BANF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleotide-sugar biosynthetic process (GO:0009226)4.60570954
2face development (GO:0060324)4.53240785
3regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.35178679
4positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.35178679
5pseudouridine synthesis (GO:0001522)4.35061147
6regulation of mitotic spindle checkpoint (GO:1903504)4.33910375
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.33910375
8mesenchymal-epithelial cell signaling (GO:0060638)4.18094865
9regulation of memory T cell differentiation (GO:0043380)4.14313544
10protein heterotetramerization (GO:0051290)4.09949734
11somatic hypermutation of immunoglobulin genes (GO:0016446)4.07760825
12somatic diversification of immune receptors via somatic mutation (GO:0002566)4.07760825
13protein complex biogenesis (GO:0070271)3.97201792
14cytochrome complex assembly (GO:0017004)3.91623419
15transcription elongation from RNA polymerase III promoter (GO:0006385)3.87866766
16termination of RNA polymerase III transcription (GO:0006386)3.87866766
17negative regulation of T-helper cell differentiation (GO:0045623)3.87217165
18negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.87217165
19mitochondrial respiratory chain complex assembly (GO:0033108)3.85241008
20positive regulation of actin filament depolymerization (GO:0030836)3.81616607
21nucleotide transmembrane transport (GO:1901679)3.74895279
22valine metabolic process (GO:0006573)3.74878918
23chaperone-mediated protein transport (GO:0072321)3.74425509
24rRNA catabolic process (GO:0016075)3.67708899
25positive regulation of interleukin-8 secretion (GO:2000484)3.66850727
26pyrimidine-containing compound transmembrane transport (GO:0072531)3.61612664
27centriole replication (GO:0007099)3.61320573
28nucleotide-sugar metabolic process (GO:0009225)3.56041336
29histamine secretion (GO:0001821)3.54833027
30lens fiber cell differentiation (GO:0070306)3.52763872
31RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.51660472
32respiratory chain complex IV assembly (GO:0008535)3.38019238
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35566185
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.35566185
35NADH dehydrogenase complex assembly (GO:0010257)3.35566185
36platelet dense granule organization (GO:0060155)3.30460452
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.20560151
38RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)3.19361996
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17653867
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17653867
41arginine catabolic process (GO:0006527)3.14463457
42inner mitochondrial membrane organization (GO:0007007)3.13660142
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.13311096
44negative regulation of B cell apoptotic process (GO:0002903)3.12187044
45regulation of interleukin-8 secretion (GO:2000482)3.09850087
46natural killer cell activation involved in immune response (GO:0002323)3.08320125
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06366649
48regulation of helicase activity (GO:0051095)3.05642632
49rRNA methylation (GO:0031167)3.04557860
50RNA phosphodiester bond hydrolysis (GO:0090501)3.02675298
51DNA damage response, detection of DNA damage (GO:0042769)3.01023912
52rRNA modification (GO:0000154)3.00698826
53cullin deneddylation (GO:0010388)3.00107810
54regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.98800509
55mitochondrial DNA replication (GO:0006264)2.97540091
56UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95931252
57lactate metabolic process (GO:0006089)2.95918559
58fucose catabolic process (GO:0019317)2.91180919
59L-fucose metabolic process (GO:0042354)2.91180919
60L-fucose catabolic process (GO:0042355)2.91180919
61deoxyribonucleotide biosynthetic process (GO:0009263)2.84765281
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.83929529
63regulation of nuclear cell cycle DNA replication (GO:0033262)2.83437069
64negative regulation of alpha-beta T cell differentiation (GO:0046639)2.83387932
65regulation of MHC class I biosynthetic process (GO:0045343)2.83039411
66establishment of protein localization to mitochondrial membrane (GO:0090151)2.82264604
67histamine transport (GO:0051608)2.81924687
68regulation of hexokinase activity (GO:1903299)2.80741242
69regulation of glucokinase activity (GO:0033131)2.80741242
70protein deneddylation (GO:0000338)2.79644302
71regulation of mitochondrial translation (GO:0070129)2.78432665
72pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.76275615
73positive regulation of protein homodimerization activity (GO:0090073)2.76073350
74pyrimidine nucleotide catabolic process (GO:0006244)2.75140689
75histone mRNA metabolic process (GO:0008334)2.74428944
76response to gravity (GO:0009629)2.74222270
77regulation of T-helper 1 cell differentiation (GO:0045625)2.73759387
78positive regulation of cell size (GO:0045793)2.73758974
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.70959658
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70571850
81branched-chain amino acid catabolic process (GO:0009083)2.68137962
82protein localization to cell surface (GO:0034394)2.58357192
83membrane budding (GO:0006900)2.57931259
84viral mRNA export from host cell nucleus (GO:0046784)2.57811539
85transepithelial transport (GO:0070633)2.57069412
86proteasome assembly (GO:0043248)2.54641685
87dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.52858381
88chromatin remodeling at centromere (GO:0031055)2.51013046
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50713934
90ribonucleoprotein complex disassembly (GO:0032988)2.50501182
91centrosome organization (GO:0051297)2.49837042
92negative regulation of type 2 immune response (GO:0002829)2.49725203
93cellular response to exogenous dsRNA (GO:0071360)2.48689614
94Leydig cell differentiation (GO:0033327)2.47980715
95peptidyl-cysteine modification (GO:0018198)2.47808389
96telomere maintenance via recombination (GO:0000722)2.47697940
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.47538656
98intestinal epithelial cell development (GO:0060576)2.47328985
99ncRNA catabolic process (GO:0034661)2.47120910
100CENP-A containing nucleosome assembly (GO:0034080)2.46893693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26023621
2ELK1_19687146_ChIP-ChIP_HELA_Human3.02679458
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97873783
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.95691068
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.76646239
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68712358
7ZNF274_21170338_ChIP-Seq_K562_Hela2.63340767
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.45160501
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.44971291
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40083652
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28986729
12GATA1_22025678_ChIP-Seq_K562_Human2.14841947
13IGF1R_20145208_ChIP-Seq_DFB_Human2.13436519
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04127116
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.98241840
16GBX2_23144817_ChIP-Seq_PC3_Human1.97870561
17EWS_26573619_Chip-Seq_HEK293_Human1.96656405
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94688647
19P300_19829295_ChIP-Seq_ESCs_Human1.92551052
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90493295
21ER_23166858_ChIP-Seq_MCF-7_Human1.85173654
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81840036
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79501898
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77030480
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.76304700
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.75938904
27FUS_26573619_Chip-Seq_HEK293_Human1.72315828
28VDR_23849224_ChIP-Seq_CD4+_Human1.66732129
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64739862
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.63414066
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61440820
32CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.61051777
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60279688
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60178828
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57607929
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.49678955
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.48245055
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47076943
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.44353135
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42552259
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37208294
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37206138
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32314903
44BRD4_25478319_ChIP-Seq_HGPS_Human1.31045321
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.28858825
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.28583891
47MYC_18940864_ChIP-ChIP_HL60_Human1.27354695
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.26517380
49FOXP3_21729870_ChIP-Seq_TREG_Human1.24203141
50SMAD4_21799915_ChIP-Seq_A2780_Human1.23342149
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23185064
52CBP_20019798_ChIP-Seq_JUKART_Human1.23040847
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23040847
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.22641659
55CJUN_26792858_Chip-Seq_BT549_Human1.22576397
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21334805
57FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20454705
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18269248
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18118670
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17007227
61CDX2_22108803_ChIP-Seq_LS180_Human1.16625185
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16364688
63P53_22387025_ChIP-Seq_ESCs_Mouse1.15047645
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14928362
65NANOG_19829295_ChIP-Seq_ESCs_Human1.14559352
66SOX2_19829295_ChIP-Seq_ESCs_Human1.14559352
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14474498
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.13640049
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13640049
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13303608
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10996888
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10334792
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09845019
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09597174
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09490970
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.09337409
77ELF5_23300383_ChIP-Seq_T47D_Human1.07810824
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07153115
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.05062134
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04939337
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04750216
82TAF15_26573619_Chip-Seq_HEK293_Human1.04735146
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04712562
84VDR_22108803_ChIP-Seq_LS180_Human1.03923448
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03118194
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02408855
87TCF4_22108803_ChIP-Seq_LS180_Human1.02171090
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01814598
89P300_18555785_Chip-Seq_ESCs_Mouse1.01662183
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01163496
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.00381615
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.00215652
93CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98990183
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98292426
95SALL4_22934838_ChIP-ChIP_CD34+_Human0.97685551
96ETV1_20927104_ChIP-Seq_GIST48_Human0.97068648
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96770558
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96534263
99RBPJ_21746931_ChIP-Seq_IB4_Human0.96277072
100GATA4_25053715_ChIP-Seq_YYC3_Human0.96110795

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.60678656
2MP0003806_abnormal_nucleotide_metabolis4.19279325
3MP0003300_gastrointestinal_ulcer3.71072048
4MP0008057_abnormal_DNA_replication2.98710609
5MP0006054_spinal_hemorrhage2.82425947
6MP0010386_abnormal_urinary_bladder2.72488934
7MP0005084_abnormal_gallbladder_morpholo2.68244711
8MP0002876_abnormal_thyroid_physiology2.63995072
9MP0009780_abnormal_chondrocyte_physiolo2.61559727
10MP0003693_abnormal_embryo_hatching2.51352589
11MP0000569_abnormal_digit_pigmentation2.38896976
12MP0000538_abnormal_urinary_bladder2.31718112
13MP0008058_abnormal_DNA_repair2.08273330
14MP0002132_abnormal_respiratory_system2.07539954
15MP0003186_abnormal_redox_activity1.99798026
16MP0004134_abnormal_chest_morphology1.96449642
17MP0003252_abnormal_bile_duct1.95381010
18MP0003718_maternal_effect1.93273571
19MP0002127_abnormal_cardiovascular_syste1.90674260
20MP0002163_abnormal_gland_morphology1.84288280
21MP0005220_abnormal_exocrine_pancreas1.81215255
22MP0003011_delayed_dark_adaptation1.81172680
23MP0008007_abnormal_cellular_replicative1.77953809
24MP0005395_other_phenotype1.67927280
25MP0002938_white_spotting1.63743667
26MP0002160_abnormal_reproductive_system1.55949255
27MP0005023_abnormal_wound_healing1.54529199
28MP0002138_abnormal_hepatobiliary_system1.53368852
29MP0002396_abnormal_hematopoietic_system1.49630633
30MP0003195_calcinosis1.49455005
31MP0010094_abnormal_chromosome_stability1.47972520
32MP0002282_abnormal_trachea_morphology1.47104688
33MP0002837_dystrophic_cardiac_calcinosis1.44494815
34MP0004084_abnormal_cardiac_muscle1.40899950
35MP0002928_abnormal_bile_duct1.34608225
36MP0004019_abnormal_vitamin_homeostasis1.34073756
37MP0002168_other_aberrant_phenotype1.33308207
38MP0000343_altered_response_to1.32285999
39MP0008872_abnormal_physiological_respon1.28149800
40MP0002277_abnormal_respiratory_mucosa1.28144801
41MP0001756_abnormal_urination1.25991229
42MP0003279_aneurysm1.22566814
43MP0004133_heterotaxia1.20557482
44MP0009697_abnormal_copulation1.19207522
45MP0000613_abnormal_salivary_gland1.16205894
46MP0001542_abnormal_bone_strength1.15681921
47MP0001529_abnormal_vocalization1.14730326
48MP0002295_abnormal_pulmonary_circulatio1.14431006
49MP0009250_abnormal_appendicular_skeleto1.10917003
50MP0001485_abnormal_pinna_reflex1.09701557
51MP0003943_abnormal_hepatobiliary_system1.09317246
52MP0004957_abnormal_blastocyst_morpholog1.09256945
53MP0001243_abnormal_dermal_layer1.06854625
54MP0005174_abnormal_tail_pigmentation1.02407036
55MP0004215_abnormal_myocardial_fiber1.00644672
56MP0005389_reproductive_system_phenotype0.99738022
57MP0005379_endocrine/exocrine_gland_phen0.99390220
58MP0005166_decreased_susceptibility_to0.96151667
59MP0002254_reproductive_system_inflammat0.94893112
60MP0003137_abnormal_impulse_conducting0.94809237
61MP0000013_abnormal_adipose_tissue0.94495867
62MP0006036_abnormal_mitochondrial_physio0.94264540
63MP0002405_respiratory_system_inflammati0.90838357
64MP0009764_decreased_sensitivity_to0.89770469
65MP0001879_abnormal_lymphatic_vessel0.89689054
66MP0002735_abnormal_chemical_nociception0.87756132
67MP0000762_abnormal_tongue_morphology0.87232980
68MP0004272_abnormal_basement_membrane0.86790393
69MP0002148_abnormal_hypersensitivity_rea0.86319967
70MP0003786_premature_aging0.85086092
71MP0002060_abnormal_skin_morphology0.81724367
72MP0000516_abnormal_urinary_system0.79724533
73MP0005367_renal/urinary_system_phenotyp0.79724533
74MP0002233_abnormal_nose_morphology0.77867592
75MP0010368_abnormal_lymphatic_system0.77676236
76MP0003448_altered_tumor_morphology0.77428399
77MP0003937_abnormal_limbs/digits/tail_de0.77171767
78MP0002736_abnormal_nociception_after0.76401405
79MP0009053_abnormal_anal_canal0.75324945
80MP0003866_abnormal_defecation0.75107462
81MP0005332_abnormal_amino_acid0.74129680
82MP0001984_abnormal_olfaction0.73478098
83MP0000427_abnormal_hair_cycle0.72644132
84MP0003077_abnormal_cell_cycle0.70898511
85MP0006082_CNS_inflammation0.70248475
86MP0005266_abnormal_metabolism0.69605681
87MP0008789_abnormal_olfactory_epithelium0.68837473
88MP0008877_abnormal_DNA_methylation0.68720922
89MP0001666_abnormal_nutrient_absorption0.65254710
90MP0001764_abnormal_homeostasis0.65208396
91MP0002109_abnormal_limb_morphology0.65048054
92MP0010030_abnormal_orbit_morphology0.64293745
93MP0003936_abnormal_reproductive_system0.63936482
94MP0001270_distended_abdomen0.63646901
95MP0010678_abnormal_skin_adnexa0.63608184
96MP0000383_abnormal_hair_follicle0.63607977
97MP0006035_abnormal_mitochondrial_morpho0.63074551
98MP0001177_atelectasis0.62082029
99MP0004142_abnormal_muscle_tone0.61948917
100MP0000653_abnormal_sex_gland0.61398451

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)5.12618807
2Sensory axonal neuropathy (HP:0003390)4.29489837
3Aplastic anemia (HP:0001915)4.07344753
4Spastic paraparesis (HP:0002313)3.63861967
5Spondylolisthesis (HP:0003302)3.49074999
6Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.48569707
7Stillbirth (HP:0003826)3.44326655
8Abnormal tarsal ossification (HP:0008369)3.30343046
9Abnormal foot bone ossification (HP:0010675)3.17475972
10Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.14721750
11Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.09710746
12Depressed nasal tip (HP:0000437)3.06084875
13Aplasia/Hypoplasia of the scapulae (HP:0006713)2.99311684
14Hypoplastic scapulae (HP:0000882)2.99311684
15Bifid tongue (HP:0010297)2.98387916
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93837536
17Abnormality of placental membranes (HP:0011409)2.88420408
18Amniotic constriction ring (HP:0009775)2.88420408
19Popliteal pterygium (HP:0009756)2.86756494
20Abnormality of the phalanges of the 5th finger (HP:0004213)2.83473851
21Increased number of teeth (HP:0011069)2.83317253
22Severe visual impairment (HP:0001141)2.69637260
23Chromsome breakage (HP:0040012)2.68986921
24Increased hepatocellular lipid droplets (HP:0006565)2.65281539
25Methylmalonic acidemia (HP:0002912)2.63747712
26Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.63364632
27Short 5th finger (HP:0009237)2.61587257
28Lipid accumulation in hepatocytes (HP:0006561)2.57557522
29Hepatocellular necrosis (HP:0001404)2.57536304
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.49266002
31Mitochondrial inheritance (HP:0001427)2.42296499
32Type II lissencephaly (HP:0007260)2.41025113
33Congenital, generalized hypertrichosis (HP:0004540)2.40415460
34Microvesicular hepatic steatosis (HP:0001414)2.40045039
35Colon cancer (HP:0003003)2.39761680
36Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.39664111
37Neonatal respiratory distress (HP:0002643)2.38798043
38Increased CSF lactate (HP:0002490)2.35889612
39Tubulointerstitial nephritis (HP:0001970)2.33785157
40Type 2 muscle fiber atrophy (HP:0003554)2.29566111
41Cerebral hypomyelination (HP:0006808)2.27861108
42Abnormality of the pons (HP:0007361)2.26331073
43Microretrognathia (HP:0000308)2.24214747
44Type I transferrin isoform profile (HP:0003642)2.23033373
45Stenosis of the external auditory canal (HP:0000402)2.22624811
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.20130000
47Medulloblastoma (HP:0002885)2.18881184
48Acute necrotizing encephalopathy (HP:0006965)2.18663856
49Metaphyseal dysplasia (HP:0100255)2.17548015
50Renal Fanconi syndrome (HP:0001994)2.05691654
51Progressive macrocephaly (HP:0004481)2.05177061
52Hypoplasia of the pons (HP:0012110)2.04802246
53Methylmalonic aciduria (HP:0012120)2.03655077
54Syringomyelia (HP:0003396)2.03293236
55Spinal cord lesions (HP:0100561)2.03293236
56Abnormality of the frontal sinuses (HP:0002687)2.01548676
57Cupped ribs (HP:0000887)2.01496694
58Hypoplastic iliac wings (HP:0002866)2.00289837
59Abnormality of the ileum (HP:0001549)2.00000882
60Meckel diverticulum (HP:0002245)1.97471694
61Abnormal protein glycosylation (HP:0012346)1.97007355
62Abnormal glycosylation (HP:0012345)1.97007355
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97007355
64Abnormal protein N-linked glycosylation (HP:0012347)1.97007355
65Hepatic necrosis (HP:0002605)1.94849269
66Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.91072630
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91007054
68Respiratory difficulties (HP:0002880)1.90706948
69Molar tooth sign on MRI (HP:0002419)1.90520805
70Abnormality of midbrain morphology (HP:0002418)1.90520805
71Sloping forehead (HP:0000340)1.89800681
72Birth length less than 3rd percentile (HP:0003561)1.89240566
73Acute myeloid leukemia (HP:0004808)1.88664084
74Cerebral edema (HP:0002181)1.88566541
75Ependymoma (HP:0002888)1.88378771
76Median cleft lip (HP:0000161)1.86394565
77Abnormality of the preputium (HP:0100587)1.85844060
78Sparse eyelashes (HP:0000653)1.85267782
79Cerebellar dysplasia (HP:0007033)1.84965991
80Duplicated collecting system (HP:0000081)1.84600685
81Absent frontal sinuses (HP:0002688)1.84214981
82Muscle fiber atrophy (HP:0100295)1.84070803
83Short middle phalanx of finger (HP:0005819)1.82527824
84Small intestinal stenosis (HP:0012848)1.81350750
85Duodenal stenosis (HP:0100867)1.81350750
86Poor head control (HP:0002421)1.80380345
87Supernumerary spleens (HP:0009799)1.79931391
88Clubbing of toes (HP:0100760)1.79592381
89Barrel-shaped chest (HP:0001552)1.79409227
90Volvulus (HP:0002580)1.78645376
91Abnormality of pyrimidine metabolism (HP:0004353)1.78188380
92Abnormal lung lobation (HP:0002101)1.77061681
93Medial flaring of the eyebrow (HP:0010747)1.76899470
94Abnormality of the renal collecting system (HP:0004742)1.76892477
95Hypochromic microcytic anemia (HP:0004840)1.74874424
96Abnormality of the duodenum (HP:0002246)1.73944253
97Abnormality of DNA repair (HP:0003254)1.73520977
98Hypoproteinemia (HP:0003075)1.73385193
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.73184401
100Irregular vertebral endplates (HP:0003301)1.73108998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.44295632
2MAP4K23.35650310
3FRK3.31946914
4STK392.98718736
5SIK32.95169196
6TAF12.89111476
7MAP3K122.83624045
8LMTK22.82250824
9MST42.80044085
10EIF2AK32.59826016
11VRK22.55102462
12BCR2.36318542
13STK162.33197864
14PIK3CA2.22300754
15SRPK12.17041099
16FLT31.87588772
17OXSR11.83861442
18GRK11.81540447
19PBK1.66045805
20MYLK1.64306780
21MKNK11.59571354
22ZAK1.57830421
23MAP3K31.56816106
24TNIK1.56205224
25TAOK31.55651568
26NUAK11.53397628
27BRSK21.50350518
28NME11.49782295
29MKNK21.45296894
30PLK31.36776632
31PIM21.17591728
32STK381.15347394
33STK38L1.12435269
34TEC1.11380571
35DAPK11.07931477
36CDK191.07656512
37LIMK11.01265037
38STK31.01236427
39PAK30.99015675
40KIT0.94928540
41EIF2AK10.86108219
42STK40.84764358
43PIK3CG0.83513884
44WNK40.83023212
45EPHA20.82005773
46FER0.81917576
47BMPR1B0.72932276
48BRD40.71557651
49NLK0.71283381
50PRKCE0.70436595
51DAPK20.68645560
52STK100.68566313
53BCKDK0.68431926
54AKT30.68023678
55PLK10.67961808
56RPS6KA40.66561665
57NEK10.65046407
58CSNK1G10.63305155
59VRK10.62517244
60PRKD30.60897389
61PRKD20.56871937
62PDK20.56636300
63BUB10.55049136
64CSNK2A20.52759290
65PRKCI0.50871777
66CSNK1G20.50568047
67CSNK1G30.49699497
68WNK30.49384103
69RAF10.49337422
70PLK20.47214798
71MUSK0.45211900
72GRK70.45104863
73PRKD10.45006211
74MINK10.44190086
75CSNK1A1L0.44112899
76TSSK60.43965683
77CSNK2A10.41946689
78PNCK0.40840964
79GSK3A0.40334664
80PAK20.40227198
81ABL10.37553634
82DAPK30.36409236
83DYRK20.35685855
84ILK0.33512933
85KSR10.33064531
86DYRK30.33004285
87MAPKAPK50.32852975
88CSNK1A10.32306967
89ERBB30.32169251
90DYRK1A0.31547847
91PAK40.30583903
92PRKCQ0.30563014
93PRKG20.29584324
94CAMK10.29308409
95CSNK1E0.28487343
96DDR20.28081507
97NEK60.27769031
98CASK0.27718430
99ADRBK10.27547554
100BRSK10.27194970

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.58411900
2RNA polymerase_Homo sapiens_hsa030203.52502100
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41455813
4Protein export_Homo sapiens_hsa030603.38699235
5Vitamin B6 metabolism_Homo sapiens_hsa007503.35830163
6Mismatch repair_Homo sapiens_hsa034303.09790501
7DNA replication_Homo sapiens_hsa030302.48860106
8Non-homologous end-joining_Homo sapiens_hsa034502.30580426
9Homologous recombination_Homo sapiens_hsa034402.10173086
10Fanconi anemia pathway_Homo sapiens_hsa034602.06337619
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02878010
12Steroid biosynthesis_Homo sapiens_hsa001002.01638179
13Butanoate metabolism_Homo sapiens_hsa006501.95336562
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94513165
15Pyrimidine metabolism_Homo sapiens_hsa002401.85895434
16Oxidative phosphorylation_Homo sapiens_hsa001901.84586922
17Glutathione metabolism_Homo sapiens_hsa004801.83779446
18Propanoate metabolism_Homo sapiens_hsa006401.83770199
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77151018
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.73679797
21One carbon pool by folate_Homo sapiens_hsa006701.71565798
22RNA degradation_Homo sapiens_hsa030181.69203595
23Basal transcription factors_Homo sapiens_hsa030221.68524469
24Folate biosynthesis_Homo sapiens_hsa007901.65630619
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.56363197
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56145266
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54057828
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51014871
29Parkinsons disease_Homo sapiens_hsa050121.50375593
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46501604
31Ribosome_Homo sapiens_hsa030101.44655412
32Sulfur metabolism_Homo sapiens_hsa009201.43580928
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42170266
34Nucleotide excision repair_Homo sapiens_hsa034201.41342246
35RNA transport_Homo sapiens_hsa030131.36808966
36Selenocompound metabolism_Homo sapiens_hsa004501.30166740
37Purine metabolism_Homo sapiens_hsa002301.27914998
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25237212
39Base excision repair_Homo sapiens_hsa034101.23364015
40Huntingtons disease_Homo sapiens_hsa050161.17220253
41Sulfur relay system_Homo sapiens_hsa041221.09710822
42Peroxisome_Homo sapiens_hsa041461.08324297
43Phototransduction_Homo sapiens_hsa047440.97345358
44p53 signaling pathway_Homo sapiens_hsa041150.94713421
45Alzheimers disease_Homo sapiens_hsa050100.89485566
46beta-Alanine metabolism_Homo sapiens_hsa004100.88938215
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83906753
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80087865
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79131331
50Melanoma_Homo sapiens_hsa052180.78703092
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70966999
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70845917
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69752767
54Olfactory transduction_Homo sapiens_hsa047400.69084821
55TGF-beta signaling pathway_Homo sapiens_hsa043500.68927395
56Metabolic pathways_Homo sapiens_hsa011000.67158174
57Cell cycle_Homo sapiens_hsa041100.64854231
58Tight junction_Homo sapiens_hsa045300.64470976
59Spliceosome_Homo sapiens_hsa030400.62746740
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61853600
61Chemical carcinogenesis_Homo sapiens_hsa052040.61720167
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61120143
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60475733
64Oocyte meiosis_Homo sapiens_hsa041140.58120525
65Fatty acid degradation_Homo sapiens_hsa000710.57963801
66Fatty acid elongation_Homo sapiens_hsa000620.57244664
67Ether lipid metabolism_Homo sapiens_hsa005650.56943339
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54729276
69Pyruvate metabolism_Homo sapiens_hsa006200.53855420
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53679796
71Vitamin digestion and absorption_Homo sapiens_hsa049770.53109164
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51014821
73Arachidonic acid metabolism_Homo sapiens_hsa005900.44884262
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43208616
75Retinol metabolism_Homo sapiens_hsa008300.42590161
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42207569
77Cardiac muscle contraction_Homo sapiens_hsa042600.40603289
78Renin-angiotensin system_Homo sapiens_hsa046140.40590802
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39933364
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38057038
81Caffeine metabolism_Homo sapiens_hsa002320.35010191
82ECM-receptor interaction_Homo sapiens_hsa045120.34456088
83Mineral absorption_Homo sapiens_hsa049780.32194209
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31282703
85Other glycan degradation_Homo sapiens_hsa005110.31139197
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30628629
87N-Glycan biosynthesis_Homo sapiens_hsa005100.29222734
88Wnt signaling pathway_Homo sapiens_hsa043100.27702957
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27626093
90Sphingolipid metabolism_Homo sapiens_hsa006000.25414242
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.24402525
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24213927
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24076092
94Taste transduction_Homo sapiens_hsa047420.23762949
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23343723
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22111102
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22047945
98Linoleic acid metabolism_Homo sapiens_hsa005910.21565958
99mRNA surveillance pathway_Homo sapiens_hsa030150.21513288
100Hedgehog signaling pathway_Homo sapiens_hsa043400.20141394

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