BAG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.01772793
2DNA deamination (GO:0045006)4.87521824
3DNA strand elongation involved in DNA replication (GO:0006271)4.73705966
4DNA strand elongation (GO:0022616)4.57603014
5IMP biosynthetic process (GO:0006188)4.48622730
6telomere maintenance via semi-conservative replication (GO:0032201)4.44535087
7DNA replication initiation (GO:0006270)4.35252471
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.31295522
9DNA unwinding involved in DNA replication (GO:0006268)4.26232279
10nucleobase biosynthetic process (GO:0046112)4.21798788
11formation of translation preinitiation complex (GO:0001731)4.20696158
12nuclear pore complex assembly (GO:0051292)4.13664180
13IMP metabolic process (GO:0046040)4.12206151
14ribosome assembly (GO:0042255)4.10680054
15purine nucleobase biosynthetic process (GO:0009113)4.04897294
16viral transcription (GO:0019083)3.96074149
17pseudouridine synthesis (GO:0001522)3.93276470
18translational termination (GO:0006415)3.93238554
19nuclear pore organization (GO:0006999)3.92492736
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.89094527
21folic acid-containing compound biosynthetic process (GO:0009396)3.87618293
22maturation of SSU-rRNA (GO:0030490)3.84759251
23translational elongation (GO:0006414)3.77374193
24telomere maintenance via recombination (GO:0000722)3.76450984
25cotranslational protein targeting to membrane (GO:0006613)3.76011030
26protein targeting to ER (GO:0045047)3.75678698
27oxidative phosphorylation (GO:0006119)3.66005873
28proteasome assembly (GO:0043248)3.63454113
29nucleobase-containing small molecule interconversion (GO:0015949)3.61327447
30purine-containing compound salvage (GO:0043101)3.58633813
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57237422
32protein localization to endoplasmic reticulum (GO:0070972)3.55680654
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55018374
34deoxyribonucleotide biosynthetic process (GO:0009263)3.54233561
35translational initiation (GO:0006413)3.43300583
36mitotic metaphase plate congression (GO:0007080)3.43139321
37mitotic sister chromatid segregation (GO:0000070)3.39039094
38telomere maintenance via telomere lengthening (GO:0010833)3.38734861
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.38036505
40deoxyribose phosphate biosynthetic process (GO:0046385)3.38036505
41mitotic recombination (GO:0006312)3.36453840
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33163707
43heme biosynthetic process (GO:0006783)3.28024391
44DNA replication checkpoint (GO:0000076)3.27782282
45mitotic chromosome condensation (GO:0007076)3.25469768
46cullin deneddylation (GO:0010388)3.24665038
47spliceosomal snRNP assembly (GO:0000387)3.24537736
48translation (GO:0006412)3.24505980
49pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.23822648
50protein deneddylation (GO:0000338)3.22053092
51protein localization to chromosome, centromeric region (GO:0071459)3.21541695
52regulation of translational fidelity (GO:0006450)3.20942086
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19033932
54ATP synthesis coupled proton transport (GO:0015986)3.19033932
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.18171567
56cellular protein complex disassembly (GO:0043624)3.16342428
57ribosomal small subunit biogenesis (GO:0042274)3.15779078
58regulation of mitotic spindle organization (GO:0060236)3.13972273
59CENP-A containing nucleosome assembly (GO:0034080)3.13087691
60viral life cycle (GO:0019058)3.12792401
61ventricular cardiac muscle cell development (GO:0055015)3.11769492
62purine nucleotide salvage (GO:0032261)3.11617732
63Golgi transport vesicle coating (GO:0048200)3.11476870
64COPI coating of Golgi vesicle (GO:0048205)3.11476870
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08690947
66collagen fibril organization (GO:0030199)3.08264919
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08193721
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08149409
69negative regulation of ligase activity (GO:0051352)3.08149409
70sister chromatid segregation (GO:0000819)3.05712597
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04850514
72G1/S transition of mitotic cell cycle (GO:0000082)3.04022543
73cell cycle G1/S phase transition (GO:0044843)3.04022543
74establishment of integrated proviral latency (GO:0075713)3.03568219
75ribosomal large subunit biogenesis (GO:0042273)3.02738805
76nucleotide-sugar biosynthetic process (GO:0009226)3.02720613
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.02651957
78ribonucleoprotein complex biogenesis (GO:0022613)2.98940869
79metaphase plate congression (GO:0051310)2.98613441
80ribosome biogenesis (GO:0042254)2.97625731
81regulation of spindle organization (GO:0090224)2.97543689
82guanosine-containing compound biosynthetic process (GO:1901070)2.97440121
83regulation of mitochondrial translation (GO:0070129)2.96417728
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94277098
85chromatin remodeling at centromere (GO:0031055)2.93752749
86pteridine-containing compound biosynthetic process (GO:0042559)2.93733636
87L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92914903
88viral mRNA export from host cell nucleus (GO:0046784)2.92878406
89regulation of translational termination (GO:0006449)2.92779399
90pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.92403915
91mitotic nuclear envelope disassembly (GO:0007077)2.91758218
92regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91654479
93heart contraction (GO:0060047)2.90373450
94heart process (GO:0003015)2.90373450
95protein localization to kinetochore (GO:0034501)2.89078341
96tricarboxylic acid cycle (GO:0006099)2.88837041
97signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88374651
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88374651
99pore complex assembly (GO:0046931)2.86590577
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86563720
101DNA replication-dependent nucleosome assembly (GO:0006335)2.84835627
102DNA replication-dependent nucleosome organization (GO:0034723)2.84835627
103de novo protein folding (GO:0006458)2.83727331
104regulation of cellular amino acid metabolic process (GO:0006521)2.83527205
105protein complex disassembly (GO:0043241)2.83454799
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82652096
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82652096
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82652096
109protein maturation by protein folding (GO:0022417)2.82335461
110regulation of protein heterodimerization activity (GO:0043497)2.80320752
111de novo posttranslational protein folding (GO:0051084)2.79617314
112rRNA processing (GO:0006364)2.79051339
113AMP metabolic process (GO:0046033)2.78687699
114actin-myosin filament sliding (GO:0033275)2.78678216
115muscle filament sliding (GO:0030049)2.78678216
116tRNA aminoacylation for protein translation (GO:0006418)2.77779461
117UDP-N-acetylglucosamine metabolic process (GO:0006047)2.77661096
118amino acid activation (GO:0043038)2.76949373
119tRNA aminoacylation (GO:0043039)2.76949373
120mesenchymal-epithelial cell signaling (GO:0060638)2.74785490
121membrane disassembly (GO:0030397)2.74643170
122nuclear envelope disassembly (GO:0051081)2.74643170
123mitotic sister chromatid cohesion (GO:0007064)2.74282713
124rRNA methylation (GO:0031167)2.73668164
125COPII vesicle coating (GO:0048208)2.73195003
126establishment of viral latency (GO:0019043)2.72115253
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71184770
128establishment of chromosome localization (GO:0051303)2.64818697
129rRNA modification (GO:0000154)2.63664966
130tetrahydrofolate metabolic process (GO:0046653)2.59235033
131regulation of translational elongation (GO:0006448)2.53647780
132maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.51039987
133non-recombinational repair (GO:0000726)2.50700234
134double-strand break repair via nonhomologous end joining (GO:0006303)2.50700234
135positive regulation of chromosome segregation (GO:0051984)2.48756451
136sequestering of extracellular ligand from receptor (GO:0035581)2.47488159
137kidney mesenchyme development (GO:0072074)2.45906429
138protein retention in ER lumen (GO:0006621)2.44785606
139positive regulation of actin filament depolymerization (GO:0030836)2.43296618
140cellular protein complex localization (GO:0034629)2.39889769
141regulation of chromosome segregation (GO:0051983)2.39519272
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.39363952
143mitotic nuclear envelope reassembly (GO:0007084)2.36225522
144nuclear envelope reassembly (GO:0031468)2.36225522
145pteridine-containing compound metabolic process (GO:0042558)2.35922461
146protein hydroxylation (GO:0018126)2.35041968
147spindle checkpoint (GO:0031577)2.34407022
148meiotic chromosome segregation (GO:0045132)2.33967543
149positive regulation of mitotic sister chromatid separation (GO:1901970)2.33481491
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.33481491
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.33481491
152positive regulation of ligase activity (GO:0051351)2.32872805
153mitochondrial RNA metabolic process (GO:0000959)2.32326370
154negative regulation of DNA repair (GO:0045738)2.32255933
155type B pancreatic cell proliferation (GO:0044342)2.31416797

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.27183801
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.13743344
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.72594771
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68266273
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.27170561
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.17578379
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17241178
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.12911604
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.99060825
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92836126
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.87832120
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85233531
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77440469
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74527476
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50371466
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.48453132
17XRN2_22483619_ChIP-Seq_HELA_Human2.46613726
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41049179
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37134359
20* DCP1A_22483619_ChIP-Seq_HELA_Human2.26992540
21VDR_23849224_ChIP-Seq_CD4+_Human2.25248725
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24495735
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21901231
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14240587
25GABP_19822575_ChIP-Seq_HepG2_Human2.13787255
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.11681071
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10970316
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.09446391
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06011469
30TRIM28_21343339_ChIP-Seq_HEK293_Human2.04096516
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03475267
32FOXP3_21729870_ChIP-Seq_TREG_Human2.01607721
33AR_21909140_ChIP-Seq_LNCAP_Human2.01100502
34* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.98265107
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93985487
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.93611869
37ELK1_19687146_ChIP-ChIP_HELA_Human1.91860097
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.89789304
39TTF2_22483619_ChIP-Seq_HELA_Human1.89195368
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.87981981
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.87956368
42BRD4_25478319_ChIP-Seq_HGPS_Human1.83822548
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79345560
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77408544
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74436904
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74313915
47* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72559234
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66287826
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63578810
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.59582973
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.58519575
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56202660
53MYC_22102868_ChIP-Seq_BL_Human1.52029976
54CIITA_25753668_ChIP-Seq_RAJI_Human1.49928296
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49377519
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49257942
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48669606
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47811938
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46289228
60* SOX17_20123909_ChIP-Seq_XEN_Mouse1.44032125
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.38340054
62GATA1_22025678_ChIP-Seq_K562_Human1.37908984
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.35905468
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31596157
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28400516
66DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27209593
67TFEB_21752829_ChIP-Seq_HELA_Human1.26793772
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26737685
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25877903
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.25481185
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25415541
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23262179
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22212047
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.21474679
75NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21454222
76CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20996738
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.20632772
78EGR1_19374776_ChIP-ChIP_THP-1_Human1.20103205
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.19776358
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17936971
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17383520
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17319358
83KDM5A_27292631_Chip-Seq_BREAST_Human1.16223228
84ZNF263_19887448_ChIP-Seq_K562_Human1.16104492
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12620854
86PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11570201
87MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11500500
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08296845
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07443195
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06983805
91* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06877189
92* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06483890
93ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06399055
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06083400
95* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05629489
96VDR_21846776_ChIP-Seq_THP-1_Human1.05536348
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04751703
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02399372
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01864615
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00603943
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00061559
102* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97348176
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96279355
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96082667
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96082667
106NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95263225
107MYC_18940864_ChIP-ChIP_HL60_Human0.94531457
108* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91869838
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91612758
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91252856
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91046218
112CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89974024
113* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89484817
114CLOCK_20551151_ChIP-Seq_293T_Human0.89109403
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87942101
116* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87612760
117CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86957645
118RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86720176
119SPI1_23547873_ChIP-Seq_NB4_Human0.86354075
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86319465
121NANOG_16153702_ChIP-ChIP_HESCs_Human0.86267786
122BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86083596
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85213138
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83424479
125FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81001667
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80658775
127FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80350235
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80308791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.62373354
2MP0003693_abnormal_embryo_hatching3.58216868
3MP0004084_abnormal_cardiac_muscle3.19267852
4MP0003950_abnormal_plasma_membrane3.19160504
5MP0004957_abnormal_blastocyst_morpholog3.04198398
6MP0002396_abnormal_hematopoietic_system3.02126240
7MP0000749_muscle_degeneration2.96846069
8MP0004147_increased_porphyrin_level2.95990817
9MP0010094_abnormal_chromosome_stability2.79104227
10MP0008007_abnormal_cellular_replicative2.48246012
11MP0003077_abnormal_cell_cycle2.47992129
12MP0003123_paternal_imprinting2.44952327
13MP0003111_abnormal_nucleus_morphology2.33400813
14MP0009697_abnormal_copulation2.21888271
15MP0005623_abnormal_meninges_morphology2.19508153
16MP0004215_abnormal_myocardial_fiber2.19067923
17MP0008438_abnormal_cutaneous_collagen2.12033494
18MP0001661_extended_life_span2.09429730
19MP0003656_abnormal_erythrocyte_physiolo2.08211694
20MP0008058_abnormal_DNA_repair2.04214967
21MP0002837_dystrophic_cardiac_calcinosis2.00791453
22MP0008932_abnormal_embryonic_tissue2.00453010
23MP0006036_abnormal_mitochondrial_physio1.98183211
24MP0005330_cardiomyopathy1.95271421
25MP0003221_abnormal_cardiomyocyte_apopto1.93920970
26MP0005257_abnormal_intraocular_pressure1.91499182
27MP0000750_abnormal_muscle_regeneration1.83265256
28MP0010352_gastrointestinal_tract_polyps1.83074761
29MP0003941_abnormal_skin_development1.80533103
30MP0008775_abnormal_heart_ventricle1.79940560
31MP0001542_abnormal_bone_strength1.79770507
32MP0009780_abnormal_chondrocyte_physiolo1.79704947
33MP0004808_abnormal_hematopoietic_stem1.79465081
34MP0004036_abnormal_muscle_relaxation1.73436491
35MP0008057_abnormal_DNA_replication1.71691947
36MP0003279_aneurysm1.70832587
37MP0003567_abnormal_fetal_cardiomyocyte1.68696146
38MP0000751_myopathy1.58761807
39MP0001958_emphysema1.54907022
40MP0000490_abnormal_crypts_of1.54896173
41MP0001730_embryonic_growth_arrest1.53914919
42MP0001545_abnormal_hematopoietic_system1.52538844
43MP0005397_hematopoietic_system_phenotyp1.52538844
44MP0005503_abnormal_tendon_morphology1.52324009
45MP0003806_abnormal_nucleotide_metabolis1.47974404
46MP0006035_abnormal_mitochondrial_morpho1.46580563
47MP0002060_abnormal_skin_morphology1.43929334
48MP0002269_muscular_atrophy1.43597478
49MP0004087_abnormal_muscle_fiber1.42698889
50MP0010630_abnormal_cardiac_muscle1.41520885
51MP0000350_abnormal_cell_proliferation1.40191138
52MP0001299_abnormal_eye_distance/1.40170769
53MP0003646_muscle_fatigue1.39478694
54MP0002972_abnormal_cardiac_muscle1.39311515
55MP0000358_abnormal_cell_content/1.38269555
56MP0010368_abnormal_lymphatic_system1.37576239
57MP0003186_abnormal_redox_activity1.35830534
58MP0002108_abnormal_muscle_morphology1.35343385
59MP0009379_abnormal_foot_pigmentation1.33589198
60MP0001697_abnormal_embryo_size1.28488669
61MP0004233_abnormal_muscle_weight1.24898933
62MP0002080_prenatal_lethality1.24196799
63MP0009333_abnormal_splenocyte_physiolog1.23797938
64MP0001544_abnormal_cardiovascular_syste1.21765713
65MP0005385_cardiovascular_system_phenoty1.21765713
66MP0003984_embryonic_growth_retardation1.20409206
67MP0001348_abnormal_lacrimal_gland1.16896833
68MP0005620_abnormal_muscle_contractility1.16337577
69MP0002088_abnormal_embryonic_growth/wei1.16247175
70MP0010030_abnormal_orbit_morphology1.16133690
71MP0006138_congestive_heart_failure1.15701908
72MP0003566_abnormal_cell_adhesion1.15484141
73MP0000313_abnormal_cell_death1.14482677
74MP0000003_abnormal_adipose_tissue1.14031527
75MP0009250_abnormal_appendicular_skeleto1.13746298
76MP0000759_abnormal_skeletal_muscle1.13680774
77MP0003937_abnormal_limbs/digits/tail_de1.09515644
78MP0002295_abnormal_pulmonary_circulatio1.09237645
79MP0000733_abnormal_muscle_development1.08879204
80MP0002106_abnormal_muscle_physiology1.07418326
81MP0001672_abnormal_embryogenesis/_devel1.05522763
82MP0005380_embryogenesis_phenotype1.05522763
83MP0000767_abnormal_smooth_muscle1.05037325
84MP0003786_premature_aging1.03203960
85MP0003385_abnormal_body_wall1.01737760
86MP0003718_maternal_effect1.01446464
87MP0005508_abnormal_skeleton_morphology1.00520018
88MP0003942_abnormal_urinary_system0.98609009
89MP0003122_maternal_imprinting0.98287843
90MP0004272_abnormal_basement_membrane0.98131607
91MP0003121_genomic_imprinting0.97148153
92MP0002019_abnormal_tumor_incidence0.96058462
93MP0000747_muscle_weakness0.94514319
94MP0000428_abnormal_craniofacial_morphol0.93943775
95MP0000858_altered_metastatic_potential0.92244969
96MP0000266_abnormal_heart_morphology0.90857854
97MP0005369_muscle_phenotype0.90517970
98MP0010386_abnormal_urinary_bladder0.90230157
99MP0003091_abnormal_cell_migration0.89646901
100MP0005023_abnormal_wound_healing0.88990055
101MP0002938_white_spotting0.88684865
102MP0009384_cardiac_valve_regurgitation0.88632553
103MP0010307_abnormal_tumor_latency0.88282558
104MP0005275_abnormal_skin_tensile0.85049962
105MP0000762_abnormal_tongue_morphology0.84545250
106MP0000343_altered_response_to0.84135575
107MP0009053_abnormal_anal_canal0.83537694
108MP0002877_abnormal_melanocyte_morpholog0.82379308
109MP0003137_abnormal_impulse_conducting0.82310395
110MP0003828_pulmonary_edema0.82149652
111MP0002086_abnormal_extraembryonic_tissu0.81587977
112MP0005171_absent_coat_pigmentation0.81228572
113MP0002132_abnormal_respiratory_system0.81090090
114MP0000013_abnormal_adipose_tissue0.80311144
115MP0002085_abnormal_embryonic_tissue0.79472472
116MP0002160_abnormal_reproductive_system0.79087377
117MP0004197_abnormal_fetal_growth/weight/0.78380265
118MP0005266_abnormal_metabolism0.77159856
119MP0003705_abnormal_hypodermis_morpholog0.76302142
120MP0002127_abnormal_cardiovascular_syste0.74188776
121MP0004134_abnormal_chest_morphology0.73548447
122MP0002084_abnormal_developmental_patter0.72596757
123MP0005395_other_phenotype0.71373988
124MP0005165_increased_susceptibility_to0.71139703
125MP0001243_abnormal_dermal_layer0.70922680
126MP0002089_abnormal_postnatal_growth/wei0.69413436
127MP0002114_abnormal_axial_skeleton0.69303941
128MP0001915_intracranial_hemorrhage0.68702364
129MP0002128_abnormal_blood_circulation0.68516075
130MP0005384_cellular_phenotype0.66218951
131MP0000534_abnormal_ureter_morphology0.65853043
132MP0004185_abnormal_adipocyte_glucose0.65606052
133MP0005220_abnormal_exocrine_pancreas0.65322316
134MP0004145_abnormal_muscle_electrophysio0.64956317
135MP0001879_abnormal_lymphatic_vessel0.64775468
136MP0005621_abnormal_cell_physiology0.63799531
137MP0002896_abnormal_bone_mineralization0.61928290

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.90458111
2Abnormality of cells of the erythroid lineage (HP:0012130)4.72643797
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.61129366
4Aplastic anemia (HP:0001915)3.82982929
5Aortic dissection (HP:0002647)3.65867573
6Hepatocellular necrosis (HP:0001404)3.52951006
7Abnormal mitochondria in muscle tissue (HP:0008316)3.49589265
8Hepatic necrosis (HP:0002605)3.42010629
9Ankle contracture (HP:0006466)3.38605112
10Acute necrotizing encephalopathy (HP:0006965)3.36514383
11Protrusio acetabuli (HP:0003179)3.35352458
12Mitochondrial inheritance (HP:0001427)3.30438088
13Increased CSF lactate (HP:0002490)3.25412170
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23789606
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23789606
16Reticulocytopenia (HP:0001896)3.12886448
17Exercise intolerance (HP:0003546)3.02766602
18Microretrognathia (HP:0000308)2.83804459
19Birth length less than 3rd percentile (HP:0003561)2.83090372
20Exercise-induced muscle cramps (HP:0003710)2.81633276
21Increased serum lactate (HP:0002151)2.77533755
22Reduced subcutaneous adipose tissue (HP:0003758)2.69385711
23Thrombocytosis (HP:0001894)2.68924993
24Selective tooth agenesis (HP:0001592)2.68630339
25Abnormality of glycolysis (HP:0004366)2.68427909
26Increased serum pyruvate (HP:0003542)2.68427909
27Lipoatrophy (HP:0100578)2.68404255
28Spinal rigidity (HP:0003306)2.68243286
29Osteolytic defects of the hand bones (HP:0009699)2.66880687
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.66880687
31Bladder diverticulum (HP:0000015)2.66702139
32Ragged-red muscle fibers (HP:0003200)2.66462976
33Follicular hyperkeratosis (HP:0007502)2.64773716
34Calcaneovalgus deformity (HP:0001848)2.63526548
35Increased hepatocellular lipid droplets (HP:0006565)2.62694475
36Acute encephalopathy (HP:0006846)2.61936730
37Palpitations (HP:0001962)2.61716296
38Chromsome breakage (HP:0040012)2.60369351
39Elbow flexion contracture (HP:0002987)2.59703491
40Lipid accumulation in hepatocytes (HP:0006561)2.59127639
41Entropion (HP:0000621)2.59035901
42Increased intramyocellular lipid droplets (HP:0012240)2.58041647
43Abnormality of dentin (HP:0010299)2.57423452
44Rhabdomyolysis (HP:0003201)2.55738438
45Redundant skin (HP:0001582)2.53386425
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52339793
47Abnormality of the calcaneus (HP:0008364)2.50544086
4811 pairs of ribs (HP:0000878)2.50498144
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50446614
50Progressive macrocephaly (HP:0004481)2.50292443
51Abnormality of the umbilical cord (HP:0010881)2.49449387
52Type I transferrin isoform profile (HP:0003642)2.45358479
53Vertebral compression fractures (HP:0002953)2.44865504
54Wormian bones (HP:0002645)2.44405885
55Increased muscle lipid content (HP:0009058)2.43398513
56Ventricular tachycardia (HP:0004756)2.41195693
57Abnormal delivery (HP:0001787)2.39606947
58Pallor (HP:0000980)2.36742748
59Bowel diverticulosis (HP:0005222)2.36640364
60Breech presentation (HP:0001623)2.36277537
61Oral leukoplakia (HP:0002745)2.35731698
62Deformed tarsal bones (HP:0008119)2.35708912
63Myoglobinuria (HP:0002913)2.35381268
64Lactic acidosis (HP:0003128)2.34477827
65Hypoplasia of the pons (HP:0012110)2.31556383
66Exertional dyspnea (HP:0002875)2.30996273
67Vascular tortuosity (HP:0004948)2.28823860
68Abnormality of alanine metabolism (HP:0010916)2.28109462
69Hyperalaninemia (HP:0003348)2.28109462
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.28109462
71Colon cancer (HP:0003003)2.25524963
72Abnormality of the intrinsic pathway (HP:0010989)2.23728210
73Mesomelia (HP:0003027)2.23402831
74Microglossia (HP:0000171)2.22941897
75Short middle phalanx of the 5th finger (HP:0004220)2.21527809
76Respiratory failure (HP:0002878)2.20531637
77Abnormalities of placenta or umbilical cord (HP:0001194)2.19830294
78Fragile skin (HP:0001030)2.19774683
79Macrocytic anemia (HP:0001972)2.19614950
80Subaortic stenosis (HP:0001682)2.19355130
81Abnormality of the left ventricular outflow tract (HP:0011103)2.19355130
82Slender long bone (HP:0003100)2.19238733
83Progressive muscle weakness (HP:0003323)2.19073715
84Round ear (HP:0100830)2.18072883
85Abnormality of placental membranes (HP:0011409)2.17930933
86Amniotic constriction ring (HP:0009775)2.17930933
87Decreased subcutaneous fat (HP:0001002)2.16289066
88Delayed gross motor development (HP:0002194)2.15732226
89Dilated cardiomyopathy (HP:0001644)2.14391061
90Cervical subluxation (HP:0003308)2.12714576
91Cardiovascular calcification (HP:0011915)2.10683648
92Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.10066476
93Generalized amyotrophy (HP:0003700)2.09998643
94Multiple enchondromatosis (HP:0005701)2.08899836
95Trismus (HP:0000211)2.08536480
96Abnormal protein glycosylation (HP:0012346)2.07220946
97Abnormal glycosylation (HP:0012345)2.07220946
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07220946
99Abnormal protein N-linked glycosylation (HP:0012347)2.07220946
100Premature rupture of membranes (HP:0001788)2.06046644
101Esophageal neoplasm (HP:0100751)2.06013959
102Neoplasm of head and neck (HP:0012288)2.06013959
103Dilatation of the ascending aorta (HP:0005111)2.05708461
104Broad face (HP:0000283)2.05048575
105Reduced antithrombin III activity (HP:0001976)2.04886067
106Nemaline bodies (HP:0003798)2.02366953
107Abnormality of the anterior horn cell (HP:0006802)2.02255160
108Degeneration of anterior horn cells (HP:0002398)2.02255160
109Abnormality of reticulocytes (HP:0004312)2.01241686
110Respiratory difficulties (HP:0002880)2.01092845
111Abnormal umbilical cord blood vessels (HP:0011403)2.00147820
112Single umbilical artery (HP:0001195)2.00147820
113Abnormality of the fetal cardiovascular system (HP:0010948)2.00147820
114Supraventricular tachycardia (HP:0004755)2.00128779
115Supraventricular arrhythmia (HP:0005115)1.99481386
116Poor head control (HP:0002421)1.99447708
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99261677
118Muscle fiber inclusion bodies (HP:0100299)1.97749481
119Ulnar bowing (HP:0003031)1.97437265
120Abnormality of the pons (HP:0007361)1.94745166
121Slender build (HP:0001533)1.94663438
122Atrophic scars (HP:0001075)1.94392820
123Glucose intolerance (HP:0000833)1.93409332
124Abnormality of subcutaneous fat tissue (HP:0001001)1.93316076
125Increased connective tissue (HP:0009025)1.92548460
126Soft skin (HP:0000977)1.92538357
127Cutaneous melanoma (HP:0012056)1.92070241
128Short nail (HP:0001799)1.91142017
129Neoplasm of the adrenal gland (HP:0100631)1.90817754
130Type 1 muscle fiber predominance (HP:0003803)1.88088194
131Distal arthrogryposis (HP:0005684)1.87153729
132Increased density of long bones (HP:0006392)1.86629546
133Spondylolisthesis (HP:0003302)1.86592911
134Coronal craniosynostosis (HP:0004440)1.86120321
135Biconcave vertebral bodies (HP:0004586)1.86026386
136Genu recurvatum (HP:0002816)1.85257264
137Aortic aneurysm (HP:0004942)1.84972519
138Atrial fibrillation (HP:0005110)1.84060339
139Blue sclerae (HP:0000592)1.84050924
140Aplasia of the musculature (HP:0100854)1.83748996
141Nonimmune hydrops fetalis (HP:0001790)1.83517918
142Abnormality of the tricuspid valve (HP:0001702)1.82495326
143Patent foramen ovale (HP:0001655)1.82210726
144Knee flexion contracture (HP:0006380)1.79917821
145Sudden death (HP:0001699)1.79412653
146Abnormality of the acetabulum (HP:0003170)1.78660266
147Rough bone trabeculation (HP:0100670)1.77435612
148Sensory axonal neuropathy (HP:0003390)1.76682886
149Renal duplication (HP:0000075)1.76360031
150Myotonia (HP:0002486)1.75884515
151Mesangial abnormality (HP:0001966)1.75793378
152Abnormality of the calf musculature (HP:0001430)1.75577579
153Primary atrial arrhythmia (HP:0001692)1.75257715
154Limb-girdle muscle atrophy (HP:0003797)1.73989810
155Diaphragmatic weakness (HP:0009113)1.73013182
156Orthostatic hypotension (HP:0001278)1.72724487
157Missing ribs (HP:0000921)1.72652650
158Ulnar deviation of the wrist (HP:0003049)1.72449306
159Delayed cranial suture closure (HP:0000270)1.70845610
160Delayed closure of the anterior fontanelle (HP:0001476)1.70540519
161Microvesicular hepatic steatosis (HP:0001414)1.70155145
162Abnormality of methionine metabolism (HP:0010901)1.68885252
163Arterial tortuosity (HP:0005116)1.68413421
164Aplasia/Hypoplasia of the uvula (HP:0010293)1.68285005
165Abnormality of skeletal muscle fiber size (HP:0012084)1.66302815
166Increased variability in muscle fiber diameter (HP:0003557)1.65818178
167Neck muscle weakness (HP:0000467)1.65671403
168Duodenal stenosis (HP:0100867)1.65358627
169Small intestinal stenosis (HP:0012848)1.65358627
170Mildly elevated creatine phosphokinase (HP:0008180)1.62371246
171Limb-girdle muscle weakness (HP:0003325)1.61099454
172Aortic regurgitation (HP:0001659)1.58918615
173Meckel diverticulum (HP:0002245)1.58736698

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.68717695
2NME23.34479739
3EIF2AK13.00228501
4STK162.99061218
5WEE12.98696773
6BUB12.88484661
7BRSK22.79768971
8NEK12.74526700
9EIF2AK32.66652430
10SCYL22.62263379
11CDC72.50302767
12MYLK2.49657449
13FLT32.39899069
14PIM22.38085858
15ACVR1B2.18092332
16TESK12.14768082
17VRK11.98200976
18LIMK11.95342103
19TTN1.95148590
20RPS6KA41.86157795
21PKN21.81349556
22OBSCN1.78815675
23TGFBR11.64068591
24MST1R1.56764242
25CDK81.56029190
26PASK1.55839917
27VRK21.52597446
28TSSK61.51687262
29MKNK11.50462692
30KDR1.50364566
31LATS11.48900137
32MST41.47308970
33BRSK11.46890779
34ERBB41.44503740
35PDK21.44488743
36MAPKAPK31.41614271
37MAP2K31.40003186
38PDGFRA1.30682122
39RPS6KB21.30290468
40ZAK1.23360270
41EEF2K1.19357614
42MET1.17358805
43ILK1.16866756
44MAP3K111.16663141
45TESK21.16557756
46LRRK21.15570463
47CDK71.15432729
48TAF11.15254512
49AURKB1.14684727
50NEK21.09451348
51PTK21.08895842
52MAP3K121.07649733
53SRPK11.06567266
54DYRK31.05146325
55ICK1.02946146
56PAK21.00719808
57CCNB11.00192902
58PIK3CG0.97915396
59AKT30.95689674
60BCKDK0.94786163
61PLK10.93223575
62NME10.92513589
63MELK0.92275548
64DDR20.91550517
65NEK90.91467407
66ATR0.90503898
67PAK40.89968220
68MAP3K80.89346596
69TRIB30.88106771
70PLK30.87816981
71STK240.87212251
72PDK30.85876890
73PDK40.85876890
74PIK3CA0.83839962
75MAP3K100.80804554
76AURKA0.80602906
77STK100.78185328
78MOS0.77758374
79MAP3K30.77059188
80CDK120.76820337
81ARAF0.74223991
82ERBB30.72539328
83NUAK10.71804306
84DMPK0.70982185
85TRPM70.70832253
86CAMKK20.69413714
87PAK10.66522166
88CLK10.63874575
89TEC0.63721460
90TLK10.63258702
91STK38L0.59893587
92PLK20.59868424
93PLK40.59826054
94IRAK30.59667962
95CDK90.58086343
96TTK0.56435040
97CDK40.55735773
98MAPKAPK50.55689237
99TAOK20.55232189
100BTK0.55001526
101ATM0.51850030
102ABL20.51745197
103CSNK2A10.50454809
104MAP3K50.49340790
105BRAF0.49313038
106CSNK2A20.47669326
107KIT0.47442321
108MAPK110.47115449
109STK40.46302386
110RAF10.46169831
111PNCK0.45915043
112DAPK30.45267198
113EPHA20.44376111
114PHKG20.43812037
115PHKG10.43812037
116FRK0.42620610
117RPS6KC10.40613847
118RPS6KL10.40613847
119CHEK10.40218460
120MUSK0.39370361
121ERN10.39038629
122PIM10.38369775
123WNK40.37768112
124RPS6KA60.37385932
125CAMK2D0.37302061
126ROCK10.36972860
127MKNK20.36720361
128AKT20.36118865
129JAK30.34045689
130DAPK10.33894609
131EIF2AK20.32764988
132LMTK20.32603312
133STK30.27193676
134ZAP700.25321944
135LATS20.25063080
136CHEK20.24160505

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91847637
2Ribosome_Homo sapiens_hsa030103.73476098
3Proteasome_Homo sapiens_hsa030503.57494206
4Mismatch repair_Homo sapiens_hsa034303.45681531
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.02647015
6RNA polymerase_Homo sapiens_hsa030202.64005837
7Base excision repair_Homo sapiens_hsa034102.61620957
8Nucleotide excision repair_Homo sapiens_hsa034202.57922472
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57174982
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53733836
11Pyrimidine metabolism_Homo sapiens_hsa002402.53341057
12Spliceosome_Homo sapiens_hsa030402.44816008
13Protein export_Homo sapiens_hsa030602.26375274
14RNA transport_Homo sapiens_hsa030132.25863940
15One carbon pool by folate_Homo sapiens_hsa006702.22477562
16Parkinsons disease_Homo sapiens_hsa050122.18117745
17Cell cycle_Homo sapiens_hsa041102.15625014
18Homologous recombination_Homo sapiens_hsa034402.10615342
19Oxidative phosphorylation_Homo sapiens_hsa001901.85749833
20Vitamin B6 metabolism_Homo sapiens_hsa007501.72520688
21RNA degradation_Homo sapiens_hsa030181.62969770
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.61840070
23Huntingtons disease_Homo sapiens_hsa050161.58888923
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50074420
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50020721
26Purine metabolism_Homo sapiens_hsa002301.47501521
27Cardiac muscle contraction_Homo sapiens_hsa042601.41329032
28p53 signaling pathway_Homo sapiens_hsa041151.37747395
29Non-homologous end-joining_Homo sapiens_hsa034501.34758344
30N-Glycan biosynthesis_Homo sapiens_hsa005101.29596582
31Carbon metabolism_Homo sapiens_hsa012001.23846583
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19505698
33Alzheimers disease_Homo sapiens_hsa050101.17564042
34Fanconi anemia pathway_Homo sapiens_hsa034601.16274852
35Basal transcription factors_Homo sapiens_hsa030221.11925850
36Biosynthesis of amino acids_Homo sapiens_hsa012301.11897263
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11566169
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10225893
39* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08112444
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03326233
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03202260
42Thyroid cancer_Homo sapiens_hsa052160.99243288
43Pentose phosphate pathway_Homo sapiens_hsa000300.95427577
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92662198
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92020883
46Galactose metabolism_Homo sapiens_hsa000520.91324316
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91255112
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91241421
49Epstein-Barr virus infection_Homo sapiens_hsa051690.89586143
50Sulfur metabolism_Homo sapiens_hsa009200.88926348
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86250989
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86183513
53Dilated cardiomyopathy_Homo sapiens_hsa054140.82013365
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.79253544
55mRNA surveillance pathway_Homo sapiens_hsa030150.77940720
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74892840
57Melanoma_Homo sapiens_hsa052180.74292967
58Viral carcinogenesis_Homo sapiens_hsa052030.71133462
59Folate biosynthesis_Homo sapiens_hsa007900.70782331
60Systemic lupus erythematosus_Homo sapiens_hsa053220.69525015
61Pyruvate metabolism_Homo sapiens_hsa006200.69367225
62Legionellosis_Homo sapiens_hsa051340.67616762
63Selenocompound metabolism_Homo sapiens_hsa004500.67245282
64Bladder cancer_Homo sapiens_hsa052190.66021102
65Small cell lung cancer_Homo sapiens_hsa052220.65133632
66Fatty acid elongation_Homo sapiens_hsa000620.63539831
67Adherens junction_Homo sapiens_hsa045200.63332240
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62937448
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61739416
70Glutathione metabolism_Homo sapiens_hsa004800.61673016
71Sulfur relay system_Homo sapiens_hsa041220.61639284
72Viral myocarditis_Homo sapiens_hsa054160.57531457
73HTLV-I infection_Homo sapiens_hsa051660.55432119
74Antigen processing and presentation_Homo sapiens_hsa046120.53955560
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.52448008
76HIF-1 signaling pathway_Homo sapiens_hsa040660.50687637
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.47651648
78Oocyte meiosis_Homo sapiens_hsa041140.47354159
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47287589
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46745086
81Herpes simplex infection_Homo sapiens_hsa051680.46348604
82Shigellosis_Homo sapiens_hsa051310.45456692
83Hedgehog signaling pathway_Homo sapiens_hsa043400.43754156
84Steroid biosynthesis_Homo sapiens_hsa001000.43080779
85Fructose and mannose metabolism_Homo sapiens_hsa000510.42931070
86Arginine biosynthesis_Homo sapiens_hsa002200.42483101
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42209225
88Metabolic pathways_Homo sapiens_hsa011000.40892218
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37243027
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36712571
91Lysine degradation_Homo sapiens_hsa003100.35778658
92Apoptosis_Homo sapiens_hsa042100.35308715
93Focal adhesion_Homo sapiens_hsa045100.34639014
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33863941
95Fatty acid degradation_Homo sapiens_hsa000710.33319198
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.31872241
97Alcoholism_Homo sapiens_hsa050340.31508712
98Fatty acid metabolism_Homo sapiens_hsa012120.31407182
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30417615
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30019467
101Hepatitis B_Homo sapiens_hsa051610.28297252
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28094775
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27239742
104Chronic myeloid leukemia_Homo sapiens_hsa052200.26641837
105MicroRNAs in cancer_Homo sapiens_hsa052060.26513855
106Wnt signaling pathway_Homo sapiens_hsa043100.26457615
107Basal cell carcinoma_Homo sapiens_hsa052170.26266005
108TGF-beta signaling pathway_Homo sapiens_hsa043500.26060869
109ECM-receptor interaction_Homo sapiens_hsa045120.25953655
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22279686
111Renin-angiotensin system_Homo sapiens_hsa046140.17930413
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17091722
113Proteoglycans in cancer_Homo sapiens_hsa052050.15713263
114Arginine and proline metabolism_Homo sapiens_hsa003300.15230137
115Hematopoietic cell lineage_Homo sapiens_hsa046400.14617095
116Colorectal cancer_Homo sapiens_hsa052100.14602211
117Hippo signaling pathway_Homo sapiens_hsa043900.13872123
118Propanoate metabolism_Homo sapiens_hsa006400.12577220
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12393756
120Vibrio cholerae infection_Homo sapiens_hsa051100.11966205
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11806258
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10939515
123Measles_Homo sapiens_hsa051620.10906542

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »