BANK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1B cell receptor signaling pathway (GO:0050853)9.25608672
2regulation of B cell receptor signaling pathway (GO:0050855)7.84916073
3antigen processing and presentation of endogenous antigen (GO:0019883)7.57969862
4positive regulation of gamma-delta T cell activation (GO:0046645)6.74966479
5cellular response to zinc ion (GO:0071294)6.61188205
6regulation of B cell differentiation (GO:0045577)6.27662258
7B cell proliferation (GO:0042100)6.01946664
8neutrophil activation involved in immune response (GO:0002283)5.62740025
9positive thymic T cell selection (GO:0045059)5.51170372
10mature B cell differentiation (GO:0002335)5.45500124
11positive regulation of B cell differentiation (GO:0045579)5.38242262
12regulation of interferon-beta biosynthetic process (GO:0045357)5.21412128
13negative regulation of B cell proliferation (GO:0030889)5.09665805
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.09455235
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.09455235
16regulation of gamma-delta T cell differentiation (GO:0045586)4.93268261
17regulation of B cell proliferation (GO:0030888)4.90737784
18cytidine deamination (GO:0009972)4.65584161
19cytidine metabolic process (GO:0046087)4.65584161
20cytidine catabolic process (GO:0006216)4.65584161
21regulation of gamma-delta T cell activation (GO:0046643)4.64170767
22regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.45967063
23negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.40261591
24regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.38749818
25positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.36062516
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.34915906
27B cell homeostasis (GO:0001782)4.23667177
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.22556883
29cellular response to interleukin-15 (GO:0071350)4.20784004
30detection of bacterium (GO:0016045)4.20332059
31regulation of B cell apoptotic process (GO:0002902)4.19475350
32antigen receptor-mediated signaling pathway (GO:0050851)4.17285153
33regulation of interleukin-12 biosynthetic process (GO:0045075)4.16976836
34positive regulation of B cell proliferation (GO:0030890)4.13583924
35detection of other organism (GO:0098543)4.10279132
36antigen processing and presentation via MHC class Ib (GO:0002475)4.10189723
37response to interleukin-15 (GO:0070672)4.08612070
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05069949
39mature B cell differentiation involved in immune response (GO:0002313)3.99600412
40negative thymic T cell selection (GO:0045060)3.99040970
41germinal center formation (GO:0002467)3.96051711
42neutrophil activation (GO:0042119)3.95939746
43positive T cell selection (GO:0043368)3.95043058
44regulation of platelet aggregation (GO:0090330)3.92471589
45* B cell activation (GO:0042113)3.86291428
46positive regulation of mast cell activation (GO:0033005)3.85239980
47regulation of alpha-beta T cell proliferation (GO:0046640)3.84411598
48positive regulation of Rap GTPase activity (GO:0032854)3.83809911
49thymic T cell selection (GO:0045061)3.81198864
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.79824200
51positive regulation of interferon-alpha production (GO:0032727)3.79384834
52regulation of antigen processing and presentation (GO:0002577)3.79009517
53immune response-activating cell surface receptor signaling pathway (GO:0002429)3.76235606
54defense response to protozoan (GO:0042832)3.72131592
55lymph node development (GO:0048535)3.71122505
56immunoglobulin mediated immune response (GO:0016064)3.69574913
57negative T cell selection (GO:0043383)3.68022902
58purinergic nucleotide receptor signaling pathway (GO:0035590)3.68022765
59B cell mediated immunity (GO:0019724)3.62653036
60positive regulation of B cell activation (GO:0050871)3.61219344
61regulation of B cell activation (GO:0050864)3.60720999
62lymphocyte homeostasis (GO:0002260)3.60333826
63regulation of interferon-alpha production (GO:0032647)3.60259729
64regulation of germinal center formation (GO:0002634)3.59349718
65thrombin receptor signaling pathway (GO:0070493)3.56187504
66pyrimidine ribonucleoside catabolic process (GO:0046133)3.56057790
67lymphocyte proliferation (GO:0046651)3.53358724
68positive regulation of granulocyte differentiation (GO:0030854)3.52723652
69T cell selection (GO:0045058)3.51833645
70G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.49787009
71mononuclear cell proliferation (GO:0032943)3.49784618
72interferon-gamma-mediated signaling pathway (GO:0060333)3.48921631
73mast cell activation (GO:0045576)3.48053768
74regulation of mast cell activation (GO:0033003)3.47378787
75granulocyte activation (GO:0036230)3.44199489
76negative regulation of T-helper cell differentiation (GO:0045623)3.42722719
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.42722719
78negative regulation of phagocytosis (GO:0050765)3.40785851
79negative regulation of B cell apoptotic process (GO:0002903)3.40751690
80myeloid cell activation involved in immune response (GO:0002275)3.39794150
81positive regulation of antigen processing and presentation (GO:0002579)3.39744152
82respiratory burst (GO:0045730)3.39722239
83negative regulation of histone methylation (GO:0031061)3.35320081
84NIK/NF-kappaB signaling (GO:0038061)3.34789625
85regulation of interferon-gamma biosynthetic process (GO:0045072)3.33126244
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33106522
87leukocyte migration involved in inflammatory response (GO:0002523)3.32484816
88B cell differentiation (GO:0030183)3.30980833
89negative regulation of cell killing (GO:0031342)3.30013159
90negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30013159
91B cell activation involved in immune response (GO:0002312)3.27164957
92complement activation, classical pathway (GO:0006958)3.26845981
93somatic hypermutation of immunoglobulin genes (GO:0016446)3.26506308
94somatic diversification of immune receptors via somatic mutation (GO:0002566)3.26506308
95modulation by symbiont of host immune response (GO:0052553)3.24720259
96positive regulation by symbiont of host defense response (GO:0052509)3.24720259
97modulation by symbiont of host defense response (GO:0052031)3.24720259
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24720259
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24720259
100positive regulation by organism of defense response of other organism involved in symbiotic interact3.24720259
101leukocyte degranulation (GO:0043299)3.23029430
102positive regulation of interleukin-2 production (GO:0032743)3.20990018
103positive regulation of mast cell degranulation (GO:0043306)3.20646410
104positive regulation of mast cell activation involved in immune response (GO:0033008)3.20646410
105positive regulation of macrophage differentiation (GO:0045651)3.16654282
106regulation of Rap GTPase activity (GO:0032317)3.16296073
107negative regulation of lymphocyte mediated immunity (GO:0002707)3.16025808
108regulation of mast cell degranulation (GO:0043304)3.14882663
109macrophage activation involved in immune response (GO:0002281)3.12611119
110negative regulation of bone resorption (GO:0045779)3.12554608
111leukocyte proliferation (GO:0070661)3.12434161
112histamine secretion (GO:0001821)3.12426021
113Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)3.11869834
114immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00023.11869834
115Fc-gamma receptor signaling pathway (GO:0038094)3.11869834
116microglial cell activation (GO:0001774)3.11812291
117cellular response to exogenous dsRNA (GO:0071360)3.11196666
118leukocyte homeostasis (GO:0001776)3.09854335
119T cell costimulation (GO:0031295)3.09790188
120positive regulation of immunoglobulin production (GO:0002639)3.08392381
121Fc receptor mediated stimulatory signaling pathway (GO:0002431)3.07867879
122response to protozoan (GO:0001562)3.07754253
123T cell homeostasis (GO:0043029)3.06228951
124lymphocyte costimulation (GO:0031294)3.04195120
125regulation of platelet activation (GO:0010543)3.02394059
126positive regulation of type 2 immune response (GO:0002830)3.02290337
127humoral immune response (GO:0006959)3.01884355
128production of molecular mediator involved in inflammatory response (GO:0002532)3.00132290
129I-kappaB phosphorylation (GO:0007252)2.99764626
130detection of external biotic stimulus (GO:0098581)2.99646297
131regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.99546484
132negative regulation of humoral immune response (GO:0002921)2.98871054
133Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98031840
134regulation of mast cell activation involved in immune response (GO:0033006)2.97027044
135positive regulation of DNA recombination (GO:0045911)2.96241768
136tolerance induction (GO:0002507)2.94593986
137JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.94508790
138leukocyte aggregation (GO:0070486)2.94419846
139regulation of T cell receptor signaling pathway (GO:0050856)2.93495204
140autophagic vacuole fusion (GO:0000046)2.93343688
141dendritic cell chemotaxis (GO:0002407)2.93090618
142megakaryocyte development (GO:0035855)2.92490633
143cellular response to type I interferon (GO:0071357)2.91542494
144type I interferon signaling pathway (GO:0060337)2.91542494
145response to type I interferon (GO:0034340)2.90963072
146immune response-activating signal transduction (GO:0002757)2.90655955
147regulation of MHC class I biosynthetic process (GO:0045343)2.90510093
148negative regulation of alpha-beta T cell activation (GO:0046636)2.89932986
149regulation of superoxide anion generation (GO:0032928)2.89329511
150positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87811419
151dendritic cell migration (GO:0036336)2.86829938
152purinergic receptor signaling pathway (GO:0035587)2.86773496
153regulation of regulatory T cell differentiation (GO:0045589)2.83655802
154hepatocyte apoptotic process (GO:0097284)2.82914719
155cellular extravasation (GO:0045123)2.81829878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human7.13255854
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.57321390
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.20581518
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.57847747
5MYC_22102868_ChIP-Seq_BL_Human4.51408661
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse4.43861904
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.88618872
8* IRF8_27001747_Chip-Seq_BMDM_Mouse3.50470135
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44671852
10E2F7_22180533_ChIP-Seq_HELA_Human3.35016746
11VDR_21846776_ChIP-Seq_THP-1_Human3.07663764
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human3.07542507
13RUNX_20019798_ChIP-Seq_JUKART_Human2.97308143
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.94637236
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.72565542
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71462917
17MYB_26560356_Chip-Seq_TH2_Human2.56798028
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53342248
19MYB_26560356_Chip-Seq_TH1_Human2.52129352
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46095916
21MAF_26560356_Chip-Seq_TH1_Human2.42190808
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34037343
23SCL_19346495_ChIP-Seq_HPC-7_Human2.23153730
24SPI1_23547873_ChIP-Seq_NB4_Human2.18006140
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.17800951
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.16970217
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15431085
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.15396292
29VDR_24763502_ChIP-Seq_THP-1_Human2.14846646
30UTX_26944678_Chip-Seq_JUKART_Human2.14120961
31GATA1_22025678_ChIP-Seq_K562_Human2.12321987
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12219445
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.08826042
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01423946
35STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00667483
36CIITA_25753668_ChIP-Seq_RAJI_Human1.99094404
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.99066557
38TCF7_22412390_ChIP-Seq_EML_Mouse1.85405100
39SPI1_23127762_ChIP-Seq_K562_Human1.84452139
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.82327048
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.73872595
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.72160818
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71575604
44KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71061155
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68511763
46* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.63089791
47GATA3_27048872_Chip-Seq_THYMUS_Human1.61457172
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59012998
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55402432
50MAF_26560356_Chip-Seq_TH2_Human1.51354615
51NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47829235
52KDM2B_26808549_Chip-Seq_DND41_Human1.46331353
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45988927
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45890254
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45620147
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39328825
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37073770
58GATA1_19941826_ChIP-Seq_K562_Human1.36996871
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36746114
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31327493
61EZH2_22144423_ChIP-Seq_EOC_Human1.29654472
62PU_27001747_Chip-Seq_BMDM_Mouse1.28700090
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.20514292
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17021104
65GATA3_26560356_Chip-Seq_TH2_Human1.16892954
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16187583
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14050257
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09827086
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09235670
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08185835
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04079282
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02794339
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02423875
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.00721302
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00333352
76SMRT_27268052_Chip-Seq_Bcells_Human0.98699116
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.95455239
78SPI1_20517297_ChIP-Seq_HL60_Human0.94874103
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93776652
80FLI1_27457419_Chip-Seq_LIVER_Mouse0.92888027
81VDR_24787735_ChIP-Seq_THP-1_Human0.92629239
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92403117
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92019987
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.90799437
85GATA3_26560356_Chip-Seq_TH1_Human0.90549106
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90180686
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89453286
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89220278
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88974867
90STAT1_20625510_ChIP-Seq_HELA_Human0.87505189
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87292932
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86354143
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86001994
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85812497
95FOXP3_21729870_ChIP-Seq_TREG_Human0.85593101
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85487242
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84287402
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83550460
99E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82270191
100ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81013988
101ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80162383
102BCL6_27268052_Chip-Seq_Bcells_Human0.79611528
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78043334
104P300_27268052_Chip-Seq_Bcells_Human0.77583879
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.77524460
106PRDM14_20953172_ChIP-Seq_ESCs_Human0.76893011
107CEBPB_22108803_ChIP-Seq_LS180_Human0.74805700
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73632506
109BCAT_22108803_ChIP-Seq_LS180_Human0.73378694
110ETS1_22383799_ChIP-Seq_G1ME_Mouse0.73338317
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73232666
112KDM5A_27292631_Chip-Seq_BREAST_Human0.72927180
113SALL4_22934838_ChIP-ChIP_CD34+_Human0.72483740
114RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.72361970
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72297815
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72260923
117NCOR1_26117541_ChIP-Seq_K562_Human0.72056202
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71959335
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70638565
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68387873
121GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68321016
122GATA2_19941826_ChIP-Seq_K562_Human0.67686239
123SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.67548636
124KDM2B_26808549_Chip-Seq_JURKAT_Human0.66482115
125E2F1_21310950_ChIP-Seq_MCF-7_Human0.66239544
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66138129
127VDR_23849224_ChIP-Seq_CD4+_Human0.66089149
128* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65783003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.91866550
2MP0001790_abnormal_immune_system5.09289225
3MP0005387_immune_system_phenotype5.09289225
4* MP0001800_abnormal_humoral_immune4.99473745
5MP0003724_increased_susceptibility_to3.98051099
6MP0000685_abnormal_immune_system3.84917291
7* MP0002452_abnormal_antigen_presenting3.81083974
8MP0003303_peritoneal_inflammation3.49527862
9MP0005000_abnormal_immune_tolerance3.43193378
10MP0005671_abnormal_response_to3.28640329
11* MP0002723_abnormal_immune_serum3.15742506
12* MP0002420_abnormal_adaptive_immunity3.08850774
13* MP0001819_abnormal_immune_cell2.98348527
14* MP0002398_abnormal_bone_marrow2.85372301
15* MP0000716_abnormal_immune_system2.65203926
16* MP0000689_abnormal_spleen_morphology2.57201643
17MP0003763_abnormal_thymus_physiology2.34079367
18MP0008004_abnormal_stomach_pH2.26801865
19MP0002419_abnormal_innate_immunity2.18587496
20MP0005025_abnormal_response_to2.17933679
21* MP0002429_abnormal_blood_cell2.15090224
22MP0002722_abnormal_immune_system2.13324300
23MP0002148_abnormal_hypersensitivity_rea2.09707419
24MP0002396_abnormal_hematopoietic_system2.05132197
25MP0004510_myositis2.02711814
26MP0001873_stomach_inflammation2.01010720
27MP0002166_altered_tumor_susceptibility1.97852993
28MP0003183_abnormal_peptide_metabolism1.97284981
29MP0003300_gastrointestinal_ulcer1.93987594
30MP0001853_heart_inflammation1.79001423
31MP0009785_altered_susceptibility_to1.78507462
32MP0002405_respiratory_system_inflammati1.78308003
33MP0001845_abnormal_inflammatory_respons1.75840969
34MP0000569_abnormal_digit_pigmentation1.72193887
35MP0003436_decreased_susceptibility_to1.64426767
36MP0008057_abnormal_DNA_replication1.55908612
37MP0004808_abnormal_hematopoietic_stem1.55047241
38MP0005464_abnormal_platelet_physiology1.53648593
39MP0010155_abnormal_intestine_physiology1.49507554
40MP0005310_abnormal_salivary_gland1.48903517
41MP0001851_eye_inflammation1.41482254
42MP0000703_abnormal_thymus_morphology1.41010372
43MP0004947_skin_inflammation1.36887510
44MP0002006_tumorigenesis1.35627362
45MP0005174_abnormal_tail_pigmentation1.32175560
46MP0004381_abnormal_hair_follicle1.31652285
47MP0003787_abnormal_imprinting1.28820665
48MP0002933_joint_inflammation1.26494409
49MP0003866_abnormal_defecation1.25891263
50MP0000465_gastrointestinal_hemorrhage1.25158024
51MP0009333_abnormal_splenocyte_physiolog1.15093271
52MP0010234_abnormal_vibrissa_follicle1.10634912
53MP0000858_altered_metastatic_potential1.09723153
54MP0004883_abnormal_blood_vessel1.09416989
55MP0002136_abnormal_kidney_physiology1.07308313
56MP0004130_abnormal_muscle_cell1.05686796
57MP0005084_abnormal_gallbladder_morpholo1.04034652
58MP0000015_abnormal_ear_pigmentation1.02421537
59MP0002132_abnormal_respiratory_system1.01702715
60MP0008469_abnormal_protein_level1.00392402
61MP0003045_fibrosis0.98861366
62MP0003091_abnormal_cell_migration0.97519768
63MP0008260_abnormal_autophagy0.95869528
64MP0002909_abnormal_adrenal_gland0.94828384
65MP0002019_abnormal_tumor_incidence0.94189749
66MP0010094_abnormal_chromosome_stability0.93747890
67MP0002928_abnormal_bile_duct0.93171527
68MP0003077_abnormal_cell_cycle0.92377619
69MP0010352_gastrointestinal_tract_polyps0.91226797
70MP0001879_abnormal_lymphatic_vessel0.90236049
71MP0002095_abnormal_skin_pigmentation0.85072287
72MP0000343_altered_response_to0.84078659
73MP0000230_abnormal_systemic_arterial0.83916154
74MP0003011_delayed_dark_adaptation0.78432193
75MP0003252_abnormal_bile_duct0.76986315
76MP0008874_decreased_physiological_sensi0.75801418
77MP0003191_abnormal_cellular_cholesterol0.75676298
78MP0003172_abnormal_lysosome_physiology0.74832169
79MP0002998_abnormal_bone_remodeling0.71077400
80MP0009278_abnormal_bone_marrow0.70800113
81MP0008961_abnormal_basal_metabolism0.70498013
82MP0001765_abnormal_ion_homeostasis0.70004433
83MP0000767_abnormal_smooth_muscle0.69873176
84MP0001986_abnormal_taste_sensitivity0.69300002
85MP0005381_digestive/alimentary_phenotyp0.67261541
86MP0006082_CNS_inflammation0.65402774
87MP0005164_abnormal_response_to0.64084848
88MP0008872_abnormal_physiological_respon0.63523664
89MP0009764_decreased_sensitivity_to0.63388987
90MP0002138_abnormal_hepatobiliary_system0.63141635
91MP0005451_abnormal_body_composition0.62277272
92MP0000249_abnormal_blood_vessel0.60761074
93MP0000490_abnormal_crypts_of0.60619475
94MP0003566_abnormal_cell_adhesion0.60251165
95MP0003638_abnormal_response/metabolism_0.59809914
96MP0003828_pulmonary_edema0.59155107
97MP0008877_abnormal_DNA_methylation0.59071631
98MP0005621_abnormal_cell_physiology0.58582481
99MP0002168_other_aberrant_phenotype0.58352354
100MP0005166_decreased_susceptibility_to0.58089767
101MP0005075_abnormal_melanosome_morpholog0.57944680
102MP0006054_spinal_hemorrhage0.55617582
103MP0003656_abnormal_erythrocyte_physiolo0.55550496
104MP0009642_abnormal_blood_homeostasis0.55395576
105MP0001663_abnormal_digestive_system0.54167857
106MP0008058_abnormal_DNA_repair0.53193823
107MP0010329_abnormal_lipoprotein_level0.52844115
108MP0005167_abnormal_blood-brain_barrier0.52091903
109MP0000371_diluted_coat_color0.51947528
110MP0001533_abnormal_skeleton_physiology0.51607558
111MP0009765_abnormal_xenobiotic_induced0.51314719
112MP0003075_altered_response_to0.51271332
113MP0002332_abnormal_exercise_endurance0.50385865
114MP0005397_hematopoietic_system_phenotyp0.49099414
115MP0001545_abnormal_hematopoietic_system0.49099414
116MP0005076_abnormal_cell_differentiation0.48578981
117MP0005058_abnormal_lysosome_morphology0.48267963
118MP0000350_abnormal_cell_proliferation0.47243256
119MP0003693_abnormal_embryo_hatching0.46983796
120MP0000609_abnormal_liver_physiology0.43996743
121MP0003453_abnormal_keratinocyte_physiol0.43450732
122MP0002135_abnormal_kidney_morphology0.42106227
123MP0000313_abnormal_cell_death0.42076017
124MP0002009_preneoplasia0.41896905
125MP0009763_increased_sensitivity_to0.41080521
126MP0002083_premature_death0.40436260
127MP0003111_abnormal_nucleus_morphology0.39941846

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.28103096
2Gastrointestinal stroma tumor (HP:0100723)8.71945749
3Recurrent sinusitis (HP:0011108)6.42134770
4Colitis (HP:0002583)6.37448306
5Recurrent bronchitis (HP:0002837)6.15917438
6Cellulitis (HP:0100658)5.78353704
7IgM deficiency (HP:0002850)5.43237209
8Lymphopenia (HP:0001888)5.39512565
9Inflammation of the large intestine (HP:0002037)5.27054035
10Emphysema (HP:0002097)5.15052602
11Abnormality of cells of the lymphoid lineage (HP:0012140)5.12215124
12Abnormal delayed hypersensitivity skin test (HP:0002963)5.10286108
13Gastrointestinal inflammation (HP:0004386)5.01849668
14Verrucae (HP:0200043)4.88283595
15Papilloma (HP:0012740)4.88283595
16Recurrent viral infections (HP:0004429)4.82935898
17Petechiae (HP:0000967)4.68255165
18Panhypogammaglobulinemia (HP:0003139)4.67165211
19Epistaxis (HP:0000421)4.65595973
20IgA deficiency (HP:0002720)4.51249561
21Vasculitis (HP:0002633)4.48565205
22Meningitis (HP:0001287)4.41675781
23Chronic sinusitis (HP:0011109)4.24671428
24Abnormal platelet volume (HP:0011876)4.21845624
25Menorrhagia (HP:0000132)4.18223181
26Restrictive lung disease (HP:0002091)4.10885762
27Recurrent lower respiratory tract infections (HP:0002783)4.02390262
28Increased mean platelet volume (HP:0011877)4.01182217
29Purpura (HP:0000979)3.98906587
30Recurrent abscess formation (HP:0002722)3.96299252
31Recurrent pneumonia (HP:0006532)3.95859226
32Stomatitis (HP:0010280)3.91437881
33Recurrent bacterial skin infections (HP:0005406)3.87485705
34Chronic mucocutaneous candidiasis (HP:0002728)3.82379010
35Recurrent cutaneous fungal infections (HP:0011370)3.82379010
36Chronic otitis media (HP:0000389)3.77572196
37Osteomyelitis (HP:0002754)3.61924908
38Recurrent otitis media (HP:0000403)3.56834702
39Recurrent fungal infections (HP:0002841)3.51472225
40Bronchitis (HP:0012387)3.50763079
41Small epiphyses (HP:0010585)3.43932449
42Abnormality of macrophages (HP:0004311)3.40869007
43Mediastinal lymphadenopathy (HP:0100721)3.29720625
44Recurrent skin infections (HP:0001581)3.28753892
45Chronic diarrhea (HP:0002028)3.21762678
46Elevated erythrocyte sedimentation rate (HP:0003565)3.19918774
47Myositis (HP:0100614)3.19157450
48Leukopenia (HP:0001882)3.18124212
49Optic neuritis (HP:0100653)3.18027621
50Retrobulbar optic neuritis (HP:0100654)3.18027621
51Mitral stenosis (HP:0001718)3.16182985
52Abnormality of the fingertips (HP:0001211)3.14753143
53Viral hepatitis (HP:0006562)3.07347437
54IgG deficiency (HP:0004315)3.06420439
55Thyroiditis (HP:0100646)3.06069268
56Abnormality of the prostate (HP:0008775)3.03815119
57B lymphocytopenia (HP:0010976)2.95509502
58Abnormality of B cell number (HP:0010975)2.95509502
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.95398417
60Orchitis (HP:0100796)2.95118580
61Sepsis (HP:0100806)2.92948689
62Eczematoid dermatitis (HP:0000976)2.90335891
63Lymphoma (HP:0002665)2.89429639
64Abnormality of T cell physiology (HP:0011840)2.85595650
65Autoimmune thrombocytopenia (HP:0001973)2.80193542
66Leukocytosis (HP:0001974)2.75015026
67Gastrointestinal infarctions (HP:0005244)2.73531210
68Increased IgM level (HP:0003496)2.72075856
69Abnormality of T cells (HP:0002843)2.69031196
70Abnormal platelet function (HP:0011869)2.67811703
71Impaired platelet aggregation (HP:0003540)2.67811703
72Abnormality of eosinophils (HP:0001879)2.65126246
73Granulocytopenia (HP:0001913)2.60583566
74Encephalitis (HP:0002383)2.56055601
75Severe combined immunodeficiency (HP:0004430)2.54675812
76Hyperlipoproteinemia (HP:0010980)2.46140973
77Interstitial pulmonary disease (HP:0006530)2.37039488
78Vertebral arch anomaly (HP:0008438)2.36538594
79Urticaria (HP:0001025)2.34761119
80Pulmonary infiltrates (HP:0002113)2.33944119
81T lymphocytopenia (HP:0005403)2.33591704
82Abnormality of T cell number (HP:0011839)2.32619143
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31926049
84Obstructive lung disease (HP:0006536)2.29940034
85Chronic obstructive pulmonary disease (HP:0006510)2.29940034
86Thrombocytosis (HP:0001894)2.29287416
87Autoimmune hemolytic anemia (HP:0001890)2.28369725
88Joint swelling (HP:0001386)2.23664347
89Pulmonary embolism (HP:0002204)2.22873037
90Keratoconjunctivitis sicca (HP:0001097)2.22770813
91Hypoplasia of the thymus (HP:0000778)2.21187889
92Recurrent gram-negative bacterial infections (HP:0005420)2.20898731
93Keratoconjunctivitis (HP:0001096)2.20312858
94Flattened epiphyses (HP:0003071)2.17889468
95Papilledema (HP:0001085)2.17156945
96Pustule (HP:0200039)2.16471383
97Skin ulcer (HP:0200042)2.13999994
98Arthralgia (HP:0002829)2.13750343
99Hemoptysis (HP:0002105)2.12676504
100Skin rash (HP:0000988)2.12095608
101Conjunctival telangiectasia (HP:0000524)2.10518291
102Hematochezia (HP:0002573)2.07533622
103Increased IgE level (HP:0003212)2.04814737
104Periodontitis (HP:0000704)2.04546459
105Spontaneous hematomas (HP:0007420)2.04200033
106Nasal polyposis (HP:0100582)2.03542649
107Abnormality of small intestinal villus morphology (HP:0011472)2.02395252
108Villous atrophy (HP:0011473)2.02395252
109Abnormality of the vasculature of the conjunctiva (HP:0008054)2.01549644
110Neutropenia (HP:0001875)2.00210151
111Abnormality of the pleura (HP:0002103)1.97324700
112Stomach cancer (HP:0012126)1.96365299
113Visual hallucinations (HP:0002367)1.94625626
114Xerostomia (HP:0000217)1.92008361
115Poikilocytosis (HP:0004447)1.91590793
116Fatigue (HP:0012378)1.86318598
117Hepatitis (HP:0012115)1.86166816
118Irregular vertebral endplates (HP:0003301)1.84939054
119Arthropathy (HP:0003040)1.78642425
120Absent epiphyses (HP:0010577)1.78614352
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78614352
122Myocardial infarction (HP:0001658)1.77215500
123Ulnar bowing (HP:0003031)1.77157087
124Resting tremor (HP:0002322)1.73386891
125Gingivitis (HP:0000230)1.66565753
126Prolonged bleeding time (HP:0003010)1.65475555
127Chest pain (HP:0100749)1.64647847
128Abnormality of the nasal mucosa (HP:0000433)1.63956387
129Acrocyanosis (HP:0001063)1.60422408
130Arterial thrombosis (HP:0004420)1.57338649
131Gingival bleeding (HP:0000225)1.55470136
132Basal cell carcinoma (HP:0002671)1.55382919
133Mucosal telangiectasiae (HP:0100579)1.53281498
134Eosinophilia (HP:0001880)1.52898179
135Abnormality of the intervertebral disk (HP:0005108)1.47168300
136Absent frontal sinuses (HP:0002688)1.45786311
137Aortic regurgitation (HP:0001659)1.45737495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K17.20074131
2BLK3.24201091
3GRK63.15364310
4CSF1R3.09310923
5MAP3K132.94084440
6RIPK42.85090642
7SYK2.75313815
8BTK2.66579443
9ERN12.61659631
10STK102.54530095
11LRRK22.53016382
12BMPR1B2.32769374
13TXK2.32167508
14MAP3K142.20544137
15TYK22.07419869
16JAK11.99928443
17MAP3K101.97378294
18IRAK11.83890848
19KIT1.81298107
20SIK21.80352531
21IRAK31.80121182
22LYN1.74361336
23GRK11.69306719
24CDK121.63178452
25TGFBR21.56854927
26CSK1.52341982
27MST41.49784532
28HCK1.49724890
29TEC1.38397988
30IKBKB1.36907517
31JAK31.35033762
32IRAK41.32910537
33CDK191.31209647
34PIK3CG1.29836497
35ITK1.26880192
36IRAK21.25968630
37PRKCQ1.25809730
38MARK31.25783581
39CLK11.19462745
40MATK1.18396674
41TBK11.17133070
42LCK1.12727345
43ZAP701.10315918
44SIK31.09544175
45EEF2K1.07887972
46EIF2AK31.07637699
47FES1.05065198
48PTK2B1.04497398
49PRKCH1.02490957
50BRD41.01416460
51CDC42BPA0.97952637
52FGFR30.96207313
53CAMK1D0.92684895
54BMX0.90988774
55IKBKE0.90055178
56TESK20.89956509
57PIM10.87552521
58CAMK1G0.84864751
59MAP3K30.83462906
60CHUK0.82779251
61TNK20.78949628
62MAPK70.77659363
63MAP3K90.77345662
64TRPM70.76199391
65FRK0.74545694
66FGFR40.69214883
67RPS6KA40.63841742
68ALK0.63580230
69CCNB10.63227706
70HIPK20.62806816
71FGR0.62570267
72PRPF4B0.60459191
73MAPK120.60438735
74PDK10.59854347
75MYLK0.59224887
76GRK50.59165858
77SIK10.58004211
78ACVR1B0.57964121
79ABL10.57727472
80CDK90.56092955
81ADRBK20.54738990
82MELK0.53708637
83TAOK10.51626258
84MARK20.50968355
85PRKD20.50847043
86MAP3K10.50265995
87INSR0.50088932
88PDPK10.49845458
89MAPKAPK30.49409991
90NEK20.47757397
91TLK10.46755259
92FYN0.46062313
93SGK30.44747874
94CDK40.43753707
95EGFR0.40605083
96PASK0.39400866
97PRKCD0.38911671
98WNK10.38418585
99CSNK1A1L0.38015496
100MAP2K30.37563886
101STK40.35987151
102BMPR20.34616867
103MAP2K20.34393748
104JAK20.34005281
105PRKCI0.33157706
106CDK60.32960640
107MAP3K80.32728804
108MAPKAPK20.31021312
109MAP3K110.30628238
110MAP3K70.30469678
111CAMKK10.30015561
112ADRBK10.29913084
113EPHB10.28741375
114TAOK30.28168341
115PRKD10.27812283
116NUAK10.27652121
117CDK30.27634554
118IGF1R0.27497303
119CAMKK20.26995846
120CDK80.26614372
121TGFBR10.25797575
122ATR0.25380779
123NEK90.23134879
124SCYL20.22496537
125CSNK1G10.22438322
126MAPK110.22205296
127SGK20.20359216
128NLK0.20045621
129PTK60.19728975
130PKN10.19110657
131DYRK1B0.18425311
132YES10.17976263
133TTN0.17856535
134MAPK30.17355653

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046626.41766902
2Primary immunodeficiency_Homo sapiens_hsa053406.30836219
3Asthma_Homo sapiens_hsa053103.89493966
4Graft-versus-host disease_Homo sapiens_hsa053323.70903197
5Hematopoietic cell lineage_Homo sapiens_hsa046403.41092577
6NF-kappa B signaling pathway_Homo sapiens_hsa040643.10409176
7Type I diabetes mellitus_Homo sapiens_hsa049402.92172269
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.88952276
9Osteoclast differentiation_Homo sapiens_hsa043802.29294354
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.27348911
11Antigen processing and presentation_Homo sapiens_hsa046122.19862545
12Leishmaniasis_Homo sapiens_hsa051402.03932109
13T cell receptor signaling pathway_Homo sapiens_hsa046601.84580976
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82358612
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77700977
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58885336
17Chemokine signaling pathway_Homo sapiens_hsa040621.56152063
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52531087
19Herpes simplex infection_Homo sapiens_hsa051681.51780891
20Tuberculosis_Homo sapiens_hsa051521.50796493
21Measles_Homo sapiens_hsa051621.50290559
22Base excision repair_Homo sapiens_hsa034101.41499884
23Rheumatoid arthritis_Homo sapiens_hsa053231.40701761
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.30640578
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27185023
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.27173333
27Epstein-Barr virus infection_Homo sapiens_hsa051691.26493857
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25147742
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21872115
30Non-homologous end-joining_Homo sapiens_hsa034501.16563038
31Platelet activation_Homo sapiens_hsa046111.15407675
32Influenza A_Homo sapiens_hsa051641.13455317
33Non-small cell lung cancer_Homo sapiens_hsa052231.13429373
34Phagosome_Homo sapiens_hsa041451.12799973
35Hepatitis B_Homo sapiens_hsa051611.12116224
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.12104921
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.10167762
38Mismatch repair_Homo sapiens_hsa034301.10021165
39Toxoplasmosis_Homo sapiens_hsa051451.08540244
40Shigellosis_Homo sapiens_hsa051311.04641208
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04058606
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98992304
43Pancreatic cancer_Homo sapiens_hsa052120.98900681
44African trypanosomiasis_Homo sapiens_hsa051430.97123669
45Apoptosis_Homo sapiens_hsa042100.94815499
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.91728633
47Chronic myeloid leukemia_Homo sapiens_hsa052200.90193526
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90037766
49Acute myeloid leukemia_Homo sapiens_hsa052210.85350260
50Viral myocarditis_Homo sapiens_hsa054160.84300038
51Staphylococcus aureus infection_Homo sapiens_hsa051500.83739529
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83303362
53Viral carcinogenesis_Homo sapiens_hsa052030.83093783
54Arachidonic acid metabolism_Homo sapiens_hsa005900.82343578
55Lysine degradation_Homo sapiens_hsa003100.79516897
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78442951
57Malaria_Homo sapiens_hsa051440.77711854
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75080332
59Pertussis_Homo sapiens_hsa051330.74428267
60TNF signaling pathway_Homo sapiens_hsa046680.74332663
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70537996
62HTLV-I infection_Homo sapiens_hsa051660.69638323
63Hepatitis C_Homo sapiens_hsa051600.68893378
64Other glycan degradation_Homo sapiens_hsa005110.67939320
65DNA replication_Homo sapiens_hsa030300.66445686
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65565458
67Inositol phosphate metabolism_Homo sapiens_hsa005620.64181527
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.62792160
69Salmonella infection_Homo sapiens_hsa051320.61637512
70Linoleic acid metabolism_Homo sapiens_hsa005910.61604374
71Phototransduction_Homo sapiens_hsa047440.60335213
72MAPK signaling pathway_Homo sapiens_hsa040100.59386932
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57711936
74Homologous recombination_Homo sapiens_hsa034400.56644164
75VEGF signaling pathway_Homo sapiens_hsa043700.55605999
76Notch signaling pathway_Homo sapiens_hsa043300.54533389
77Allograft rejection_Homo sapiens_hsa053300.54062845
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.51760434
79Systemic lupus erythematosus_Homo sapiens_hsa053220.50871210
80Small cell lung cancer_Homo sapiens_hsa052220.50708620
81Nitrogen metabolism_Homo sapiens_hsa009100.50513282
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50212252
83Fanconi anemia pathway_Homo sapiens_hsa034600.50067390
84Olfactory transduction_Homo sapiens_hsa047400.49307220
85MicroRNAs in cancer_Homo sapiens_hsa052060.48924134
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48836358
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.48188837
88Dorso-ventral axis formation_Homo sapiens_hsa043200.47852058
89FoxO signaling pathway_Homo sapiens_hsa040680.47483117
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47220284
91Serotonergic synapse_Homo sapiens_hsa047260.45812542
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44099464
93Legionellosis_Homo sapiens_hsa051340.42382970
94Insulin resistance_Homo sapiens_hsa049310.42255732
95Glycerolipid metabolism_Homo sapiens_hsa005610.42106924
96Endocytosis_Homo sapiens_hsa041440.40990889
97Glioma_Homo sapiens_hsa052140.40969189
98Colorectal cancer_Homo sapiens_hsa052100.40263060
99mTOR signaling pathway_Homo sapiens_hsa041500.39716931
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38268956
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.37940074
102Prolactin signaling pathway_Homo sapiens_hsa049170.37815983
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36410907
104Complement and coagulation cascades_Homo sapiens_hsa046100.36183875
105Ether lipid metabolism_Homo sapiens_hsa005650.35752380
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.35067762
107Proteoglycans in cancer_Homo sapiens_hsa052050.34349611
108Regulation of autophagy_Homo sapiens_hsa041400.34251757
109Pancreatic secretion_Homo sapiens_hsa049720.34164914
110p53 signaling pathway_Homo sapiens_hsa041150.33707021
111Prostate cancer_Homo sapiens_hsa052150.31591748
112Morphine addiction_Homo sapiens_hsa050320.31180462
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30450958
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.29766571
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28994407
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28715822
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28373713
118Renal cell carcinoma_Homo sapiens_hsa052110.27461046
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26498890
120Ribosome_Homo sapiens_hsa030100.26197410
121GnRH signaling pathway_Homo sapiens_hsa049120.25180793
122Autoimmune thyroid disease_Homo sapiens_hsa053200.24825118
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24578063
124Spliceosome_Homo sapiens_hsa030400.24444178
125Choline metabolism in cancer_Homo sapiens_hsa052310.24251633
126ABC transporters_Homo sapiens_hsa020100.23412255
127Collecting duct acid secretion_Homo sapiens_hsa049660.22032453
128Ras signaling pathway_Homo sapiens_hsa040140.19679515
129Long-term depression_Homo sapiens_hsa047300.19416864
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17387052
131Cholinergic synapse_Homo sapiens_hsa047250.14766485
132Gap junction_Homo sapiens_hsa045400.13891452

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