ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	5.13665873
2	kinetochore organization (GO:0051383)	4.89973201
3	protein localization to kinetochore (GO:0034501)	4.73743017
4	DNA unwinding involved in DNA replication (GO:0006268)	4.70966721
5	meiotic chromosome segregation (GO:0045132)	4.51436282
6	DNA replication initiation (GO:0006270)	4.48978524
7	replication fork processing (GO:0031297)	4.34259208
8	protein localization to chromosome, centromeric region (GO:0071459)	4.33172599
9	mitotic sister chromatid segregation (GO:0000070)	4.23802445
10	kinetochore assembly (GO:0051382)	4.22522946
11	chromatin remodeling at centromere (GO:0031055)	4.21258682
12	microtubule depolymerization (GO:0007019)	4.18165261
13	DNA strand elongation involved in DNA replication (GO:0006271)	4.17721933
14	CENP-A containing nucleosome assembly (GO:0034080)	4.14914894
15	nuclear pore complex assembly (GO:0051292)	4.13554999
16	DNA replication-dependent nucleosome organization (GO:0034723)	4.12157898
17	DNA replication-dependent nucleosome assembly (GO:0006335)	4.12157898
18	nuclear pore organization (GO:0006999)	4.06996269
19	mitotic metaphase plate congression (GO:0007080)	4.02553936
20	sister chromatid segregation (GO:0000819)	3.99692661
21	telomere maintenance via semi-conservative replication (GO:0032201)	3.99506460
22	DNA ligation (GO:0006266)	3.98838887
23	DNA strand elongation (GO:0022616)	3.97817594
24	attachment of spindle microtubules to kinetochore (GO:0008608)	3.96026653
25	DNA replication checkpoint (GO:0000076)	3.94865881
26	proteasome assembly (GO:0043248)	3.94342999
27	DNA catabolic process, exonucleolytic (GO:0000738)	3.88914924
28	mitotic chromosome condensation (GO:0007076)	3.88098117
29	metaphase plate congression (GO:0051310)	3.85384119
30	mitotic recombination (GO:0006312)	3.83267063
31	DNA replication-independent nucleosome organization (GO:0034724)	3.80248048
32	DNA replication-independent nucleosome assembly (GO:0006336)	3.80248048
33	telomere maintenance via recombination (GO:0000722)	3.74801538
34	mitotic G2/M transition checkpoint (GO:0044818)	3.73233202
35	non-recombinational repair (GO:0000726)	3.71770210
36	double-strand break repair via nonhomologous end joining (GO:0006303)	3.71770210
37	mitotic sister chromatid cohesion (GO:0007064)	3.65158243
38	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.61777431
39	regulation of mitotic spindle checkpoint (GO:1903504)	3.61777431
40	positive regulation of chromosome segregation (GO:0051984)	3.59372991
41	synapsis (GO:0007129)	3.58936975
42	histone exchange (GO:0043486)	3.56252131
43	centriole replication (GO:0007099)	3.56190894
44	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.55529345
45	negative regulation of sister chromatid segregation (GO:0033046)	3.55529345
46	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.55529345
47	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.55529345
48	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.55529345
49	regulation of histone H3-K9 methylation (GO:0051570)	3.55311657
50	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.53221676
51	establishment of integrated proviral latency (GO:0075713)	3.51397366
52	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.48078902
53	recombinational repair (GO:0000725)	3.47964129
54	double-strand break repair via homologous recombination (GO:0000724)	3.46343886
55	ribosomal small subunit biogenesis (GO:0042274)	3.45726529
56	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.45211549
57	negative regulation of DNA recombination (GO:0045910)	3.44456939
58	postreplication repair (GO:0006301)	3.40647395
59	regulation of DNA endoreduplication (GO:0032875)	3.37260537
60	maturation of SSU-rRNA (GO:0030490)	3.35218218
61	pore complex assembly (GO:0046931)	3.34459487
62	establishment of chromosome localization (GO:0051303)	3.33835937
63	purine nucleobase biosynthetic process (GO:0009113)	3.33702088
64	telomere maintenance via telomere lengthening (GO:0010833)	3.32221585
65	chromatin assembly or disassembly (GO:0006333)	3.32216515
66	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.30204123
67	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.30204123
68	isotype switching (GO:0045190)	3.30204123
69	response to X-ray (GO:0010165)	3.29988810
70	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.26913419
71	resolution of meiotic recombination intermediates (GO:0000712)	3.26361304
72	mitotic spindle assembly checkpoint (GO:0007094)	3.26136573
73	mismatch repair (GO:0006298)	3.25267006
74	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.23291965
75	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.23291965
76	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.23291965
77	regulation of helicase activity (GO:0051095)	3.16758508
78	regulation of meiosis I (GO:0060631)	3.16490953
79	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.15963453
80	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.15460308
81	DNA geometric change (GO:0032392)	3.14756491
82	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.14539882
83	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.14539882
84	DNA duplex unwinding (GO:0032508)	3.14074119
85	viral transcription (GO:0019083)	3.13527514
86	chromatin assembly (GO:0031497)	3.13381386
87	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.12907617
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.12431878
89	protein localization to chromosome (GO:0034502)	3.11087159
90	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	3.11052898
91	double-strand break repair (GO:0006302)	3.09645021
92	somatic recombination of immunoglobulin gene segments (GO:0016447)	3.09608424
93	translational termination (GO:0006415)	3.09378191
94	mitotic nuclear envelope disassembly (GO:0007077)	3.09323644
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.07312587
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.06082568
97	nucleobase biosynthetic process (GO:0046112)	3.04626400
98	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.03905847
99	DNA topological change (GO:0006265)	3.02899311
100	chromosome segregation (GO:0007059)	3.01255778
101	microtubule polymerization or depolymerization (GO:0031109)	2.99409705
102	spindle checkpoint (GO:0031577)	2.97568215
103	regulation of sister chromatid cohesion (GO:0007063)	2.94900817
104	regulation of centriole replication (GO:0046599)	2.94608348
105	regulation of centrosome cycle (GO:0046605)	2.94067687
106	DNA strand renaturation (GO:0000733)	2.93542018
107	regulation of chromosome segregation (GO:0051983)	2.91496182
108	regulation of telomere maintenance via telomerase (GO:0032210)	2.90253435
109	ATP-dependent chromatin remodeling (GO:0043044)	2.90231664
110	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.90227293
111	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.86469848
112	nuclear envelope disassembly (GO:0051081)	2.80924421
113	membrane disassembly (GO:0030397)	2.80924421
114	regulation of gene silencing by RNA (GO:0060966)	2.80603937
115	regulation of posttranscriptional gene silencing (GO:0060147)	2.80603937
116	regulation of gene silencing by miRNA (GO:0060964)	2.80603937
117	ribosomal large subunit biogenesis (GO:0042273)	2.80189919
118	DNA conformation change (GO:0071103)	2.79626393
119	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.78797857
120	pre-miRNA processing (GO:0031054)	2.78337722
121	telomere organization (GO:0032200)	2.78318410
122	telomere maintenance (GO:0000723)	2.78256073
123	regulation of double-strand break repair (GO:2000779)	2.77159960
124	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.75162924
125	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.74164860
126	negative regulation of chromosome segregation (GO:0051985)	2.73728649
127	regulation of mitotic sister chromatid segregation (GO:0033047)	2.73621626
128	regulation of sister chromatid segregation (GO:0033045)	2.73621626
129	regulation of mitotic sister chromatid separation (GO:0010965)	2.73621626
130	mitotic spindle checkpoint (GO:0071174)	2.72720481
131	spindle assembly checkpoint (GO:0071173)	2.72604930
132	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.72083297
133	V(D)J recombination (GO:0033151)	2.71648764
134	* protein K6-linked ubiquitination (GO:0085020)	2.71186357
135	negative regulation of histone methylation (GO:0031061)	2.69398705
136	ribonucleoprotein complex biogenesis (GO:0022613)	2.66551073

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	5.75336491
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	5.00157837
3	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.80616232
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.41795335
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.82773369
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.62362102
7	* MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.59717288
8	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.46622042
9	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.46622042
10	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.46622042
11	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.40892407
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.37065520
13	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.36460537
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.35971626
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.35673260
16	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.29980700
17	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.21768834
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.21749241
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.17675085
20	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.11209667
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.09669995
22	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	2.01392235
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.01185127
24	* AR_21909140_ChIP-Seq_LNCAP_Human	2.00291667
25	E2F7_22180533_ChIP-Seq_HELA_Human	11.8837771
26	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.94111649
27	* NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.82486011
28	VDR_22108803_ChIP-Seq_LS180_Human	1.81963405
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76353286
30	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.76232276
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.72741408
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71085673
33	ZNF274_21170338_ChIP-Seq_K562_Hela	1.67980412
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.66053718
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.65216280
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.63513460
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.62234347
38	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.61351729
39	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.60522760
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59742377
41	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59610471
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57846610
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.56962148
44	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.55863786
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.55219957
46	* POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.53573228
47	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.48088178
48	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46803599
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.46596852
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.44466937
51	* CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.37431499
52	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.36994009
53	P300_19829295_ChIP-Seq_ESCs_Human	1.33255886
54	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.32960923
55	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.32186942
56	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.30584645
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.30534279
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.26820418
59	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.26422751
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25012212
61	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24689208
62	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.23573600
63	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.23400840
64	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.23296345
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21312933
66	* IRF1_19129219_ChIP-ChIP_H3396_Human	1.20327692
67	MYC_18940864_ChIP-ChIP_HL60_Human	1.19645236
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.16413127
69	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15302184
70	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.14776469
71	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.13919048
72	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.12652042
73	FUS_26573619_Chip-Seq_HEK293_Human	1.08890580
74	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.04852593
75	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.04693277
76	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04499299
77	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.04448057
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04356884
79	EWS_26573619_Chip-Seq_HEK293_Human	1.02752439
80	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02292159
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01892234
82	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.00313033
83	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.00090630
84	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.99307073
85	* EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99121289
86	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.98361403
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.98049174
88	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.97040087
89	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96009760
90	GBX2_23144817_ChIP-Seq_PC3_Human	0.95465315
91	KDM5A_27292631_Chip-Seq_BREAST_Human	0.94638458
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93529226
93	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91253879
94	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.91120495
95	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.90926385
96	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.89590973
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.88278311
98	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.87594525
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.87405768
100	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.87281291
101	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85383350
102	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.84762037
103	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.84755094
104	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.84708027
105	* PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.83694103
106	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.83110515
107	* FLI1_27457419_Chip-Seq_LIVER_Mouse	0.82963786
108	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.81536062
109	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.81200387
110	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.81140620
111	GABP_19822575_ChIP-Seq_HepG2_Human	0.81001166
112	* NFE2_27457419_Chip-Seq_LIVER_Mouse	0.80365054
113	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.80291357
114	* SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.79979292
115	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.78642817
116	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.76579897
117	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.76481701
118	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.75950868
119	BCAT_22108803_ChIP-Seq_LS180_Human	0.75789360
120	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.75540278
121	* PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.75492141
122	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.75458035
123	* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.75087147
124	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.74852850
125	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.74832179
126	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.73256476
127	CBP_20019798_ChIP-Seq_JUKART_Human	0.73256476
128	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.71913099
129	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.71520855
130	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.71356772
131	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.71213432
132	NANOG_18692474_ChIP-Seq_MESCs_Mouse	0.70311074
133	* TCF3_18347094_ChIP-ChIP_MESCs_Mouse	0.68531960
134	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.68161815

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	4.95817316
2	* MP0010094_abnormal_chromosome_stability	4.53269575
3	MP0003111_abnormal_nucleus_morphology	3.88478068
4	MP0003693_abnormal_embryo_hatching	3.66537084
5	MP0003077_abnormal_cell_cycle	3.34644559
6	* MP0004957_abnormal_blastocyst_morpholog	3.17932049
7	MP0008058_abnormal_DNA_repair	3.05913369
8	MP0003136_yellow_coat_color	2.93187849
9	MP0008877_abnormal_DNA_methylation	2.79681218
10	MP0008932_abnormal_embryonic_tissue	2.57242386
11	MP0009697_abnormal_copulation	2.29143224
12	MP0006292_abnormal_olfactory_placode	2.25026309
13	MP0000372_irregular_coat_pigmentation	1.96112309
14	MP0003786_premature_aging	1.92116293
15	MP0000350_abnormal_cell_proliferation	1.89214884
16	MP0008007_abnormal_cellular_replicative	1.85962357
17	MP0003121_genomic_imprinting	1.77069107
18	MP0010307_abnormal_tumor_latency	1.69205997
19	MP0001730_embryonic_growth_arrest	1.67209921
20	MP0003937_abnormal_limbs/digits/tail_de	1.62265329
21	MP0002396_abnormal_hematopoietic_system	1.60406649
22	MP0008789_abnormal_olfactory_epithelium	1.55134686
23	MP0000566_synostosis	1.53559558
24	MP0003890_abnormal_embryonic-extraembry	1.53288797
25	MP0001293_anophthalmia	1.53030811
26	MP0003315_abnormal_perineum_morphology	1.51155626
27	MP0005409_darkened_coat_color	1.49319685
28	MP0002210_abnormal_sex_determination	1.48258146
29	MP0003123_paternal_imprinting	1.47595908
30	MP0002102_abnormal_ear_morphology	1.46767509
31	* MP0002085_abnormal_embryonic_tissue	1.46618386
32	MP0005380_embryogenesis_phenotype	1.43830259
33	MP0001672_abnormal_embryogenesis/_devel	1.43830259
34	MP0003938_abnormal_ear_development	1.42336024
35	MP0000490_abnormal_crypts_of	1.41410018
36	MP0002009_preneoplasia	1.40259436
37	MP0003787_abnormal_imprinting	1.39983573
38	MP0003718_maternal_effect	1.39394719
39	MP0004197_abnormal_fetal_growth/weight/	1.35657867
40	* MP0002084_abnormal_developmental_patter	1.34756081
41	MP0001188_hyperpigmentation	1.33394592
42	MP0004381_abnormal_hair_follicle	1.32991211
43	* MP0001697_abnormal_embryo_size	1.31948072
44	MP0003941_abnormal_skin_development	1.30034905
45	MP0008995_early_reproductive_senescence	1.28227647
46	MP0001145_abnormal_male_reproductive	1.23621479
47	MP0001929_abnormal_gametogenesis	1.22739002
48	MP0001119_abnormal_female_reproductive	1.18975838
49	MP0000383_abnormal_hair_follicle	1.18767283
50	MP0005394_taste/olfaction_phenotype	1.18302863
51	MP0005499_abnormal_olfactory_system	1.18302863
52	MP0002160_abnormal_reproductive_system	1.17980195
53	MP0006035_abnormal_mitochondrial_morpho	1.15643385
54	MP0003984_embryonic_growth_retardation	1.15275437
55	MP0003567_abnormal_fetal_cardiomyocyte	1.14555979
56	MP0001286_abnormal_eye_development	1.14005580
57	MP0003806_abnormal_nucleotide_metabolis	1.13693813
58	MP0000647_abnormal_sebaceous_gland	1.13097525
59	MP0000427_abnormal_hair_cycle	1.11995537
60	MP0000313_abnormal_cell_death	1.11957922
61	MP0002088_abnormal_embryonic_growth/wei	1.11883056
62	MP0002086_abnormal_extraembryonic_tissu	1.09125494
63	* MP0002080_prenatal_lethality	1.08156770
64	MP0005253_abnormal_eye_physiology	1.06932850
65	MP0005174_abnormal_tail_pigmentation	1.06864869
66	MP0005075_abnormal_melanosome_morpholog	1.06446075
67	MP0010352_gastrointestinal_tract_polyps	1.05062240
68	MP0002090_abnormal_vision	1.03757948
69	MP0000653_abnormal_sex_gland	1.03179156
70	MP0005171_absent_coat_pigmentation	1.02431320
71	MP0005395_other_phenotype	1.01836698
72	MP0005248_abnormal_Harderian_gland	1.01827161
73	MP0009379_abnormal_foot_pigmentation	1.01647887
74	MP0004133_heterotaxia	0.99786155
75	MP0000703_abnormal_thymus_morphology	0.99168705
76	MP0002234_abnormal_pharynx_morphology	0.98955850
77	MP0000432_abnormal_head_morphology	0.98288883
78	MP0002697_abnormal_eye_size	0.96149661
79	MP0002249_abnormal_larynx_morphology	0.95422809
80	MP0002092_abnormal_eye_morphology	0.95417446
81	MP0009672_abnormal_birth_weight	0.94791433
82	MP0001346_abnormal_lacrimal_gland	0.94669363
83	MP0006036_abnormal_mitochondrial_physio	0.94430760
84	* MP0002019_abnormal_tumor_incidence	0.93914059
85	* MP0003861_abnormal_nervous_system	0.92092886
86	MP0006072_abnormal_retinal_apoptosis	0.89962097
87	MP0003698_abnormal_male_reproductive	0.89772326
88	MP0003755_abnormal_palate_morphology	0.88752370
89	MP0003119_abnormal_digestive_system	0.88435190
90	MP0005389_reproductive_system_phenotype	0.87915459
91	MP0000537_abnormal_urethra_morphology	0.86982360
92	MP0001485_abnormal_pinna_reflex	0.86786657
93	MP0002938_white_spotting	0.86203551
94	MP0006054_spinal_hemorrhage	0.85612215
95	MP0002111_abnormal_tail_morphology	0.85409219
96	MP0002163_abnormal_gland_morphology	0.85060365
97	MP0001177_atelectasis	0.84573452
98	MP0000358_abnormal_cell_content/	0.84352768
99	MP0002095_abnormal_skin_pigmentation	0.83925542
100	MP0010678_abnormal_skin_adnexa	0.83389936
101	MP0005408_hypopigmentation	0.83092114
102	MP0002751_abnormal_autonomic_nervous	0.82887591
103	MP0000015_abnormal_ear_pigmentation	0.82493944
104	MP0000049_abnormal_middle_ear	0.81890488
105	MP0001727_abnormal_embryo_implantation	0.81367604
106	MP0002282_abnormal_trachea_morphology	0.80550952
107	MP0003950_abnormal_plasma_membrane	0.80195758
108	MP0005551_abnormal_eye_electrophysiolog	0.79848559
109	MP0002277_abnormal_respiratory_mucosa	0.79136972
110	MP0004808_abnormal_hematopoietic_stem	0.78651976
111	MP0001324_abnormal_eye_pigmentation	0.75400380
112	MP0003699_abnormal_female_reproductive	0.74754003
113	MP0000462_abnormal_digestive_system	0.74558125
114	MP0004215_abnormal_myocardial_fiber	0.74322044
115	MP0002736_abnormal_nociception_after	0.74161744
116	MP0009703_decreased_birth_body	0.73757885
117	MP0002114_abnormal_axial_skeleton	0.73737570
118	MP0003935_abnormal_craniofacial_develop	0.71720516
119	MP0010030_abnormal_orbit_morphology	0.71151435
120	MP0003763_abnormal_thymus_physiology	0.70064482
121	MP0001984_abnormal_olfaction	0.69824188
122	MP0005391_vision/eye_phenotype	0.69673449
123	MP0002161_abnormal_fertility/fecundity	0.69030655
124	MP0003186_abnormal_redox_activity	0.68866886
125	MP0001764_abnormal_homeostasis	0.68773958
126	MP0000428_abnormal_craniofacial_morphol	0.68722568
127	MP0001529_abnormal_vocalization	0.68709967
128	MP0002398_abnormal_bone_marrow	0.68159272
129	MP0005076_abnormal_cell_differentiation	0.66936662
130	MP0002722_abnormal_immune_system	0.66425076
131	MP0003936_abnormal_reproductive_system	0.66057777
132	MP0000762_abnormal_tongue_morphology	0.65954862
133	MP0002233_abnormal_nose_morphology	0.64900696
134	MP0005501_abnormal_skin_physiology	0.63829113
135	MP0000631_abnormal_neuroendocrine_gland	0.63731807
136	MP0002116_abnormal_craniofacial_bone	0.62531278

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.98988140
2	Chromsome breakage (HP:0040012)	5.95628490
3	Reticulocytopenia (HP:0001896)	4.02997825
4	Duplicated collecting system (HP:0000081)	3.92808523
5	Abnormality of chromosome stability (HP:0003220)	3.72431771
6	Abnormality of the preputium (HP:0100587)	3.53506960
7	Meckel diverticulum (HP:0002245)	3.47997388
8	Birth length less than 3rd percentile (HP:0003561)	3.45751745
9	Absent radius (HP:0003974)	3.45352807
10	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.42254078
11	Abnormality of the ileum (HP:0001549)	3.39187525
12	Aplasia involving forearm bones (HP:0009822)	3.32879077
13	Absent forearm bone (HP:0003953)	3.32879077
14	Abnormality of the renal collecting system (HP:0004742)	3.31553779
15	Abnormality of the labia minora (HP:0012880)	3.23806549
16	Ectopic kidney (HP:0000086)	3.10941234
17	Breast hypoplasia (HP:0003187)	2.98783703
18	Supernumerary spleens (HP:0009799)	2.97315242
19	Nephroblastoma (Wilms tumor) (HP:0002667)	2.88567004
20	Volvulus (HP:0002580)	2.83454151
21	Impulsivity (HP:0100710)	2.81874891
22	Absent thumb (HP:0009777)	2.74499037
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.72623946
24	Duodenal stenosis (HP:0100867)	2.70511695
25	Small intestinal stenosis (HP:0012848)	2.70511695
26	Asplenia (HP:0001746)	2.67850885
27	Medulloblastoma (HP:0002885)	2.66873906
28	Embryonal renal neoplasm (HP:0011794)	2.65281630
29	Glioma (HP:0009733)	2.60994405
30	Ependymoma (HP:0002888)	2.59590678
31	Patellar aplasia (HP:0006443)	2.54631712
32	Abnormal number of erythroid precursors (HP:0012131)	2.52946312
33	Short thumb (HP:0009778)	2.52480165
34	Triphalangeal thumb (HP:0001199)	2.51489414
35	Abnormal number of incisors (HP:0011064)	2.48094350
36	Rib fusion (HP:0000902)	2.46839682
37	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.46238572
38	Duplication of thumb phalanx (HP:0009942)	2.45704163
39	Facial hemangioma (HP:0000329)	2.44647572
40	Aplasia/Hypoplasia of the patella (HP:0006498)	2.39948859
41	Abnormal lung lobation (HP:0002101)	2.38376172
42	Selective tooth agenesis (HP:0001592)	2.36904665
43	Abnormality of the duodenum (HP:0002246)	2.36874946
44	Abnormality of DNA repair (HP:0003254)	2.34879197
45	Rhabdomyosarcoma (HP:0002859)	2.34274438
46	Horseshoe kidney (HP:0000085)	2.32029996
47	Abnormality of the carotid arteries (HP:0005344)	2.31040479
48	Myelodysplasia (HP:0002863)	2.29608350
49	Clubbing of toes (HP:0100760)	2.28420674
50	Esophageal atresia (HP:0002032)	2.28213198
51	Pallor (HP:0000980)	2.23271191
52	Neoplasm of the oral cavity (HP:0100649)	2.20325098
53	Bone marrow hypocellularity (HP:0005528)	2.20166934
54	Sloping forehead (HP:0000340)	2.18140404
55	Colon cancer (HP:0003003)	2.14981259
56	Macrocytic anemia (HP:0001972)	2.13166833
57	Pancreatic cysts (HP:0001737)	2.12615542
58	Neoplasm of the colon (HP:0100273)	2.11439985
59	Agnosia (HP:0010524)	2.11220742
60	Small hand (HP:0200055)	2.11118557
61	Premature graying of hair (HP:0002216)	2.09564735
62	Acute encephalopathy (HP:0006846)	2.08824386
63	Proximal placement of thumb (HP:0009623)	2.05644238
64	Acute necrotizing encephalopathy (HP:0006965)	2.03904195
65	Hyperglycinemia (HP:0002154)	2.01782424
66	Supernumerary bones of the axial skeleton (HP:0009144)	2.00985633
67	Pancreatic fibrosis (HP:0100732)	1.99317147
68	Tracheoesophageal fistula (HP:0002575)	1.99142861
69	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.98335716
70	Squamous cell carcinoma (HP:0002860)	1.96927482
71	Supernumerary ribs (HP:0005815)	1.95705377
72	Upper limb muscle weakness (HP:0003484)	1.93965920
73	Breast carcinoma (HP:0003002)	1.93816642
74	Parakeratosis (HP:0001036)	1.92734446
75	Absent septum pellucidum (HP:0001331)	1.92102401
76	Rectovaginal fistula (HP:0000143)	1.90846198
77	Rectal fistula (HP:0100590)	1.90846198
78	Astrocytoma (HP:0009592)	1.89568385
79	Abnormality of the astrocytes (HP:0100707)	1.89568385
80	Median cleft lip (HP:0000161)	1.88462632
81	Pancreatic islet-cell hyperplasia (HP:0004510)	1.87900331
82	Bifid tongue (HP:0010297)	1.87554216
83	Abnormality of the septum pellucidum (HP:0007375)	1.87550727
84	Deviation of the thumb (HP:0009603)	1.87248967
85	Preaxial hand polydactyly (HP:0001177)	1.87158700
86	Sensory axonal neuropathy (HP:0003390)	1.86835633
87	Carpal bone hypoplasia (HP:0001498)	1.85843836
88	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.85403120
89	Abdominal situs inversus (HP:0003363)	1.85332626
90	Abnormality of abdominal situs (HP:0011620)	1.85332626
91	Neoplasm of striated muscle (HP:0009728)	1.85295787
92	Abnormality of midbrain morphology (HP:0002418)	1.84469230
93	Molar tooth sign on MRI (HP:0002419)	1.84469230
94	Septo-optic dysplasia (HP:0100842)	1.83250877
95	Neoplasm of the adrenal cortex (HP:0100641)	1.82740392
96	True hermaphroditism (HP:0010459)	1.81519846
97	Astigmatism (HP:0000483)	1.80981826
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.80787637
99	Neoplasm of the adrenal gland (HP:0100631)	1.80706043
100	Embryonal neoplasm (HP:0002898)	1.80286188
101	Prostate neoplasm (HP:0100787)	1.80231874
102	Increased nuchal translucency (HP:0010880)	1.79776571
103	Increased CSF lactate (HP:0002490)	1.79768844
104	Atresia of the external auditory canal (HP:0000413)	1.79767120
105	Intestinal atresia (HP:0011100)	1.79718250
106	Ovarian neoplasm (HP:0100615)	1.79074449
107	Arteriovenous malformation (HP:0100026)	1.78594453
108	Oligodactyly (hands) (HP:0001180)	1.78257314
109	Abnormality of chromosome segregation (HP:0002916)	1.77992008
110	Basal cell carcinoma (HP:0002671)	1.77865694
111	Dandy-Walker malformation (HP:0001305)	1.77027525
112	Hypoplastic pelvis (HP:0008839)	1.76374289
113	Gastrointestinal atresia (HP:0002589)	1.76257169
114	Choanal atresia (HP:0000453)	1.75635233
115	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.75598987
116	Microtia (HP:0008551)	1.75226941
117	Abnormality of serum amino acid levels (HP:0003112)	1.74835746
118	Hypoplastic female external genitalia (HP:0012815)	1.73966756
119	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.73639000
120	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.73639000
121	Cafe-au-lait spot (HP:0000957)	1.73327276
122	Progressive macrocephaly (HP:0004481)	1.73306078
123	Short tibia (HP:0005736)	1.73091227
124	Intestinal fistula (HP:0100819)	1.71441955
125	Chin dimple (HP:0010751)	1.71251709
126	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.70867335
127	Abnormality of methionine metabolism (HP:0010901)	1.70493705
128	Neoplasm of the pancreas (HP:0002894)	1.69932322
129	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.69079403
130	Aplasia/hypoplasia of the humerus (HP:0006507)	1.69025363
131	Oligodactyly (HP:0012165)	1.64159454
132	Prominent nose (HP:0000448)	1.63396473
133	Aqueductal stenosis (HP:0002410)	1.63360510
134	Abnormal mitochondria in muscle tissue (HP:0008316)	1.63226020
135	Oligohydramnios (HP:0001562)	1.62859550
136	Cortical dysplasia (HP:0002539)	1.62220940
137	Mitochondrial inheritance (HP:0001427)	1.61453400
138	Increased hepatocellular lipid droplets (HP:0006565)	1.61218129
139	Abnormality of glycine metabolism (HP:0010895)	1.60398689
140	Abnormality of serine family amino acid metabolism (HP:0010894)	1.60398689
141	Large earlobe (HP:0009748)	1.60229349
142	Cerebral hypomyelination (HP:0006808)	1.57983139

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.84781152
2	WEE1	3.55544985
3	SRPK1	3.30130233
4	CDK12	3.14216323
5	TLK1	3.02478128
6	MKNK2	2.68899473
7	NEK2	2.65181000
8	MKNK1	2.57565338
9	TRIM28	2.51462944
10	BUB1	2.47144182
11	TTK	2.42244530
12	BMPR1B	2.37023497
13	VRK2	2.26494599
14	VRK1	2.18440203
15	CHEK2	2.14673513
16	PNCK	2.13669206
17	TAF1	2.01733451
18	BRD4	2.00198292
19	CDK7	1.97502085
20	PLK1	1.96701299
21	WNK3	1.89167762
22	BRSK2	1.75061092
23	STK4	1.70898135
24	ATR	1.70069424
25	CCNB1	1.69765994
26	AURKB	1.68767147
27	CLK1	1.65368013
28	STK16	1.56956937
29	CHEK1	1.53145853
30	EIF2AK1	1.52623567
31	DYRK3	1.50476713
32	CDK4	1.45176009
33	ERBB3	1.45165848
34	PLK2	1.40551386
35	PLK3	1.39836424
36	ZAK	1.32357723
37	PLK4	1.26122286
38	RPS6KB2	1.26023271
39	STK10	1.23955114
40	ATM	1.22836966
41	AURKA	1.21130973
42	MST4	1.18910522
43	YES1	1.17197654
44	ACVR1B	1.15747356
45	FGR	1.14821679
46	MAP4K2	1.10265276
47	PBK	1.08726699
48	MELK	1.06573311
49	TGFBR1	1.06343948
50	EIF2AK2	1.06239985
51	FRK	1.05829136
52	RPS6KA5	1.04329816
53	TSSK6	1.03683046
54	STK24	1.01173235
55	STK39	1.01036348
56	NME2	0.98159735
57	MAP3K8	0.96616413
58	* CDK2	0.96125880
59	CDK3	0.94618701
60	STK38L	0.94164298
61	CASK	0.93944540
62	CDK6	0.92327430
63	LATS1	0.91786449
64	PASK	0.89701652
65	PIM1	0.89406564
66	* CDK1	0.88066798
67	EPHA2	0.87872639
68	CDK9	0.87602930
69	ICK	0.84456249
70	DYRK2	0.80358329
71	CSNK1D	0.78445867
72	BRSK1	0.75242809
73	BCR	0.74690161
74	BLK	0.74081953
75	MAPK13	0.72354847
76	UHMK1	0.71774500
77	CSNK2A2	0.71765547
78	PKN1	0.65415113
79	CSNK1G3	0.64002919
80	STK3	0.63605620
81	CSNK1G1	0.60869056
82	ALK	0.59905505
83	CDK8	0.59651742
84	EIF2AK3	0.59575015
85	CSNK2A1	0.59505359
86	PRKDC	0.56681502
87	CSNK1E	0.55381133
88	CSNK1A1L	0.54943770
89	PDK2	0.51974188
90	MAPK14	0.50475218
91	GRK6	0.50389620
92	CSNK1G2	0.48927319
93	INSRR	0.48464640
94	RPS6KA4	0.46841570
95	AKT3	0.46746573
96	PRKD3	0.46433614
97	NLK	0.45664035
98	TESK2	0.44882479
99	GRK1	0.43787213
100	ERBB4	0.42988409
101	PAK1	0.41098032
102	PRKCI	0.39720417
103	WNK4	0.39677294
104	OXSR1	0.39451919
105	MET	0.39416994
106	AKT2	0.38896494
107	GSK3B	0.38327857
108	TRPM7	0.36994282
109	NEK1	0.36453246
110	MARK3	0.35852744
111	MINK1	0.35735473
112	BCKDK	0.35296076
113	EEF2K	0.35213975
114	AKT1	0.32625211
115	MTOR	0.32127928
116	MAPKAPK5	0.30883285
117	FLT3	0.30838672
118	TEC	0.30380373
119	NUAK1	0.30041280
120	BRAF	0.30037526
121	NME1	0.29822352
122	FGFR1	0.29190028
123	EPHA4	0.27974486
124	MAPK1	0.27503091
125	CDK11A	0.25309971
126	SIK3	0.24889432
127	CSK	0.24690035
128	PAK2	0.23572518
129	NEK6	0.23521347
130	MAP4K1	0.23368567
131	MAPK10	0.23241440
132	CDK15	0.23003300
133	FER	0.22618957
134	TNIK	0.22560018
135	MAP3K4	0.21869838
136	LCK	0.21159888

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	4.46587372
2	Mismatch repair_Homo sapiens_hsa03430	4.27547539
3	Homologous recombination_Homo sapiens_hsa03440	3.51168444
4	Fanconi anemia pathway_Homo sapiens_hsa03460	3.35121142
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.19146477
6	Non-homologous end-joining_Homo sapiens_hsa03450	3.13185867
7	Spliceosome_Homo sapiens_hsa03040	3.04660401
8	Ribosome_Homo sapiens_hsa03010	3.03012436
9	Cell cycle_Homo sapiens_hsa04110	2.81893944
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.78405924
11	Base excision repair_Homo sapiens_hsa03410	2.60978605
12	RNA transport_Homo sapiens_hsa03013	2.60408219
13	RNA polymerase_Homo sapiens_hsa03020	2.57363783
14	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.31600222
15	One carbon pool by folate_Homo sapiens_hsa00670	2.26472897
16	Basal transcription factors_Homo sapiens_hsa03022	2.20282158
17	mRNA surveillance pathway_Homo sapiens_hsa03015	2.06676634
18	Propanoate metabolism_Homo sapiens_hsa00640	1.97373140
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.81147157
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81075916
21	RNA degradation_Homo sapiens_hsa03018	1.80911161
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.74225212
23	p53 signaling pathway_Homo sapiens_hsa04115	1.58598114
24	Proteasome_Homo sapiens_hsa03050	1.38096722
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.36352958
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32121492
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26451126
28	Alcoholism_Homo sapiens_hsa05034	1.26112816
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22135419
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.21155808
31	Viral carcinogenesis_Homo sapiens_hsa05203	1.16481062
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12875607
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.12780350
34	Pyruvate metabolism_Homo sapiens_hsa00620	1.11701279
35	MicroRNAs in cancer_Homo sapiens_hsa05206	1.10201846
36	Fatty acid elongation_Homo sapiens_hsa00062	1.08894524
37	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.06342518
38	Oocyte meiosis_Homo sapiens_hsa04114	0.98627953
39	Selenocompound metabolism_Homo sapiens_hsa00450	0.96933212
40	Purine metabolism_Homo sapiens_hsa00230	0.96609452
41	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.94996962
42	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.90234641
43	Basal cell carcinoma_Homo sapiens_hsa05217	0.90000421
44	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.89362845
45	Herpes simplex infection_Homo sapiens_hsa05168	0.89328292
46	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.83249793
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82847761
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.79934325
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.79911961
50	HTLV-I infection_Homo sapiens_hsa05166	0.74123125
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.71312107
52	Small cell lung cancer_Homo sapiens_hsa05222	0.70758073
53	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.69703709
54	Butanoate metabolism_Homo sapiens_hsa00650	0.68211362
55	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.67870851
56	Wnt signaling pathway_Homo sapiens_hsa04310	0.67747183
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.67168797
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.66430243
59	Carbon metabolism_Homo sapiens_hsa01200	0.64696914
60	Huntingtons disease_Homo sapiens_hsa05016	0.64600504
61	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.62264638
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.62210944
63	Caffeine metabolism_Homo sapiens_hsa00232	0.60263102
64	Prostate cancer_Homo sapiens_hsa05215	0.60191052
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.59502828
66	Folate biosynthesis_Homo sapiens_hsa00790	0.59420160
67	Notch signaling pathway_Homo sapiens_hsa04330	0.58869226
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58114603
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.57443289
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.56627607
71	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.55550482
72	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54410223
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.52525182
74	Pathways in cancer_Homo sapiens_hsa05200	0.50573304
75	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.50318919
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.49957471
77	Metabolic pathways_Homo sapiens_hsa01100	0.49156724
78	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47173363
79	Peroxisome_Homo sapiens_hsa04146	0.46135386
80	Alzheimers disease_Homo sapiens_hsa05010	0.45639977
81	Nitrogen metabolism_Homo sapiens_hsa00910	0.45027876
82	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44384559
83	Melanoma_Homo sapiens_hsa05218	0.44193756
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.44177603
85	Colorectal cancer_Homo sapiens_hsa05210	0.43970251
86	Asthma_Homo sapiens_hsa05310	0.43514843
87	Linoleic acid metabolism_Homo sapiens_hsa00591	0.42827543
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42026403
89	Fatty acid degradation_Homo sapiens_hsa00071	0.41522376
90	Phototransduction_Homo sapiens_hsa04744	0.40730827
91	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.40525329
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.40102612
93	Measles_Homo sapiens_hsa05162	0.36591904
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.36316957
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.36309655
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.35886635
97	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35864228
98	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.34454121
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.34257572
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32489121
101	Hepatitis B_Homo sapiens_hsa05161	0.31746893
102	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31528915
103	Lysine degradation_Homo sapiens_hsa00310	0.30974393
104	Tight junction_Homo sapiens_hsa04530	0.30418935
105	Sphingolipid metabolism_Homo sapiens_hsa00600	0.29996054
106	Parkinsons disease_Homo sapiens_hsa05012	0.29893326
107	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29686318
108	Allograft rejection_Homo sapiens_hsa05330	0.29673484
109	Adherens junction_Homo sapiens_hsa04520	0.29642917
110	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29313074
111	Protein export_Homo sapiens_hsa03060	0.29150283
112	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.29015340
113	Axon guidance_Homo sapiens_hsa04360	0.29002774
114	Oxidative phosphorylation_Homo sapiens_hsa00190	0.28540488
115	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.27658435
116	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26861889
117	Bladder cancer_Homo sapiens_hsa05219	0.26143710
118	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.24691022
119	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24541576
120	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24383676
121	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.24192642
122	Apoptosis_Homo sapiens_hsa04210	0.24053602
123	Thyroid cancer_Homo sapiens_hsa05216	0.23751010
124	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.23519479
125	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.23383702
126	Pancreatic cancer_Homo sapiens_hsa05212	0.22667355
127	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.22422336
128	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.22411192
129	Olfactory transduction_Homo sapiens_hsa04740	0.22078859
130	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.21425057
131	Viral myocarditis_Homo sapiens_hsa05416	0.20862920
132	Sulfur metabolism_Homo sapiens_hsa00920	0.20846833
133	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.20442170
134	Glutathione metabolism_Homo sapiens_hsa00480	0.20373641
135	Regulation of autophagy_Homo sapiens_hsa04140	0.19827513
136	Non-small cell lung cancer_Homo sapiens_hsa05223	0.19649238
137	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.19220926
138	Renal cell carcinoma_Homo sapiens_hsa05211	0.18804462
139	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.18468288
140	Retinol metabolism_Homo sapiens_hsa00830	0.17744408
141	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.15776788
142	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.15673833
143	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.15645313
144	Chemical carcinogenesis_Homo sapiens_hsa05204	0.14394104
145	Pentose phosphate pathway_Homo sapiens_hsa00030	0.13656966
146	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.13541795
147	Arginine and proline metabolism_Homo sapiens_hsa00330	0.12850622

BARD1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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