BAD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.98229738
2protein maturation by protein folding (GO:0022417)6.16300464
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.01768111
4DNA deamination (GO:0045006)4.85726628
5sequestering of actin monomers (GO:0042989)4.65753332
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.63590047
7regulation of cellular amino acid metabolic process (GO:0006521)4.54410622
8antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.51618468
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46946097
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41748900
11ATP synthesis coupled proton transport (GO:0015986)4.41748900
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.39628682
13protein retention in ER lumen (GO:0006621)4.28027531
14proteasome assembly (GO:0043248)4.25569617
15guanosine-containing compound biosynthetic process (GO:1901070)4.24075422
16ribosomal small subunit assembly (GO:0000028)4.17178037
17DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.16994174
18positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.10133400
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.07946836
20intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.05607606
21signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.05607606
22signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.05271818
23signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.05271818
24signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.05271818
25negative regulation of release of cytochrome c from mitochondria (GO:0090201)4.04440916
26GTP biosynthetic process (GO:0006183)3.98444020
27negative regulation of ligase activity (GO:0051352)3.96522915
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.96522915
29protein neddylation (GO:0045116)3.94237012
30cytochrome complex assembly (GO:0017004)3.92032295
31protein complex biogenesis (GO:0070271)3.91743553
32maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.90962934
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.88683252
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.88683252
35regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.85348436
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.84548540
37GDP-mannose metabolic process (GO:0019673)3.80756931
38respiratory chain complex IV assembly (GO:0008535)3.78878607
39iron-sulfur cluster assembly (GO:0016226)3.78347498
40metallo-sulfur cluster assembly (GO:0031163)3.78347498
41respiratory electron transport chain (GO:0022904)3.77954388
42termination of RNA polymerase III transcription (GO:0006386)3.76646531
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.76646531
44electron transport chain (GO:0022900)3.74683062
45antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.70799819
46prostaglandin biosynthetic process (GO:0001516)3.70046859
47prostanoid biosynthetic process (GO:0046457)3.70046859
48lipopolysaccharide biosynthetic process (GO:0009103)3.68856642
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64235401
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.61875210
51NADH dehydrogenase complex assembly (GO:0010257)3.61875210
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61875210
53neutrophil activation involved in immune response (GO:0002283)3.60839926
54chaperone-mediated protein transport (GO:0072321)3.59643776
55mitochondrial respiratory chain complex assembly (GO:0033108)3.54886665
56desmosome organization (GO:0002934)3.52667631
57calcium-mediated signaling using intracellular calcium source (GO:0035584)3.51288269
58positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43856366
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43215011
60UV protection (GO:0009650)3.41471391
61nucleoside diphosphate phosphorylation (GO:0006165)3.40797228
627-methylguanosine mRNA capping (GO:0006370)3.40555592
63extracellular fibril organization (GO:0043206)3.38631347
64cotranslational protein targeting to membrane (GO:0006613)3.37160749
65viral transcription (GO:0019083)3.37018125
66UTP biosynthetic process (GO:0006228)3.36794837
67regulation of cellular amine metabolic process (GO:0033238)3.35204234
68protein targeting to ER (GO:0045047)3.34826750
697-methylguanosine RNA capping (GO:0009452)3.34562618
70RNA capping (GO:0036260)3.34562618
71signal peptide processing (GO:0006465)3.32419937
72positive regulation of ligase activity (GO:0051351)3.31709553
73protein localization to endoplasmic reticulum (GO:0070972)3.25576416
74positive regulation of cell cycle arrest (GO:0071158)3.24884817
75base-excision repair, AP site formation (GO:0006285)3.24464834
76regulation of mitochondrial translation (GO:0070129)3.23593418
77nucleobase-containing small molecule interconversion (GO:0015949)3.23242753
78COPI coating of Golgi vesicle (GO:0048205)3.22707634
79Golgi transport vesicle coating (GO:0048200)3.22707634
80cellular copper ion homeostasis (GO:0006878)3.21463682
81amino sugar catabolic process (GO:0046348)3.18671946
82nuclear envelope reassembly (GO:0031468)3.18112734
83mitotic nuclear envelope reassembly (GO:0007084)3.18112734
84translational termination (GO:0006415)3.17338630
85translation (GO:0006412)3.17098350
86cell-substrate junction assembly (GO:0007044)3.14514462
87oxidative phosphorylation (GO:0006119)3.13639500
88establishment of protein localization to endoplasmic reticulum (GO:0072599)3.10191765
89positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.10148738
90GMP metabolic process (GO:0046037)3.09903234
91negative regulation of mitochondrion organization (GO:0010823)3.06659656
92positive regulation of actin filament depolymerization (GO:0030836)3.05981011
93deoxyribose phosphate biosynthetic process (GO:0046385)3.04167434
942-deoxyribonucleotide biosynthetic process (GO:0009265)3.04167434
95pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03423774
96cyclooxygenase pathway (GO:0019371)3.02520308
97ribosomal small subunit biogenesis (GO:0042274)3.01849814
98cullin deneddylation (GO:0010388)2.99748185
99positive regulation of TOR signaling (GO:0032008)2.97239729
100deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96938526
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94819561
102protein targeting to mitochondrion (GO:0006626)2.94609412
103endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.92318228
104protein insertion into membrane (GO:0051205)2.89468625
105establishment of protein localization to mitochondrion (GO:0072655)2.88697409
106positive regulation of pseudopodium assembly (GO:0031274)2.87255328
107translational elongation (GO:0006414)2.86694653
108ribosomal large subunit biogenesis (GO:0042273)2.86316442
109positive regulation of mitochondrial fission (GO:0090141)2.85406796
110lipoxygenase pathway (GO:0019372)2.84908782
111peptidyl-histidine modification (GO:0018202)2.84853724
112protein-cofactor linkage (GO:0018065)2.84289498
113UTP metabolic process (GO:0046051)2.84073568
114lipopolysaccharide metabolic process (GO:0008653)2.83543811
115CTP biosynthetic process (GO:0006241)2.82960291
116CTP metabolic process (GO:0046036)2.82960291
117response to misfolded protein (GO:0051788)2.82413384
118DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82328422
119negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.81976535
120regulation of autophagic vacuole assembly (GO:2000785)2.81682890
121regulation of ubiquitin-protein transferase activity (GO:0051438)2.79941671
122virion assembly (GO:0019068)2.78957435
123protein deneddylation (GO:0000338)2.78458116
124viral life cycle (GO:0019058)2.76803509
125de novo posttranslational protein folding (GO:0051084)2.75562238
126regulation of ligase activity (GO:0051340)2.72643183
127hydrogen peroxide catabolic process (GO:0042744)2.72427172
128deoxyribonucleotide catabolic process (GO:0009264)2.71117298
129barbed-end actin filament capping (GO:0051016)2.70421937
130hydrogen ion transmembrane transport (GO:1902600)2.70228216
131deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69470785
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.68067830
133purine nucleoside triphosphate biosynthetic process (GO:0009145)2.66603242
134cellular protein complex disassembly (GO:0043624)2.66581587
135purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66044929
136mannosylation (GO:0097502)2.65979819
137purine deoxyribonucleotide catabolic process (GO:0009155)2.65372226
138regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.63209211
139fibril organization (GO:0097435)2.60733544
140copper ion homeostasis (GO:0055070)2.59005017
141purine deoxyribonucleotide metabolic process (GO:0009151)2.58634244
142protein localization to endosome (GO:0036010)2.57437086
143pyrimidine nucleotide catabolic process (GO:0006244)2.57345765
144proline biosynthetic process (GO:0006561)2.57190590
145retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56482188
146nucleoside diphosphate biosynthetic process (GO:0009133)2.56073364
147heme biosynthetic process (GO:0006783)2.55184587
148synaptic vesicle exocytosis (GO:0016079)2.54993813
149regulation of vacuole organization (GO:0044088)2.53577742
150establishment of protein localization to mitochondrial membrane (GO:0090151)2.49896024
151viral protein processing (GO:0019082)2.49319923
1522-deoxyribonucleotide metabolic process (GO:0009394)2.48199737
153regulation of pseudopodium assembly (GO:0031272)2.46051285
154regulation of protein targeting to membrane (GO:0090313)2.45263955
155prostanoid metabolic process (GO:0006692)2.42229809
156prostaglandin metabolic process (GO:0006693)2.42229809
157mitochondrial calcium ion homeostasis (GO:0051560)2.41904147
158positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.41848008
159regulation of metalloenzyme activity (GO:0048552)2.38699447
160deoxyribose phosphate catabolic process (GO:0046386)2.37255942
161pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.35357268
162energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.33360582
163ATP hydrolysis coupled proton transport (GO:0015991)2.33360582
164L-serine transport (GO:0015825)2.32355847
165pyrimidine-containing compound salvage (GO:0008655)2.30046633
166pyrimidine nucleoside salvage (GO:0043097)2.30046633
167positive regulation of protein targeting to membrane (GO:0090314)2.29575650
168protein localization to mitochondrion (GO:0070585)2.29519149
169neuronal ion channel clustering (GO:0045161)2.27132110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.60477340
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28048171
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.08466215
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.90398522
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.87665133
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.59994386
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51482081
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.36619006
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.31754378
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.27995964
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.23624171
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94588986
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78363605
14* SRF_21415370_ChIP-Seq_HL-1_Mouse2.71187516
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65004907
16LXR_22292898_ChIP-Seq_THP-1_Human2.50148451
17* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.49385569
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.48527876
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43976923
20* YY1_21170310_ChIP-Seq_MESCs_Mouse2.40562267
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.38617320
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38590651
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.38427701
24MYC_18555785_ChIP-Seq_MESCs_Mouse2.31520213
25DCP1A_22483619_ChIP-Seq_HELA_Human2.24891786
26ZNF263_19887448_ChIP-Seq_K562_Human2.23442033
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11915991
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08997404
29VDR_23849224_ChIP-Seq_CD4+_Human2.07211335
30* ELK3_25401928_ChIP-Seq_HUVEC_Human1.99271449
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98014959
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97607584
33XRN2_22483619_ChIP-Seq_HELA_Human1.94765325
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.90781037
35* GABP_19822575_ChIP-Seq_HepG2_Human1.89815705
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87709959
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.85357445
38P68_20966046_ChIP-Seq_HELA_Human1.83347024
39ELF1_20517297_ChIP-Seq_JURKAT_Human1.75856281
40FOXP3_21729870_ChIP-Seq_TREG_Human1.75566284
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74469062
42* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74347641
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71549062
44RACK7_27058665_Chip-Seq_MCF-7_Human1.71036708
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68333866
46VDR_21846776_ChIP-Seq_THP-1_Human1.65332594
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59672586
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59161691
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58301853
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.57624727
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57590355
52SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53333518
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52397435
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.52222819
55TTF2_22483619_ChIP-Seq_HELA_Human1.51917707
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50381947
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49680384
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.49025641
59HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.48614360
60ELK1_19687146_ChIP-ChIP_HELA_Human1.43446499
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43382099
62BCOR_27268052_Chip-Seq_Bcells_Human1.42944729
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41564146
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41047459
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40116986
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.39394393
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.39242851
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.38787368
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38383292
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37393055
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36976995
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35499470
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.34061351
74CTCF_27219007_Chip-Seq_Bcells_Human1.33503264
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32415996
76* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31991710
77SPI1_23547873_ChIP-Seq_NB4_Human1.31762161
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29414794
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29025643
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28835028
81* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28235281
82* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27594385
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27296145
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26852109
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26762879
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26751586
87SMC4_20622854_ChIP-Seq_HELA_Human1.26619143
88* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25249389
89PHF8_20622854_ChIP-Seq_HELA_Human1.24305614
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22193586
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21841344
92* TP63_22573176_ChIP-Seq_HFKS_Human1.21369315
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21368326
94TP53_22127205_ChIP-Seq_IMR90_Human1.20766055
95CTCF_20526341_ChIP-Seq_ESCs_Human1.20452279
96E2F1_20622854_ChIP-Seq_HELA_Human1.19685617
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17238238
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16120188
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15183204
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15075340
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.14816963
102* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14397767
103ATF3_27146783_Chip-Seq_COLON_Human1.14053075
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13501126
105STAT1_20625510_ChIP-Seq_HELA_Human1.12132146
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10294974
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10230925
108SA1_27219007_Chip-Seq_Bcells_Human1.09366358
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.08504071
110* TET1_21451524_ChIP-Seq_MESCs_Mouse1.07767436
111STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07435115
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06687323
113* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06075816
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05764204
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05289370
116TET1_21490601_ChIP-Seq_MESCs_Mouse1.05207987
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04218335
118YY1_22570637_ChIP-Seq_MALME-3M_Human1.04198708
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03000869
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02543415
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02315867
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01991322
123OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01385123
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01311578
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01204413
126RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00964418
127HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00924816
128CTCF_21964334_Chip-Seq_Bcells_Human1.00274566
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99682591
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98870444
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98645874
132SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98414898
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.98148691
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97781966
135CREB1_26743006_Chip-Seq_LNCaP_Human0.96907603
136BCL6_27268052_Chip-Seq_Bcells_Human0.96791481
137* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96628681
138CTCF_26484167_Chip-Seq_Bcells_Mouse0.95570974
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94916291
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94566683
141MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94120925
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93983315
143* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93115036
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91987370
145MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.91756181
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91232611
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90096078
148GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89334749
149TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88534332
150GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88519286
151TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88082275
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87364357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.31489358
2MP0008260_abnormal_autophagy3.24592172
3MP0001542_abnormal_bone_strength3.05662661
4MP0002148_abnormal_hypersensitivity_rea3.03046135
5MP0003186_abnormal_redox_activity3.00066681
6MP0003806_abnormal_nucleotide_metabolis2.86279043
7MP0001835_abnormal_antigen_presentation2.83841253
8MP0003329_amyloid_beta_deposits2.52339293
9MP0001986_abnormal_taste_sensitivity2.51637588
10MP0005058_abnormal_lysosome_morphology2.50619578
11MP0001849_ear_inflammation2.49882261
12MP0004272_abnormal_basement_membrane2.48535140
13MP0009785_altered_susceptibility_to2.39688759
14MP0002234_abnormal_pharynx_morphology2.38534672
15MP0003693_abnormal_embryo_hatching2.22460026
16MP0003724_increased_susceptibility_to2.17722161
17MP0000372_irregular_coat_pigmentation2.13978003
18MP0003656_abnormal_erythrocyte_physiolo2.11711682
19MP0000467_abnormal_esophagus_morphology2.09972449
20MP0004859_abnormal_synaptic_plasticity2.09010718
21MP0009333_abnormal_splenocyte_physiolog2.03174040
22MP0009379_abnormal_foot_pigmentation2.02339767
23MP0005451_abnormal_body_composition2.02292778
24MP0004858_abnormal_nervous_system2.01348092
25MP0009840_abnormal_foam_cell2.00806322
26MP0000762_abnormal_tongue_morphology1.96343724
27MP0009053_abnormal_anal_canal1.94794285
28MP0002060_abnormal_skin_morphology1.93483425
29MP0003436_decreased_susceptibility_to1.90928865
30MP0002736_abnormal_nociception_after1.90377599
31MP0002653_abnormal_ependyma_morphology1.89347765
32MP0006036_abnormal_mitochondrial_physio1.80370246
33MP0005083_abnormal_biliary_tract1.80368695
34MP0008438_abnormal_cutaneous_collagen1.80229299
35MP0005257_abnormal_intraocular_pressure1.76960043
36MP0002822_catalepsy1.74693311
37MP0003075_altered_response_to1.72449662
38MP0002132_abnormal_respiratory_system1.71772463
39MP0005025_abnormal_response_to1.70125001
40MP0000678_abnormal_parathyroid_gland1.68868848
41MP0002419_abnormal_innate_immunity1.68788147
42MP0005360_urolithiasis1.68301720
43MP0005084_abnormal_gallbladder_morpholo1.67382444
44MP0005000_abnormal_immune_tolerance1.66628098
45MP0003566_abnormal_cell_adhesion1.66295713
46MP0003191_abnormal_cellular_cholesterol1.66146856
47MP0005501_abnormal_skin_physiology1.65994735
48MP0001984_abnormal_olfaction1.65199994
49MP0006082_CNS_inflammation1.64392757
50MP0001905_abnormal_dopamine_level1.61925395
51MP0004883_abnormal_blood_vessel1.61602380
52MP0000015_abnormal_ear_pigmentation1.61498374
53MP0005670_abnormal_white_adipose1.60183395
54MP0001764_abnormal_homeostasis1.60086873
55MP0005623_abnormal_meninges_morphology1.60041169
56MP0009697_abnormal_copulation1.58993605
57MP0000537_abnormal_urethra_morphology1.58039549
58MP0010771_integument_phenotype1.55131687
59MP0000343_altered_response_to1.52332986
60MP0005464_abnormal_platelet_physiology1.51963012
61MP0003705_abnormal_hypodermis_morpholog1.48207293
62MP0000751_myopathy1.48084884
63MP0006054_spinal_hemorrhage1.47041240
64MP0003718_maternal_effect1.47006574
65MP0000750_abnormal_muscle_regeneration1.46219980
66MP0010030_abnormal_orbit_morphology1.46031151
67MP0005165_increased_susceptibility_to1.46002424
68MP0010386_abnormal_urinary_bladder1.45896883
69MP0001216_abnormal_epidermal_layer1.44134699
70MP0001853_heart_inflammation1.43975110
71MP0006035_abnormal_mitochondrial_morpho1.42814675
72MP0000685_abnormal_immune_system1.39755025
73MP0005164_abnormal_response_to1.38229221
74MP0001968_abnormal_touch/_nociception1.34350647
75MP0001533_abnormal_skeleton_physiology1.34158430
76MP0005671_abnormal_response_to1.32757523
77MP0002163_abnormal_gland_morphology1.32591220
78MP0008875_abnormal_xenobiotic_pharmacok1.32489530
79MP0005409_darkened_coat_color1.32266944
80MP0006276_abnormal_autonomic_nervous1.30846784
81MP0002876_abnormal_thyroid_physiology1.30743982
82MP0008469_abnormal_protein_level1.28639486
83MP0002735_abnormal_chemical_nociception1.27862030
84MP0001756_abnormal_urination1.27427288
85* MP0002160_abnormal_reproductive_system1.27409356
86MP0005394_taste/olfaction_phenotype1.25170394
87MP0005499_abnormal_olfactory_system1.25170394
88MP0003136_yellow_coat_color1.24700229
89MP0000358_abnormal_cell_content/1.23613433
90MP0000858_altered_metastatic_potential1.20403819
91MP0003878_abnormal_ear_physiology1.20245180
92MP0005377_hearing/vestibular/ear_phenot1.20245180
93MP0004782_abnormal_surfactant_physiolog1.19029457
94MP0000490_abnormal_crypts_of1.16924671
95MP0005408_hypopigmentation1.16662463
96MP0003879_abnormal_hair_cell1.16243216
97* MP0002452_abnormal_antigen_presenting1.15691880
98MP0001845_abnormal_inflammatory_respons1.14047836
99MP0005330_cardiomyopathy1.11294726
100MP0005423_abnormal_somatic_nervous1.10350139
101MP0002723_abnormal_immune_serum1.10293426
102MP0008789_abnormal_olfactory_epithelium1.09652712
103MP0003123_paternal_imprinting1.09165069
104* MP0001819_abnormal_immune_cell1.06969115
105MP0005636_abnormal_mineral_homeostasis1.06730223
106MP0000604_amyloidosis1.06340081
107MP0002796_impaired_skin_barrier1.06095477
108MP0005503_abnormal_tendon_morphology1.05560061
109MP0003453_abnormal_keratinocyte_physiol1.05037107
110MP0008874_decreased_physiological_sensi1.04507289
111MP0005171_absent_coat_pigmentation1.04013373
112* MP0002420_abnormal_adaptive_immunity1.03710758
113MP0003011_delayed_dark_adaptation1.03082719
114MP0005023_abnormal_wound_healing1.02653425
115MP0003866_abnormal_defecation1.02580064
116MP0005275_abnormal_skin_tensile1.01764042
117MP0005410_abnormal_fertilization1.01138471
118MP0002638_abnormal_pupillary_reflex0.98496738
119MP0009764_decreased_sensitivity_to0.97918156
120MP0004147_increased_porphyrin_level0.97390908
121MP0000681_abnormal_thyroid_gland0.97342154
122MP0002751_abnormal_autonomic_nervous0.96572339
123MP0005332_abnormal_amino_acid0.95373101
124MP0002295_abnormal_pulmonary_circulatio0.95034378
125MP0002909_abnormal_adrenal_gland0.91429310
126MP0005376_homeostasis/metabolism_phenot0.90717586
127MP0001727_abnormal_embryo_implantation0.90610193
128MP0002405_respiratory_system_inflammati0.90456443
129MP0003880_abnormal_central_pattern0.90337177
130MP0009643_abnormal_urine_homeostasis0.90107357
131MP0003638_abnormal_response/metabolism_0.89697755
132MP0001958_emphysema0.88978843
133MP0002098_abnormal_vibrissa_morphology0.88932651
134MP0004510_myositis0.88702399
135MP0000538_abnormal_urinary_bladder0.88453602
136MP0002733_abnormal_thermal_nociception0.87902144
137MP0003635_abnormal_synaptic_transmissio0.87269052
138MP0000013_abnormal_adipose_tissue0.85134495
139MP0005390_skeleton_phenotype0.83871321
140MP0003279_aneurysm0.82954926
141MP0010368_abnormal_lymphatic_system0.82446900
142MP0008932_abnormal_embryonic_tissue0.81157190
143MP0001970_abnormal_pain_threshold0.81134678
144MP0005584_abnormal_enzyme/coenzyme_acti0.80737219
145MP0000003_abnormal_adipose_tissue0.80672264
146MP0002332_abnormal_exercise_endurance0.76284071
147MP0001529_abnormal_vocalization0.74844323
148MP0004270_analgesia0.74720504
149MP0004019_abnormal_vitamin_homeostasis0.74714414
150MP0003315_abnormal_perineum_morphology0.73779780
151MP0009780_abnormal_chondrocyte_physiolo0.73749863
152MP0001790_abnormal_immune_system0.73038920
153MP0005387_immune_system_phenotype0.73038920
154MP0002277_abnormal_respiratory_mucosa0.72325122
155MP0009278_abnormal_bone_marrow0.72258891
156* MP0003634_abnormal_glial_cell0.71826543
157MP0009931_abnormal_skin_appearance0.71779892
158MP0005319_abnormal_enzyme/_coenzyme0.71368621
159MP0003195_calcinosis0.71221916
160MP0002998_abnormal_bone_remodeling0.69689459
161MP0002734_abnormal_mechanical_nocicepti0.68563950
162MP0002572_abnormal_emotion/affect_behav0.66201500
163MP0005193_abnormal_anterior_eye0.66081652
164MP0002064_seizures0.64498482
165MP0002272_abnormal_nervous_system0.63052672

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)5.95311332
2Onycholysis (HP:0001806)5.86508864
3Atrophic scars (HP:0001075)5.50853152
4Acute necrotizing encephalopathy (HP:0006965)4.80553255
5Milia (HP:0001056)4.72192976
6Mitochondrial inheritance (HP:0001427)4.70542801
7Hepatocellular necrosis (HP:0001404)4.62748804
8Abnormal mitochondria in muscle tissue (HP:0008316)4.27714116
9Hepatic necrosis (HP:0002605)4.23553597
10Increased CSF lactate (HP:0002490)4.03784375
11Acute encephalopathy (HP:0006846)3.80577812
12Progressive macrocephaly (HP:0004481)3.77731555
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.76907336
14Increased hepatocellular lipid droplets (HP:0006565)3.73395585
15Plantar hyperkeratosis (HP:0007556)3.64842071
16Nail dystrophy (HP:0008404)3.61474027
17Lipid accumulation in hepatocytes (HP:0006561)3.51775988
18Renal Fanconi syndrome (HP:0001994)3.43837722
19Vacuolated lymphocytes (HP:0001922)3.34048358
20Exertional dyspnea (HP:0002875)3.30170206
21Petechiae (HP:0000967)3.27676791
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.26532187
23Abnormality of cells of the erythroid lineage (HP:0012130)3.17366690
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17032050
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17032050
26Myokymia (HP:0002411)3.16477132
27Alopecia of scalp (HP:0002293)3.05390320
28Elevated erythrocyte sedimentation rate (HP:0003565)2.96465556
29Type I transferrin isoform profile (HP:0003642)2.91538338
30Respiratory failure (HP:0002878)2.88203597
31Recurrent abscess formation (HP:0002722)2.87657849
32Abnormal number of erythroid precursors (HP:0012131)2.87476729
33Hypothermia (HP:0002045)2.85888807
34Increased serum lactate (HP:0002151)2.85832323
35Poor head control (HP:0002421)2.79222217
363-Methylglutaconic aciduria (HP:0003535)2.78952322
37Exercise intolerance (HP:0003546)2.76447872
38Recurrent bacterial skin infections (HP:0005406)2.76158355
39Increased intramyocellular lipid droplets (HP:0012240)2.76022971
40Lactic acidosis (HP:0003128)2.75866902
41Distal lower limb muscle weakness (HP:0009053)2.75341097
42Testicular atrophy (HP:0000029)2.69930169
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.64420311
44Hand muscle atrophy (HP:0009130)2.62229359
45Abnormality of nail color (HP:0100643)2.61806275
46Vertebral compression fractures (HP:0002953)2.60402926
47Pili torti (HP:0003777)2.59881826
48Abnormal blistering of the skin (HP:0008066)2.56069313
49Abnormality of macrophages (HP:0004311)2.53215355
50Achilles tendon contracture (HP:0001771)2.52688791
51Purpura (HP:0000979)2.52581614
52Distal upper limb amyotrophy (HP:0007149)2.52524048
53Upper limb amyotrophy (HP:0009129)2.52524048
54Sparse eyelashes (HP:0000653)2.51550276
55Increased muscle lipid content (HP:0009058)2.50863943
56Cerebral edema (HP:0002181)2.49626551
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.44683856
58Neuroendocrine neoplasm (HP:0100634)2.41854621
59Death in infancy (HP:0001522)2.39526616
60Eczematoid dermatitis (HP:0000976)2.38322297
61Abnormality of renal resorption (HP:0011038)2.34951999
62Aplastic anemia (HP:0001915)2.34806464
63Hydroureter (HP:0000072)2.32857970
64Neurofibrillary tangles (HP:0002185)2.31874192
65Abnormal gallbladder physiology (HP:0012438)2.31765971
66Cholecystitis (HP:0001082)2.31765971
67Abnormality of the Achilles tendon (HP:0005109)2.30323062
68Thick nail (HP:0001805)2.29779963
69Growth hormone excess (HP:0000845)2.29576207
70Fragile skin (HP:0001030)2.28845167
71Abnormality of urine glucose concentration (HP:0011016)2.27142071
72Glycosuria (HP:0003076)2.27142071
73Reduced antithrombin III activity (HP:0001976)2.25951895
74Respiratory difficulties (HP:0002880)2.21390412
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20836483
76Abnormal protein N-linked glycosylation (HP:0012347)2.20836483
77Abnormal protein glycosylation (HP:0012346)2.20836483
78Abnormal glycosylation (HP:0012345)2.20836483
79Optic disc pallor (HP:0000543)2.19989925
80Abnormal hair laboratory examination (HP:0003328)2.19810700
81Dysostosis multiplex (HP:0000943)2.19301734
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.15774713
83Cervical subluxation (HP:0003308)2.13099047
84Short nail (HP:0001799)2.11667375
85Hypokinesia (HP:0002375)2.09872684
86CNS demyelination (HP:0007305)2.09801908
87Leukodystrophy (HP:0002415)2.09763952
88Neoplasm of head and neck (HP:0012288)2.09468452
89Esophageal neoplasm (HP:0100751)2.09468452
90Ridged nail (HP:0001807)2.08851082
91Microretrognathia (HP:0000308)2.07972523
92Limb dystonia (HP:0002451)2.07458797
93Macrocytic anemia (HP:0001972)2.06183164
94Cerebral palsy (HP:0100021)2.05769110
95Premature rupture of membranes (HP:0001788)2.03370521
96Spastic paraparesis (HP:0002313)2.03002137
97Supranuclear gaze palsy (HP:0000605)2.02826639
98Abnormality of the umbilical cord (HP:0010881)2.01660078
99Delusions (HP:0000746)2.01488084
100Cerebral inclusion bodies (HP:0100314)2.01213677
101Multiple enchondromatosis (HP:0005701)1.99196318
102Tongue fasciculations (HP:0001308)1.98463147
103Erythema (HP:0010783)1.97603320
104Abnormality of the distal phalanges of the toes (HP:0010182)1.96764378
105Systemic lupus erythematosus (HP:0002725)1.96446964
106Conjunctival hamartoma (HP:0100780)1.96172340
107Opisthotonus (HP:0002179)1.95902085
108Reduced subcutaneous adipose tissue (HP:0003758)1.95417353
109Flattened epiphyses (HP:0003071)1.94285554
110Rough bone trabeculation (HP:0100670)1.93940645
111Hypoplasia of dental enamel (HP:0006297)1.93688288
112Congenital ichthyosiform erythroderma (HP:0007431)1.92773727
113Abnormality of glycolipid metabolism (HP:0010969)1.92210742
114Abnormality of liposaccharide metabolism (HP:0010968)1.92210742
115Abnormality of glycosphingolipid metabolism (HP:0004343)1.92210742
116Abnormality of glycolysis (HP:0004366)1.91702217
117Increased serum pyruvate (HP:0003542)1.91702217
118Reticulocytopenia (HP:0001896)1.91508359
119Renal tubular dysfunction (HP:0000124)1.91057722
120Amyloidosis (HP:0011034)1.89970016
121Muscle fibrillation (HP:0010546)1.89606725
122Ragged-red muscle fibers (HP:0003200)1.88439390
123Beaking of vertebral bodies (HP:0004568)1.88205760
124Abnormal autonomic nervous system physiology (HP:0012332)1.87796547
125Neonatal onset (HP:0003623)1.87615622
126Acanthosis nigricans (HP:0000956)1.87370289
127Prolonged neonatal jaundice (HP:0006579)1.86147135
128Recurrent gram-negative bacterial infections (HP:0005420)1.85727585
129Epiphyseal stippling (HP:0010655)1.85445817
130Emotional lability (HP:0000712)1.84467382
131Pheochromocytoma (HP:0002666)1.84359522
132Hepatosplenomegaly (HP:0001433)1.83812652
133Increased IgM level (HP:0003496)1.82876571
134Selective tooth agenesis (HP:0001592)1.81772853
135Hyperphosphaturia (HP:0003109)1.81473164
136J-shaped sella turcica (HP:0002680)1.80180695
137Difficulty climbing stairs (HP:0003551)1.79943970
138Joint stiffness (HP:0001387)1.79608003
139Axonal loss (HP:0003447)1.79332438
140Hyperparathyroidism (HP:0000843)1.78915915
141Patent foramen ovale (HP:0001655)1.77625997
142Cerebral hypomyelination (HP:0006808)1.76300958
143Abnormality of the fetal cardiovascular system (HP:0010948)1.76170034
144Abnormal umbilical cord blood vessels (HP:0011403)1.76170034
145Single umbilical artery (HP:0001195)1.76170034
146Progressive neurologic deterioration (HP:0002344)1.75781205
147Polyphagia (HP:0002591)1.74865641
148Orchitis (HP:0100796)1.74420682
149Poor suck (HP:0002033)1.74319336
150Visual hallucinations (HP:0002367)1.73771928
151Methylmalonic aciduria (HP:0012120)1.73731948
152Biconcave vertebral bodies (HP:0004586)1.73314607
153Myositis (HP:0100614)1.72874801
154Pterygium (HP:0001059)1.71514691
155Generalized aminoaciduria (HP:0002909)1.70940928
156Abnormality of carpal bone ossification (HP:0006257)1.70618566
157Aplasia/Hypoplasia of the clavicles (HP:0006710)1.66678244
158Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65775348
159Fasciculations (HP:0002380)1.64559858
160Abnormality of polysaccharide metabolism (HP:0011012)1.64050343
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64050343
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64050343
163Back pain (HP:0003418)1.62732040
164Hyperthyroidism (HP:0000836)1.62356319
165Short femoral neck (HP:0100864)1.62200243
166Hypodontia (HP:0000668)1.61207774
167Hyperhidrosis (HP:0000975)1.60699626
168Abnormal trabecular bone morphology (HP:0100671)1.60614253
169Insomnia (HP:0100785)1.60455984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.80596853
2STK164.40710736
3VRK23.13596474
4BUB12.84083410
5TESK12.82163053
6LIMK12.67807537
7MAP3K122.59174462
8EPHA22.55033158
9* PIM22.47167792
10EPHB22.37134688
11MAP3K112.09414874
12MYLK2.04068509
13EIF2AK11.90161463
14TBK11.87269123
15LMTK21.86597791
16CAMKK21.79584659
17GRK51.78575942
18TESK21.76987013
19BLK1.68303435
20SIK11.67571466
21MST41.60633371
22STK241.59633073
23NME11.58906716
24TAOK11.53167974
25IRAK31.48520963
26TRIB31.45622502
27IRAK41.44839168
28EIF2AK31.44325963
29AKT31.42703423
30ABL21.41983416
31ILK1.40385831
32NTRK11.39747717
33BMPR1B1.37764001
34MST1R1.31934735
35SMG11.27772868
36MAP2K21.26938862
37CASK1.23724382
38MAP3K31.20454364
39VRK11.19827601
40WEE11.19291091
41PAK41.17884962
42TSSK61.16494661
43MAP3K141.14505816
44PAK61.13435114
45BRSK21.12919940
46TYK21.11269987
47PTK21.11120157
48ZAK1.09014509
49TLK11.07694713
50BMPR21.07649333
51PRKD21.05010318
52DYRK21.04524431
53ADRBK21.03811805
54PHKG11.03523556
55PHKG21.03523556
56SIK31.03428991
57NEK11.02492068
58CCNB11.00899424
59MAPKAPK31.00837755
60MINK10.99464579
61PRKD30.97764292
62AURKA0.96670319
63TEC0.96397399
64ERN10.95421489
65IKBKB0.93226364
66DAPK30.92837359
67CSNK1A1L0.92287021
68MATK0.91739899
69MAP2K30.91218567
70PLK40.90998871
71MAP4K20.90542038
72* PAK10.88017207
73CSNK1G20.87653686
74KDR0.87091651
75CDK80.85686345
76EPHA40.84236721
77KIT0.83297742
78TAOK20.83117544
79BCKDK0.83051271
80GRK70.82633046
81MUSK0.81726392
82DAPK10.79953064
83ERBB30.79531518
84LRRK20.78930442
85GRK60.78671304
86MET0.78443545
87SYK0.77635478
88BRSK10.76364005
89* PRKCI0.76229560
90* CAMK2G0.75887681
91CDK140.75182060
92MAPKAPK20.73392094
93* RPS6KA60.72959409
94ZAP700.72456418
95PLK30.72130281
96EIF2AK20.70787373
97BMX0.67915279
98DYRK30.67116705
99NEK90.67115789
100MAPKAPK50.66977655
101PINK10.66321306
102RIPK10.66318437
103BCR0.66255865
104MARK10.65498534
105* RPS6KL10.64841331
106* RPS6KC10.64841331
107BTK0.64732604
108MAP4K10.64725569
109IKBKE0.64583123
110CDK11A0.64193794
111SCYL20.63383919
112CDK150.62267211
113PLK20.62015639
114CDK180.60553096
115RPS6KA40.57834512
116CSNK1G30.56448948
117CAMK2B0.56178172
118CSNK1G10.56082214
119ROCK20.55121126
120TNK20.55058814
121ICK0.54284669
122MOS0.53611851
123DAPK20.51826826
124PRKCD0.51367108
125MAP2K10.50835553
126RIPK40.48329038
127CAMK2D0.48318784
128PRKG20.47362976
129MAPK40.46242083
130* CSNK2A10.45866294
131MAP2K70.45757911
132PDK20.44727727
133FER0.44709618
134PKN10.42949995
135CDK190.42909022
136AKT20.42882473
137LYN0.42812350
138ADRBK10.42741066
139ACVR1B0.41358728
140PTK2B0.41284115
141* BRAF0.40281489
142MARK20.40140827
143* PRKD10.39667523
144ROCK10.39107017
145PBK0.37500406
146STK380.34802540
147PLK10.34785717
148FLT30.33887660
149TGFBR10.33373829
150PKN20.32682783
151CDK50.31816854
152IRAK20.31311462
153PDPK10.30516826
154PIK3CG0.29695208
155CAMKK10.29163875
156DDR20.28346484

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.46524054
2Oxidative phosphorylation_Homo sapiens_hsa001904.15568394
3Ribosome_Homo sapiens_hsa030104.06443686
4Parkinsons disease_Homo sapiens_hsa050123.62662166
5RNA polymerase_Homo sapiens_hsa030203.25167335
6Protein export_Homo sapiens_hsa030602.92222528
7Huntingtons disease_Homo sapiens_hsa050162.68981395
8Alzheimers disease_Homo sapiens_hsa050102.33847750
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26217966
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25573781
11Pyrimidine metabolism_Homo sapiens_hsa002402.24369921
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09964383
13Regulation of autophagy_Homo sapiens_hsa041402.08175522
14Collecting duct acid secretion_Homo sapiens_hsa049661.99246224
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75492827
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.73630050
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67303009
18Folate biosynthesis_Homo sapiens_hsa007901.65880658
19Base excision repair_Homo sapiens_hsa034101.50904455
20DNA replication_Homo sapiens_hsa030301.49785555
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43473104
22Vibrio cholerae infection_Homo sapiens_hsa051101.41972124
23Biosynthesis of amino acids_Homo sapiens_hsa012301.41805064
24Rheumatoid arthritis_Homo sapiens_hsa053231.38968652
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.37522651
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37008955
27Phagosome_Homo sapiens_hsa041451.36297123
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32926173
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29517547
30Other glycan degradation_Homo sapiens_hsa005111.28843439
31Purine metabolism_Homo sapiens_hsa002301.28032066
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25976474
33Pentose phosphate pathway_Homo sapiens_hsa000301.25802399
34ECM-receptor interaction_Homo sapiens_hsa045121.24070141
35Glutathione metabolism_Homo sapiens_hsa004801.23101545
36Steroid biosynthesis_Homo sapiens_hsa001001.19900748
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18419095
38Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13739849
39Arachidonic acid metabolism_Homo sapiens_hsa005901.11899551
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11751823
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10240530
42Lysosome_Homo sapiens_hsa041421.05109183
43Nucleotide excision repair_Homo sapiens_hsa034201.03175043
44Sulfur metabolism_Homo sapiens_hsa009201.02312489
45Legionellosis_Homo sapiens_hsa051340.99517825
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95098509
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.91111910
48Cardiac muscle contraction_Homo sapiens_hsa042600.89433709
49Fructose and mannose metabolism_Homo sapiens_hsa000510.88820844
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86364579
51Homologous recombination_Homo sapiens_hsa034400.85760177
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.85260416
53Pertussis_Homo sapiens_hsa051330.84188908
54Endocytosis_Homo sapiens_hsa041440.82891605
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82879503
56Spliceosome_Homo sapiens_hsa030400.81002050
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80279000
58Allograft rejection_Homo sapiens_hsa053300.80155320
59Metabolic pathways_Homo sapiens_hsa011000.77836484
60Mismatch repair_Homo sapiens_hsa034300.77781198
61Asthma_Homo sapiens_hsa053100.76724143
62Shigellosis_Homo sapiens_hsa051310.76523555
63Fatty acid metabolism_Homo sapiens_hsa012120.74632691
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.74343151
65Phenylalanine metabolism_Homo sapiens_hsa003600.74009655
66Pyruvate metabolism_Homo sapiens_hsa006200.72887738
67Sulfur relay system_Homo sapiens_hsa041220.71788351
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70866304
69Epstein-Barr virus infection_Homo sapiens_hsa051690.70842464
70Graft-versus-host disease_Homo sapiens_hsa053320.70057917
71Galactose metabolism_Homo sapiens_hsa000520.69425441
72Dilated cardiomyopathy_Homo sapiens_hsa054140.67487131
73Basal transcription factors_Homo sapiens_hsa030220.67129062
74Leishmaniasis_Homo sapiens_hsa051400.65859303
75Salmonella infection_Homo sapiens_hsa051320.64350977
76Salivary secretion_Homo sapiens_hsa049700.61942517
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60419539
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58925140
79Sphingolipid metabolism_Homo sapiens_hsa006000.58871671
80N-Glycan biosynthesis_Homo sapiens_hsa005100.58470033
81Histidine metabolism_Homo sapiens_hsa003400.57986093
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57424360
83Synaptic vesicle cycle_Homo sapiens_hsa047210.56771484
84Vitamin B6 metabolism_Homo sapiens_hsa007500.54831749
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53574848
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51981198
87Peroxisome_Homo sapiens_hsa041460.49370724
88* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49072429
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49002495
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48588824
91Axon guidance_Homo sapiens_hsa043600.48122081
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47161763
93Notch signaling pathway_Homo sapiens_hsa043300.46735273
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46242325
95* Tuberculosis_Homo sapiens_hsa051520.45756109
96* Apoptosis_Homo sapiens_hsa042100.45308049
97Arginine and proline metabolism_Homo sapiens_hsa003300.43655284
98Malaria_Homo sapiens_hsa051440.43605424
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42520148
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.42353075
101Vitamin digestion and absorption_Homo sapiens_hsa049770.42082147
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41968927
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41642328
104Dopaminergic synapse_Homo sapiens_hsa047280.41445042
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40256736
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39303053
107Tyrosine metabolism_Homo sapiens_hsa003500.38020693
108Prion diseases_Homo sapiens_hsa050200.37948458
109Alcoholism_Homo sapiens_hsa050340.37429852
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36345499
111Fatty acid elongation_Homo sapiens_hsa000620.35803287
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35746156
113Carbon metabolism_Homo sapiens_hsa012000.33275980
114RNA transport_Homo sapiens_hsa030130.29794031
115Bladder cancer_Homo sapiens_hsa052190.29770431
116Type I diabetes mellitus_Homo sapiens_hsa049400.29205118
117p53 signaling pathway_Homo sapiens_hsa041150.29114141
118Chemical carcinogenesis_Homo sapiens_hsa052040.27647222
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27334618
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27311228
121beta-Alanine metabolism_Homo sapiens_hsa004100.27097439
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27012451
123Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.26811830
124Mineral absorption_Homo sapiens_hsa049780.26059823
125* Focal adhesion_Homo sapiens_hsa045100.24930739
126Antigen processing and presentation_Homo sapiens_hsa046120.24626138
127Autoimmune thyroid disease_Homo sapiens_hsa053200.24436398
128Ether lipid metabolism_Homo sapiens_hsa005650.24111733
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.23807648
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23310005
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22586929
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.22531364
133Gastric acid secretion_Homo sapiens_hsa049710.20271355
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18933034
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.18508623
136GABAergic synapse_Homo sapiens_hsa047270.18280427
137Amoebiasis_Homo sapiens_hsa051460.16197271
138Small cell lung cancer_Homo sapiens_hsa052220.15418730

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