BAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of membrane potential (GO:0045837)7.22442796
2water-soluble vitamin biosynthetic process (GO:0042364)6.80390614
3positive regulation of endothelial cell differentiation (GO:0045603)6.75706585
4positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.66451034
5negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)6.42106930
6regulation of fatty acid beta-oxidation (GO:0031998)6.31079548
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.07432438
8negative regulation of DNA-templated transcription, elongation (GO:0032785)6.05570251
9base-excision repair, AP site formation (GO:0006285)5.80684274
10misfolded or incompletely synthesized protein catabolic process (GO:0006515)5.48548408
11regulation of mitochondrial translation (GO:0070129)5.35936860
12response to gravity (GO:0009629)5.34007419
13protein import into peroxisome matrix (GO:0016558)5.28569950
14pyrimidine nucleotide catabolic process (GO:0006244)5.21188375
15serotonin metabolic process (GO:0042428)4.91577062
16angiogenesis involved in wound healing (GO:0060055)4.89521188
17positive regulation of fatty acid beta-oxidation (GO:0032000)4.87897707
18negative regulation of erythrocyte differentiation (GO:0045647)4.74989426
19regulation of endothelial cell differentiation (GO:0045601)4.67213564
20positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.64885898
21tooth mineralization (GO:0034505)4.56596920
22kidney mesenchyme development (GO:0072074)4.56336817
23embryonic skeletal joint morphogenesis (GO:0060272)4.43072296
24primary amino compound metabolic process (GO:1901160)4.36816264
25peptidyl-arginine omega-N-methylation (GO:0035247)4.33566383
26layer formation in cerebral cortex (GO:0021819)4.25201395
27positive regulation of synapse maturation (GO:0090129)4.12288250
28behavioral response to nicotine (GO:0035095)4.06654632
29peptidyl-lysine dimethylation (GO:0018027)4.02120752
30cobalamin metabolic process (GO:0009235)4.01154196
31synaptic vesicle maturation (GO:0016188)3.99701523
32pre-miRNA processing (GO:0031054)3.98270563
33positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97473862
34peptidyl-arginine methylation (GO:0018216)3.97095073
35peptidyl-arginine N-methylation (GO:0035246)3.97095073
36locomotory exploration behavior (GO:0035641)3.96142936
37metanephric mesenchyme development (GO:0072075)3.88394918
38regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.88169680
39protein complex biogenesis (GO:0070271)3.80295980
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.76303399
41phosphatidylethanolamine biosynthetic process (GO:0006646)3.76282859
42regulation of NFAT protein import into nucleus (GO:0051532)3.73672381
43middle ear morphogenesis (GO:0042474)3.73201548
44negative regulation of dendrite morphogenesis (GO:0050774)3.72059365
45DNA unwinding involved in DNA replication (GO:0006268)3.71237927
46negative regulation of microtubule polymerization (GO:0031115)3.69483350
47cerebellar Purkinje cell layer development (GO:0021680)3.65488388
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.63725281
49regulation of translational termination (GO:0006449)3.62620834
50pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.55689282
51histone arginine methylation (GO:0034969)3.55471459
52actin filament polymerization (GO:0030041)3.54117001
53protein localization to kinetochore (GO:0034501)3.52284200
54regulation of cardioblast proliferation (GO:0003264)3.50585860
55regulation of secondary heart field cardioblast proliferation (GO:0003266)3.50585860
56negative regulation of hormone biosynthetic process (GO:0032353)3.47762630
57regulation of fatty acid oxidation (GO:0046320)3.47626724
58positive regulation of fatty acid oxidation (GO:0046321)3.41346372
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40893218
60positive regulation of histone deacetylation (GO:0031065)3.40392053
61glutamate secretion (GO:0014047)3.39882344
62positive regulation of triglyceride biosynthetic process (GO:0010867)3.39668910
63energy homeostasis (GO:0097009)3.38456628
64negative regulation of appetite (GO:0032099)3.35910432
65negative regulation of response to food (GO:0032096)3.35910432
66negative regulation of glycogen biosynthetic process (GO:0045719)3.34319208
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.33972098
68negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.33578609
69negative regulation of protein tyrosine kinase activity (GO:0061099)3.33553336
70phosphatidylethanolamine metabolic process (GO:0046337)3.30311716
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26925924
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.25844728
73adaptation of signaling pathway (GO:0023058)3.25695417
74mitochondrial respiratory chain complex assembly (GO:0033108)3.24449105
75purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.23808126
763-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.23808126
77L-phenylalanine metabolic process (GO:0006558)3.23314526
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23314526
79L-phenylalanine catabolic process (GO:0006559)3.23087037
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.23087037
81vitamin biosynthetic process (GO:0009110)3.21873443
82negative regulation of histone methylation (GO:0031061)3.20548257
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17838986
84synaptic vesicle exocytosis (GO:0016079)3.17827374
85sodium ion export (GO:0071436)3.15980079
86pseudouridine synthesis (GO:0001522)3.14867090
87pharyngeal system development (GO:0060037)3.14618535
88cellular response to osmotic stress (GO:0071470)3.12827146
89regulation of translational fidelity (GO:0006450)3.10608642
90negative regulation of cell size (GO:0045792)3.09745797
91nucleosome disassembly (GO:0006337)3.09356037
92protein-DNA complex disassembly (GO:0032986)3.09356037
93spliceosomal tri-snRNP complex assembly (GO:0000244)3.07442546
94protein targeting to peroxisome (GO:0006625)3.06618766
95establishment of protein localization to peroxisome (GO:0072663)3.06618766
96protein localization to peroxisome (GO:0072662)3.06618766
97folic acid-containing compound biosynthetic process (GO:0009396)3.05202614
98cytochrome complex assembly (GO:0017004)3.04517002
99response to misfolded protein (GO:0051788)3.03989029
100regulation of postsynaptic membrane potential (GO:0060078)3.03540308
101regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02511792
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02139512
103protein localization to chromosome, centromeric region (GO:0071459)3.00865349
104glyoxylate metabolic process (GO:0046487)2.99955123
105deoxyribonucleotide catabolic process (GO:0009264)2.98665244
106regulation of synapse structural plasticity (GO:0051823)2.98149406
107negative regulation of glycogen metabolic process (GO:0070874)2.96821351
108cell migration in hindbrain (GO:0021535)2.96251595
109regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.95995364
110mitotic nuclear envelope disassembly (GO:0007077)2.95378999
111aorta morphogenesis (GO:0035909)2.95296186
112IMP biosynthetic process (GO:0006188)2.95177734
113nuclear envelope disassembly (GO:0051081)2.95151246
114membrane disassembly (GO:0030397)2.95151246
115exploration behavior (GO:0035640)2.95014035
116cellular response to BMP stimulus (GO:0071773)2.94213239
117response to BMP (GO:0071772)2.94213239
118peroxisomal transport (GO:0043574)2.91435589
119DNA replication-dependent nucleosome organization (GO:0034723)2.89483309
120DNA replication-dependent nucleosome assembly (GO:0006335)2.89483309
121glucocorticoid receptor signaling pathway (GO:0042921)2.88218833
122mammary gland alveolus development (GO:0060749)2.86439974
123negative regulation of hormone metabolic process (GO:0032351)2.85938736
124mitotic G1 DNA damage checkpoint (GO:0031571)2.85469210
125regulation of cholesterol storage (GO:0010885)2.85116873
126dendritic spine morphogenesis (GO:0060997)2.83531922
127histone H2A acetylation (GO:0043968)2.82490568
128regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.82041784
129regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.82041784
130mitotic chromosome condensation (GO:0007076)2.81475125
131neuromuscular process controlling posture (GO:0050884)2.80701789
132negative regulation of protein autophosphorylation (GO:0031953)2.80683917
133cerebellar Purkinje cell differentiation (GO:0021702)2.80491314
134thyroid gland development (GO:0030878)2.80384746
135regulation of glutamate receptor signaling pathway (GO:1900449)2.79666709
136regulation of mammary gland epithelial cell proliferation (GO:0033599)2.79579587
137positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.78653732
138tetrapyrrole biosynthetic process (GO:0033014)2.77561649
139behavioral response to cocaine (GO:0048148)2.77556490
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.76985750
141positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76150408
142prepulse inhibition (GO:0060134)2.75753076
143sister chromatid segregation (GO:0000819)2.75197791
144regulation of synaptic vesicle exocytosis (GO:2000300)2.74941724
145establishment of nucleus localization (GO:0040023)2.72473973
146mitotic sister chromatid segregation (GO:0000070)2.71226076
147positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.70446884
148negative regulation of RNA splicing (GO:0033119)2.69917572
149negative regulation of organelle assembly (GO:1902116)2.69605339
150cell communication by electrical coupling (GO:0010644)2.65794872
151activation of protein kinase A activity (GO:0034199)2.63720187
152neurotransmitter secretion (GO:0007269)2.62450857
153positive regulation of RNA splicing (GO:0033120)2.57602916
154protein localization to synapse (GO:0035418)2.56780275
155regulation of RNA export from nucleus (GO:0046831)2.56729721
156G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.55398351
157regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55071424
158histone H4-K5 acetylation (GO:0043981)2.55014454
159histone H4-K8 acetylation (GO:0043982)2.55014454
160nuclear pore organization (GO:0006999)2.54115079
161vocalization behavior (GO:0071625)2.52633363
162nuclear pore complex assembly (GO:0051292)2.52616431
163regulation of neuronal synaptic plasticity (GO:0048168)2.52435484
164regulation of DNA damage checkpoint (GO:2000001)2.51840712
165heterochromatin organization (GO:0070828)2.51499717
166protein complex localization (GO:0031503)2.51220254
167regulation of synaptic vesicle transport (GO:1902803)2.48805224
168dosage compensation (GO:0007549)2.46888814
169histone H4 acetylation (GO:0043967)2.46672223
170neuromuscular process controlling balance (GO:0050885)2.46322202
171nucleobase biosynthetic process (GO:0046112)2.46088335
172IMP metabolic process (GO:0046040)2.45644052
173NLS-bearing protein import into nucleus (GO:0006607)2.44489837
174ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.44440318
175regulation of synapse maturation (GO:0090128)2.43960426
176regulation of chromosome segregation (GO:0051983)2.40026728
177cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.39737131
178protein localization to chromosome (GO:0034502)2.39304503
179intracellular estrogen receptor signaling pathway (GO:0030520)2.38694976
180histone H4-K16 acetylation (GO:0043984)2.37439790
181mitotic spindle assembly checkpoint (GO:0007094)2.36929367
182DNA duplex unwinding (GO:0032508)2.36615338
183negative regulation of chromosome segregation (GO:0051985)2.35831080
184histone H2A monoubiquitination (GO:0035518)2.35743320
185negative regulation of gene expression, epigenetic (GO:0045814)2.34942851
186nuclear envelope organization (GO:0006998)2.34828145
187establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.34704314
188mitochondrion transport along microtubule (GO:0047497)2.34704314
189DNA geometric change (GO:0032392)2.34616970
190gene silencing (GO:0016458)2.33670021
191cellular potassium ion homeostasis (GO:0030007)2.32939531
192negative regulation of mitotic sister chromatid segregation (GO:0033048)2.32214852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.63730412
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.22268904
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35964067
4* MYC_22102868_ChIP-Seq_BL_Human3.33975716
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.58177924
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51624011
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.40189341
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39577172
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32892061
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30405897
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.27297677
12CIITA_25753668_ChIP-Seq_RAJI_Human2.23734531
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19899951
14EZH2_22144423_ChIP-Seq_EOC_Human2.19494824
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16412534
16* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.16002638
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07554223
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.04987525
19XRN2_22483619_ChIP-Seq_HELA_Human2.02247002
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.00906505
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99991780
22ZNF263_19887448_ChIP-Seq_K562_Human1.96591882
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93230727
24* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93192818
25KDM2B_26808549_Chip-Seq_DND41_Human1.91013939
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84478919
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.82528350
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80356166
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.79198096
30RACK7_27058665_Chip-Seq_MCF-7_Human1.78439149
31TP53_22127205_ChIP-Seq_IMR90_Human1.77268456
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76898140
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76562174
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76340328
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.74375618
36VDR_21846776_ChIP-Seq_THP-1_Human1.72245005
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71631857
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69670778
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.68627269
40CTCF_27219007_Chip-Seq_Bcells_Human1.68185312
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68146874
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67218781
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67070968
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67070968
45BCL6_27268052_Chip-Seq_Bcells_Human1.66558874
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65975097
47* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.65616832
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65493161
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64867392
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64740554
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63834018
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62055393
53* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.60494683
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59539037
55TCF7_22412390_ChIP-Seq_EML_Mouse1.58264162
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54896500
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53671893
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53609107
59MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53211790
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52530863
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52035201
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51176373
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50470016
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50071857
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.49764839
66KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48493371
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48035663
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48031329
69TP53_23651856_ChIP-Seq_MEFs_Mouse1.46016765
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.45897067
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45269256
72* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44591094
73* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44102734
74LXR_22292898_ChIP-Seq_THP-1_Human1.44027484
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.44015190
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.43621870
77AR_21909140_ChIP-Seq_LNCAP_Human1.43477971
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43329803
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.39605120
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39237038
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.38909225
82SMC3_22415368_ChIP-Seq_MEFs_Mouse1.38815330
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.37753733
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37153837
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37100128
86TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35065260
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34285642
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33775607
89KDM2B_26808549_Chip-Seq_K562_Human1.33197884
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32528529
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.32180098
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31398051
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30911639
94DROSHA_22980978_ChIP-Seq_HELA_Human1.30302444
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29675293
96P68_20966046_ChIP-Seq_HELA_Human1.29149639
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.28591822
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28426802
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28376131
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.28127069
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28053524
102CTCF_20526341_ChIP-Seq_ESCs_Human1.27249400
103CTCF_21964334_Chip-Seq_Bcells_Human1.26688736
104KDM5A_27292631_Chip-Seq_BREAST_Human1.26672091
105* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26646278
106GABP_19822575_ChIP-Seq_HepG2_Human1.26504263
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25610950
108PHF8_20622854_ChIP-Seq_HELA_Human1.25174488
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23955366
110* TP63_22573176_ChIP-Seq_HFKS_Human1.23453894
111SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23435388
112CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23093460
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22388889
114RNF2_27304074_Chip-Seq_ESCs_Mouse1.21948230
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.21402922
116GATA1_19941827_ChIP-Seq_MEL_Mouse1.21327408
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21051557
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.20446825
119RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19371899
120IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18925575
121SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18553440
122SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17899521
123BCOR_27268052_Chip-Seq_Bcells_Human1.17653871
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17241289
125REST_21632747_ChIP-Seq_MESCs_Mouse1.16796686
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.15924965
127SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12830257
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12791861
129* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11947531
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11683695
131CREB1_26743006_Chip-Seq_LNCaP_Human1.10579982
132TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10354603
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10349663
134GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10118074
135RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09971487
136TET1_21490601_ChIP-Seq_MESCs_Mouse1.09506451
137E2F1_20622854_ChIP-Seq_HELA_Human1.09328918
138ELK3_25401928_ChIP-Seq_HUVEC_Human1.09323140
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08157125
140TTF2_22483619_ChIP-Seq_HELA_Human1.07634111
141* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07223931
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06180427
143FOXP1_21924763_ChIP-Seq_HESCs_Human1.05587894
144RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05241528
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04132284
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02565858
147STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02272739
148SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01828077
149SMC4_20622854_ChIP-Seq_HELA_Human1.00727387
150ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99208462
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.99060210
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98138624
153CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97327583
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.97131492
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96810807
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.96624948
157NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95432423
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95430352
159* ATF3_27146783_Chip-Seq_COLON_Human0.95372244
160MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95037503
161PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93182605
162TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92819873
163P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92164339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.07904139
2MP0004859_abnormal_synaptic_plasticity5.15728493
3MP0004185_abnormal_adipocyte_glucose3.92914658
4MP0004130_abnormal_muscle_cell3.16610674
5MP0003123_paternal_imprinting3.02045709
6MP0001853_heart_inflammation2.92081336
7MP0005670_abnormal_white_adipose2.91986552
8MP0002653_abnormal_ependyma_morphology2.89496767
9MP0003635_abnormal_synaptic_transmissio2.67632886
10MP0000537_abnormal_urethra_morphology2.49175880
11MP0003111_abnormal_nucleus_morphology2.48903718
12MP0008961_abnormal_basal_metabolism2.26857594
13MP0005666_abnormal_adipose_tissue2.24078831
14MP0008775_abnormal_heart_ventricle2.20519981
15MP0010094_abnormal_chromosome_stability2.19396107
16MP0008877_abnormal_DNA_methylation2.12691648
17MP0004233_abnormal_muscle_weight2.11375172
18MP0000569_abnormal_digit_pigmentation2.09368229
19MP0004742_abnormal_vestibular_system2.09329110
20MP0002063_abnormal_learning/memory/cond2.06360864
21MP0001730_embryonic_growth_arrest2.01817615
22MP0004270_analgesia2.00191375
23MP0004957_abnormal_blastocyst_morpholog1.98846812
24MP0003077_abnormal_cell_cycle1.96980200
25MP0004858_abnormal_nervous_system1.82488223
26MP0004811_abnormal_neuron_physiology1.78668895
27MP0005423_abnormal_somatic_nervous1.73494283
28MP0003121_genomic_imprinting1.72816138
29MP0001905_abnormal_dopamine_level1.72550271
30MP0010234_abnormal_vibrissa_follicle1.69313369
31MP0003693_abnormal_embryo_hatching1.63701669
32MP0003122_maternal_imprinting1.61963267
33MP0005058_abnormal_lysosome_morphology1.61142132
34MP0009745_abnormal_behavioral_response1.54279681
35MP0003011_delayed_dark_adaptation1.53276269
36MP0000343_altered_response_to1.52673319
37MP0005187_abnormal_penis_morphology1.51198184
38MP0005076_abnormal_cell_differentiation1.51049246
39MP0002064_seizures1.51038188
40MP0002084_abnormal_developmental_patter1.49800290
41MP0000350_abnormal_cell_proliferation1.49453147
42MP0002909_abnormal_adrenal_gland1.43382316
43MP0009384_cardiac_valve_regurgitation1.42151995
44MP0000955_abnormal_spinal_cord1.41999474
45MP0003329_amyloid_beta_deposits1.41784821
46MP0003861_abnormal_nervous_system1.41769341
47MP0001697_abnormal_embryo_size1.41003246
48MP0001486_abnormal_startle_reflex1.39698069
49MP0008007_abnormal_cellular_replicative1.39248621
50MP0002184_abnormal_innervation1.38427312
51MP0003119_abnormal_digestive_system1.36495201
52MP0003705_abnormal_hypodermis_morpholog1.35429070
53MP0005375_adipose_tissue_phenotype1.32831203
54MP0002085_abnormal_embryonic_tissue1.32516948
55MP0002572_abnormal_emotion/affect_behav1.31571085
56MP0009672_abnormal_birth_weight1.31463510
57MP0003880_abnormal_central_pattern1.30192282
58MP0001968_abnormal_touch/_nociception1.30178000
59MP0009046_muscle_twitch1.30040254
60MP0000681_abnormal_thyroid_gland1.28469685
61MP0003787_abnormal_imprinting1.28397475
62MP0002152_abnormal_brain_morphology1.28040274
63MP0002080_prenatal_lethality1.27773366
64MP0000778_abnormal_nervous_system1.25908387
65MP0001672_abnormal_embryogenesis/_devel1.23403737
66MP0005380_embryogenesis_phenotype1.23403737
67MP0003633_abnormal_nervous_system1.22514620
68MP0010307_abnormal_tumor_latency1.22284743
69MP0002089_abnormal_postnatal_growth/wei1.21019834
70MP0002734_abnormal_mechanical_nocicepti1.20755328
71MP0000678_abnormal_parathyroid_gland1.19802933
72MP0000751_myopathy1.18811583
73MP0003942_abnormal_urinary_system1.18115306
74MP0010352_gastrointestinal_tract_polyps1.17214056
75MP0001849_ear_inflammation1.16759358
76MP0004197_abnormal_fetal_growth/weight/1.16423329
77MP0003984_embryonic_growth_retardation1.16316090
78MP0002822_catalepsy1.15237898
79MP0002088_abnormal_embryonic_growth/wei1.13227797
80MP0000534_abnormal_ureter_morphology1.11328500
81MP0001270_distended_abdomen1.10738732
82MP0008569_lethality_at_weaning1.09609486
83MP0003646_muscle_fatigue1.09154396
84MP0000049_abnormal_middle_ear1.09123524
85MP0003283_abnormal_digestive_organ1.09055839
86MP0008058_abnormal_DNA_repair1.08790169
87MP0004145_abnormal_muscle_electrophysio1.06759077
88MP0003879_abnormal_hair_cell1.06221537
89MP0004808_abnormal_hematopoietic_stem1.06088139
90MP0001970_abnormal_pain_threshold1.05494544
91MP0002269_muscular_atrophy1.05271230
92MP0002249_abnormal_larynx_morphology1.03298761
93MP0003115_abnormal_respiratory_system1.02264677
94MP0001346_abnormal_lacrimal_gland1.02087951
95MP0002733_abnormal_thermal_nociception1.01430173
96MP0001963_abnormal_hearing_physiology1.01303252
97MP0002882_abnormal_neuron_morphology1.01054283
98MP0002396_abnormal_hematopoietic_system0.99356658
99MP0002234_abnormal_pharynx_morphology0.98986185
100MP0005499_abnormal_olfactory_system0.98077193
101MP0005394_taste/olfaction_phenotype0.98077193
102MP0002735_abnormal_chemical_nociception0.96596621
103MP0002086_abnormal_extraembryonic_tissu0.96555759
104MP0002932_abnormal_joint_morphology0.96502173
105MP0005386_behavior/neurological_phenoty0.94592344
106MP0004924_abnormal_behavior0.94592344
107MP0008057_abnormal_DNA_replication0.94379374
108MP0010030_abnormal_orbit_morphology0.93099937
109MP0005623_abnormal_meninges_morphology0.92582802
110MP0003698_abnormal_male_reproductive0.90994462
111MP0008770_decreased_survivor_rate0.90568598
112MP0002066_abnormal_motor_capabilities/c0.89064100
113MP0001929_abnormal_gametogenesis0.88927413
114MP0002557_abnormal_social/conspecific_i0.86978831
115MP0002272_abnormal_nervous_system0.86509678
116MP0003221_abnormal_cardiomyocyte_apopto0.85976495
117MP0004885_abnormal_endolymph0.85432941
118MP0003890_abnormal_embryonic-extraembry0.85431386
119MP0002736_abnormal_nociception_after0.85374200
120MP0000747_muscle_weakness0.82515086
121MP0008932_abnormal_embryonic_tissue0.81201699
122MP0000428_abnormal_craniofacial_morphol0.81065501
123MP0001502_abnormal_circadian_rhythm0.80928457
124MP0002067_abnormal_sensory_capabilities0.80887782
125MP0004084_abnormal_cardiac_muscle0.79457198
126MP0000733_abnormal_muscle_development0.79209460
127MP0002161_abnormal_fertility/fecundity0.79047300
128MP0001440_abnormal_grooming_behavior0.78356595
129MP0004133_heterotaxia0.77982250
130MP0001727_abnormal_embryo_implantation0.77367367
131MP0000358_abnormal_cell_content/0.77105705
132MP0003631_nervous_system_phenotype0.75975119
133MP0002277_abnormal_respiratory_mucosa0.73247857
134MP0000026_abnormal_inner_ear0.72360463
135MP0005503_abnormal_tendon_morphology0.66997122
136MP0002106_abnormal_muscle_physiology0.66746336
137MP0005409_darkened_coat_color0.65513605
138MP0005334_abnormal_fat_pad0.63648793
139MP0002928_abnormal_bile_duct0.63398672
140MP0009764_decreased_sensitivity_to0.62679354
141MP0008789_abnormal_olfactory_epithelium0.62666718
142MP0003172_abnormal_lysosome_physiology0.61271608
143MP0003638_abnormal_response/metabolism_0.60548007
144MP0000230_abnormal_systemic_arterial0.59836268
145MP0009115_abnormal_fat_cell0.59661223
146MP0009250_abnormal_appendicular_skeleto0.59189283
147MP0009765_abnormal_xenobiotic_induced0.57596089
148MP0002160_abnormal_reproductive_system0.57521902
149MP0005408_hypopigmentation0.57082142
150MP0000538_abnormal_urinary_bladder0.55895301
151MP0001348_abnormal_lacrimal_gland0.54135590
152MP0001666_abnormal_nutrient_absorption0.52283727
153MP0001485_abnormal_pinna_reflex0.51498456
154MP0002876_abnormal_thyroid_physiology0.51180053
155MP0000015_abnormal_ear_pigmentation0.50609752
156MP0005332_abnormal_amino_acid0.50531017
157MP0009053_abnormal_anal_canal0.49925399
158MP0001188_hyperpigmentation0.48405750
159MP0001756_abnormal_urination0.45806225
160MP0000604_amyloidosis0.44648703
161MP0005584_abnormal_enzyme/coenzyme_acti0.43231279

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)5.66427333
2Methylmalonic aciduria (HP:0012120)5.58085880
3Methylmalonic acidemia (HP:0002912)5.14955657
4Short femoral neck (HP:0100864)4.19781230
5Abnormality of the lower motor neuron (HP:0002366)3.99237171
6Diplopia (HP:0000651)3.90858114
7Abnormality of binocular vision (HP:0011514)3.90858114
8Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.84676949
9Hyperacusis (HP:0010780)3.81231969
10Hyperthyroidism (HP:0000836)3.70823613
11Exostoses (HP:0100777)3.67142397
12Amblyopia (HP:0000646)3.64172123
13Myokymia (HP:0002411)3.61598023
14Asymmetry of the thorax (HP:0001555)3.52127228
15Subacute progressive viral hepatitis (HP:0006572)3.45735226
16Torticollis (HP:0000473)3.44350461
17Ependymoma (HP:0002888)3.38130768
18Insomnia (HP:0100785)3.37500717
19Lower limb asymmetry (HP:0100559)3.36560977
20Anxiety (HP:0000739)3.32566837
21Ulnar deviation of the wrist (HP:0003049)3.32450241
22Neonatal onset (HP:0003623)3.28056042
23Asymmetric septal hypertrophy (HP:0001670)3.27076178
24Small epiphyses (HP:0010585)3.18193714
25Pointed chin (HP:0000307)3.17210845
26Visual hallucinations (HP:0002367)3.12318079
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.09430498
28Dicarboxylic aciduria (HP:0003215)3.09430498
29* Cutaneous melanoma (HP:0012056)3.05871756
30Buphthalmos (HP:0000557)3.05343778
31Abnormality of the astrocytes (HP:0100707)3.02018505
32Astrocytoma (HP:0009592)3.02018505
33Renal duplication (HP:0000075)2.92382250
34Shoulder girdle muscle weakness (HP:0003547)2.89839188
35Joint stiffness (HP:0001387)2.87751692
36Irregular vertebral endplates (HP:0003301)2.86715763
37Elfin facies (HP:0004428)2.86452176
38Dysostosis multiplex (HP:0000943)2.84603469
39Congenital glaucoma (HP:0001087)2.84253311
40Neoplasm of the heart (HP:0100544)2.82708684
41Conjunctival hamartoma (HP:0100780)2.81622249
42Amyotrophic lateral sclerosis (HP:0007354)2.80536106
43Aplasia/hypoplasia of the femur (HP:0005613)2.79286884
44Lip pit (HP:0100267)2.78367326
45Spinal cord compression (HP:0002176)2.77135403
46Craniofacial dystonia (HP:0012179)2.73678789
47Multiple enchondromatosis (HP:0005701)2.69795856
48Visceral angiomatosis (HP:0100761)2.69348858
49Abnormality of the vitamin B12 metabolism (HP:0004341)2.65008978
50Pelvic girdle muscle weakness (HP:0003749)2.61656177
51Abdominal distention (HP:0003270)2.61390475
52Overriding aorta (HP:0002623)2.60325153
53Focal dystonia (HP:0004373)2.57904631
54Papilledema (HP:0001085)2.53636340
55Ovoid vertebral bodies (HP:0003300)2.53332984
56Increased nuchal translucency (HP:0010880)2.52088789
57Renovascular hypertension (HP:0100817)2.48669132
58Genu recurvatum (HP:0002816)2.46886631
59Ankyloglossia (HP:0010296)2.45761636
60Urinary urgency (HP:0000012)2.42244992
61Radial bowing (HP:0002986)2.41813150
62Bone cyst (HP:0012062)2.40925210
63Mucopolysacchariduria (HP:0008155)2.40338948
64Urinary glycosaminoglycan excretion (HP:0003541)2.40338948
65Hemangiomatosis (HP:0007461)2.40004065
66Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.39760508
67Short 4th metacarpal (HP:0010044)2.39760508
68Abnormality of the vertebral endplates (HP:0005106)2.38932978
69Depression (HP:0000716)2.37858558
70Vascular calcification (HP:0004934)2.36035128
71Annular pancreas (HP:0001734)2.35103950
72Dysmetric saccades (HP:0000641)2.34534227
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34262574
74Abnormality of serine family amino acid metabolism (HP:0010894)2.33823162
75Abnormality of glycine metabolism (HP:0010895)2.33823162
76Neoplasm of the adrenal cortex (HP:0100641)2.33713582
77Angiofibromas (HP:0010615)2.32820787
78Adenoma sebaceum (HP:0009720)2.32820787
79Abnormality of vitamin B metabolism (HP:0004340)2.32644224
80Impaired vibration sensation in the lower limbs (HP:0002166)2.32638285
81Focal seizures (HP:0007359)2.27542126
82Sacral dimple (HP:0000960)2.27211417
83Neurodegeneration (HP:0002180)2.26759433
84Colon cancer (HP:0003003)2.26492450
85Abnormality of the musculature of the pelvis (HP:0001469)2.25541224
86Abnormality of the hip-girdle musculature (HP:0001445)2.25541224
87Ureteral duplication (HP:0000073)2.24960084
88Delayed epiphyseal ossification (HP:0002663)2.24920753
89Ankle clonus (HP:0011448)2.23886021
90Genetic anticipation (HP:0003743)2.22369617
91Coronal craniosynostosis (HP:0004440)2.22103577
92Viral hepatitis (HP:0006562)2.21955408
93Incomplete penetrance (HP:0003829)2.21893034
94Hand muscle atrophy (HP:0009130)2.20780003
95Abnormality of subcutaneous fat tissue (HP:0001001)2.18598465
96Intention tremor (HP:0002080)2.18417720
97Heterotopia (HP:0002282)2.15258119
98Porencephaly (HP:0002132)2.14858301
99Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.14805665
100Hematochezia (HP:0002573)2.14026068
101Hyperammonemia (HP:0001987)2.13987445
102Obstructive sleep apnea (HP:0002870)2.12515790
103Goiter (HP:0000853)2.10248840
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10233431
105Abnormality of polysaccharide metabolism (HP:0011012)2.10233431
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10233431
107Bowed forearm bones (HP:0003956)2.09376567
108Bowing of the arm (HP:0006488)2.09376567
109Impaired smooth pursuit (HP:0007772)2.08501916
110Cardiovascular calcification (HP:0011915)2.08086818
111Ketosis (HP:0001946)2.07225952
112Mesomelia (HP:0003027)2.07225418
113Megalocornea (HP:0000485)2.07127515
114Glioma (HP:0009733)2.05729801
115Abnormality of oral frenula (HP:0000190)2.05700152
116Resting tremor (HP:0002322)2.05512893
117Bowel diverticulosis (HP:0005222)2.05364212
118Medulloblastoma (HP:0002885)2.04788947
119Agitation (HP:0000713)2.04579679
120Urinary bladder sphincter dysfunction (HP:0002839)2.04555725
121Distal upper limb amyotrophy (HP:0007149)2.04468624
122Upper limb amyotrophy (HP:0009129)2.04468624
123Respiratory distress (HP:0002098)2.02796100
124Abnormality of the labia minora (HP:0012880)2.02605920
125Intellectual disability, profound (HP:0002187)2.02322226
126Poor eye contact (HP:0000817)2.01660663
127Carpal bone hypoplasia (HP:0001498)2.01623798
128Spastic paraparesis (HP:0002313)2.01053148
129Fibroma (HP:0010614)2.00396151
130Long toe (HP:0010511)2.00318770
131Fibrous tissue neoplasm (HP:0012316)1.97007810
132Deep palmar crease (HP:0006191)1.96805943
133Abnormality of the proximal phalanges of the hand (HP:0009834)1.95955758
134Atrophy/Degeneration involving motor neurons (HP:0007373)1.94896119
135Abnormality of ocular smooth pursuit (HP:0000617)1.94745393
136Abnormality of the aortic arch (HP:0012303)1.93869797
137Hamartoma of the eye (HP:0010568)1.93132723
138Vertebral arch anomaly (HP:0008438)1.93095445
139Abnormality of the middle phalanges of the toes (HP:0010183)1.92569808
140Dysdiadochokinesis (HP:0002075)1.91804527
141Broad distal phalanx of finger (HP:0009836)1.91237105
142Termporal pattern (HP:0011008)1.90897873
143Insidious onset (HP:0003587)1.90897873
144Postural instability (HP:0002172)1.90562844
145Hypoplasia of the uterus (HP:0000013)1.90050968
146Mild short stature (HP:0003502)1.89995663
147Hyperkalemia (HP:0002153)1.89516043
148Turricephaly (HP:0000262)1.89374471
149Achilles tendon contracture (HP:0001771)1.89366573
150Abnormality of the 4th metacarpal (HP:0010012)1.88911919
151Obsessive-compulsive behavior (HP:0000722)1.88795725
152Neoplasm of the peripheral nervous system (HP:0100007)1.85751295
153Progressive cerebellar ataxia (HP:0002073)1.84817157
154Impaired social interactions (HP:0000735)1.84064049
155Abnormal social behavior (HP:0012433)1.84064049
156Truncal ataxia (HP:0002078)1.82809448
157Apathy (HP:0000741)1.82149046
158Mutism (HP:0002300)1.81855074
159Selective tooth agenesis (HP:0001592)1.78944349
160Generalized hypotonia (HP:0001290)1.77938371
161Abnormality of the motor neurons (HP:0002450)1.77316056
162Abnormal neuron morphology (HP:0012757)1.77316056
163Trigonocephaly (HP:0000243)1.76208260
164Flat cornea (HP:0007720)1.75457717
165Enlarged penis (HP:0000040)1.75143183
166Lymphangioma (HP:0100764)1.73896059
167Papillary thyroid carcinoma (HP:0002895)1.73456823
168Focal motor seizures (HP:0011153)1.73290975
169Broad palm (HP:0001169)1.72813107
170Supranuclear gaze palsy (HP:0000605)1.72062184
171Athetosis (HP:0002305)1.71341201
172High pitched voice (HP:0001620)1.69552840
173Neoplasm of striated muscle (HP:0009728)1.69181784
174Basal cell carcinoma (HP:0002671)1.69084816
175Posterior subcapsular cataract (HP:0007787)1.68238292
176Abnormality of the diencephalon (HP:0010662)1.67251339
177Attention deficit hyperactivity disorder (HP:0007018)1.67114608
178Diminished motivation (HP:0000745)1.66534307
179Hemiplegia (HP:0002301)1.64858081
180Bradykinesia (HP:0002067)1.64526833
181Intestinal polyp (HP:0005266)1.63937451
182Megalencephaly (HP:0001355)1.61992166
183Bundle branch block (HP:0011710)1.61099065
184Patellar aplasia (HP:0006443)1.60210524
185Neoplasm of the oral cavity (HP:0100649)1.58961766
186Spastic gait (HP:0002064)1.58339507
187Limb-girdle muscle atrophy (HP:0003797)1.57994749
188Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57722631
189Action tremor (HP:0002345)1.56709588

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K137.26429183
2FRK5.06731058
3FGFR24.06794936
4MAP3K93.26711208
5EEF2K3.25465877
6PKN22.92131850
7TRIB32.86849528
8NEK12.64402377
9PRKD32.49886354
10PRPF4B2.44047886
11MARK12.38188320
12KSR22.36067305
13KSR12.31135965
14MAP3K102.26796758
15CDC72.24764781
16MAP3K142.22377188
17SCYL22.19804377
18PASK2.05271330
19MINK11.93333518
20PAK61.90926607
21EPHB21.83957298
22PRKD21.82094218
23TAOK11.74011289
24LATS21.72099126
25NTRK31.71961398
26CAMKK11.71841166
27MAP3K41.68107719
28DAPK21.62327418
29BUB11.59714090
30BRSK11.59207466
31FGFR31.57212858
32SMG11.57045449
33ERN11.54464198
34NEK21.54314109
35NTRK21.52467387
36BCKDK1.51807470
37DAPK11.43007480
38TYRO31.42496219
39SIK11.40383996
40CCNB11.37363304
41ALK1.37089073
42EPHA41.26079879
43ICK1.25394164
44WEE11.19946296
45TSSK61.16831525
46EIF2AK11.11343273
47PDK41.09353855
48PDK31.09353855
49SGK11.09320095
50SIK21.08689272
51MAP2K31.06039230
52RIPK11.04210530
53RAF11.01227197
54UHMK11.01064044
55RET0.97496691
56TESK20.96380732
57PAK40.95830898
58IKBKB0.95671529
59CDK120.95322338
60TESK10.94611876
61STK380.89602407
62CDK150.89102262
63CDK180.89088487
64MAP4K10.88049417
65WNK10.86278510
66TAOK20.85152284
67MAP3K80.85023683
68SGK4940.83566972
69SGK2230.83566972
70PNCK0.83456395
71NTRK10.82324575
72CDK140.82225166
73SGK30.81269886
74CDK11A0.80730949
75TTK0.77490675
76IRAK30.77364105
77CDK50.76765001
78MAPK40.76552732
79JAK10.76034414
80CHEK10.75816247
81PDGFRA0.75018380
82PRKCZ0.74050799
83PLK10.72920803
84MAPK120.69300654
85PDPK10.69282387
86MAP2K40.68159198
87MTOR0.67825716
88MAPK130.67768335
89MAP2K20.64729284
90PINK10.62878879
91ABL20.62071022
92RPS6KB20.59924636
93DYRK30.59839261
94PHKG20.59579988
95PHKG10.59579988
96CDK20.59549701
97CDK190.59546348
98LRRK20.57967790
99ATR0.57700972
100CDK40.57057202
101PLK30.56010486
102STK110.55918460
103GRK60.54924092
104AKT20.54175833
105CHUK0.53505994
106SGK20.52443604
107TGFBR10.50846318
108RIPK40.50618366
109RPS6KA20.50158448
110ERBB20.49204283
111MAP3K30.48428958
112CHEK20.48215164
113PRKCQ0.48150247
114AURKA0.47985022
115MAP3K10.46782350
116PRKCH0.45992192
117RPS6KC10.45815026
118RPS6KL10.45815026
119MAP3K70.43961911
120RPS6KA60.43240211
121CDK10.42760404
122GRK50.42241453
123CSNK1E0.41927920
124LMTK20.40886894
125MAPK110.40643611
126PRKCG0.40505629
127PTK60.40293418
128MARK20.40151446
129TLK10.39645254
130DMPK0.39504385
131TTN0.39128755
132DAPK30.38891606
133FLT30.38646263
134FGFR10.38450109
135RPS6KA10.37586049
136PAK20.37559759
137TAOK30.37084044
138MAP3K110.36627261
139MAPK90.35342410
140PTK20.35133235
141PTK2B0.35073313
142PRKAA20.34700420
143BRAF0.34580429
144PDK10.34429472
145ROCK10.34046133
146ILK0.33631770
147MAPK100.33584543
148TNK20.33511922
149MAPK80.32984934
150ARAF0.32131263
151NME20.31561655
152FES0.31441050
153BRD40.31192097
154NEK90.30468663
155ZAP700.29513420
156HIPK20.27312063
157DDR20.25809942
158FYN0.24966274
159BMX0.24558726

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.43694102
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.72092451
3Adipocytokine signaling pathway_Homo sapiens_hsa049202.43170357
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38089814
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.21476177
6Fatty acid biosynthesis_Homo sapiens_hsa000612.11641309
7Synaptic vesicle cycle_Homo sapiens_hsa047212.07334617
8Sulfur relay system_Homo sapiens_hsa041222.04982512
9Oocyte meiosis_Homo sapiens_hsa041142.00407400
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87152420
11Long-term potentiation_Homo sapiens_hsa047201.82788581
12DNA replication_Homo sapiens_hsa030301.81976456
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.75461282
14RNA transport_Homo sapiens_hsa030131.75393841
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.75149637
16Spliceosome_Homo sapiens_hsa030401.74579874
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74109029
18Olfactory transduction_Homo sapiens_hsa047401.65681224
19Cell cycle_Homo sapiens_hsa041101.64392246
20mTOR signaling pathway_Homo sapiens_hsa041501.51124730
21Glioma_Homo sapiens_hsa052141.50866922
22mRNA surveillance pathway_Homo sapiens_hsa030151.50700618
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.47393376
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46526548
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44932239
26Circadian entrainment_Homo sapiens_hsa047131.44622238
27Glycerolipid metabolism_Homo sapiens_hsa005611.44553182
28Dopaminergic synapse_Homo sapiens_hsa047281.40997816
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40422061
30Insulin resistance_Homo sapiens_hsa049311.39116995
31Nicotine addiction_Homo sapiens_hsa050331.37874913
32Non-small cell lung cancer_Homo sapiens_hsa052231.33850016
33Colorectal cancer_Homo sapiens_hsa052101.30237042
34Base excision repair_Homo sapiens_hsa034101.28929602
35Amphetamine addiction_Homo sapiens_hsa050311.28862758
36Oxytocin signaling pathway_Homo sapiens_hsa049211.28619224
37Neurotrophin signaling pathway_Homo sapiens_hsa047221.24701282
38Biosynthesis of amino acids_Homo sapiens_hsa012301.23832222
39Endometrial cancer_Homo sapiens_hsa052131.23813043
40Gap junction_Homo sapiens_hsa045401.22724436
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22145009
42Mismatch repair_Homo sapiens_hsa034301.21354445
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21144215
44Estrogen signaling pathway_Homo sapiens_hsa049151.20141302
45GABAergic synapse_Homo sapiens_hsa047271.18768816
46Morphine addiction_Homo sapiens_hsa050321.15057441
47VEGF signaling pathway_Homo sapiens_hsa043701.14912752
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14865749
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14557487
50Glutamatergic synapse_Homo sapiens_hsa047241.13465720
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13007280
52Chronic myeloid leukemia_Homo sapiens_hsa052201.11731413
53Cholinergic synapse_Homo sapiens_hsa047251.09692070
54Alcoholism_Homo sapiens_hsa050341.09314713
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08012656
56Insulin secretion_Homo sapiens_hsa049111.06800639
57Type II diabetes mellitus_Homo sapiens_hsa049301.04958521
58GnRH signaling pathway_Homo sapiens_hsa049121.04597651
59Renin-angiotensin system_Homo sapiens_hsa046141.01735569
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00630273
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99256350
62Gastric acid secretion_Homo sapiens_hsa049710.97678496
63Glucagon signaling pathway_Homo sapiens_hsa049220.95577350
64ErbB signaling pathway_Homo sapiens_hsa040120.92785518
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92666469
66One carbon pool by folate_Homo sapiens_hsa006700.92659340
67Collecting duct acid secretion_Homo sapiens_hsa049660.92650326
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.92282340
69Insulin signaling pathway_Homo sapiens_hsa049100.91758342
70Thyroid cancer_Homo sapiens_hsa052160.91687058
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88187528
72Other glycan degradation_Homo sapiens_hsa005110.87462928
73Renal cell carcinoma_Homo sapiens_hsa052110.86453111
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.85466262
75Hippo signaling pathway_Homo sapiens_hsa043900.85328245
76Melanoma_Homo sapiens_hsa052180.82256118
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81472511
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80822337
79Melanogenesis_Homo sapiens_hsa049160.80646782
80Dorso-ventral axis formation_Homo sapiens_hsa043200.79595349
81B cell receptor signaling pathway_Homo sapiens_hsa046620.78977755
82Salivary secretion_Homo sapiens_hsa049700.78210701
83Acute myeloid leukemia_Homo sapiens_hsa052210.77697307
84Notch signaling pathway_Homo sapiens_hsa043300.77439920
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76619830
86Cocaine addiction_Homo sapiens_hsa050300.76593383
87Carbon metabolism_Homo sapiens_hsa012000.76168506
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75992731
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75944112
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74743990
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74424438
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74297997
93HIF-1 signaling pathway_Homo sapiens_hsa040660.73043668
94HTLV-I infection_Homo sapiens_hsa051660.72647249
95Hedgehog signaling pathway_Homo sapiens_hsa043400.72106602
96Renin secretion_Homo sapiens_hsa049240.71791218
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71723451
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.71402793
99Long-term depression_Homo sapiens_hsa047300.71238293
100Bladder cancer_Homo sapiens_hsa052190.70066681
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69581423
102PPAR signaling pathway_Homo sapiens_hsa033200.69457338
103AMPK signaling pathway_Homo sapiens_hsa041520.68833469
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68720444
105MicroRNAs in cancer_Homo sapiens_hsa052060.68158276
106Viral carcinogenesis_Homo sapiens_hsa052030.67584838
107FoxO signaling pathway_Homo sapiens_hsa040680.65987813
108Basal cell carcinoma_Homo sapiens_hsa052170.65689421
109Axon guidance_Homo sapiens_hsa043600.65613205
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65427042
111Wnt signaling pathway_Homo sapiens_hsa043100.65250213
112MAPK signaling pathway_Homo sapiens_hsa040100.64347664
113Rap1 signaling pathway_Homo sapiens_hsa040150.64334543
114Nucleotide excision repair_Homo sapiens_hsa034200.63898484
115Malaria_Homo sapiens_hsa051440.63363985
116Serotonergic synapse_Homo sapiens_hsa047260.63044517
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63024727
118Ras signaling pathway_Homo sapiens_hsa040140.61782159
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60825540
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60749723
121Calcium signaling pathway_Homo sapiens_hsa040200.59839453
122cAMP signaling pathway_Homo sapiens_hsa040240.58604850
123RNA degradation_Homo sapiens_hsa030180.56254881
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56222208
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56117891
126Pancreatic cancer_Homo sapiens_hsa052120.55898479
127Cardiac muscle contraction_Homo sapiens_hsa042600.55202083
128Epstein-Barr virus infection_Homo sapiens_hsa051690.52996058
129Endocytosis_Homo sapiens_hsa041440.52638296
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52404048
131Peroxisome_Homo sapiens_hsa041460.44000412
132Galactose metabolism_Homo sapiens_hsa000520.43766060
133Prion diseases_Homo sapiens_hsa050200.42212132
134T cell receptor signaling pathway_Homo sapiens_hsa046600.41011482
135Shigellosis_Homo sapiens_hsa051310.39942075
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38718889
137Tryptophan metabolism_Homo sapiens_hsa003800.36457698
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36241910
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.32205107
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30615079
141Prostate cancer_Homo sapiens_hsa052150.30518186

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