BACE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.42068166
2axon ensheathment in central nervous system (GO:0032291)6.42068166
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.84847361
4fatty acid elongation (GO:0030497)4.55915110
5myelination (GO:0042552)4.40874279
6neuron cell-cell adhesion (GO:0007158)4.37443681
7ensheathment of neurons (GO:0007272)4.34635990
8axon ensheathment (GO:0008366)4.34635990
9presynaptic membrane assembly (GO:0097105)4.20319903
10presynaptic membrane organization (GO:0097090)4.12103536
11long-chain fatty acid biosynthetic process (GO:0042759)4.02150550
12negative regulation of neurotransmitter secretion (GO:0046929)3.94575628
13negative regulation of neurotransmitter transport (GO:0051589)3.66696187
14transmission of nerve impulse (GO:0019226)3.53723892
15cellular potassium ion homeostasis (GO:0030007)3.44637658
16establishment of mitochondrion localization (GO:0051654)3.40105498
17neuronal action potential propagation (GO:0019227)3.37066281
18L-amino acid import (GO:0043092)3.34395470
19apical protein localization (GO:0045176)3.33748981
20neuron recognition (GO:0008038)3.29853372
21cerebral cortex radially oriented cell migration (GO:0021799)3.27460862
22synaptic vesicle exocytosis (GO:0016079)3.24145952
23negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21466412
24axonal fasciculation (GO:0007413)3.20899435
25sodium ion export (GO:0071436)3.19013271
26neuronal ion channel clustering (GO:0045161)3.17980440
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.17155226
28negative regulation of protein localization to cell surface (GO:2000009)3.16058290
29regulation of collateral sprouting (GO:0048670)3.15811655
30locomotory exploration behavior (GO:0035641)3.14326110
31photoreceptor cell differentiation (GO:0046530)3.13777576
32eye photoreceptor cell differentiation (GO:0001754)3.13777576
33oligodendrocyte differentiation (GO:0048709)3.12697730
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12618996
35dendritic spine morphogenesis (GO:0060997)3.12399204
36protein localization to synapse (GO:0035418)3.11442661
37regulation of synaptic vesicle exocytosis (GO:2000300)3.08647359
38vocalization behavior (GO:0071625)3.06984411
39synaptic vesicle maturation (GO:0016188)3.06590206
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.03579002
41glycerophospholipid catabolic process (GO:0046475)3.02854506
42cerebellar granule cell differentiation (GO:0021707)2.98705390
43asymmetric protein localization (GO:0008105)2.97916280
44glutamate secretion (GO:0014047)2.96077514
45limb bud formation (GO:0060174)2.95831311
46cholesterol biosynthetic process (GO:0006695)2.95739832
47myelination in peripheral nervous system (GO:0022011)2.94192766
48peripheral nervous system axon ensheathment (GO:0032292)2.94192766
49negative regulation of axonogenesis (GO:0050771)2.93463514
50dendrite morphogenesis (GO:0048813)2.89833773
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.88503024
52response to redox state (GO:0051775)2.88241411
53substantia nigra development (GO:0021762)2.87148652
54negative regulation of axon extension (GO:0030517)2.84115767
55adult walking behavior (GO:0007628)2.82937225
56gamma-aminobutyric acid transport (GO:0015812)2.81875657
57astrocyte development (GO:0014002)2.79094120
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77160682
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75115728
60ionotropic glutamate receptor signaling pathway (GO:0035235)2.73702445
61synaptic transmission, glutamatergic (GO:0035249)2.72913807
62neuron-neuron synaptic transmission (GO:0007270)2.70908279
63protein heterotrimerization (GO:0070208)2.69538974
64cell communication by electrical coupling (GO:0010644)2.69079634
65regulation of neuronal synaptic plasticity (GO:0048168)2.65963787
66neurotransmitter secretion (GO:0007269)2.65215058
67regulation of axon extension involved in axon guidance (GO:0048841)2.64037057
68layer formation in cerebral cortex (GO:0021819)2.63732577
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63290139
70myelin maintenance (GO:0043217)2.62716177
71positive regulation of action potential (GO:0045760)2.62709075
72neuron remodeling (GO:0016322)2.61319349
73cellular response to epinephrine stimulus (GO:0071872)2.60844922
74peptidyl-tyrosine autophosphorylation (GO:0038083)2.60813027
75amino acid import (GO:0043090)2.60390079
76cell migration in hindbrain (GO:0021535)2.59837748
77regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.59811858
78gamma-aminobutyric acid signaling pathway (GO:0007214)2.59510951
79postsynaptic membrane organization (GO:0001941)2.57882742
80sterol biosynthetic process (GO:0016126)2.57381451
81regulation of synaptic vesicle transport (GO:1902803)2.56838592
82glutamate receptor signaling pathway (GO:0007215)2.55914241
83exploration behavior (GO:0035640)2.52504310
84import into cell (GO:0098657)2.51314007
85central nervous system projection neuron axonogenesis (GO:0021952)2.51092213
86nerve growth factor signaling pathway (GO:0038180)2.50554474
87positive regulation of synapse assembly (GO:0051965)2.50056863
88collagen fibril organization (GO:0030199)2.49985084
89synapse assembly (GO:0007416)2.48439586
90cellular response to monoamine stimulus (GO:0071868)2.48031599
91cellular response to catecholamine stimulus (GO:0071870)2.48031599
92regulation of dendritic spine morphogenesis (GO:0061001)2.47986430
93cerebellar Purkinje cell layer development (GO:0021680)2.47674880
94membrane assembly (GO:0071709)2.47158512
95axon extension (GO:0048675)2.46862100
96response to epinephrine (GO:0071871)2.46790692
97potassium ion homeostasis (GO:0055075)2.46659397
98sequestering of extracellular ligand from receptor (GO:0035581)2.45338772
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44650847
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.44367088
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44070818
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.43417321
103dendrite development (GO:0016358)2.43228434
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.42979122
105response to monoamine (GO:0071867)2.42729378
106response to catecholamine (GO:0071869)2.42729378
107response to gravity (GO:0009629)2.42674269
108long-term synaptic potentiation (GO:0060291)2.42040996
109regulation of dendrite morphogenesis (GO:0048814)2.42004824
110synapse organization (GO:0050808)2.41307055
111cellular sodium ion homeostasis (GO:0006883)2.40093141
112membrane hyperpolarization (GO:0060081)2.39781447
113regulation of axon guidance (GO:1902667)2.38305390
114glycine transport (GO:0015816)2.36488576
115astrocyte differentiation (GO:0048708)2.35087735
116negative regulation of JUN kinase activity (GO:0043508)2.33910145
117regulation of glutamate receptor signaling pathway (GO:1900449)2.33206806
118positive regulation of membrane potential (GO:0045838)2.32983797
119peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.32214705
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.32080372
121neurotransmitter-gated ion channel clustering (GO:0072578)2.31588593
122regulation of neurotransmitter secretion (GO:0046928)2.31584146
123chondrocyte proliferation (GO:0035988)2.31364333
124positive regulation of axon extension (GO:0045773)2.30561705
125negative regulation of hormone biosynthetic process (GO:0032353)2.26456410
126dermatan sulfate biosynthetic process (GO:0030208)2.25577099
127synaptic vesicle endocytosis (GO:0048488)2.25331373
128positive regulation of dendritic spine development (GO:0060999)2.23186589
129detection of calcium ion (GO:0005513)2.23141930
130regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20806446
131kidney mesenchyme development (GO:0072074)2.20314875
132neuromuscular process controlling balance (GO:0050885)2.18744054
133positive regulation of dendrite development (GO:1900006)2.18581982
134extracellular matrix assembly (GO:0085029)2.18154673
135skin morphogenesis (GO:0043589)2.17104584
136positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.15754543
137neuron projection extension (GO:1990138)2.15613126
138regulation of dendritic spine development (GO:0060998)2.14927204
139regulation of synaptic plasticity (GO:0048167)2.14733669
140positive regulation of synapse maturation (GO:0090129)2.14637913
141potassium ion import (GO:0010107)2.13692559
142protein retention in ER lumen (GO:0006621)2.13132258
143chondroitin sulfate catabolic process (GO:0030207)2.12981412
144chemosensory behavior (GO:0007635)2.12743801
145innervation (GO:0060384)2.12548454
146positive regulation of fibroblast migration (GO:0010763)2.11944051
147regulation of synapse structural plasticity (GO:0051823)2.11794803
148dendritic spine organization (GO:0097061)2.11221571
149metanephric mesenchyme development (GO:0072075)2.11144337
150dermatan sulfate metabolic process (GO:0030205)2.10828836
151type B pancreatic cell proliferation (GO:0044342)2.10148596
152suckling behavior (GO:0001967)2.09544031
153auditory behavior (GO:0031223)2.08439844
154regulation of synapse assembly (GO:0051963)2.07716706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92468847
2GBX2_23144817_ChIP-Seq_PC3_Human3.76381006
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.85615944
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79479693
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79042425
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71886415
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.47671014
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45952603
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45952603
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32257530
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31755480
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31375734
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.31112251
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.30774614
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.24071281
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23780296
17TAF15_26573619_Chip-Seq_HEK293_Human2.19555571
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.13152828
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.05748727
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.03965222
21* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.00960058
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96960137
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92265233
24AR_21572438_ChIP-Seq_LNCaP_Human1.91904527
25DROSHA_22980978_ChIP-Seq_HELA_Human1.90310205
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82276118
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82253366
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79290441
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78540227
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75835541
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71897577
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71688461
33REST_21632747_ChIP-Seq_MESCs_Mouse1.70610611
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.65087355
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.61752646
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59983731
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59084709
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58488611
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57094720
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.56720232
41P300_19829295_ChIP-Seq_ESCs_Human1.56498889
42SMAD4_21799915_ChIP-Seq_A2780_Human1.55590412
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51626045
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.51097840
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47282125
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46514611
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44652955
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44142140
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43973047
50ER_23166858_ChIP-Seq_MCF-7_Human1.43022525
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42512207
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39714545
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35951935
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35810914
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.35518869
56VDR_22108803_ChIP-Seq_LS180_Human1.35236892
57FUS_26573619_Chip-Seq_HEK293_Human1.33975157
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31646436
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31356716
60STAT3_23295773_ChIP-Seq_U87_Human1.31287949
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29236718
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28977771
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28949846
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.28240407
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.28002158
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27777909
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23559877
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23437976
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22287249
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.19103532
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19010817
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18369796
73CJUN_26792858_Chip-Seq_BT549_Human1.17296877
74RNF2_27304074_Chip-Seq_NSC_Mouse1.17131629
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15992717
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15630737
77TCF4_23295773_ChIP-Seq_U87_Human1.15271230
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.15097344
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13979820
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.13169981
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.12455265
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10971254
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.10504873
84ZNF274_21170338_ChIP-Seq_K562_Hela1.10484327
85AR_25329375_ChIP-Seq_VCAP_Human1.09991832
86AHR_22903824_ChIP-Seq_MCF-7_Human1.09895265
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.09764062
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09447990
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09447990
90* ESR2_21235772_ChIP-Seq_MCF-7_Human1.09310491
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09176799
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08981884
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08860932
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06143522
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.04502233
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03954601
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03061296
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.02545884
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01972691
100AR_19668381_ChIP-Seq_PC3_Human1.01499332
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01468940
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.01054956
103BRD4_25478319_ChIP-Seq_HGPS_Human1.00769341
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00481939
105KDM2B_26808549_Chip-Seq_K562_Human1.00150201
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.99682102
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.98980402
108TP53_18474530_ChIP-ChIP_U2OS_Human0.98262735
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97860635
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96906149
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96906149
112* SMAD3_21741376_ChIP-Seq_HESCs_Human0.96192750
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95452055
114* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95223067
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95111951
116* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94888511
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94782257
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94317971
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94229946
120IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94083775
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.94028666
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.93778158
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93159460
124CMYC_18555785_Chip-Seq_ESCs_Mouse0.92507825
125TP53_16413492_ChIP-PET_HCT116_Human0.92090611
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92036395
127IGF1R_20145208_ChIP-Seq_DFB_Human0.91859616
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90893393
129TP53_23651856_ChIP-Seq_MEFs_Mouse0.86849481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.20786892
2MP0003880_abnormal_central_pattern3.86000839
3MP0004859_abnormal_synaptic_plasticity3.62617716
4MP0004270_analgesia3.60442108
5* MP0000920_abnormal_myelination2.84955756
6* MP0003635_abnormal_synaptic_transmissio2.70448932
7MP0002272_abnormal_nervous_system2.55780445
8MP0000778_abnormal_nervous_system2.46710522
9MP0001958_emphysema2.45955230
10MP0002064_seizures2.45537136
11MP0009745_abnormal_behavioral_response2.39918242
12MP0001486_abnormal_startle_reflex2.39277168
13MP0002734_abnormal_mechanical_nocicepti2.34360027
14MP0003705_abnormal_hypodermis_morpholog2.29192896
15MP0009046_muscle_twitch2.27649297
16MP0004885_abnormal_endolymph2.23460176
17* MP0002063_abnormal_learning/memory/cond2.14528647
18MP0003279_aneurysm2.02182464
19MP0003283_abnormal_digestive_organ2.01472011
20MP0005423_abnormal_somatic_nervous1.98635226
21* MP0002572_abnormal_emotion/affect_behav1.95291143
22MP0005171_absent_coat_pigmentation1.93891609
23MP0001529_abnormal_vocalization1.93819727
24MP0002735_abnormal_chemical_nociception1.92672639
25MP0004272_abnormal_basement_membrane1.88392308
26MP0005275_abnormal_skin_tensile1.85029296
27MP0004742_abnormal_vestibular_system1.84469097
28MP0001968_abnormal_touch/_nociception1.81192416
29MP0003690_abnormal_glial_cell1.79842975
30MP0001905_abnormal_dopamine_level1.79715834
31MP0005257_abnormal_intraocular_pressure1.73040583
32MP0000955_abnormal_spinal_cord1.69535377
33MP0005409_darkened_coat_color1.66186414
34MP0001984_abnormal_olfaction1.65579520
35MP0003634_abnormal_glial_cell1.62814628
36MP0005551_abnormal_eye_electrophysiolog1.62393809
37MP0001485_abnormal_pinna_reflex1.61211470
38MP0002184_abnormal_innervation1.56583199
39MP0009780_abnormal_chondrocyte_physiolo1.56430097
40* MP0002067_abnormal_sensory_capabilities1.54177816
41MP0010368_abnormal_lymphatic_system1.53868565
42* MP0002882_abnormal_neuron_morphology1.53828806
43MP0001440_abnormal_grooming_behavior1.49075514
44MP0009384_cardiac_valve_regurgitation1.48257070
45MP0008569_lethality_at_weaning1.47536281
46MP0005386_behavior/neurological_phenoty1.47500845
47MP0004924_abnormal_behavior1.47500845
48MP0003950_abnormal_plasma_membrane1.47223792
49MP0006276_abnormal_autonomic_nervous1.46889704
50MP0001299_abnormal_eye_distance/1.46454698
51MP0004142_abnormal_muscle_tone1.45719813
52MP0002736_abnormal_nociception_after1.44662856
53* MP0001970_abnormal_pain_threshold1.42825018
54MP0002822_catalepsy1.41403532
55MP0005646_abnormal_pituitary_gland1.40150590
56MP0002229_neurodegeneration1.39628229
57MP0004134_abnormal_chest_morphology1.38878992
58MP0002909_abnormal_adrenal_gland1.31658829
59* MP0002733_abnormal_thermal_nociception1.30742563
60MP0001177_atelectasis1.29729511
61* MP0002066_abnormal_motor_capabilities/c1.28895659
62MP0001188_hyperpigmentation1.27166703
63MP0002557_abnormal_social/conspecific_i1.26986463
64MP0001502_abnormal_circadian_rhythm1.20337526
65MP0000462_abnormal_digestive_system1.18323955
66MP0002752_abnormal_somatic_nervous1.17786143
67MP0003879_abnormal_hair_cell1.17511529
68MP0005508_abnormal_skeleton_morphology1.17387472
69MP0001963_abnormal_hearing_physiology1.16566715
70MP0003122_maternal_imprinting1.15935069
71MP0000566_synostosis1.15781279
72MP0002837_dystrophic_cardiac_calcinosis1.14999686
73MP0001501_abnormal_sleep_pattern1.13963315
74* MP0003329_amyloid_beta_deposits1.13406421
75MP0004145_abnormal_muscle_electrophysio1.12474425
76MP0002896_abnormal_bone_mineralization1.11712179
77MP0000631_abnormal_neuroendocrine_gland1.11062959
78MP0004811_abnormal_neuron_physiology1.10852925
79MP0002152_abnormal_brain_morphology1.07529940
80* MP0003632_abnormal_nervous_system1.06122080
81MP0004858_abnormal_nervous_system1.04185530
82MP0009250_abnormal_appendicular_skeleto1.01739549
83MP0005595_abnormal_vascular_smooth1.00605550
84MP0003942_abnormal_urinary_system1.00121320
85* MP0003631_nervous_system_phenotype1.00032054
86MP0005623_abnormal_meninges_morphology0.98230175
87MP0003938_abnormal_ear_development0.98132601
88MP0005645_abnormal_hypothalamus_physiol0.97867116
89MP0000569_abnormal_digit_pigmentation0.95024895
90MP0004147_increased_porphyrin_level0.94803777
91MP0006054_spinal_hemorrhage0.94202579
92MP0005499_abnormal_olfactory_system0.93694868
93MP0005394_taste/olfaction_phenotype0.93694868
94MP0002108_abnormal_muscle_morphology0.93382655
95MP0000026_abnormal_inner_ear0.92714811
96MP0010386_abnormal_urinary_bladder0.92697742
97MP0010030_abnormal_orbit_morphology0.92516353
98MP0003787_abnormal_imprinting0.92252133
99MP0003136_yellow_coat_color0.91242791
100MP0000751_myopathy0.89971899
101MP0002090_abnormal_vision0.89859363
102MP0001348_abnormal_lacrimal_gland0.89453721
103* MP0003633_abnormal_nervous_system0.88403998
104MP0000767_abnormal_smooth_muscle0.87138593
105MP0005195_abnormal_posterior_eye0.87118054
106MP0005503_abnormal_tendon_morphology0.86859461
107MP0001346_abnormal_lacrimal_gland0.86848590
108MP0003385_abnormal_body_wall0.86029684
109MP0003566_abnormal_cell_adhesion0.85543013
110MP0000639_abnormal_adrenal_gland0.85029614
111MP0000749_muscle_degeneration0.84381563
112MP0004085_abnormal_heartbeat0.82407373
113MP0003137_abnormal_impulse_conducting0.82009120
114MP0005253_abnormal_eye_physiology0.81965286
115MP0006072_abnormal_retinal_apoptosis0.81824053
116MP0004043_abnormal_pH_regulation0.80709644
117MP0008789_abnormal_olfactory_epithelium0.80210961
118MP0003123_paternal_imprinting0.79942130
119MP0003091_abnormal_cell_migration0.79560316
120MP0002751_abnormal_autonomic_nervous0.79153659
121MP0003937_abnormal_limbs/digits/tail_de0.78171236
122MP0001542_abnormal_bone_strength0.78086505
123MP0000428_abnormal_craniofacial_morphol0.74545368
124MP0000013_abnormal_adipose_tissue0.74217822
125MP0002876_abnormal_thyroid_physiology0.73476474
126MP0003868_abnormal_feces_composition0.73086949
127MP0002938_white_spotting0.72757240
128MP0000534_abnormal_ureter_morphology0.71320071
129MP0000003_abnormal_adipose_tissue0.71296617
130MP0000747_muscle_weakness0.70969938
131MP0002295_abnormal_pulmonary_circulatio0.70895333
132MP0003045_fibrosis0.68756424

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.89978076
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.89978076
3Premature rupture of membranes (HP:0001788)4.87921447
4Protrusio acetabuli (HP:0003179)4.69454664
5Neurofibrillary tangles (HP:0002185)4.25833231
6Abnormality of the corticospinal tract (HP:0002492)4.15807595
7Focal motor seizures (HP:0011153)3.96818812
8Myokymia (HP:0002411)3.72944273
9Sensory axonal neuropathy (HP:0003390)3.49869929
10Atonic seizures (HP:0010819)3.49475938
11Vascular tortuosity (HP:0004948)3.40623589
12Supranuclear gaze palsy (HP:0000605)3.38265834
13Aortic dissection (HP:0002647)3.24874438
14Epileptic encephalopathy (HP:0200134)3.24069304
15Shallow orbits (HP:0000586)3.20363908
16Pheochromocytoma (HP:0002666)3.15173964
17Cerebral inclusion bodies (HP:0100314)3.15170256
18Spastic gait (HP:0002064)3.14502153
19Arterial tortuosity (HP:0005116)3.09874938
20Focal seizures (HP:0007359)3.09228427
21Abnormality of dentin (HP:0010299)3.07676111
22Bladder diverticulum (HP:0000015)3.05893355
23Insidious onset (HP:0003587)3.05222835
24Termporal pattern (HP:0011008)3.05222835
25Aortic aneurysm (HP:0004942)2.98046642
26Broad metatarsal (HP:0001783)2.96104704
27Retinal dysplasia (HP:0007973)2.92874705
28Ankle contracture (HP:0006466)2.89856163
29Dysmetria (HP:0001310)2.85986686
30Bowel diverticulosis (HP:0005222)2.81670239
31Scanning speech (HP:0002168)2.81509653
32Ankle clonus (HP:0011448)2.75694672
33Hyperventilation (HP:0002883)2.74564889
34Soft skin (HP:0000977)2.74519129
35Intention tremor (HP:0002080)2.73682473
36Neuroendocrine neoplasm (HP:0100634)2.73280829
37Hypoventilation (HP:0002791)2.70318308
38Obstructive sleep apnea (HP:0002870)2.70144989
39Peripheral hypomyelination (HP:0007182)2.68434046
40Akinesia (HP:0002304)2.66208251
41Follicular hyperkeratosis (HP:0007502)2.66005739
42Progressive cerebellar ataxia (HP:0002073)2.61186142
43Type 1 muscle fiber predominance (HP:0003803)2.59750655
44Overgrowth (HP:0001548)2.59058031
45Febrile seizures (HP:0002373)2.58992886
46Broad-based gait (HP:0002136)2.54283653
47Neonatal short-limb short stature (HP:0008921)2.54098779
48Action tremor (HP:0002345)2.52718297
49Aplasia involving bones of the extremities (HP:0009825)2.51184821
50Aplasia involving bones of the upper limbs (HP:0009823)2.51184821
51Aplasia of the phalanges of the hand (HP:0009802)2.51184821
52Spinal rigidity (HP:0003306)2.47252469
53Alacrima (HP:0000522)2.46534675
54Cerebral aneurysm (HP:0004944)2.44209557
55Atrophic scars (HP:0001075)2.41862832
56Genu recurvatum (HP:0002816)2.34765072
57Vaginal atresia (HP:0000148)2.33817662
58Thickened helices (HP:0000391)2.32388153
59Wormian bones (HP:0002645)2.32362314
60Genital tract atresia (HP:0001827)2.27931228
61Increased variability in muscle fiber diameter (HP:0003557)2.26784261
62Onion bulb formation (HP:0003383)2.24718770
63Lower limb muscle weakness (HP:0007340)2.24588587
64Dialeptic seizures (HP:0011146)2.23398613
65Dysdiadochokinesis (HP:0002075)2.22264118
66Absence seizures (HP:0002121)2.22147488
67Hyperextensible skin (HP:0000974)2.21957661
68Gait imbalance (HP:0002141)2.21320794
69Cervical subluxation (HP:0003308)2.19380223
70Fetal akinesia sequence (HP:0001989)2.18959891
71Turricephaly (HP:0000262)2.16248104
72Insomnia (HP:0100785)2.15571754
73Gaze-evoked nystagmus (HP:0000640)2.15005961
74Slender build (HP:0001533)2.14771496
75Parakeratosis (HP:0001036)2.14056879
76Megalencephaly (HP:0001355)2.12721331
77Fragile skin (HP:0001030)2.10248192
78Mitral regurgitation (HP:0001653)2.08633235
79Mitral stenosis (HP:0001718)2.07167316
80Cupped ear (HP:0000378)2.07057243
81Mild short stature (HP:0003502)2.06345654
82Blue irides (HP:0000635)2.06308795
83Anteriorly placed anus (HP:0001545)2.05933406
84Wide anterior fontanel (HP:0000260)2.03638410
85Generalized tonic-clonic seizures (HP:0002069)2.02845898
86Visual hallucinations (HP:0002367)2.02201962
87Abnormality of glycolysis (HP:0004366)2.00010909
88Increased serum pyruvate (HP:0003542)2.00010909
89Limb dystonia (HP:0002451)1.96494152
90Coronal craniosynostosis (HP:0004440)1.95335242
91Infantile muscular hypotonia (HP:0008947)1.94077973
92Hemiparesis (HP:0001269)1.92609632
93Upper limb amyotrophy (HP:0009129)1.92017357
94Distal upper limb amyotrophy (HP:0007149)1.92017357
95Mitral valve prolapse (HP:0001634)1.91910473
96Widely spaced teeth (HP:0000687)1.91774011
97Absent speech (HP:0001344)1.90824518
98Humeroradial synostosis (HP:0003041)1.90738840
99Synostosis involving the elbow (HP:0003938)1.90738840
100Slow saccadic eye movements (HP:0000514)1.90123315
101Ulnar bowing (HP:0003031)1.89284043
102Increased circulating renin level (HP:0000848)1.88409089
103Abnormality of incisor morphology (HP:0011063)1.88237508
104Urinary bladder sphincter dysfunction (HP:0002839)1.88125469
105Cerebral hypomyelination (HP:0006808)1.87604869
106Truncal ataxia (HP:0002078)1.87499352
107EEG with generalized epileptiform discharges (HP:0011198)1.87442466
108Medial flaring of the eyebrow (HP:0010747)1.87162316
109Generalized myoclonic seizures (HP:0002123)1.87093695
110Focal dystonia (HP:0004373)1.87050387
111Congenital primary aphakia (HP:0007707)1.86815097
112Mildly elevated creatine phosphokinase (HP:0008180)1.86794433
113Renal duplication (HP:0000075)1.86622681
114Epileptiform EEG discharges (HP:0011182)1.86465100
115Type II lissencephaly (HP:0007260)1.83796711
116Decreased lacrimation (HP:0000633)1.83481216
117Hand muscle atrophy (HP:0009130)1.80823043
118Relative macrocephaly (HP:0004482)1.80815532
119Renovascular hypertension (HP:0100817)1.80226508
120Poor speech (HP:0002465)1.79647469
121Abnormal eating behavior (HP:0100738)1.79128048
122Craniofacial dystonia (HP:0012179)1.78781594
123Drooling (HP:0002307)1.77832339
124Excessive salivation (HP:0003781)1.77832339
125Hypsarrhythmia (HP:0002521)1.76929309
126Central scotoma (HP:0000603)1.76772596
127Joint laxity (HP:0001388)1.76684539
128Mixed hearing impairment (HP:0000410)1.75859822
129Hyperacusis (HP:0010780)1.75511384
130Bell-shaped thorax (HP:0001591)1.75358966
131Bowel incontinence (HP:0002607)1.74797508
132Anxiety (HP:0000739)1.74631524
133Flat cornea (HP:0007720)1.74422070
134Hypoplasia of the iris (HP:0007676)1.74287062
135Blue sclerae (HP:0000592)1.74237857
136Wrist flexion contracture (HP:0001239)1.73689300
137Myelomeningocele (HP:0002475)1.73475565
138Sleep apnea (HP:0010535)1.73069477
139Methylmalonic acidemia (HP:0002912)1.72439055
140Urinary urgency (HP:0000012)1.72249459
141Absent septum pellucidum (HP:0001331)1.72247250
142Buphthalmos (HP:0000557)1.72223935
143Torticollis (HP:0000473)1.71367899
144Nephrogenic diabetes insipidus (HP:0009806)1.70965158
145Dilatation of the ascending aorta (HP:0005111)1.69710795
146Morphological abnormality of the inner ear (HP:0011390)1.69694476
147Cerebral hemorrhage (HP:0001342)1.69106402
148Congenital glaucoma (HP:0001087)1.68960908
149Aqueductal stenosis (HP:0002410)1.68814441
150Abnormality of binocular vision (HP:0011514)1.63698819
151Diplopia (HP:0000651)1.63698819
152Abnormality of skeletal muscle fiber size (HP:0012084)1.63228269
153Leukodystrophy (HP:0002415)1.62963859
154Limited hip movement (HP:0008800)1.62309234
155Overriding aorta (HP:0002623)1.62282799
156Abnormality of the phalanges of the 2nd finger (HP:0009541)1.62226486
157Split foot (HP:0001839)1.61873178
158Clumsiness (HP:0002312)1.61015533
159Steppage gait (HP:0003376)1.60994805
160Osteoarthritis (HP:0002758)1.60490047
161Postural instability (HP:0002172)1.60196001
162Abnormality of the parathyroid morphology (HP:0011766)1.60149772
163Hallux valgus (HP:0001822)1.59217165
164Aneurysm (HP:0002617)1.59027275
165Deviation of the hallux (HP:0010051)1.57556851
166Aortic regurgitation (HP:0001659)1.56275997
167Stridor (HP:0010307)1.56106371
168Hammertoe (HP:0001765)1.52444975
169Macroorchidism (HP:0000053)1.50982938
170Cardiovascular calcification (HP:0011915)1.50091220
171Abnormality of the lower motor neuron (HP:0002366)1.50016200
172Bradycardia (HP:0001662)1.49512848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.29937156
2TNIK3.39962636
3OXSR13.26182490
4PRPF4B2.85468224
5MARK12.62922580
6CASK2.61607158
7EPHA42.57952355
8BCR2.28983990
9PDGFRA2.19442884
10NTRK32.05324998
11LATS22.01718240
12NTRK11.91703779
13FGFR21.88986551
14WNK41.83909007
15PAK61.83557849
16PKN11.80279913
17UHMK11.74747171
18WNK11.73048134
19MAP3K41.70715796
20RIPK11.68393532
21EPHB11.68264983
22MYLK1.67640092
23MAP2K71.66773769
24MAPK131.63598277
25MINK11.56938817
26CDK191.56816552
27SGK2231.52910689
28SGK4941.52910689
29STK381.52374239
30LMTK21.50296176
31PTK21.49352727
32NEK61.48234929
33PNCK1.46454207
34CSNK1A1L1.43670671
35NTRK21.43394826
36CSNK1G31.41460297
37LIMK11.32391310
38CSNK1G21.31193477
39EPHB21.28731455
40PAK31.27826494
41TESK11.25269961
42PAK21.24475598
43PHKG11.24119431
44PHKG21.24119431
45CAMK2B1.22420678
46CDK51.18438353
47MET1.18065271
48CAMK2D1.14165957
49PLK21.11334356
50CSNK1G11.09531969
51PRKD31.09384881
52MAPKAPK51.08606114
53TYRO31.07695368
54MAP3K91.05611755
55LATS11.04271309
56CAMK2A1.00051031
57TRIB30.99544552
58ICK0.94983551
59PRKCE0.92873365
60PRKD20.87924214
61* ROCK20.86581001
62PKN20.84872347
63DYRK20.84868094
64KSR10.82683757
65CAMK10.82429119
66CAMK2G0.82339344
67MAP2K40.82178285
68TTN0.80642627
69STK38L0.78495143
70CDK140.77324208
71MAP3K20.76976169
72DAPK20.74737715
73PDGFRB0.74715227
74FES0.72036589
75PRKCG0.71824383
76CDK180.70720331
77PRKCH0.70534500
78IRAK20.69242986
79PINK10.68317790
80SGK20.68121507
81FGR0.67860951
82CDK150.67553202
83ROCK10.66637294
84CAMK1G0.64728454
85MARK20.63961272
86CAMKK10.62794263
87RPS6KA20.62481466
88KSR20.62056999
89WNK30.60389130
90DYRK1A0.60132566
91FRK0.59874087
92CAMKK20.59017076
93AKT30.58636884
94MAP3K120.57418595
95CDK11A0.55598393
96MAP2K10.55121608
97SIK10.54819479
98PIK3CA0.53373076
99GRK50.53163078
100MUSK0.52936004
101MAPK100.52766522
102CLK10.52612969
103MTOR0.52538405
104ARAF0.52164076
105MAPK120.52009666
106FYN0.51939926
107DDR20.51637169
108SGK10.51568522
109PTK2B0.50706886
110FER0.50589485
111PRKG10.48434703
112PBK0.48200925
113STK110.48119846
114GRK10.45990138
115INSRR0.45755348
116SGK30.45754461
117MOS0.45371617
118DMPK0.45181417
119PDPK10.45085624
120RET0.44117577
121NEK90.44049939
122ERBB40.44043081
123RPS6KA30.43137344
124PRKCQ0.42615775
125TRPM70.41203218
126PRKD10.41194106
127OBSCN0.41160197
128MAPK150.40962598
129BMPR20.40775861
130PRKACA0.40701029
131BMPR1B0.39572225
132CDC42BPA0.39528663

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.23986883
2Steroid biosynthesis_Homo sapiens_hsa001002.57643806
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53297890
4Fatty acid elongation_Homo sapiens_hsa000622.48818010
5Nicotine addiction_Homo sapiens_hsa050332.36651539
6GABAergic synapse_Homo sapiens_hsa047272.22412584
7Glutamatergic synapse_Homo sapiens_hsa047242.12473669
8Axon guidance_Homo sapiens_hsa043602.10499038
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08681556
10Synaptic vesicle cycle_Homo sapiens_hsa047212.04780030
11Circadian entrainment_Homo sapiens_hsa047131.95176447
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88671398
13Serotonergic synapse_Homo sapiens_hsa047261.88105708
14Morphine addiction_Homo sapiens_hsa050321.85038513
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77411329
16Olfactory transduction_Homo sapiens_hsa047401.76607708
17Ether lipid metabolism_Homo sapiens_hsa005651.69411254
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67766215
19Dopaminergic synapse_Homo sapiens_hsa047281.61029210
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60968090
21Long-term depression_Homo sapiens_hsa047301.56557700
22Phototransduction_Homo sapiens_hsa047441.54301671
23Cholinergic synapse_Homo sapiens_hsa047251.53393671
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50972812
25Salivary secretion_Homo sapiens_hsa049701.44532577
26Amphetamine addiction_Homo sapiens_hsa050311.43256571
27Long-term potentiation_Homo sapiens_hsa047201.43177426
28Protein digestion and absorption_Homo sapiens_hsa049741.38742642
29Insulin secretion_Homo sapiens_hsa049111.37547222
30Cocaine addiction_Homo sapiens_hsa050301.37140623
31Taste transduction_Homo sapiens_hsa047421.34680237
32Butanoate metabolism_Homo sapiens_hsa006501.34257135
33Focal adhesion_Homo sapiens_hsa045101.32807324
34Collecting duct acid secretion_Homo sapiens_hsa049661.27749704
35Vibrio cholerae infection_Homo sapiens_hsa051101.24739955
36Renin secretion_Homo sapiens_hsa049241.19461535
37Sulfur metabolism_Homo sapiens_hsa009201.19300942
38Gastric acid secretion_Homo sapiens_hsa049711.17422296
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13134040
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11050628
41Bile secretion_Homo sapiens_hsa049761.10013771
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05929225
43Gap junction_Homo sapiens_hsa045401.05719284
44Hippo signaling pathway_Homo sapiens_hsa043901.03855008
45Oxidative phosphorylation_Homo sapiens_hsa001901.03853306
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02769800
47Oxytocin signaling pathway_Homo sapiens_hsa049211.01765871
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99466326
49ErbB signaling pathway_Homo sapiens_hsa040120.99132808
50Cardiac muscle contraction_Homo sapiens_hsa042600.97775462
51Calcium signaling pathway_Homo sapiens_hsa040200.94534890
52cAMP signaling pathway_Homo sapiens_hsa040240.93249607
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.92507819
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91333489
55Circadian rhythm_Homo sapiens_hsa047100.90013261
56GnRH signaling pathway_Homo sapiens_hsa049120.88901137
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.88737877
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88034141
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87984116
60Renal cell carcinoma_Homo sapiens_hsa052110.87942469
61Sphingolipid metabolism_Homo sapiens_hsa006000.86839697
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85568692
63Prion diseases_Homo sapiens_hsa050200.84786452
64Dilated cardiomyopathy_Homo sapiens_hsa054140.84270577
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.82070801
66Glucagon signaling pathway_Homo sapiens_hsa049220.81776169
67Alzheimers disease_Homo sapiens_hsa050100.81744737
68Ovarian steroidogenesis_Homo sapiens_hsa049130.81498673
69Proteoglycans in cancer_Homo sapiens_hsa052050.80229543
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79928133
71Melanogenesis_Homo sapiens_hsa049160.78298437
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77793459
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.77404011
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76937367
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72442874
76Ras signaling pathway_Homo sapiens_hsa040140.71597251
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71510404
78Pancreatic secretion_Homo sapiens_hsa049720.71117910
79Amoebiasis_Homo sapiens_hsa051460.68875580
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68136150
81Adherens junction_Homo sapiens_hsa045200.68070170
82Parkinsons disease_Homo sapiens_hsa050120.67995354
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67982344
84Basal cell carcinoma_Homo sapiens_hsa052170.67546442
85Tight junction_Homo sapiens_hsa045300.67202067
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66614742
87AMPK signaling pathway_Homo sapiens_hsa041520.65744622
88Protein export_Homo sapiens_hsa030600.64454526
89beta-Alanine metabolism_Homo sapiens_hsa004100.64114690
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63917375
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63908298
92Choline metabolism in cancer_Homo sapiens_hsa052310.62242085
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61621000
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61380660
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.60064910
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60050726
97Melanoma_Homo sapiens_hsa052180.59986404
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59917038
99Fatty acid metabolism_Homo sapiens_hsa012120.59798217
100Estrogen signaling pathway_Homo sapiens_hsa049150.59248017
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.59188625
102Inositol phosphate metabolism_Homo sapiens_hsa005620.57737202
103Dorso-ventral axis formation_Homo sapiens_hsa043200.57474888
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57411916
105Thyroid hormone synthesis_Homo sapiens_hsa049180.56456785
106Endometrial cancer_Homo sapiens_hsa052130.55992813
107Type II diabetes mellitus_Homo sapiens_hsa049300.54855884
108ECM-receptor interaction_Homo sapiens_hsa045120.54256999
109MAPK signaling pathway_Homo sapiens_hsa040100.54139990
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52497292
111Wnt signaling pathway_Homo sapiens_hsa043100.52375180
112TGF-beta signaling pathway_Homo sapiens_hsa043500.51955945
113Glioma_Homo sapiens_hsa052140.51941360
114mTOR signaling pathway_Homo sapiens_hsa041500.51655701
115Vitamin B6 metabolism_Homo sapiens_hsa007500.51546469
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49974367
117Hedgehog signaling pathway_Homo sapiens_hsa043400.49659793
118Arginine biosynthesis_Homo sapiens_hsa002200.49602502
119Lysine degradation_Homo sapiens_hsa003100.46559238
120Endocytosis_Homo sapiens_hsa041440.46134781
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46083279
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44995537
123Linoleic acid metabolism_Homo sapiens_hsa005910.41614666
124Arginine and proline metabolism_Homo sapiens_hsa003300.38417057
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37334270
126Fatty acid biosynthesis_Homo sapiens_hsa000610.36693978
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35073517
128Regulation of autophagy_Homo sapiens_hsa041400.34408249
129Steroid hormone biosynthesis_Homo sapiens_hsa001400.34376068
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.34188705
131Rap1 signaling pathway_Homo sapiens_hsa040150.32983408
132Phagosome_Homo sapiens_hsa041450.32503288
133Rheumatoid arthritis_Homo sapiens_hsa053230.30878790
134Histidine metabolism_Homo sapiens_hsa003400.30067210

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