BAHCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.59552186
2negative regulation of erythrocyte differentiation (GO:0045647)5.78625554
3establishment of apical/basal cell polarity (GO:0035089)5.62032741
4transcription from mitochondrial promoter (GO:0006390)5.17791752
5replication fork processing (GO:0031297)5.01118778
6establishment of monopolar cell polarity (GO:0061162)4.95753275
7establishment or maintenance of monopolar cell polarity (GO:0061339)4.95753275
8embryonic process involved in female pregnancy (GO:0060136)4.89497151
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.85659415
10positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr4.77371134
11pre-miRNA processing (GO:0031054)4.69732363
12proline metabolic process (GO:0006560)4.61053150
13regulation of integrin activation (GO:0033623)4.39355816
14maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.28606309
15mitotic G1 DNA damage checkpoint (GO:0031571)4.27161791
16glucocorticoid receptor signaling pathway (GO:0042921)4.22607082
17negative regulation of mRNA processing (GO:0050686)4.20420598
18dosage compensation (GO:0007549)4.16573315
19DNA strand renaturation (GO:0000733)3.96616892
20positive regulation of protein homooligomerization (GO:0032464)3.93378280
21mannose metabolic process (GO:0006013)3.89923764
22convergent extension (GO:0060026)3.89743634
23oxidative demethylation (GO:0070989)3.89531417
24negative regulation of RNA splicing (GO:0033119)3.88168394
25definitive hemopoiesis (GO:0060216)3.87894811
26regulation of translational fidelity (GO:0006450)3.82103876
27mitochondrial DNA metabolic process (GO:0032042)3.81727626
28G1 DNA damage checkpoint (GO:0044783)3.77426443
29regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.77188421
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.77012408
31poly(A)+ mRNA export from nucleus (GO:0016973)3.74721444
32paraxial mesoderm development (GO:0048339)3.73131379
33histone H4-K12 acetylation (GO:0043983)3.70018091
34regulation of sister chromatid cohesion (GO:0007063)3.66324138
35embryonic camera-type eye development (GO:0031076)3.62462467
36negative regulation of cell cycle arrest (GO:0071157)3.62427626
37G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.58573908
38regulation of protein homooligomerization (GO:0032462)3.58293491
39anatomical structure regression (GO:0060033)3.56765153
40mitotic G1/S transition checkpoint (GO:0044819)3.56398443
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.55819425
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.55819425
43regulation of RNA export from nucleus (GO:0046831)3.53706346
44regulation of NFAT protein import into nucleus (GO:0051532)3.53183923
45embryonic placenta development (GO:0001892)3.51338112
46mRNA cleavage (GO:0006379)3.50595637
47cranial nerve morphogenesis (GO:0021602)3.48386418
48neural tube development (GO:0021915)3.48034330
49positive regulation of synapse maturation (GO:0090129)3.47897726
50regulation of gene silencing by RNA (GO:0060966)3.47851947
51regulation of posttranscriptional gene silencing (GO:0060147)3.47851947
52regulation of gene silencing by miRNA (GO:0060964)3.47851947
53heterochromatin organization (GO:0070828)3.46922247
54negative regulation of mRNA metabolic process (GO:1903312)3.46408111
55regulation of DNA damage checkpoint (GO:2000001)3.46160666
56histone H3-K4 trimethylation (GO:0080182)3.43725314
57DNA topological change (GO:0006265)3.40846351
58negative regulation of cell size (GO:0045792)3.38600071
59positive regulation by host of viral transcription (GO:0043923)3.36072887
60negative regulation of JAK-STAT cascade (GO:0046426)3.35174557
61intracellular estrogen receptor signaling pathway (GO:0030520)3.34233348
62negative regulation of myotube differentiation (GO:0010832)3.28331241
63viral mRNA export from host cell nucleus (GO:0046784)3.28202132
64corticosteroid receptor signaling pathway (GO:0031958)3.27982557
65DNA deamination (GO:0045006)3.27105410
66polarized epithelial cell differentiation (GO:0030859)3.25847016
67base-excision repair (GO:0006284)3.24813419
68DNA integration (GO:0015074)3.22930957
69regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.21096425
70face development (GO:0060324)3.21019785
71negative regulation of chondrocyte differentiation (GO:0032331)3.20220721
72regulation of hippo signaling (GO:0035330)3.19320635
73regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.16645463
74nodal signaling pathway (GO:0038092)3.13924929
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13775845
76histone H3-K4 methylation (GO:0051568)3.10600030
77termination of RNA polymerase II transcription (GO:0006369)3.09504797
78head development (GO:0060322)3.08697876
79collecting duct development (GO:0072044)3.08454001
80cell migration in hindbrain (GO:0021535)3.08301783
81semaphorin-plexin signaling pathway (GO:0071526)3.06182209
82proximal/distal pattern formation (GO:0009954)3.05355932
83apoptotic process involved in morphogenesis (GO:0060561)3.02462532
84protein retention in ER lumen (GO:0006621)3.01004207
85negative regulation of gene expression, epigenetic (GO:0045814)2.99655260
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.98783610
87lateral sprouting from an epithelium (GO:0060601)2.98382954
88cerebellar granule cell differentiation (GO:0021707)2.98239253
89peptidyl-arginine omega-N-methylation (GO:0035247)2.97531704
90neural tube closure (GO:0001843)2.95570753
91histone H3-K9 methylation (GO:0051567)2.95523482
92histone lysine methylation (GO:0034968)2.93329852
93trophectodermal cell differentiation (GO:0001829)2.93209965
94histone H3-K9 modification (GO:0061647)2.91526604
95regulation of double-strand break repair (GO:2000779)2.90697500
96tube closure (GO:0060606)2.90344206
97regulation of synapse maturation (GO:0090128)2.89572695
98negative regulation of Ras GTPase activity (GO:0034261)2.89092015
99hippo signaling (GO:0035329)2.88994917
100regulation of stem cell maintenance (GO:2000036)2.86390238
101positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.85301259
102positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.85301259
103positive regulation of mitotic sister chromatid separation (GO:1901970)2.85301259
104synaptic vesicle docking involved in exocytosis (GO:0016081)2.85156818
105cell-cell junction maintenance (GO:0045217)2.84555654
106embryonic eye morphogenesis (GO:0048048)2.83261314
107regulation of glucose import in response to insulin stimulus (GO:2001273)2.83098122
108stress granule assembly (GO:0034063)2.82688948
109regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82688607
110negative regulation of cartilage development (GO:0061037)2.82223033
111peptidyl-lysine dimethylation (GO:0018027)2.80900286
112positive regulation of CREB transcription factor activity (GO:0032793)2.79631124
113glial cell migration (GO:0008347)2.79379941
114atrioventricular valve morphogenesis (GO:0003181)2.76995187
115kinetochore assembly (GO:0051382)2.76435219
116positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.75794918
117response to muramyl dipeptide (GO:0032495)2.75752994
118meiotic chromosome segregation (GO:0045132)2.75708449
119spinal cord development (GO:0021510)2.74665675
120telomere maintenance via semi-conservative replication (GO:0032201)2.73783980
121histone arginine methylation (GO:0034969)2.72969859
122embryonic camera-type eye morphogenesis (GO:0048596)2.72132041
123regulation of response to osmotic stress (GO:0047484)2.71906890
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.71307574
125dopamine receptor signaling pathway (GO:0007212)2.70799863
126DNA unwinding involved in DNA replication (GO:0006268)2.69253648
127regulation of ARF GTPase activity (GO:0032312)2.69196936
128histone H4 deacetylation (GO:0070933)2.69186995
129negative regulation of glial cell proliferation (GO:0060253)2.68919192
130coronary vasculature morphogenesis (GO:0060977)2.68130789
131mitotic sister chromatid segregation (GO:0000070)2.66762576
132peptidyl-arginine N-methylation (GO:0035246)2.65852535
133peptidyl-arginine methylation (GO:0018216)2.65852535
134nucleosome disassembly (GO:0006337)2.65771398
135protein-DNA complex disassembly (GO:0032986)2.65771398
136regulation of female gonad development (GO:2000194)2.63994879
137histone H4-K8 acetylation (GO:0043982)2.63970724
138histone H4-K5 acetylation (GO:0043981)2.63970724
139negative regulation of granulocyte differentiation (GO:0030853)2.62765224
140regulation of nucleobase-containing compound transport (GO:0032239)2.62605297
141anterior/posterior axis specification, embryo (GO:0008595)2.62218978
142negative regulation of fatty acid transport (GO:2000192)2.61565814
143positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.61306166
144histone H3 deacetylation (GO:0070932)2.61138825
145DNA double-strand break processing (GO:0000729)2.60928950
146sister chromatid segregation (GO:0000819)2.60458910
147chromatin silencing (GO:0006342)2.60312203
148formation of translation preinitiation complex (GO:0001731)2.59304450
149peripheral nervous system neuron development (GO:0048935)2.57809207
150insulin-like growth factor receptor signaling pathway (GO:0048009)2.57269298
151neuromuscular process controlling balance (GO:0050885)2.56170572
152osteoblast development (GO:0002076)2.55274223
153adherens junction assembly (GO:0034333)2.55160651
154cytoskeletal anchoring at plasma membrane (GO:0007016)2.54775637
1553-UTR-mediated mRNA stabilization (GO:0070935)2.54218802
156heart valve formation (GO:0003188)2.53628325
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.51974604
158regulation of ARF protein signal transduction (GO:0032012)2.51843863
159layer formation in cerebral cortex (GO:0021819)2.51663489
160histone methylation (GO:0016571)2.50115831
161locomotory exploration behavior (GO:0035641)2.49500905
162somatic stem cell division (GO:0048103)2.49147675
163camera-type eye morphogenesis (GO:0048593)2.48799165
164positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.48319455
165negative regulation of striated muscle cell differentiation (GO:0051154)2.48298357
166phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.46723714
167cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46249076
168histone lysine demethylation (GO:0070076)2.45320718
169white fat cell differentiation (GO:0050872)2.42898009
170embryonic retina morphogenesis in camera-type eye (GO:0060059)2.41282199
171protein targeting to plasma membrane (GO:0072661)2.41187913
172Peyers patch development (GO:0048541)2.40673293
173mucosal-associated lymphoid tissue development (GO:0048537)2.40673293
174negative regulation of histone methylation (GO:0031061)2.38922654
175eye morphogenesis (GO:0048592)2.38654251
176regulation of fatty acid beta-oxidation (GO:0031998)2.38246476
177regulation of histone H3-K4 methylation (GO:0051569)2.37216228
178thyroid gland development (GO:0030878)2.37185715
179positive regulation of gene expression, epigenetic (GO:0045815)2.35107035
180lymph vessel development (GO:0001945)2.34936679
181UV protection (GO:0009650)2.34635187
182histone deubiquitination (GO:0016578)2.32031615
183histone demethylation (GO:0016577)2.31744854
184cytoplasmic sequestering of transcription factor (GO:0042994)2.31691397

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.80194608
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.70028560
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.30444329
4SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.04307532
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.02116011
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.02116011
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.02116011
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.95341567
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.55223070
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.44753432
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40657897
12* VDR_24763502_ChIP-Seq_THP-1_Human2.39698473
13MYC_22102868_ChIP-Seq_BL_Human2.39366169
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.32335742
15DROSHA_22980978_ChIP-Seq_HELA_Human2.30288750
16* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.28967380
17* VDR_21846776_ChIP-Seq_THP-1_Human2.27546454
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.25198685
19EZH2_22144423_ChIP-Seq_EOC_Human2.19051938
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.11024325
21POU5F1_16518401_ChIP-PET_MESCs_Mouse2.04848306
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02409887
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96487273
24* LXR_22292898_ChIP-Seq_THP-1_Human1.96142237
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93123631
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91130871
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.91000666
28* KDM2B_26808549_Chip-Seq_DND41_Human1.89954453
29* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88913909
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88698784
31SCL_19346495_ChIP-Seq_HPC-7_Human1.87818033
32NANOG_21062744_ChIP-ChIP_HESCs_Human1.87546495
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.85360840
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.85132770
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83445104
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77316945
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.77168007
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77099359
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.77056494
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75439120
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.75346267
42P68_20966046_ChIP-Seq_HELA_Human1.74007949
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73957789
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69010908
45* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68825084
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66527956
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64739238
48* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.64102533
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62765521
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62560901
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60242513
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.60091762
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59894655
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58925860
55* KDM2B_26808549_Chip-Seq_K562_Human1.55635841
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.54967794
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54480207
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54480207
59* TCF7_22412390_ChIP-Seq_EML_Mouse1.53671695
60* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.53329496
61ZNF263_19887448_ChIP-Seq_K562_Human1.53257838
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.52955174
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.51257353
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.51016511
65* RARB_27405468_Chip-Seq_BRAIN_Mouse1.49903763
66* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48869892
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48701753
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.48573812
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47118850
70* ELK3_25401928_ChIP-Seq_HUVEC_Human1.46876874
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46195506
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45768517
73RACK7_27058665_Chip-Seq_MCF-7_Human1.45746282
74* RNF2_27304074_Chip-Seq_ESCs_Mouse1.45088102
75SMC4_20622854_ChIP-Seq_HELA_Human1.44913229
76* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44641154
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44599071
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42366676
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37842030
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37692347
81* UTX_26944678_Chip-Seq_JUKART_Human1.37245794
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.36815331
83CTCF_27219007_Chip-Seq_Bcells_Human1.36544996
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36339138
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.36024013
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35239938
87* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33192979
88* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31523045
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.30825741
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30423483
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29969174
92* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29903476
93* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28930185
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25443385
95* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24545683
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23499525
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.23372064
98MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22869317
99SOX2_18692474_ChIP-Seq_MESCs_Mouse1.22236113
100* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22175819
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21823503
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.21697063
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20948275
104PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20526897
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19793959
106ELF1_20517297_ChIP-Seq_JURKAT_Human1.19445457
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19328080
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.18603451
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.18198839
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17804294
111* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15814289
112* GATA1_19941827_ChIP-Seq_MEL_Mouse1.15741982
113* CREB1_26743006_Chip-Seq_LNCaP_Human1.15686973
114* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14880417
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13859036
116NCOR1_26117541_ChIP-Seq_K562_Human1.13449604
117TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12446530
118TET1_21451524_ChIP-Seq_MESCs_Mouse1.12129776
119MAF_26560356_Chip-Seq_TH2_Human1.12122524
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11762298
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11549319
122* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10662451
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10577079
124MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10149848
125* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09401895
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08791096
127POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08704966
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08235676
129NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07626483
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07601679
131PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06984990
132MAF_26560356_Chip-Seq_TH1_Human1.06467240
133* RING1B_27294783_Chip-Seq_ESCs_Mouse1.05115238
134* RUNX1_27514584_Chip-Seq_MCF-7_Human1.05100131
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04893228
136* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04831160
137TP53_22127205_ChIP-Seq_IMR90_Human1.04723025
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04629135
139* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04359317
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03890261
141* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03271515
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03226646
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02477392
144ESR2_21235772_ChIP-Seq_MCF-7_Human1.02291475
145E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01773145
146SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00658443
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99551940
148NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99033130
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98947489
150EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98527635
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.98219669
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97940315
153RUNX1_22412390_ChIP-Seq_EML_Mouse0.97896577
154* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97711643
155OCT4_19829295_ChIP-Seq_ESCs_Human0.97399128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.36072671
2MP0008057_abnormal_DNA_replication3.81039575
3MP0005409_darkened_coat_color3.74799697
4MP0009278_abnormal_bone_marrow3.65970566
5MP0004859_abnormal_synaptic_plasticity3.05831780
6MP0002396_abnormal_hematopoietic_system2.93418253
7MP0004233_abnormal_muscle_weight2.78664097
8MP0003283_abnormal_digestive_organ2.62878042
9MP0005076_abnormal_cell_differentiation2.59678196
10MP0003890_abnormal_embryonic-extraembry2.59051950
11MP0003172_abnormal_lysosome_physiology2.53024383
12MP0008995_early_reproductive_senescence2.41402725
13MP0005171_absent_coat_pigmentation2.34275815
14MP0002653_abnormal_ependyma_morphology2.33824088
15MP0002249_abnormal_larynx_morphology2.30959163
16MP0003119_abnormal_digestive_system2.20360844
17MP0004808_abnormal_hematopoietic_stem2.19042031
18MP0004185_abnormal_adipocyte_glucose2.16410223
19MP0010094_abnormal_chromosome_stability2.02683211
20MP0008877_abnormal_DNA_methylation1.93586452
21MP0002084_abnormal_developmental_patter1.93467196
22MP0003705_abnormal_hypodermis_morpholog1.92951276
23MP0001293_anophthalmia1.92700170
24MP0003111_abnormal_nucleus_morphology1.90997206
25MP0000681_abnormal_thyroid_gland1.88624220
26MP0004197_abnormal_fetal_growth/weight/1.88110560
27MP0004133_heterotaxia1.82977942
28MP0004858_abnormal_nervous_system1.82011021
29MP0003567_abnormal_fetal_cardiomyocyte1.79183553
30MP0002085_abnormal_embryonic_tissue1.75999072
31MP0002282_abnormal_trachea_morphology1.74305130
32MP0010352_gastrointestinal_tract_polyps1.74096836
33MP0003279_aneurysm1.73375985
34MP0005058_abnormal_lysosome_morphology1.71561613
35MP0005666_abnormal_adipose_tissue1.69974041
36MP0009053_abnormal_anal_canal1.69453259
37MP0002822_catalepsy1.67825017
38MP0002932_abnormal_joint_morphology1.63143701
39MP0003385_abnormal_body_wall1.61645722
40MP0002877_abnormal_melanocyte_morpholog1.61596292
41MP0002086_abnormal_extraembryonic_tissu1.57557227
42MP0005397_hematopoietic_system_phenotyp1.55983465
43MP0001545_abnormal_hematopoietic_system1.55983465
44MP0001697_abnormal_embryo_size1.55577697
45MP0003935_abnormal_craniofacial_develop1.53934680
46MP0001672_abnormal_embryogenesis/_devel1.50489783
47MP0005380_embryogenesis_phenotype1.50489783
48MP0005623_abnormal_meninges_morphology1.50136738
49MP0003122_maternal_imprinting1.47514262
50MP0004957_abnormal_blastocyst_morpholog1.46111607
51MP0003942_abnormal_urinary_system1.44998303
52MP0000537_abnormal_urethra_morphology1.44565914
53MP0001188_hyperpigmentation1.42705439
54MP0000049_abnormal_middle_ear1.41078495
55MP0003635_abnormal_synaptic_transmissio1.39174688
56MP0005670_abnormal_white_adipose1.36324245
57MP0004381_abnormal_hair_follicle1.35679813
58MP0003755_abnormal_palate_morphology1.35258658
59MP0003077_abnormal_cell_cycle1.35131376
60MP0002697_abnormal_eye_size1.34188090
61MP0002111_abnormal_tail_morphology1.33865360
62MP0003786_premature_aging1.32458336
63MP0002116_abnormal_craniofacial_bone1.32263515
64MP0005423_abnormal_somatic_nervous1.30982683
65MP0009672_abnormal_birth_weight1.30651497
66MP0000350_abnormal_cell_proliferation1.30338380
67MP0003984_embryonic_growth_retardation1.29217305
68MP0003115_abnormal_respiratory_system1.28669296
69MP0005174_abnormal_tail_pigmentation1.28552281
70MP0001348_abnormal_lacrimal_gland1.28290266
71MP0002009_preneoplasia1.27971505
72MP0002088_abnormal_embryonic_growth/wei1.26407926
73MP0001730_embryonic_growth_arrest1.24082786
74MP0002063_abnormal_learning/memory/cond1.21636001
75MP0003121_genomic_imprinting1.20946422
76MP0005220_abnormal_exocrine_pancreas1.20621462
77MP0003861_abnormal_nervous_system1.19184391
78MP0000462_abnormal_digestive_system1.18838589
79MP0008932_abnormal_embryonic_tissue1.18239957
80MP0005367_renal/urinary_system_phenotyp1.17109448
81MP0000516_abnormal_urinary_system1.17109448
82MP0002114_abnormal_axial_skeleton1.15811631
83MP0005375_adipose_tissue_phenotype1.15675132
84MP0000432_abnormal_head_morphology1.15238375
85MP0004130_abnormal_muscle_cell1.11869299
86MP0000428_abnormal_craniofacial_morphol1.10283637
87MP0000534_abnormal_ureter_morphology1.10170806
88MP0002092_abnormal_eye_morphology1.08486019
89MP0008438_abnormal_cutaneous_collagen1.08356967
90MP0002938_white_spotting1.08292657
91MP0002080_prenatal_lethality1.08185894
92MP0008058_abnormal_DNA_repair1.07501195
93MP0003123_paternal_imprinting1.05726861
94MP0003329_amyloid_beta_deposits1.05026176
95MP0001340_abnormal_eyelid_morphology1.02089083
96MP0003948_abnormal_gas_homeostasis1.01628387
97MP0000733_abnormal_muscle_development1.01275518
98MP0005248_abnormal_Harderian_gland1.00933250
99MP0001502_abnormal_circadian_rhythm1.00803234
100MP0003091_abnormal_cell_migration0.97896840
101MP0002925_abnormal_cardiovascular_devel0.97491613
102MP0000566_synostosis0.96380998
103MP0009703_decreased_birth_body0.95856621
104MP0008569_lethality_at_weaning0.95271262
105MP0006138_congestive_heart_failure0.94935604
106MP0005508_abnormal_skeleton_morphology0.94779166
107MP0000759_abnormal_skeletal_muscle0.94558006
108MP0006072_abnormal_retinal_apoptosis0.94051454
109MP0002089_abnormal_postnatal_growth/wei0.93651595
110MP0001486_abnormal_startle_reflex0.92316906
111MP0010630_abnormal_cardiac_muscle0.91582602
112MP0000762_abnormal_tongue_morphology0.91165425
113MP0003634_abnormal_glial_cell0.91155275
114MP0008961_abnormal_basal_metabolism0.90924208
115MP0000955_abnormal_spinal_cord0.90096281
116MP0000015_abnormal_ear_pigmentation0.89846559
117MP0002733_abnormal_thermal_nociception0.89844825
118MP0002152_abnormal_brain_morphology0.89785878
119MP0000678_abnormal_parathyroid_gland0.89148220
120MP0000003_abnormal_adipose_tissue0.88758639
121MP0000579_abnormal_nail_morphology0.88342542
122MP0000467_abnormal_esophagus_morphology0.86909653
123MP0000778_abnormal_nervous_system0.86538949
124MP0000371_diluted_coat_color0.85652873
125MP0005503_abnormal_tendon_morphology0.85525617
126MP0000490_abnormal_crypts_of0.84931823
127MP0001943_abnormal_respiration0.84324990
128MP0002269_muscular_atrophy0.83453784
129MP0000747_muscle_weakness0.82597409
130MP0003937_abnormal_limbs/digits/tail_de0.82195922
131MP0001879_abnormal_lymphatic_vessel0.80656924
132MP0001849_ear_inflammation0.80495145
133MP0001286_abnormal_eye_development0.79657020
134MP0002751_abnormal_autonomic_nervous0.79526805
135MP0004811_abnormal_neuron_physiology0.79513082
136MP0003137_abnormal_impulse_conducting0.79403869
137MP0003045_fibrosis0.79003996
138MP0001270_distended_abdomen0.78840515
139MP0010307_abnormal_tumor_latency0.78442389
140MP0005257_abnormal_intraocular_pressure0.78178796
141MP0002970_abnormal_white_adipose0.77705912
142MP0002064_seizures0.76502013
143MP0009379_abnormal_foot_pigmentation0.76263314
144MP0004134_abnormal_chest_morphology0.76200667
145MP0002075_abnormal_coat/hair_pigmentati0.76102684
146MP0004782_abnormal_surfactant_physiolog0.75814150
147* MP0002081_perinatal_lethality0.75538712
148MP0002735_abnormal_chemical_nociception0.75179728
149MP0000266_abnormal_heart_morphology0.74356456
150MP0002108_abnormal_muscle_morphology0.73761096
151MP0001784_abnormal_fluid_regulation0.73683416
152MP0009250_abnormal_appendicular_skeleto0.73249937
153MP0003941_abnormal_skin_development0.73099638
154MP0002184_abnormal_innervation0.72466081
155MP0003828_pulmonary_edema0.71756132
156MP0001915_intracranial_hemorrhage0.71701792
157MP0010770_preweaning_lethality0.71101570
158MP0002082_postnatal_lethality0.71101570
159MP0005621_abnormal_cell_physiology0.70432994
160MP0002572_abnormal_emotion/affect_behav0.69617992
161MP0004087_abnormal_muscle_fiber0.68855843
162MP0010769_abnormal_survival0.68586727
163MP0000751_myopathy0.67424001

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.33291766
2Obstructive sleep apnea (HP:0002870)4.25309306
3Abnormality of the fingertips (HP:0001211)3.86901897
4Turricephaly (HP:0000262)3.77852139
5Annular pancreas (HP:0001734)3.77504543
6Facial hemangioma (HP:0000329)3.64333910
7Coronal craniosynostosis (HP:0004440)3.54608882
8Ulnar bowing (HP:0003031)3.29651411
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.22994629
10Short 4th metacarpal (HP:0010044)3.22994629
11Rectovaginal fistula (HP:0000143)3.09319323
12Rectal fistula (HP:0100590)3.09319323
13Broad face (HP:0000283)3.08867820
14Intestinal fistula (HP:0100819)3.05298354
15Concave nail (HP:0001598)3.03717388
16Renal duplication (HP:0000075)3.03349995
17Selective tooth agenesis (HP:0001592)2.97193188
18Astrocytoma (HP:0009592)2.92700207
19Abnormality of the astrocytes (HP:0100707)2.92700207
20Abnormality of the aortic arch (HP:0012303)2.92114965
21Cerebral aneurysm (HP:0004944)2.88845546
22Genetic anticipation (HP:0003743)2.84121085
23Hyperacusis (HP:0010780)2.80600188
24Alopecia of scalp (HP:0002293)2.77389005
25Vaginal fistula (HP:0004320)2.74531455
26Volvulus (HP:0002580)2.73410080
27Pointed chin (HP:0000307)2.71191736
28Acute myeloid leukemia (HP:0004808)2.69070022
29Anteriorly placed anus (HP:0001545)2.64972693
30Intestinal atresia (HP:0011100)2.64243301
31Short humerus (HP:0005792)2.62658700
32Abnormal number of incisors (HP:0011064)2.58432283
33Congenital hip dislocation (HP:0001374)2.57155010
34Abnormality of the 4th metacarpal (HP:0010012)2.53796605
35Neoplasm of the oral cavity (HP:0100649)2.51847329
36Hamartoma (HP:0010566)2.44591128
37Short 5th finger (HP:0009237)2.43644212
38Aplasia/hypoplasia of the humerus (HP:0006507)2.43180849
39Abnormality of the thoracic spine (HP:0100711)2.41036625
40Abnormality of the columella (HP:0009929)2.38959744
41Thoracic kyphosis (HP:0002942)2.38505473
42Vertebral fusion (HP:0002948)2.35214566
43Poikiloderma (HP:0001029)2.34352616
44Dysmetric saccades (HP:0000641)2.34128870
45Hypochromic microcytic anemia (HP:0004840)2.33947626
46Disproportionate tall stature (HP:0001519)2.33879611
47Insomnia (HP:0100785)2.32695264
48Ependymoma (HP:0002888)2.32571621
49Renovascular hypertension (HP:0100817)2.30313723
50Broad thumb (HP:0011304)2.29508246
51Hypoplasia of the iris (HP:0007676)2.28862227
52Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.26555799
53Macroorchidism (HP:0000053)2.26505728
54Broad alveolar ridges (HP:0000187)2.24373966
55Orthostatic hypotension (HP:0001278)2.24241353
56Abnormality of the labia minora (HP:0012880)2.23812717
57Patellar aplasia (HP:0006443)2.23198392
58Glioma (HP:0009733)2.22944054
59Abnormality of the lower motor neuron (HP:0002366)2.22803309
60Hypoplastic ischia (HP:0003175)2.22790173
61Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.22698159
62Vertebral hypoplasia (HP:0008417)2.22698159
63Choanal stenosis (HP:0000452)2.20796242
64Acute lymphatic leukemia (HP:0006721)2.17432601
65Male infertility (HP:0003251)2.16350398
66Shallow orbits (HP:0000586)2.15900861
67Elfin facies (HP:0004428)2.13923557
68Alacrima (HP:0000522)2.13762039
69Tongue fasciculations (HP:0001308)2.12325820
70Dislocated radial head (HP:0003083)2.11861727
71Muscle fibrillation (HP:0010546)2.10426787
72Narrow palate (HP:0000189)2.09315450
73Absent radius (HP:0003974)2.09148574
74Increased number of teeth (HP:0011069)2.08487822
75Broad distal phalanx of finger (HP:0009836)2.08411112
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07821314
77Abnormality of binocular vision (HP:0011514)2.07390730
78Diplopia (HP:0000651)2.07390730
79Patellar dislocation (HP:0002999)2.06975505
80Precocious puberty (HP:0000826)2.06627382
81Bell-shaped thorax (HP:0001591)2.06537041
82Germ cell neoplasia (HP:0100728)2.05763167
83Protrusio acetabuli (HP:0003179)2.05632348
84Increased nuchal translucency (HP:0010880)2.04827645
85Aplasia/Hypoplasia of the patella (HP:0006498)2.04696047
86Bowing of the arm (HP:0006488)2.03720538
87Bowed forearm bones (HP:0003956)2.03720538
88Hypotelorism (HP:0000601)2.03343677
89Abnormality of the ischium (HP:0003174)2.03194817
90Abnormality of the radial head (HP:0003995)2.03109825
91Heterotopia (HP:0002282)2.03079046
92Obsessive-compulsive behavior (HP:0000722)2.02116947
93Shawl scrotum (HP:0000049)2.02093194
94Spina bifida occulta (HP:0003298)2.01771648
95Narrow nasal bridge (HP:0000446)2.01606943
96Stereotypic behavior (HP:0000733)2.00847821
97Overriding aorta (HP:0002623)2.00078474
98Hemivertebrae (HP:0002937)1.99834570
99Supernumerary ribs (HP:0005815)1.99136119
100Aplasia involving forearm bones (HP:0009822)1.99065367
101Absent forearm bone (HP:0003953)1.99065367
102Basal cell carcinoma (HP:0002671)1.98247682
103Abnormality of the diencephalon (HP:0010662)1.98136202
104Medulloblastoma (HP:0002885)1.97619584
105Metaphyseal cupping (HP:0003021)1.96667002
106Impaired smooth pursuit (HP:0007772)1.95511106
107Abnormal hemoglobin (HP:0011902)1.95234288
108Genu recurvatum (HP:0002816)1.94807828
109Broad toe (HP:0001837)1.93919487
110Long palpebral fissure (HP:0000637)1.93189202
111Short phalanx of the thumb (HP:0009660)1.91391804
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.90677033
113Thin bony cortex (HP:0002753)1.90035384
114Visual hallucinations (HP:0002367)1.89884245
115Thin ribs (HP:0000883)1.89636704
116Vertebral arch anomaly (HP:0008438)1.89624391
117Squamous cell carcinoma (HP:0002860)1.87788043
118Truncal obesity (HP:0001956)1.87757142
119Syringomyelia (HP:0003396)1.87729714
120Spinal cord lesions (HP:0100561)1.87729714
121Spondylolisthesis (HP:0003302)1.86246060
122Flat cornea (HP:0007720)1.86030104
123Chin dimple (HP:0010751)1.85717400
124Flat acetabular roof (HP:0003180)1.85232426
125Broad hallux (HP:0010055)1.84355046
126High anterior hairline (HP:0009890)1.84294038
127Bowel incontinence (HP:0002607)1.84272945
128Lymphangioma (HP:0100764)1.84105271
129Split hand (HP:0001171)1.82713902
130Asymmetry of the thorax (HP:0001555)1.82522152
131Anophthalmia (HP:0000528)1.82445877
132Broad phalanges of the hand (HP:0009768)1.81932271
133Neoplasm of striated muscle (HP:0009728)1.81665168
134Bowel diverticulosis (HP:0005222)1.79961157
135Lower limb asymmetry (HP:0100559)1.79845626
136Atelectasis (HP:0100750)1.79791929
137Trigonocephaly (HP:0000243)1.79649341
138Mitral regurgitation (HP:0001653)1.79197111
139Deep palmar crease (HP:0006191)1.78968071
140Gastrointestinal atresia (HP:0002589)1.78296996
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77700895
142Bladder diverticulum (HP:0000015)1.77603024
143Short chin (HP:0000331)1.76543279
144Urethral obstruction (HP:0000796)1.75436769
145Pseudobulbar signs (HP:0002200)1.75370792
146Tented upper lip vermilion (HP:0010804)1.75332612
147Premature skin wrinkling (HP:0100678)1.75159067
148Midline defect of the nose (HP:0004122)1.75007136
149Broad forehead (HP:0000337)1.74963865
150Neoplasm of the heart (HP:0100544)1.74675566
151Long eyelashes (HP:0000527)1.74203304
152Truncus arteriosus (HP:0001660)1.71913415
153Abnormality of the parietal bone (HP:0002696)1.71217694
154Relative macrocephaly (HP:0004482)1.70798629
155Abnormal large intestine physiology (HP:0012700)1.68358430
156Truncal ataxia (HP:0002078)1.66721247
157Tracheomalacia (HP:0002779)1.66606193
158Megalocornea (HP:0000485)1.66570494
159Cupped ribs (HP:0000887)1.65743050
160Spinal canal stenosis (HP:0003416)1.65037318
161Laryngomalacia (HP:0001601)1.64283317
162Broad finger (HP:0001500)1.62015564
163Thick eyebrow (HP:0000574)1.62007752
164Self-mutilation (HP:0000742)1.60780095
165Flared metaphyses (HP:0003015)1.60196020
166Cutis marmorata (HP:0000965)1.59709935
167Deeply set eye (HP:0000490)1.59127170
168Attention deficit hyperactivity disorder (HP:0007018)1.58153244
169Polygenic inheritance (HP:0010982)1.58068015
170Abnormality of the pubic bones (HP:0003172)1.57736168
171Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57259073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.71125194
2DDR24.12994456
3MAPK153.25769495
4MAP3K63.15457161
5PRPF4B3.07194608
6TYRO32.88353565
7CDK122.86701510
8PDGFRA2.66050780
9MAP3K102.58525341
10UHMK12.29444700
11MATK2.21909887
12SMG12.21055501
13INSRR2.11822453
14MAP3K112.11722826
15BMX2.02338464
16LATS22.01453523
17CDK71.82857005
18KIT1.79501224
19TRIB31.75017029
20DYRK1B1.70274199
21FGR1.66683222
22DAPK11.66580512
23FLT31.65655719
24PRKD21.60614390
25CDK61.60151096
26EEF2K1.52295535
27CAMKK11.44961001
28MTOR1.41211345
29LATS11.40280676
30EPHB21.36654298
31CDC71.34854504
32PINK11.34337208
33YES11.34015400
34MAP2K31.33717165
35RIPK11.33077160
36FES1.32166878
37NEK21.31480134
38BRD41.22479987
39TNK21.19260108
40RPS6KA21.15823907
41RPS6KC11.15342780
42RPS6KL11.15342780
43CSK1.11246818
44CDC42BPA1.09727713
45ERN11.03363987
46SIK11.02798382
47MAP3K71.02015837
48SIK21.01863983
49RPS6KA60.97970245
50DYRK30.97456933
51CHEK20.97043786
52PIM20.92556748
53ATR0.91182385
54RET0.89999791
55CAMK1D0.89298212
56MAP3K130.89003184
57MARK10.87712860
58PRKCH0.87614301
59PKN20.86400503
60PLK10.85356182
61PAK40.84893046
62RPS6KB20.83864309
63PHKG10.83029577
64PHKG20.83029577
65STK30.81606572
66ALK0.78999501
67PIM10.78530093
68MAPK120.77116109
69HIPK20.77106738
70RPS6KA10.76277407
71NTRK10.75774352
72ERBB30.75347545
73GSK3A0.74747081
74CDK20.74552178
75PAK20.73421783
76PDGFRB0.72010262
77NTRK30.71325219
78MAPK110.71178533
79CDK40.71117997
80FGFR10.69975762
81TRPM70.69826018
82CAMK40.65821406
83PTK20.65581562
84ERBB20.64968203
85PRKD30.64192907
86CAMK1G0.64174045
87PTK60.64059101
88CDK90.63966072
89CHEK10.63265421
90MKNK10.62493389
91DMPK0.62028636
92MAP2K60.61544547
93MAP2K20.60610218
94PDPK10.59897018
95PRKAA10.58176382
96IRAK30.56298987
97TTK0.55441888
98DAPK20.53563233
99MAPK80.53270091
100BTK0.53215146
101ATM0.53157298
102RIPK40.51396255
103CDK10.51205857
104WNK10.50999036
105MAPK10.49360892
106MAPK140.48819726
107NTRK20.48380970
108SGK30.47937411
109DYRK20.47870005
110AKT20.47852979
111NEK10.46824691
112AKT30.46641386
113MAPK30.45621662
114TAOK20.45235314
115MAPK40.45113231
116MARK20.44599217
117CSF1R0.42527571
118KSR20.42526487
119TTN0.42506752
120MKNK20.41196249
121RPS6KB10.41050049
122MAP2K40.40963026
123TGFBR10.40946867
124CDK30.40592519
125FGFR20.40206925
126AKT10.40030899
127GSK3B0.39727605
128SGK4940.39237017
129SGK2230.39237017
130MAPK100.38792627
131CDK80.37910508
132MAPK70.37322220
133MAP3K10.37030623
134WEE10.36942024
135CSNK1G10.36650126
136MOS0.36528466
137PAK60.36452258
138SCYL20.36023092
139TAOK10.35976624
140EPHA20.34289618
141MAPK90.34151569
142AURKB0.33737801
143EGFR0.32206059
144PRKDC0.31754199

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.40972370
2Base excision repair_Homo sapiens_hsa034103.33789777
3Mismatch repair_Homo sapiens_hsa034303.31351255
4DNA replication_Homo sapiens_hsa030302.94240367
5Notch signaling pathway_Homo sapiens_hsa043302.67416103
6Basal cell carcinoma_Homo sapiens_hsa052172.61794793
7Hedgehog signaling pathway_Homo sapiens_hsa043402.55305263
8Hippo signaling pathway_Homo sapiens_hsa043902.42899892
9mRNA surveillance pathway_Homo sapiens_hsa030152.37371422
10Spliceosome_Homo sapiens_hsa030402.23027528
11mTOR signaling pathway_Homo sapiens_hsa041502.16066895
12Lysine degradation_Homo sapiens_hsa003102.07173432
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06738037
14Adherens junction_Homo sapiens_hsa045202.00615312
15Other glycan degradation_Homo sapiens_hsa005111.98546823
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.93834160
17Cell cycle_Homo sapiens_hsa041101.86130366
18RNA transport_Homo sapiens_hsa030131.86064420
19MicroRNAs in cancer_Homo sapiens_hsa052061.67907692
20Wnt signaling pathway_Homo sapiens_hsa043101.63888180
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63208795
22Nucleotide excision repair_Homo sapiens_hsa034201.58460993
23Bladder cancer_Homo sapiens_hsa052191.53441855
24TGF-beta signaling pathway_Homo sapiens_hsa043501.51430464
25Phospholipase D signaling pathway_Homo sapiens_hsa040721.51212487
26Colorectal cancer_Homo sapiens_hsa052101.51002845
27Chronic myeloid leukemia_Homo sapiens_hsa052201.47177963
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45869684
29Long-term potentiation_Homo sapiens_hsa047201.44195436
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.43153023
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.43101216
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41427985
33Fanconi anemia pathway_Homo sapiens_hsa034601.29452690
34Homologous recombination_Homo sapiens_hsa034401.29372531
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28605556
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25644906
37Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.25261799
38p53 signaling pathway_Homo sapiens_hsa041151.24435591
39Endometrial cancer_Homo sapiens_hsa052131.23047155
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22848826
41Cholinergic synapse_Homo sapiens_hsa047251.22360441
42Small cell lung cancer_Homo sapiens_hsa052221.21521577
43Cocaine addiction_Homo sapiens_hsa050301.20102873
44Oocyte meiosis_Homo sapiens_hsa041141.19845325
45B cell receptor signaling pathway_Homo sapiens_hsa046621.17727844
46Proteoglycans in cancer_Homo sapiens_hsa052051.14940751
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12687791
48Circadian rhythm_Homo sapiens_hsa047101.08528555
49VEGF signaling pathway_Homo sapiens_hsa043701.06037325
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03910637
51Tight junction_Homo sapiens_hsa045301.03319529
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.02717015
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02117844
54Glutamatergic synapse_Homo sapiens_hsa047241.01983758
55Thyroid cancer_Homo sapiens_hsa052161.01367828
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00579031
57Oxytocin signaling pathway_Homo sapiens_hsa049211.00551479
58ErbB signaling pathway_Homo sapiens_hsa040120.99402239
59Type II diabetes mellitus_Homo sapiens_hsa049300.99292322
60Viral myocarditis_Homo sapiens_hsa054160.98961098
61Focal adhesion_Homo sapiens_hsa045100.98899923
62Gap junction_Homo sapiens_hsa045400.96885442
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95587033
64Inositol phosphate metabolism_Homo sapiens_hsa005620.95284651
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95193250
66AMPK signaling pathway_Homo sapiens_hsa041520.93771301
67Prolactin signaling pathway_Homo sapiens_hsa049170.93518490
68Dorso-ventral axis formation_Homo sapiens_hsa043200.93329948
69Circadian entrainment_Homo sapiens_hsa047130.92592515
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91850192
71Prion diseases_Homo sapiens_hsa050200.91692136
72Biosynthesis of amino acids_Homo sapiens_hsa012300.91128501
73Pathways in cancer_Homo sapiens_hsa052000.88471839
74Gastric acid secretion_Homo sapiens_hsa049710.88434199
75Axon guidance_Homo sapiens_hsa043600.88242488
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87411094
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85314842
78Acute myeloid leukemia_Homo sapiens_hsa052210.83371411
79One carbon pool by folate_Homo sapiens_hsa006700.82267328
80Calcium signaling pathway_Homo sapiens_hsa040200.82183301
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82095426
82Platelet activation_Homo sapiens_hsa046110.81596476
83HTLV-I infection_Homo sapiens_hsa051660.81198093
84Dopaminergic synapse_Homo sapiens_hsa047280.80418823
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.80026135
86Nicotine addiction_Homo sapiens_hsa050330.79200537
87Amoebiasis_Homo sapiens_hsa051460.78134611
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77882151
89Insulin signaling pathway_Homo sapiens_hsa049100.77474726
90Non-small cell lung cancer_Homo sapiens_hsa052230.77147893
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77133857
92Long-term depression_Homo sapiens_hsa047300.76906654
93Melanogenesis_Homo sapiens_hsa049160.76147911
94Amphetamine addiction_Homo sapiens_hsa050310.75232906
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74513108
96Morphine addiction_Homo sapiens_hsa050320.73396638
97Glioma_Homo sapiens_hsa052140.73310367
98Arginine and proline metabolism_Homo sapiens_hsa003300.69061646
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68195339
100Prostate cancer_Homo sapiens_hsa052150.68069614
101Insulin secretion_Homo sapiens_hsa049110.67361627
102Synaptic vesicle cycle_Homo sapiens_hsa047210.67221935
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66731701
104Fatty acid metabolism_Homo sapiens_hsa012120.66689193
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66628590
106Choline metabolism in cancer_Homo sapiens_hsa052310.66330062
107Viral carcinogenesis_Homo sapiens_hsa052030.66238859
108Shigellosis_Homo sapiens_hsa051310.65989742
109cAMP signaling pathway_Homo sapiens_hsa040240.64478454
110Salivary secretion_Homo sapiens_hsa049700.63476097
111ECM-receptor interaction_Homo sapiens_hsa045120.61434917
112Pancreatic cancer_Homo sapiens_hsa052120.60913055
113GABAergic synapse_Homo sapiens_hsa047270.60780986
114Renin secretion_Homo sapiens_hsa049240.60732100
115Thyroid hormone synthesis_Homo sapiens_hsa049180.60455763
116Estrogen signaling pathway_Homo sapiens_hsa049150.59999649
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58793651
118Rap1 signaling pathway_Homo sapiens_hsa040150.58776409
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57873045
120Melanoma_Homo sapiens_hsa052180.57582922
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55235699
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53942596
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52722343
124RNA degradation_Homo sapiens_hsa030180.52707188
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.50105331
126MAPK signaling pathway_Homo sapiens_hsa040100.47345740
127Sulfur relay system_Homo sapiens_hsa041220.44059087
128Arginine biosynthesis_Homo sapiens_hsa002200.40385158
129GnRH signaling pathway_Homo sapiens_hsa049120.36701857
130Hepatitis B_Homo sapiens_hsa051610.36421051
131Glucagon signaling pathway_Homo sapiens_hsa049220.35648754
132FoxO signaling pathway_Homo sapiens_hsa040680.34577900
133HIF-1 signaling pathway_Homo sapiens_hsa040660.33818976
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33117308
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31846719
136Herpes simplex infection_Homo sapiens_hsa051680.31805044
137Dilated cardiomyopathy_Homo sapiens_hsa054140.31704940
138Basal transcription factors_Homo sapiens_hsa030220.28443392
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28016280
140Selenocompound metabolism_Homo sapiens_hsa004500.26204733
141Renal cell carcinoma_Homo sapiens_hsa052110.25736179
142Insulin resistance_Homo sapiens_hsa049310.24125389
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23415818

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