetic process (GO:0070857)3.79419797
115protein activation cascade (GO:0072376)3.78147405
116carboxylic acid catabolic process (GO:0046395)3.77229859
117organic acid catabolic process (GO:0016054)3.77229859
118acetyl-CoA metabolic process (GO:0006084)3.76049012
119positive regulation of lipoprotein lipase activity (GO:0051006)3.73004713
120positive regulation of triglyceride lipase activity (GO:0061365)3.73004713
121very-low-density lipoprotein particle assembly (GO:0034379)3.72995111
122cholesterol homeostasis (GO:0042632)3.71540019
123xenobiotic metabolic process (GO:0006805)3.71187254
124positive regulation of lipid catabolic process (GO:0050996)3.70667324
125phospholipid homeostasis (GO:0055091)3.70563777
126L-methionine salvage (GO:0071267)3.69301641
127L-methionine biosynthetic process (GO:0071265)3.69301641
128amino acid salvage (GO:0043102)3.69301641
129negative regulation of lipase activity (GO:0060192)3.68810207
130short-chain fatty acid metabolic process (GO:0046459)3.65770559
131regulation of cholesterol homeostasis (GO:2000188)3.65586619
132sterol homeostasis (GO:0055092)3.65512301
133regulation of lipoprotein particle clearance (GO:0010984)3.64001148
134NAD biosynthetic process (GO:0009435)3.60335800
135negative regulation of fatty acid biosynthetic process (GO:0045717)3.58975645
136nicotinamide nucleotide biosynthetic process (GO:0019359)3.56494938
137pyridine nucleotide biosynthetic process (GO:0019363)3.56494938
138plasma lipoprotein particle organization (GO:0071827)3.55776747
139drug transmembrane transport (GO:0006855)3.54195536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.41379273
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20976904
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.12414967
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.49599702
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31938064
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11388603
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74932999
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02590272
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02201955
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07857253
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0061953
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95760617
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95182471
14* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58633082
15CLOCK_20551151_ChIP-Seq_293T_Human1.52977936
16* HTT_18923047_ChIP-ChIP_STHdh_Human1.48501401
17GATA1_22025678_ChIP-Seq_K562_Human1.42484856
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39566192
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23831764
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20024795
21* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17963687
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16763932
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.06905919
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02834873
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00271208
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99868465
27NFE2_27457419_Chip-Seq_LIVER_Mouse0.99059365
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98469914
29HNFA_21074721_ChIP-Seq_CACO-2_Human0.96719604
30CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93140717
31SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91420197
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90309771
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90250097
34PHF8_20622853_ChIP-Seq_HELA_Human0.86217748
35EZH2_27294783_Chip-Seq_NPCs_Mouse0.85067796
36AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83379064
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82689133
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81949958
39IRF8_22096565_ChIP-ChIP_GC-B_Human0.81322834
40GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81312191
41RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80010758
42IRF1_19129219_ChIP-ChIP_H3396_Human0.79102454
43TP53_18474530_ChIP-ChIP_U2OS_Human0.78644079
44GATA4_25053715_ChIP-Seq_YYC3_Human0.78571122
45NFYA_21822215_ChIP-Seq_K562_Human0.78196732
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77754093
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77401223
48PIAS1_25552417_ChIP-Seq_VCAP_Human0.77361691
49SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75812879
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75538483
51GATA6_21074721_ChIP-Seq_CACO-2_Human0.75293127
52SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73678649
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73347094
54SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72924257
55SOX2_21211035_ChIP-Seq_LN229_Human0.71691661
56* RARA_24833708_ChIP-Seq_LIVER_Mouse0.71283132
57ZNF263_19887448_ChIP-Seq_K562_Human0.71215104
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71040159
59CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68984636
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67992892
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67831060
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67240163
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67240163
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67091462
65TCF4_18268006_ChIP-ChIP_LS174T_Human0.66971838
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65714941
67CRX_20693478_ChIP-Seq_RETINA_Mouse0.65679847
68ESR2_21235772_ChIP-Seq_MCF-7_Human0.65605723
69IGF1R_20145208_ChIP-Seq_DFB_Human0.65584165
70SOX2_20726797_ChIP-Seq_SW620_Human0.64972179
71SMAD1_18555785_Chip-Seq_ESCs_Mouse0.64074204
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.62492151
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.61965604
74* RARB_24833708_ChIP-Seq_LIVER_Mouse0.61402333
75OCT4_21477851_ChIP-Seq_ESCs_Mouse0.60848361
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.60787484
77ER_23166858_ChIP-Seq_MCF-7_Human0.60764739
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60710363
79OCT4_18555785_Chip-Seq_ESCs_Mouse0.60371197
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.60032594
81RUNX1_27457419_Chip-Seq_LIVER_Mouse0.59408403
82ETV1_20927104_ChIP-Seq_GIST48_Human0.58960471
83ESRRB_18555785_Chip-Seq_ESCs_Mouse0.58722758
84BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58567285
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58115133
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57650413
87CEBPB_22108803_ChIP-Seq_LS180_Human0.57025176
88KLF5_20875108_ChIP-Seq_MESCs_Mouse0.55909370
89EGR1_19032775_ChIP-ChIP_M12_Human0.54600523
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.53826277
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.53535399
92NFYB_21822215_ChIP-Seq_K562_Human0.53333167
93FOXA1_25552417_ChIP-Seq_VCAP_Human0.53223049
94TAF15_26573619_Chip-Seq_HEK293_Human0.53211727
95PU1_27457419_Chip-Seq_LIVER_Mouse0.53091695
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.52948177
97AR_20517297_ChIP-Seq_VCAP_Human0.52231904
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51912862
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51549233
100MYC_19915707_ChIP-ChIP_AK7_Human0.51430837
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50974478
102KLF4_18555785_Chip-Seq_ESCs_Mouse0.50951332
103RBPJ_21746931_ChIP-Seq_IB4_Human0.50145530
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50090158
105LXR_22292898_ChIP-Seq_THP-1_Human0.49890224
106ESET_19884257_ChIP-Seq_ESCs_Mouse0.49659156
107CBP_21632823_ChIP-Seq_H3396_Human0.48885893
108E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.48548760
109STAT1_17558387_ChIP-Seq_HELA_Human0.48182152
110P53_21459846_ChIP-Seq_SAOS-2_Human0.46260293
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45729294
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.44694808
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.43814970
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42786945
115PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42611637
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42338884
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.42072453
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.41715769
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41646872
120TAF2_19829295_ChIP-Seq_ESCs_Human0.41304761
121BCAT_22108803_ChIP-Seq_LS180_Human0.41098859
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.40921860
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39992880
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.38891386
125GATA1_19941826_ChIP-Seq_K562_Human0.38657291
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.38496256
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37910788
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.37707550
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37672488
130GATA2_19941826_ChIP-Seq_K562_Human0.37421963
131GATA6_25053715_ChIP-Seq_YYC3_Human0.37344617
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37327903
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36017363
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.35270372
135* MYC_27129775_Chip-Seq_CORNEA_Mouse0.34627978
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.34038088
137ERG_20517297_ChIP-Seq_VCAP_Human0.33624882
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.33392610
139CDX2_22108803_ChIP-Seq_LS180_Human0.33168264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.34565508
2MP0005360_urolithiasis7.59102529
3MP0005085_abnormal_gallbladder_physiolo6.53183077
4MP0005365_abnormal_bile_salt6.21925593
5MP0008875_abnormal_xenobiotic_pharmacok5.12975327
6MP0003806_abnormal_nucleotide_metabolis4.32698167
7MP0003252_abnormal_bile_duct3.97548363
8MP0010329_abnormal_lipoprotein_level3.56755036
9MP0009840_abnormal_foam_cell3.20183331
10MP0005083_abnormal_biliary_tract3.04919322
11MP0003195_calcinosis2.81531767
12MP0005332_abnormal_amino_acid2.75633549
13MP0001666_abnormal_nutrient_absorption2.61195912
14MP0003191_abnormal_cellular_cholesterol2.23048427
15MP0000609_abnormal_liver_physiology2.15899387
16MP0004019_abnormal_vitamin_homeostasis2.11210051
17MP0002118_abnormal_lipid_homeostasis2.09727186
18MP0003868_abnormal_feces_composition1.98405981
19MP0002138_abnormal_hepatobiliary_system1.96909282
20MP0005319_abnormal_enzyme/_coenzyme1.83406300
21MP0001764_abnormal_homeostasis1.68064592
22MP0009697_abnormal_copulation1.61993181
23MP0005584_abnormal_enzyme/coenzyme_acti1.56405621
24MP0005451_abnormal_body_composition1.40824534
25MP0003011_delayed_dark_adaptation1.35251284
26MP0003186_abnormal_redox_activity1.25616180
27MP0003656_abnormal_erythrocyte_physiolo1.22394567
28MP0009643_abnormal_urine_homeostasis1.21150296
29MP0000598_abnormal_liver_morphology1.17245063
30MP0005647_abnormal_sex_gland1.16590682
31MP0003705_abnormal_hypodermis_morpholog1.14734234
32MP0009764_decreased_sensitivity_to1.05135657
33MP0000604_amyloidosis1.04965049
34MP0009763_increased_sensitivity_to1.01640163
35MP0002254_reproductive_system_inflammat1.00546104
36MP0010368_abnormal_lymphatic_system0.94613074
37MP0001915_intracranial_hemorrhage0.91958114
38MP0005636_abnormal_mineral_homeostasis0.89840829
39MP0008469_abnormal_protein_level0.88490674
40MP0009642_abnormal_blood_homeostasis0.86084745
41MP0005408_hypopigmentation0.85411292
42MP0005187_abnormal_penis_morphology0.81397753
43MP0006036_abnormal_mitochondrial_physio0.81070818
44MP0002132_abnormal_respiratory_system0.80380480
45MP0005376_homeostasis/metabolism_phenot0.79571848
46MP0005670_abnormal_white_adipose0.79464580
47MP0009765_abnormal_xenobiotic_induced0.77910261
48MP0002876_abnormal_thyroid_physiology0.77065236
49MP0002078_abnormal_glucose_homeostasis0.76533066
50MP0005084_abnormal_gallbladder_morpholo0.76384602
51MP0005220_abnormal_exocrine_pancreas0.73754721
52MP0002971_abnormal_brown_adipose0.71029740
53MP0004130_abnormal_muscle_cell0.69040269
54MP0005334_abnormal_fat_pad0.68561673
55MP0005535_abnormal_body_temperature0.67970214
56MP0003690_abnormal_glial_cell0.67593753
57MP0001661_extended_life_span0.66264145
58MP0005266_abnormal_metabolism0.65561561
59MP0009053_abnormal_anal_canal0.64129691
60MP0003879_abnormal_hair_cell0.62320788
61MP0003329_amyloid_beta_deposits0.61741348
62MP0000639_abnormal_adrenal_gland0.59870018
63MP0006035_abnormal_mitochondrial_morpho0.57794551
64MP0005058_abnormal_lysosome_morphology0.56554587
65MP0001756_abnormal_urination0.56361508
66MP0005448_abnormal_energy_balance0.53710624
67MP0005464_abnormal_platelet_physiology0.49913837
68MP0002822_catalepsy0.49350656
69MP0005023_abnormal_wound_healing0.48260775
70MP0004381_abnormal_hair_follicle0.48102203
71MP0005395_other_phenotype0.46977830
72MP0002928_abnormal_bile_duct0.46808260
73MP0003718_maternal_effect0.45758927
74MP0002282_abnormal_trachea_morphology0.45534498
75MP0008874_decreased_physiological_sensi0.45522529
76MP0003638_abnormal_response/metabolism_0.45369037
77MP0008873_increased_physiological_sensi0.44523992
78MP0002136_abnormal_kidney_physiology0.43178073
79MP0003724_increased_susceptibility_to0.42809221
80MP0004782_abnormal_surfactant_physiolog0.41994266
81MP0003436_decreased_susceptibility_to0.41757436
82MP0002837_dystrophic_cardiac_calcinosis0.41087675
83MP0005248_abnormal_Harderian_gland0.40407256
84MP0003953_abnormal_hormone_level0.39609832
85MP0005166_decreased_susceptibility_to0.39579308
86MP0003075_altered_response_to0.39498261
87MP0000579_abnormal_nail_morphology0.38124275
88MP0003959_abnormal_lean_body0.37284813
89MP0009384_cardiac_valve_regurgitation0.36142801
90MP0009672_abnormal_birth_weight0.35978317
91MP0008872_abnormal_physiological_respon0.35765201
92MP0005666_abnormal_adipose_tissue0.35602565
93MP0002796_impaired_skin_barrier0.33225850
94MP0005197_abnormal_uvea_morphology0.32327369
95MP0009785_altered_susceptibility_to0.32140107
96MP0006082_CNS_inflammation0.32118366
97MP0009115_abnormal_fat_cell0.31738078
98MP0000230_abnormal_systemic_arterial0.31596119
99MP0000249_abnormal_blood_vessel0.30416270
100MP0002249_abnormal_larynx_morphology0.30250918
101MP0001243_abnormal_dermal_layer0.30027266
102MP0002970_abnormal_white_adipose0.29614110
103MP0001853_heart_inflammation0.29196961
104MP0002168_other_aberrant_phenotype0.29111630
105MP0004883_abnormal_blood_vessel0.27961262
106MP0001881_abnormal_mammary_gland0.27667118
107MP0000566_synostosis0.26896285
108MP0001845_abnormal_inflammatory_respons0.26831755
109MP0002089_abnormal_postnatal_growth/wei0.25370303
110MP0002060_abnormal_skin_morphology0.24398375
111MP0000920_abnormal_myelination0.23911015
112MP0002090_abnormal_vision0.23749200
113MP0000427_abnormal_hair_cycle0.23471416
114MP0001851_eye_inflammation0.23208634
115MP0005164_abnormal_response_to0.22959297
116MP0010386_abnormal_urinary_bladder0.22394247
117MP0003632_abnormal_nervous_system0.21027059
118MP0004142_abnormal_muscle_tone0.19571064
119MP0000467_abnormal_esophagus_morphology0.17008600
120MP0000371_diluted_coat_color0.16583611
121MP0002697_abnormal_eye_size0.15688027
122MP0002128_abnormal_blood_circulation0.14882302

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.50376648
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47956278
3Deep venous thrombosis (HP:0002625)7.47318781
4Prolonged partial thromboplastin time (HP:0003645)6.64735170
5Hypobetalipoproteinemia (HP:0003563)6.48286098
6* Abnormality of monocarboxylic acid metabolism (HP:0010996)6.32513963
7Xanthomatosis (HP:0000991)6.32044723
8Complement deficiency (HP:0004431)5.65889007
9Hyperlipoproteinemia (HP:0010980)5.61503951
10Joint hemorrhage (HP:0005261)4.80775290
11Hypolipoproteinemia (HP:0010981)4.79531588
12Hyperammonemia (HP:0001987)4.64338893
13Epidermoid cyst (HP:0200040)4.63055213
14Hyperglycinemia (HP:0002154)4.50722512
15Abnormality of the common coagulation pathway (HP:0010990)4.50166686
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39711676
17Abnormality of methionine metabolism (HP:0010901)4.33972470
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.30555113
19Ketosis (HP:0001946)4.25301350
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17820810
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.16231052
22Hypoalphalipoproteinemia (HP:0003233)4.15191449
23Abnormality of complement system (HP:0005339)4.12921687
24Abnormality of serine family amino acid metabolism (HP:0010894)3.93443841
25Abnormality of glycine metabolism (HP:0010895)3.93443841
26Hyperglycinuria (HP:0003108)3.93173264
27Abnormality of pyrimidine metabolism (HP:0004353)3.90273182
28* Fat malabsorption (HP:0002630)3.83346646
29Hypoglycemic coma (HP:0001325)3.82595573
30Abnormality of the intrinsic pathway (HP:0010989)3.81808953
31Conjugated hyperbilirubinemia (HP:0002908)3.80670041
32Hypercholesterolemia (HP:0003124)3.61660043
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40321298
34Hyperbilirubinemia (HP:0002904)3.35659603
35Abnormality of fatty-acid metabolism (HP:0004359)3.34087795
36Osteomalacia (HP:0002749)3.21152550
37Delayed CNS myelination (HP:0002188)3.13405660
38Abnormality of serum amino acid levels (HP:0003112)3.12982678
39Abnormality of nucleobase metabolism (HP:0010932)3.07193891
40Spontaneous abortion (HP:0005268)3.05514975
41Hypochromic microcytic anemia (HP:0004840)2.99960148
42Ketoacidosis (HP:0001993)2.99806265
43Myocardial infarction (HP:0001658)2.99670537
44Hepatocellular carcinoma (HP:0001402)2.99257021
45Skin nodule (HP:0200036)2.86287842
46Systemic lupus erythematosus (HP:0002725)2.82167851
47Reduced antithrombin III activity (HP:0001976)2.80820106
48Metabolic acidosis (HP:0001942)2.74982433
49Abnormality of purine metabolism (HP:0004352)2.65654246
50* Steatorrhea (HP:0002570)2.62242067
51Purpura (HP:0000979)2.62013943
52Lethargy (HP:0001254)2.61808199
53Dicarboxylic aciduria (HP:0003215)2.56399670
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56399670
55Vascular calcification (HP:0004934)2.56034529
56Acanthocytosis (HP:0001927)2.55741798
57Spastic diplegia (HP:0001264)2.51778567
58Recurrent gram-negative bacterial infections (HP:0005420)2.51083944
59Abnormal gallbladder morphology (HP:0012437)2.49167909
60Hyperphosphaturia (HP:0003109)2.49010600
61Hypoglycemic seizures (HP:0002173)2.45229702
62Mitral stenosis (HP:0001718)2.45010118
63Glomerulonephritis (HP:0000099)2.44117330
64Cerebral edema (HP:0002181)2.44112862
65Gout (HP:0001997)2.42590078
66Cholelithiasis (HP:0001081)2.42221660
67Neonatal onset (HP:0003623)2.40962773
68Arthropathy (HP:0003040)2.40790279
69* Rickets (HP:0002748)2.38672051
70Irritability (HP:0000737)2.36401910
71Abnormal gallbladder physiology (HP:0012438)2.35715778
72Cholecystitis (HP:0001082)2.35715778
73Abnormality of urine glucose concentration (HP:0011016)2.34826329
74Glycosuria (HP:0003076)2.34826329
75Fair hair (HP:0002286)2.30912484
76Cardiovascular calcification (HP:0011915)2.26913467
77Amyloidosis (HP:0011034)2.25716520
78Malnutrition (HP:0004395)2.25227483
79Abnormality of the Achilles tendon (HP:0005109)2.20985390
80Gingival bleeding (HP:0000225)2.20329561
81Sensorimotor neuropathy (HP:0007141)2.19784139
82Esophageal varix (HP:0002040)2.17701222
83Bifid scrotum (HP:0000048)2.16423152
84Brushfield spots (HP:0001088)2.14025449
85Pancreatitis (HP:0001733)2.13679715
86Menorrhagia (HP:0000132)2.12115167
87Enlarged kidneys (HP:0000105)2.10404780
88Late onset (HP:0003584)2.09722493
89Thrombophlebitis (HP:0004418)2.07985736
90Vomiting (HP:0002013)2.05999328
91Elevated alkaline phosphatase (HP:0003155)2.04004103
92Abnormality of the gallbladder (HP:0005264)2.03310360
93Opisthotonus (HP:0002179)2.03259174
94Abnormal urine phosphate concentration (HP:0012599)2.00117733
95Generalized aminoaciduria (HP:0002909)1.99083650
96Hyperinsulinemic hypoglycemia (HP:0000825)1.98819565
97Poikilocytosis (HP:0004447)1.98348473
98Hemorrhage of the eye (HP:0011885)1.98176494
99Increased mean platelet volume (HP:0011877)1.93457144
100Abnormal cartilage morphology (HP:0002763)1.89817367
101Neonatal hypoglycemia (HP:0001998)1.89798324
102Abnormality of iron homeostasis (HP:0011031)1.89142241
103Renal cortical cysts (HP:0000803)1.86750905
104Abnormality of transition element cation homeostasis (HP:0011030)1.86225926
105Hypophosphatemic rickets (HP:0004912)1.84047363
106Abnormal enzyme/coenzyme activity (HP:0012379)1.84011155
107Abnormality of alkaline phosphatase activity (HP:0004379)1.83318795
108Elevated hepatic transaminases (HP:0002910)1.82513043
109Joint swelling (HP:0001386)1.82342801
110Status epilepticus (HP:0002133)1.81512135
111Abnormality of proline metabolism (HP:0010907)1.80960389
112Hydroxyprolinuria (HP:0003080)1.80960389
113Alkalosis (HP:0001948)1.80930457
114Increased serum ferritin (HP:0003281)1.78108862
115Abnormal biliary tract physiology (HP:0012439)1.77943617
116Bile duct proliferation (HP:0001408)1.77943617
117Gangrene (HP:0100758)1.75023156
118Hyperglycemia (HP:0003074)1.74232692
119Abnormal platelet volume (HP:0011876)1.73471869
120Nephritis (HP:0000123)1.72710845
121Acute hepatic failure (HP:0006554)1.69515771
122Pulmonary embolism (HP:0002204)1.67219730
123Hypochromic anemia (HP:0001931)1.60910895
124Impaired platelet aggregation (HP:0003540)1.60103737
125Abnormal platelet function (HP:0011869)1.60103737
126Generalized hypopigmentation of hair (HP:0011358)1.58344924
127Epistaxis (HP:0000421)1.56919655
128Retinal atrophy (HP:0001105)1.56915614
129Atrioventricular block (HP:0001678)1.56786348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.12315904
2FGFR44.62207400
3SIK14.52355534
4ERN14.47483565
5TAOK33.16366418
6ERBB43.13970073
7INSRR2.97733609
8MAP2K42.37997818
9MAP3K122.16553744
10PKN22.15371429
11MST1R2.08773257
12PRPF4B1.99740972
13MAPK111.94421305
14FLT31.87461348
15PIK3CG1.82384510
16LATS11.71565295
17TYK21.69538225
18TRIB31.67782199
19NTRK31.58559293
20ABL21.51398238
21DAPK21.49072461
22MAP3K21.49016133
23PTK61.45294093
24FGFR21.44719340
25NEK91.43008822
26MYLK1.41119401
27FRK1.39770524
28EIF2AK11.27099489
29KDR1.24914837
30JAK21.24411506
31MAP3K71.24058067
32PINK11.14732376
33PRKAA21.12110322
34SCYL21.09383179
35ERBB21.07958169
36GRK61.05185144
37TBK11.03741002
38MAP3K141.03234121
39JAK11.03108926
40MAP2K31.01585951
41MAP3K101.01109346
42MAPK40.99439259
43PRKCZ0.94415668
44CSNK1D0.94332458
45NLK0.94293109
46MAPK150.93742168
47PRKG10.92454741
48STK38L0.89503448
49FER0.85411524
50MET0.84209987
51MAP3K30.82411093
52PRKACA0.82228890
53EPHB10.81913580
54MAPK120.81384368
55BCR0.81180409
56CDK60.80007073
57EPHA30.77858134
58PRKACG0.75613025
59CAMK2G0.75537963
60TIE10.74094318
61CAMKK20.72014536
62STK380.70901219
63PRKCB0.70303273
64MAP3K110.69840580
65KSR20.69566641
66DYRK1B0.67837737
67MAP2K60.67247663
68CSK0.66751448
69GSK3A0.66591855
70CAMK1D0.66429716
71PRKAA10.66129192
72MAPKAPK30.65933259
73ZAP700.65496473
74IRAK30.65406246
75SGK30.65163544
76MAPK70.61336236
77RPS6KA30.61234164
78SGK10.59502005
79FGFR30.59023710
80TNK20.58729204
81CSNK1E0.58423665
82CSF1R0.56987290
83RIPK10.56861440
84RPS6KB10.56822252
85PDK20.56811604
86BLK0.54564154
87PRKCQ0.53080880
88IKBKE0.52884484
89PTK20.52816149
90TGFBR20.52358261
91MUSK0.51351768
92CSNK1G10.50932283
93PDPK10.50613337
94PKN10.49601112
95SRC0.49055766
96STK160.49004359
97PRKACB0.48944744
98SGK20.48654091
99EPHA40.47890857
100CASK0.47134790
101ARAF0.47026519
102MAP3K130.45392524
103NEK10.45315576
104IGF1R0.44799363
105PDGFRA0.44677754
106GRK10.44002132
107DAPK30.43736564
108PIM20.43505282
109MAP3K50.43503233
110CSNK2A10.42689826
111WNK30.41940053
112TAOK20.41796999
113RET0.41258731
114PRKCG0.40969863
115MAP2K10.40757696
116CDK40.38608404
117ICK0.38228991
118CSNK2A20.37840843
119CSNK1A10.36618138
120MAP3K60.36331221
121EGFR0.34931406
122MTOR0.34825639
123PBK0.34775973
124SGK2230.33160006
125SGK4940.33160006
126CSNK1G20.31817360
127CAMK40.31717358
128PDK10.30640121
129LATS20.29334082
130IRAK20.28677366
131CSNK1G30.28301458
132IRAK10.27844911
133PIK3CA0.26157840
134PRKCA0.25916707
135MAP3K10.24423485
136ABL10.23286623
137PAK30.22029526
138CAMK1G0.21779411
139PDK30.20937696
140PDK40.20937696

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.50059598
2Nitrogen metabolism_Homo sapiens_hsa009103.62214679
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44540412
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37931435
5Arginine biosynthesis_Homo sapiens_hsa002203.11725280
6Complement and coagulation cascades_Homo sapiens_hsa046102.81429090
7Tryptophan metabolism_Homo sapiens_hsa003802.73752006
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64533560
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58046168
10Fatty acid degradation_Homo sapiens_hsa000712.49913403
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40242830
12* Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36588100
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26488643
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15993994
15Butanoate metabolism_Homo sapiens_hsa006502.15790982
16* Peroxisome_Homo sapiens_hsa041462.04404202
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.96879785
18Chemical carcinogenesis_Homo sapiens_hsa052041.96644294
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94390204
20Propanoate metabolism_Homo sapiens_hsa006401.93311724
21Histidine metabolism_Homo sapiens_hsa003401.92445695
22PPAR signaling pathway_Homo sapiens_hsa033201.86928837
23Caffeine metabolism_Homo sapiens_hsa002321.79768993
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.79572495
25Fatty acid metabolism_Homo sapiens_hsa012121.79516983
26Staphylococcus aureus infection_Homo sapiens_hsa051501.77344191
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77239906
28Retinol metabolism_Homo sapiens_hsa008301.73824435
29beta-Alanine metabolism_Homo sapiens_hsa004101.72053088
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68764381
31Selenocompound metabolism_Homo sapiens_hsa004501.60080576
32Phenylalanine metabolism_Homo sapiens_hsa003601.58810249
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57881486
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52207538
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51896726
36Tyrosine metabolism_Homo sapiens_hsa003501.47597003
37* Bile secretion_Homo sapiens_hsa049761.41380451
38Sulfur metabolism_Homo sapiens_hsa009201.36483540
39Pyruvate metabolism_Homo sapiens_hsa006201.35884910
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.34731546
41Fatty acid elongation_Homo sapiens_hsa000621.33139946
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29614176
43Folate biosynthesis_Homo sapiens_hsa007901.21922780
44Biosynthesis of amino acids_Homo sapiens_hsa012301.21721226
45Steroid biosynthesis_Homo sapiens_hsa001001.21640322
46ABC transporters_Homo sapiens_hsa020101.20904277
47Fat digestion and absorption_Homo sapiens_hsa049751.14494090
48Carbon metabolism_Homo sapiens_hsa012001.12642157
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.01742565
50Vitamin B6 metabolism_Homo sapiens_hsa007501.00651201
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98046049
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97101067
53Arginine and proline metabolism_Homo sapiens_hsa003300.95775820
54Sulfur relay system_Homo sapiens_hsa041220.94714998
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88881703
56Vitamin digestion and absorption_Homo sapiens_hsa049770.83207099
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82894376
58Lysine degradation_Homo sapiens_hsa003100.81595511
59One carbon pool by folate_Homo sapiens_hsa006700.76832388
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69628298
61Glycerolipid metabolism_Homo sapiens_hsa005610.66486610
62Glutathione metabolism_Homo sapiens_hsa004800.65536790
63Pentose phosphate pathway_Homo sapiens_hsa000300.55736194
64Fatty acid biosynthesis_Homo sapiens_hsa000610.53535326
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46550949
66* Metabolic pathways_Homo sapiens_hsa011000.45898337
67* Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45173392
68Prion diseases_Homo sapiens_hsa050200.43625506
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41184138
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24995154
71Galactose metabolism_Homo sapiens_hsa000520.24678105
72Pertussis_Homo sapiens_hsa051330.23956513
73Insulin resistance_Homo sapiens_hsa049310.23039228
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22341686
75Linoleic acid metabolism_Homo sapiens_hsa005910.22110930
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21921310
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20373112
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16213731
79Glucagon signaling pathway_Homo sapiens_hsa049220.10099717
80Other glycan degradation_Homo sapiens_hsa005110.05892452
81AMPK signaling pathway_Homo sapiens_hsa041520.01776169
82Lysosome_Homo sapiens_hsa04142-0.2713978
83Ether lipid metabolism_Homo sapiens_hsa00565-0.2443269
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2365740
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2312277
86Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2250238
87Amoebiasis_Homo sapiens_hsa05146-0.2183704
88Circadian rhythm_Homo sapiens_hsa04710-0.1982762
89Renin-angiotensin system_Homo sapiens_hsa04614-0.1976574
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1896663
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1891079
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1861761
93N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1822990
94Hepatitis C_Homo sapiens_hsa05160-0.1774645
95Type II diabetes mellitus_Homo sapiens_hsa04930-0.1758886
96Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1654881
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1642705
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1507955
99African trypanosomiasis_Homo sapiens_hsa05143-0.1468474
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1233046
101Regulation of autophagy_Homo sapiens_hsa04140-0.1204097
102Sphingolipid metabolism_Homo sapiens_hsa00600-0.1153207
103Mineral absorption_Homo sapiens_hsa04978-0.1080114
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1028549
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0811766
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0808859
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0661048
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0507153
109Serotonergic synapse_Homo sapiens_hsa04726-0.0343266

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