BAK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44874276
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44874276
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91725716
4positive regulation by organism of defense response of other organism involved in symbiotic interact3.91725716
5modulation by symbiont of host immune response (GO:0052553)3.91725716
6positive regulation by symbiont of host defense response (GO:0052509)3.91725716
7modulation by symbiont of host defense response (GO:0052031)3.91725716
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91725716
9antigen processing and presentation of endogenous antigen (GO:0019883)3.87551271
10NIK/NF-kappaB signaling (GO:0038061)3.87454300
11positive regulation of Cdc42 GTPase activity (GO:0043089)3.44454593
12cellular response to type I interferon (GO:0071357)3.39416177
13type I interferon signaling pathway (GO:0060337)3.39416177
14positive regulation of histone deacetylation (GO:0031065)3.35409285
15response to type I interferon (GO:0034340)3.34040829
16pentose-phosphate shunt (GO:0006098)3.28985754
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26738468
18COPI coating of Golgi vesicle (GO:0048205)3.24309303
19Golgi transport vesicle coating (GO:0048200)3.24309303
20regulation of interferon-beta biosynthetic process (GO:0045357)3.22593663
21heterochromatin organization (GO:0070828)3.21075989
22GDP-mannose metabolic process (GO:0019673)3.14904200
23neutrophil activation involved in immune response (GO:0002283)3.14895338
24negative regulation of cell killing (GO:0031342)3.09616867
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09616867
26DNA unwinding involved in DNA replication (GO:0006268)3.08808185
27regulation of translational fidelity (GO:0006450)3.08691784
28response to laminar fluid shear stress (GO:0034616)3.03022948
29detection of bacterium (GO:0016045)3.02984968
30detection of other organism (GO:0098543)2.95830155
31folic acid-containing compound biosynthetic process (GO:0009396)2.91656790
32positive regulation of interferon-alpha production (GO:0032727)2.90324787
33low-density lipoprotein particle clearance (GO:0034383)2.89294944
34protein maturation by protein folding (GO:0022417)2.88380490
35negative regulation of phagocytosis (GO:0050765)2.86693483
36glycosphingolipid catabolic process (GO:0046479)2.84783116
37NADPH regeneration (GO:0006740)2.83942645
38RNA stabilization (GO:0043489)2.82272099
39mRNA stabilization (GO:0048255)2.82272099
40myeloid dendritic cell differentiation (GO:0043011)2.82097799
41regulation of superoxide anion generation (GO:0032928)2.81901832
42modulation by symbiont of host cellular process (GO:0044068)2.80852684
43regulation of interferon-alpha production (GO:0032647)2.78706598
44maternal placenta development (GO:0001893)2.78310147
453-UTR-mediated mRNA stabilization (GO:0070935)2.75330365
46protein localization to kinetochore (GO:0034501)2.74995873
47positive regulation of SMAD protein import into nucleus (GO:0060391)2.74070884
48cellular response to virus (GO:0098586)2.73381591
49immunoglobulin mediated immune response (GO:0016064)2.72477374
50lipopolysaccharide-mediated signaling pathway (GO:0031663)2.69814143
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68227128
52regulation of integrin activation (GO:0033623)2.66709215
53hepatocyte apoptotic process (GO:0097284)2.64589812
54modulation by virus of host process (GO:0019054)2.61820991
55positive regulation of protein deacetylation (GO:0090312)2.59664144
56regulation of necrotic cell death (GO:0010939)2.59576139
57myeloid dendritic cell activation (GO:0001773)2.59231017
58positive regulation of gamma-delta T cell activation (GO:0046645)2.58781647
59glycolipid catabolic process (GO:0019377)2.56356649
60barbed-end actin filament capping (GO:0051016)2.54326411
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54124226
62interferon-gamma-mediated signaling pathway (GO:0060333)2.53842389
63regulation of SMAD protein import into nucleus (GO:0060390)2.53611454
64* negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52738937
65nuclear pore complex assembly (GO:0051292)2.51827604
66negative regulation of erythrocyte differentiation (GO:0045647)2.49961747
67negative regulation of interleukin-12 production (GO:0032695)2.49858823
68actin nucleation (GO:0045010)2.48747957
69regulation of defense response to virus by virus (GO:0050690)2.46484802
70positive regulation of lamellipodium assembly (GO:0010592)2.45441239
71macrophage activation involved in immune response (GO:0002281)2.44416432
72negative regulation of viral release from host cell (GO:1902187)2.44376894
73regulation of podosome assembly (GO:0071801)2.43867938
74mitotic nuclear envelope disassembly (GO:0007077)2.43597725
75germ cell migration (GO:0008354)2.43087512
76NADH metabolic process (GO:0006734)2.41486567
77pyrimidine-containing compound salvage (GO:0008655)2.41160822
78pyrimidine nucleoside salvage (GO:0043097)2.41160822
79tolerance induction (GO:0002507)2.40610349
80regulation of necroptotic process (GO:0060544)2.39872676
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39523121
82apoptotic cell clearance (GO:0043277)2.39384171
83cell adhesion mediated by integrin (GO:0033627)2.39160313
84amyloid precursor protein catabolic process (GO:0042987)2.38063746
85B cell mediated immunity (GO:0019724)2.37664958
86defense response to fungus (GO:0050832)2.36570162
87negative regulation of myeloid cell apoptotic process (GO:0033033)2.36489568
88response to host immune response (GO:0052572)2.36408311
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36408311
90regulation of vitamin metabolic process (GO:0030656)2.36105403
91embryonic process involved in female pregnancy (GO:0060136)2.35145409
92viral transcription (GO:0019083)2.34997057
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34216083
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.34075278
95response to host (GO:0075136)2.34075278
96response to host defenses (GO:0052200)2.34075278
97pinocytosis (GO:0006907)2.34073864
98regulation of interleukin-12 biosynthetic process (GO:0045075)2.32597254
99amino sugar catabolic process (GO:0046348)2.32546654
100negative regulation of cytokine production involved in immune response (GO:0002719)2.32208964
101nuclear pore organization (GO:0006999)2.31912586
102regulation of leukocyte degranulation (GO:0043300)2.31654792
103regulation of cellular extravasation (GO:0002691)2.31300011
104antigen processing and presentation via MHC class Ib (GO:0002475)2.31208346
105proline biosynthetic process (GO:0006561)2.31151605
106trophectodermal cell differentiation (GO:0001829)2.31140243
107skin morphogenesis (GO:0043589)2.29711456
108positive regulation of keratinocyte differentiation (GO:0045618)2.29178928
109chaperone mediated protein folding requiring cofactor (GO:0051085)2.28732869
110endothelial tube morphogenesis (GO:0061154)2.27471320
111morphogenesis of an endothelium (GO:0003159)2.27471320
112mannose metabolic process (GO:0006013)2.27089816
113leukocyte aggregation (GO:0070486)2.26452283
114positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.26278374
115protein localization to chromosome, centromeric region (GO:0071459)2.25995913
116membrane disassembly (GO:0030397)2.24988900
117nuclear envelope disassembly (GO:0051081)2.24988900
118response to interferon-beta (GO:0035456)2.24826813
119cortical actin cytoskeleton organization (GO:0030866)2.24098854
120interferon-gamma secretion (GO:0072643)2.23786053
121chromatin assembly (GO:0031497)2.23716390
122regulation of gamma-delta T cell differentiation (GO:0045586)2.23622092
123NLS-bearing protein import into nucleus (GO:0006607)2.23557735
124translational termination (GO:0006415)2.23517350
125L-alpha-amino acid transmembrane transport (GO:1902475)2.23132752
126response to peptidoglycan (GO:0032494)2.22793767
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.22561767
128regulation of cholesterol storage (GO:0010885)2.21989964
129glucose catabolic process (GO:0006007)2.21165510
130positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.21100133
131cell-substrate junction assembly (GO:0007044)2.21041249
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.20748974
133protein localization to endosome (GO:0036010)2.20349517
134positive regulation of lamellipodium organization (GO:1902745)2.19910088
135hyaluronan catabolic process (GO:0030214)2.19515061
136negative regulation of cell size (GO:0045792)2.19443747
137granulocyte activation (GO:0036230)2.19344730
138negative regulation of necroptotic process (GO:0060546)2.18714686
139response to muramyl dipeptide (GO:0032495)2.18400864
140endodermal cell differentiation (GO:0035987)2.18117473
141glucocorticoid receptor signaling pathway (GO:0042921)2.17913313
142regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.17840599
143regulation of vitamin D biosynthetic process (GO:0060556)2.17658284
144germinal center formation (GO:0002467)2.17635485
145leukocyte cell-cell adhesion (GO:0007159)2.17580605
146negative regulation of fatty acid transport (GO:2000192)2.17480974
147positive thymic T cell selection (GO:0045059)2.16138289
148detection of external biotic stimulus (GO:0098581)2.15905170
149regulation of RIG-I signaling pathway (GO:0039535)2.15695157
150positive regulation of chemokine biosynthetic process (GO:0045080)2.15673079
151pentose metabolic process (GO:0019321)2.15149788
152positive regulation of B cell differentiation (GO:0045579)2.14891940
153regulation of mast cell degranulation (GO:0043304)2.14860649
154establishment of endothelial barrier (GO:0061028)2.14507436
155respiratory burst (GO:0045730)2.13020793
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.12498476
157regulation of myeloid leukocyte mediated immunity (GO:0002886)2.12278917
158defense response to protozoan (GO:0042832)2.12218904
159regulation of translational termination (GO:0006449)2.11663588
160* apoptotic process involved in morphogenesis (GO:0060561)2.09566844
161positive regulation of interferon-beta production (GO:0032728)2.08701924
162natural killer cell differentiation (GO:0001779)2.08100447
163receptor catabolic process (GO:0032801)2.05365845
164regulation of gamma-delta T cell activation (GO:0046643)2.05322194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.21434359
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.85733148
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.41061139
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.29669891
5MYC_22102868_ChIP-Seq_BL_Human3.08365011
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.86145445
7VDR_21846776_ChIP-Seq_THP-1_Human2.69242091
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51382274
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.34839918
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.12773154
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10352682
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09931035
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.02245831
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95763918
15TCF7_22412390_ChIP-Seq_EML_Mouse1.94023776
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92052720
17BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90701334
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89755953
19MAF_26560356_Chip-Seq_TH1_Human1.86882758
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85812284
21VDR_24763502_ChIP-Seq_THP-1_Human1.77442306
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77211540
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77013791
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75909942
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74723803
26ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74130930
27UTX_26944678_Chip-Seq_JUKART_Human1.73578858
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71842397
29* KDM2B_26808549_Chip-Seq_DND41_Human1.68855653
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68223279
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.64544817
32E2F4_17652178_ChIP-ChIP_JURKAT_Human1.61657969
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60807354
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59435999
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59214348
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56631152
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56063863
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55412580
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53651370
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.52935232
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.52399010
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48903418
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47637705
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44496098
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.44304540
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43398620
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42964927
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41370930
49* MYB_26560356_Chip-Seq_TH2_Human1.40287524
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37652119
51SPI1_23547873_ChIP-Seq_NB4_Human1.36311842
52LXR_22292898_ChIP-Seq_THP-1_Human1.36181041
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35211993
54SCL_19346495_ChIP-Seq_HPC-7_Human1.34583887
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34502840
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.34179892
57RACK7_27058665_Chip-Seq_MCF-7_Human1.33348622
58ATF3_27146783_Chip-Seq_COLON_Human1.32623990
59MYB_26560356_Chip-Seq_TH1_Human1.32169961
60* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30706486
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29754066
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28560471
63CLOCK_20551151_ChIP-Seq_293T_Human1.27797607
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26207540
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25656737
66AR_21909140_ChIP-Seq_LNCAP_Human1.24774797
67* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24714752
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24346555
69SPI1_23127762_ChIP-Seq_K562_Human1.23339666
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22530013
71NCOR1_26117541_ChIP-Seq_K562_Human1.22402117
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21690465
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21348205
74P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21121778
75* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20723926
76BCOR_27268052_Chip-Seq_Bcells_Human1.20599392
77MAF_26560356_Chip-Seq_TH2_Human1.20061541
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19465318
79* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18946374
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17373709
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17262946
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16695515
83BCL6_27268052_Chip-Seq_Bcells_Human1.16103629
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15811119
85P68_20966046_ChIP-Seq_HELA_Human1.15323081
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.15149449
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15100151
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14768256
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14547903
90TFEB_21752829_ChIP-Seq_HELA_Human1.13740348
91E2F1_21310950_ChIP-Seq_MCF-7_Human1.13333150
92* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12584487
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11735662
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11230859
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11194591
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10511852
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10231144
98* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10099690
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08741298
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07916990
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07474882
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07272138
103* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07248245
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.07105021
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06854373
106* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05081150
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04659107
108GATA6_25053715_ChIP-Seq_YYC3_Human1.04220737
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.04050505
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01685562
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00944894
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00910496
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00108209
114XRN2_22483619_ChIP-Seq_HELA_Human0.99423947
115GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99102212
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98018516
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97722869
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.96128751
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95564477
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.95346939
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93900497
122TP53_22127205_ChIP-Seq_IMR90_Human0.92211061
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90584016
124CIITA_25753668_ChIP-Seq_RAJI_Human0.89972156
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89466801
126PU_27001747_Chip-Seq_BMDM_Mouse0.89171638
127ZNF263_19887448_ChIP-Seq_K562_Human0.88905381
128NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88245843
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87513915
130MYC_19030024_ChIP-ChIP_MESCs_Mouse0.87291747
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.86655416

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.54134681
2MP0010352_gastrointestinal_tract_polyps3.28097875
3MP0005451_abnormal_body_composition3.23475863
4MP0003303_peritoneal_inflammation3.18023367
5MP0003300_gastrointestinal_ulcer2.93231154
6MP0008260_abnormal_autophagy2.64093262
7MP0005076_abnormal_cell_differentiation2.42082064
8MP0003566_abnormal_cell_adhesion2.38443586
9MP0003436_decreased_susceptibility_to2.32514092
10MP0010307_abnormal_tumor_latency2.25657229
11MP0008438_abnormal_cutaneous_collagen2.18739497
12MP0009278_abnormal_bone_marrow2.04060707
13MP0009840_abnormal_foam_cell1.90237697
14MP0003806_abnormal_nucleotide_metabolis1.86839835
15MP0003724_increased_susceptibility_to1.84741466
16MP0001835_abnormal_antigen_presentation1.79510551
17MP0002796_impaired_skin_barrier1.78184360
18MP0005023_abnormal_wound_healing1.77319560
19MP0000685_abnormal_immune_system1.76408412
20MP0004947_skin_inflammation1.66052814
21MP0000490_abnormal_crypts_of1.64676250
22MP0006054_spinal_hemorrhage1.61603684
23MP0004808_abnormal_hematopoietic_stem1.58906406
24MP0004264_abnormal_extraembryonic_tissu1.53858239
25MP0006082_CNS_inflammation1.53280584
26* MP0002452_abnormal_antigen_presenting1.51338056
27MP0002396_abnormal_hematopoietic_system1.50951152
28MP0005387_immune_system_phenotype1.50538335
29MP0001790_abnormal_immune_system1.50538335
30MP0003448_altered_tumor_morphology1.49334403
31MP0010155_abnormal_intestine_physiology1.49329883
32* MP0001800_abnormal_humoral_immune1.49011746
33MP0005025_abnormal_response_to1.46477855
34MP0002419_abnormal_innate_immunity1.44818932
35MP0005397_hematopoietic_system_phenotyp1.44588448
36MP0001545_abnormal_hematopoietic_system1.44588448
37MP0000733_abnormal_muscle_development1.44336929
38MP0002877_abnormal_melanocyte_morpholog1.42502881
39MP0002405_respiratory_system_inflammati1.41068535
40MP0000858_altered_metastatic_potential1.40955105
41* MP0005000_abnormal_immune_tolerance1.39991690
42MP0001849_ear_inflammation1.39245876
43MP0003091_abnormal_cell_migration1.38678065
44MP0009785_altered_susceptibility_to1.36223352
45MP0001533_abnormal_skeleton_physiology1.35675037
46* MP0002398_abnormal_bone_marrow1.33956683
47MP0010234_abnormal_vibrissa_follicle1.33395202
48MP0003075_altered_response_to1.33289599
49MP0005501_abnormal_skin_physiology1.33227917
50MP0005058_abnormal_lysosome_morphology1.32185317
51* MP0001819_abnormal_immune_cell1.29639414
52* MP0002420_abnormal_adaptive_immunity1.29158239
53* MP0002723_abnormal_immune_serum1.26131435
54* MP0005464_abnormal_platelet_physiology1.26052892
55MP0003183_abnormal_peptide_metabolism1.25534694
56MP0003693_abnormal_embryo_hatching1.22981526
57MP0002166_altered_tumor_susceptibility1.21314477
58* MP0002722_abnormal_immune_system1.20718185
59* MP0009333_abnormal_splenocyte_physiolog1.20135374
60MP0003453_abnormal_keratinocyte_physiol1.19282988
61MP0004957_abnormal_blastocyst_morpholog1.19030375
62MP0005257_abnormal_intraocular_pressure1.17258577
63MP0003111_abnormal_nucleus_morphology1.16878198
64MP0001730_embryonic_growth_arrest1.16291451
65MP0001216_abnormal_epidermal_layer1.15966091
66* MP0000716_abnormal_immune_system1.15692788
67* MP0000689_abnormal_spleen_morphology1.14362181
68MP0003279_aneurysm1.13287042
69MP0003077_abnormal_cell_cycle1.12114510
70MP0000350_abnormal_cell_proliferation1.11270578
71MP0004510_myositis1.10460275
72* MP0002429_abnormal_blood_cell1.09891512
73MP0001873_stomach_inflammation1.08966053
74MP0005166_decreased_susceptibility_to1.07240376
75MP0001915_intracranial_hemorrhage1.05765131
76MP0000465_gastrointestinal_hemorrhage1.05640285
77MP0003172_abnormal_lysosome_physiology1.05409773
78MP0004858_abnormal_nervous_system1.04836937
79MP0000678_abnormal_parathyroid_gland1.04669585
80MP0005310_abnormal_salivary_gland1.03460497
81MP0002006_tumorigenesis1.03296582
82MP0004197_abnormal_fetal_growth/weight/1.02959117
83* MP0001845_abnormal_inflammatory_respons1.02663292
84MP0004185_abnormal_adipocyte_glucose1.02347780
85MP0001958_emphysema1.01574091
86MP0002086_abnormal_extraembryonic_tissu1.01346078
87MP0009053_abnormal_anal_canal0.99307032
88MP0000703_abnormal_thymus_morphology0.99218793
89MP0002148_abnormal_hypersensitivity_rea0.98559766
90MP0009764_decreased_sensitivity_to0.96947771
91MP0002139_abnormal_hepatobiliary_system0.96656495
92MP0002019_abnormal_tumor_incidence0.96591157
93MP0000343_altered_response_to0.96310007
94MP0005671_abnormal_response_to0.94180050
95MP0003984_embryonic_growth_retardation0.93882423
96MP0001853_heart_inflammation0.93840288
97MP0000604_amyloidosis0.93219012
98MP0002088_abnormal_embryonic_growth/wei0.92361599
99MP0000477_abnormal_intestine_morphology0.90232075
100MP0005275_abnormal_skin_tensile0.89988447
101MP0003866_abnormal_defecation0.88724261
102MP0001672_abnormal_embryogenesis/_devel0.85354469
103MP0005380_embryogenesis_phenotype0.85354469
104MP0005165_increased_susceptibility_to0.85262578
105MP0005623_abnormal_meninges_morphology0.85207207
106MP0002998_abnormal_bone_remodeling0.84742406
107MP0010094_abnormal_chromosome_stability0.83232964
108MP0005390_skeleton_phenotype0.81688261
109MP0002080_prenatal_lethality0.81425601
110MP0003763_abnormal_thymus_physiology0.80928428
111MP0003191_abnormal_cellular_cholesterol0.80548344
112MP0001697_abnormal_embryo_size0.80256683
113MP0002254_reproductive_system_inflammat0.78920997
114MP0000750_abnormal_muscle_regeneration0.78829920
115MP0003828_pulmonary_edema0.77795830
116MP0002925_abnormal_cardiovascular_devel0.77577353
117MP0000767_abnormal_smooth_muscle0.77552731
118MP0009931_abnormal_skin_appearance0.76785188
119MP0008469_abnormal_protein_level0.76305792
120MP0003329_amyloid_beta_deposits0.74473472
121MP0001663_abnormal_digestive_system0.73589566
122* MP0000313_abnormal_cell_death0.73402036
123MP0009763_increased_sensitivity_to0.73360074
124MP0002132_abnormal_respiratory_system0.72736204
125MP0008004_abnormal_stomach_pH0.72312997
126MP0005360_urolithiasis0.71880374
127MP0000609_abnormal_liver_physiology0.71748756
128MP0005319_abnormal_enzyme/_coenzyme0.71456031

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.44867716
2Increased density of long bones (HP:0006392)3.32936802
3Abnormality of glycolipid metabolism (HP:0010969)3.26948141
4Abnormality of liposaccharide metabolism (HP:0010968)3.26948141
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.26948141
6Eczematoid dermatitis (HP:0000976)3.24182247
7Cerebral aneurysm (HP:0004944)2.91264313
8Peritonitis (HP:0002586)2.89816062
9Recurrent abscess formation (HP:0002722)2.82880641
10Cellulitis (HP:0100658)2.78095888
11Premature rupture of membranes (HP:0001788)2.72082842
12Vacuolated lymphocytes (HP:0001922)2.68984855
13Autoimmune thrombocytopenia (HP:0001973)2.66457479
14Cervical subluxation (HP:0003308)2.65640978
15Increased IgM level (HP:0003496)2.62266242
16Loss of speech (HP:0002371)2.59170486
17Abnormal platelet volume (HP:0011876)2.52595525
18Ulnar bowing (HP:0003031)2.51624048
19Malnutrition (HP:0004395)2.50017406
20Shallow orbits (HP:0000586)2.48409307
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.48187730
22Systemic lupus erythematosus (HP:0002725)2.46960055
23Osteolytic defects of the hand bones (HP:0009699)2.42538237
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.42538237
25Ragged-red muscle fibers (HP:0003200)2.42493153
26Recurrent viral infections (HP:0004429)2.41200686
27Recurrent bacterial skin infections (HP:0005406)2.41200606
28Nasal polyposis (HP:0100582)2.35100651
29Ankle contracture (HP:0006466)2.34566048
30Colitis (HP:0002583)2.33110785
31Hepatosplenomegaly (HP:0001433)2.32840798
32Recurrent fungal infections (HP:0002841)2.30608006
33Increased mean platelet volume (HP:0011877)2.30420975
34Hypertensive crisis (HP:0100735)2.28266372
35Elevated erythrocyte sedimentation rate (HP:0003565)2.27680206
36Genu recurvatum (HP:0002816)2.26977798
37Gastrointestinal stroma tumor (HP:0100723)2.26970117
38Chronic otitis media (HP:0000389)2.24936083
39Interstitial pulmonary disease (HP:0006530)2.23973646
40Meningitis (HP:0001287)2.23831070
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.20361306
42Recurrent skin infections (HP:0001581)2.19713564
43Abnormality of the nasal mucosa (HP:0000433)2.15751258
44Abnormality of the peritoneum (HP:0002585)2.15509885
45Rough bone trabeculation (HP:0100670)2.15081852
46Myositis (HP:0100614)2.14991328
47Axonal loss (HP:0003447)2.13595763
48Hyperacusis (HP:0010780)2.12630971
49Purpura (HP:0000979)2.12500471
50Increased cerebral lipofuscin (HP:0011813)2.11379555
51Pustule (HP:0200039)2.10732966
52Dilatation of the ascending aorta (HP:0005111)2.10682554
53Polygenic inheritance (HP:0010982)2.10432027
54Distal lower limb amyotrophy (HP:0008944)2.09305452
55Thrombocytosis (HP:0001894)2.08955591
56Hypergammaglobulinemia (HP:0010702)2.08384949
57Cutaneous melanoma (HP:0012056)2.07441588
58Premature loss of primary teeth (HP:0006323)2.07070418
59Distal lower limb muscle weakness (HP:0009053)2.06767316
60Progressive muscle weakness (HP:0003323)2.06551569
61Segmental peripheral demyelination/remyelination (HP:0003481)2.06218899
62Spontaneous hematomas (HP:0007420)2.06218867
63Distal upper limb amyotrophy (HP:0007149)2.03093944
64Upper limb amyotrophy (HP:0009129)2.03093944
65Hematochezia (HP:0002573)2.00947739
66Fatigue (HP:0012378)2.00916608
67Mitral valve prolapse (HP:0001634)2.00831866
68Amyloidosis (HP:0011034)2.00081952
69Vasculitis (HP:0002633)2.00067433
70Trismus (HP:0000211)1.98891697
71Recurrent gram-negative bacterial infections (HP:0005420)1.98612453
72Aortic aneurysm (HP:0004942)1.95874359
73Rectal prolapse (HP:0002035)1.95805265
74Abnormality of macrophages (HP:0004311)1.95079159
75Bone pain (HP:0002653)1.93941186
76Petechiae (HP:0000967)1.93768427
77Hyperparathyroidism (HP:0000843)1.93540852
78Thick nail (HP:0001805)1.93016767
79Hand muscle atrophy (HP:0009130)1.92643428
80Abnormal blistering of the skin (HP:0008066)1.92256073
81Abnormal trabecular bone morphology (HP:0100671)1.92000608
82Slender build (HP:0001533)1.90786999
83Gastrointestinal infarctions (HP:0005244)1.90052870
84Agammaglobulinemia (HP:0004432)1.89949494
85Increased connective tissue (HP:0009025)1.89544527
86Radial bowing (HP:0002986)1.88392717
87Papilloma (HP:0012740)1.87996432
88Verrucae (HP:0200043)1.87996432
89Abnormality of nail color (HP:0100643)1.85876526
90Gastrointestinal inflammation (HP:0004386)1.85305972
91Increased IgE level (HP:0003212)1.85044849
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.84748258
93Mediastinal lymphadenopathy (HP:0100721)1.84360424
94Flat acetabular roof (HP:0003180)1.84210551
95Onycholysis (HP:0001806)1.83913534
96Thin bony cortex (HP:0002753)1.82913152
97Gastrointestinal dysmotility (HP:0002579)1.82909021
98Chronic obstructive pulmonary disease (HP:0006510)1.82399884
99Obstructive lung disease (HP:0006536)1.82399884
100Aortic dissection (HP:0002647)1.82395512
101Deviation of the thumb (HP:0009603)1.81654454
102Myopathic facies (HP:0002058)1.81543595
103Achilles tendon contracture (HP:0001771)1.80915770
104Progressive neurologic deterioration (HP:0002344)1.80853365
105Myocardial infarction (HP:0001658)1.80778884
106Autoimmune hemolytic anemia (HP:0001890)1.80509836
107Nail dystrophy (HP:0008404)1.80210751
108Chest pain (HP:0100749)1.80145111
109Prolonged neonatal jaundice (HP:0006579)1.80114610
110Impaired platelet aggregation (HP:0003540)1.80027646
111Abnormal platelet function (HP:0011869)1.80027646
112Persistence of primary teeth (HP:0006335)1.79832212
113Selective tooth agenesis (HP:0001592)1.79768726
114Hemorrhage of the eye (HP:0011885)1.79552305
115Vertebral compression fractures (HP:0002953)1.78353814
116Lymphopenia (HP:0001888)1.78336507
117Disproportionate tall stature (HP:0001519)1.78117443
118Bowed forearm bones (HP:0003956)1.78108825
119Bowing of the arm (HP:0006488)1.78108825
120Aneurysm (HP:0002617)1.75455584
121Urinary glycosaminoglycan excretion (HP:0003541)1.75087167
122Mucopolysacchariduria (HP:0008155)1.75087167
123Encephalitis (HP:0002383)1.74775299
124Subacute progressive viral hepatitis (HP:0006572)1.74696484
125Emphysema (HP:0002097)1.74498131
126Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74112061
127Short 4th metacarpal (HP:0010044)1.74112061
128Inflammation of the large intestine (HP:0002037)1.73451167
129Orchitis (HP:0100796)1.70057393
130Skin rash (HP:0000988)1.69986700
131Atrophic scars (HP:0001075)1.69414801
132Abnormal delayed hypersensitivity skin test (HP:0002963)1.69128793
133Periodontitis (HP:0000704)1.68915585
134Increased serum ferritin (HP:0003281)1.68283273
135Optic neuritis (HP:0100653)1.68277480
136Retrobulbar optic neuritis (HP:0100654)1.68277480
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.68274722
138Abnormality of polysaccharide metabolism (HP:0011012)1.68274722
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.68274722
140Gingivitis (HP:0000230)1.68005870
141Disinhibition (HP:0000734)1.65724743
142Hypertriglyceridemia (HP:0002155)1.65345512
143High pitched voice (HP:0001620)1.65120027
144Abdominal distention (HP:0003270)1.65017190
145Urticaria (HP:0001025)1.64913304
146Osteomyelitis (HP:0002754)1.64606944
147Abnormality of the distal phalanges of the toes (HP:0010182)1.64593310
148IgA deficiency (HP:0002720)1.64461965
149Dysostosis multiplex (HP:0000943)1.64113256
150Reticulocytosis (HP:0001923)1.63619661
151Bicuspid aortic valve (HP:0001647)1.63529289
152Arterial thrombosis (HP:0004420)1.63034375
153Abnormality of the Achilles tendon (HP:0005109)1.62614060
154Abnormality of the acetabulum (HP:0003170)1.62278242
155IgM deficiency (HP:0002850)1.62145205
156Frequent falls (HP:0002359)1.61661719
157Bladder diverticulum (HP:0000015)1.60958070
158Blue sclerae (HP:0000592)1.60159630
159Malignant gastrointestinal tract tumors (HP:0006749)1.59523892
160Gastrointestinal carcinoma (HP:0002672)1.59523892
161Proximal placement of thumb (HP:0009623)1.57436113
162Severe short stature (HP:0003510)1.57333905
163Skin ulcer (HP:0200042)1.57245727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.97164239
2PKN23.65772182
3EEF2K3.53928259
4ERN13.25580112
5PRPF4B3.13625401
6MAP3K103.01923323
7SMG12.99853326
8IRAK32.88437768
9CDK122.76949859
10MAP4K12.62297585
11TTN2.38609363
12STK102.27118908
13LRRK22.08357587
14TAOK21.95223966
15RIPK41.93725408
16PTK61.93122397
17IRAK41.80654009
18TESK21.64072107
19GRK61.61583929
20PAK41.54822922
21EPHB11.53051036
22RPS6KA41.52618270
23ARAF1.48929713
24SCYL21.46444551
25TBK11.44982980
26TYK21.40380567
27RIPK11.39911485
28MAP3K141.39832068
29VRK21.38844674
30TESK11.38639694
31NEK21.38625791
32BLK1.36031336
33MAP3K81.26368118
34RPS6KB21.22301563
35CDK61.21725815
36PIM21.20901383
37SIK11.20230269
38ALK1.19794524
39JAK31.14097740
40MAP3K11.10435834
41LMTK21.09542316
42PIM11.06009536
43MAP2K31.05285690
44FLT31.04785522
45KIT1.04017114
46CSK1.04002048
47NME21.03784253
48SIK31.03164329
49BUB11.03078516
50CDK41.02733391
51BTK1.02346130
52ZAP701.01752930
53PDGFRA1.01337888
54EPHA21.01135950
55ICK0.99718469
56CDC70.98158797
57CSF1R0.96449816
58MAP3K110.95965412
59CAMK1D0.95535527
60DMPK0.93579536
61MTOR0.92985153
62STK30.90323487
63KSR20.89739406
64PAK20.88419580
65STK40.83952088
66HCK0.81852569
67PBK0.79850194
68ILK0.79340541
69CDC42BPA0.79120477
70FGFR40.77614057
71CDK70.77002585
72DDR20.74829786
73LIMK10.74668045
74JAK10.74380441
75PTK20.73647350
76MAP3K130.72894332
77BCKDK0.72258851
78PRKD20.70224039
79KDR0.69208891
80PRKG20.67478673
81TAOK10.66559851
82IRAK20.66446063
83FGFR30.65804777
84PDPK10.65312492
85ABL20.65262107
86NEK10.64371172
87TGFBR20.63703696
88MST1R0.60748599
89CHUK0.60622122
90FES0.60161201
91MATK0.59684948
92TRPM70.59576888
93SIK20.57407824
94TGFBR10.56825998
95IKBKE0.56790423
96BRAF0.56770002
97IKBKB0.56403872
98MAPKAPK20.55227680
99MARK30.54360156
100LCK0.54272514
101FGR0.53106070
102STK160.52980921
103PAK10.52156829
104ITK0.51791406
105JAK20.51711238
106LATS10.51177904
107LYN0.51131338
108SYK0.50576465
109DAPK10.49196569
110DYRK1B0.48976551
111RPS6KA60.48386102
112PDGFRB0.47897809
113CLK10.47835124
114MAP3K60.47542813
115CAMK1G0.47503270
116RPS6KC10.46667976
117RPS6KL10.46667976
118MAPK110.46265840
119AURKB0.45986656
120MAPKAPK30.45050128
121HIPK20.44424914
122EGFR0.43798947
123MAP2K20.43206977
124RPS6KA10.41842935
125MAP3K50.41612677
126NEK90.40954513
127RPS6KA20.40044562
128* BMX0.39803648
129DAPK30.39787073
130MET0.39683773
131MAP3K30.39108893
132PDK10.39067666
133AURKA0.38845875
134TTK0.38139949
135MOS0.37734677
136RET0.36321702

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.31240143
2Allograft rejection_Homo sapiens_hsa053301.94938811
3Chronic myeloid leukemia_Homo sapiens_hsa052201.89006699
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.87699147
5Fructose and mannose metabolism_Homo sapiens_hsa000511.78876291
6Graft-versus-host disease_Homo sapiens_hsa053321.73188391
7Osteoclast differentiation_Homo sapiens_hsa043801.72328066
8Autoimmune thyroid disease_Homo sapiens_hsa053201.71587238
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69720251
10Antigen processing and presentation_Homo sapiens_hsa046121.66946034
11B cell receptor signaling pathway_Homo sapiens_hsa046621.63366102
12Shigellosis_Homo sapiens_hsa051311.60685484
13Small cell lung cancer_Homo sapiens_hsa052221.58254843
14Legionellosis_Homo sapiens_hsa051341.56345499
15Toxoplasmosis_Homo sapiens_hsa051451.55793778
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.54820570
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.53996136
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51791492
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.45447787
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42357908
21One carbon pool by folate_Homo sapiens_hsa006701.41487470
22DNA replication_Homo sapiens_hsa030301.40699947
23Viral myocarditis_Homo sapiens_hsa054161.39545540
24Acute myeloid leukemia_Homo sapiens_hsa052211.39138910
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38776754
26Measles_Homo sapiens_hsa051621.38338336
27* Apoptosis_Homo sapiens_hsa042101.37565032
28Sulfur relay system_Homo sapiens_hsa041221.33557239
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.31371887
30Proteoglycans in cancer_Homo sapiens_hsa052051.31085830
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30821727
32Hepatitis B_Homo sapiens_hsa051611.30472316
33Tuberculosis_Homo sapiens_hsa051521.29463736
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28306877
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27039454
36* Viral carcinogenesis_Homo sapiens_hsa052031.26596646
37Bladder cancer_Homo sapiens_hsa052191.26055694
38Malaria_Homo sapiens_hsa051441.25294271
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25101630
40Salmonella infection_Homo sapiens_hsa051321.24469790
41Pancreatic cancer_Homo sapiens_hsa052121.24202830
42Pertussis_Homo sapiens_hsa051331.22177777
43Adherens junction_Homo sapiens_hsa045201.21976524
44Renin-angiotensin system_Homo sapiens_hsa046141.21280768
45Herpes simplex infection_Homo sapiens_hsa051681.19073392
46Sulfur metabolism_Homo sapiens_hsa009201.18475933
47TNF signaling pathway_Homo sapiens_hsa046681.18042277
48Amoebiasis_Homo sapiens_hsa051461.16856707
49p53 signaling pathway_Homo sapiens_hsa041151.15603529
50Focal adhesion_Homo sapiens_hsa045101.15280822
51* MicroRNAs in cancer_Homo sapiens_hsa052061.14363025
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.12530542
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11131624
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.10855881
55Proteasome_Homo sapiens_hsa030501.09627251
56Primary immunodeficiency_Homo sapiens_hsa053401.08746754
57Staphylococcus aureus infection_Homo sapiens_hsa051501.07717928
58Influenza A_Homo sapiens_hsa051641.06558729
59HIF-1 signaling pathway_Homo sapiens_hsa040661.04363897
60HTLV-I infection_Homo sapiens_hsa051661.04085503
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03518813
62Hematopoietic cell lineage_Homo sapiens_hsa046400.99564357
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.99233050
64Caffeine metabolism_Homo sapiens_hsa002320.98244539
65Non-small cell lung cancer_Homo sapiens_hsa052230.97990485
66Cell cycle_Homo sapiens_hsa041100.97148663
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96512919
68VEGF signaling pathway_Homo sapiens_hsa043700.96018463
69Pentose phosphate pathway_Homo sapiens_hsa000300.95147908
70Platelet activation_Homo sapiens_hsa046110.94667211
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.94321798
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93170580
73Type I diabetes mellitus_Homo sapiens_hsa049400.92499519
74Notch signaling pathway_Homo sapiens_hsa043300.92124899
75mTOR signaling pathway_Homo sapiens_hsa041500.91548752
76Rheumatoid arthritis_Homo sapiens_hsa053230.91059444
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90599044
78Phagosome_Homo sapiens_hsa041450.90102298
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89793877
80Colorectal cancer_Homo sapiens_hsa052100.89256105
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.88898741
82Lysosome_Homo sapiens_hsa041420.87970137
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87073939
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86995085
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86343094
86Systemic lupus erythematosus_Homo sapiens_hsa053220.81156712
87Chemokine signaling pathway_Homo sapiens_hsa040620.77560943
88Galactose metabolism_Homo sapiens_hsa000520.76797371
89Hepatitis C_Homo sapiens_hsa051600.76622119
90ECM-receptor interaction_Homo sapiens_hsa045120.75846592
91T cell receptor signaling pathway_Homo sapiens_hsa046600.74985814
92Renal cell carcinoma_Homo sapiens_hsa052110.74946599
93Other glycan degradation_Homo sapiens_hsa005110.74782806
94Epstein-Barr virus infection_Homo sapiens_hsa051690.74096852
95Vibrio cholerae infection_Homo sapiens_hsa051100.72317949
96Thyroid cancer_Homo sapiens_hsa052160.71111727
97Endocytosis_Homo sapiens_hsa041440.70703083
98Folate biosynthesis_Homo sapiens_hsa007900.70668970
99RNA transport_Homo sapiens_hsa030130.70132450
100Mismatch repair_Homo sapiens_hsa034300.70047761
101Base excision repair_Homo sapiens_hsa034100.69873980
102Fat digestion and absorption_Homo sapiens_hsa049750.69825835
103Insulin resistance_Homo sapiens_hsa049310.69606613
104Asthma_Homo sapiens_hsa053100.69382004
105Lysine degradation_Homo sapiens_hsa003100.67581356
106Ribosome_Homo sapiens_hsa030100.67437954
107Carbon metabolism_Homo sapiens_hsa012000.67304112
108Pyrimidine metabolism_Homo sapiens_hsa002400.66529128
109Endometrial cancer_Homo sapiens_hsa052130.66431710
110Prion diseases_Homo sapiens_hsa050200.64951431
111Prostate cancer_Homo sapiens_hsa052150.64182068
112Spliceosome_Homo sapiens_hsa030400.63082240
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62733943
114* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62135582
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.61605771
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60175091
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59590997
118Glioma_Homo sapiens_hsa052140.59061437
119Prolactin signaling pathway_Homo sapiens_hsa049170.57971790
120Glutathione metabolism_Homo sapiens_hsa004800.57214967
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56836416
122Pathways in cancer_Homo sapiens_hsa052000.55909665
123N-Glycan biosynthesis_Homo sapiens_hsa005100.55739517
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.55089491
125Biosynthesis of amino acids_Homo sapiens_hsa012300.51773097
126African trypanosomiasis_Homo sapiens_hsa051430.49240350
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48938441
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48192260
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45977627
130Sphingolipid metabolism_Homo sapiens_hsa006000.45316871

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