BAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.65662062
2lysine catabolic process (GO:0006554)4.50369520
3lysine metabolic process (GO:0006553)4.50369520
4valine metabolic process (GO:0006573)4.38164614
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32575273
6tricarboxylic acid cycle (GO:0006099)4.26892170
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07116777
8negative regulation of cell killing (GO:0031342)4.07116777
9neutrophil activation involved in immune response (GO:0002283)4.06418879
10pentose-phosphate shunt (GO:0006098)3.96631763
11modulation by symbiont of host defense response (GO:0052031)3.94391071
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.94391071
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.94391071
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.94391071
15modulation by symbiont of host immune response (GO:0052553)3.94391071
16positive regulation by symbiont of host defense response (GO:0052509)3.94391071
17macrophage activation involved in immune response (GO:0002281)3.93157629
18tricarboxylic acid metabolic process (GO:0072350)3.87092887
19carnitine shuttle (GO:0006853)3.82846380
20viral transcription (GO:0019083)3.81587980
21response to peptidoglycan (GO:0032494)3.79614386
22fatty acid transmembrane transport (GO:1902001)3.77038155
23fatty acid beta-oxidation (GO:0006635)3.75437941
242-oxoglutarate metabolic process (GO:0006103)3.71608050
25translational termination (GO:0006415)3.68985450
26immunoglobulin mediated immune response (GO:0016064)3.68375522
27regulation of gamma-delta T cell activation (GO:0046643)3.68205847
28cysteine metabolic process (GO:0006534)3.65518460
29regulation of sequestering of triglyceride (GO:0010889)3.65197615
30antigen processing and presentation of endogenous antigen (GO:0019883)3.62315025
31low-density lipoprotein particle clearance (GO:0034383)3.58982698
32NADPH regeneration (GO:0006740)3.56139131
33maternal placenta development (GO:0001893)3.54314747
34carnitine transport (GO:0015879)3.53819186
35amino-acid betaine transport (GO:0015838)3.53819186
36response to type I interferon (GO:0034340)3.47747021
37regulation of fatty acid oxidation (GO:0046320)3.47626540
38translational elongation (GO:0006414)3.46765055
39sulfur amino acid catabolic process (GO:0000098)3.45482636
40oxidative phosphorylation (GO:0006119)3.44638301
41cellular response to type I interferon (GO:0071357)3.44468214
42type I interferon signaling pathway (GO:0060337)3.44468214
43regulation of gamma-delta T cell differentiation (GO:0045586)3.44025941
44carnitine transmembrane transport (GO:1902603)3.42755021
45macrophage activation (GO:0042116)3.42323034
46negative regulation of interleukin-12 production (GO:0032695)3.41799354
47NADH metabolic process (GO:0006734)3.39593769
48regulation of B cell receptor signaling pathway (GO:0050855)3.38762780
49negative regulation of cell size (GO:0045792)3.38615358
504-hydroxyproline metabolic process (GO:0019471)3.38412533
51regulation of fatty acid beta-oxidation (GO:0031998)3.37417685
52detection of other organism (GO:0098543)3.36106283
53fatty acid oxidation (GO:0019395)3.34938802
54negative regulation of lymphocyte mediated immunity (GO:0002707)3.30955176
55detection of bacterium (GO:0016045)3.30645084
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28575221
57microglial cell activation (GO:0001774)3.28169041
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.25762568
59lipid oxidation (GO:0034440)3.25001022
60regulation of interferon-beta biosynthetic process (GO:0045357)3.23595276
61negative regulation of erythrocyte differentiation (GO:0045647)3.22970143
62aspartate family amino acid catabolic process (GO:0009068)3.17684815
63fatty acid catabolic process (GO:0009062)3.17101037
64respiratory burst (GO:0045730)3.11905213
65oxaloacetate metabolic process (GO:0006107)3.09406451
66carnitine metabolic process (GO:0009437)3.08966000
67regulation of necroptotic process (GO:0060544)3.04972718
68interferon-gamma-mediated signaling pathway (GO:0060333)3.03636071
69branched-chain amino acid metabolic process (GO:0009081)3.03118724
70negative regulation of leukocyte mediated immunity (GO:0002704)3.00332249
71myeloid cell activation involved in immune response (GO:0002275)2.99619776
72regulation of interferon-alpha production (GO:0032647)2.98939176
73hepatocyte apoptotic process (GO:0097284)2.97112208
74quaternary ammonium group transport (GO:0015697)2.96177215
75negative regulation of T cell mediated immunity (GO:0002710)2.95528389
76fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.95361231
77short-chain fatty acid metabolic process (GO:0046459)2.95009754
78positive regulation of interferon-alpha production (GO:0032727)2.94361264
79oxygen transport (GO:0015671)2.93998282
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92120283
81alpha-linolenic acid metabolic process (GO:0036109)2.89106194
82succinate metabolic process (GO:0006105)2.89042474
83translational initiation (GO:0006413)2.88948927
84protein targeting to ER (GO:0045047)2.87475072
85germinal center formation (GO:0002467)2.86316970
86leukocyte aggregation (GO:0070486)2.86285696
87amino-acid betaine metabolic process (GO:0006577)2.85981728
88response to mercury ion (GO:0046689)2.85819669
89branched-chain amino acid catabolic process (GO:0009083)2.85333389
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85273890
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.85273890
92regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83997537
93defense response to protozoan (GO:0042832)2.83691131
94cellular protein complex disassembly (GO:0043624)2.83302165
95neutrophil activation (GO:0042119)2.83290860
96granulocyte activation (GO:0036230)2.82802994
97response to protozoan (GO:0001562)2.82262797
98detection of external biotic stimulus (GO:0098581)2.82077569
99viral life cycle (GO:0019058)2.81810148
100response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80959167
101response to host immune response (GO:0052572)2.80959167
102triglyceride catabolic process (GO:0019433)2.80798217
103lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80540132
104cellular response to virus (GO:0098586)2.80105823
105B cell mediated immunity (GO:0019724)2.79972023
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.79631409
107neutrophil mediated immunity (GO:0002446)2.79630099
108regulation of mast cell degranulation (GO:0043304)2.78627880
109ethanol oxidation (GO:0006069)2.78627343
110mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77165567
111positive regulation of fatty acid beta-oxidation (GO:0032000)2.76839089
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.76666995
113cotranslational protein targeting to membrane (GO:0006613)2.76084050
114epithelial cell-cell adhesion (GO:0090136)2.73572473
115ribosomal small subunit assembly (GO:0000028)2.72305274
116regulation of necrotic cell death (GO:0010939)2.71014916
117positive regulation of granulocyte differentiation (GO:0030854)2.70767216
118regulation of cholesterol storage (GO:0010885)2.70579499
119positive thymic T cell selection (GO:0045059)2.70140499
120protein localization to endoplasmic reticulum (GO:0070972)2.70054383
121positive regulation of fatty acid oxidation (GO:0046321)2.69834429
122hydrogen peroxide biosynthetic process (GO:0050665)2.69331428
123glucose catabolic process (GO:0006007)2.69187486
124sarcomere organization (GO:0045214)2.68518600
125positive regulation of lipid storage (GO:0010884)2.68082146
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67509906
127porphyrin-containing compound biosynthetic process (GO:0006779)2.66836607
128heme biosynthetic process (GO:0006783)2.65234731
129plasma membrane repair (GO:0001778)2.65013202
130positive regulation of B cell differentiation (GO:0045579)2.64854519
131peptidyl-proline hydroxylation (GO:0019511)2.64572714
132positive regulation of triglyceride metabolic process (GO:0090208)2.63953275
133monocarboxylic acid catabolic process (GO:0072329)2.63739342
134DNA deamination (GO:0045006)2.62985891
135regulation of alpha-beta T cell proliferation (GO:0046640)2.62871562
136reactive oxygen species biosynthetic process (GO:1903409)2.62682089
137glyoxylate metabolic process (GO:0046487)2.62051559
138NADP metabolic process (GO:0006739)2.61600326
139regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.61013496
140positive regulation of histone deacetylation (GO:0031065)2.60156667
141galactose catabolic process (GO:0019388)2.60130239
142protein hydroxylation (GO:0018126)2.59649924
143acetyl-CoA metabolic process (GO:0006084)2.59295038
144protoporphyrinogen IX metabolic process (GO:0046501)2.58664889
145biotin metabolic process (GO:0006768)2.58593619
146cellular response to interferon-beta (GO:0035458)2.58350099
147neutral lipid catabolic process (GO:0046461)2.57633574
148acylglycerol catabolic process (GO:0046464)2.57633574
149skeletal muscle adaptation (GO:0043501)2.57619776
150response to interferon-beta (GO:0035456)2.56257032
151cellular extravasation (GO:0045123)2.56130188
152maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.56098918
153protein retention in ER lumen (GO:0006621)2.55918103
154B cell receptor signaling pathway (GO:0050853)2.55709652
155detection of molecule of bacterial origin (GO:0032490)2.54702071
156response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54701641
157response to host (GO:0075136)2.54701641
158response to host defenses (GO:0052200)2.54701641
159regulation of granulocyte differentiation (GO:0030852)2.54588679
160bundle of His cell to Purkinje myocyte communication (GO:0086069)2.52978473
161negative regulation of interleukin-6 production (GO:0032715)2.52559707
162positive regulation of lamellipodium assembly (GO:0010592)2.52479169
163regulation of mast cell activation involved in immune response (GO:0033006)2.52421880
164regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51798139
165ethanol metabolic process (GO:0006067)2.51395894
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50889693
167protein complex disassembly (GO:0043241)2.49766580
168gas transport (GO:0015669)2.48569875
169negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.48151499
170NIK/NF-kappaB signaling (GO:0038061)2.48078050
171homocysteine metabolic process (GO:0050667)2.46490086
172negative regulation of heart growth (GO:0061117)2.46145583
173negative regulation of cardiac muscle tissue growth (GO:0055022)2.46145583
174regulation of triglyceride catabolic process (GO:0010896)2.45272472
175positive regulation of triglyceride biosynthetic process (GO:0010867)2.45268846
176modulation by virus of host process (GO:0019054)2.44656056
177production of molecular mediator involved in inflammatory response (GO:0002532)2.43978138
178cellular response to exogenous dsRNA (GO:0071360)2.43537501
179leukocyte degranulation (GO:0043299)2.42673340
180cellular ketone body metabolic process (GO:0046950)2.42531915
181positive regulation of interferon-beta production (GO:0032728)2.42252686
182desmosome organization (GO:0002934)2.41944608
183modulation by symbiont of host cellular process (GO:0044068)2.41907548
184regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41048241
185response to muramyl dipeptide (GO:0032495)2.40285149
1863-UTR-mediated mRNA stabilization (GO:0070935)2.40091779
187detection of biotic stimulus (GO:0009595)2.39703296
188lipid particle organization (GO:0034389)2.39635028
189regulation of translational termination (GO:0006449)2.39530541
190regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.39488960
191positive regulation of type 2 immune response (GO:0002830)2.38298617
192T-helper 1 type immune response (GO:0042088)2.37702781
193negative regulation of necroptotic process (GO:0060546)2.37162145
194positive regulation of interleukin-10 production (GO:0032733)2.36897727
195striated muscle atrophy (GO:0014891)2.36872766
196negative regulation of type I interferon production (GO:0032480)2.35589906
197mature B cell differentiation involved in immune response (GO:0002313)2.35315496
198cellular response to interferon-gamma (GO:0071346)2.35261519

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.60399378
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.47985969
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.85845849
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.61354245
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.90869348
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.86845857
7ZNF263_19887448_ChIP-Seq_K562_Human2.85338826
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.72641447
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.64749279
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.59987222
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.57686383
12SCL_19346495_ChIP-Seq_HPC-7_Human2.48447340
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.47958058
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39573054
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.28483329
16GATA1_22025678_ChIP-Seq_K562_Human2.23558348
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17220581
18CLOCK_20551151_ChIP-Seq_293T_Human2.10767104
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06480077
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06011185
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05761015
22* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04487715
23E2F7_22180533_ChIP-Seq_HELA_Human1.99533498
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95636495
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93327691
26* SPI1_23547873_ChIP-Seq_NB4_Human1.92920028
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.90271471
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.87345872
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87051529
30* MYC_18555785_ChIP-Seq_MESCs_Mouse1.85248254
31MYC_22102868_ChIP-Seq_BL_Human1.81385859
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.79433135
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79238784
34ATF3_27146783_Chip-Seq_COLON_Human1.77492086
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77327856
36MYB_26560356_Chip-Seq_TH2_Human1.76600169
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74908306
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.74234618
39GATA1_19941826_ChIP-Seq_K562_Human1.71781103
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.71735987
41VDR_21846776_ChIP-Seq_THP-1_Human1.68959448
42LXR_22292898_ChIP-Seq_THP-1_Human1.66756989
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.65212248
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.63452143
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60179097
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.59064140
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57655298
48SPI1_23127762_ChIP-Seq_K562_Human1.57025365
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55966322
50MYB_26560356_Chip-Seq_TH1_Human1.55927727
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.54189651
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52658476
53SMC4_20622854_ChIP-Seq_HELA_Human1.49621357
54* RACK7_27058665_Chip-Seq_MCF-7_Human1.49166894
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47804038
56AR_21909140_ChIP-Seq_LNCAP_Human1.46548955
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44711354
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43166408
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42218729
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41735247
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36965781
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34184361
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33193534
64* ESR2_21235772_ChIP-Seq_MCF-7_Human1.31596837
65TCF7_22412390_ChIP-Seq_EML_Mouse1.31391844
66RUNX_20019798_ChIP-Seq_JUKART_Human1.30641963
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29296751
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28873736
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28825825
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28240547
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27705398
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27122823
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26367296
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26105168
75* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24269784
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23528717
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23348786
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23303811
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22429285
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22265312
81GATA6_25053715_ChIP-Seq_YYC3_Human1.21581410
82STAT1_20625510_ChIP-Seq_HELA_Human1.21409190
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20456481
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20228310
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19928595
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19353280
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19219928
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19048685
89* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18836134
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18585134
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18338735
92E2F1_20622854_ChIP-Seq_HELA_Human1.18207528
93P300_27268052_Chip-Seq_Bcells_Human1.18007157
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17564569
95KDM2B_26808549_Chip-Seq_DND41_Human1.17264488
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17113179
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16678469
98GATA3_27048872_Chip-Seq_THYMUS_Human1.16401709
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16064803
100* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16033827
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15040983
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14909516
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14543265
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14177123
105* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13398935
106GATA2_19941826_ChIP-Seq_K562_Human1.13096702
107P68_20966046_ChIP-Seq_HELA_Human1.12875779
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12660772
109MAF_26560356_Chip-Seq_TH1_Human1.12343109
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11988967
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11298595
112FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11110242
113CTCF_21964334_Chip-Seq_Bcells_Human1.09718354
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09713967
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09595371
116SA1_27219007_Chip-Seq_Bcells_Human1.09252243
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08539266
118BCOR_27268052_Chip-Seq_Bcells_Human1.06483891
119XRN2_22483619_ChIP-Seq_HELA_Human1.05453255
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.04377635
121UTX_26944678_Chip-Seq_JUKART_Human1.04252800
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.04142611
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03975479
124CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03411120
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.02663155
126* ELF1_20517297_ChIP-Seq_JURKAT_Human1.02637328
127GATA4_25053715_ChIP-Seq_YYC3_Human1.02624612
128TRIM28_21343339_ChIP-Seq_HEK293_Human1.02608178
129P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01492077
130VDR_24763502_ChIP-Seq_THP-1_Human1.01152689
131TFEB_21752829_ChIP-Seq_HELA_Human1.00838212
132NCOR1_26117541_ChIP-Seq_K562_Human1.00589064
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00204789
134BCL6_27268052_Chip-Seq_Bcells_Human0.99086491
135CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99010637
136CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98879102
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98171083
138CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98006940
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95939186
140TBX20_22080862_ChIP-Seq_HEART_Mouse0.95674462
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.95674462
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.95284611
143GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94248167
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92614849
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91388920
146FOXP1_21924763_ChIP-Seq_HESCs_Human0.91153068
147FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91150935
148CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90549278
149MAF_26560356_Chip-Seq_TH2_Human0.90317713
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.90284373
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89760985
152CHD1_26751641_Chip-Seq_LNCaP_Human0.89757593
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89245675
154E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88630301
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.87402259
156CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87342878
157* PHF8_20622854_ChIP-Seq_HELA_Human0.87237656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.53967459
2MP0001835_abnormal_antigen_presentation3.22292181
3MP0003724_increased_susceptibility_to3.11669542
4MP0005451_abnormal_body_composition3.04792661
5MP0010234_abnormal_vibrissa_follicle2.92490769
6MP0005360_urolithiasis2.92195903
7MP0009785_altered_susceptibility_to2.52510521
8MP0002139_abnormal_hepatobiliary_system2.48661755
9MP0005025_abnormal_response_to2.43172701
10MP0000685_abnormal_immune_system2.42960616
11MP0004185_abnormal_adipocyte_glucose2.39754186
12MP0004130_abnormal_muscle_cell2.38583595
13MP0002148_abnormal_hypersensitivity_rea2.36775114
14MP0001800_abnormal_humoral_immune2.33117984
15MP0002419_abnormal_innate_immunity2.33021551
16MP0005000_abnormal_immune_tolerance2.30993815
17MP0005666_abnormal_adipose_tissue2.28977036
18MP0005083_abnormal_biliary_tract2.26587691
19MP0005387_immune_system_phenotype2.25757297
20MP0001790_abnormal_immune_system2.25757297
21MP0010352_gastrointestinal_tract_polyps2.21643935
22MP0005671_abnormal_response_to2.21361300
23MP0003763_abnormal_thymus_physiology2.19564657
24MP0003646_muscle_fatigue2.16337492
25MP0005365_abnormal_bile_salt2.10794016
26MP0002723_abnormal_immune_serum2.09710211
27MP0009278_abnormal_bone_marrow2.08316884
28MP0003806_abnormal_nucleotide_metabolis2.03502659
29MP0002452_abnormal_antigen_presenting1.99115037
30MP0006082_CNS_inflammation1.98509909
31MP0002420_abnormal_adaptive_immunity1.96603644
32MP0002837_dystrophic_cardiac_calcinosis1.95334049
33MP0003300_gastrointestinal_ulcer1.94939933
34MP0005085_abnormal_gallbladder_physiolo1.94775408
35MP0001819_abnormal_immune_cell1.94324420
36MP0008260_abnormal_autophagy1.86786682
37MP0009333_abnormal_splenocyte_physiolog1.86062971
38MP0001666_abnormal_nutrient_absorption1.77960080
39MP0000751_myopathy1.73046102
40MP0003191_abnormal_cellular_cholesterol1.72486605
41MP0005670_abnormal_white_adipose1.69566674
42MP0003566_abnormal_cell_adhesion1.68455755
43MP0000750_abnormal_muscle_regeneration1.64220718
44MP0009643_abnormal_urine_homeostasis1.61333678
45MP0006036_abnormal_mitochondrial_physio1.61202777
46MP0002398_abnormal_bone_marrow1.61072815
47MP0004084_abnormal_cardiac_muscle1.60862512
48MP0003656_abnormal_erythrocyte_physiolo1.60465146
49MP0004381_abnormal_hair_follicle1.60448817
50MP0005275_abnormal_skin_tensile1.58952057
51MP0002132_abnormal_respiratory_system1.58448533
52MP0003866_abnormal_defecation1.57147375
53MP0002332_abnormal_exercise_endurance1.55989488
54MP0005330_cardiomyopathy1.55906567
55MP0001845_abnormal_inflammatory_respons1.54956911
56MP0002405_respiratory_system_inflammati1.54540336
57MP0009764_decreased_sensitivity_to1.53224647
58MP0003172_abnormal_lysosome_physiology1.52759597
59MP0000716_abnormal_immune_system1.51438677
60MP0003252_abnormal_bile_duct1.50927256
61MP0004087_abnormal_muscle_fiber1.50156386
62MP0005332_abnormal_amino_acid1.50117969
63MP0008438_abnormal_cutaneous_collagen1.48224005
64MP0005310_abnormal_salivary_gland1.46102938
65MP0002796_impaired_skin_barrier1.45951098
66MP0005375_adipose_tissue_phenotype1.44675587
67MP0010329_abnormal_lipoprotein_level1.42195016
68MP0005464_abnormal_platelet_physiology1.41094210
69MP0005319_abnormal_enzyme/_coenzyme1.40446597
70MP0008469_abnormal_protein_level1.40282421
71MP0002138_abnormal_hepatobiliary_system1.40098742
72MP0009840_abnormal_foam_cell1.39371493
73MP0006054_spinal_hemorrhage1.37925861
74MP0003221_abnormal_cardiomyocyte_apopto1.35845901
75MP0001533_abnormal_skeleton_physiology1.33986990
76MP0000689_abnormal_spleen_morphology1.33249849
77MP0003283_abnormal_digestive_organ1.32909520
78MP0003183_abnormal_peptide_metabolism1.31720639
79MP0002429_abnormal_blood_cell1.31291510
80MP0000747_muscle_weakness1.30627764
81MP0002722_abnormal_immune_system1.29933715
82MP0002971_abnormal_brown_adipose1.29497686
83MP0000609_abnormal_liver_physiology1.25802235
84MP0002269_muscular_atrophy1.23294300
85MP0005058_abnormal_lysosome_morphology1.21552055
86MP0003186_abnormal_redox_activity1.19925042
87MP0008875_abnormal_xenobiotic_pharmacok1.19725924
88MP0000537_abnormal_urethra_morphology1.19298301
89MP0005075_abnormal_melanosome_morpholog1.17805695
90MP0000749_muscle_degeneration1.16861311
91MP0004147_increased_porphyrin_level1.15956342
92MP0001756_abnormal_urination1.15904968
93MP0005636_abnormal_mineral_homeostasis1.15799237
94MP0000465_gastrointestinal_hemorrhage1.14776440
95MP0002877_abnormal_melanocyte_morpholog1.12555006
96MP0004957_abnormal_blastocyst_morpholog1.11209747
97MP0003075_altered_response_to1.10864512
98MP0004215_abnormal_myocardial_fiber1.10410508
99MP0002118_abnormal_lipid_homeostasis1.10156040
100MP0010630_abnormal_cardiac_muscle1.09700896
101MP0005076_abnormal_cell_differentiation1.09377950
102MP0005501_abnormal_skin_physiology1.09105741
103MP0008775_abnormal_heart_ventricle1.07606779
104MP0004036_abnormal_muscle_relaxation1.05076829
105MP0004808_abnormal_hematopoietic_stem1.04690754
106MP0003303_peritoneal_inflammation1.04384546
107MP0005410_abnormal_fertilization1.02961948
108MP0001765_abnormal_ion_homeostasis1.02622518
109MP0004264_abnormal_extraembryonic_tissu1.02166381
110MP0000490_abnormal_crypts_of1.01620019
111MP0003693_abnormal_embryo_hatching1.01093219
112MP0002396_abnormal_hematopoietic_system1.00710525
113MP0008961_abnormal_basal_metabolism1.00604765
114MP0004043_abnormal_pH_regulation1.00527513
115MP0000703_abnormal_thymus_morphology0.99210277
116MP0000759_abnormal_skeletal_muscle0.97618359
117MP0010307_abnormal_tumor_latency0.97281856
118MP0001853_heart_inflammation0.97121234
119MP0005166_decreased_susceptibility_to0.97070553
120MP0005385_cardiovascular_system_phenoty0.96491977
121MP0001544_abnormal_cardiovascular_syste0.96491977
122MP0002166_altered_tumor_susceptibility0.96273284
123MP0005584_abnormal_enzyme/coenzyme_acti0.94888674
124MP0003195_calcinosis0.93931213
125MP0002106_abnormal_muscle_physiology0.93186836
126MP0001958_emphysema0.92483020
127MP0001545_abnormal_hematopoietic_system0.92481071
128MP0005397_hematopoietic_system_phenotyp0.92481071
129MP0001663_abnormal_digestive_system0.90545207
130MP0002136_abnormal_kidney_physiology0.89225788
131MP0005023_abnormal_wound_healing0.89170994
132MP0005266_abnormal_metabolism0.88588527
133MP0000343_altered_response_to0.88120595
134MP0000015_abnormal_ear_pigmentation0.87232867
135MP0002060_abnormal_skin_morphology0.86684868
136MP0004510_myositis0.86653814
137MP0000733_abnormal_muscle_development0.86179937
138MP0003453_abnormal_keratinocyte_physiol0.86062997
139MP0001873_stomach_inflammation0.85808976
140MP0000858_altered_metastatic_potential0.85152661
141MP0002970_abnormal_white_adipose0.84383643
142MP0001849_ear_inflammation0.84306396
143MP0002234_abnormal_pharynx_morphology0.83052157
144MP0003828_pulmonary_edema0.82727127
145MP0002009_preneoplasia0.82499649
146MP0004947_skin_inflammation0.81917911
147MP0003436_decreased_susceptibility_to0.81673804
148MP0000477_abnormal_intestine_morphology0.80882226
149MP0008874_decreased_physiological_sensi0.80837919
150MP0010155_abnormal_intestine_physiology0.79896100
151MP0004019_abnormal_vitamin_homeostasis0.79774661
152MP0003567_abnormal_fetal_cardiomyocyte0.79633451
153* MP0000598_abnormal_liver_morphology0.79015828
154MP0002972_abnormal_cardiac_muscle0.78707613
155MP0004233_abnormal_muscle_weight0.76801453
156MP0005167_abnormal_blood-brain_barrier0.76499176
157MP0001730_embryonic_growth_arrest0.76132160
158MP0009763_increased_sensitivity_to0.74898460
159MP0005165_increased_susceptibility_to0.72395462
160MP0004484_altered_response_of0.69878677
161MP0006035_abnormal_mitochondrial_morpho0.68231913

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.44251242
2Recurrent abscess formation (HP:0002722)4.39547146
3Eczematoid dermatitis (HP:0000976)4.37102559
4Myositis (HP:0100614)4.10206809
5Hypochromic microcytic anemia (HP:0004840)4.08747940
6Myoglobinuria (HP:0002913)3.92128762
7Elevated erythrocyte sedimentation rate (HP:0003565)3.85290098
8Orchitis (HP:0100796)3.80363223
9Stomatitis (HP:0010280)3.73223729
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.72176652
11Rhabdomyolysis (HP:0003201)3.57551916
12Hypochromic anemia (HP:0001931)3.53087539
13Retrobulbar optic neuritis (HP:0100654)3.50201819
14Optic neuritis (HP:0100653)3.50201819
15Multiple enchondromatosis (HP:0005701)3.40974178
16Abnormality of the heme biosynthetic pathway (HP:0010472)3.26895665
17Abnormality of macrophages (HP:0004311)3.23465765
18Right ventricular cardiomyopathy (HP:0011663)3.23082362
19Increased IgE level (HP:0003212)3.21052353
20Abnormality of fatty-acid metabolism (HP:0004359)3.18584192
21Gout (HP:0001997)3.12647828
22Obstructive lung disease (HP:0006536)3.10539738
23Chronic obstructive pulmonary disease (HP:0006510)3.10539738
24Recurrent fungal infections (HP:0002841)3.08695758
25Exercise-induced muscle cramps (HP:0003710)3.07035702
26Hyperglycinuria (HP:0003108)3.05041824
27Urticaria (HP:0001025)2.99134423
28Mediastinal lymphadenopathy (HP:0100721)2.97848380
29Increased connective tissue (HP:0009025)2.92915520
30Abnormal cartilage morphology (HP:0002763)2.89320677
31Conjunctival hamartoma (HP:0100780)2.89191971
32Abnormality of glycolipid metabolism (HP:0010969)2.88386874
33Abnormality of liposaccharide metabolism (HP:0010968)2.88386874
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.88386874
35Increased cerebral lipofuscin (HP:0011813)2.88311105
36Increased neuronal autofluorescent lipopigment (HP:0002074)2.86289046
37Gastrointestinal infarctions (HP:0005244)2.85346339
38Hypoglycemic coma (HP:0001325)2.85172761
39Microcytic anemia (HP:0001935)2.80098618
40Recurrent skin infections (HP:0001581)2.77355120
41Difficulty climbing stairs (HP:0003551)2.75451616
42Exercise-induced myalgia (HP:0003738)2.73137469
43Meningitis (HP:0001287)2.72934145
44Recurrent gram-negative bacterial infections (HP:0005420)2.72911802
45Hyperammonemia (HP:0001987)2.70878639
46Abnormality of cells of the erythroid lineage (HP:0012130)2.68981145
47Abnormality of iron homeostasis (HP:0011031)2.68079608
48Encephalitis (HP:0002383)2.67917080
49Type 1 muscle fiber predominance (HP:0003803)2.64959531
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63928361
51Dicarboxylic aciduria (HP:0003215)2.63928361
52Ketosis (HP:0001946)2.63385198
53Ketoacidosis (HP:0001993)2.60606035
54Sudden death (HP:0001699)2.59423173
55Hyporeflexia of lower limbs (HP:0002600)2.58548285
56Ventricular tachycardia (HP:0004756)2.50810251
57Recurrent viral infections (HP:0004429)2.50665944
58Abnormality of the Achilles tendon (HP:0005109)2.50461831
59Paralysis (HP:0003470)2.47855663
60Achilles tendon contracture (HP:0001771)2.46943832
61Difficulty running (HP:0009046)2.46851134
62Abnormality of glycine metabolism (HP:0010895)2.45432514
63Abnormality of serine family amino acid metabolism (HP:0010894)2.45432514
64Gingivitis (HP:0000230)2.44553159
65Keratoconjunctivitis sicca (HP:0001097)2.44139938
66Muscle fiber splitting (HP:0003555)2.41579063
67Increased muscle lipid content (HP:0009058)2.41311301
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.39236233
69Asymmetric septal hypertrophy (HP:0001670)2.39198413
70Inflammation of the large intestine (HP:0002037)2.36222557
71Abnormal number of erythroid precursors (HP:0012131)2.35532638
72Ulnar deviation of the wrist (HP:0003049)2.35202020
73Vasculitis (HP:0002633)2.33243717
74Visual hallucinations (HP:0002367)2.32330649
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31700446
76Chronic mucocutaneous candidiasis (HP:0002728)2.31234956
77Recurrent cutaneous fungal infections (HP:0011370)2.31234956
78Abnormality of purine metabolism (HP:0004352)2.31188255
79Abnormality of transition element cation homeostasis (HP:0011030)2.29502206
80Chronic otitis media (HP:0000389)2.29067652
81Colitis (HP:0002583)2.27533941
82Keratoconjunctivitis (HP:0001096)2.27204129
83Chest pain (HP:0100749)2.27000434
84Increased purine levels (HP:0004368)2.26301609
85Hyperuricemia (HP:0002149)2.26301609
86Absent/shortened dynein arms (HP:0200106)2.25476635
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.25476635
88Fatigue (HP:0012378)2.23915597
89Gastrointestinal inflammation (HP:0004386)2.23831533
90Nausea (HP:0002018)2.22280656
91Bundle branch block (HP:0011710)2.20167476
92Muscle stiffness (HP:0003552)2.19946531
93Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.19943209
94Slow saccadic eye movements (HP:0000514)2.19412642
95Polycythemia (HP:0001901)2.18935340
96Petechiae (HP:0000967)2.18695683
97Abnormality of the nasal mucosa (HP:0000433)2.17055874
98Distal arthrogryposis (HP:0005684)2.16558695
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15855956
100Muscle fiber inclusion bodies (HP:0100299)2.15471350
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13363670
102Hyperglycinemia (HP:0002154)2.13205657
103Progressive muscle weakness (HP:0003323)2.13176795
104Autoimmune thrombocytopenia (HP:0001973)2.12379321
105Prolonged bleeding time (HP:0003010)2.10617872
106Cellulitis (HP:0100658)2.10338555
107Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.09843323
108Rectal prolapse (HP:0002035)2.09711321
109Xanthomatosis (HP:0000991)2.08797783
110Ileus (HP:0002595)2.08795383
111Palpitations (HP:0001962)2.08727960
112Angiofibromas (HP:0010615)2.06945390
113Adenoma sebaceum (HP:0009720)2.06945390
114Arterial thrombosis (HP:0004420)2.05120775
115Protrusio acetabuli (HP:0003179)2.04712210
116Hemoptysis (HP:0002105)2.04016996
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03642888
118Malnutrition (HP:0004395)2.03474504
119Granulocytopenia (HP:0001913)2.03035808
120Distal lower limb muscle weakness (HP:0009053)2.02940899
121Anorexia (HP:0002039)2.01496646
122Lymphangioma (HP:0100764)2.00924458
123Trismus (HP:0000211)1.99695143
124Nasal polyposis (HP:0100582)1.98937514
125Alkalosis (HP:0001948)1.97918010
126Hyperactive renin-angiotensin system (HP:0000841)1.97594649
127Spastic diplegia (HP:0001264)1.96851763
128Acute hepatic failure (HP:0006554)1.93366051
129Ankle contracture (HP:0006466)1.93121195
130Abnormality of T cells (HP:0002843)1.92324675
131Hepatic necrosis (HP:0002605)1.91929535
132Amyloidosis (HP:0011034)1.91648898
133Deep venous thrombosis (HP:0002625)1.91353817
134Abnormal respiratory motile cilium morphology (HP:0005938)1.89764136
135Abnormal respiratory epithelium morphology (HP:0012253)1.89764136
136Reticulocytosis (HP:0001923)1.89619432
137Myopathic facies (HP:0002058)1.89591275
138Recurrent bronchitis (HP:0002837)1.88884040
139Hypergammaglobulinemia (HP:0010702)1.87335060
140Lipoatrophy (HP:0100578)1.86975095
141Flat acetabular roof (HP:0003180)1.86499197
142Abnormality of chloride homeostasis (HP:0011422)1.85886843
143Mildly elevated creatine phosphokinase (HP:0008180)1.83963746
144Episodic fever (HP:0001954)1.83563940
145Hamartoma of the eye (HP:0010568)1.83503012
146Increased variability in muscle fiber diameter (HP:0003557)1.83477699
147Global brain atrophy (HP:0002283)1.83400595
148Abnormality of T cell physiology (HP:0011840)1.81831431
149Increased serum ferritin (HP:0003281)1.81583159
150Frequent falls (HP:0002359)1.81403609
151Abnormality of skeletal muscle fiber size (HP:0012084)1.81239613
152Autoimmune hemolytic anemia (HP:0001890)1.81086722
153Fragile skin (HP:0001030)1.80676426
154Limb-girdle muscle atrophy (HP:0003797)1.80309996
155Hyperkalemia (HP:0002153)1.80305302
156Abnormality of the endocardium (HP:0004306)1.80193154
157Generalized aminoaciduria (HP:0002909)1.80159970
158Pulmonary infiltrates (HP:0002113)1.79982959
159Spontaneous hematomas (HP:0007420)1.79211115
160Absent phalangeal crease (HP:0006109)1.79041081
161Cerebral aneurysm (HP:0004944)1.78952483
162Alveolar cell carcinoma (HP:0006519)1.78797042
163Leukocytosis (HP:0001974)1.78759185
164Metabolic acidosis (HP:0001942)1.78727059
165Aplasia/Hypoplasia of the thymus (HP:0010515)1.78589273
166Chronic sinusitis (HP:0011109)1.78518501
167Loss of speech (HP:0002371)1.77062673
168Pustule (HP:0200039)1.75527024
169Hydroxyprolinuria (HP:0003080)1.74984837
170Abnormality of proline metabolism (HP:0010907)1.74984837
171Hypoalphalipoproteinemia (HP:0003233)1.72960943
172Nemaline bodies (HP:0003798)1.72258301
173Late onset (HP:0003584)1.71613322
174Abnormality of the 1st metacarpal (HP:0010009)1.70816823
175Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70512582
176Ventricular fibrillation (HP:0001663)1.69920876
177Abnormal hemoglobin (HP:0011902)1.69895940
178Acanthosis nigricans (HP:0000956)1.69609600
179Abnormality of reticulocytes (HP:0004312)1.69496583
180Cupped ribs (HP:0000887)1.69429540
181Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69152528
182Cerebral edema (HP:0002181)1.69014898
183Poikilocytosis (HP:0004447)1.67623100
184Increased intramyocellular lipid droplets (HP:0012240)1.67177932
185Ragged-red muscle fibers (HP:0003200)1.66900718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.46633760
2PKN24.12759967
3PDK32.95716577
4PDK42.95716577
5RIPK42.94915373
6BCKDK2.90205108
7TTN2.78446290
8ERN12.58642579
9TAOK22.52537494
10NME22.41085942
11EEF2K2.32745627
12IRAK42.30234566
13NEK12.26923962
14RIPK12.18847085
15LRRK22.11539155
16TESK12.10653246
17SCYL21.97363863
18PRPF4B1.92281499
19BLK1.83464705
20MAP3K141.79630356
21TNK21.77968757
22MAP3K101.77939318
23IKBKB1.73792252
24LMTK21.67510014
25PDK21.64799065
26IKBKE1.62700509
27MAPKAPK31.54174548
28MST1R1.51597872
29CSK1.50769610
30IRAK31.48170578
31ILK1.43415489
32PTK61.42685921
33MAP2K31.38903358
34MAP3K111.38383389
35FES1.37240952
36TLK11.35771175
37JAK31.30930128
38SIK11.28999248
39BTK1.28546292
40BMPR21.27999399
41NEK21.27410844
42SYK1.26303910
43PAK41.24777742
44MAPK121.23559221
45DMPK1.22418559
46SMG11.19596213
47TXK1.13972124
48FLT31.05768461
49EIF2AK11.01922815
50TAOK10.98131110
51RPS6KA40.96823632
52MAP3K130.96252249
53MAP3K30.95228532
54KSR20.94543159
55HCK0.94329422
56TBK10.92762402
57PIM10.92712124
58PIM20.92658011
59IRAK20.92631555
60WNK40.91510821
61PDGFRA0.91385609
62TESK20.91050628
63ZAP700.89766007
64KDR0.88596591
65BMX0.88503376
66MAP3K80.88438728
67CDK60.88164879
68LYN0.87834031
69CAMK1D0.86044711
70RPS6KB20.84654615
71TRPM70.83648261
72MAP2K20.83523640
73TGFBR20.82338087
74KIT0.80177045
75DAPK30.78978741
76FGFR40.78707024
77IRAK10.77262442
78NEK90.76589398
79STK100.76567477
80MATK0.73338597
81CDK40.72609043
82CSF1R0.71604122
83NME10.71387917
84MARK30.70071869
85MYLK0.70069348
86OBSCN0.69545943
87TAOK30.68919186
88PDPK10.68812892
89CAMKK10.68718240
90LCK0.66656200
91DYRK1B0.66434056
92MAPK110.66199315
93NEK60.65191663
94PAK20.63663877
95MAP2K10.63596137
96STK110.63310193
97MUSK0.63158710
98ABL20.63105068
99MAP4K10.62694523
100PHKG10.62658680
101PHKG20.62658680
102MAP3K50.62401939
103PIK3CG0.62317422
104PRKD30.62185976
105MAP3K70.61382961
106PDK10.61355536
107FGR0.60890341
108CHUK0.60814268
109OXSR10.60537462
110EPHB20.60313932
111TYK20.58641257
112EPHB10.58591396
113RET0.58340619
114SIK20.57454916
115MAPK150.54867536
116MAP3K10.54777660
117PIK3CA0.53500625
118ICK0.53490536
119HIPK20.53301914
120RPS6KC10.53172975
121RPS6KL10.53172975
122JAK20.53151215
123GRK50.52785876
124RPS6KA60.52654533
125MAP3K20.52529449
126MAP2K60.51161443
127MAP2K40.50551867
128LATS20.50403300
129GRK60.49981964
130GRK70.49328261
131CAMKK20.48871489
132LATS10.48123968
133PRKG20.47924243
134RPS6KA50.47916942
135WEE10.46966640
136ITK0.46935876
137MTOR0.46787632
138PRKAA20.45605244
139MARK20.45378989
140AURKB0.43043374
141MAPK40.42712667
142JAK10.42419390
143PTK20.42343222
144TEC0.41613510
145TTK0.41581551
146ACVR1B0.41502048
147STK30.41410462
148FER0.40602789
149PRKD20.40277046
150WNK30.39112600
151LIMK10.39066335
152AKT20.38989083
153TGFBR10.38412504
154DDR20.37486907
155DYRK30.36478882
156ALK0.34735423
157STK240.34424221

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.09171717
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.34560617
3Propanoate metabolism_Homo sapiens_hsa006403.01978635
4Fatty acid degradation_Homo sapiens_hsa000712.97435911
5Allograft rejection_Homo sapiens_hsa053302.84697873
6Autoimmune thyroid disease_Homo sapiens_hsa053202.71111169
7Leishmaniasis_Homo sapiens_hsa051402.70283742
8Graft-versus-host disease_Homo sapiens_hsa053322.70121661
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69984054
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68734339
11Carbon metabolism_Homo sapiens_hsa012002.62675845
12Osteoclast differentiation_Homo sapiens_hsa043802.51711391
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.36244888
14Asthma_Homo sapiens_hsa053102.35583480
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.30029363
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.15046254
17Pyruvate metabolism_Homo sapiens_hsa006202.11435587
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07121125
19B cell receptor signaling pathway_Homo sapiens_hsa046622.06619136
20Staphylococcus aureus infection_Homo sapiens_hsa051502.05912335
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04604754
22Fatty acid metabolism_Homo sapiens_hsa012122.03278519
23PPAR signaling pathway_Homo sapiens_hsa033201.99616960
24Tuberculosis_Homo sapiens_hsa051521.98854925
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.97980437
26Nitrogen metabolism_Homo sapiens_hsa009101.96013609
27Type I diabetes mellitus_Homo sapiens_hsa049401.95512211
28Ribosome_Homo sapiens_hsa030101.93438764
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85450396
30Primary immunodeficiency_Homo sapiens_hsa053401.79926687
31Influenza A_Homo sapiens_hsa051641.79217641
32Fat digestion and absorption_Homo sapiens_hsa049751.76460550
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76215437
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74883068
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74608169
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74113304
37Sulfur relay system_Homo sapiens_hsa041221.69748495
38Malaria_Homo sapiens_hsa051441.68457194
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68101478
40Herpes simplex infection_Homo sapiens_hsa051681.67518714
41Pentose phosphate pathway_Homo sapiens_hsa000301.65807646
42Biosynthesis of amino acids_Homo sapiens_hsa012301.64963990
43Other glycan degradation_Homo sapiens_hsa005111.64316219
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.59115957
45Measles_Homo sapiens_hsa051621.58979414
46TNF signaling pathway_Homo sapiens_hsa046681.56051789
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53473124
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.49477677
49Hepatitis C_Homo sapiens_hsa051601.46353676
50Selenocompound metabolism_Homo sapiens_hsa004501.45839108
51Arginine biosynthesis_Homo sapiens_hsa002201.41676007
52Caffeine metabolism_Homo sapiens_hsa002321.40807236
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.40574770
54Hematopoietic cell lineage_Homo sapiens_hsa046401.38087631
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35230485
56Lysosome_Homo sapiens_hsa041421.33394357
57Sulfur metabolism_Homo sapiens_hsa009201.32995419
58T cell receptor signaling pathway_Homo sapiens_hsa046601.30372689
59Tryptophan metabolism_Homo sapiens_hsa003801.28523536
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28106315
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26268703
62Butanoate metabolism_Homo sapiens_hsa006501.25093688
63Rheumatoid arthritis_Homo sapiens_hsa053231.23422659
64Parkinsons disease_Homo sapiens_hsa050121.20597785
65Fatty acid biosynthesis_Homo sapiens_hsa000611.19959646
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18604526
67Adipocytokine signaling pathway_Homo sapiens_hsa049201.14351621
68beta-Alanine metabolism_Homo sapiens_hsa004101.11947396
69Fructose and mannose metabolism_Homo sapiens_hsa000511.08906502
70Glutathione metabolism_Homo sapiens_hsa004801.08603006
71Glycerolipid metabolism_Homo sapiens_hsa005611.08396004
72African trypanosomiasis_Homo sapiens_hsa051431.07028756
73Primary bile acid biosynthesis_Homo sapiens_hsa001201.06785322
74Peroxisome_Homo sapiens_hsa041461.02576943
75Glycosaminoglycan degradation_Homo sapiens_hsa005311.00568035
76Bladder cancer_Homo sapiens_hsa052190.98968012
77Non-small cell lung cancer_Homo sapiens_hsa052230.97582530
78Starch and sucrose metabolism_Homo sapiens_hsa005000.96844145
79Cardiac muscle contraction_Homo sapiens_hsa042600.95736541
80Chemokine signaling pathway_Homo sapiens_hsa040620.95675702
81Hepatitis B_Homo sapiens_hsa051610.94704478
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93822979
83Bile secretion_Homo sapiens_hsa049760.93682873
84Insulin resistance_Homo sapiens_hsa049310.92618949
85Oxidative phosphorylation_Homo sapiens_hsa001900.92383946
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.90653036
87AMPK signaling pathway_Homo sapiens_hsa041520.89367617
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88345040
89Folate biosynthesis_Homo sapiens_hsa007900.87933802
90Galactose metabolism_Homo sapiens_hsa000520.86442781
91Regulation of autophagy_Homo sapiens_hsa041400.86042847
92Pertussis_Homo sapiens_hsa051330.85224588
93Thyroid cancer_Homo sapiens_hsa052160.83913601
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.82491295
95Epstein-Barr virus infection_Homo sapiens_hsa051690.80758804
96Insulin signaling pathway_Homo sapiens_hsa049100.78429223
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.77620830
98Pancreatic cancer_Homo sapiens_hsa052120.77508888
99* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76139481
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75532760
101Alzheimers disease_Homo sapiens_hsa050100.71462378
102Phagosome_Homo sapiens_hsa041450.71369893
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70789463
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.68735683
105Salmonella infection_Homo sapiens_hsa051320.68299459
106VEGF signaling pathway_Homo sapiens_hsa043700.67951385
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67253491
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67235210
109Protein digestion and absorption_Homo sapiens_hsa049740.66095761
110Huntingtons disease_Homo sapiens_hsa050160.63991526
111Glucagon signaling pathway_Homo sapiens_hsa049220.60240188
112Phenylalanine metabolism_Homo sapiens_hsa003600.60235431
113Platelet activation_Homo sapiens_hsa046110.59044013
114FoxO signaling pathway_Homo sapiens_hsa040680.58786134
115Chronic myeloid leukemia_Homo sapiens_hsa052200.56527954
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56230691
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55065371
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54494846
119Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53887739
120Legionellosis_Homo sapiens_hsa051340.53084287
121Prolactin signaling pathway_Homo sapiens_hsa049170.52881281
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52404895
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49218195
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48865649
125Renin-angiotensin system_Homo sapiens_hsa046140.48755868
126Small cell lung cancer_Homo sapiens_hsa052220.47070871
127mTOR signaling pathway_Homo sapiens_hsa041500.46860064
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46564943
129Chemical carcinogenesis_Homo sapiens_hsa052040.46433342
130Systemic lupus erythematosus_Homo sapiens_hsa053220.46360655
131Arginine and proline metabolism_Homo sapiens_hsa003300.46116985
132HTLV-I infection_Homo sapiens_hsa051660.45673870
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45194610
134Antigen processing and presentation_Homo sapiens_hsa046120.44938596
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44917867
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44817286
137HIF-1 signaling pathway_Homo sapiens_hsa040660.44622767
138Shigellosis_Homo sapiens_hsa051310.44486044
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.44442635
140Endocytosis_Homo sapiens_hsa041440.43864528
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43862576
142Acute myeloid leukemia_Homo sapiens_hsa052210.42994713
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41240654
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41015319
145Proteoglycans in cancer_Homo sapiens_hsa052050.38483174
146DNA replication_Homo sapiens_hsa030300.38464204
147Viral carcinogenesis_Homo sapiens_hsa052030.38458409
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.37785407
149Pancreatic secretion_Homo sapiens_hsa049720.37639679
150Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37257924
151Focal adhesion_Homo sapiens_hsa045100.36573070
152Collecting duct acid secretion_Homo sapiens_hsa049660.36488740
153Viral myocarditis_Homo sapiens_hsa054160.35432760
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34626266
155Amoebiasis_Homo sapiens_hsa051460.33860120
156Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33534060
157Complement and coagulation cascades_Homo sapiens_hsa046100.33166015
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33085257
159Lysine degradation_Homo sapiens_hsa003100.33064998
160Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32556134
161Metabolic pathways_Homo sapiens_hsa011000.31876235
162Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30892501
163alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30517098
164Toxoplasmosis_Homo sapiens_hsa051450.30486853
165Arachidonic acid metabolism_Homo sapiens_hsa005900.30359648
166ECM-receptor interaction_Homo sapiens_hsa045120.29416755
167Neurotrophin signaling pathway_Homo sapiens_hsa047220.28671386
168Apoptosis_Homo sapiens_hsa042100.27050606
169Inositol phosphate metabolism_Homo sapiens_hsa005620.26888450

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