BAMBI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.29068150
2Golgi transport vesicle coating (GO:0048200)6.29068150
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.08699622
4cranial suture morphogenesis (GO:0060363)4.59935992
5regulation of sister chromatid cohesion (GO:0007063)4.57712421
6outflow tract septum morphogenesis (GO:0003148)4.30780684
7secondary heart field specification (GO:0003139)4.02350926
8heart field specification (GO:0003128)4.02350926
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.96269342
10negative regulation of catenin import into nucleus (GO:0035414)3.92567429
11endocardial cushion morphogenesis (GO:0003203)3.84784527
12desmosome organization (GO:0002934)3.80581395
13glandular epithelial cell development (GO:0002068)3.79387798
14COPII vesicle coating (GO:0048208)3.78108505
15protein maturation by protein folding (GO:0022417)3.74192321
16type B pancreatic cell development (GO:0003323)3.73842910
17cell surface receptor signaling pathway involved in heart development (GO:0061311)3.72505696
18mesenchyme morphogenesis (GO:0072132)3.71210866
19paraxial mesoderm development (GO:0048339)3.62376837
20cellular protein complex localization (GO:0034629)3.61303806
21regulation of cardioblast differentiation (GO:0051890)3.61150576
22glandular epithelial cell differentiation (GO:0002067)3.59143300
23protein retention in ER lumen (GO:0006621)3.52431318
24cellular response to vitamin D (GO:0071305)3.49520351
25craniofacial suture morphogenesis (GO:0097094)3.41439590
26cardiac myofibril assembly (GO:0055003)3.38938794
27cardiac epithelial to mesenchymal transition (GO:0060317)3.29599221
28columnar/cuboidal epithelial cell development (GO:0002066)3.27571143
29peptide hormone processing (GO:0016486)3.26571573
30exocrine pancreas development (GO:0031017)3.23733902
31regulation of secondary heart field cardioblast proliferation (GO:0003266)3.22836622
32regulation of cardioblast proliferation (GO:0003264)3.22836622
33embryonic skeletal joint morphogenesis (GO:0060272)3.22736122
34signal transduction involved in regulation of gene expression (GO:0023019)3.21916653
35regulation of transforming growth factor beta2 production (GO:0032909)3.20387392
36signal peptide processing (GO:0006465)3.20104023
37protein complex localization (GO:0031503)3.17730607
38retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15875230
39regulation of cell proliferation involved in kidney development (GO:1901722)3.12471554
40uterus development (GO:0060065)3.12259266
41branching involved in mammary gland duct morphogenesis (GO:0060444)3.11347851
42endocardial cushion development (GO:0003197)3.09740943
43gap junction assembly (GO:0016264)3.08421403
44lymph vessel development (GO:0001945)3.08359744
45cardiac right ventricle morphogenesis (GO:0003215)3.06297570
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.04483689
47tooth mineralization (GO:0034505)3.04375204
48positive regulation of hair cycle (GO:0042635)3.03640671
49positive regulation of hair follicle development (GO:0051798)3.03640671
50endocrine pancreas development (GO:0031018)3.02918216
51chondrocyte development (GO:0002063)3.02843895
52regulation of translational fidelity (GO:0006450)3.02704412
53atrial septum morphogenesis (GO:0060413)3.02524334
54pharyngeal system development (GO:0060037)2.98919978
55nuclear pore complex assembly (GO:0051292)2.98783465
56establishment of apical/basal cell polarity (GO:0035089)2.91109942
57proline biosynthetic process (GO:0006561)2.91054869
58vascular endothelial growth factor signaling pathway (GO:0038084)2.89981687
59basement membrane organization (GO:0071711)2.89741579
60mitotic chromosome condensation (GO:0007076)2.89722492
61cardiac muscle tissue morphogenesis (GO:0055008)2.88759258
62receptor catabolic process (GO:0032801)2.88346996
63sarcomere organization (GO:0045214)2.87646270
64anterior/posterior axis specification, embryo (GO:0008595)2.86484414
65regulation of centriole replication (GO:0046599)2.84184797
66heart trabecula formation (GO:0060347)2.83918829
67lung vasculature development (GO:0060426)2.83728624
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83511191
69regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82125080
70regulation of hair follicle development (GO:0051797)2.81492168
71epithelial tube branching involved in lung morphogenesis (GO:0060441)2.79996150
72ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.78967104
73vagina development (GO:0060068)2.75917755
74heart process (GO:0003015)2.73644223
75heart contraction (GO:0060047)2.73644223
76SMAD protein signal transduction (GO:0060395)2.73416190
77atrioventricular valve morphogenesis (GO:0003181)2.72075865
78regulation of establishment of planar polarity (GO:0090175)2.70813450
79nuclear pore organization (GO:0006999)2.70120318
80* regulation of catenin import into nucleus (GO:0035412)2.68979243
81trabecula formation (GO:0060343)2.68929119
82mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.67287824
83cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.65501800
84organ formation (GO:0048645)2.64899754
85myofibril assembly (GO:0030239)2.63990442
86ectodermal placode formation (GO:0060788)2.61498814
87regulation of mesenchymal cell apoptotic process (GO:2001053)2.60389894
88heart valve morphogenesis (GO:0003179)2.59972638
89epithelial cell fate commitment (GO:0072148)2.59552572
90activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.59309494
91trophectodermal cell differentiation (GO:0001829)2.59201515
92branching involved in salivary gland morphogenesis (GO:0060445)2.58679933
93intestinal epithelial cell development (GO:0060576)2.58541334
94bone trabecula formation (GO:0060346)2.58490837
95muscle tissue morphogenesis (GO:0060415)2.56448333
96embryonic camera-type eye morphogenesis (GO:0048596)2.55705173
97nephron tubule morphogenesis (GO:0072078)2.55556088
98nephron epithelium morphogenesis (GO:0072088)2.55556088
99sequestering of metal ion (GO:0051238)2.54877893
100maternal placenta development (GO:0001893)2.54135432
101ventricular cardiac muscle cell development (GO:0055015)2.53678877
102actin-myosin filament sliding (GO:0033275)2.53049031
103muscle filament sliding (GO:0030049)2.53049031
104endothelium development (GO:0003158)2.52928120
105positive regulation of nuclease activity (GO:0032075)2.52291502
106embryonic foregut morphogenesis (GO:0048617)2.52267681
107regulation of heart morphogenesis (GO:2000826)2.51448041
108cardiac muscle cell development (GO:0055013)2.50518439
109adherens junction assembly (GO:0034333)2.50034082
110epithelial cell-cell adhesion (GO:0090136)2.49682136
111positive regulation of hormone biosynthetic process (GO:0046886)2.49355516
112cardiac cell development (GO:0055006)2.48304107
113embryonic eye morphogenesis (GO:0048048)2.48257872
114non-canonical Wnt signaling pathway (GO:0035567)2.47591441
115regulation of SMAD protein import into nucleus (GO:0060390)2.45884863
1164-hydroxyproline metabolic process (GO:0019471)2.45665522
117axis elongation (GO:0003401)2.45410835
118positive regulation of DNA-dependent DNA replication (GO:2000105)2.44676921
119negative regulation of glycoprotein biosynthetic process (GO:0010561)2.43226257
120branching involved in prostate gland morphogenesis (GO:0060442)2.42419268
121negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.41720408
122regulation of keratinocyte proliferation (GO:0010837)2.41276099
123biotin metabolic process (GO:0006768)2.41192336
124actin-mediated cell contraction (GO:0070252)2.40683621
125cell proliferation involved in kidney development (GO:0072111)2.40551926
126ear development (GO:0043583)2.40527464
127cardiac ventricle morphogenesis (GO:0003208)2.40220569
128female genitalia development (GO:0030540)2.39853265
129regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.38160987
130cellular response to vitamin (GO:0071295)2.37880287
131positive regulation of SMAD protein import into nucleus (GO:0060391)2.35845095
132lymphangiogenesis (GO:0001946)2.34910925
133regulation of smooth muscle cell differentiation (GO:0051150)2.34483457
134mesenchymal cell proliferation (GO:0010463)2.34474865
135negative regulation of smooth muscle cell differentiation (GO:0051151)2.34472386
136regulation of mammary gland epithelial cell proliferation (GO:0033599)2.34299566
137positive regulation of transcription regulatory region DNA binding (GO:2000679)2.33676144
138organ induction (GO:0001759)2.33203837
139negative regulation of striated muscle cell apoptotic process (GO:0010664)2.33190109
140cardiac chamber morphogenesis (GO:0003206)2.32865623
141bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31991949
142positive regulation of epidermis development (GO:0045684)2.31788016
143DNA unwinding involved in DNA replication (GO:0006268)2.30803782
144regulation of nuclease activity (GO:0032069)2.30802013
145regulation of cell fate specification (GO:0042659)2.29989459
146actomyosin structure organization (GO:0031032)2.29751312
147negative regulation of stem cell proliferation (GO:2000647)2.29536994
148surfactant homeostasis (GO:0043129)2.28677880
149endothelial cell morphogenesis (GO:0001886)2.27702887
150regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.27228664
151formation of primary germ layer (GO:0001704)2.27137427
152cell migration involved in heart development (GO:0060973)2.26849158
153notochord development (GO:0030903)2.26706972
154low-density lipoprotein particle clearance (GO:0034383)2.26179624
155mesenchymal cell differentiation (GO:0048762)2.25868248
156positive regulation of vasculogenesis (GO:2001214)2.25538235
157vesicle coating (GO:0006901)2.25420249
158specification of organ identity (GO:0010092)2.25238644
159embryonic heart tube development (GO:0035050)2.25005827
160mesenchymal to epithelial transition (GO:0060231)2.24727839
161lung morphogenesis (GO:0060425)2.24718869
162peptide catabolic process (GO:0043171)2.24227653
163cardiac septum morphogenesis (GO:0060411)2.24196282
164mesoderm formation (GO:0001707)2.23707704
165negative regulation of epidermal cell differentiation (GO:0045605)2.22993049
166epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.22219834
167regulation of apoptotic process involved in morphogenesis (GO:1902337)2.21508485
168regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.21494910
169dorsal/ventral axis specification (GO:0009950)2.20084311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.05890460
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.17128385
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.68533354
4ZNF263_19887448_ChIP-Seq_K562_Human3.46593437
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.06383179
6E2F7_22180533_ChIP-Seq_HELA_Human2.99076415
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.83857792
8ESR1_15608294_ChIP-ChIP_MCF-7_Human2.82048671
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79769754
10DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.72961530
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.69184200
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.68279912
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.65789783
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.61131779
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35263816
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35263816
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35263816
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32142968
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26958131
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12476311
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09972791
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99458868
23* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96808970
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.95341364
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94567217
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92445611
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.91233870
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88541926
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88422753
30ELK1_19687146_ChIP-ChIP_HELA_Human1.86350566
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84692524
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.83220177
33GATA1_22025678_ChIP-Seq_K562_Human1.82641357
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78425591
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78263456
36* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76809463
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.75074728
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72264259
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71463282
40* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.70429175
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68445506
42* RACK7_27058665_Chip-Seq_MCF-7_Human1.68014929
43CLOCK_20551151_ChIP-Seq_293T_Human1.66812133
44TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.66078757
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65907528
46* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65506626
47AR_21909140_ChIP-Seq_LNCAP_Human1.65372428
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.64837751
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.63328910
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.61583492
51TTF2_22483619_ChIP-Seq_HELA_Human1.60268349
52KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60034943
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59493800
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59111574
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.55929684
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54325897
57* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53886059
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52657420
59GABP_19822575_ChIP-Seq_HepG2_Human1.52499679
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52429539
61XRN2_22483619_ChIP-Seq_HELA_Human1.50966565
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50682952
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50017325
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.49756256
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47348484
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47094803
67ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46388310
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.46355538
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45340497
70* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45222025
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.44385505
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43590691
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42728659
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42120145
75DCP1A_22483619_ChIP-Seq_HELA_Human1.41748160
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41403607
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41166321
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41137303
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39785443
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39033505
81GATA3_24758297_ChIP-Seq_MCF-7_Human1.37753013
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36374980
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36074178
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.31317873
85* EP300_21415370_ChIP-Seq_HL-1_Mouse1.30139793
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.29040903
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28652217
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.26873970
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25213466
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24949597
91GATA4_21415370_ChIP-Seq_HL-1_Mouse1.24689367
92* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21020562
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20510443
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20122962
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19712970
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19636330
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19312714
98SOX17_20123909_ChIP-Seq_XEN_Mouse1.19058863
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18728384
100CIITA_25753668_ChIP-Seq_RAJI_Human1.14841046
101SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14777753
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14200764
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12944744
104VDR_23849224_ChIP-Seq_CD4+_Human1.12869586
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12753519
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11922192
107* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10992597
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.10432560
109* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10318780
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09522232
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08753287
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08232414
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08162893
114* GATA6_25053715_ChIP-Seq_YYC3_Human1.08037662
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07640931
116* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06792739
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06347871
118NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06302572
119AHR_22903824_ChIP-Seq_MCF-7_Human1.05818876
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05388982
121TBX20_22080862_ChIP-Seq_HEART_Mouse1.03739634
122TBX20_22328084_ChIP-Seq_HEART_Mouse1.03739634
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03405533
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02939672
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02909556
126BRD4_25478319_ChIP-Seq_HGPS_Human1.01291466
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00715355
128SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00469048
129* CHD1_26751641_Chip-Seq_LNCaP_Human1.00412731
130* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00369645
131TFEB_21752829_ChIP-Seq_HELA_Human0.98947651
132ATF3_27146783_Chip-Seq_COLON_Human0.98720595
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.97470124
134ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97155320
135STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97053860
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96797372
137* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96722651
138PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96575569
139* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95583553
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94507312
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93681528
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93312006
143HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92242703
144FOXP3_21729870_ChIP-Seq_TREG_Human0.92077344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.34288514
2MP0003123_paternal_imprinting3.21277015
3MP0002877_abnormal_melanocyte_morpholog3.10679545
4MP0010234_abnormal_vibrissa_follicle3.09060527
5MP0001986_abnormal_taste_sensitivity2.87865108
6MP0010368_abnormal_lymphatic_system2.69782791
7MP0003705_abnormal_hypodermis_morpholog2.65751588
8MP0010030_abnormal_orbit_morphology2.44971837
9MP0004272_abnormal_basement_membrane2.40985161
10MP0003941_abnormal_skin_development2.39058608
11MP0000013_abnormal_adipose_tissue2.36668262
12MP0000678_abnormal_parathyroid_gland2.27885751
13MP0002254_reproductive_system_inflammat2.27253797
14MP0001879_abnormal_lymphatic_vessel2.22190937
15MP0004084_abnormal_cardiac_muscle2.17719054
16MP0003121_genomic_imprinting2.07378129
17MP0006054_spinal_hemorrhage1.97342611
18MP0000537_abnormal_urethra_morphology1.88254996
19MP0009053_abnormal_anal_canal1.87381490
20MP0005408_hypopigmentation1.77463514
21MP0005076_abnormal_cell_differentiation1.72318567
22MP0002796_impaired_skin_barrier1.70910306
23MP0002697_abnormal_eye_size1.70671865
24MP0003119_abnormal_digestive_system1.70668279
25MP0002837_dystrophic_cardiac_calcinosis1.69073714
26MP0000579_abnormal_nail_morphology1.68487417
27MP0005670_abnormal_white_adipose1.68349903
28MP0000534_abnormal_ureter_morphology1.67683777
29MP0003567_abnormal_fetal_cardiomyocyte1.65597512
30MP0002127_abnormal_cardiovascular_syste1.64547528
31MP0003136_yellow_coat_color1.63077962
32MP0005171_absent_coat_pigmentation1.60598079
33MP0008007_abnormal_cellular_replicative1.60151540
34MP0004264_abnormal_extraembryonic_tissu1.56568345
35MP0003283_abnormal_digestive_organ1.52500247
36MP0010678_abnormal_skin_adnexa1.51981145
37MP0001944_abnormal_pancreas_morphology1.49198912
38MP0000566_synostosis1.48392387
39MP0005379_endocrine/exocrine_gland_phen1.48312576
40MP0002098_abnormal_vibrissa_morphology1.47342272
41MP0002938_white_spotting1.44954959
42MP0005503_abnormal_tendon_morphology1.44644307
43MP0002234_abnormal_pharynx_morphology1.44225765
44MP0005257_abnormal_intraocular_pressure1.43146783
45MP0005367_renal/urinary_system_phenotyp1.40388348
46MP0000516_abnormal_urinary_system1.40388348
47MP0002896_abnormal_bone_mineralization1.38799435
48MP0003693_abnormal_embryo_hatching1.38257870
49MP0003828_pulmonary_edema1.37971803
50MP0002092_abnormal_eye_morphology1.37233747
51MP0000383_abnormal_hair_follicle1.36479368
52MP0004215_abnormal_myocardial_fiber1.33737090
53MP0000428_abnormal_craniofacial_morphol1.31891337
54MP0002009_preneoplasia1.30849404
55MP0005220_abnormal_exocrine_pancreas1.30274045
56MP0003935_abnormal_craniofacial_develop1.30094162
57MP0000749_muscle_degeneration1.30088997
58MP0005508_abnormal_skeleton_morphology1.28916507
59MP0002089_abnormal_postnatal_growth/wei1.28818715
60MP0005275_abnormal_skin_tensile1.25570412
61MP0002693_abnormal_pancreas_physiology1.25494337
62MP0000462_abnormal_digestive_system1.25104007
63MP0000613_abnormal_salivary_gland1.24473338
64MP0002249_abnormal_larynx_morphology1.24330625
65MP0003115_abnormal_respiratory_system1.23633012
66MP0009780_abnormal_chondrocyte_physiolo1.23005835
67MP0010352_gastrointestinal_tract_polyps1.21739864
68MP0003315_abnormal_perineum_morphology1.21638325
69MP0000049_abnormal_middle_ear1.21442836
70MP0003077_abnormal_cell_cycle1.21084586
71MP0003385_abnormal_body_wall1.20115419
72MP0005501_abnormal_skin_physiology1.20101028
73MP0000627_abnormal_mammary_gland1.19807831
74MP0003984_embryonic_growth_retardation1.18794964
75MP0002088_abnormal_embryonic_growth/wei1.18552340
76MP0004233_abnormal_muscle_weight1.17967169
77MP0000003_abnormal_adipose_tissue1.17822440
78MP0002972_abnormal_cardiac_muscle1.16048061
79MP0005248_abnormal_Harderian_gland1.15408487
80MP0004036_abnormal_muscle_relaxation1.10177239
81MP0005380_embryogenesis_phenotype1.10009558
82MP0001672_abnormal_embryogenesis/_devel1.10009558
83MP0009384_cardiac_valve_regurgitation1.09350813
84MP0004957_abnormal_blastocyst_morpholog1.09298157
85MP0003942_abnormal_urinary_system1.08991080
86MP0000762_abnormal_tongue_morphology1.08976213
87MP0005197_abnormal_uvea_morphology1.08307585
88MP0000163_abnormal_cartilage_morphology1.06456784
89MP0003890_abnormal_embryonic-extraembry1.06333500
90MP0006072_abnormal_retinal_apoptosis1.05774324
91MP0003937_abnormal_limbs/digits/tail_de1.05592738
92MP0010630_abnormal_cardiac_muscle1.05085657
93MP0003279_aneurysm1.02909653
94MP0006138_congestive_heart_failure1.01822312
95MP0003111_abnormal_nucleus_morphology1.01231039
96MP0002925_abnormal_cardiovascular_devel1.01132438
97MP0002060_abnormal_skin_morphology1.00988065
98MP0002653_abnormal_ependyma_morphology1.00125331
99MP0005409_darkened_coat_color0.99570800
100MP0003453_abnormal_keratinocyte_physiol0.98994341
101MP0009250_abnormal_appendicular_skeleto0.98988608
102MP0000377_abnormal_hair_follicle0.98515133
103MP0000427_abnormal_hair_cycle0.98445502
104MP0001730_embryonic_growth_arrest0.96811648
105MP0002233_abnormal_nose_morphology0.96499771
106MP0003566_abnormal_cell_adhesion0.95836709
107MP0009703_decreased_birth_body0.95007005
108MP0005058_abnormal_lysosome_morphology0.93046156
109MP0003943_abnormal_hepatobiliary_system0.92882238
110MP0001286_abnormal_eye_development0.92645335
111MP0002080_prenatal_lethality0.92569898
112MP0008932_abnormal_embryonic_tissue0.92536663
113MP0003183_abnormal_peptide_metabolism0.92322732
114MP0000266_abnormal_heart_morphology0.92169039
115MP0009840_abnormal_foam_cell0.91694107
116MP0003195_calcinosis0.91439581
117MP0002116_abnormal_craniofacial_bone0.91325886
118MP0001697_abnormal_embryo_size0.91088349
119MP0000350_abnormal_cell_proliferation0.90451082
120MP0004043_abnormal_pH_regulation0.90147171
121MP0002086_abnormal_extraembryonic_tissu0.90132899
122MP0005330_cardiomyopathy0.89640037
123MP0002085_abnormal_embryonic_tissue0.89503101
124MP0003936_abnormal_reproductive_system0.89141083
125MP0002909_abnormal_adrenal_gland0.89037846
126MP0002177_abnormal_outer_ear0.88273283
127MP0005385_cardiovascular_system_phenoty0.87927920
128MP0001544_abnormal_cardiovascular_syste0.87927920
129MP0000750_abnormal_muscle_regeneration0.87221677
130MP0001542_abnormal_bone_strength0.86586740
131MP0002163_abnormal_gland_morphology0.85767619
132MP0000432_abnormal_head_morphology0.85351799
133MP0000467_abnormal_esophagus_morphology0.85115342
134MP0001340_abnormal_eyelid_morphology0.84284368
135MP0001346_abnormal_lacrimal_gland0.84088905
136MP0001293_anophthalmia0.83265728
137MP0010094_abnormal_chromosome_stability0.83018258
138MP0002084_abnormal_developmental_patter0.82918018
139MP0008438_abnormal_cutaneous_collagen0.81960606
140MP0003755_abnormal_palate_morphology0.81100587
141MP0000767_abnormal_smooth_muscle0.81084321
142MP0002111_abnormal_tail_morphology0.79791894
143MP0002932_abnormal_joint_morphology0.79584344
144MP0004782_abnormal_surfactant_physiolog0.78767330
145MP0002109_abnormal_limb_morphology0.77097004
146MP0009672_abnormal_birth_weight0.76936738
147MP0002282_abnormal_trachea_morphology0.76643198
148MP0004381_abnormal_hair_follicle0.75949235
149MP0004185_abnormal_adipocyte_glucose0.73700984

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.25035693
2Abnormal pancreas size (HP:0012094)3.65917731
3Hypoglycemic seizures (HP:0002173)3.57833714
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.52991828
5Hyperglycemia (HP:0003074)3.52864038
6Pancreatic islet-cell hyperplasia (HP:0004510)3.51950149
7Hypoglycemic coma (HP:0001325)3.44172213
8Absent eyebrow (HP:0002223)3.35264881
9Microglossia (HP:0000171)3.30252355
10Symptomatic seizures (HP:0011145)3.30120968
11Asymmetry of the thorax (HP:0001555)3.25052831
12Osteomalacia (HP:0002749)3.23444111
13Insomnia (HP:0100785)3.15026440
14Diaphragmatic weakness (HP:0009113)3.14613900
15Septate vagina (HP:0001153)3.13972428
16Abnormality of the pancreatic islet cells (HP:0006476)3.07817220
17Abnormality of endocrine pancreas physiology (HP:0012093)3.07817220
18J-shaped sella turcica (HP:0002680)2.96629141
19Hepatoblastoma (HP:0002884)2.94760043
20Hypoplastic labia majora (HP:0000059)2.94523788
21Absent eyelashes (HP:0000561)2.85523251
22Uterine leiomyosarcoma (HP:0002891)2.83939024
23Leiomyosarcoma (HP:0100243)2.83939024
24Insulin-resistant diabetes mellitus (HP:0000831)2.77216265
25Aplasia cutis congenita (HP:0001057)2.67310857
26Short middle phalanx of the 5th finger (HP:0004220)2.64861765
27Large for gestational age (HP:0001520)2.62433766
28Ventricular tachycardia (HP:0004756)2.58470835
29Abnormality of the labia majora (HP:0012881)2.57203939
30Abnormality of calcium-phosphate metabolism (HP:0100530)2.56485479
31Abnormality of the distal phalanges of the toes (HP:0010182)2.55940446
32Myelomeningocele (HP:0002475)2.53650520
33Hyperacusis (HP:0010780)2.51270970
34Overriding aorta (HP:0002623)2.50579188
35Late onset (HP:0003584)2.49432795
36Concave nail (HP:0001598)2.48800532
37Decreased circulating renin level (HP:0003351)2.45645832
38Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.45214231
39Bifid tongue (HP:0010297)2.45046899
40Ketoacidosis (HP:0001993)2.44617726
41Patent foramen ovale (HP:0001655)2.43544512
42Premature skin wrinkling (HP:0100678)2.33697839
43Hypoplasia of the fovea (HP:0007750)2.33177319
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.33177319
45Pili torti (HP:0003777)2.31707753
46Gastrointestinal carcinoma (HP:0002672)2.26495034
47Malignant gastrointestinal tract tumors (HP:0006749)2.26495034
48Transitional cell carcinoma of the bladder (HP:0006740)2.25855612
49Ulnar bowing (HP:0003031)2.25261866
50Renal duplication (HP:0000075)2.23366058
51Choanal stenosis (HP:0000452)2.17517379
52Subaortic stenosis (HP:0001682)2.17159726
53Abnormality of the left ventricular outflow tract (HP:0011103)2.17159726
54Facial cleft (HP:0002006)2.16432211
55Short clavicles (HP:0000894)2.14761070
56Protrusio acetabuli (HP:0003179)2.14579593
57Increased nuchal translucency (HP:0010880)2.13620097
58Metaphyseal cupping (HP:0003021)2.13478323
59Broad toe (HP:0001837)2.11902765
60Partial duplication of thumb phalanx (HP:0009944)2.11324624
61Germ cell neoplasia (HP:0100728)2.10919945
62Abnormality of the gastric mucosa (HP:0004295)2.09438599
63Aplasia involving bones of the upper limbs (HP:0009823)2.08001476
64Aplasia of the phalanges of the hand (HP:0009802)2.08001476
65Aplasia involving bones of the extremities (HP:0009825)2.08001476
66Breast carcinoma (HP:0003002)2.05296609
67Abnormality of the fetal cardiovascular system (HP:0010948)2.04868851
68Abnormal umbilical cord blood vessels (HP:0011403)2.04868851
69Single umbilical artery (HP:0001195)2.04868851
70Mesomelia (HP:0003027)2.04284672
71Bladder neoplasm (HP:0009725)2.02100338
72Bladder carcinoma (HP:0002862)2.02100338
73Insidious onset (HP:0003587)2.02037899
74Termporal pattern (HP:0011008)2.02037899
75Abnormalities of placenta or umbilical cord (HP:0001194)2.01984671
76Deviation of the thumb (HP:0009603)2.01250297
77Proximal placement of thumb (HP:0009623)1.99936984
78Partial duplication of the phalanx of hand (HP:0009999)1.99925482
79Abnormal tarsal ossification (HP:0008369)1.97637178
80Elfin facies (HP:0004428)1.96195967
81Abnormality of the fovea (HP:0000493)1.93838440
82Short 5th finger (HP:0009237)1.92979603
83Unilateral renal agenesis (HP:0000122)1.92954781
84Follicular hyperkeratosis (HP:0007502)1.92556110
85Slender long bone (HP:0003100)1.91760019
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.91715032
87Osteolytic defects of the hand bones (HP:0009699)1.91715032
88Bifid scrotum (HP:0000048)1.91416411
89Renovascular hypertension (HP:0100817)1.91198627
90Abnormal ventriculo-arterial connection (HP:0011563)1.90583377
91Transposition of the great arteries (HP:0001669)1.90583377
92Abnormal connection of the cardiac segments (HP:0011545)1.90583377
93Occipital encephalocele (HP:0002085)1.89704758
94Hypopigmentation of the fundus (HP:0007894)1.89334253
95Sudden death (HP:0001699)1.89327652
96Duplication of thumb phalanx (HP:0009942)1.88246162
97Insulin resistance (HP:0000855)1.87736026
98Abnormality of dentin (HP:0010299)1.87690124
99Micronodular cirrhosis (HP:0001413)1.86735278
100Midline defect of the nose (HP:0004122)1.86510095
101Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86344120
102Ankyloglossia (HP:0010296)1.86156976
103Abnormality of the sella turcica (HP:0002679)1.85673228
104Dysautonomia (HP:0002459)1.85597033
105Deformed sella turcica (HP:0002681)1.83370977
106Renal cell carcinoma (HP:0005584)1.82818494
107Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.82430111
108Sparse lateral eyebrow (HP:0005338)1.82328748
109Amelogenesis imperfecta (HP:0000705)1.81680892
110Absent frontal sinuses (HP:0002688)1.80848178
111Premature rupture of membranes (HP:0001788)1.79727749
112Right ventricular cardiomyopathy (HP:0011663)1.79704335
113Ectopic anus (HP:0004397)1.78378841
114Back pain (HP:0003418)1.77806397
115Spinal cord lesions (HP:0100561)1.77664256
116Syringomyelia (HP:0003396)1.77664256
117Broad distal phalanx of finger (HP:0009836)1.77379667
118Lipoatrophy (HP:0100578)1.76629190
119Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75867393
120Prominent metopic ridge (HP:0005487)1.75737721
121Arnold-Chiari malformation (HP:0002308)1.75727205
122Congenital sensorineural hearing impairment (HP:0008527)1.75113159
123Congenital malformation of the right heart (HP:0011723)1.74585997
124Double outlet right ventricle (HP:0001719)1.74585997
125Delayed epiphyseal ossification (HP:0002663)1.74498715
126Uterine neoplasm (HP:0010784)1.74027056
127Cerebral aneurysm (HP:0004944)1.73449338
128Flared iliac wings (HP:0002869)1.73337784
129Hypoplastic left heart (HP:0004383)1.73084640
130Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72842537
131Onycholysis (HP:0001806)1.72503182
132Wide cranial sutures (HP:0010537)1.71684109
133Bicornuate uterus (HP:0000813)1.71240000
134Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70671677
135Abnormality of the metopic suture (HP:0005556)1.70174668
136Flat acetabular roof (HP:0003180)1.70039965
137Hypokalemia (HP:0002900)1.69989489
138Sparse eyelashes (HP:0000653)1.69355666
139Atrial fibrillation (HP:0005110)1.69211071
140Morphological abnormality of the middle ear (HP:0008609)1.68584449
141Intestinal polyposis (HP:0200008)1.68280208
142Abnormality of the lacrimal duct (HP:0011481)1.67763672
143Exercise-induced muscle cramps (HP:0003710)1.67333054
144Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67246986
145Preaxial foot polydactyly (HP:0001841)1.66628022
146Bilateral microphthalmos (HP:0007633)1.66452945
147Dilated cardiomyopathy (HP:0001644)1.66450978
148Nonimmune hydrops fetalis (HP:0001790)1.65659121
149Flat capital femoral epiphysis (HP:0003370)1.65063591
150Spinal rigidity (HP:0003306)1.64878552
151Abnormality of the nasolacrimal system (HP:0000614)1.64505477
152Missing ribs (HP:0000921)1.64338672
153Shallow orbits (HP:0000586)1.63335289
154Abnormality of the salivary glands (HP:0010286)1.63028117
155Anal stenosis (HP:0002025)1.62304490
156Abnormality of the 2nd finger (HP:0004100)1.62084132
157Advanced eruption of teeth (HP:0006288)1.61400815
158Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.60730006
159Hypotrichosis (HP:0001006)1.60685788
160Abnormality of the parietal bone (HP:0002696)1.60630307
161Dysmetric saccades (HP:0000641)1.60589948
162Thoracolumbar scoliosis (HP:0002944)1.60579832
163Abnormal foot bone ossification (HP:0010675)1.60468395
164Lip pit (HP:0100267)1.60416854
165Subacute progressive viral hepatitis (HP:0006572)1.60397242
166Broad long bones (HP:0005622)1.59994678
167Intestinal polyp (HP:0005266)1.59581527
168Median cleft lip (HP:0000161)1.59122447
169Diastasis recti (HP:0001540)1.58163933
170Broad thumb (HP:0011304)1.57443811
171Platyspondyly (HP:0000926)1.56728915
172Mildly elevated creatine phosphokinase (HP:0008180)1.56473278
173Woolly hair (HP:0002224)1.56246481
174Capillary hemangiomas (HP:0005306)1.55326644
175Popliteal pterygium (HP:0009756)1.54932667
176Shawl scrotum (HP:0000049)1.54633075
177Colon cancer (HP:0003003)1.53943916
178Abnormality of the umbilical cord (HP:0010881)1.53261196
179Preauricular pit (HP:0004467)1.53254804
180Periauricular skin pits (HP:0100277)1.53254804
181Generalized aminoaciduria (HP:0002909)1.52493467
182Cervical subluxation (HP:0003308)1.52009290
183Short hallux (HP:0010109)1.51735981
184Skin pits (HP:0100276)1.51210840
185Neoplasm of the adrenal gland (HP:0100631)1.51118711
186Intestinal atresia (HP:0011100)1.50536107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.82508881
2TRIB34.09592904
3MKNK23.50825782
4PASK3.19315713
5KDR3.15666586
6EEF2K3.06780044
7MAP3K32.99829604
8TIE12.74930873
9ZAK2.60704502
10SIK12.44935646
11STK38L2.41609040
12PBK2.40777892
13INSRR2.34271961
14PIK3CG2.33212640
15NME22.18632984
16AKT32.00886688
17MKNK11.95191851
18EPHA21.93834962
19PRKD31.92019982
20MAP3K121.92004124
21OBSCN1.90934892
22FLT31.88795518
23MAP3K21.87485029
24SMG11.85019716
25WNK31.75808935
26FRK1.68148827
27PNCK1.62906936
28BRSK21.62853911
29MYLK1.60974618
30PLK41.57139971
31EIF2AK11.55275834
32STK391.50236988
33EPHB21.47416316
34PDGFRA1.43556875
35LMTK21.42773622
36STK241.40400273
37VRK11.37001043
38ACVR1B1.35628878
39WNK41.34742304
40FER1.32884565
41RIPK11.32320830
42ICK1.32266407
43TESK11.29906485
44DYRK31.28368995
45BUB11.25542871
46HIPK21.23857461
47TGFBR11.23418460
48MAP2K21.19938167
49MUSK1.15625084
50RPS6KA41.13069872
51BRAF1.12892741
52TAOK31.11862873
53FGFR21.10869972
54EPHA31.10562270
55ERN11.07645546
56DMPK1.05011825
57SRPK11.03092819
58CDC42BPA0.99514408
59NLK0.99417554
60EIF2AK30.94643248
61LATS10.91166847
62LATS20.91078177
63WEE10.88942968
64PKN20.86991437
65TYRO30.85011956
66TAF10.82127568
67STK30.79444112
68TTK0.78745065
69AKT20.78695222
70PTK20.78553997
71SCYL20.77998444
72PTK60.77472318
73BRD40.76042546
74CDK70.75044724
75CDK80.74725770
76MAP3K10.74573966
77RET0.73119073
78NEK20.72802494
79FGFR40.72692155
80NEK10.72396846
81TSSK60.70101105
82CDK60.69041321
83IRAK10.68941696
84ERBB40.66772895
85ERBB30.66185103
86LRRK20.64983128
87PLK30.64307807
88IRAK30.64067043
89MAP3K100.63508074
90MAP3K110.62456764
91MST1R0.62402261
92PIK3CA0.61166809
93PRKCI0.59442390
94MST40.59309427
95PAK40.58132561
96AURKB0.58067495
97TRIM280.55150769
98RPS6KB10.54944967
99BRSK10.52910317
100PAK20.52244315
101MAP2K10.51055392
102PLK10.48852164
103TGFBR20.48497773
104CDC70.48453940
105MELK0.48033238
106MET0.47250152
107FGFR10.47150810
108DYRK1B0.47086064
109AURKA0.46619854
110TTN0.46177220
111NEK60.45012401
112MTOR0.44588705
113MAPKAPK30.43111454
114CHEK20.42237545
115RPS6KB20.41768414
116BMPR1B0.41767462
117CSNK1E0.39859985
118KSR20.39427689
119KSR10.39394539
120CHUK0.38399913
121TLK10.38112592
122PDK40.36943550
123PDK30.36943550
124ILK0.34642163
125LIMK10.34597528
126PAK30.34172628
127STK40.34056067
128MAP3K90.33808630
129CDK120.33534517
130MAP2K30.33269770
131DDR20.33137524
132DAPK30.32505394
133ATM0.32429896
134EIF2AK20.31927946
135ATR0.30159851
136NEK90.29961497
137GRK10.29589606
138MAP3K80.28977790
139CHEK10.27928353
140CDK10.27506679
141PDK20.27282298

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.80944227
2Protein export_Homo sapiens_hsa030604.37543239
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.51682147
4Sulfur metabolism_Homo sapiens_hsa009201.97997451
5Cell cycle_Homo sapiens_hsa041101.89890681
6Steroid biosynthesis_Homo sapiens_hsa001001.82778889
7Mismatch repair_Homo sapiens_hsa034301.73163332
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69687092
9DNA replication_Homo sapiens_hsa030301.68271133
10Basal cell carcinoma_Homo sapiens_hsa052171.66328518
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64741156
12RNA transport_Homo sapiens_hsa030131.62948385
13Vitamin B6 metabolism_Homo sapiens_hsa007501.59733086
14Hedgehog signaling pathway_Homo sapiens_hsa043401.59406073
15RNA polymerase_Homo sapiens_hsa030201.59336740
16Spliceosome_Homo sapiens_hsa030401.58826130
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58624400
18Circadian rhythm_Homo sapiens_hsa047101.50789018
19Dilated cardiomyopathy_Homo sapiens_hsa054141.48726378
20Hippo signaling pathway_Homo sapiens_hsa043901.46602621
21ECM-receptor interaction_Homo sapiens_hsa045121.45998638
22Adherens junction_Homo sapiens_hsa045201.45565952
23* TGF-beta signaling pathway_Homo sapiens_hsa043501.40475182
24Folate biosynthesis_Homo sapiens_hsa007901.40223781
25Insulin secretion_Homo sapiens_hsa049111.37923001
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36991837
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35403315
28N-Glycan biosynthesis_Homo sapiens_hsa005101.35363202
29Biosynthesis of amino acids_Homo sapiens_hsa012301.35086639
30Pentose phosphate pathway_Homo sapiens_hsa000301.31205559
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.29822593
32Systemic lupus erythematosus_Homo sapiens_hsa053221.28052530
33RNA degradation_Homo sapiens_hsa030181.27817352
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27092672
35Basal transcription factors_Homo sapiens_hsa030221.26271598
36Proteasome_Homo sapiens_hsa030501.23791170
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22920002
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21499567
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21470184
40Nucleotide excision repair_Homo sapiens_hsa034201.20930226
41Thyroid cancer_Homo sapiens_hsa052161.20292377
42Sulfur relay system_Homo sapiens_hsa041221.20016964
43Alcoholism_Homo sapiens_hsa050341.19624586
44p53 signaling pathway_Homo sapiens_hsa041151.18604899
45Ribosome_Homo sapiens_hsa030101.18308753
46Pyrimidine metabolism_Homo sapiens_hsa002401.16250503
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.15997018
48Carbon metabolism_Homo sapiens_hsa012001.15426180
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15406808
50Bladder cancer_Homo sapiens_hsa052191.13604754
51Colorectal cancer_Homo sapiens_hsa052101.11162743
52Homologous recombination_Homo sapiens_hsa034401.08816473
53Pyruvate metabolism_Homo sapiens_hsa006201.08530316
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04988709
55Selenocompound metabolism_Homo sapiens_hsa004501.01925647
56Base excision repair_Homo sapiens_hsa034101.00156660
57Protein digestion and absorption_Homo sapiens_hsa049740.99964312
58Vibrio cholerae infection_Homo sapiens_hsa051100.99727213
59Galactose metabolism_Homo sapiens_hsa000520.98267178
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97728756
61Focal adhesion_Homo sapiens_hsa045100.97495790
62Regulation of autophagy_Homo sapiens_hsa041400.96086344
63Cardiac muscle contraction_Homo sapiens_hsa042600.95952087
64Glucagon signaling pathway_Homo sapiens_hsa049220.95310699
65Purine metabolism_Homo sapiens_hsa002300.92533218
66Sphingolipid metabolism_Homo sapiens_hsa006000.92316097
67mRNA surveillance pathway_Homo sapiens_hsa030150.91094367
68AMPK signaling pathway_Homo sapiens_hsa041520.90277364
69Fanconi anemia pathway_Homo sapiens_hsa034600.90159875
70HTLV-I infection_Homo sapiens_hsa051660.88760677
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86099530
72Tight junction_Homo sapiens_hsa045300.85835470
73Lysine degradation_Homo sapiens_hsa003100.85301923
74Huntingtons disease_Homo sapiens_hsa050160.85116621
75* Wnt signaling pathway_Homo sapiens_hsa043100.84974006
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84495505
77Arginine biosynthesis_Homo sapiens_hsa002200.83037046
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80379493
79Chronic myeloid leukemia_Homo sapiens_hsa052200.79695170
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.77737317
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77399654
82Other glycan degradation_Homo sapiens_hsa005110.77291024
83MicroRNAs in cancer_Homo sapiens_hsa052060.72761170
84Proteoglycans in cancer_Homo sapiens_hsa052050.72588919
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72177673
86Prion diseases_Homo sapiens_hsa050200.71410503
87Small cell lung cancer_Homo sapiens_hsa052220.70969097
88Arginine and proline metabolism_Homo sapiens_hsa003300.69497032
89Prostate cancer_Homo sapiens_hsa052150.68903106
90Renal cell carcinoma_Homo sapiens_hsa052110.67363698
91Melanogenesis_Homo sapiens_hsa049160.67190555
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65118834
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64930683
94Pathways in cancer_Homo sapiens_hsa052000.64820506
95Tyrosine metabolism_Homo sapiens_hsa003500.63793921
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62920291
97mTOR signaling pathway_Homo sapiens_hsa041500.61169925
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60321710
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60256596
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59932744
101Melanoma_Homo sapiens_hsa052180.59806465
102Phenylalanine metabolism_Homo sapiens_hsa003600.59479317
103Parkinsons disease_Homo sapiens_hsa050120.59333026
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58955653
105ErbB signaling pathway_Homo sapiens_hsa040120.58768975
106One carbon pool by folate_Homo sapiens_hsa006700.58380258
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56868742
108Fructose and mannose metabolism_Homo sapiens_hsa000510.56699776
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55914328
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55473425
111Bile secretion_Homo sapiens_hsa049760.55431047
112Vitamin digestion and absorption_Homo sapiens_hsa049770.54353847
113HIF-1 signaling pathway_Homo sapiens_hsa040660.53972909
114Legionellosis_Homo sapiens_hsa051340.53509758
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.53055247
116Estrogen signaling pathway_Homo sapiens_hsa049150.52980976
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52894879
118Glutathione metabolism_Homo sapiens_hsa004800.52600771
119Oocyte meiosis_Homo sapiens_hsa041140.50641095
120Arachidonic acid metabolism_Homo sapiens_hsa005900.50616860
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50236940
122Insulin resistance_Homo sapiens_hsa049310.49811112
123Fatty acid elongation_Homo sapiens_hsa000620.49233732
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48892973
125Oxidative phosphorylation_Homo sapiens_hsa001900.48264200
126Thyroid hormone synthesis_Homo sapiens_hsa049180.48234340
127Notch signaling pathway_Homo sapiens_hsa043300.47813273
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45337339
129Epstein-Barr virus infection_Homo sapiens_hsa051690.44917815
130Type II diabetes mellitus_Homo sapiens_hsa049300.44609905
131Viral carcinogenesis_Homo sapiens_hsa052030.41575727
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.41307995
133Type I diabetes mellitus_Homo sapiens_hsa049400.40075330
134Endometrial cancer_Homo sapiens_hsa052130.39869625
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39309921
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39195032
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37791932
138Lysosome_Homo sapiens_hsa041420.37389842
139Cocaine addiction_Homo sapiens_hsa050300.36612771
140Insulin signaling pathway_Homo sapiens_hsa049100.35458096
141FoxO signaling pathway_Homo sapiens_hsa040680.34669813

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