BANP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-histidine modification (GO:0018202)6.16769472
2negative regulation of interleukin-12 production (GO:0032695)4.70708579
3positive regulation of vasculogenesis (GO:2001214)4.59706901
4positive regulation of gamma-delta T cell activation (GO:0046645)4.41627269
5response to peptidoglycan (GO:0032494)4.33568239
6ribosomal small subunit assembly (GO:0000028)4.32569508
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02648840
8immunoglobulin mediated immune response (GO:0016064)3.99959016
9regulation of nuclear cell cycle DNA replication (GO:0033262)3.86556243
10DNA replication checkpoint (GO:0000076)3.84755837
11CENP-A containing nucleosome assembly (GO:0034080)3.81131297
12mitotic metaphase plate congression (GO:0007080)3.79820461
13macrophage activation involved in immune response (GO:0002281)3.78390525
14neutrophil activation involved in immune response (GO:0002283)3.77414988
15DNA strand elongation involved in DNA replication (GO:0006271)3.74975002
16chromatin remodeling at centromere (GO:0031055)3.73895195
17attachment of spindle microtubules to kinetochore (GO:0008608)3.70877860
18spliceosomal complex assembly (GO:0000245)3.68723085
19DNA strand elongation (GO:0022616)3.60756042
20lipopolysaccharide biosynthetic process (GO:0009103)3.56410337
21kinetochore assembly (GO:0051382)3.53826369
22metaphase plate congression (GO:0051310)3.53290415
23defense response to protozoan (GO:0042832)3.50850971
24response to protozoan (GO:0001562)3.47827166
25maturation of SSU-rRNA (GO:0030490)3.46764946
26telomere maintenance via semi-conservative replication (GO:0032201)3.45995095
27kinetochore organization (GO:0051383)3.41511729
28granulocyte activation (GO:0036230)3.41323132
29DNA replication-independent nucleosome organization (GO:0034724)3.37461945
30DNA replication-independent nucleosome assembly (GO:0006336)3.37461945
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37046084
32DNA replication initiation (GO:0006270)3.35905073
33mitotic chromosome condensation (GO:0007076)3.33674178
34regulation of chronic inflammatory response (GO:0002676)3.33439337
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32850414
36establishment of chromosome localization (GO:0051303)3.32523650
37type I interferon signaling pathway (GO:0060337)3.31668018
38cellular response to type I interferon (GO:0071357)3.31668018
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31625258
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.31625258
41modulation by symbiont of host immune response (GO:0052553)3.31625258
42positive regulation by symbiont of host defense response (GO:0052509)3.31625258
43modulation by symbiont of host defense response (GO:0052031)3.31625258
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31625258
45spliceosomal snRNP assembly (GO:0000387)3.30871997
46mismatch repair (GO:0006298)3.30553247
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30117212
48negative regulation of cell killing (GO:0031342)3.30117212
49response to type I interferon (GO:0034340)3.29642821
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29139975
51termination of RNA polymerase III transcription (GO:0006386)3.28198059
52transcription elongation from RNA polymerase III promoter (GO:0006385)3.28198059
53positive regulation of heat generation (GO:0031652)3.26607838
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25021700
55telomere maintenance via recombination (GO:0000722)3.24860011
56B cell mediated immunity (GO:0019724)3.24036559
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23644886
58regulation of gamma-delta T cell activation (GO:0046643)3.23457285
59protein K6-linked ubiquitination (GO:0085020)3.22535013
60positive regulation of release of cytochrome c from mitochondria (GO:0090200)3.22476752
61neutrophil activation (GO:0042119)3.22188673
62positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19063664
63regulation of hexokinase activity (GO:1903299)3.18719885
64regulation of glucokinase activity (GO:0033131)3.18719885
65meiotic chromosome segregation (GO:0045132)3.18224398
66positive regulation of myoblast differentiation (GO:0045663)3.17679959
67cotranslational protein targeting to membrane (GO:0006613)3.17472344
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17282398
69telomere maintenance via telomere lengthening (GO:0010833)3.17215590
70regulation of vitamin D biosynthetic process (GO:0060556)3.16826982
71viral transcription (GO:0019083)3.16806432
72DNA deamination (GO:0045006)3.16671507
73protein targeting to ER (GO:0045047)3.12685666
74regulation of interferon-alpha production (GO:0032647)3.11728411
75histone exchange (GO:0043486)3.10399140
76negative regulation of cytokine production involved in immune response (GO:0002719)3.10198918
77establishment of integrated proviral latency (GO:0075713)3.09526887
78histone H2A acetylation (GO:0043968)3.09255621
79myeloid cell activation involved in immune response (GO:0002275)3.06964428
80lactate metabolic process (GO:0006089)3.06177107
81folic acid-containing compound biosynthetic process (GO:0009396)3.05630523
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05507167
83negative regulation of sister chromatid segregation (GO:0033046)3.05507167
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.05507167
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05507167
86viral mRNA export from host cell nucleus (GO:0046784)3.05461372
87translational termination (GO:0006415)3.05324102
88protein localization to kinetochore (GO:0034501)3.04239428
89regulation of B cell receptor signaling pathway (GO:0050855)3.03614158
90mitotic sister chromatid segregation (GO:0000070)3.03201057
91histone mRNA metabolic process (GO:0008334)3.02799141
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.02798604
93mitotic spindle assembly checkpoint (GO:0007094)3.02279281
94spindle checkpoint (GO:0031577)3.01712775
95negative regulation of chromosome segregation (GO:0051985)3.01511538
96spindle assembly checkpoint (GO:0071173)3.01509037
97mitotic recombination (GO:0006312)3.01506093
98positive regulation of antigen processing and presentation (GO:0002579)2.99487579
99pre-miRNA processing (GO:0031054)2.99300237
100DNA double-strand break processing (GO:0000729)2.99061360
101regulation of T-helper 1 cell differentiation (GO:0045625)2.97988199
102regulation of vasculogenesis (GO:2001212)2.97677760
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97488707
104histone H4-K12 acetylation (GO:0043983)2.95486475
105regulation of interferon-beta biosynthetic process (GO:0045357)2.94817868
106lipopolysaccharide metabolic process (GO:0008653)2.93754223
107intra-S DNA damage checkpoint (GO:0031573)2.93676075
108transcription-coupled nucleotide-excision repair (GO:0006283)2.92584741
109NIK/NF-kappaB signaling (GO:0038061)2.91567728
110mature B cell differentiation involved in immune response (GO:0002313)2.90955388
111protein localization to endoplasmic reticulum (GO:0070972)2.90944245
112mitotic spindle checkpoint (GO:0071174)2.90273486
113tryptophan catabolic process (GO:0006569)2.89858896
114indole-containing compound catabolic process (GO:0042436)2.89858896
115indolalkylamine catabolic process (GO:0046218)2.89858896
116positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89185427
117proteasome assembly (GO:0043248)2.88930768
118regulation of cytokine secretion involved in immune response (GO:0002739)2.87986423
119response to muramyl dipeptide (GO:0032495)2.86732796
120macrophage activation (GO:0042116)2.82782930
121ATP-dependent chromatin remodeling (GO:0043044)2.81893508
122telomere maintenance via telomerase (GO:0007004)2.81309336
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80871911
124DNA unwinding involved in DNA replication (GO:0006268)2.80842794
125interferon-gamma-mediated signaling pathway (GO:0060333)2.80604084
126regulation of antigen processing and presentation (GO:0002577)2.79424322
127rRNA modification (GO:0000154)2.76763334
1287-methylguanosine RNA capping (GO:0009452)2.76579287
129RNA capping (GO:0036260)2.76579287
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.76314835
131T-helper 1 type immune response (GO:0042088)2.75714217
132translational initiation (GO:0006413)2.75215972
133sister chromatid segregation (GO:0000819)2.75117392
134detection of other organism (GO:0098543)2.74582754
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74508938
1367-methylguanosine mRNA capping (GO:0006370)2.74272233
137germinal center formation (GO:0002467)2.73908390
138regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73828391
139DNA catabolic process, exonucleolytic (GO:0000738)2.73762176
140detection of molecule of bacterial origin (GO:0032490)2.73279903
141positive regulation of chemokine biosynthetic process (GO:0045080)2.73056588
142translational elongation (GO:0006414)2.72753536
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71691632
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71267280
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.71267280
146maturation of 5.8S rRNA (GO:0000460)2.70971282
147negative regulation of histone methylation (GO:0031061)2.70921232
148nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70878030
149ribosomal small subunit biogenesis (GO:0042274)2.69906626
150regulation of chemokine biosynthetic process (GO:0045073)2.68022496
151mitotic nuclear envelope disassembly (GO:0007077)2.67924178
152regulation of interleukin-12 production (GO:0032655)2.67750815
153negative regulation of T cell mediated immunity (GO:0002710)2.66589569
154negative regulation of Notch signaling pathway (GO:0045746)2.65926351
155regulation of fever generation (GO:0031620)2.65867334
156positive regulation of interferon-beta production (GO:0032728)2.65802191
157positive regulation of interleukin-1 beta secretion (GO:0050718)2.65710436
158regulation of interleukin-8 biosynthetic process (GO:0045414)2.64582725
159rRNA processing (GO:0006364)2.64096366
160positive regulation of prostaglandin secretion (GO:0032308)2.63781655
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.63781027
162regulation of sister chromatid segregation (GO:0033045)2.63228301
163regulation of mitotic sister chromatid separation (GO:0010965)2.63228301
164regulation of mitotic sister chromatid segregation (GO:0033047)2.63228301
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62913463
166positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62852771
167DNA damage response, detection of DNA damage (GO:0042769)2.62832218
168protein localization to chromosome, centromeric region (GO:0071459)2.62115314
169positive regulation of histone H3-K4 methylation (GO:0051571)2.62111810
170pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61520990
171mitochondrial respiratory chain complex I assembly (GO:0032981)2.60167056
172NADH dehydrogenase complex assembly (GO:0010257)2.60167056
173mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60167056
174interferon-gamma secretion (GO:0072643)2.59321622
175detection of bacterium (GO:0016045)2.59068425
176positive regulation of interferon-alpha production (GO:0032727)2.58347630
177regulation of B cell apoptotic process (GO:0002902)2.58246613
178positive regulation of interleukin-2 production (GO:0032743)2.57599622
179regulation of interleukin-1 beta secretion (GO:0050706)2.57451745
180neutrophil mediated immunity (GO:0002446)2.56304034
181response to interferon-beta (GO:0035456)2.56197333
182fucose catabolic process (GO:0019317)2.54721490
183L-fucose metabolic process (GO:0042354)2.54721490
184L-fucose catabolic process (GO:0042355)2.54721490
185negative regulation of alpha-beta T cell activation (GO:0046636)2.52869523
186regulation of gamma-delta T cell differentiation (GO:0045586)2.52837922
187myeloid leukocyte activation (GO:0002274)2.51780211
188positive regulation of lymphocyte apoptotic process (GO:0070230)2.50388239
189leukocyte degranulation (GO:0043299)2.49892538
190myeloid dendritic cell differentiation (GO:0043011)2.49709363
191branching involved in labyrinthine layer morphogenesis (GO:0060670)2.49473542
192positive regulation of defense response to virus by host (GO:0002230)2.48753130
193leukocyte aggregation (GO:0070486)2.48459899
194myeloid dendritic cell activation (GO:0001773)2.47192604
195detection of external biotic stimulus (GO:0098581)2.47089182
196negative regulation of myeloid cell apoptotic process (GO:0033033)2.47027978
197regulation of heat generation (GO:0031650)2.46109366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93269992
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.13688014
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.60688528
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.59008514
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.03247077
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89401167
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.71928217
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.54238446
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50609185
10* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.40691679
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39515199
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37787915
13* EST1_17652178_ChIP-ChIP_JURKAT_Human3.31130599
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29638779
15* ETS1_20019798_ChIP-Seq_JURKAT_Human3.15190929
16GABP_17652178_ChIP-ChIP_JURKAT_Human3.10036429
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.02069768
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92038883
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.86772675
20CIITA_25753668_ChIP-Seq_RAJI_Human2.83791799
21* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82043623
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62139647
23* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.58094704
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57478465
25* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55623807
26VDR_23849224_ChIP-Seq_CD4+_Human2.54886032
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53366281
28* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52010414
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49732814
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46464404
31* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.44872626
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43907862
33* E2F1_21310950_ChIP-Seq_MCF-7_Human2.32384889
34XRN2_22483619_ChIP-Seq_HELA_Human2.30195083
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.29839114
36* FOXP3_21729870_ChIP-Seq_TREG_Human2.27096757
37TP63_19390658_ChIP-ChIP_HaCaT_Human2.26763349
38VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.20174032
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.18999880
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17927430
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.16716831
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14716677
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14584119
44* GABP_19822575_ChIP-Seq_HepG2_Human2.14418348
45NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12622915
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12283675
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10457732
48* MYB_26560356_Chip-Seq_TH2_Human2.08468374
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99767337
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99515696
51TTF2_22483619_ChIP-Seq_HELA_Human1.97575342
52RUNX_20019798_ChIP-Seq_JUKART_Human1.97082605
53* DCP1A_22483619_ChIP-Seq_HELA_Human1.96813544
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.96472047
55* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.96321132
56ELK1_19687146_ChIP-ChIP_HELA_Human1.96094235
57STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93117910
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92572784
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92179295
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88796852
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87298596
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85594612
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84972554
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82320865
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81308564
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.74814989
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.73178236
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72279797
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70971785
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70751271
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70440138
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70375062
73MAF_26560356_Chip-Seq_TH1_Human1.68521648
74VDR_24763502_ChIP-Seq_THP-1_Human1.67514922
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.66815591
76MYB_26560356_Chip-Seq_TH1_Human1.66589570
77SPI1_23127762_ChIP-Seq_K562_Human1.66231706
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65001582
79* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63366832
80GATA3_26560356_Chip-Seq_TH2_Human1.63008396
81MYC_18940864_ChIP-ChIP_HL60_Human1.61927638
82MAF_26560356_Chip-Seq_TH2_Human1.61473603
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59452839
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58371750
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.56365209
86MYC_22102868_ChIP-Seq_BL_Human1.55532812
87* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54075382
88* GATA3_27048872_Chip-Seq_THYMUS_Human1.52593953
89UTX_26944678_Chip-Seq_JUKART_Human1.51068001
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50833352
91* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.50304531
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50084511
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49474212
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48480401
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.48419179
96* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47254233
97HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46882062
98* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45995207
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43031142
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42687766
101* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41737212
102* BCL6_27268052_Chip-Seq_Bcells_Human1.39763834
103* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38761969
104* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31973091
105* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30762916
106CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30336772
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25410117
108KDM5A_27292631_Chip-Seq_BREAST_Human1.25148342
109* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25050279
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24766795
111STAT1_20625510_ChIP-Seq_HELA_Human1.18716607
112* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18602818
113BCOR_27268052_Chip-Seq_Bcells_Human1.17584530
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17544721
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16971592
116ELF1_20517297_ChIP-Seq_JURKAT_Human1.15671339
117PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15583145
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15102127
119* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13755692
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13707918
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10742337
122BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09831655
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08085392
124TFEB_21752829_ChIP-Seq_HELA_Human1.06810127
125FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06468845
126IRF1_19129219_ChIP-ChIP_H3396_Human1.05802853
127VDR_24787735_ChIP-Seq_THP-1_Human1.04463642
128* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03798744
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02767231
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02665454
131* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00951229
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00530715
133GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00140518
134VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98909125
135* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97993404
136AR_21909140_ChIP-Seq_LNCAP_Human0.97775380
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96782400
138* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96042743
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.96009603
140PU_27001747_Chip-Seq_BMDM_Mouse0.95792921
141* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95314682
142* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92863956
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92603891
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91462342
145PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91023373
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90964017
147ZNF274_21170338_ChIP-Seq_K562_Hela0.89381855
148P300_27268052_Chip-Seq_Bcells_Human0.88341433
149RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88235625
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88168667
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.87510095
152* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87448860
153SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87364606
154PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86924237
155* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86114056
156ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85026110
157* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84533640
158SOX2_16153702_ChIP-ChIP_HESCs_Human0.77770760
159SPI1_23547873_ChIP-Seq_NB4_Human0.76975971
160VDR_21846776_ChIP-Seq_THP-1_Human0.76731410
161* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72725189
162* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72338890
163EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67976519
164GATA1_22025678_ChIP-Seq_K562_Human0.67303299
165SCL_19346495_ChIP-Seq_HPC-7_Human0.65741498

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.41023741
2MP0003303_peritoneal_inflammation4.13574674
3MP0008057_abnormal_DNA_replication3.96070312
4MP0010094_abnormal_chromosome_stability3.81997811
5MP0003724_increased_susceptibility_to3.74176158
6MP0006292_abnormal_olfactory_placode3.49797416
7MP0003111_abnormal_nucleus_morphology3.42417376
8MP0004957_abnormal_blastocyst_morpholog3.32085834
9MP0008007_abnormal_cellular_replicative3.29595996
10MP0003436_decreased_susceptibility_to3.27846648
11MP0003077_abnormal_cell_cycle3.19534352
12MP0002148_abnormal_hypersensitivity_rea3.11926918
13MP0005671_abnormal_response_to2.94344940
14MP0009785_altered_susceptibility_to2.91536294
15MP0001835_abnormal_antigen_presentation2.89999310
16MP0006082_CNS_inflammation2.89518270
17MP0000678_abnormal_parathyroid_gland2.80790238
18MP0005000_abnormal_immune_tolerance2.73590468
19MP0008877_abnormal_DNA_methylation2.69256289
20MP0008058_abnormal_DNA_repair2.61860137
21MP0001800_abnormal_humoral_immune2.61365111
22MP0008961_abnormal_basal_metabolism2.60086728
23MP0003806_abnormal_nucleotide_metabolis2.57125673
24MP0002419_abnormal_innate_immunity2.56134623
25MP0009764_decreased_sensitivity_to2.55914504
26MP0001188_hyperpigmentation2.48269218
27MP0002723_abnormal_immune_serum2.46772825
28MP0005025_abnormal_response_to2.46049995
29MP0002452_abnormal_antigen_presenting2.35972165
30MP0001790_abnormal_immune_system2.30094974
31MP0005387_immune_system_phenotype2.30094974
32MP0001819_abnormal_immune_cell2.15854165
33MP0002420_abnormal_adaptive_immunity2.15491802
34MP0006072_abnormal_retinal_apoptosis2.15104540
35MP0008932_abnormal_embryonic_tissue2.12329421
36MP0003787_abnormal_imprinting2.05912133
37MP0009278_abnormal_bone_marrow1.99979443
38MP0003123_paternal_imprinting1.96394115
39MP0002396_abnormal_hematopoietic_system1.93318223
40MP0001545_abnormal_hematopoietic_system1.91191115
41MP0005397_hematopoietic_system_phenotyp1.91191115
42MP0003315_abnormal_perineum_morphology1.88534842
43MP0000015_abnormal_ear_pigmentation1.83019601
44MP0002405_respiratory_system_inflammati1.82838095
45MP0000685_abnormal_immune_system1.78504263
46MP0001533_abnormal_skeleton_physiology1.78246980
47MP0003121_genomic_imprinting1.76513292
48MP0001845_abnormal_inflammatory_respons1.75252983
49MP0009379_abnormal_foot_pigmentation1.72624174
50MP0002254_reproductive_system_inflammat1.70604726
51MP0004510_myositis1.70326759
52MP0003718_maternal_effect1.66119780
53MP0000716_abnormal_immune_system1.64769716
54MP0005058_abnormal_lysosome_morphology1.64754876
55MP0001986_abnormal_taste_sensitivity1.62153630
56MP0003075_altered_response_to1.59610279
57MP0005174_abnormal_tail_pigmentation1.59515427
58MP0003646_muscle_fatigue1.58911433
59MP0005409_darkened_coat_color1.57945062
60MP0008469_abnormal_protein_level1.57866606
61MP0004947_skin_inflammation1.56897803
62MP0000350_abnormal_cell_proliferation1.54641572
63MP0003786_premature_aging1.52950576
64MP0010155_abnormal_intestine_physiology1.50671994
65MP0002139_abnormal_hepatobiliary_system1.45906900
66MP0002693_abnormal_pancreas_physiology1.45877214
67MP0003172_abnormal_lysosome_physiology1.44021655
68MP0005410_abnormal_fertilization1.41030342
69MP0008004_abnormal_stomach_pH1.40903918
70MP0005310_abnormal_salivary_gland1.39424333
71MP0004808_abnormal_hematopoietic_stem1.38318250
72MP0010307_abnormal_tumor_latency1.38104655
73MP0002938_white_spotting1.37989124
74MP0002210_abnormal_sex_determination1.37227334
75MP0009840_abnormal_foam_cell1.35890940
76MP0001730_embryonic_growth_arrest1.31987276
77MP0001929_abnormal_gametogenesis1.30239721
78MP0003195_calcinosis1.30044346
79MP0002877_abnormal_melanocyte_morpholog1.29386072
80MP0002332_abnormal_exercise_endurance1.28815226
81MP0002429_abnormal_blood_cell1.28552229
82MP0001697_abnormal_embryo_size1.27147828
83MP0002653_abnormal_ependyma_morphology1.26871769
84MP0003300_gastrointestinal_ulcer1.25947886
85MP0001944_abnormal_pancreas_morphology1.25368155
86MP0005379_endocrine/exocrine_gland_phen1.23986945
87MP0002085_abnormal_embryonic_tissue1.23627845
88MP0000703_abnormal_thymus_morphology1.22295208
89MP0002638_abnormal_pupillary_reflex1.21256724
90MP0010386_abnormal_urinary_bladder1.20164720
91MP0000013_abnormal_adipose_tissue1.18341909
92MP0003890_abnormal_embryonic-extraembry1.16215472
93MP0000653_abnormal_sex_gland1.14180636
94MP0002132_abnormal_respiratory_system1.13113407
95MP0000313_abnormal_cell_death1.12548909
96MP0001145_abnormal_male_reproductive1.11087268
97MP0005167_abnormal_blood-brain_barrier1.10828689
98MP0002095_abnormal_skin_pigmentation1.10626988
99MP0005451_abnormal_body_composition1.09965017
100MP0002751_abnormal_autonomic_nervous1.09830503
101MP0001851_eye_inflammation1.08814908
102MP0003763_abnormal_thymus_physiology1.08810838
103MP0000049_abnormal_middle_ear1.07412266
104MP0001873_stomach_inflammation1.06067243
105MP0005464_abnormal_platelet_physiology1.05272601
106MP0002127_abnormal_cardiovascular_syste1.05268082
107MP0003448_altered_tumor_morphology1.04637815
108MP0002019_abnormal_tumor_incidence1.02316874
109MP0005380_embryogenesis_phenotype1.01275176
110MP0001672_abnormal_embryogenesis/_devel1.01275176
111MP0002080_prenatal_lethality1.01208487
112MP0005220_abnormal_exocrine_pancreas1.00096855
113MP0000343_altered_response_to0.98589876
114MP0000631_abnormal_neuroendocrine_gland0.98583986
115MP0001853_heart_inflammation0.97708684
116MP0002234_abnormal_pharynx_morphology0.97378391
117MP0002084_abnormal_developmental_patter0.96629584
118MP0003283_abnormal_digestive_organ0.95946359
119MP0005367_renal/urinary_system_phenotyp0.93822279
120MP0000516_abnormal_urinary_system0.93822279
121MP0006054_spinal_hemorrhage0.92798507
122MP0000462_abnormal_digestive_system0.92589052
123MP0002177_abnormal_outer_ear0.92015029
124MP0000613_abnormal_salivary_gland0.91977807
125MP0003119_abnormal_digestive_system0.91379493
126MP0001119_abnormal_female_reproductive0.91359478
127MP0001663_abnormal_digestive_system0.91301920
128MP0001919_abnormal_reproductive_system0.90834178
129MP0002160_abnormal_reproductive_system0.90712584
130MP0009333_abnormal_splenocyte_physiolog0.89274893
131MP0002163_abnormal_gland_morphology0.88792241
132MP0002398_abnormal_bone_marrow0.88443856
133MP0005389_reproductive_system_phenotype0.87014818
134MP0002138_abnormal_hepatobiliary_system0.86804131
135MP0002102_abnormal_ear_morphology0.86540243
136MP0005365_abnormal_bile_salt0.86042735
137MP0003699_abnormal_female_reproductive0.85140820
138MP0002277_abnormal_respiratory_mucosa0.82734327
139MP0005646_abnormal_pituitary_gland0.81436729
140MP0005166_decreased_susceptibility_to0.81162853
141MP0004145_abnormal_muscle_electrophysio0.79241927
142MP0000490_abnormal_crypts_of0.78770707
143MP0003122_maternal_imprinting0.78461032
144MP0003984_embryonic_growth_retardation0.77974393
145MP0009765_abnormal_xenobiotic_induced0.76786498
146MP0002928_abnormal_bile_duct0.76513603
147MP0000681_abnormal_thyroid_gland0.76036799
148MP0002722_abnormal_immune_system0.74596317
149MP0004043_abnormal_pH_regulation0.74423549
150MP0002088_abnormal_embryonic_growth/wei0.74384510
151MP0002998_abnormal_bone_remodeling0.74097660
152MP0003656_abnormal_erythrocyte_physiolo0.73724513
153MP0009115_abnormal_fat_cell0.73702414
154MP0005319_abnormal_enzyme/_coenzyme0.73606920
155MP0006035_abnormal_mitochondrial_morpho0.72112566
156MP0000609_abnormal_liver_physiology0.72107760
157MP0000858_altered_metastatic_potential0.70846883
158MP0002161_abnormal_fertility/fecundity0.70550644
159MP0005390_skeleton_phenotype0.70450904
160MP0005266_abnormal_metabolism0.69848194
161MP0000689_abnormal_spleen_morphology0.69775992
162MP0000465_gastrointestinal_hemorrhage0.69701617
163MP0000428_abnormal_craniofacial_morphol0.69675936
164MP0001764_abnormal_homeostasis0.69625880
165MP0003937_abnormal_limbs/digits/tail_de0.69476486
166MP0005384_cellular_phenotype0.69440128
167MP0009763_increased_sensitivity_to0.69327371
168MP0002249_abnormal_larynx_morphology0.69241435
169MP0005647_abnormal_sex_gland0.68717435
170MP0003879_abnormal_hair_cell0.68693784
171MP0000604_amyloidosis0.68595715
172MP0009672_abnormal_birth_weight0.67164019
173MP0002909_abnormal_adrenal_gland0.66432858
174MP0003866_abnormal_defecation0.66391688
175MP0000358_abnormal_cell_content/0.66027090
176MP0003861_abnormal_nervous_system0.65868399
177MP0002114_abnormal_axial_skeleton0.65719025
178MP0008789_abnormal_olfactory_epithelium0.65017102
179MP0008873_increased_physiological_sensi0.63407667
180MP0005334_abnormal_fat_pad0.60726292
181MP0005248_abnormal_Harderian_gland0.59350652
182MP0003183_abnormal_peptide_metabolism0.56429438

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)4.76094632
2Birth length less than 3rd percentile (HP:0003561)4.51790475
3Retrobulbar optic neuritis (HP:0100654)4.44811956
4Optic neuritis (HP:0100653)4.44811956
5Myositis (HP:0100614)4.35920549
6Stomatitis (HP:0010280)4.32042866
7Orchitis (HP:0100796)4.28007220
8Medulloblastoma (HP:0002885)4.16707615
9Progressive macrocephaly (HP:0004481)3.96460984
10Recurrent bacterial skin infections (HP:0005406)3.85992663
11Acute encephalopathy (HP:0006846)3.84316701
12Aplastic anemia (HP:0001915)3.73736322
13Abnormality of liposaccharide metabolism (HP:0010968)3.67502951
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.67502951
15Abnormality of glycolipid metabolism (HP:0010969)3.67502951
16Recurrent abscess formation (HP:0002722)3.60838497
17Rhabdomyosarcoma (HP:0002859)3.52263371
18Increased cerebral lipofuscin (HP:0011813)3.45706803
19Abnormality of macrophages (HP:0004311)3.38561449
20Keratoconjunctivitis (HP:0001096)3.36628364
21Chromsome breakage (HP:0040012)3.32789219
22Keratoconjunctivitis sicca (HP:0001097)3.30764862
23Pancreatic fibrosis (HP:0100732)3.28981894
24Increased neuronal autofluorescent lipopigment (HP:0002074)3.28381929
25Patellar aplasia (HP:0006443)3.22359824
26Elevated erythrocyte sedimentation rate (HP:0003565)3.21352857
27Dyschromatopsia (HP:0007641)3.18961934
28Pancreatic cysts (HP:0001737)3.09924360
29Aplasia/Hypoplasia of the patella (HP:0006498)3.08683156
30Mediastinal lymphadenopathy (HP:0100721)3.08559651
31Eczematoid dermatitis (HP:0000976)3.04087938
32Reticulocytopenia (HP:0001896)3.01665030
3311 pairs of ribs (HP:0000878)2.99036225
34Abnormality of the heme biosynthetic pathway (HP:0010472)2.98297496
35Cerebral edema (HP:0002181)2.98180648
36Meckel diverticulum (HP:0002245)2.94932176
37Abnormality of the preputium (HP:0100587)2.93391297
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92913687
39Autoimmune thrombocytopenia (HP:0001973)2.87867650
40Breast hypoplasia (HP:0003187)2.87446512
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.87237746
42True hermaphroditism (HP:0010459)2.86515072
43Abnormality of the pleura (HP:0002103)2.83717274
44Recurrent fungal infections (HP:0002841)2.82317429
45Abnormality of the ileum (HP:0001549)2.77162310
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.74955844
47CNS demyelination (HP:0007305)2.72176141
48Abnormal number of erythroid precursors (HP:0012131)2.70946613
49Acute lymphatic leukemia (HP:0006721)2.70363758
50Abnormality of cells of the erythroid lineage (HP:0012130)2.68877249
51Abnormality of DNA repair (HP:0003254)2.68158170
52Emotional lability (HP:0000712)2.64257212
53Rough bone trabeculation (HP:0100670)2.63763746
54Abnormality of chromosome stability (HP:0003220)2.62213340
55Horseshoe kidney (HP:0000085)2.61863762
56Encephalitis (HP:0002383)2.60627556
57Increased IgM level (HP:0003496)2.58571291
58Abnormal biliary tract physiology (HP:0012439)2.56045070
59Bile duct proliferation (HP:0001408)2.56045070
60Chronic obstructive pulmonary disease (HP:0006510)2.55415089
61Obstructive lung disease (HP:0006536)2.55415089
62Myelodysplasia (HP:0002863)2.54973963
63Neoplasm of striated muscle (HP:0009728)2.53862142
64Recurrent gram-negative bacterial infections (HP:0005420)2.51153483
65Pallor (HP:0000980)2.46930815
66Vacuolated lymphocytes (HP:0001922)2.46907458
67Vasculitis (HP:0002633)2.43952049
68Recurrent skin infections (HP:0001581)2.41825463
69Disinhibition (HP:0000734)2.41306561
70Abnormality of midbrain morphology (HP:0002418)2.41103852
71Molar tooth sign on MRI (HP:0002419)2.41103852
72Gliosis (HP:0002171)2.39756481
73Gangrene (HP:0100758)2.39356317
74Cerebral hypomyelination (HP:0006808)2.38264264
75Bone marrow hypocellularity (HP:0005528)2.38150908
76Acute necrotizing encephalopathy (HP:0006965)2.36890222
77Severe visual impairment (HP:0001141)2.36872325
78Nephronophthisis (HP:0000090)2.34155369
79Type 2 muscle fiber atrophy (HP:0003554)2.31938501
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30017505
81Oral leukoplakia (HP:0002745)2.28983331
82T lymphocytopenia (HP:0005403)2.28551277
83Abnormality of T cell number (HP:0011839)2.27751379
84Mitochondrial inheritance (HP:0001427)2.26277031
85Pulmonary infiltrates (HP:0002113)2.26121679
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.25977649
87Leukocytosis (HP:0001974)2.25964847
88Colon cancer (HP:0003003)2.24764809
89Premature graying of hair (HP:0002216)2.24400101
90Recurrent cutaneous fungal infections (HP:0011370)2.24175294
91Chronic mucocutaneous candidiasis (HP:0002728)2.24175294
92Muscle fiber atrophy (HP:0100295)2.23011038
93Small intestinal stenosis (HP:0012848)2.22597540
94Duodenal stenosis (HP:0100867)2.22597540
95Optic nerve coloboma (HP:0000588)2.22149122
96Meningitis (HP:0001287)2.21967021
97IgG deficiency (HP:0004315)2.21525675
98Abnormal rod and cone electroretinograms (HP:0008323)2.16961175
99Hemoptysis (HP:0002105)2.15786863
100Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14751791
101Sloping forehead (HP:0000340)2.14591682
102Unsteady gait (HP:0002317)2.14537041
103Abnormal trabecular bone morphology (HP:0100671)2.14035472
104Prostate neoplasm (HP:0100787)2.13965839
105Fatigue (HP:0012378)2.13743790
106Increased serum ferritin (HP:0003281)2.13465138
107Dysostosis multiplex (HP:0000943)2.13349233
108Secondary amenorrhea (HP:0000869)2.11638686
109Chronic bronchitis (HP:0004469)2.11136266
110Respiratory failure (HP:0002878)2.10913839
111Facial cleft (HP:0002006)2.10809016
112Loss of speech (HP:0002371)2.10648066
113Type I transferrin isoform profile (HP:0003642)2.09731107
114Agnosia (HP:0010524)2.09292023
115Short 4th metacarpal (HP:0010044)2.07979119
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.07979119
117Absent thumb (HP:0009777)2.06955064
118Optic disc pallor (HP:0000543)2.06209417
119Deep palmar crease (HP:0006191)2.05265880
120Prominent metopic ridge (HP:0005487)2.03689346
121Abnormal mitochondria in muscle tissue (HP:0008316)2.03559764
122Arterial thrombosis (HP:0004420)2.01314939
123Neoplasm of the pancreas (HP:0002894)2.01275644
124Pustule (HP:0200039)2.00727306
125Decreased circulating renin level (HP:0003351)1.99875092
126Anorexia (HP:0002039)1.97916183
127Recurrent viral infections (HP:0004429)1.97218061
128Asplenia (HP:0001746)1.97087826
129Papillary thyroid carcinoma (HP:0002895)1.96622893
130Keratitis (HP:0000491)1.95717781
131Aplasia/hypoplasia of the uterus (HP:0008684)1.95146082
132Lymphopenia (HP:0001888)1.94923799
133Abnormality of the duodenum (HP:0002246)1.94689342
134Clubbing of toes (HP:0100760)1.94048750
135Increased CSF lactate (HP:0002490)1.92223353
136Increased serum lactate (HP:0002151)1.92076198
137Cystic liver disease (HP:0006706)1.92009106
138Abnormality of lateral ventricle (HP:0030047)1.91574013
139Abnormality of the carotid arteries (HP:0005344)1.91087076
140Anencephaly (HP:0002323)1.90150070
141Basal cell carcinoma (HP:0002671)1.90040901
142Occipital encephalocele (HP:0002085)1.89976997
143Carpal bone hypoplasia (HP:0001498)1.89651199
144Abnormality of transition element cation homeostasis (HP:0011030)1.88986295
145Petechiae (HP:0000967)1.88249834
146Macrocytic anemia (HP:0001972)1.87113016
147Abnormality of the labia minora (HP:0012880)1.86688620
148Abnormality of the pericardium (HP:0001697)1.85747426
149Gastrointestinal infarctions (HP:0005244)1.84277375
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83215617
151Abnormality of polysaccharide metabolism (HP:0011012)1.83156861
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83156861
153Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83156861
154Abnormality of iron homeostasis (HP:0011031)1.83064464
155Abnormal drinking behavior (HP:0030082)1.82821224
156Polydipsia (HP:0001959)1.82821224
157Entropion (HP:0000621)1.82588848
158IgA deficiency (HP:0002720)1.82111105
159Abnormality of the metopic suture (HP:0005556)1.81489722
160Abnormality of B cell number (HP:0010975)1.81470602
161Eosinophilia (HP:0001880)1.81299342
162Aplasia/Hypoplasia of the spleen (HP:0010451)1.80492989
163Pancytopenia (HP:0001876)1.80475414
1643-Methylglutaconic aciduria (HP:0003535)1.79996954
165Hepatocellular necrosis (HP:0001404)1.78801932
166Autoimmune hemolytic anemia (HP:0001890)1.77313780
167Parakeratosis (HP:0001036)1.77311632
168Neoplasm of the tracheobronchial system (HP:0100552)1.77267953
169Leukodystrophy (HP:0002415)1.76392128
170Triphalangeal thumb (HP:0001199)1.74801098
171Abnormality of the anterior horn cell (HP:0006802)1.73610466
172Degeneration of anterior horn cells (HP:0002398)1.73610466
173Missing ribs (HP:0000921)1.73417794
174Abnormal protein glycosylation (HP:0012346)1.73106272
175Abnormal glycosylation (HP:0012345)1.73106272
176Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73106272
177Abnormal protein N-linked glycosylation (HP:0012347)1.73106272
178Microretrognathia (HP:0000308)1.72273594
179Granulocytopenia (HP:0001913)1.72273481
180Abnormal number of incisors (HP:0011064)1.71566560
181Insulin-resistant diabetes mellitus (HP:0000831)1.71307889
182Depressed nasal ridge (HP:0000457)1.70335318
183Preaxial hand polydactyly (HP:0001177)1.69478398
184Shawl scrotum (HP:0000049)1.68884212
185Cellular immunodeficiency (HP:0005374)1.66233062
186Attenuation of retinal blood vessels (HP:0007843)1.66072747
187Abnormality of the columella (HP:0009929)1.65967299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.30603163
2BUB14.05555897
3TLK13.61651358
4CDC73.04872213
5MKNK23.01841730
6MAP3K112.78520325
7MAP3K142.71146841
8PASK2.69532782
9WEE12.48846573
10TBK12.41996224
11BLK2.23986077
12TAOK32.23781122
13NEK22.17714602
14IKBKE2.17291692
15SRPK12.16102489
16GRK72.11253302
17IKBKB2.10048921
18RIPK12.07444912
19VRK12.06482212
20RIPK42.06426343
21MAP2K32.05353897
22CDK81.98801022
23BMPR21.96077195
24MATK1.93866665
25TTK1.90191732
26TAOK21.88816683
27MKNK11.85150008
28MARK31.83504265
29ACVR1B1.74511538
30PLK41.72766794
31PLK11.71713283
32CASK1.68072658
33TAOK11.65962529
34BRAF1.62202897
35CSK1.54534348
36TNK21.51501002
37TYK21.50435735
38NME21.46982907
39TSSK61.40976680
40FGR1.40888594
41BRSK21.39340111
42GRK61.36974039
43JAK31.35364666
44MAP4K11.32808892
45MAP3K31.31448288
46MUSK1.29269162
47CCNB11.28718600
48ATR1.27502052
49VRK21.26626588
50DYRK31.24550773
51CDK191.23734892
52NME11.23535040
53PIM21.23008441
54IRAK21.21113625
55PNCK1.20613831
56AURKB1.19519089
57FLT31.19093723
58PIM11.17249394
59HIPK21.16598598
60CHEK21.15757931
61MAP3K131.14622109
62ZAK1.11489861
63MAPK131.11456482
64BRD41.09905273
65CDK71.07719604
66TNIK1.05796857
67BRSK11.05187404
68EIF2AK11.03568451
69CDK91.03323371
70MOS1.02598723
71CDK121.01963080
72PLK30.99694933
73NTRK30.97261378
74AURKA0.96400103
75CHUK0.95409317
76HCK0.92221986
77MAP4K20.90924161
78CHEK10.90356379
79NUAK10.89535387
80MAP3K10.89041895
81AKT30.88546286
82TESK20.88356656
83PINK10.87977903
84LCK0.86977824
85ATM0.84615544
86TXK0.84275607
87CDK30.83804402
88INSRR0.83015248
89FRK0.80622759
90MAP2K60.79501989
91ZAP700.79447843
92EIF2AK30.76743928
93CDK20.75531686
94LATS10.72984188
95CDK40.71764230
96BMPR1B0.70980751
97TGFBR20.70577090
98TGFBR10.68485110
99CSF1R0.68241589
100KIT0.67095884
101IRAK40.66882987
102PRKD20.66010586
103PRKCQ0.65537135
104KDR0.65423509
105MAP3K50.64405038
106PRKCI0.63377733
107BCKDK0.63191575
108MELK0.62896970
109LATS20.61357749
110ITK0.60901718
111EPHA30.59326629
112CSNK2A20.59238533
113CLK10.59023668
114CDK10.55923474
115RPS6KA60.55524001
116MAP2K70.55435810
117JAK20.55025218
118BTK0.54840130
119RPS6KA40.54051756
120DYRK20.53871632
121CSNK2A10.53098702
122RPS6KA50.53070386
123DDR20.51748896
124MAP3K60.51194020
125ERN10.48294171
126MARK20.45873215
127RPS6KL10.43945412
128RPS6KC10.43945412
129RPS6KB20.42341134
130IRAK10.42331248
131IRAK30.42323060
132WNK40.42155080
133PRKDC0.41918460
134PKN10.41894208
135NLK0.41858127
136SIK20.40889373
137YES10.40117397
138RPS6KA10.40108256
139FES0.40043773
140MAP3K40.38979362
141MAPK140.38830423
142DYRK1A0.37679568
143MAP3K20.37274903
144PLK20.34635688
145CSNK1E0.32694608
146AKT10.32429372
147DAPK10.32323410
148GSK3B0.31913559
149STK100.31476118
150TEC0.31458776
151GRK10.30773819
152ADRBK20.30247452
153PRKCZ0.30204164
154STK38L0.28034854
155STK390.27758780
156MAP2K40.27632504
157STK40.27141845
158BMX0.26401278
159EPHA20.26171322
160EEF2K0.25960167
161CDC42BPA0.25764150
162MAP3K100.25565770
163LYN0.24208874
164MAPK110.22912456
165EIF2AK20.22282373
166SYK0.21714076
167MAP3K80.21677096

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.06090765
2DNA replication_Homo sapiens_hsa030303.75808269
3RNA polymerase_Homo sapiens_hsa030203.38724721
4Protein export_Homo sapiens_hsa030603.07022878
5Homologous recombination_Homo sapiens_hsa034403.00178441
6Ribosome_Homo sapiens_hsa030102.98716816
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84765206
8Allograft rejection_Homo sapiens_hsa053302.82661676
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.71417612
10Spliceosome_Homo sapiens_hsa030402.68129532
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.64064532
12Graft-versus-host disease_Homo sapiens_hsa053322.63321661
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.59054543
14Base excision repair_Homo sapiens_hsa034102.50617646
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.49980778
16Asthma_Homo sapiens_hsa053102.49059834
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.48794399
18Fanconi anemia pathway_Homo sapiens_hsa034602.45885943
19Nucleotide excision repair_Homo sapiens_hsa034202.44979143
20RNA transport_Homo sapiens_hsa030132.42577814
21Leishmaniasis_Homo sapiens_hsa051402.41066903
22Cell cycle_Homo sapiens_hsa041102.40606718
23Osteoclast differentiation_Homo sapiens_hsa043802.40045942
24Staphylococcus aureus infection_Homo sapiens_hsa051502.30969080
25Rheumatoid arthritis_Homo sapiens_hsa053232.29694542
26Autoimmune thyroid disease_Homo sapiens_hsa053202.29000408
27Basal transcription factors_Homo sapiens_hsa030222.25917037
28Non-homologous end-joining_Homo sapiens_hsa034502.24059505
29RNA degradation_Homo sapiens_hsa030182.17544649
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14778971
31Pyrimidine metabolism_Homo sapiens_hsa002402.14265520
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10219455
33Legionellosis_Homo sapiens_hsa051342.02172514
34TNF signaling pathway_Homo sapiens_hsa046681.95304871
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93301562
36Type I diabetes mellitus_Homo sapiens_hsa049401.87644017
37Malaria_Homo sapiens_hsa051441.81855667
38Tuberculosis_Homo sapiens_hsa051521.79750516
39Proteasome_Homo sapiens_hsa030501.69274571
40One carbon pool by folate_Homo sapiens_hsa006701.68916136
41mRNA surveillance pathway_Homo sapiens_hsa030151.65042865
42African trypanosomiasis_Homo sapiens_hsa051431.60517111
43Lysosome_Homo sapiens_hsa041421.47831779
44Influenza A_Homo sapiens_hsa051641.47366501
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45346203
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42321636
47Pertussis_Homo sapiens_hsa051331.35128525
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32890362
49Oocyte meiosis_Homo sapiens_hsa041141.32127092
50Purine metabolism_Homo sapiens_hsa002301.31517364
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31276410
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.24661924
53Salmonella infection_Homo sapiens_hsa051321.19864017
54Toxoplasmosis_Homo sapiens_hsa051451.19702732
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17707939
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.16583333
57p53 signaling pathway_Homo sapiens_hsa041151.16229783
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14500463
59B cell receptor signaling pathway_Homo sapiens_hsa046621.14409897
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13830404
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08544744
62T cell receptor signaling pathway_Homo sapiens_hsa046601.05784753
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01211377
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99240223
65Chemokine signaling pathway_Homo sapiens_hsa040620.99012127
66Epstein-Barr virus infection_Homo sapiens_hsa051690.97944557
67Systemic lupus erythematosus_Homo sapiens_hsa053220.97276989
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94112331
69Insulin secretion_Homo sapiens_hsa049110.91769025
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86699868
71Acute myeloid leukemia_Homo sapiens_hsa052210.84938510
72Hepatitis C_Homo sapiens_hsa051600.84162165
73Viral myocarditis_Homo sapiens_hsa054160.82787755
74Folate biosynthesis_Homo sapiens_hsa007900.81576069
75Apoptosis_Homo sapiens_hsa042100.78050224
76Alcoholism_Homo sapiens_hsa050340.77856998
77N-Glycan biosynthesis_Homo sapiens_hsa005100.76364769
78Phagosome_Homo sapiens_hsa041450.75671446
79Circadian rhythm_Homo sapiens_hsa047100.71437575
80Huntingtons disease_Homo sapiens_hsa050160.69650078
81Other glycan degradation_Homo sapiens_hsa005110.67613349
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64476319
83Vibrio cholerae infection_Homo sapiens_hsa051100.64064925
84Shigellosis_Homo sapiens_hsa051310.61580633
85Taste transduction_Homo sapiens_hsa047420.61231338
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60387857
87Herpes simplex infection_Homo sapiens_hsa051680.59096336
88Primary immunodeficiency_Homo sapiens_hsa053400.58113500
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57656289
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56160282
91Thyroid cancer_Homo sapiens_hsa052160.55562165
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55537532
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55462657
94HTLV-I infection_Homo sapiens_hsa051660.55298241
95Long-term potentiation_Homo sapiens_hsa047200.54010122
96Nicotine addiction_Homo sapiens_hsa050330.53299014
97Notch signaling pathway_Homo sapiens_hsa043300.53260724
98Viral carcinogenesis_Homo sapiens_hsa052030.53020250
99Antigen processing and presentation_Homo sapiens_hsa046120.52775936
100Collecting duct acid secretion_Homo sapiens_hsa049660.51346623
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51154950
102Long-term depression_Homo sapiens_hsa047300.50225332
103Dorso-ventral axis formation_Homo sapiens_hsa043200.49368896
104Oxidative phosphorylation_Homo sapiens_hsa001900.49235346
105MicroRNAs in cancer_Homo sapiens_hsa052060.48419151
106Amphetamine addiction_Homo sapiens_hsa050310.45138426
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45108886
108Phototransduction_Homo sapiens_hsa047440.43617980
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.42977820
110Hematopoietic cell lineage_Homo sapiens_hsa046400.41432185
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40791950
112Wnt signaling pathway_Homo sapiens_hsa043100.40697540
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40295556
114Parkinsons disease_Homo sapiens_hsa050120.39678822
115Tryptophan metabolism_Homo sapiens_hsa003800.35421814
116Synaptic vesicle cycle_Homo sapiens_hsa047210.35260458
117Regulation of autophagy_Homo sapiens_hsa041400.35105904
118Circadian entrainment_Homo sapiens_hsa047130.31851680
119Hepatitis B_Homo sapiens_hsa051610.30332804
120Olfactory transduction_Homo sapiens_hsa047400.30315981
121Selenocompound metabolism_Homo sapiens_hsa004500.30127106
122Dopaminergic synapse_Homo sapiens_hsa047280.30006914
123TGF-beta signaling pathway_Homo sapiens_hsa043500.29313196
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.28910571
125Sulfur relay system_Homo sapiens_hsa041220.28236755
126Alzheimers disease_Homo sapiens_hsa050100.28064203
127Colorectal cancer_Homo sapiens_hsa052100.27215189
128Ovarian steroidogenesis_Homo sapiens_hsa049130.26994184
129Sphingolipid metabolism_Homo sapiens_hsa006000.26680060
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26392836
131Prolactin signaling pathway_Homo sapiens_hsa049170.25447971
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25114864
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24566777
134Arachidonic acid metabolism_Homo sapiens_hsa005900.23823167
135Serotonergic synapse_Homo sapiens_hsa047260.23677541
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23182722
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23071877
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.23034581
139Fructose and mannose metabolism_Homo sapiens_hsa000510.23007837
140FoxO signaling pathway_Homo sapiens_hsa040680.22624297
141Glutamatergic synapse_Homo sapiens_hsa047240.22279695
142Measles_Homo sapiens_hsa051620.21786131
143Bladder cancer_Homo sapiens_hsa052190.20684593
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.20553438
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20331105
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20225968
147Lysine degradation_Homo sapiens_hsa003100.19741170
148GnRH signaling pathway_Homo sapiens_hsa049120.17632998
149Hedgehog signaling pathway_Homo sapiens_hsa043400.14990343
150Morphine addiction_Homo sapiens_hsa050320.13996910
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13693461
152Melanogenesis_Homo sapiens_hsa049160.12728698
153Cocaine addiction_Homo sapiens_hsa050300.12569260
154Chronic myeloid leukemia_Homo sapiens_hsa052200.12473355
155MAPK signaling pathway_Homo sapiens_hsa040100.12299689

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