

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.53573752 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.85185040 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.39040355 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 5.39040355 |
| 5 | proteasome assembly (GO:0043248) | 4.94000587 |
| 6 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.89004262 |
| 7 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.65681698 |
| 8 | cytidine metabolic process (GO:0046087) | 4.52831758 |
| 9 | cytidine catabolic process (GO:0006216) | 4.52831758 |
| 10 | cytidine deamination (GO:0009972) | 4.52831758 |
| 11 | protein complex biogenesis (GO:0070271) | 4.52216088 |
| 12 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.38153898 |
| 13 | cullin deneddylation (GO:0010388) | 4.37307538 |
| 14 | respiratory electron transport chain (GO:0022904) | 4.29140656 |
| 15 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.28577338 |
| 16 | electron transport chain (GO:0022900) | 4.25278172 |
| 17 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.22581813 |
| 18 | protein neddylation (GO:0045116) | 4.22081312 |
| 19 | protein deneddylation (GO:0000338) | 4.17861806 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.15487400 |
| 21 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.10336533 |
| 22 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.00884268 |
| 23 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.00884268 |
| 24 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.00884268 |
| 25 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.98081030 |
| 26 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.98081030 |
| 27 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.92049154 |
| 28 | cytochrome complex assembly (GO:0017004) | 3.89666881 |
| 29 | respiratory chain complex IV assembly (GO:0008535) | 3.88993797 |
| 30 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.81847888 |
| 31 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.81680621 |
| 32 | negative regulation of ligase activity (GO:0051352) | 3.81680621 |
| 33 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.80996732 |
| 34 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.80996732 |
| 35 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.80936331 |
| 36 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.80007120 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.74734113 |
| 38 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.64593196 |
| 39 | NADH dehydrogenase complex assembly (GO:0010257) | 3.64593196 |
| 40 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.64593196 |
| 41 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.64111019 |
| 42 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.63799729 |
| 43 | chaperone-mediated protein transport (GO:0072321) | 3.57674165 |
| 44 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.55295065 |
| 45 | protein-cofactor linkage (GO:0018065) | 3.45447759 |
| 46 | purine deoxyribonucleoside triphosphate metabolic process (GO:0009215) | 3.39916837 |
| 47 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.34949921 |
| 48 | GMP metabolic process (GO:0046037) | 3.32806654 |
| 49 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.32566173 |
| 50 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.32509252 |
| 51 | rRNA modification (GO:0000154) | 3.28828239 |
| 52 | DNA ligation (GO:0006266) | 3.26478737 |
| 53 | metallo-sulfur cluster assembly (GO:0031163) | 3.22916950 |
| 54 | iron-sulfur cluster assembly (GO:0016226) | 3.22916950 |
| 55 | sequestering of actin monomers (GO:0042989) | 3.17563530 |
| 56 | positive regulation of ligase activity (GO:0051351) | 3.16296733 |
| 57 | inner mitochondrial membrane organization (GO:0007007) | 3.15741589 |
| 58 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.11808504 |
| 59 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.09814480 |
| 60 | positive regulation of cell cycle arrest (GO:0071158) | 3.03340468 |
| 61 | hydrogen ion transmembrane transport (GO:1902600) | 2.98589935 |
| 62 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.97541682 |
| 63 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.97541682 |
| 64 | regulation of cellular amine metabolic process (GO:0033238) | 2.96887044 |
| 65 | ATP biosynthetic process (GO:0006754) | 2.94776045 |
| 66 | DNA damage response, detection of DNA damage (GO:0042769) | 2.93132472 |
| 67 | mannosylation (GO:0097502) | 2.92329737 |
| 68 | regulation of mitochondrial translation (GO:0070129) | 2.91916642 |
| 69 | termination of RNA polymerase III transcription (GO:0006386) | 2.91191532 |
| 70 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.91191532 |
| 71 | pseudouridine synthesis (GO:0001522) | 2.90570911 |
| 72 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.85220778 |
| 73 | ribosomal small subunit assembly (GO:0000028) | 2.83486560 |
| 74 | piRNA metabolic process (GO:0034587) | 2.83077824 |
| 75 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.80811205 |
| 76 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.80438485 |
| 77 | mismatch repair (GO:0006298) | 2.80250966 |
| 78 | proton transport (GO:0015992) | 2.79965772 |
| 79 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.77087546 |
| 80 | hydrogen transport (GO:0006818) | 2.76506858 |
| 81 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.76282243 |
| 82 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.76106922 |
| 83 | DNA double-strand break processing (GO:0000729) | 2.74551884 |
| 84 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 2.73440439 |
| 85 | establishment of protein localization to mitochondrion (GO:0072655) | 2.73260590 |
| 86 | protein targeting to mitochondrion (GO:0006626) | 2.73128864 |
| 87 | DNA demethylation (GO:0080111) | 2.72422580 |
| 88 | establishment of integrated proviral latency (GO:0075713) | 2.69757613 |
| 89 | platelet dense granule organization (GO:0060155) | 2.67859945 |
| 90 | regulation of ligase activity (GO:0051340) | 2.65889128 |
| 91 | branched-chain amino acid catabolic process (GO:0009083) | 2.63864557 |
| 92 | translation (GO:0006412) | 2.63472483 |
| 93 | maturation of 5.8S rRNA (GO:0000460) | 2.60473124 |
| 94 | intracellular protein transmembrane import (GO:0044743) | 2.59753354 |
| 95 | signal transduction in response to DNA damage (GO:0042770) | 2.56771337 |
| 96 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.56734494 |
| 97 | cotranslational protein targeting to membrane (GO:0006613) | 2.56428982 |
| 98 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.56235249 |
| 99 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.56143984 |
| 100 | regulation of chronic inflammatory response (GO:0002676) | 2.55708394 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.18105996 |
| 2 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.52470434 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.40012130 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.00032534 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.54441941 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.38133828 |
| 7 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.28427076 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.19405823 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.88266214 |
| 10 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.87949318 |
| 11 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.83338071 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.83319042 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.70454103 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.65627569 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.61527724 |
| 16 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.43797179 |
| 17 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.36993741 |
| 18 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.32841659 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.22284240 |
| 20 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.21890093 |
| 21 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.20504429 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.19478293 |
| 23 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.11935897 |
| 24 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.99631443 |
| 25 | VDR_22108803_ChIP-Seq_LS180_Human | 1.99467164 |
| 26 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.88477683 |
| 27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.79339299 |
| 28 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.78278508 |
| 29 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.68979048 |
| 30 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.64649970 |
| 31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.61587817 |
| 32 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.54986774 |
| 33 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.52794963 |
| 34 | EWS_26573619_Chip-Seq_HEK293_Human | 1.52641742 |
| 35 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47421617 |
| 36 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.46925529 |
| 37 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.44667249 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.43803335 |
| 39 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.43322491 |
| 40 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.42116207 |
| 41 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.41640971 |
| 42 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.39647558 |
| 43 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.36734539 |
| 44 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.34333709 |
| 45 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.32697064 |
| 46 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.32597797 |
| 47 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.31268681 |
| 48 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.30887190 |
| 49 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.30774757 |
| 50 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.30500409 |
| 51 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28981156 |
| 52 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.24122267 |
| 53 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.22912369 |
| 54 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.18747804 |
| 55 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.18475180 |
| 56 | FUS_26573619_Chip-Seq_HEK293_Human | 1.17913278 |
| 57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.16939590 |
| 58 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.16939590 |
| 59 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.16391753 |
| 60 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.14300015 |
| 61 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.14040285 |
| 62 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.13561919 |
| 63 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.12867370 |
| 64 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.09737975 |
| 65 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.09729760 |
| 66 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.08189019 |
| 67 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.07654949 |
| 68 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.06764435 |
| 69 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.05425104 |
| 70 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.05237326 |
| 71 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.05159952 |
| 72 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.04801801 |
| 73 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.03540093 |
| 74 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.02230203 |
| 75 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.01889247 |
| 76 | NCOR_22424771_ChIP-Seq_293T_Human | 1.01751648 |
| 77 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.01624134 |
| 78 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.00875406 |
| 79 | GATA3_26560356_Chip-Seq_TH2_Human | 1.00494954 |
| 80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.99973264 |
| 81 | P300_19829295_ChIP-Seq_ESCs_Human | 0.98205999 |
| 82 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.97523256 |
| 83 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.95327812 |
| 84 | AR_20517297_ChIP-Seq_VCAP_Human | 0.94777531 |
| 85 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.91777483 |
| 86 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 0.91731022 |
| 87 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.90776599 |
| 88 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.90268456 |
| 89 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.90223446 |
| 90 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.86724515 |
| 91 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.84613239 |
| 92 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.83057064 |
| 93 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.83057064 |
| 94 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.82309423 |
| 95 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.82025980 |
| 96 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.81858120 |
| 97 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.81601610 |
| 98 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.80531363 |
| 99 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.80074205 |
| 100 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.78971632 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.15522024 |
| 2 | MP0005671_abnormal_response_to | 3.09360723 |
| 3 | MP0006072_abnormal_retinal_apoptosis | 2.81465260 |
| 4 | MP0005645_abnormal_hypothalamus_physiol | 2.73293331 |
| 5 | MP0002102_abnormal_ear_morphology | 2.70999339 |
| 6 | MP0003787_abnormal_imprinting | 2.51153589 |
| 7 | MP0004147_increased_porphyrin_level | 2.41435954 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 2.34073388 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.21954645 |
| 10 | MP0000372_irregular_coat_pigmentation | 2.12607767 |
| 11 | MP0003718_maternal_effect | 2.12562411 |
| 12 | MP0001835_abnormal_antigen_presentation | 1.90202064 |
| 13 | MP0010094_abnormal_chromosome_stability | 1.87353925 |
| 14 | MP0003121_genomic_imprinting | 1.86218057 |
| 15 | MP0003786_premature_aging | 1.84774299 |
| 16 | MP0003806_abnormal_nucleotide_metabolis | 1.83658380 |
| 17 | MP0003283_abnormal_digestive_organ | 1.82959238 |
| 18 | MP0001529_abnormal_vocalization | 1.81120309 |
| 19 | MP0002277_abnormal_respiratory_mucosa | 1.80485229 |
| 20 | MP0002736_abnormal_nociception_after | 1.78662585 |
| 21 | MP0008872_abnormal_physiological_respon | 1.76334190 |
| 22 | MP0003693_abnormal_embryo_hatching | 1.74507258 |
| 23 | MP0005084_abnormal_gallbladder_morpholo | 1.74299607 |
| 24 | MP0008995_early_reproductive_senescence | 1.73296758 |
| 25 | MP0003136_yellow_coat_color | 1.73100547 |
| 26 | MP0001905_abnormal_dopamine_level | 1.70235252 |
| 27 | MP0005646_abnormal_pituitary_gland | 1.63093691 |
| 28 | MP0001968_abnormal_touch/_nociception | 1.60803989 |
| 29 | MP0005253_abnormal_eye_physiology | 1.55941524 |
| 30 | MP0004145_abnormal_muscle_electrophysio | 1.55023160 |
| 31 | MP0003195_calcinosis | 1.54406515 |
| 32 | MP0004142_abnormal_muscle_tone | 1.53703894 |
| 33 | MP0005551_abnormal_eye_electrophysiolog | 1.52088014 |
| 34 | MP0002837_dystrophic_cardiac_calcinosis | 1.51687699 |
| 35 | MP0003011_delayed_dark_adaptation | 1.51425497 |
| 36 | MP0006036_abnormal_mitochondrial_physio | 1.48778843 |
| 37 | MP0009046_muscle_twitch | 1.48482598 |
| 38 | MP0003122_maternal_imprinting | 1.48328833 |
| 39 | MP0006292_abnormal_olfactory_placode | 1.45990107 |
| 40 | MP0001984_abnormal_olfaction | 1.45534050 |
| 41 | MP0002148_abnormal_hypersensitivity_rea | 1.43988924 |
| 42 | MP0006276_abnormal_autonomic_nervous | 1.41815865 |
| 43 | MP0003763_abnormal_thymus_physiology | 1.37641953 |
| 44 | MP0006035_abnormal_mitochondrial_morpho | 1.32030069 |
| 45 | MP0009785_altered_susceptibility_to | 1.31241372 |
| 46 | MP0002653_abnormal_ependyma_morphology | 1.30076124 |
| 47 | MP0005075_abnormal_melanosome_morpholog | 1.29985634 |
| 48 | MP0001800_abnormal_humoral_immune | 1.29881194 |
| 49 | MP0003186_abnormal_redox_activity | 1.23379975 |
| 50 | MP0003880_abnormal_central_pattern | 1.23260844 |
| 51 | MP0001873_stomach_inflammation | 1.22650370 |
| 52 | MP0002876_abnormal_thyroid_physiology | 1.21215011 |
| 53 | MP0001790_abnormal_immune_system | 1.20930016 |
| 54 | MP0005387_immune_system_phenotype | 1.20930016 |
| 55 | MP0001485_abnormal_pinna_reflex | 1.12874769 |
| 56 | MP0009333_abnormal_splenocyte_physiolog | 1.06573445 |
| 57 | MP0005410_abnormal_fertilization | 1.05722590 |
| 58 | MP0005000_abnormal_immune_tolerance | 1.04886087 |
| 59 | MP0009745_abnormal_behavioral_response | 1.04439251 |
| 60 | MP0000631_abnormal_neuroendocrine_gland | 1.01595964 |
| 61 | MP0002751_abnormal_autonomic_nervous | 0.99759673 |
| 62 | MP0002006_tumorigenesis | 0.99425319 |
| 63 | MP0002272_abnormal_nervous_system | 0.98331857 |
| 64 | MP0001764_abnormal_homeostasis | 0.97998908 |
| 65 | MP0002723_abnormal_immune_serum | 0.97428267 |
| 66 | MP0002420_abnormal_adaptive_immunity | 0.95963224 |
| 67 | MP0002163_abnormal_gland_morphology | 0.95563214 |
| 68 | MP0002282_abnormal_trachea_morphology | 0.95354637 |
| 69 | MP0004957_abnormal_blastocyst_morpholog | 0.94133084 |
| 70 | MP0005636_abnormal_mineral_homeostasis | 0.93360697 |
| 71 | MP0001929_abnormal_gametogenesis | 0.92979816 |
| 72 | MP0002166_altered_tumor_susceptibility | 0.92515432 |
| 73 | MP0001819_abnormal_immune_cell | 0.92009672 |
| 74 | MP0006082_CNS_inflammation | 0.88550184 |
| 75 | MP0003077_abnormal_cell_cycle | 0.88325598 |
| 76 | MP0000685_abnormal_immune_system | 0.86590016 |
| 77 | MP0004133_heterotaxia | 0.85994165 |
| 78 | MP0002638_abnormal_pupillary_reflex | 0.85570960 |
| 79 | MP0002452_abnormal_antigen_presenting | 0.84835247 |
| 80 | MP0005389_reproductive_system_phenotype | 0.84831083 |
| 81 | MP0005377_hearing/vestibular/ear_phenot | 0.83345146 |
| 82 | MP0003878_abnormal_ear_physiology | 0.83345146 |
| 83 | MP0002160_abnormal_reproductive_system | 0.82597035 |
| 84 | MP0003866_abnormal_defecation | 0.80500127 |
| 85 | MP0004742_abnormal_vestibular_system | 0.79283162 |
| 86 | MP0000716_abnormal_immune_system | 0.77698196 |
| 87 | MP0001486_abnormal_startle_reflex | 0.75686136 |
| 88 | MP0002822_catalepsy | 0.75517605 |
| 89 | MP0000689_abnormal_spleen_morphology | 0.74776594 |
| 90 | MP0009764_decreased_sensitivity_to | 0.74539900 |
| 91 | MP0000639_abnormal_adrenal_gland | 0.74415085 |
| 92 | MP0000653_abnormal_sex_gland | 0.73980205 |
| 93 | MP0002210_abnormal_sex_determination | 0.73923106 |
| 94 | MP0001986_abnormal_taste_sensitivity | 0.73659799 |
| 95 | MP0001145_abnormal_male_reproductive | 0.72510389 |
| 96 | MP0002132_abnormal_respiratory_system | 0.72086247 |
| 97 | MP0002138_abnormal_hepatobiliary_system | 0.71828929 |
| 98 | MP0008007_abnormal_cellular_replicative | 0.70954437 |
| 99 | MP0002398_abnormal_bone_marrow | 0.70850829 |
| 100 | MP0002557_abnormal_social/conspecific_i | 0.70640561 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.67069377 |
| 2 | Mitochondrial inheritance (HP:0001427) | 4.56525366 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.43428601 |
| 4 | Increased CSF lactate (HP:0002490) | 4.11344110 |
| 5 | Hepatocellular necrosis (HP:0001404) | 4.10948291 |
| 6 | Increased hepatocellular lipid droplets (HP:0006565) | 4.06669271 |
| 7 | Acute encephalopathy (HP:0006846) | 4.04525508 |
| 8 | Aplastic anemia (HP:0001915) | 4.01080351 |
| 9 | Hepatic necrosis (HP:0002605) | 3.91549219 |
| 10 | Progressive macrocephaly (HP:0004481) | 3.89409364 |
| 11 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.60717680 |
| 12 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.60717680 |
| 13 | Increased intramyocellular lipid droplets (HP:0012240) | 3.56825127 |
| 14 | Lipid accumulation in hepatocytes (HP:0006561) | 3.56174035 |
| 15 | 3-Methylglutaconic aciduria (HP:0003535) | 3.38210756 |
| 16 | Cerebral edema (HP:0002181) | 3.28145221 |
| 17 | Renal Fanconi syndrome (HP:0001994) | 3.25516800 |
| 18 | Type II lissencephaly (HP:0007260) | 3.07821199 |
| 19 | Pancreatic cysts (HP:0001737) | 2.90074127 |
| 20 | Increased serum lactate (HP:0002151) | 2.89304019 |
| 21 | Lactic acidosis (HP:0003128) | 2.85805018 |
| 22 | Increased muscle lipid content (HP:0009058) | 2.80212706 |
| 23 | IgG deficiency (HP:0004315) | 2.73679202 |
| 24 | Abolished electroretinogram (ERG) (HP:0000550) | 2.73566500 |
| 25 | Exertional dyspnea (HP:0002875) | 2.71528042 |
| 26 | Optic disc pallor (HP:0000543) | 2.67953800 |
| 27 | True hermaphroditism (HP:0010459) | 2.64985576 |
| 28 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.62907478 |
| 29 | Generalized aminoaciduria (HP:0002909) | 2.62366166 |
| 30 | Type I transferrin isoform profile (HP:0003642) | 2.61490591 |
| 31 | Degeneration of anterior horn cells (HP:0002398) | 2.59880055 |
| 32 | Abnormality of the anterior horn cell (HP:0006802) | 2.59880055 |
| 33 | Abnormal number of erythroid precursors (HP:0012131) | 2.56057203 |
| 34 | Pancreatic fibrosis (HP:0100732) | 2.50456119 |
| 35 | Respiratory failure (HP:0002878) | 2.47625092 |
| 36 | Colon cancer (HP:0003003) | 2.47185285 |
| 37 | Methylmalonic acidemia (HP:0002912) | 2.42897760 |
| 38 | Severe combined immunodeficiency (HP:0004430) | 2.42831616 |
| 39 | Nephronophthisis (HP:0000090) | 2.40207148 |
| 40 | Molar tooth sign on MRI (HP:0002419) | 2.36671129 |
| 41 | Abnormality of midbrain morphology (HP:0002418) | 2.36671129 |
| 42 | Pancytopenia (HP:0001876) | 2.34333074 |
| 43 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.33810929 |
| 44 | Renal cortical cysts (HP:0000803) | 2.32940469 |
| 45 | Glycosuria (HP:0003076) | 2.32465159 |
| 46 | Abnormality of urine glucose concentration (HP:0011016) | 2.32465159 |
| 47 | Abnormality of the renal cortex (HP:0011035) | 2.31151364 |
| 48 | Exercise intolerance (HP:0003546) | 2.30736342 |
| 49 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.30699458 |
| 50 | Methylmalonic aciduria (HP:0012120) | 2.28638646 |
| 51 | Lethargy (HP:0001254) | 2.28015623 |
| 52 | Abnormal protein glycosylation (HP:0012346) | 2.27558512 |
| 53 | Abnormal glycosylation (HP:0012345) | 2.27558512 |
| 54 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.27558512 |
| 55 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.27558512 |
| 56 | Increased IgM level (HP:0003496) | 2.21463924 |
| 57 | Respiratory difficulties (HP:0002880) | 2.19528944 |
| 58 | Congenital, generalized hypertrichosis (HP:0004540) | 2.18641220 |
| 59 | Reduced antithrombin III activity (HP:0001976) | 2.15964505 |
| 60 | Congenital stationary night blindness (HP:0007642) | 2.15785952 |
| 61 | Attenuation of retinal blood vessels (HP:0007843) | 2.15210752 |
| 62 | Hypoproteinemia (HP:0003075) | 2.10610291 |
| 63 | Abnormality of the renal medulla (HP:0100957) | 2.10204535 |
| 64 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.09508982 |
| 65 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.08693881 |
| 66 | Cerebellar dysplasia (HP:0007033) | 2.07975320 |
| 67 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.02476866 |
| 68 | IgM deficiency (HP:0002850) | 2.00817812 |
| 69 | Leukodystrophy (HP:0002415) | 1.98640323 |
| 70 | Bile duct proliferation (HP:0001408) | 1.98299438 |
| 71 | Abnormal biliary tract physiology (HP:0012439) | 1.98299438 |
| 72 | Hyperglycinemia (HP:0002154) | 1.95303947 |
| 73 | Abnormality of renal resorption (HP:0011038) | 1.93706708 |
| 74 | Retinal dysplasia (HP:0007973) | 1.93701742 |
| 75 | Stomatitis (HP:0010280) | 1.92615589 |
| 76 | Hypothermia (HP:0002045) | 1.91263447 |
| 77 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.90416366 |
| 78 | Hypoplasia of the pons (HP:0012110) | 1.90300185 |
| 79 | Pendular nystagmus (HP:0012043) | 1.90255743 |
| 80 | Medial flaring of the eyebrow (HP:0010747) | 1.90149288 |
| 81 | Microvesicular hepatic steatosis (HP:0001414) | 1.89728632 |
| 82 | CNS demyelination (HP:0007305) | 1.89655878 |
| 83 | Abnormality of B cell number (HP:0010975) | 1.89605670 |
| 84 | Large for gestational age (HP:0001520) | 1.89001201 |
| 85 | Ketosis (HP:0001946) | 1.87288307 |
| 86 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.85636078 |
| 87 | Abnormality of the labia minora (HP:0012880) | 1.84187233 |
| 88 | Combined immunodeficiency (HP:0005387) | 1.83800631 |
| 89 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.83364875 |
| 90 | Dicarboxylic aciduria (HP:0003215) | 1.83364875 |
| 91 | Decreased central vision (HP:0007663) | 1.82416763 |
| 92 | Abnormality of alanine metabolism (HP:0010916) | 1.81319518 |
| 93 | Hyperalaninemia (HP:0003348) | 1.81319518 |
| 94 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.81319518 |
| 95 | Abnormality of the pons (HP:0007361) | 1.79487464 |
| 96 | Abnormality of the prostate (HP:0008775) | 1.78064909 |
| 97 | Thyroiditis (HP:0100646) | 1.72198449 |
| 98 | Constricted visual fields (HP:0001133) | 1.71318205 |
| 99 | Agammaglobulinemia (HP:0004432) | 1.71165097 |
| 100 | Abnormality of T cell number (HP:0011839) | 1.69411348 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.52571108 |
| 2 | ZAK | 3.64301668 |
| 3 | TLK1 | 3.46273278 |
| 4 | VRK1 | 3.39630473 |
| 5 | BCKDK | 3.07583411 |
| 6 | BUB1 | 2.46212958 |
| 7 | NUAK1 | 2.45345869 |
| 8 | TESK2 | 2.23416060 |
| 9 | TXK | 2.21859459 |
| 10 | TAOK3 | 2.17063406 |
| 11 | MST4 | 2.14793803 |
| 12 | KDR | 2.09483079 |
| 13 | TSSK6 | 2.08689031 |
| 14 | MAP4K2 | 2.08398514 |
| 15 | ADRBK2 | 1.91059676 |
| 16 | BRSK2 | 1.64772332 |
| 17 | MAP3K12 | 1.61058404 |
| 18 | EIF2AK3 | 1.45178502 |
| 19 | PLK3 | 1.38338162 |
| 20 | GRK1 | 1.32559029 |
| 21 | NME1 | 1.28910401 |
| 22 | GRK7 | 1.26466122 |
| 23 | TRIM28 | 1.22036162 |
| 24 | CSNK1G1 | 1.13874364 |
| 25 | BCR | 1.12865301 |
| 26 | RPS6KA5 | 1.11156144 |
| 27 | CSNK1G3 | 1.09661020 |
| 28 | SRPK1 | 1.08907601 |
| 29 | FRK | 1.05990192 |
| 30 | WNK3 | 1.04609074 |
| 31 | PINK1 | 1.00978050 |
| 32 | OXSR1 | 1.00612540 |
| 33 | MAPKAPK5 | 0.97343067 |
| 34 | NEK1 | 0.96466812 |
| 35 | DYRK2 | 0.93374593 |
| 36 | KIT | 0.92759702 |
| 37 | TEC | 0.91910095 |
| 38 | ITK | 0.88895361 |
| 39 | CSNK1A1L | 0.87293869 |
| 40 | CSNK1G2 | 0.87191268 |
| 41 | MKNK1 | 0.86827086 |
| 42 | PASK | 0.84771173 |
| 43 | IKBKB | 0.83277776 |
| 44 | MAP4K1 | 0.81087432 |
| 45 | WEE1 | 0.80385661 |
| 46 | WNK4 | 0.80025271 |
| 47 | LIMK1 | 0.79609678 |
| 48 | PRKCQ | 0.79465182 |
| 49 | SYK | 0.77548050 |
| 50 | EIF2AK1 | 0.77087875 |
| 51 | BRSK1 | 0.74846589 |
| 52 | INSRR | 0.74283586 |
| 53 | CCNB1 | 0.73791503 |
| 54 | FES | 0.72346834 |
| 55 | TESK1 | 0.71417259 |
| 56 | CDC7 | 0.69322996 |
| 57 | DAPK1 | 0.69208608 |
| 58 | ATR | 0.68948604 |
| 59 | BMPR1B | 0.67518788 |
| 60 | MUSK | 0.65877845 |
| 61 | MAPK13 | 0.64332710 |
| 62 | PLK2 | 0.63712054 |
| 63 | PBK | 0.61761813 |
| 64 | PLK1 | 0.61453807 |
| 65 | TIE1 | 0.60189883 |
| 66 | TAF1 | 0.60092701 |
| 67 | PIK3CA | 0.59678530 |
| 68 | AURKB | 0.59542355 |
| 69 | MYLK | 0.59379523 |
| 70 | STK39 | 0.57941688 |
| 71 | MAPK15 | 0.57210298 |
| 72 | PKN1 | 0.56042339 |
| 73 | TNK2 | 0.55516139 |
| 74 | MKNK2 | 0.55393597 |
| 75 | ADRBK1 | 0.54929012 |
| 76 | PHKG1 | 0.54102067 |
| 77 | PHKG2 | 0.54102067 |
| 78 | PLK4 | 0.53526191 |
| 79 | NLK | 0.52918253 |
| 80 | PIM2 | 0.52818455 |
| 81 | MAPKAPK3 | 0.51601115 |
| 82 | CSNK2A1 | 0.50916586 |
| 83 | STK16 | 0.49825993 |
| 84 | TTK | 0.47933534 |
| 85 | BTK | 0.46457890 |
| 86 | PRKCG | 0.46262172 |
| 87 | AURKA | 0.45521201 |
| 88 | FLT3 | 0.45449485 |
| 89 | CSF1R | 0.44013437 |
| 90 | LYN | 0.43721056 |
| 91 | ARAF | 0.42775692 |
| 92 | CHEK2 | 0.42201836 |
| 93 | CDK8 | 0.42148920 |
| 94 | CSNK2A2 | 0.41432824 |
| 95 | GRK5 | 0.41282242 |
| 96 | TNIK | 0.41175890 |
| 97 | DAPK3 | 0.39627655 |
| 98 | PNCK | 0.39008051 |
| 99 | CSNK1A1 | 0.38213595 |
| 100 | MAP2K7 | 0.35714804 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.76139184 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.93484721 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.36256226 |
| 4 | Protein export_Homo sapiens_hsa03060 | 3.03860191 |
| 5 | Ribosome_Homo sapiens_hsa03010 | 2.78829176 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.52481973 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.49207662 |
| 8 | Allograft rejection_Homo sapiens_hsa05330 | 2.29919072 |
| 9 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.29025817 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.15329216 |
| 11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.11627512 |
| 12 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.05654121 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.05070874 |
| 14 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.99659652 |
| 15 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.85942690 |
| 16 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.82120088 |
| 17 | Mismatch repair_Homo sapiens_hsa03430 | 1.77252072 |
| 18 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.73906554 |
| 19 | DNA replication_Homo sapiens_hsa03030 | 1.71164592 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.59919402 |
| 21 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.56022082 |
| 22 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.55529794 |
| 23 | Phototransduction_Homo sapiens_hsa04744 | 1.54306783 |
| 24 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.51484880 |
| 25 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.45157080 |
| 26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.42375610 |
| 27 | RNA degradation_Homo sapiens_hsa03018 | 1.40396742 |
| 28 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.38404165 |
| 29 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.37274348 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.35087892 |
| 31 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.34990420 |
| 32 | Base excision repair_Homo sapiens_hsa03410 | 1.33721006 |
| 33 | Spliceosome_Homo sapiens_hsa03040 | 1.31073115 |
| 34 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.28792773 |
| 35 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.27948865 |
| 36 | Basal transcription factors_Homo sapiens_hsa03022 | 1.27493274 |
| 37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.24489427 |
| 38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.19691845 |
| 39 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.17622507 |
| 40 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 1.13092889 |
| 41 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.12995449 |
| 42 | Purine metabolism_Homo sapiens_hsa00230 | 1.10856263 |
| 43 | Peroxisome_Homo sapiens_hsa04146 | 1.07653359 |
| 44 | RNA transport_Homo sapiens_hsa03013 | 0.98149165 |
| 45 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.98017102 |
| 46 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.97468888 |
| 47 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.91412758 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.90430406 |
| 49 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.90304531 |
| 50 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.89274523 |
| 51 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.89117975 |
| 52 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.84280778 |
| 53 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.78951021 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.77932127 |
| 55 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.76398356 |
| 56 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.76358881 |
| 57 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.74856203 |
| 58 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.70780745 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.68677767 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.67588976 |
| 61 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.67083037 |
| 62 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.66758888 |
| 63 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.66084511 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60034716 |
| 65 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.59992837 |
| 66 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.56663432 |
| 67 | Alcoholism_Homo sapiens_hsa05034 | 0.55762908 |
| 68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.53604506 |
| 69 | Viral myocarditis_Homo sapiens_hsa05416 | 0.52862647 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52118355 |
| 71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.49741577 |
| 72 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.49610310 |
| 73 | Retinol metabolism_Homo sapiens_hsa00830 | 0.48872567 |
| 74 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.48659426 |
| 75 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48438214 |
| 76 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.47783990 |
| 77 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.46757160 |
| 78 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.46711954 |
| 79 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.45759008 |
| 80 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.43890639 |
| 81 | Olfactory transduction_Homo sapiens_hsa04740 | 0.43523740 |
| 82 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.40106310 |
| 83 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.39581651 |
| 84 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.38803756 |
| 85 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.38477194 |
| 86 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.37141577 |
| 87 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.34705038 |
| 88 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.33895361 |
| 89 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.33483379 |
| 90 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.28691126 |
| 91 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.27489148 |
| 92 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.25769837 |
| 93 | Carbon metabolism_Homo sapiens_hsa01200 | 0.25139897 |
| 94 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.23950037 |
| 95 | Leishmaniasis_Homo sapiens_hsa05140 | 0.19999686 |
| 96 | Sulfur relay system_Homo sapiens_hsa04122 | 0.19439721 |
| 97 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.19157779 |
| 98 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.17664402 |
| 99 | Cell cycle_Homo sapiens_hsa04110 | 0.17179319 |
| 100 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.16967699 |

