BACH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.68613163
2positive regulation of gamma-delta T cell activation (GO:0046645)5.37744726
3positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.30772011
4response to peptidoglycan (GO:0032494)5.12029444
5negative regulation of interleukin-12 production (GO:0032695)4.76638207
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.61145408
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.61145408
8modulation by symbiont of host immune response (GO:0052553)4.61145408
9positive regulation by symbiont of host defense response (GO:0052509)4.61145408
10modulation by symbiont of host defense response (GO:0052031)4.61145408
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.61145408
12negative regulation of cell killing (GO:0031342)4.45709435
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.45709435
14detection of external biotic stimulus (GO:0098581)4.38266939
15detection of other organism (GO:0098543)4.36783997
16regulation of interferon-beta biosynthetic process (GO:0045357)4.12206820
17neutrophil mediated immunity (GO:0002446)4.00620531
18detection of biotic stimulus (GO:0009595)3.98051089
19positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.92876316
20regulation of B cell receptor signaling pathway (GO:0050855)3.92011204
21regulation of gamma-delta T cell activation (GO:0046643)3.83857638
22regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.70986244
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.69695635
24detection of bacterium (GO:0016045)3.61695259
25macrophage activation involved in immune response (GO:0002281)3.60029411
26T-helper 1 type immune response (GO:0042088)3.45618627
27regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.44615724
28myeloid leukocyte mediated immunity (GO:0002444)3.41034448
29myeloid cell activation involved in immune response (GO:0002275)3.35681716
30neutrophil activation (GO:0042119)3.29337037
31response to laminar fluid shear stress (GO:0034616)3.28804726
32positive regulation of cellular amide metabolic process (GO:0034250)3.24084718
33granulocyte activation (GO:0036230)3.23345272
34positive regulation of mast cell activation (GO:0033005)3.21243545
35production of molecular mediator involved in inflammatory response (GO:0002532)3.20974179
36negative regulation of T cell mediated immunity (GO:0002710)3.20397252
37respiratory burst (GO:0045730)3.13480611
38germinal center formation (GO:0002467)3.13072558
39positive regulation of p38MAPK cascade (GO:1900745)3.12432793
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10932884
41regulation of mast cell degranulation (GO:0043304)3.09968790
42regulation of gamma-delta T cell differentiation (GO:0045586)3.08899666
43defense response to protozoan (GO:0042832)3.08103794
44positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.08083798
45positive regulation of interferon-alpha production (GO:0032727)3.07701537
46low-density lipoprotein particle clearance (GO:0034383)3.07538877
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07307045
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06392104
49antigen processing and presentation of endogenous antigen (GO:0019883)3.02218491
50regulation of cholesterol storage (GO:0010885)3.02190500
51regulation of T-helper 2 cell differentiation (GO:0045628)3.00679399
52regulation of mast cell activation (GO:0033003)2.99674717
53negative regulation of lymphocyte mediated immunity (GO:0002707)2.98017628
54regulation of interleukin-12 biosynthetic process (GO:0045075)2.97234380
55leukocyte aggregation (GO:0070486)2.97069829
56microglial cell activation (GO:0001774)2.95723233
57regulation of mast cell activation involved in immune response (GO:0033006)2.92981973
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.92873482
59negative regulation of interleukin-17 production (GO:0032700)2.92809514
60regulation of interferon-alpha production (GO:0032647)2.92523476
61positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90547384
62germ cell migration (GO:0008354)2.88160276
63interferon-gamma-mediated signaling pathway (GO:0060333)2.87185374
64response to protozoan (GO:0001562)2.86460152
65negative regulation of erythrocyte differentiation (GO:0045647)2.86440167
66regulation of macrophage cytokine production (GO:0010935)2.84737093
67positive regulation of macrophage cytokine production (GO:0060907)2.84619208
68B cell receptor signaling pathway (GO:0050853)2.81538020
69positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80586332
70cellular response to ethanol (GO:0071361)2.80187155
71type I interferon signaling pathway (GO:0060337)2.80079537
72cellular response to type I interferon (GO:0071357)2.80079537
73response to muramyl dipeptide (GO:0032495)2.78138128
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.77362361
75cell adhesion mediated by integrin (GO:0033627)2.77340906
76response to type I interferon (GO:0034340)2.76689794
77regulation of leukocyte degranulation (GO:0043300)2.74342971
78positive regulation of mast cell activation involved in immune response (GO:0033008)2.74184098
79positive regulation of mast cell degranulation (GO:0043306)2.74184098
80positive regulation of interferon-beta production (GO:0032728)2.73841304
81myeloid leukocyte activation (GO:0002274)2.73635396
82regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72326276
83regulation of tolerance induction (GO:0002643)2.69554039
84negative regulation of lipid storage (GO:0010888)2.63808576
85positive regulation of interleukin-6 production (GO:0032755)2.63724097
86positive regulation of NF-kappaB import into nucleus (GO:0042346)2.62364987
87dendritic cell migration (GO:0036336)2.62169720
88positive regulation of interleukin-1 beta secretion (GO:0050718)2.62161101
89positive regulation of B cell differentiation (GO:0045579)2.61194007
90neutrophil chemotaxis (GO:0030593)2.60989272
91regulation of interleukin-6 biosynthetic process (GO:0045408)2.60190154
92negative regulation of leukocyte mediated immunity (GO:0002704)2.59007648
93positive regulation of type 2 immune response (GO:0002830)2.58892069
94positive regulation of leukocyte degranulation (GO:0043302)2.58443984
95pinocytosis (GO:0006907)2.58260001
96B cell mediated immunity (GO:0019724)2.57997421
97growth hormone receptor signaling pathway (GO:0060396)2.57437323
98plasma lipoprotein particle assembly (GO:0034377)2.56104255
99I-kappaB phosphorylation (GO:0007252)2.56017514
100protein carboxylation (GO:0018214)2.53671411
101peptidyl-glutamic acid carboxylation (GO:0017187)2.53671411
102phospholipid efflux (GO:0033700)2.52911584
103protein-lipid complex assembly (GO:0065005)2.49161562
104regulation of cholesterol homeostasis (GO:2000188)2.49066685
105embryonic process involved in female pregnancy (GO:0060136)2.48907254
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43670705
107response to host immune response (GO:0052572)2.43670705
108regulation of integrin activation (GO:0033623)2.42606409
109plasma lipoprotein particle clearance (GO:0034381)2.42167279
110phospholipid homeostasis (GO:0055091)2.41839391
111positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41756824
112protein localization to endosome (GO:0036010)2.41752923
113cytokine secretion (GO:0050663)2.41287901
114triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40857311
115positive regulation of SMAD protein import into nucleus (GO:0060391)2.40767057
116regulation of SMAD protein import into nucleus (GO:0060390)2.39637713
117intestinal cholesterol absorption (GO:0030299)2.38308604
118macrophage activation (GO:0042116)2.38217024
119response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.36867257
120response to host (GO:0075136)2.36867257
121response to host defenses (GO:0052200)2.36867257
122positive regulation of blood coagulation (GO:0030194)2.36079053
123positive regulation of hemostasis (GO:1900048)2.36079053
124cholesterol efflux (GO:0033344)2.35011252
125negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.34808057
126positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.33999177
127response to lipoprotein particle (GO:0055094)2.33657624
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30599321
129intestinal epithelial cell development (GO:0060576)2.28243978
130regulation of interferon-beta production (GO:0032648)2.27617668
131regulation of interleukin-8 biosynthetic process (GO:0045414)2.26949019
132positive regulation of lipid storage (GO:0010884)2.26678855
133neutrophil activation involved in immune response (GO:0002283)2.26675419
134regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.26531476
135very-low-density lipoprotein particle assembly (GO:0034379)2.24573184
136pathway-restricted SMAD protein phosphorylation (GO:0060389)2.22674509
137immunoglobulin mediated immune response (GO:0016064)2.20389393
138positive regulation of coagulation (GO:0050820)2.19830730
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.18160957
140hemidesmosome assembly (GO:0031581)2.17937321
141apoptotic cell clearance (GO:0043277)2.17383489
142response to arsenic-containing substance (GO:0046685)2.16943792
143serine family amino acid catabolic process (GO:0009071)2.16641484
144regulation of p38MAPK cascade (GO:1900744)2.16449317
145complement activation, alternative pathway (GO:0006957)2.15437270
146cytoplasmic mRNA processing body assembly (GO:0033962)2.14129658
147positive regulation of osteoblast proliferation (GO:0033690)2.13095342
148response to fluid shear stress (GO:0034405)2.12804949
149positive regulation of cholesterol efflux (GO:0010875)2.12710397
150embryonic placenta development (GO:0001892)2.10986359
151positive regulation of sterol transport (GO:0032373)2.10829709
152positive regulation of cholesterol transport (GO:0032376)2.10829709
153fibrinolysis (GO:0042730)2.10595118
154positive regulation of antigen processing and presentation (GO:0002579)2.09554018
155cellular response to growth hormone stimulus (GO:0071378)2.09032503
156cellular response to arsenic-containing substance (GO:0071243)2.07975702
157cellular extravasation (GO:0045123)2.07883278
158lipoprotein metabolic process (GO:0042157)2.07196317
159wound healing, spreading of epidermal cells (GO:0035313)2.06722477
160positive regulation of protein import into nucleus, translocation (GO:0033160)2.06244050
161modification by symbiont of host morphology or physiology (GO:0044003)2.05631412
162cellular response to thyroid hormone stimulus (GO:0097067)2.03625709
163sterol homeostasis (GO:0055092)2.03610613
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.03453897
165cholesterol homeostasis (GO:0042632)2.01558237
166negative regulation of fibrinolysis (GO:0051918)2.01424291
167skin morphogenesis (GO:0043589)2.01005576
168embryonic retina morphogenesis in camera-type eye (GO:0060059)2.00480491
169positive regulation of histone deacetylation (GO:0031065)1.99208305
170mannose metabolic process (GO:0006013)1.98981927
171urea cycle (GO:0000050)1.98921240
172urea metabolic process (GO:0019627)1.98921240
173positive regulation of heterotypic cell-cell adhesion (GO:0034116)1.98912807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.25115899
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.19954129
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.73072781
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.48438969
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.98679343
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.96604664
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94128669
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76426821
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.70853095
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.60756700
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60223894
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.54198798
13CLOCK_20551151_ChIP-Seq_293T_Human2.52725301
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48288335
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44487208
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.44205181
17* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43520681
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43140163
19* LXR_22158963_ChIP-Seq_LIVER_Mouse2.38973410
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.28968497
21* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12196782
22SPI1_23127762_ChIP-Seq_K562_Human2.09530776
23* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08182152
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.02671037
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95762335
26GATA1_22025678_ChIP-Seq_K562_Human1.92715275
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85286484
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84433559
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.82059857
30* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81913338
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76948716
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76673667
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74873036
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.72747927
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68934087
36* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68101941
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67149930
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64601071
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62621991
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62499024
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.61098839
42SCL_19346495_ChIP-Seq_HPC-7_Human1.60547037
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.60339613
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59240036
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.56249280
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.52278161
47* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52067875
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.50397629
49* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50022735
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.48791256
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47171348
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46815309
53* ELK3_25401928_ChIP-Seq_HUVEC_Human1.43670529
54* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.42892989
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.42892989
56GATA3_27048872_Chip-Seq_THYMUS_Human1.42116661
57* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41103949
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39724963
59* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39244629
60ZNF263_19887448_ChIP-Seq_K562_Human1.39075681
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38981760
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.35826710
63MAF_26560356_Chip-Seq_TH1_Human1.35759791
64* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35447559
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.34703396
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.34703396
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.34703396
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33532708
69GATA1_19941826_ChIP-Seq_K562_Human1.32532449
70* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31460167
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27829400
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.27374647
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26658762
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25899971
75GATA3_26560356_Chip-Seq_TH2_Human1.24398407
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24169313
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.23848632
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23724390
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23125204
80RUNX_20019798_ChIP-Seq_JUKART_Human1.22315649
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22086366
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.21415715
83* ATF3_27146783_Chip-Seq_COLON_Human1.21178174
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20290842
85E2F7_22180533_ChIP-Seq_HELA_Human1.19949580
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19798632
87GATA6_25053715_ChIP-Seq_YYC3_Human1.19609582
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19415917
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18125095
90* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17569807
91KDM2B_26808549_Chip-Seq_DND41_Human1.17410496
92UBF1/2_26484160_Chip-Seq_HMECs_Human1.17346817
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15053913
94VDR_21846776_ChIP-Seq_THP-1_Human1.14916900
95* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14479521
96* GATA1_19941827_ChIP-Seq_MEL_Mouse1.14285233
97PU_27001747_Chip-Seq_BMDM_Mouse1.12594753
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11587457
99VDR_24787735_ChIP-Seq_THP-1_Human1.10588742
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10154709
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09686158
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09366473
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.08888088
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07677270
105CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07369958
106* MYC_22102868_ChIP-Seq_BL_Human1.07257906
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06123633
108GATA4_25053715_ChIP-Seq_YYC3_Human1.05863509
109MYB_26560356_Chip-Seq_TH1_Human1.05751914
110VDR_24763502_ChIP-Seq_THP-1_Human1.05224893
111MYB_26560356_Chip-Seq_TH2_Human1.04996158
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04772925
113RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04644767
114* NCOR1_26117541_ChIP-Seq_K562_Human1.04528391
115UTX_26944678_Chip-Seq_JUKART_Human1.04206597
116FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04201160
117CJUN_26792858_Chip-Seq_BT549_Human1.04028707
118AR_21909140_ChIP-Seq_LNCAP_Human1.03982458
119GATA2_19941826_ChIP-Seq_K562_Human1.01561780
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01410057
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01333183
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00136695
123* SPI1_23547873_ChIP-Seq_NB4_Human1.00076038
124FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99941848
125EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99366873
126GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98936114
127RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91101337
128SMRT_27268052_Chip-Seq_Bcells_Human0.90393749
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88007136
130TFEB_21752829_ChIP-Seq_HELA_Human0.87820352
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85181641
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82064574
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82064574
134* TP53_16413492_ChIP-PET_HCT116_Human0.82064488
135* TP63_23658742_ChIP-Seq_EP156T_Human0.78909062
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78040049
137* BRD4_25478319_ChIP-Seq_HGPS_Human0.77458721
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.76580241
139ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76203221
140SALL4_22934838_ChIP-ChIP_CD34+_Human0.74027271
141JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74014789
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73132719
143* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72372959
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72172539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.85105856
2MP0009840_abnormal_foam_cell2.64698778
3MP0003303_peritoneal_inflammation2.63896984
4MP0000569_abnormal_digit_pigmentation2.52630107
5MP0005671_abnormal_response_to2.16129107
6MP0005360_urolithiasis2.13664304
7MP0008260_abnormal_autophagy2.11407471
8MP0003191_abnormal_cellular_cholesterol2.10563996
9MP0010352_gastrointestinal_tract_polyps2.08773474
10MP0002254_reproductive_system_inflammat2.06929481
11MP0009764_decreased_sensitivity_to1.99114956
12MP0003436_decreased_susceptibility_to1.98523773
13MP0003172_abnormal_lysosome_physiology1.92993799
14MP0009278_abnormal_bone_marrow1.86115278
15MP0005076_abnormal_cell_differentiation1.84253551
16MP0003300_gastrointestinal_ulcer1.78602693
17MP0005058_abnormal_lysosome_morphology1.76021101
18MP0006082_CNS_inflammation1.70270074
19MP0004947_skin_inflammation1.68737772
20MP0002139_abnormal_hepatobiliary_system1.67013425
21MP0003566_abnormal_cell_adhesion1.63075141
22MP0003453_abnormal_keratinocyte_physiol1.62547035
23MP0001835_abnormal_antigen_presentation1.58250748
24MP0005085_abnormal_gallbladder_physiolo1.56467034
25MP0002398_abnormal_bone_marrow1.54578739
26MP0000716_abnormal_immune_system1.53405977
27MP0005451_abnormal_body_composition1.52452480
28MP0004185_abnormal_adipocyte_glucose1.52098617
29MP0003763_abnormal_thymus_physiology1.51270788
30MP0004883_abnormal_blood_vessel1.50666004
31MP0005365_abnormal_bile_salt1.47369616
32MP0002419_abnormal_innate_immunity1.45664881
33MP0008438_abnormal_cutaneous_collagen1.45248418
34MP0000858_altered_metastatic_potential1.41730581
35MP0008057_abnormal_DNA_replication1.41459535
36MP0003448_altered_tumor_morphology1.40679144
37MP0005310_abnormal_salivary_gland1.38072596
38MP0009053_abnormal_anal_canal1.38043982
39MP0004510_myositis1.35658137
40MP0003690_abnormal_glial_cell1.34548992
41MP0010234_abnormal_vibrissa_follicle1.34346969
42MP0002796_impaired_skin_barrier1.33985157
43MP0002006_tumorigenesis1.33319849
44MP0003075_altered_response_to1.32856147
45MP0008004_abnormal_stomach_pH1.31098819
46* MP0005164_abnormal_response_to1.30619561
47MP0003724_increased_susceptibility_to1.29339211
48MP0002332_abnormal_exercise_endurance1.28814437
49MP0002452_abnormal_antigen_presenting1.28633203
50MP0000689_abnormal_spleen_morphology1.28591326
51MP0002722_abnormal_immune_system1.28534672
52MP0003252_abnormal_bile_duct1.27653046
53MP0000685_abnormal_immune_system1.26222342
54MP0005464_abnormal_platelet_physiology1.25998426
55MP0001800_abnormal_humoral_immune1.25376099
56MP0010307_abnormal_tumor_latency1.23325343
57MP0005023_abnormal_wound_healing1.22829305
58MP0003183_abnormal_peptide_metabolism1.21718041
59MP0001533_abnormal_skeleton_physiology1.21283840
60MP0005000_abnormal_immune_tolerance1.20253516
61MP0000609_abnormal_liver_physiology1.20057452
62MP0002060_abnormal_skin_morphology1.19394975
63MP0002429_abnormal_blood_cell1.19344741
64MP0000733_abnormal_muscle_development1.19037038
65MP0002138_abnormal_hepatobiliary_system1.18959279
66MP0002009_preneoplasia1.17578636
67MP0000465_gastrointestinal_hemorrhage1.16605097
68MP0010678_abnormal_skin_adnexa1.16226534
69MP0000383_abnormal_hair_follicle1.15083554
70MP0000604_amyloidosis1.13576543
71MP0001216_abnormal_epidermal_layer1.12829112
72MP0005166_decreased_susceptibility_to1.12483679
73MP0005025_abnormal_response_to1.09753021
74MP0001851_eye_inflammation1.09548556
75MP0001790_abnormal_immune_system1.09275333
76MP0005387_immune_system_phenotype1.09275333
77MP0002166_altered_tumor_susceptibility1.07729281
78MP0005397_hematopoietic_system_phenotyp1.06700606
79MP0001545_abnormal_hematopoietic_system1.06700606
80MP0001915_intracranial_hemorrhage1.06039403
81MP0002132_abnormal_respiratory_system1.05735862
82MP0005275_abnormal_skin_tensile1.05700858
83MP0002723_abnormal_immune_serum1.04808743
84MP0010155_abnormal_intestine_physiology1.04547123
85MP0002405_respiratory_system_inflammati1.03184853
86MP0003091_abnormal_cell_migration1.03127084
87MP0002877_abnormal_melanocyte_morpholog1.02596469
88* MP0000767_abnormal_smooth_muscle1.00843675
89MP0002396_abnormal_hematopoietic_system1.00459970
90MP0003656_abnormal_erythrocyte_physiolo1.00179435
91MP0000015_abnormal_ear_pigmentation1.00077440
92MP0005083_abnormal_biliary_tract0.98625396
93MP0003828_pulmonary_edema0.97964083
94MP0010329_abnormal_lipoprotein_level0.97815974
95MP0002148_abnormal_hypersensitivity_rea0.97137916
96MP0001879_abnormal_lymphatic_vessel0.95004572
97MP0005367_renal/urinary_system_phenotyp0.94075398
98MP0000516_abnormal_urinary_system0.94075398
99MP0001666_abnormal_nutrient_absorption0.93278477
100MP0001845_abnormal_inflammatory_respons0.92436893
101MP0009785_altered_susceptibility_to0.92269904
102MP0001819_abnormal_immune_cell0.90250128
103MP0006054_spinal_hemorrhage0.90062190
104MP0000703_abnormal_thymus_morphology0.89978706
105MP0002420_abnormal_adaptive_immunity0.88759846
106MP0002998_abnormal_bone_remodeling0.88661769
107MP0002098_abnormal_vibrissa_morphology0.88310778
108MP0010368_abnormal_lymphatic_system0.88119988
109MP0009333_abnormal_splenocyte_physiolog0.87150313
110MP0009763_increased_sensitivity_to0.87108753
111MP0003567_abnormal_fetal_cardiomyocyte0.86709305
112MP0003941_abnormal_skin_development0.85333820
113MP0001243_abnormal_dermal_layer0.84718073
114MP0008469_abnormal_protein_level0.84524596
115MP0005408_hypopigmentation0.83168259
116MP0005501_abnormal_skin_physiology0.82146740
117MP0003950_abnormal_plasma_membrane0.82039786
118MP0000598_abnormal_liver_morphology0.82004353
119MP0000377_abnormal_hair_follicle0.81963879
120MP0004808_abnormal_hematopoietic_stem0.81898030
121MP0005666_abnormal_adipose_tissue0.80806095
122MP0000343_altered_response_to0.80538365
123MP0002086_abnormal_extraembryonic_tissu0.80341167
124MP0008875_abnormal_xenobiotic_pharmacok0.80050094
125MP0004272_abnormal_basement_membrane0.80011308
126MP0000371_diluted_coat_color0.79989761
127MP0004381_abnormal_hair_follicle0.79740959
128* MP0003221_abnormal_cardiomyocyte_apopto0.79488914
129MP0001849_ear_inflammation0.79281184
130MP0000249_abnormal_blood_vessel0.78487270
131MP0003866_abnormal_defecation0.78399303
132MP0003045_fibrosis0.77267900
133MP0009931_abnormal_skin_appearance0.77040097
134MP0005390_skeleton_phenotype0.76903813
135MP0005167_abnormal_blood-brain_barrier0.76727603
136MP0004782_abnormal_surfactant_physiolog0.76516209
137MP0001853_heart_inflammation0.76287402
138MP0009765_abnormal_xenobiotic_induced0.75480468
139MP0004484_altered_response_of0.72817410
140MP0003795_abnormal_bone_structure0.64645613
141MP0002277_abnormal_respiratory_mucosa0.64255255
142MP0005174_abnormal_tail_pigmentation0.61410729

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)5.21583554
2Retrobulbar optic neuritis (HP:0100654)5.21583554
3Stomatitis (HP:0010280)3.98655154
4Myocardial infarction (HP:0001658)3.91726385
5Keratoconjunctivitis sicca (HP:0001097)3.89646044
6Thick nail (HP:0001805)3.88513857
7Mediastinal lymphadenopathy (HP:0100721)3.83325833
8Gastrointestinal infarctions (HP:0005244)3.67926009
9Systemic lupus erythematosus (HP:0002725)3.62600964
10Keratoconjunctivitis (HP:0001096)3.54719466
11Eczematoid dermatitis (HP:0000976)3.54349962
12T lymphocytopenia (HP:0005403)3.51835765
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.47730400
14Abnormality of T cell number (HP:0011839)3.30456425
15Elevated erythrocyte sedimentation rate (HP:0003565)3.20491164
16Osteolytic defects of the phalanges of the hand (HP:0009771)3.11972088
17Osteolytic defects of the hand bones (HP:0009699)3.11972088
18Hematochezia (HP:0002573)3.10751224
19Vasculitis (HP:0002633)3.07559219
20Complement deficiency (HP:0004431)3.05439668
21Glomerulonephritis (HP:0000099)3.01957689
22Recurrent bacterial skin infections (HP:0005406)3.00149511
23Recurrent abscess formation (HP:0002722)2.92841996
24Recurrent gram-negative bacterial infections (HP:0005420)2.91284343
25Xanthomatosis (HP:0000991)2.90337115
26Hemoptysis (HP:0002105)2.89922598
27Recurrent cutaneous fungal infections (HP:0011370)2.87147102
28Chronic mucocutaneous candidiasis (HP:0002728)2.87147102
29Pulmonary infiltrates (HP:0002113)2.87090357
30Increased cerebral lipofuscin (HP:0011813)2.86078887
31Obstructive lung disease (HP:0006536)2.85512844
32Chronic obstructive pulmonary disease (HP:0006510)2.85512844
33Urticaria (HP:0001025)2.84974853
34Abnormality of complement system (HP:0005339)2.83188961
35Meningitis (HP:0001287)2.80931841
36Pustule (HP:0200039)2.78102774
37Premature rupture of membranes (HP:0001788)2.75055332
38Disinhibition (HP:0000734)2.72572177
39Deep venous thrombosis (HP:0002625)2.68858173
40Encephalitis (HP:0002383)2.67433909
41Gangrene (HP:0100758)2.66925489
42Chest pain (HP:0100749)2.62358527
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.57799097
44Hypoalphalipoproteinemia (HP:0003233)2.51572587
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.48383176
46Cerebral aneurysm (HP:0004944)2.43694288
47Spontaneous hematomas (HP:0007420)2.43046715
48Esophageal varix (HP:0002040)2.40703319
49Episodic fever (HP:0001954)2.37975382
50Papillary thyroid carcinoma (HP:0002895)2.37545381
51Epistaxis (HP:0000421)2.36461464
52Prolonged bleeding time (HP:0003010)2.32099289
53Peritonitis (HP:0002586)2.31005755
54Loss of speech (HP:0002371)2.30102359
55Osteomyelitis (HP:0002754)2.29676293
56Pulmonary embolism (HP:0002204)2.27520965
57Anorexia (HP:0002039)2.25143307
58Abnormality of macrophages (HP:0004311)2.23561730
59Polycythemia (HP:0001901)2.23215003
60Abnormality of the common coagulation pathway (HP:0010990)2.23120290
61Nephritis (HP:0000123)2.21253602
62Alopecia of scalp (HP:0002293)2.19382357
63Autoimmune hemolytic anemia (HP:0001890)2.17149888
64Abnormality of the peritoneum (HP:0002585)2.14680879
65Viral hepatitis (HP:0006562)2.12756878
66Hypolipoproteinemia (HP:0010981)2.12712278
67Intrahepatic cholestasis (HP:0001406)2.11417331
68Joint hemorrhage (HP:0005261)2.10199216
69Mitral valve prolapse (HP:0001634)2.09846534
70Inflammation of the large intestine (HP:0002037)2.09597745
71Slow saccadic eye movements (HP:0000514)2.09431845
72Conjunctival telangiectasia (HP:0000524)2.08097020
73Abnormality of T cells (HP:0002843)2.07724045
74Fatigue (HP:0012378)2.07432707
75Gingivitis (HP:0000230)2.06266869
76Polyneuropathy (HP:0001271)2.06092269
77Glomerulopathy (HP:0100820)2.05870655
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.05371747
79Increased connective tissue (HP:0009025)2.04928717
80Amaurosis fugax (HP:0100576)2.01255181
81Abnormality of the endocardium (HP:0004306)2.00667844
82Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00371237
83Abnormality of the distal phalanges of the toes (HP:0010182)2.00292359
84Colitis (HP:0002583)1.99546936
85Abnormality of the pleura (HP:0002103)1.98970365
86Keratitis (HP:0000491)1.98090704
87Vertigo (HP:0002321)1.97687681
88Orchitis (HP:0100796)1.95519416
89Thoracolumbar scoliosis (HP:0002944)1.95317007
90Tetraparesis (HP:0002273)1.91413440
91Neoplasm of the tracheobronchial system (HP:0100552)1.90313491
92Gastrointestinal inflammation (HP:0004386)1.87720271
93Urethral obstruction (HP:0000796)1.87639268
94Autoimmune thrombocytopenia (HP:0001973)1.87425849
95Spondylolisthesis (HP:0003302)1.86885011
96Vacuolated lymphocytes (HP:0001922)1.86743862
97Hypercholesterolemia (HP:0003124)1.86145658
98Abnormality of lateral ventricle (HP:0030047)1.86090401
99Peripheral demyelination (HP:0011096)1.85526787
100Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85514218
101Dysostosis multiplex (HP:0000943)1.84790175
102Thrombophlebitis (HP:0004418)1.84624853
103Gingival bleeding (HP:0000225)1.82799279
104Granulocytopenia (HP:0001913)1.82363569
105Sepsis (HP:0100806)1.81825024
106Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81714656
107Abnormal platelet function (HP:0011869)1.81628982
108Impaired platelet aggregation (HP:0003540)1.81628982
109Epidermoid cyst (HP:0200040)1.81430599
110Recurrent fungal infections (HP:0002841)1.81074623
111Myositis (HP:0100614)1.80692306
112Subacute progressive viral hepatitis (HP:0006572)1.80532630
113Leukocytosis (HP:0001974)1.79189865
114Disproportionate tall stature (HP:0001519)1.78580645
115Malnutrition (HP:0004395)1.78547039
116Persistence of primary teeth (HP:0006335)1.76579476
117Hypobetalipoproteinemia (HP:0003563)1.74605113
118Recurrent skin infections (HP:0001581)1.72711253
119Periodontitis (HP:0000704)1.72577941
120Axonal loss (HP:0003447)1.72221720
121Hyperglycemia (HP:0003074)1.72129880
122Recurrent pneumonia (HP:0006532)1.71081279
123Bilateral sensorineural hearing impairment (HP:0008619)1.70821167
124Acne (HP:0001061)1.70763839
125Aortic aneurysm (HP:0004942)1.70432643
126Interstitial pulmonary disease (HP:0006530)1.69966856
127Abnormality of the pericardium (HP:0001697)1.69586982
128Shallow orbits (HP:0000586)1.69520485
129Hydroxyprolinuria (HP:0003080)1.68172332
130Abnormality of proline metabolism (HP:0010907)1.68172332
131Increased mean platelet volume (HP:0011877)1.67390803
132Stomach cancer (HP:0012126)1.66511067
133Protrusio acetabuli (HP:0003179)1.65221105
134Prostate neoplasm (HP:0100787)1.63770221
135Short nail (HP:0001799)1.63193942
136Cellulitis (HP:0100658)1.63182239
137Syringomyelia (HP:0003396)1.62748984
138Spinal cord lesions (HP:0100561)1.62748984
139Increased IgE level (HP:0003212)1.62553564
140Abnormal platelet volume (HP:0011876)1.61815381
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.61237189
142Submucous cleft hard palate (HP:0000176)1.60125285
143Arterial tortuosity (HP:0005116)1.59203707
144Amyloidosis (HP:0011034)1.56521179
145Abnormality of liposaccharide metabolism (HP:0010968)1.56193643
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.56193643
147Abnormality of glycolipid metabolism (HP:0010969)1.56193643
148Hyperlipoproteinemia (HP:0010980)1.56085715
149Increased density of long bones (HP:0006392)1.55771805
150Muscle fiber splitting (HP:0003555)1.54590788
151Arterial thrombosis (HP:0004420)1.53490684
152Eosinophilia (HP:0001880)1.52679775
153Congenital, generalized hypertrichosis (HP:0004540)1.52466704
154Prolonged partial thromboplastin time (HP:0003645)1.51639930
155Recurrent viral infections (HP:0004429)1.51144034
156Difficulty climbing stairs (HP:0003551)1.50077539
157Skin nodule (HP:0200036)1.50069963
158Cupped ribs (HP:0000887)1.49866733
159Hepatocellular carcinoma (HP:0001402)1.49759943
160Coarse hair (HP:0002208)1.48732244

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.77591019
2TGFBR23.03441278
3EPHB12.45921696
4PRPF4B2.44513965
5LATS12.41173972
6FGFR42.27813371
7TYK22.18554934
8EPHA32.12648693
9STK102.08453034
10MAP3K102.04827575
11ERN12.01027944
12MAP3K141.98355924
13TRIB31.97553504
14TBK11.93862772
15MAP3K31.87222375
16NUAK11.83227712
17STK31.78121856
18IKBKB1.76767342
19CDK121.75146826
20PTK61.74779766
21MATK1.69902918
22IRAK21.67000266
23MAP3K131.66236738
24CDK61.64430609
25BLK1.58483473
26TAOK31.54083779
27PIK3CG1.52080655
28MAP3K21.51981130
29KSR21.51378998
30TXK1.51241135
31CHUK1.41876508
32RIPK11.40774199
33MST1R1.40340776
34MAP3K11.40153317
35SYK1.38161801
36FES1.38152643
37YES11.37680077
38TTN1.37214108
39PIM11.36730913
40MAP2K31.31495785
41IRAK31.29291028
42BTK1.28725831
43CSK1.27816760
44GSK3A1.24116044
45FGFR31.20869172
46LYN1.13332238
47EPHA21.11784165
48PKN21.11742443
49MAP4K11.10750349
50CAMK1D1.09552307
51DMPK1.09215494
52EPHB21.08577295
53PDGFRB1.08072504
54STK41.07514624
55NEK91.07444816
56ACVR1B1.05996649
57IKBKE1.04413386
58LRRK21.04137472
59PAK41.04002748
60MAP3K61.02471431
61BMX0.99484024
62ITK0.98182882
63KSR10.96913179
64WNK10.96698535
65MOS0.96224559
66TEC0.95536944
67JAK10.94988713
68RPS6KA40.94524433
69CSF1R0.93769726
70EEF2K0.93091549
71MTOR0.91123088
72MET0.90806509
73SGK20.90691561
74RAF10.90039536
75SGK30.89829622
76TAOK20.88436821
77IRAK40.87746902
78PIM20.86050742
79JAK20.85371344
80MELK0.84950898
81NEK20.83135699
82TGFBR10.82628935
83DYRK1B0.81543267
84HCK0.80503779
85FGR0.80002872
86MST40.79027974
87ERBB40.78841541
88PAK20.77668199
89PRKAA20.76711963
90ZAP700.75523969
91CLK10.74982108
92BRD40.74208398
93ALK0.72762256
94KIT0.72641521
95GRK60.71636394
96CDK90.70308173
97MAP2K20.70156985
98MARK20.68725872
99TRPM70.67003558
100PDK10.66348834
101IRAK10.65974180
102MAPK150.65578981
103MAP3K80.63620676
104LATS20.62831932
105PDGFRA0.62823707
106MAP3K50.62798611
107AKT30.61638099
108DYRK30.60109230
109GRK70.59952431
110DDR20.59348375
111CDC42BPA0.58917299
112NEK60.58223268
113MAPK70.58111763
114ABL10.57628713
115EGFR0.56804284
116FRK0.56329492
117MKNK20.54247537
118MARK30.53850864
119FGFR20.53705114
120SIK10.53476939
121CDK40.52622551
122PDPK10.51764505
123JAK30.50642971
124BMPR20.48876850
125EIF2AK20.48459801
126MAP3K110.47994351
127PTK20.47172358
128NLK0.46736697
129RET0.45644535
130MAPKAPK20.45350672
131MAP2K40.44520641
132STK240.44494948
133CAMKK20.44443360
134ERBB20.43824962
135MKNK10.43515258
136LCK0.43367179
137RPS6KA50.42318920
138TAOK10.41969406
139CAMK1G0.41815293
140TNK20.40174995
141PTK2B0.36495081
142FYN0.35647599

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.10883133
2Complement and coagulation cascades_Homo sapiens_hsa046102.17658681
3Graft-versus-host disease_Homo sapiens_hsa053321.82456919
4Osteoclast differentiation_Homo sapiens_hsa043801.77649834
5Caffeine metabolism_Homo sapiens_hsa002321.76597385
6Allograft rejection_Homo sapiens_hsa053301.74390658
7Leishmaniasis_Homo sapiens_hsa051401.74279845
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.66395743
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56179729
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53256081
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47644441
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.46508322
13Autoimmune thyroid disease_Homo sapiens_hsa053201.46286209
14Vitamin B6 metabolism_Homo sapiens_hsa007501.45596861
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.44214302
16Apoptosis_Homo sapiens_hsa042101.42023092
17Malaria_Homo sapiens_hsa051441.40824160
18Toxoplasmosis_Homo sapiens_hsa051451.40605034
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.40112711
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37820625
21Lysosome_Homo sapiens_hsa041421.34200455
22Rheumatoid arthritis_Homo sapiens_hsa053231.33915068
23Small cell lung cancer_Homo sapiens_hsa052221.29664427
24Chronic myeloid leukemia_Homo sapiens_hsa052201.27434254
25Asthma_Homo sapiens_hsa053101.26679475
26Nitrogen metabolism_Homo sapiens_hsa009101.26370591
27Type I diabetes mellitus_Homo sapiens_hsa049401.25358408
28Adherens junction_Homo sapiens_hsa045201.25035735
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24858210
30MicroRNAs in cancer_Homo sapiens_hsa052061.24198665
31Non-small cell lung cancer_Homo sapiens_hsa052231.23941978
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21772307
33Legionellosis_Homo sapiens_hsa051341.20050274
34African trypanosomiasis_Homo sapiens_hsa051431.19713993
35Prolactin signaling pathway_Homo sapiens_hsa049171.17297679
36Vitamin digestion and absorption_Homo sapiens_hsa049771.17037552
37Pertussis_Homo sapiens_hsa051331.16912040
38Arginine biosynthesis_Homo sapiens_hsa002201.14647346
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.10665440
40Measles_Homo sapiens_hsa051621.10258293
41Fat digestion and absorption_Homo sapiens_hsa049751.10009037
42TNF signaling pathway_Homo sapiens_hsa046681.09899471
43Antigen processing and presentation_Homo sapiens_hsa046121.08586421
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.06974538
45Pancreatic cancer_Homo sapiens_hsa052121.06622184
46B cell receptor signaling pathway_Homo sapiens_hsa046621.06071098
47Tuberculosis_Homo sapiens_hsa051521.05902778
48Notch signaling pathway_Homo sapiens_hsa043301.04122754
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02378765
50PPAR signaling pathway_Homo sapiens_hsa033201.00446226
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.98991294
52Hepatitis C_Homo sapiens_hsa051600.98550628
53Amoebiasis_Homo sapiens_hsa051460.98512630
54Proteoglycans in cancer_Homo sapiens_hsa052050.97767971
55Influenza A_Homo sapiens_hsa051640.95418055
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93752174
57Herpes simplex infection_Homo sapiens_hsa051680.92188864
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91762440
59Acute myeloid leukemia_Homo sapiens_hsa052210.91697986
60Steroid biosynthesis_Homo sapiens_hsa001000.90864014
61Viral myocarditis_Homo sapiens_hsa054160.90509406
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90449959
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90218931
64Lysine degradation_Homo sapiens_hsa003100.89265156
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88960800
66TGF-beta signaling pathway_Homo sapiens_hsa043500.88203413
67ABC transporters_Homo sapiens_hsa020100.85985398
68Tryptophan metabolism_Homo sapiens_hsa003800.85976528
69VEGF signaling pathway_Homo sapiens_hsa043700.85812062
70p53 signaling pathway_Homo sapiens_hsa041150.85511098
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85158072
72ECM-receptor interaction_Homo sapiens_hsa045120.84358647
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84235049
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.83597648
75Retinol metabolism_Homo sapiens_hsa008300.83001083
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.81967715
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.81734729
78Renal cell carcinoma_Homo sapiens_hsa052110.81149516
79Insulin resistance_Homo sapiens_hsa049310.80931666
80Focal adhesion_Homo sapiens_hsa045100.80495894
81Endometrial cancer_Homo sapiens_hsa052130.80445682
82Hepatitis B_Homo sapiens_hsa051610.79848631
83Viral carcinogenesis_Homo sapiens_hsa052030.78073256
84HIF-1 signaling pathway_Homo sapiens_hsa040660.77811648
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77768277
86Shigellosis_Homo sapiens_hsa051310.76174363
87Histidine metabolism_Homo sapiens_hsa003400.74562865
88Selenocompound metabolism_Homo sapiens_hsa004500.73959148
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73932369
90Renin-angiotensin system_Homo sapiens_hsa046140.73235749
91mTOR signaling pathway_Homo sapiens_hsa041500.72559538
92Prostate cancer_Homo sapiens_hsa052150.72547778
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72133350
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.70868086
95Dorso-ventral axis formation_Homo sapiens_hsa043200.70685019
96Other glycan degradation_Homo sapiens_hsa005110.70101504
97FoxO signaling pathway_Homo sapiens_hsa040680.70071475
98Primary immunodeficiency_Homo sapiens_hsa053400.68959371
99Hematopoietic cell lineage_Homo sapiens_hsa046400.68522312
100Phagosome_Homo sapiens_hsa041450.67254745
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67016694
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65989560
103Salmonella infection_Homo sapiens_hsa051320.65896262
104Chemokine signaling pathway_Homo sapiens_hsa040620.65499405
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64981078
106ErbB signaling pathway_Homo sapiens_hsa040120.64679250
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64584762
108Type II diabetes mellitus_Homo sapiens_hsa049300.64414670
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64134492
110Platelet activation_Homo sapiens_hsa046110.63661035
111Inositol phosphate metabolism_Homo sapiens_hsa005620.63355922
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63083235
113Fatty acid degradation_Homo sapiens_hsa000710.62934094
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62677342
115Bladder cancer_Homo sapiens_hsa052190.62437055
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61228569
117T cell receptor signaling pathway_Homo sapiens_hsa046600.60986314
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59687688
119Starch and sucrose metabolism_Homo sapiens_hsa005000.59464467
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.58439105
121GnRH signaling pathway_Homo sapiens_hsa049120.58437731
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57610767
123Chemical carcinogenesis_Homo sapiens_hsa052040.56990808
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56763888
125Epstein-Barr virus infection_Homo sapiens_hsa051690.54863912
126Colorectal cancer_Homo sapiens_hsa052100.53345236
127Glioma_Homo sapiens_hsa052140.51652833
128Choline metabolism in cancer_Homo sapiens_hsa052310.51415642
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49572416
130Systemic lupus erythematosus_Homo sapiens_hsa053220.49282623
131MAPK signaling pathway_Homo sapiens_hsa040100.49227368
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48189912
133HTLV-I infection_Homo sapiens_hsa051660.47442241
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44780736
135Endocytosis_Homo sapiens_hsa041440.43556741
136Thyroid cancer_Homo sapiens_hsa052160.39857105
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39740987
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38699109

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