BAIAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This p53-target gene encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. It interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. This protein also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.84030305
2cilium or flagellum-dependent cell motility (GO:0001539)7.97941572
3cilium movement (GO:0003341)7.44481247
4motile cilium assembly (GO:0044458)7.03401798
5epithelial cilium movement (GO:0003351)6.44731664
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.41283016
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.85128786
8synaptic vesicle maturation (GO:0016188)5.37238176
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.36091820
10axoneme assembly (GO:0035082)5.21069207
11positive regulation of synaptic transmission, GABAergic (GO:0032230)4.97820863
12regulation of synaptic vesicle exocytosis (GO:2000300)4.87700155
13COPI coating of Golgi vesicle (GO:0048205)4.69703963
14Golgi transport vesicle coating (GO:0048200)4.69703963
15neuromuscular process controlling posture (GO:0050884)4.46281331
16left/right pattern formation (GO:0060972)4.37908895
17locomotory exploration behavior (GO:0035641)4.36407638
18regulation of synaptic vesicle transport (GO:1902803)4.35250843
19cerebellar Purkinje cell layer development (GO:0021680)4.31490019
20activation of protein kinase A activity (GO:0034199)4.26185902
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.24319936
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.15086071
23gamma-aminobutyric acid transport (GO:0015812)4.03453410
24ventricular system development (GO:0021591)3.97792642
25synaptic vesicle exocytosis (GO:0016079)3.96890031
26cerebellar granule cell differentiation (GO:0021707)3.96771494
27peptide hormone processing (GO:0016486)3.92183559
28regulation of beta-amyloid formation (GO:1902003)3.88710034
29insulin secretion (GO:0030073)3.83659491
30positive regulation of synapse maturation (GO:0090129)3.79829061
31microtubule bundle formation (GO:0001578)3.73714326
32* neurotransmitter secretion (GO:0007269)3.72119146
33response to dietary excess (GO:0002021)3.69061564
34regulation of calcium ion-dependent exocytosis (GO:0017158)3.67510660
35neuron cell-cell adhesion (GO:0007158)3.66997694
36glycine transport (GO:0015816)3.62645252
37regulation of synapse structural plasticity (GO:0051823)3.58258538
38synaptic transmission, glutamatergic (GO:0035249)3.55985994
39vocalization behavior (GO:0071625)3.54902870
40regulation of amyloid precursor protein catabolic process (GO:1902991)3.52449402
41positive regulation of insulin secretion (GO:0032024)3.49671224
42lung epithelium development (GO:0060428)3.48776455
43vesicle transport along microtubule (GO:0047496)3.47190690
44L-amino acid import (GO:0043092)3.47104689
45glutamate secretion (GO:0014047)3.46646193
46cellular response to glucagon stimulus (GO:0071377)3.45831875
47positive regulation of amino acid transport (GO:0051957)3.43416606
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39223469
49protein localization to cilium (GO:0061512)3.37722391
50axon ensheathment in central nervous system (GO:0032291)3.36870195
51central nervous system myelination (GO:0022010)3.36870195
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33275675
53endocrine pancreas development (GO:0031018)3.30003016
54regulation of insulin secretion (GO:0050796)3.29624532
55positive regulation of membrane potential (GO:0045838)3.29019269
56regulation of cilium movement (GO:0003352)3.28139353
57proline transport (GO:0015824)3.27300385
58* neurotransmitter transport (GO:0006836)3.27029264
59response to pheromone (GO:0019236)3.24938527
60regulation of glutamate receptor signaling pathway (GO:1900449)3.24777634
61regulation of vesicle fusion (GO:0031338)3.23084161
62protein maturation by protein folding (GO:0022417)3.21021619
63positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20852977
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20842661
65cellular potassium ion homeostasis (GO:0030007)3.20505756
66detection of calcium ion (GO:0005513)3.20441388
67potassium ion homeostasis (GO:0055075)3.19520745
68regulation of synaptic plasticity (GO:0048167)3.18855479
69regulation of neuronal synaptic plasticity (GO:0048168)3.17614281
70exploration behavior (GO:0035640)3.16976925
71positive regulation of growth hormone secretion (GO:0060124)3.15978216
72synaptic vesicle endocytosis (GO:0048488)3.13795049
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13395427
74peptidyl-tyrosine autophosphorylation (GO:0038083)3.13156154
75suckling behavior (GO:0001967)3.11345199
76positive regulation of peptide hormone secretion (GO:0090277)3.11285187
77regulation of neurotransmitter secretion (GO:0046928)3.10346535
78regulation of voltage-gated calcium channel activity (GO:1901385)3.09273020
79potassium ion import (GO:0010107)3.09209053
80positive regulation of peptide secretion (GO:0002793)3.08290504
81glutamate receptor signaling pathway (GO:0007215)3.08168345
82sodium ion export (GO:0071436)3.08146047
83regulation of peptide hormone secretion (GO:0090276)3.07762465
84membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.07752178
85intraciliary transport (GO:0042073)3.07613162
86layer formation in cerebral cortex (GO:0021819)3.07555964
87dendritic spine organization (GO:0097061)3.07330784
88regulation of glucocorticoid secretion (GO:2000849)3.04469665
89regulation of peptide secretion (GO:0002791)3.04376165
90postsynaptic membrane organization (GO:0001941)3.03961086
91negative regulation of inclusion body assembly (GO:0090084)3.02886194
92transmission of nerve impulse (GO:0019226)3.02818140
93neuron-neuron synaptic transmission (GO:0007270)3.02735565
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02496135
95auditory behavior (GO:0031223)3.01699268
96regulation of exocytosis (GO:0017157)3.01386309
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.01028683
98chemosensory behavior (GO:0007635)3.00784530
99axon cargo transport (GO:0008088)2.99208240
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.98479761
101positive regulation of neurotransmitter transport (GO:0051590)2.98312959
102peptide hormone secretion (GO:0030072)2.97974471
103cilium organization (GO:0044782)2.97316386
104regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97212828
105one-carbon compound transport (GO:0019755)2.96799876
106positive regulation of exocytosis (GO:0045921)2.96225146
107ionotropic glutamate receptor signaling pathway (GO:0035235)2.96100755
108amino acid import (GO:0043090)2.95624331
109regulation of synaptic transmission, GABAergic (GO:0032228)2.95398195
110cilium assembly (GO:0042384)2.95100265
111regulation of synapse maturation (GO:0090128)2.93192452
112dendritic spine morphogenesis (GO:0060997)2.92712150
113organelle transport along microtubule (GO:0072384)2.92648277
114neuronal action potential propagation (GO:0019227)2.92550381
115* signal release (GO:0023061)2.92436447
116cell communication by electrical coupling (GO:0010644)2.90140884
117microtubule-based movement (GO:0007018)2.89964032
118regulation of transmission of nerve impulse (GO:0051969)2.89106805
119peptide secretion (GO:0002790)2.88133073
120cerebellar Purkinje cell differentiation (GO:0021702)2.88080144
121positive regulation of neurotransmitter secretion (GO:0001956)2.86764466
122regulation of microtubule-based movement (GO:0060632)2.86352265
123regulation of norepinephrine secretion (GO:0014061)2.85886469
124regulation of neurotransmitter transport (GO:0051588)2.85869317
125sperm capacitation (GO:0048240)2.85646337
126neuronal ion channel clustering (GO:0045161)2.85607409
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84467341
128positive regulation of dendritic spine development (GO:0060999)2.82804153
129positive regulation of potassium ion transmembrane transport (GO:1901381)2.82403969
130neuron recognition (GO:0008038)2.80975213
131* regulation of neurotransmitter levels (GO:0001505)2.80954870
132positive regulation of vesicle fusion (GO:0031340)2.80775466
133regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78899639
134response to parathyroid hormone (GO:0071107)2.78628164
135primary alcohol catabolic process (GO:0034310)2.77546240
136regulation of ARF protein signal transduction (GO:0032012)2.76021291
137type B pancreatic cell development (GO:0003323)2.75500097
138protein localization to synapse (GO:0035418)2.75384231
139regulation of postsynaptic membrane potential (GO:0060078)2.74825151
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74125690
141neuromuscular process controlling balance (GO:0050885)2.73796312
142mating behavior (GO:0007617)2.72827195
143membrane repolarization during action potential (GO:0086011)2.72803806
144positive regulation of potassium ion transport (GO:0043268)2.72617501
145positive regulation of amine transport (GO:0051954)2.71226133
146cellular sodium ion homeostasis (GO:0006883)2.70174579
147protein retention in ER lumen (GO:0006621)2.69044810
148regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.68152573
149vesicle coating (GO:0006901)2.68007660
150regulation of growth hormone secretion (GO:0060123)2.67977552
151negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.67672475
152long-term memory (GO:0007616)2.67254753
153neurotransmitter-gated ion channel clustering (GO:0072578)2.67003336
154calcium ion-dependent exocytosis (GO:0017156)2.66734342
155regulation of hormone secretion (GO:0046883)2.66106713
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.65854408
157regulation of dendritic spine morphogenesis (GO:0061001)2.65550991
158negative regulation of B cell mediated immunity (GO:0002713)2.64224869
159negative regulation of immunoglobulin mediated immune response (GO:0002890)2.64224869
160membrane depolarization during action potential (GO:0086010)2.63845861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.52661656
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50407745
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.48972009
4REST_21632747_ChIP-Seq_MESCs_Mouse3.21992358
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.02001203
6REST_18959480_ChIP-ChIP_MESCs_Mouse2.76309416
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67037859
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66852871
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.65290893
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61050380
11DROSHA_22980978_ChIP-Seq_HELA_Human2.50016884
12IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46629332
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.44191183
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39725628
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38349509
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34201442
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.31452078
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31256129
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30897152
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.23779286
21GBX2_23144817_ChIP-Seq_PC3_Human2.22538261
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20762705
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.17717236
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.06311444
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04583039
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02220682
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00784094
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00784094
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96448678
30ZNF274_21170338_ChIP-Seq_K562_Hela1.86745188
31IGF1R_20145208_ChIP-Seq_DFB_Human1.82553964
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.81671178
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78880120
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.78195184
35* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77825513
36LXR_22292898_ChIP-Seq_THP-1_Human1.74122632
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65706209
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.57490473
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56388526
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.55345042
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48417943
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.45679364
43P68_20966046_ChIP-Seq_HELA_Human1.45389466
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.42813694
45PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40550477
46SMAD4_21799915_ChIP-Seq_A2780_Human1.37193829
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33962602
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30150155
49OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28020724
50CREB1_26743006_Chip-Seq_LNCaP_Human1.27648030
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26995495
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26784008
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.26144651
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26034167
55STAT3_23295773_ChIP-Seq_U87_Human1.21809693
56AR_19668381_ChIP-Seq_PC3_Human1.21099792
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18189478
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16224630
59CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15765940
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15460595
61OCT4_19829295_ChIP-Seq_ESCs_Human1.11641417
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.11481558
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11314920
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10517301
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10026818
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.09953518
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09072055
68* KDM2B_26808549_Chip-Seq_K562_Human1.07889086
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06726059
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05603228
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04889416
72TP63_22573176_ChIP-Seq_HFKS_Human1.04593164
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04293937
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.00594214
75TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00549714
76ELF1_20517297_ChIP-Seq_JURKAT_Human0.99721722
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98514695
78* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98466083
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98254205
80* SA1_27219007_Chip-Seq_ERYTHROID_Human0.98171029
81CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97556280
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.96844550
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96771212
84* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96299087
85CTCF_20526341_ChIP-Seq_ESCs_Human0.96211735
86TCF4_23295773_ChIP-Seq_U87_Human0.95048491
87* CTCF_27219007_Chip-Seq_Bcells_Human0.94913070
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94041302
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93981014
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93643459
91TAF15_26573619_Chip-Seq_HEK293_Human0.92426824
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92363887
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92160115
94RACK7_27058665_Chip-Seq_MCF-7_Human0.92070416
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90896867
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90639676
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90536370
98PHF8_20622854_ChIP-Seq_HELA_Human0.89391592
99AR_21572438_ChIP-Seq_LNCaP_Human0.89278723
100RNF2_27304074_Chip-Seq_NSC_Mouse0.88771322
101TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88651667
102REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88641014
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88039504
104TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87584332
105* KDM2B_26808549_Chip-Seq_DND41_Human0.87130322
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86999510
107P300_19829295_ChIP-Seq_ESCs_Human0.86965258
108KLF4_19829295_ChIP-Seq_ESCs_Human0.86810799
109AR_25329375_ChIP-Seq_VCAP_Human0.86761463
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85843652
111SA1_27219007_Chip-Seq_Bcells_Human0.85609670
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85416257
113SMAD3_21741376_ChIP-Seq_EPCs_Human0.84603220
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.84388317
115SMC4_20622854_ChIP-Seq_HELA_Human0.84284726
116BCOR_27268052_Chip-Seq_Bcells_Human0.84236045
117MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.83106430
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82623816
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.82603598
120* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82566686
121GATA1_22025678_ChIP-Seq_K562_Human0.82390564
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.82254232
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82193633
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.81854969
125GATA1_26923725_Chip-Seq_HPCs_Mouse0.81541931
126RUNX2_22187159_ChIP-Seq_PCA_Human0.81447067
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81425734
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81092425
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.81090153
130E2F1_20622854_ChIP-Seq_HELA_Human0.80444836
131GATA1_19941826_ChIP-Seq_K562_Human0.80377598
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80252402
133SMAD4_21741376_ChIP-Seq_ESCs_Human0.80119716
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.79931607
135ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79658548
136CBX2_27304074_Chip-Seq_ESCs_Mouse0.79462889
137TP53_23651856_ChIP-Seq_MEFs_Mouse0.78970902
138EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78132944
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.77315020
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.76465851
141TP53_20018659_ChIP-ChIP_R1E_Mouse0.74949585
142BCL6_27268052_Chip-Seq_Bcells_Human0.73993103
143TRIM28_21343339_ChIP-Seq_HEK293_Human0.73754116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.15036588
2MP0005645_abnormal_hypothalamus_physiol3.91370608
3MP0003283_abnormal_digestive_organ3.56821251
4MP0004859_abnormal_synaptic_plasticity3.49634572
5MP0002909_abnormal_adrenal_gland3.48457255
6MP0003880_abnormal_central_pattern3.46412568
7MP0000013_abnormal_adipose_tissue3.25220195
8MP0002653_abnormal_ependyma_morphology2.98011759
9MP0003635_abnormal_synaptic_transmissio2.92437541
10MP0005423_abnormal_somatic_nervous2.75730381
11MP0004270_analgesia2.73593747
12MP0005379_endocrine/exocrine_gland_phen2.72041766
13MP0009780_abnormal_chondrocyte_physiolo2.64924954
14MP0003787_abnormal_imprinting2.60712391
15MP0009745_abnormal_behavioral_response2.39222383
16MP0003123_paternal_imprinting2.38202175
17MP0002064_seizures2.37382676
18MP0005646_abnormal_pituitary_gland2.23615322
19MP0002693_abnormal_pancreas_physiology2.19980230
20MP0009046_muscle_twitch2.15381703
21MP0006276_abnormal_autonomic_nervous2.10545584
22MP0001944_abnormal_pancreas_morphology2.09873879
23MP0004043_abnormal_pH_regulation2.09548552
24MP0002063_abnormal_learning/memory/cond2.06264256
25MP0002572_abnormal_emotion/affect_behav2.04402861
26MP0002734_abnormal_mechanical_nocicepti1.97717041
27MP0002272_abnormal_nervous_system1.94214808
28MP0001968_abnormal_touch/_nociception1.93266543
29MP0002733_abnormal_thermal_nociception1.89981947
30MP0002638_abnormal_pupillary_reflex1.89869075
31MP0003121_genomic_imprinting1.89621318
32MP0008961_abnormal_basal_metabolism1.89328912
33MP0000566_synostosis1.86637666
34MP0001501_abnormal_sleep_pattern1.84867345
35MP0010386_abnormal_urinary_bladder1.82782066
36MP0008875_abnormal_xenobiotic_pharmacok1.81099843
37MP0002877_abnormal_melanocyte_morpholog1.69908441
38MP0003183_abnormal_peptide_metabolism1.69558163
39MP0000003_abnormal_adipose_tissue1.65718771
40MP0001970_abnormal_pain_threshold1.64832831
41MP0002163_abnormal_gland_morphology1.64647544
42MP0006072_abnormal_retinal_apoptosis1.60596129
43MP0004133_heterotaxia1.59808017
44MP0001502_abnormal_circadian_rhythm1.54610921
45MP0003195_calcinosis1.52539772
46MP0003172_abnormal_lysosome_physiology1.48192482
47MP0001486_abnormal_startle_reflex1.47409914
48MP0001986_abnormal_taste_sensitivity1.46269021
49MP0002557_abnormal_social/conspecific_i1.46135967
50MP0002078_abnormal_glucose_homeostasis1.43201616
51MP0002067_abnormal_sensory_capabilities1.42928152
52MP0001440_abnormal_grooming_behavior1.36233556
53MP0002184_abnormal_innervation1.35546999
54MP0005623_abnormal_meninges_morphology1.35413756
55MP0003329_amyloid_beta_deposits1.33117502
56MP0002837_dystrophic_cardiac_calcinosis1.32872484
57MP0000955_abnormal_spinal_cord1.32393697
58MP0005377_hearing/vestibular/ear_phenot1.28866364
59MP0003878_abnormal_ear_physiology1.28866364
60MP0000631_abnormal_neuroendocrine_gland1.26468154
61MP0005386_behavior/neurological_phenoty1.24846062
62MP0004924_abnormal_behavior1.24846062
63MP0008569_lethality_at_weaning1.22229727
64MP0003959_abnormal_lean_body1.22060957
65MP0004145_abnormal_muscle_electrophysio1.21939728
66MP0004811_abnormal_neuron_physiology1.21113188
67MP0001529_abnormal_vocalization1.19154854
68MP0003879_abnormal_hair_cell1.17777680
69MP0003633_abnormal_nervous_system1.15263837
70MP0004142_abnormal_muscle_tone1.14874258
71MP0000678_abnormal_parathyroid_gland1.13987126
72MP0002736_abnormal_nociception_after1.13113093
73MP0004885_abnormal_endolymph1.12965551
74MP0001984_abnormal_olfaction1.12891577
75MP0001963_abnormal_hearing_physiology1.10000346
76MP0002066_abnormal_motor_capabilities/c1.08803594
77MP0005535_abnormal_body_temperature1.07110332
78MP0002069_abnormal_eating/drinking_beha1.06632959
79MP0001485_abnormal_pinna_reflex1.04624673
80MP0003953_abnormal_hormone_level1.03380244
81MP0005499_abnormal_olfactory_system1.02719926
82MP0005394_taste/olfaction_phenotype1.02719926
83MP0002882_abnormal_neuron_morphology1.00911355
84MP0004742_abnormal_vestibular_system1.00838837
85MP0004858_abnormal_nervous_system1.00766561
86MP0001299_abnormal_eye_distance/1.00189837
87MP0002735_abnormal_chemical_nociception0.98588849
88MP0001188_hyperpigmentation0.98491236
89MP0003045_fibrosis0.97255320
90MP0002229_neurodegeneration0.96856512
91MP0002822_catalepsy0.92528339
92MP0008877_abnormal_DNA_methylation0.92138399
93MP0001765_abnormal_ion_homeostasis0.91833764
94MP0002234_abnormal_pharynx_morphology0.91755522
95MP0002249_abnormal_larynx_morphology0.91529486
96MP0002132_abnormal_respiratory_system0.90896377
97MP0000639_abnormal_adrenal_gland0.90695697
98MP0000778_abnormal_nervous_system0.88878434
99MP0004019_abnormal_vitamin_homeostasis0.88667209
100MP0000026_abnormal_inner_ear0.87573004
101MP0003634_abnormal_glial_cell0.85568271
102MP0005253_abnormal_eye_physiology0.85557924
103MP0003632_abnormal_nervous_system0.85222124
104MP0001346_abnormal_lacrimal_gland0.84863010
105MP0002928_abnormal_bile_duct0.82769855
106MP0001905_abnormal_dopamine_level0.82717874
107MP0003938_abnormal_ear_development0.82339430
108MP0005220_abnormal_exocrine_pancreas0.81149008
109MP0005448_abnormal_energy_balance0.79007839
110MP0003075_altered_response_to0.78929230
111MP0005058_abnormal_lysosome_morphology0.78041547
112MP0008874_decreased_physiological_sensi0.76416151
113MP0002152_abnormal_brain_morphology0.72775246
114MP0002277_abnormal_respiratory_mucosa0.72741687
115MP0003631_nervous_system_phenotype0.70792402
116MP0002752_abnormal_somatic_nervous0.69713041
117MP0003690_abnormal_glial_cell0.69475588
118MP0002876_abnormal_thyroid_physiology0.68804058
119MP0008789_abnormal_olfactory_epithelium0.68621805
120MP0000462_abnormal_digestive_system0.67073260
121MP0001177_atelectasis0.66928743
122MP0000604_amyloidosis0.62884957
123MP0001664_abnormal_digestion0.62547723
124MP0008872_abnormal_physiological_respon0.62000201
125MP0005551_abnormal_eye_electrophysiolog0.60978271
126MP0003861_abnormal_nervous_system0.60460776
127MP0000747_muscle_weakness0.59639623
128MP0005452_abnormal_adipose_tissue0.58946015
129MP0004085_abnormal_heartbeat0.57828289
130MP0000920_abnormal_myelination0.57176584

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.75283975
2Abnormal respiratory epithelium morphology (HP:0012253)8.65064878
3Abnormal respiratory motile cilium morphology (HP:0005938)8.65064878
4Abnormal respiratory motile cilium physiology (HP:0012261)8.55058008
5Abnormal ciliary motility (HP:0012262)8.42860352
6Dynein arm defect of respiratory motile cilia (HP:0012255)8.41197463
7Absent/shortened dynein arms (HP:0200106)8.41197463
8Rhinitis (HP:0012384)7.68719121
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)7.31824915
10Chronic bronchitis (HP:0004469)5.84572597
11Bronchiectasis (HP:0002110)5.46180455
12Nasal polyposis (HP:0100582)5.38315814
13Hyperinsulinemic hypoglycemia (HP:0000825)5.24640125
14Hypoglycemic seizures (HP:0002173)5.15326227
15Visual hallucinations (HP:0002367)4.87896025
16Abnormality of calcium-phosphate metabolism (HP:0100530)4.70175557
17Symptomatic seizures (HP:0011145)4.37680801
18Focal motor seizures (HP:0011153)4.37636365
19Abnormality of the nasal mucosa (HP:0000433)4.33763612
20Agitation (HP:0000713)4.22917925
21Papilledema (HP:0001085)3.94527387
22Supranuclear gaze palsy (HP:0000605)3.64195717
23Menstrual irregularities (HP:0000858)3.62738307
24Recurrent sinusitis (HP:0011108)3.56014279
25Infertility (HP:0000789)3.42570667
26Focal seizures (HP:0007359)3.37121087
27Abnormality of the pancreatic islet cells (HP:0006476)3.33768503
28Abnormality of endocrine pancreas physiology (HP:0012093)3.33768503
29Depression (HP:0000716)3.30818868
30Absence seizures (HP:0002121)3.30120694
31Hypercortisolism (HP:0001578)3.22175288
32Failure to thrive in infancy (HP:0001531)3.21655080
33Hypoglycemic coma (HP:0001325)3.19292345
34Pheochromocytoma (HP:0002666)3.17795276
35Hyperparathyroidism (HP:0000843)3.15403131
36Pancreatic islet-cell hyperplasia (HP:0004510)3.14488363
37Recurrent otitis media (HP:0000403)3.13553428
38Obstructive sleep apnea (HP:0002870)3.10609814
39Atelectasis (HP:0100750)3.09617412
40Chronic sinusitis (HP:0011109)3.07349680
41Anxiety (HP:0000739)3.05478131
42Large for gestational age (HP:0001520)3.02799535
43Atonic seizures (HP:0010819)3.01919862
44Hyperglycemia (HP:0003074)2.99319454
45Insulin-resistant diabetes mellitus (HP:0000831)2.97144071
46Ankle clonus (HP:0011448)2.96529660
47Bronchitis (HP:0012387)2.95671617
48Occipital encephalocele (HP:0002085)2.92804679
49Ketoacidosis (HP:0001993)2.89802106
50Neuroendocrine neoplasm (HP:0100634)2.84997138
51Generalized tonic-clonic seizures (HP:0002069)2.84634658
52Dialeptic seizures (HP:0011146)2.78543408
53Male infertility (HP:0003251)2.78193360
54EEG with generalized epileptiform discharges (HP:0011198)2.75922309
55Late onset (HP:0003584)2.74911716
56Myokymia (HP:0002411)2.71906429
57Hypsarrhythmia (HP:0002521)2.71604546
58Abnormal eating behavior (HP:0100738)2.69908217
59Increased circulating renin level (HP:0000848)2.67151728
60Epileptiform EEG discharges (HP:0011182)2.65796065
61Growth hormone excess (HP:0000845)2.60084653
62Ventricular fibrillation (HP:0001663)2.55509953
63Decreased circulating renin level (HP:0003351)2.55025621
64Torticollis (HP:0000473)2.53147682
65Neoplasm of the heart (HP:0100544)2.51568407
66Neurofibrillary tangles (HP:0002185)2.50534864
67Macroorchidism (HP:0000053)2.50264680
68Cystic liver disease (HP:0006706)2.49103298
69Diplopia (HP:0000651)2.47386380
70Abnormality of binocular vision (HP:0011514)2.47386380
71Sleep apnea (HP:0010535)2.47363554
72Postural instability (HP:0002172)2.45160389
73Truncal ataxia (HP:0002078)2.43077370
74Psychosis (HP:0000709)2.42947442
75True hermaphroditism (HP:0010459)2.42744715
76Pancreatic fibrosis (HP:0100732)2.41873056
77Retinal atrophy (HP:0001105)2.41071412
78Hemiparesis (HP:0001269)2.38839795
79Restlessness (HP:0000711)2.37677737
80Epileptic encephalopathy (HP:0200134)2.35206115
81Dysostosis multiplex (HP:0000943)2.34497562
82Hyperphosphatemia (HP:0002905)2.32818758
83Chronic otitis media (HP:0000389)2.32083351
84Progressive cerebellar ataxia (HP:0002073)2.31655867
85Insomnia (HP:0100785)2.30581084
86Hypokalemia (HP:0002900)2.30022077
87Polyphagia (HP:0002591)2.28036801
88Adrenal overactivity (HP:0002717)2.27045145
89Abnormality of renin-angiotensin system (HP:0000847)2.26976298
90Nephronophthisis (HP:0000090)2.25148707
91Hemiplegia (HP:0002301)2.24083799
92Hypoventilation (HP:0002791)2.22175294
93Mucopolysacchariduria (HP:0008155)2.18572052
94Urinary glycosaminoglycan excretion (HP:0003541)2.18572052
95Febrile seizures (HP:0002373)2.17898098
96Testicular neoplasm (HP:0010788)2.14993113
97Gait imbalance (HP:0002141)2.14002560
98Focal dystonia (HP:0004373)2.11494212
99Cerebral inclusion bodies (HP:0100314)2.09646582
100Molar tooth sign on MRI (HP:0002419)2.07884019
101Abnormality of midbrain morphology (HP:0002418)2.07884019
102Impaired smooth pursuit (HP:0007772)2.07357687
103Hyperactive renin-angiotensin system (HP:0000841)2.05513946
104Bradykinesia (HP:0002067)2.04682890
105Limb dystonia (HP:0002451)2.04515912
106Annular pancreas (HP:0001734)2.03418437
107Oligomenorrhea (HP:0000876)2.02310645
108Abnormality of polysaccharide metabolism (HP:0011012)2.01544607
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01544607
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01544607
111Chronic hepatic failure (HP:0100626)1.99679926
112Action tremor (HP:0002345)1.96357434
113Genetic anticipation (HP:0003743)1.96072928
114Craniofacial dystonia (HP:0012179)1.96014424
115Cortical visual impairment (HP:0100704)1.95263620
116Postural tremor (HP:0002174)1.95253258
117Spastic gait (HP:0002064)1.95185873
118Progressive inability to walk (HP:0002505)1.95106320
119Fetal akinesia sequence (HP:0001989)1.93415009
120Abnormal pancreas size (HP:0012094)1.92859838
121Mutism (HP:0002300)1.91300933
122Clonus (HP:0002169)1.90536694
123Pancreatic cysts (HP:0001737)1.89071341
124Type II lissencephaly (HP:0007260)1.88622978
125Akinesia (HP:0002304)1.88366944
126Hyperthyroidism (HP:0000836)1.86343817
127Cerebral aneurysm (HP:0004944)1.85828268
128Blue irides (HP:0000635)1.85364187
129Abnormality of potassium homeostasis (HP:0011042)1.84985623
130Abnormal EKG (HP:0003115)1.84829207
131Dysmetria (HP:0001310)1.84550164
132Tachypnea (HP:0002789)1.83456426
133Neuronal loss in central nervous system (HP:0002529)1.81086977
134Prominent metopic ridge (HP:0005487)1.80404335
135Tubulointerstitial nephritis (HP:0001970)1.80182610
136Deep palmar crease (HP:0006191)1.79703999
137Prolonged QT interval (HP:0001657)1.79628632
138Muscular hypotonia of the trunk (HP:0008936)1.78965026
139Polydipsia (HP:0001959)1.76382409
140Abnormal drinking behavior (HP:0030082)1.76382409
141Congenital glaucoma (HP:0001087)1.75667655
142Urinary bladder sphincter dysfunction (HP:0002839)1.75641024
143Poor suck (HP:0002033)1.73217615
144Medial flaring of the eyebrow (HP:0010747)1.72468447
145Drooling (HP:0002307)1.72147670
146Excessive salivation (HP:0003781)1.72147670
147Congenital primary aphakia (HP:0007707)1.71484240
148Urinary urgency (HP:0000012)1.70376481
149Bell-shaped thorax (HP:0001591)1.68524760
150Renal salt wasting (HP:0000127)1.67108371
151Intention tremor (HP:0002080)1.66806476
152Amblyopia (HP:0000646)1.64687989
153Impaired vibration sensation in the lower limbs (HP:0002166)1.63135887
154Status epilepticus (HP:0002133)1.61061400
155Hand muscle atrophy (HP:0009130)1.60858353
156Postaxial foot polydactyly (HP:0001830)1.60230421
157Abnormality of the renal medulla (HP:0100957)1.59196364
158Nonprogressive disorder (HP:0003680)1.56971198
159Nephropathy (HP:0000112)1.56913326
160Absent speech (HP:0001344)1.56499711
161Aplasia/Hypoplasia of the spleen (HP:0010451)1.53044789
162Asplenia (HP:0001746)1.52021258
163Taurodontia (HP:0000679)1.49030901
164Abnormality of permanent molar morphology (HP:0011071)1.49030901
165Abnormality of the dental root (HP:0006486)1.49030901
166Nephrogenic diabetes insipidus (HP:0009806)1.48863566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.62779206
2MAPK153.90214800
3INSRR3.68806666
4WNK33.53027470
5MAP3K92.92941116
6UHMK12.78949743
7NTRK12.40408856
8PASK2.39468323
9PRKD32.36601602
10NTRK22.35184623
11MAP3K122.35033589
12MAP3K42.19374245
13RIPK42.18833146
14MARK12.06871552
15PRKCH1.93713588
16HIPK21.93322391
17MAP3K11.87706024
18MAP3K21.82885867
19MINK11.76745615
20TAOK31.76679925
21PAK61.70076631
22WNK41.69271696
23KSR21.60751156
24MAP2K71.58825646
25SCYL21.57270678
26PAK31.42933365
27MAP2K41.37789248
28CAMKK21.31944476
29PNCK1.29979982
30CDC42BPA1.28942358
31CDK51.27846948
32TNK21.27741801
33TNIK1.25398165
34CAMKK11.22986870
35ARAF1.21422083
36FES1.20138580
37PLK21.16322916
38STK381.11902270
39EPHA21.09379813
40ALK1.07497185
41PIK3CG1.01080985
42EPHA31.01080142
43PRKD20.98658508
44MAP3K110.95685115
45WNK10.94049216
46PDGFRA0.93226452
47GRK50.92659525
48EPHB10.88176719
49MAP3K130.87820986
50TESK10.86224738
51PRKCG0.85175917
52FRK0.84118923
53MST40.82935643
54TAOK10.81870398
55MARK20.80167994
56PHKG10.79431755
57PHKG20.79431755
58ICK0.77317791
59RET0.74562545
60MAPK130.74343684
61MAPK120.73450517
62TRIB30.73036581
63FGFR20.72298847
64IRAK20.72097595
65BRSK10.71682675
66SGK4940.70877615
67SGK2230.70877615
68CDK190.70186601
69STK110.68289476
70PTK2B0.67976104
71TLK10.67845847
72SIK20.67787390
73CAMK2B0.67694684
74PDK10.66900806
75ERBB20.66238778
76CAMK2D0.65228363
77DAPK20.64763508
78CAMK2A0.64111975
79PRKCZ0.63428627
80FER0.61951277
81DYRK1A0.61775806
82MAP3K70.58385336
83ITK0.58011287
84CSNK1G20.57346156
85TYRO30.56855973
86PTK20.56705941
87CASK0.56048013
88OXSR10.55540758
89BRAF0.54500841
90GRK70.54447296
91MAPK100.53624543
92PKN10.53594696
93EPHA40.53094172
94MAP2K60.53028670
95CAMK1G0.52897729
96SGK30.52764882
97RPS6KA30.51202490
98BMPR20.50832529
99CDK140.50569367
100FYN0.49850128
101ROCK20.49183456
102CAMK10.48877839
103CAMK40.48186003
104ADRBK20.47229154
105PRKCI0.45389377
106NME10.45082350
107SGK10.44603860
108PRKD10.44244644
109DYRK1B0.44015693
110CDK150.43324272
111SGK20.43222452
112KSR10.43175955
113LMTK20.42623661
114CDK180.42359245
115NEK60.41723588
116PINK10.41422469
117PRKCE0.41137389
118ADRBK10.40988153
119RPS6KA20.40309894
120GRK60.39594510
121CDK11A0.37871271
122DAPK10.37832241
123JAK20.37331679
124PRKACG0.37098603
125LATS20.37019864
126CAMK2G0.36912917
127RIPK10.36201094
128JAK10.35060566
129PDPK10.34747822
130SIK10.34083824

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.64511555
2Insulin secretion_Homo sapiens_hsa049113.33053938
3Synaptic vesicle cycle_Homo sapiens_hsa047212.94607617
4GABAergic synapse_Homo sapiens_hsa047272.92924525
5Nicotine addiction_Homo sapiens_hsa050332.78118965
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.71432454
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.55165489
8Type I diabetes mellitus_Homo sapiens_hsa049402.43786964
9Type II diabetes mellitus_Homo sapiens_hsa049302.28761964
10Cocaine addiction_Homo sapiens_hsa050302.22846014
11Morphine addiction_Homo sapiens_hsa050322.15062870
12Circadian entrainment_Homo sapiens_hsa047132.07983854
13Amphetamine addiction_Homo sapiens_hsa050312.07344873
14Taste transduction_Homo sapiens_hsa047422.00356650
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99012744
16Protein export_Homo sapiens_hsa030601.95543060
17Vibrio cholerae infection_Homo sapiens_hsa051101.91370718
18Long-term potentiation_Homo sapiens_hsa047201.84665669
19Dopaminergic synapse_Homo sapiens_hsa047281.81503219
20Olfactory transduction_Homo sapiens_hsa047401.78414221
21Histidine metabolism_Homo sapiens_hsa003401.76964868
22Glutamatergic synapse_Homo sapiens_hsa047241.74543248
23Serotonergic synapse_Homo sapiens_hsa047261.58195917
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57865730
25Phenylalanine metabolism_Homo sapiens_hsa003601.56604694
26Collecting duct acid secretion_Homo sapiens_hsa049661.49031824
27Gastric acid secretion_Homo sapiens_hsa049711.48835108
28Cholinergic synapse_Homo sapiens_hsa047251.45872045
29Renin secretion_Homo sapiens_hsa049241.44022708
30Salivary secretion_Homo sapiens_hsa049701.41315111
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36679969
32Pancreatic secretion_Homo sapiens_hsa049721.32256247
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29349083
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27939178
35Estrogen signaling pathway_Homo sapiens_hsa049151.23754344
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21673587
37Long-term depression_Homo sapiens_hsa047301.14752808
38Vitamin B6 metabolism_Homo sapiens_hsa007501.14035744
39beta-Alanine metabolism_Homo sapiens_hsa004101.10341985
40Thyroid hormone synthesis_Homo sapiens_hsa049181.08990050
41Prion diseases_Homo sapiens_hsa050201.07528605
42GnRH signaling pathway_Homo sapiens_hsa049121.07306297
43cAMP signaling pathway_Homo sapiens_hsa040241.05073755
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99558546
45Gap junction_Homo sapiens_hsa045400.99483943
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97278740
47Oxytocin signaling pathway_Homo sapiens_hsa049210.97084500
48Calcium signaling pathway_Homo sapiens_hsa040200.94711213
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94041057
50Chemical carcinogenesis_Homo sapiens_hsa052040.90800178
51Lysosome_Homo sapiens_hsa041420.89732113
52Tyrosine metabolism_Homo sapiens_hsa003500.88043745
53Nitrogen metabolism_Homo sapiens_hsa009100.87568025
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87561188
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85884970
56Dorso-ventral axis formation_Homo sapiens_hsa043200.85335346
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.85087590
58Glucagon signaling pathway_Homo sapiens_hsa049220.84333722
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83701494
60Melanogenesis_Homo sapiens_hsa049160.79395258
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79271110
62Huntingtons disease_Homo sapiens_hsa050160.76916568
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76527461
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75686542
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74419217
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72588404
67Cardiac muscle contraction_Homo sapiens_hsa042600.71366799
68Circadian rhythm_Homo sapiens_hsa047100.69955321
69Alcoholism_Homo sapiens_hsa050340.68941808
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68586373
71Sulfur metabolism_Homo sapiens_hsa009200.68516126
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64584731
73VEGF signaling pathway_Homo sapiens_hsa043700.62659196
74Rap1 signaling pathway_Homo sapiens_hsa040150.59516692
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.59435657
76N-Glycan biosynthesis_Homo sapiens_hsa005100.59033481
77Tight junction_Homo sapiens_hsa045300.58149925
78Insulin signaling pathway_Homo sapiens_hsa049100.57825476
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56817474
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.54703226
81ErbB signaling pathway_Homo sapiens_hsa040120.54178655
82Dilated cardiomyopathy_Homo sapiens_hsa054140.54017009
83Phototransduction_Homo sapiens_hsa047440.53684515
84Notch signaling pathway_Homo sapiens_hsa043300.53543439
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53487582
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52483018
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.52267669
88Oocyte meiosis_Homo sapiens_hsa041140.51553215
89MAPK signaling pathway_Homo sapiens_hsa040100.51042432
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50387389
91Regulation of autophagy_Homo sapiens_hsa041400.49438477
92Prolactin signaling pathway_Homo sapiens_hsa049170.48432120
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.47684435
94Endocytosis_Homo sapiens_hsa041440.46282601
95Glioma_Homo sapiens_hsa052140.45839935
96Ovarian steroidogenesis_Homo sapiens_hsa049130.45231174
97Axon guidance_Homo sapiens_hsa043600.45199388
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43879822
99Inositol phosphate metabolism_Homo sapiens_hsa005620.43855674
100Bile secretion_Homo sapiens_hsa049760.42194459
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41762728
102Sphingolipid metabolism_Homo sapiens_hsa006000.41735877
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41694156
104Galactose metabolism_Homo sapiens_hsa000520.40985466
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40674093
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40287960
107Wnt signaling pathway_Homo sapiens_hsa043100.38917433
108Arginine and proline metabolism_Homo sapiens_hsa003300.38682993
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.38469800
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38109240
111ABC transporters_Homo sapiens_hsa020100.37795074
112Renal cell carcinoma_Homo sapiens_hsa052110.37498299
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35910923
114Ras signaling pathway_Homo sapiens_hsa040140.34383760
115Alzheimers disease_Homo sapiens_hsa050100.33724825
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33021561
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32948354
118mTOR signaling pathway_Homo sapiens_hsa041500.32236188
119Butanoate metabolism_Homo sapiens_hsa006500.31836570
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31014397
121Chemokine signaling pathway_Homo sapiens_hsa040620.28790150
122Choline metabolism in cancer_Homo sapiens_hsa052310.27229181

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