BANF1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.53573752
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.85185040
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.39040355
4ATP synthesis coupled proton transport (GO:0015986)5.39040355
5proteasome assembly (GO:0043248)4.94000587
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.89004262
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.65681698
8cytidine metabolic process (GO:0046087)4.52831758
9cytidine catabolic process (GO:0006216)4.52831758
10cytidine deamination (GO:0009972)4.52831758
11protein complex biogenesis (GO:0070271)4.52216088
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.38153898
13cullin deneddylation (GO:0010388)4.37307538
14respiratory electron transport chain (GO:0022904)4.29140656
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.28577338
16electron transport chain (GO:0022900)4.25278172
17mitochondrial respiratory chain complex assembly (GO:0033108)4.22581813
18protein neddylation (GO:0045116)4.22081312
19protein deneddylation (GO:0000338)4.17861806
20regulation of cellular amino acid metabolic process (GO:0006521)4.15487400
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.10336533
22signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.00884268
23signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.00884268
24signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.00884268
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.98081030
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.98081030
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.92049154
28cytochrome complex assembly (GO:0017004)3.89666881
29respiratory chain complex IV assembly (GO:0008535)3.88993797
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.81847888
31negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.81680621
32negative regulation of ligase activity (GO:0051352)3.81680621
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.80996732
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.80996732
35pyrimidine ribonucleoside catabolic process (GO:0046133)3.80936331
36signal transduction involved in cell cycle checkpoint (GO:0072395)3.80007120
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.74734113
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.64593196
39NADH dehydrogenase complex assembly (GO:0010257)3.64593196
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64593196
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.64111019
42water-soluble vitamin biosynthetic process (GO:0042364)3.63799729
43chaperone-mediated protein transport (GO:0072321)3.57674165
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55295065
45protein-cofactor linkage (GO:0018065)3.45447759
46purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.39916837
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.34949921
48GMP metabolic process (GO:0046037)3.32806654
49deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.32566173
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32509252
51rRNA modification (GO:0000154)3.28828239
52DNA ligation (GO:0006266)3.26478737
53metallo-sulfur cluster assembly (GO:0031163)3.22916950
54iron-sulfur cluster assembly (GO:0016226)3.22916950
55sequestering of actin monomers (GO:0042989)3.17563530
56positive regulation of ligase activity (GO:0051351)3.16296733
57inner mitochondrial membrane organization (GO:0007007)3.15741589
58DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.11808504
59antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09814480
60positive regulation of cell cycle arrest (GO:0071158)3.03340468
61hydrogen ion transmembrane transport (GO:1902600)2.98589935
62tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97541682
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97541682
64regulation of cellular amine metabolic process (GO:0033238)2.96887044
65ATP biosynthetic process (GO:0006754)2.94776045
66DNA damage response, detection of DNA damage (GO:0042769)2.93132472
67mannosylation (GO:0097502)2.92329737
68regulation of mitochondrial translation (GO:0070129)2.91916642
69termination of RNA polymerase III transcription (GO:0006386)2.91191532
70transcription elongation from RNA polymerase III promoter (GO:0006385)2.91191532
71pseudouridine synthesis (GO:0001522)2.90570911
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85220778
73ribosomal small subunit assembly (GO:0000028)2.83486560
74piRNA metabolic process (GO:0034587)2.83077824
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80811205
76DNA catabolic process, exonucleolytic (GO:0000738)2.80438485
77mismatch repair (GO:0006298)2.80250966
78proton transport (GO:0015992)2.79965772
79regulation of ubiquitin-protein transferase activity (GO:0051438)2.77087546
80hydrogen transport (GO:0006818)2.76506858
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76282243
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.76106922
83DNA double-strand break processing (GO:0000729)2.74551884
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73440439
85establishment of protein localization to mitochondrion (GO:0072655)2.73260590
86protein targeting to mitochondrion (GO:0006626)2.73128864
87DNA demethylation (GO:0080111)2.72422580
88establishment of integrated proviral latency (GO:0075713)2.69757613
89platelet dense granule organization (GO:0060155)2.67859945
90regulation of ligase activity (GO:0051340)2.65889128
91branched-chain amino acid catabolic process (GO:0009083)2.63864557
92translation (GO:0006412)2.63472483
93maturation of 5.8S rRNA (GO:0000460)2.60473124
94intracellular protein transmembrane import (GO:0044743)2.59753354
95signal transduction in response to DNA damage (GO:0042770)2.56771337
96purine deoxyribonucleotide metabolic process (GO:0009151)2.56734494
97cotranslational protein targeting to membrane (GO:0006613)2.56428982
98SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56235249
99antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.56143984
100regulation of chronic inflammatory response (GO:0002676)2.55708394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.18105996
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.52470434
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.40012130
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.00032534
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.54441941
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38133828
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.28427076
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.19405823
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.88266214
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87949318
11VDR_23849224_ChIP-Seq_CD4+_Human2.83338071
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.83319042
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70454103
14ELK1_19687146_ChIP-ChIP_HELA_Human2.65627569
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61527724
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43797179
17FOXP3_21729870_ChIP-Seq_TREG_Human2.36993741
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32841659
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.22284240
20ZNF274_21170338_ChIP-Seq_K562_Hela2.21890093
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.20504429
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19478293
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11935897
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.99631443
25VDR_22108803_ChIP-Seq_LS180_Human1.99467164
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88477683
27MYC_18940864_ChIP-ChIP_HL60_Human1.79339299
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78278508
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68979048
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64649970
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.61587817
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.54986774
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52794963
34EWS_26573619_Chip-Seq_HEK293_Human1.52641742
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47421617
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.46925529
37DCP1A_22483619_ChIP-Seq_HELA_Human1.44667249
38GABP_19822575_ChIP-Seq_HepG2_Human1.43803335
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.43322491
40TP53_22573176_ChIP-Seq_HFKS_Human1.42116207
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41640971
42IGF1R_20145208_ChIP-Seq_DFB_Human1.39647558
43TTF2_22483619_ChIP-Seq_HELA_Human1.36734539
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34333709
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32697064
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32597797
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31268681
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30887190
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30774757
50EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30500409
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28981156
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.24122267
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22912369
54HTT_18923047_ChIP-ChIP_STHdh_Human1.18747804
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18475180
56FUS_26573619_Chip-Seq_HEK293_Human1.17913278
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16939590
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.16939590
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.16391753
60XRN2_22483619_ChIP-Seq_HELA_Human1.14300015
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14040285
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13561919
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12867370
64IRF1_19129219_ChIP-ChIP_H3396_Human1.09737975
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09729760
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08189019
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07654949
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06764435
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05425104
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05237326
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05159952
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04801801
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03540093
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02230203
75CIITA_25753668_ChIP-Seq_RAJI_Human1.01889247
76NCOR_22424771_ChIP-Seq_293T_Human1.01751648
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01624134
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00875406
79GATA3_26560356_Chip-Seq_TH2_Human1.00494954
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99973264
81P300_19829295_ChIP-Seq_ESCs_Human0.98205999
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97523256
83ERG_20517297_ChIP-Seq_VCAP_Human0.95327812
84AR_20517297_ChIP-Seq_VCAP_Human0.94777531
85MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91777483
86IRF8_21731497_ChIP-ChIP_J774_Mouse0.91731022
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90776599
88TAF15_26573619_Chip-Seq_HEK293_Human0.90268456
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.90223446
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86724515
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84613239
92NANOG_19829295_ChIP-Seq_ESCs_Human0.83057064
93SOX2_19829295_ChIP-Seq_ESCs_Human0.83057064
94KDM5A_27292631_Chip-Seq_BREAST_Human0.82309423
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82025980
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81858120
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81601610
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80531363
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80074205
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78971632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.15522024
2MP0005671_abnormal_response_to3.09360723
3MP0006072_abnormal_retinal_apoptosis2.81465260
4MP0005645_abnormal_hypothalamus_physiol2.73293331
5MP0002102_abnormal_ear_morphology2.70999339
6MP0003787_abnormal_imprinting2.51153589
7MP0004147_increased_porphyrin_level2.41435954
8MP0008875_abnormal_xenobiotic_pharmacok2.34073388
9MP0008877_abnormal_DNA_methylation2.21954645
10MP0000372_irregular_coat_pigmentation2.12607767
11MP0003718_maternal_effect2.12562411
12MP0001835_abnormal_antigen_presentation1.90202064
13MP0010094_abnormal_chromosome_stability1.87353925
14MP0003121_genomic_imprinting1.86218057
15MP0003786_premature_aging1.84774299
16MP0003806_abnormal_nucleotide_metabolis1.83658380
17MP0003283_abnormal_digestive_organ1.82959238
18MP0001529_abnormal_vocalization1.81120309
19MP0002277_abnormal_respiratory_mucosa1.80485229
20MP0002736_abnormal_nociception_after1.78662585
21MP0008872_abnormal_physiological_respon1.76334190
22MP0003693_abnormal_embryo_hatching1.74507258
23MP0005084_abnormal_gallbladder_morpholo1.74299607
24MP0008995_early_reproductive_senescence1.73296758
25MP0003136_yellow_coat_color1.73100547
26MP0001905_abnormal_dopamine_level1.70235252
27MP0005646_abnormal_pituitary_gland1.63093691
28MP0001968_abnormal_touch/_nociception1.60803989
29MP0005253_abnormal_eye_physiology1.55941524
30MP0004145_abnormal_muscle_electrophysio1.55023160
31MP0003195_calcinosis1.54406515
32MP0004142_abnormal_muscle_tone1.53703894
33MP0005551_abnormal_eye_electrophysiolog1.52088014
34MP0002837_dystrophic_cardiac_calcinosis1.51687699
35MP0003011_delayed_dark_adaptation1.51425497
36MP0006036_abnormal_mitochondrial_physio1.48778843
37MP0009046_muscle_twitch1.48482598
38MP0003122_maternal_imprinting1.48328833
39MP0006292_abnormal_olfactory_placode1.45990107
40MP0001984_abnormal_olfaction1.45534050
41MP0002148_abnormal_hypersensitivity_rea1.43988924
42MP0006276_abnormal_autonomic_nervous1.41815865
43MP0003763_abnormal_thymus_physiology1.37641953
44MP0006035_abnormal_mitochondrial_morpho1.32030069
45MP0009785_altered_susceptibility_to1.31241372
46MP0002653_abnormal_ependyma_morphology1.30076124
47MP0005075_abnormal_melanosome_morpholog1.29985634
48MP0001800_abnormal_humoral_immune1.29881194
49MP0003186_abnormal_redox_activity1.23379975
50MP0003880_abnormal_central_pattern1.23260844
51MP0001873_stomach_inflammation1.22650370
52MP0002876_abnormal_thyroid_physiology1.21215011
53MP0001790_abnormal_immune_system1.20930016
54MP0005387_immune_system_phenotype1.20930016
55MP0001485_abnormal_pinna_reflex1.12874769
56MP0009333_abnormal_splenocyte_physiolog1.06573445
57MP0005410_abnormal_fertilization1.05722590
58MP0005000_abnormal_immune_tolerance1.04886087
59MP0009745_abnormal_behavioral_response1.04439251
60MP0000631_abnormal_neuroendocrine_gland1.01595964
61MP0002751_abnormal_autonomic_nervous0.99759673
62MP0002006_tumorigenesis0.99425319
63MP0002272_abnormal_nervous_system0.98331857
64MP0001764_abnormal_homeostasis0.97998908
65MP0002723_abnormal_immune_serum0.97428267
66MP0002420_abnormal_adaptive_immunity0.95963224
67MP0002163_abnormal_gland_morphology0.95563214
68MP0002282_abnormal_trachea_morphology0.95354637
69MP0004957_abnormal_blastocyst_morpholog0.94133084
70MP0005636_abnormal_mineral_homeostasis0.93360697
71MP0001929_abnormal_gametogenesis0.92979816
72MP0002166_altered_tumor_susceptibility0.92515432
73MP0001819_abnormal_immune_cell0.92009672
74MP0006082_CNS_inflammation0.88550184
75MP0003077_abnormal_cell_cycle0.88325598
76MP0000685_abnormal_immune_system0.86590016
77MP0004133_heterotaxia0.85994165
78MP0002638_abnormal_pupillary_reflex0.85570960
79MP0002452_abnormal_antigen_presenting0.84835247
80MP0005389_reproductive_system_phenotype0.84831083
81MP0005377_hearing/vestibular/ear_phenot0.83345146
82MP0003878_abnormal_ear_physiology0.83345146
83MP0002160_abnormal_reproductive_system0.82597035
84MP0003866_abnormal_defecation0.80500127
85MP0004742_abnormal_vestibular_system0.79283162
86MP0000716_abnormal_immune_system0.77698196
87MP0001486_abnormal_startle_reflex0.75686136
88MP0002822_catalepsy0.75517605
89MP0000689_abnormal_spleen_morphology0.74776594
90MP0009764_decreased_sensitivity_to0.74539900
91MP0000639_abnormal_adrenal_gland0.74415085
92MP0000653_abnormal_sex_gland0.73980205
93MP0002210_abnormal_sex_determination0.73923106
94MP0001986_abnormal_taste_sensitivity0.73659799
95MP0001145_abnormal_male_reproductive0.72510389
96MP0002132_abnormal_respiratory_system0.72086247
97MP0002138_abnormal_hepatobiliary_system0.71828929
98MP0008007_abnormal_cellular_replicative0.70954437
99MP0002398_abnormal_bone_marrow0.70850829
100MP0002557_abnormal_social/conspecific_i0.70640561

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.67069377
2Mitochondrial inheritance (HP:0001427)4.56525366
3Abnormal mitochondria in muscle tissue (HP:0008316)4.43428601
4Increased CSF lactate (HP:0002490)4.11344110
5Hepatocellular necrosis (HP:0001404)4.10948291
6Increased hepatocellular lipid droplets (HP:0006565)4.06669271
7Acute encephalopathy (HP:0006846)4.04525508
8Aplastic anemia (HP:0001915)4.01080351
9Hepatic necrosis (HP:0002605)3.91549219
10Progressive macrocephaly (HP:0004481)3.89409364
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60717680
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60717680
13Increased intramyocellular lipid droplets (HP:0012240)3.56825127
14Lipid accumulation in hepatocytes (HP:0006561)3.56174035
153-Methylglutaconic aciduria (HP:0003535)3.38210756
16Cerebral edema (HP:0002181)3.28145221
17Renal Fanconi syndrome (HP:0001994)3.25516800
18Type II lissencephaly (HP:0007260)3.07821199
19Pancreatic cysts (HP:0001737)2.90074127
20Increased serum lactate (HP:0002151)2.89304019
21Lactic acidosis (HP:0003128)2.85805018
22Increased muscle lipid content (HP:0009058)2.80212706
23IgG deficiency (HP:0004315)2.73679202
24Abolished electroretinogram (ERG) (HP:0000550)2.73566500
25Exertional dyspnea (HP:0002875)2.71528042
26Optic disc pallor (HP:0000543)2.67953800
27True hermaphroditism (HP:0010459)2.64985576
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.62907478
29Generalized aminoaciduria (HP:0002909)2.62366166
30Type I transferrin isoform profile (HP:0003642)2.61490591
31Degeneration of anterior horn cells (HP:0002398)2.59880055
32Abnormality of the anterior horn cell (HP:0006802)2.59880055
33Abnormal number of erythroid precursors (HP:0012131)2.56057203
34Pancreatic fibrosis (HP:0100732)2.50456119
35Respiratory failure (HP:0002878)2.47625092
36Colon cancer (HP:0003003)2.47185285
37Methylmalonic acidemia (HP:0002912)2.42897760
38Severe combined immunodeficiency (HP:0004430)2.42831616
39Nephronophthisis (HP:0000090)2.40207148
40Molar tooth sign on MRI (HP:0002419)2.36671129
41Abnormality of midbrain morphology (HP:0002418)2.36671129
42Pancytopenia (HP:0001876)2.34333074
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33810929
44Renal cortical cysts (HP:0000803)2.32940469
45Glycosuria (HP:0003076)2.32465159
46Abnormality of urine glucose concentration (HP:0011016)2.32465159
47Abnormality of the renal cortex (HP:0011035)2.31151364
48Exercise intolerance (HP:0003546)2.30736342
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30699458
50Methylmalonic aciduria (HP:0012120)2.28638646
51Lethargy (HP:0001254)2.28015623
52Abnormal protein glycosylation (HP:0012346)2.27558512
53Abnormal glycosylation (HP:0012345)2.27558512
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27558512
55Abnormal protein N-linked glycosylation (HP:0012347)2.27558512
56Increased IgM level (HP:0003496)2.21463924
57Respiratory difficulties (HP:0002880)2.19528944
58Congenital, generalized hypertrichosis (HP:0004540)2.18641220
59Reduced antithrombin III activity (HP:0001976)2.15964505
60Congenital stationary night blindness (HP:0007642)2.15785952
61Attenuation of retinal blood vessels (HP:0007843)2.15210752
62Hypoproteinemia (HP:0003075)2.10610291
63Abnormality of the renal medulla (HP:0100957)2.10204535
64Abnormality of cells of the erythroid lineage (HP:0012130)2.09508982
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08693881
66Cerebellar dysplasia (HP:0007033)2.07975320
67Elevated erythrocyte sedimentation rate (HP:0003565)2.02476866
68IgM deficiency (HP:0002850)2.00817812
69Leukodystrophy (HP:0002415)1.98640323
70Bile duct proliferation (HP:0001408)1.98299438
71Abnormal biliary tract physiology (HP:0012439)1.98299438
72Hyperglycinemia (HP:0002154)1.95303947
73Abnormality of renal resorption (HP:0011038)1.93706708
74Retinal dysplasia (HP:0007973)1.93701742
75Stomatitis (HP:0010280)1.92615589
76Hypothermia (HP:0002045)1.91263447
77Abnormal rod and cone electroretinograms (HP:0008323)1.90416366
78Hypoplasia of the pons (HP:0012110)1.90300185
79Pendular nystagmus (HP:0012043)1.90255743
80Medial flaring of the eyebrow (HP:0010747)1.90149288
81Microvesicular hepatic steatosis (HP:0001414)1.89728632
82CNS demyelination (HP:0007305)1.89655878
83Abnormality of B cell number (HP:0010975)1.89605670
84Large for gestational age (HP:0001520)1.89001201
85Ketosis (HP:0001946)1.87288307
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85636078
87Abnormality of the labia minora (HP:0012880)1.84187233
88Combined immunodeficiency (HP:0005387)1.83800631
89Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83364875
90Dicarboxylic aciduria (HP:0003215)1.83364875
91Decreased central vision (HP:0007663)1.82416763
92Abnormality of alanine metabolism (HP:0010916)1.81319518
93Hyperalaninemia (HP:0003348)1.81319518
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81319518
95Abnormality of the pons (HP:0007361)1.79487464
96Abnormality of the prostate (HP:0008775)1.78064909
97Thyroiditis (HP:0100646)1.72198449
98Constricted visual fields (HP:0001133)1.71318205
99Agammaglobulinemia (HP:0004432)1.71165097
100Abnormality of T cell number (HP:0011839)1.69411348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.52571108
2ZAK3.64301668
3TLK13.46273278
4VRK13.39630473
5BCKDK3.07583411
6BUB12.46212958
7NUAK12.45345869
8TESK22.23416060
9TXK2.21859459
10TAOK32.17063406
11MST42.14793803
12KDR2.09483079
13TSSK62.08689031
14MAP4K22.08398514
15ADRBK21.91059676
16BRSK21.64772332
17MAP3K121.61058404
18EIF2AK31.45178502
19PLK31.38338162
20GRK11.32559029
21NME11.28910401
22GRK71.26466122
23TRIM281.22036162
24CSNK1G11.13874364
25BCR1.12865301
26RPS6KA51.11156144
27CSNK1G31.09661020
28SRPK11.08907601
29FRK1.05990192
30WNK31.04609074
31PINK11.00978050
32OXSR11.00612540
33MAPKAPK50.97343067
34NEK10.96466812
35DYRK20.93374593
36KIT0.92759702
37TEC0.91910095
38ITK0.88895361
39CSNK1A1L0.87293869
40CSNK1G20.87191268
41MKNK10.86827086
42PASK0.84771173
43IKBKB0.83277776
44MAP4K10.81087432
45WEE10.80385661
46WNK40.80025271
47LIMK10.79609678
48PRKCQ0.79465182
49SYK0.77548050
50EIF2AK10.77087875
51BRSK10.74846589
52INSRR0.74283586
53CCNB10.73791503
54FES0.72346834
55TESK10.71417259
56CDC70.69322996
57DAPK10.69208608
58ATR0.68948604
59BMPR1B0.67518788
60MUSK0.65877845
61MAPK130.64332710
62PLK20.63712054
63PBK0.61761813
64PLK10.61453807
65TIE10.60189883
66TAF10.60092701
67PIK3CA0.59678530
68AURKB0.59542355
69MYLK0.59379523
70STK390.57941688
71MAPK150.57210298
72PKN10.56042339
73TNK20.55516139
74MKNK20.55393597
75ADRBK10.54929012
76PHKG10.54102067
77PHKG20.54102067
78PLK40.53526191
79NLK0.52918253
80PIM20.52818455
81MAPKAPK30.51601115
82CSNK2A10.50916586
83STK160.49825993
84TTK0.47933534
85BTK0.46457890
86PRKCG0.46262172
87AURKA0.45521201
88FLT30.45449485
89CSF1R0.44013437
90LYN0.43721056
91ARAF0.42775692
92CHEK20.42201836
93CDK80.42148920
94CSNK2A20.41432824
95GRK50.41282242
96TNIK0.41175890
97DAPK30.39627655
98PNCK0.39008051
99CSNK1A10.38213595
100MAP2K70.35714804

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.76139184
2Oxidative phosphorylation_Homo sapiens_hsa001903.93484721
3Parkinsons disease_Homo sapiens_hsa050123.36256226
4Protein export_Homo sapiens_hsa030603.03860191
5Ribosome_Homo sapiens_hsa030102.78829176
6Asthma_Homo sapiens_hsa053102.52481973
7RNA polymerase_Homo sapiens_hsa030202.49207662
8Allograft rejection_Homo sapiens_hsa053302.29919072
9Autoimmune thyroid disease_Homo sapiens_hsa053202.29025817
10Huntingtons disease_Homo sapiens_hsa050162.15329216
11Alzheimers disease_Homo sapiens_hsa050102.11627512
12Primary immunodeficiency_Homo sapiens_hsa053402.05654121
13Homologous recombination_Homo sapiens_hsa034402.05070874
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.99659652
15Graft-versus-host disease_Homo sapiens_hsa053321.85942690
16Type I diabetes mellitus_Homo sapiens_hsa049401.82120088
17Mismatch repair_Homo sapiens_hsa034301.77252072
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.73906554
19DNA replication_Homo sapiens_hsa030301.71164592
20Non-homologous end-joining_Homo sapiens_hsa034501.59919402
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56022082
22Systemic lupus erythematosus_Homo sapiens_hsa053221.55529794
23Phototransduction_Homo sapiens_hsa047441.54306783
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51484880
25Antigen processing and presentation_Homo sapiens_hsa046121.45157080
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42375610
27RNA degradation_Homo sapiens_hsa030181.40396742
28Nucleotide excision repair_Homo sapiens_hsa034201.38404165
29Fanconi anemia pathway_Homo sapiens_hsa034601.37274348
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35087892
31Cardiac muscle contraction_Homo sapiens_hsa042601.34990420
32Base excision repair_Homo sapiens_hsa034101.33721006
33Spliceosome_Homo sapiens_hsa030401.31073115
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28792773
35Propanoate metabolism_Homo sapiens_hsa006401.27948865
36Basal transcription factors_Homo sapiens_hsa030221.27493274
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24489427
38Pyrimidine metabolism_Homo sapiens_hsa002401.19691845
39One carbon pool by folate_Homo sapiens_hsa006701.17622507
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13092889
41Rheumatoid arthritis_Homo sapiens_hsa053231.12995449
42Purine metabolism_Homo sapiens_hsa002301.10856263
43Peroxisome_Homo sapiens_hsa041461.07653359
44RNA transport_Homo sapiens_hsa030130.98149165
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98017102
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.97468888
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91412758
48Butanoate metabolism_Homo sapiens_hsa006500.90430406
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90304531
50Sulfur metabolism_Homo sapiens_hsa009200.89274523
51Hematopoietic cell lineage_Homo sapiens_hsa046400.89117975
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84280778
53Collecting duct acid secretion_Homo sapiens_hsa049660.78951021
54Tryptophan metabolism_Homo sapiens_hsa003800.77932127
55Selenocompound metabolism_Homo sapiens_hsa004500.76398356
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76358881
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74856203
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70780745
59Nitrogen metabolism_Homo sapiens_hsa009100.68677767
60Pyruvate metabolism_Homo sapiens_hsa006200.67588976
61Fatty acid elongation_Homo sapiens_hsa000620.67083037
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66758888
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66084511
64Metabolic pathways_Homo sapiens_hsa011000.60034716
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.59992837
66Glutathione metabolism_Homo sapiens_hsa004800.56663432
67Alcoholism_Homo sapiens_hsa050340.55762908
68Linoleic acid metabolism_Homo sapiens_hsa005910.53604506
69Viral myocarditis_Homo sapiens_hsa054160.52862647
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52118355
71Epstein-Barr virus infection_Homo sapiens_hsa051690.49741577
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49610310
73Retinol metabolism_Homo sapiens_hsa008300.48872567
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48659426
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48438214
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47783990
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46757160
78Chemical carcinogenesis_Homo sapiens_hsa052040.46711954
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45759008
80Regulation of autophagy_Homo sapiens_hsa041400.43890639
81Olfactory transduction_Homo sapiens_hsa047400.43523740
82Caffeine metabolism_Homo sapiens_hsa002320.40106310
83Arachidonic acid metabolism_Homo sapiens_hsa005900.39581651
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38803756
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38477194
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37141577
87Folate biosynthesis_Homo sapiens_hsa007900.34705038
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33895361
89Staphylococcus aureus infection_Homo sapiens_hsa051500.33483379
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.28691126
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.27489148
92Oocyte meiosis_Homo sapiens_hsa041140.25769837
93Carbon metabolism_Homo sapiens_hsa012000.25139897
94beta-Alanine metabolism_Homo sapiens_hsa004100.23950037
95Leishmaniasis_Homo sapiens_hsa051400.19999686
96Sulfur relay system_Homo sapiens_hsa041220.19439721
97T cell receptor signaling pathway_Homo sapiens_hsa046600.19157779
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17664402
99Cell cycle_Homo sapiens_hsa041100.17179319
100p53 signaling pathway_Homo sapiens_hsa041150.16967699

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