ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pseudouridine synthesis (GO:0001522)	6.05445656
2	negative regulation of execution phase of apoptosis (GO:1900118)	5.45943650
3	glycerophospholipid catabolic process (GO:0046475)	4.96705758
4	ribonucleoprotein complex disassembly (GO:0032988)	4.85183303
5	facial nerve structural organization (GO:0021612)	4.80560081
6	protein prenylation (GO:0018342)	4.73102022
7	prenylation (GO:0097354)	4.73102022
8	DNA double-strand break processing (GO:0000729)	4.64181351
9	synaptic transmission, cholinergic (GO:0007271)	4.39015488
10	negative regulation of T cell receptor signaling pathway (GO:0050860)	4.21597493
11	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	4.17137169
12	fucose catabolic process (GO:0019317)	4.16370198
13	L-fucose metabolic process (GO:0042354)	4.16370198
14	L-fucose catabolic process (GO:0042355)	4.16370198
15	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.09910895
16	parturition (GO:0007567)	4.05468840
17	glial cell proliferation (GO:0014009)	4.03560750
18	chemosensory behavior (GO:0007635)	4.03019607
19	organelle disassembly (GO:1903008)	3.98005896
20	DNA deamination (GO:0045006)	3.93974124
21	neural tube formation (GO:0001841)	3.92048894
22	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.86749446
23	DNA damage response, detection of DNA damage (GO:0042769)	3.84597889
24	indolalkylamine metabolic process (GO:0006586)	3.83903219
25	behavioral response to nicotine (GO:0035095)	3.74985345
26	cranial nerve structural organization (GO:0021604)	3.68633065
27	coenzyme A metabolic process (GO:0015936)	3.67694579
28	limb bud formation (GO:0060174)	3.66648756
29	regulation of mitotic spindle organization (GO:0060236)	3.60457912
30	platelet dense granule organization (GO:0060155)	3.56073658
31	phenylpropanoid metabolic process (GO:0009698)	3.55514456
32	establishment of mitochondrion localization (GO:0051654)	3.54839111
33	regulation of development, heterochronic (GO:0040034)	3.53842223
34	cytolysis (GO:0019835)	3.50497655
35	ribosomal small subunit assembly (GO:0000028)	3.33884617
36	DNA ligation (GO:0006266)	3.33626454
37	metallo-sulfur cluster assembly (GO:0031163)	3.33545376
38	iron-sulfur cluster assembly (GO:0016226)	3.33545376
39	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.33031199
40	tryptophan catabolic process (GO:0006569)	3.32990387
41	indole-containing compound catabolic process (GO:0042436)	3.32990387
42	indolalkylamine catabolic process (GO:0046218)	3.32990387
43	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.29071911
44	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.27055379
45	regulation of timing of cell differentiation (GO:0048505)	3.26411789
46	pyrimidine nucleobase catabolic process (GO:0006208)	3.24819804
47	tryptophan metabolic process (GO:0006568)	3.24231128
48	cell wall macromolecule catabolic process (GO:0016998)	3.24048011
49	behavioral response to ethanol (GO:0048149)	3.23312138
50	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.16601585
51	regulation of male gonad development (GO:2000018)	3.15294539
52	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)	3.12906092
53	seminiferous tubule development (GO:0072520)	3.11266112
54	sympathetic nervous system development (GO:0048485)	3.11106549
55	alkaloid metabolic process (GO:0009820)	3.08106370
56	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.07609618
57	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.07609618
58	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.07609618
59	GDP-mannose metabolic process (GO:0019673)	3.07000950
60	GTP biosynthetic process (GO:0006183)	3.06362588
61	positive regulation of cAMP-mediated signaling (GO:0043950)	3.05612931
62	long-chain fatty acid biosynthetic process (GO:0042759)	3.05399351
63	detection of light stimulus involved in sensory perception (GO:0050962)	3.04753257
64	detection of light stimulus involved in visual perception (GO:0050908)	3.04753257
65	nucleobase catabolic process (GO:0046113)	3.04663866
66	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.04474735
67	histone H2A monoubiquitination (GO:0035518)	3.04026432
68	acrosome reaction (GO:0007340)	3.02574092
69	melanosome transport (GO:0032402)	3.02038563
70	response to folic acid (GO:0051593)	3.01673025
71	glyoxylate metabolic process (GO:0046487)	3.00586398
72	coenzyme A biosynthetic process (GO:0015937)	3.00163929
73	UTP biosynthetic process (GO:0006228)	2.99858771
74	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.98497834
75	DNA catabolic process, exonucleolytic (GO:0000738)	2.98151937
76	establishment of melanosome localization (GO:0032401)	2.94208191
77	post-embryonic morphogenesis (GO:0009886)	2.92488436
78	aldehyde catabolic process (GO:0046185)	2.89008304
79	T cell migration (GO:0072678)	2.88554063
80	cell wall macromolecule metabolic process (GO:0044036)	2.86305547
81	olfactory bulb development (GO:0021772)	2.86130904
82	pigment granule transport (GO:0051904)	2.85572968
83	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.84425904
84	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.83900299
85	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.83900299
86	gamma-aminobutyric acid transport (GO:0015812)	2.83589208
87	negative regulation of Ras GTPase activity (GO:0034261)	2.81544007
88	cellular biogenic amine biosynthetic process (GO:0042401)	2.80989693
89	lateral ventricle development (GO:0021670)	2.80900856
90	resolution of meiotic recombination intermediates (GO:0000712)	2.80481449
91	melanosome localization (GO:0032400)	2.80178380
92	L-methionine biosynthetic process (GO:0071265)	2.79822469
93	amino acid salvage (GO:0043102)	2.79822469
94	L-methionine salvage (GO:0071267)	2.79822469
95	regulation of cilium movement (GO:0003352)	2.79525422
96	cornea development in camera-type eye (GO:0061303)	2.79331855
97	establishment of pigment granule localization (GO:0051905)	2.78798942
98	amine biosynthetic process (GO:0009309)	2.77556582
99	regulation of T cell receptor signaling pathway (GO:0050856)	2.75223190
100	response to pheromone (GO:0019236)	2.74224538

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	6.04266740
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.63612708
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.17264683
4	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.96316037
5	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.72305876
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.67225686
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.66850331
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.59507645
9	P300_19829295_ChIP-Seq_ESCs_Human	2.51739330
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45761913
11	FUS_26573619_Chip-Seq_HEK293_Human	2.40262133
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.18675755
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18592444
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14093133
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.08552058
16	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.06905040
17	EWS_26573619_Chip-Seq_HEK293_Human	2.06401281
18	RNF2_27304074_Chip-Seq_NSC_Mouse	1.93879189
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.91373426
20	VDR_22108803_ChIP-Seq_LS180_Human	1.80218361
21	AR_21572438_ChIP-Seq_LNCaP_Human	1.71331630
22	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.70710854
23	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69365941
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.69365941
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.68590152
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.65226092
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.64080450
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.62618351
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.60503296
30	HTT_18923047_ChIP-ChIP_STHdh_Human	1.58906264
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58236182
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.56333121
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53344119
34	MYC_19829295_ChIP-Seq_ESCs_Human	1.53128276
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47830239
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.47632188
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45305771
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44199415
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43851898
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43662547
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.42642761
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.42103696
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42103696
44	NCOR_22424771_ChIP-Seq_293T_Human	1.41688574
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.40235008
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.39175161
47	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.37189490
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.36622552
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34816020
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.30606902
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.30215874
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28046477
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27893496
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27017861
55	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26611714
56	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26459718
57	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.25845945
58	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24309180
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.23201876
60	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21732822
61	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.21397229
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21048311
63	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.20106387
64	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19914640
65	BCAT_22108803_ChIP-Seq_LS180_Human	1.17712595
66	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17615280
67	TP53_22573176_ChIP-Seq_HFKS_Human	1.17009379
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.15934041
69	AR_25329375_ChIP-Seq_VCAP_Human	1.13781552
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.13725494
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12845680
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.12844569
73	VDR_23849224_ChIP-Seq_CD4+_Human	1.11795297
74	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.10490653
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.10080769
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09885844
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09885844
78	STAT3_23295773_ChIP-Seq_U87_Human	1.09700821
79	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08915465
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08253328
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07635428
82	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04382974
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.01685637
84	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00585107
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.99113837
86	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98838473
87	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98838473
88	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98109724
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97188679
90	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.96691005
91	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96502739
92	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95940094
93	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.95488695
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93275402
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92574097
96	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.91210171
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89322369
98	TBL1_22424771_ChIP-Seq_293T_Human	0.87466218
99	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.87453591
100	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.86220651

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.52292485
2	MP0001529_abnormal_vocalization	3.50666382
3	MP0000569_abnormal_digit_pigmentation	3.02892113
4	MP0003567_abnormal_fetal_cardiomyocyte	2.76230578
5	MP0002102_abnormal_ear_morphology	2.76153210
6	MP0002653_abnormal_ependyma_morphology	2.73679928
7	MP0005451_abnormal_body_composition	2.67941239
8	MP0008789_abnormal_olfactory_epithelium	2.52334350
9	MP0006072_abnormal_retinal_apoptosis	2.48405424
10	MP0005645_abnormal_hypothalamus_physiol	2.45050671
11	MP0003195_calcinosis	2.43210743
12	MP0003045_fibrosis	2.41458496
13	MP0009046_muscle_twitch	2.32793576
14	MP0005499_abnormal_olfactory_system	2.06987590
15	MP0005394_taste/olfaction_phenotype	2.06987590
16	MP0003329_amyloid_beta_deposits	1.94222813
17	MP0006276_abnormal_autonomic_nervous	1.87519893
18	MP0001485_abnormal_pinna_reflex	1.84124105
19	MP0003221_abnormal_cardiomyocyte_apopto	1.83044022
20	MP0004885_abnormal_endolymph	1.79100138
21	MP0009697_abnormal_copulation	1.78369209
22	MP0005360_urolithiasis	1.72701767
23	MP0000778_abnormal_nervous_system	1.72146484
24	MP0005171_absent_coat_pigmentation	1.69934278
25	MP0005671_abnormal_response_to	1.68019514
26	MP0001986_abnormal_taste_sensitivity	1.66090765
27	MP0002751_abnormal_autonomic_nervous	1.62196415
28	MP0005174_abnormal_tail_pigmentation	1.61504720
29	MP0005253_abnormal_eye_physiology	1.58636036
30	MP0000015_abnormal_ear_pigmentation	1.47878818
31	MP0002735_abnormal_chemical_nociception	1.46287028
32	MP0000604_amyloidosis	1.46068361
33	MP0002733_abnormal_thermal_nociception	1.45938410
34	MP0000049_abnormal_middle_ear	1.44387799
35	MP0001984_abnormal_olfaction	1.44174590
36	MP0003718_maternal_effect	1.43428012
37	MP0005551_abnormal_eye_electrophysiolog	1.42866470
38	MP0004147_increased_porphyrin_level	1.42381034
39	MP0004859_abnormal_synaptic_plasticity	1.39111435
40	MP0004510_myositis	1.34516935
41	MP0002822_catalepsy	1.32163020
42	MP0000372_irregular_coat_pigmentation	1.32158683
43	MP0003137_abnormal_impulse_conducting	1.32082763
44	MP0010368_abnormal_lymphatic_system	1.31623222
45	MP0000026_abnormal_inner_ear	1.31118347
46	MP0002138_abnormal_hepatobiliary_system	1.30069932
47	MP0008995_early_reproductive_senescence	1.28548670
48	MP0001970_abnormal_pain_threshold	1.28003198
49	MP0004270_analgesia	1.25526788
50	MP0008875_abnormal_xenobiotic_pharmacok	1.24858032
51	MP0000566_synostosis	1.23693167
52	MP0002234_abnormal_pharynx_morphology	1.23403617
53	MP0001486_abnormal_startle_reflex	1.23330464
54	MP0000462_abnormal_digestive_system	1.23230102
55	MP0002272_abnormal_nervous_system	1.22534665
56	MP0009745_abnormal_behavioral_response	1.21517311
57	MP0000631_abnormal_neuroendocrine_gland	1.20836335
58	MP0002557_abnormal_social/conspecific_i	1.18086396
59	MP0002572_abnormal_emotion/affect_behav	1.17746890
60	MP0005395_other_phenotype	1.15520732
61	MP0002233_abnormal_nose_morphology	1.15436722
62	MP0003879_abnormal_hair_cell	1.15355332
63	MP0001968_abnormal_touch/_nociception	1.10066833
64	MP0001963_abnormal_hearing_physiology	1.08355166
65	MP0001501_abnormal_sleep_pattern	1.08323527
66	MP0000955_abnormal_spinal_cord	1.05365443
67	MP0003136_yellow_coat_color	1.04861454
68	MP0002168_other_aberrant_phenotype	0.99880783
69	MP0002095_abnormal_skin_pigmentation	0.99721312
70	MP0002752_abnormal_somatic_nervous	0.98600017
71	MP0002229_neurodegeneration	0.98069822
72	MP0004134_abnormal_chest_morphology	0.95337327
73	MP0002734_abnormal_mechanical_nocicepti	0.94896150
74	MP0002882_abnormal_neuron_morphology	0.93824547
75	MP0002184_abnormal_innervation	0.92545404
76	MP0000371_diluted_coat_color	0.92152588
77	MP0002063_abnormal_learning/memory/cond	0.89708834
78	MP0003635_abnormal_synaptic_transmissio	0.86396335
79	MP0003698_abnormal_male_reproductive	0.84453773
80	MP0004484_altered_response_of	0.83313312
81	MP0004811_abnormal_neuron_physiology	0.82860054
82	MP0005386_behavior/neurological_phenoty	0.81322524
83	MP0004924_abnormal_behavior	0.81322524
84	MP0003693_abnormal_embryo_hatching	0.80725814
85	MP0005332_abnormal_amino_acid	0.78154520
86	MP0005075_abnormal_melanosome_morpholog	0.77991634
87	MP0002160_abnormal_reproductive_system	0.77686784
88	MP0001340_abnormal_eyelid_morphology	0.76590684
89	MP0004858_abnormal_nervous_system	0.76262032
90	MP0001905_abnormal_dopamine_level	0.75231905
91	MP0003385_abnormal_body_wall	0.74671770
92	MP0001929_abnormal_gametogenesis	0.74120678
93	MP0003632_abnormal_nervous_system	0.72962817
94	MP0002210_abnormal_sex_determination	0.72807307
95	MP0002067_abnormal_sensory_capabilities	0.72682233
96	MP0005195_abnormal_posterior_eye	0.72166904
97	MP0002064_seizures	0.72163259
98	MP0008877_abnormal_DNA_methylation	0.71695965
99	MP0000639_abnormal_adrenal_gland	0.69965709
100	MP0004145_abnormal_muscle_electrophysio	0.68992378

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.56544634
2	Molar tooth sign on MRI (HP:0002419)	4.56544634
3	Methylmalonic acidemia (HP:0002912)	4.55829056
4	True hermaphroditism (HP:0010459)	4.31478691
5	Sclerocornea (HP:0000647)	4.20870329
6	Bile duct proliferation (HP:0001408)	4.12935933
7	Abnormal biliary tract physiology (HP:0012439)	4.12935933
8	Abnormality of the renal collecting system (HP:0004742)	4.03888322
9	Reticulocytopenia (HP:0001896)	4.00685865
10	Congenital stationary night blindness (HP:0007642)	3.96492838
11	Bifid tongue (HP:0010297)	3.81990097
12	Duplicated collecting system (HP:0000081)	3.69528296
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.65007128
14	Pancreatic cysts (HP:0001737)	3.63177874
15	Pancreatic fibrosis (HP:0100732)	3.54391523
16	Limb dystonia (HP:0002451)	3.30364070
17	Failure to thrive in infancy (HP:0001531)	3.23626147
18	Aplastic anemia (HP:0001915)	3.17882836
19	Methylmalonic aciduria (HP:0012120)	3.17600002
20	Nephronophthisis (HP:0000090)	3.12651690
21	Abnormality of DNA repair (HP:0003254)	3.05321959
22	Tachypnea (HP:0002789)	3.01925479
23	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.82210043
24	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.80204026
25	Optic nerve coloboma (HP:0000588)	2.78851262
26	Abnormal respiratory epithelium morphology (HP:0012253)	2.75440666
27	Abnormal respiratory motile cilium morphology (HP:0005938)	2.75440666
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.73255050
29	Absent/shortened dynein arms (HP:0200106)	2.73255050
30	Male pseudohermaphroditism (HP:0000037)	2.71143136
31	Chromsome breakage (HP:0040012)	2.69966022
32	Cystic liver disease (HP:0006706)	2.62859376
33	Clubbing of toes (HP:0100760)	2.58129907
34	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.57002602
35	Postaxial foot polydactyly (HP:0001830)	2.55394359
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.50410854
37	Hypoplastic ischia (HP:0003175)	2.48921998
38	Nephrogenic diabetes insipidus (HP:0009806)	2.45692488
39	Preaxial hand polydactyly (HP:0001177)	2.40194709
40	Meckel diverticulum (HP:0002245)	2.38197959
41	Abnormality of the labia minora (HP:0012880)	2.37884879
42	Hyperglycinemia (HP:0002154)	2.37601824
43	Anencephaly (HP:0002323)	2.35648277
44	Abnormality of the ileum (HP:0001549)	2.34021177
45	Abnormality of pyrimidine metabolism (HP:0004353)	2.32932859
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.32393357
47	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.26792323
48	Abnormal ciliary motility (HP:0012262)	2.26183869
49	Esotropia (HP:0000565)	2.25395931
50	Asplenia (HP:0001746)	2.20081393
51	Epiphyseal dysplasia (HP:0002656)	2.18865931
52	Alacrima (HP:0000522)	2.16591868
53	Abnormality of the preputium (HP:0100587)	2.15577493
54	Abnormality of the ischium (HP:0003174)	2.15352108
55	Vacuolated lymphocytes (HP:0001922)	2.15055393
56	Furrowed tongue (HP:0000221)	2.13314242
57	Abnormality of the renal medulla (HP:0100957)	2.09537109
58	Postaxial hand polydactyly (HP:0001162)	2.08693260
59	Truncal obesity (HP:0001956)	2.08533631
60	Decreased lacrimation (HP:0000633)	2.08471373
61	Hypothermia (HP:0002045)	2.07608730
62	Febrile seizures (HP:0002373)	2.05951424
63	Abnormality of vitamin B metabolism (HP:0004340)	2.05668935
64	Medial flaring of the eyebrow (HP:0010747)	2.05044408
65	Narrow forehead (HP:0000341)	2.00197964
66	Absent thumb (HP:0009777)	1.99782236
67	Pancytopenia (HP:0001876)	1.96907643
68	Hypoplasia of the brainstem (HP:0002365)	1.95609520
69	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.95609520
70	Exercise-induced muscle cramps (HP:0003710)	1.93833007
71	Hemiparesis (HP:0001269)	1.93445678
72	Congenital primary aphakia (HP:0007707)	1.93361707
73	Lissencephaly (HP:0001339)	1.92445930
74	Gait imbalance (HP:0002141)	1.90513900
75	Abnormality of the parathyroid morphology (HP:0011766)	1.89040544
76	Impaired smooth pursuit (HP:0007772)	1.88969855
77	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.88099055
78	Sloping forehead (HP:0000340)	1.88029771
79	Homocystinuria (HP:0002156)	1.87561580
80	Abnormality of homocysteine metabolism (HP:0010919)	1.87561580
81	Horseshoe kidney (HP:0000085)	1.85721592
82	Oligohydramnios (HP:0001562)	1.84975899
83	Aganglionic megacolon (HP:0002251)	1.83540773
84	Severe global developmental delay (HP:0011344)	1.82979087
85	Triphalangeal thumb (HP:0001199)	1.82878573
86	Aplasia/Hypoplasia of the macula (HP:0008059)	1.81951305
87	Short tibia (HP:0005736)	1.80608071
88	Dicarboxylic aciduria (HP:0003215)	1.78944069
89	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.78944069
90	Ketosis (HP:0001946)	1.78875529
91	Abnormal auditory evoked potentials (HP:0006958)	1.78595219
92	Abnormality of chromosome stability (HP:0003220)	1.78133631
93	Abnormal rod and cone electroretinograms (HP:0008323)	1.78025565
94	Bone marrow hypocellularity (HP:0005528)	1.77845099
95	Abnormal pupillary function (HP:0007686)	1.77125101
96	Short clavicles (HP:0000894)	1.75640802
97	Aplasia/Hypoplasia of the lens (HP:0008063)	1.75334325
98	Ectopic kidney (HP:0000086)	1.75027184
99	Congenital hepatic fibrosis (HP:0002612)	1.74111813
100	Aplasia/Hypoplasia of the clavicles (HP:0006710)	1.73886765

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.77686245
2	GRK1	3.88681250
3	ADRBK2	3.79664192
4	TRIM28	3.68802550
5	MAP4K2	3.39388905
6	MAP3K4	3.35202694
7	EPHA4	2.62900111
8	BUB1	2.60112069
9	BCKDK	2.44515672
10	TAOK3	2.43543886
11	DDR2	2.05040076
12	BCR	1.89102642
13	MAP2K7	1.86971970
14	CSNK1A1L	1.82226396
15	WNK3	1.81859186
16	CSNK1G3	1.78060551
17	MAPK13	1.71214562
18	CLK1	1.69867607
19	NEK9	1.66944140
20	CSNK1G2	1.57784437
21	SRPK1	1.57756435
22	CDK19	1.56575681
23	CSNK1G1	1.52283928
24	PINK1	1.43890309
25	MARK1	1.39386061
26	AKT3	1.33022747
27	ERBB3	1.29454094
28	TBK1	1.26143622
29	IRAK1	1.24193162
30	DYRK1A	1.12297369
31	PRKD3	1.11848929
32	FRK	1.10473468
33	FGFR3	1.09795573
34	DYRK3	1.04526801
35	PTK2B	1.03458934
36	CASK	0.95656639
37	LMTK2	0.94188302
38	DYRK2	0.93382535
39	LIMK1	0.90057887
40	PBK	0.83860236
41	NTRK3	0.82551666
42	NTRK2	0.78292430
43	OXSR1	0.74536411
44	ADRBK1	0.69234029
45	RPS6KA4	0.68968782
46	DYRK1B	0.67948767
47	IRAK2	0.65724756
48	TESK2	0.63866252
49	MAP3K6	0.62232491
50	KDR	0.60570041
51	TXK	0.58365959
52	STK38L	0.57032183
53	ITK	0.56954658
54	PLK1	0.55001313
55	BMPR1B	0.53645013
56	CSNK1A1	0.52871977
57	UHMK1	0.49191631
58	MAPK7	0.48787942
59	PAK3	0.48614828
60	PLK4	0.47612090
61	CAMK2A	0.44808273
62	KSR2	0.44600466
63	CDK11A	0.42078823
64	NME1	0.41202230
65	PLK2	0.40450566
66	PRKACB	0.40314935
67	MUSK	0.39233710
68	FGFR2	0.39131325
69	GRK7	0.38975766
70	KSR1	0.38883994
71	PRKCE	0.38342863
72	STK39	0.38295861
73	TAOK1	0.37779217
74	PRKACA	0.37508671
75	PKN1	0.37157276
76	STK24	0.37126405
77	PRKCG	0.37105036
78	MINK1	0.35959758
79	PRKG1	0.35843321
80	INSRR	0.35282051
81	MAP2K4	0.34339629
82	MAP3K5	0.33601988
83	CDK3	0.33536934
84	CDK5	0.33024427
85	RAF1	0.32715225
86	CDK18	0.32327987
87	TNK2	0.32259442
88	PAK6	0.29367181
89	MAP3K1	0.29307596
90	VRK1	0.27920276
91	OBSCN	0.27776068
92	CDC7	0.27014408
93	CDK14	0.26726654
94	CDK15	0.26253658
95	PRKACG	0.25853998
96	PRKCB	0.25796369
97	PHKG2	0.24559977
98	PHKG1	0.24559977
99	LATS1	0.24401248
100	INSR	0.24223771

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.94547861
2	Linoleic acid metabolism_Homo sapiens_hsa00591	3.83893883
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.67512801
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.04374410
5	Steroid biosynthesis_Homo sapiens_hsa00100	2.60190128
6	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.41568212
7	Ether lipid metabolism_Homo sapiens_hsa00565	2.40186043
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.40171258
9	Nicotine addiction_Homo sapiens_hsa05033	2.30824940
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.24539773
11	Phototransduction_Homo sapiens_hsa04744	2.16369857
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.09027253
13	Butanoate metabolism_Homo sapiens_hsa00650	2.07705472
14	Propanoate metabolism_Homo sapiens_hsa00640	2.05816996
15	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.92168744
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.87438551
17	Serotonergic synapse_Homo sapiens_hsa04726	1.80719501
18	beta-Alanine metabolism_Homo sapiens_hsa00410	1.79400069
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.78169221
20	Histidine metabolism_Homo sapiens_hsa00340	1.76506604
21	Taste transduction_Homo sapiens_hsa04742	1.72303768
22	Peroxisome_Homo sapiens_hsa04146	1.69557866
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64288519
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.54326219
25	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.50061735
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.48876535
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.47390745
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.39212801
29	Caffeine metabolism_Homo sapiens_hsa00232	1.34989695
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32275093
31	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.29126756
32	Base excision repair_Homo sapiens_hsa03410	1.28229576
33	Olfactory transduction_Homo sapiens_hsa04740	1.23565291
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.23462919
35	Protein export_Homo sapiens_hsa03060	1.21663930
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.21229651
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.19879905
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17620648
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.15625381
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.13549441
41	Arginine and proline metabolism_Homo sapiens_hsa00330	1.10772928
42	Retinol metabolism_Homo sapiens_hsa00830	1.04180992
43	Primary immunodeficiency_Homo sapiens_hsa05340	0.97354576
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.94756954
45	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.94463335
46	Morphine addiction_Homo sapiens_hsa05032	0.93489045
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.93289060
48	Long-term depression_Homo sapiens_hsa04730	0.87370498
49	Parkinsons disease_Homo sapiens_hsa05012	0.85511714
50	Nitrogen metabolism_Homo sapiens_hsa00910	0.84521093
51	GABAergic synapse_Homo sapiens_hsa04727	0.83607487
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82010584
53	Fatty acid metabolism_Homo sapiens_hsa01212	0.81467602
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.79774046
55	Spliceosome_Homo sapiens_hsa03040	0.79651769
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.77113681
57	Basal transcription factors_Homo sapiens_hsa03022	0.76169988
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.74918696
59	Circadian entrainment_Homo sapiens_hsa04713	0.73747585
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.70149740
61	RNA degradation_Homo sapiens_hsa03018	0.68635071
62	Huntingtons disease_Homo sapiens_hsa05016	0.67451463
63	Bile secretion_Homo sapiens_hsa04976	0.63799332
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.61907745
65	Purine metabolism_Homo sapiens_hsa00230	0.61385600
66	Fatty acid degradation_Homo sapiens_hsa00071	0.60964350
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60836928
68	RNA polymerase_Homo sapiens_hsa03020	0.59150144
69	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.57969708
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56042040
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.55532507
72	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54611464
73	Arginine biosynthesis_Homo sapiens_hsa00220	0.54343831
74	ABC transporters_Homo sapiens_hsa02010	0.53545297
75	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.52195032
76	Fatty acid elongation_Homo sapiens_hsa00062	0.51708107
77	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.50660803
78	RNA transport_Homo sapiens_hsa03013	0.50611068
79	Metabolic pathways_Homo sapiens_hsa01100	0.48736109
80	Ribosome_Homo sapiens_hsa03010	0.46225143
81	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42374100
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41310936
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.38852158
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36820312
85	Alzheimers disease_Homo sapiens_hsa05010	0.36225238
86	Legionellosis_Homo sapiens_hsa05134	0.33482676
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33209657
88	Other glycan degradation_Homo sapiens_hsa00511	0.32578459
89	GnRH signaling pathway_Homo sapiens_hsa04912	0.31336993
90	Basal cell carcinoma_Homo sapiens_hsa05217	0.30983320
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30069203
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.29096875
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.28924163
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27692838
95	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26903062
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26424272
97	Renin-angiotensin system_Homo sapiens_hsa04614	0.24605363
98	Cocaine addiction_Homo sapiens_hsa05030	0.23947014
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.23816644
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.21434702

BAGE5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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