

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | response to pheromone (GO:0019236) | 5.70441037 |
| 2 | presynaptic membrane organization (GO:0097090) | 5.32754054 |
| 3 | pyrimidine nucleobase catabolic process (GO:0006208) | 5.17015183 |
| 4 | neurofilament cytoskeleton organization (GO:0060052) | 4.80743309 |
| 5 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 4.78095837 |
| 6 | behavioral response to nicotine (GO:0035095) | 4.64880872 |
| 7 | daunorubicin metabolic process (GO:0044597) | 4.64297355 |
| 8 | polyketide metabolic process (GO:0030638) | 4.64297355 |
| 9 | doxorubicin metabolic process (GO:0044598) | 4.64297355 |
| 10 | vocalization behavior (GO:0071625) | 4.50594862 |
| 11 | postsynaptic membrane organization (GO:0001941) | 4.48693693 |
| 12 | presynaptic membrane assembly (GO:0097105) | 4.46445446 |
| 13 | regulation of synapse maturation (GO:0090128) | 4.45539662 |
| 14 | substrate-independent telencephalic tangential migration (GO:0021826) | 4.39775493 |
| 15 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 4.39775493 |
| 16 | establishment of mitochondrion localization (GO:0051654) | 4.39550431 |
| 17 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.38792085 |
| 18 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 4.33235849 |
| 19 | mitochondrion transport along microtubule (GO:0047497) | 4.33235849 |
| 20 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.27943307 |
| 21 | adult walking behavior (GO:0007628) | 4.16116258 |
| 22 | transmission of nerve impulse (GO:0019226) | 4.11931442 |
| 23 | exploration behavior (GO:0035640) | 4.10318914 |
| 24 | midbrain development (GO:0030901) | 4.08811475 |
| 25 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.06703094 |
| 26 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 4.05852151 |
| 27 | synaptic vesicle maturation (GO:0016188) | 4.00771656 |
| 28 | cerebellar granule cell differentiation (GO:0021707) | 3.96661308 |
| 29 | neuron cell-cell adhesion (GO:0007158) | 3.93534822 |
| 30 | negative regulation of mesenchymal cell apoptotic process (GO:2001054) | 3.92816528 |
| 31 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.84633656 |
| 32 | protein localization to synapse (GO:0035418) | 3.81914176 |
| 33 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.77490303 |
| 34 | striatum development (GO:0021756) | 3.69462543 |
| 35 | dendritic spine morphogenesis (GO:0060997) | 3.69118737 |
| 36 | layer formation in cerebral cortex (GO:0021819) | 3.66123108 |
| 37 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.62546205 |
| 38 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.60361929 |
| 39 | forebrain neuron differentiation (GO:0021879) | 3.57931695 |
| 40 | regulation of synapse structural plasticity (GO:0051823) | 3.56843068 |
| 41 | cerebellum development (GO:0021549) | 3.55113016 |
| 42 | positive regulation of gastrulation (GO:2000543) | 3.50649429 |
| 43 | glutamate secretion (GO:0014047) | 3.50417120 |
| 44 | glutamate receptor signaling pathway (GO:0007215) | 3.43729609 |
| 45 | cell differentiation in hindbrain (GO:0021533) | 3.43662482 |
| 46 | central nervous system myelination (GO:0022010) | 3.43170087 |
| 47 | axon ensheathment in central nervous system (GO:0032291) | 3.43170087 |
| 48 | axon extension (GO:0048675) | 3.43014173 |
| 49 | short-term memory (GO:0007614) | 3.42750580 |
| 50 | positive regulation of synapse maturation (GO:0090129) | 3.39896350 |
| 51 | nucleobase catabolic process (GO:0046113) | 3.39090479 |
| 52 | paraxial mesoderm development (GO:0048339) | 3.37143481 |
| 53 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.34310025 |
| 54 | positive regulation of synapse assembly (GO:0051965) | 3.33870982 |
| 55 | regulation of mesenchymal cell apoptotic process (GO:2001053) | 3.30350393 |
| 56 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.27744510 |
| 57 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.26225526 |
| 58 | spinal cord association neuron differentiation (GO:0021527) | 3.24643846 |
| 59 | prostate gland growth (GO:0060736) | 3.21342833 |
| 60 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.21331927 |
| 61 | detection of molecule of bacterial origin (GO:0032490) | 3.20264217 |
| 62 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.19663426 |
| 63 | positive regulation of dendritic spine development (GO:0060999) | 3.19149707 |
| 64 | limb bud formation (GO:0060174) | 3.18641480 |
| 65 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.17014544 |
| 66 | chaperone-mediated protein transport (GO:0072321) | 3.16348417 |
| 67 | response to histamine (GO:0034776) | 3.15438498 |
| 68 | atrial cardiac muscle cell action potential (GO:0086014) | 3.14879588 |
| 69 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 3.10332535 |
| 70 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 3.10332535 |
| 71 | positive regulation of neurotransmitter transport (GO:0051590) | 3.10213939 |
| 72 | behavioral response to cocaine (GO:0048148) | 3.09963680 |
| 73 | regulation of microtubule-based movement (GO:0060632) | 3.09884396 |
| 74 | retinal ganglion cell axon guidance (GO:0031290) | 3.08872973 |
| 75 | response to auditory stimulus (GO:0010996) | 3.06801600 |
| 76 | synaptic transmission, glutamatergic (GO:0035249) | 3.06657077 |
| 77 | hindbrain development (GO:0030902) | 3.06074451 |
| 78 | synaptic transmission, dopaminergic (GO:0001963) | 3.05758580 |
| 79 | dentate gyrus development (GO:0021542) | 3.05337962 |
| 80 | cellular anion homeostasis (GO:0030002) | 3.05086819 |
| 81 | dendrite morphogenesis (GO:0048813) | 3.04466051 |
| 82 | axonal fasciculation (GO:0007413) | 3.03595813 |
| 83 | dendritic spine organization (GO:0097061) | 3.03374762 |
| 84 | regulation of timing of cell differentiation (GO:0048505) | 3.03330140 |
| 85 | neurotransmitter secretion (GO:0007269) | 3.02390984 |
| 86 | regulation of respiratory system process (GO:0044065) | 3.01519920 |
| 87 | auditory receptor cell stereocilium organization (GO:0060088) | 3.00687112 |
| 88 | nonmotile primary cilium assembly (GO:0035058) | 3.00099887 |
| 89 | cellular potassium ion homeostasis (GO:0030007) | 2.99281303 |
| 90 | cell proliferation involved in metanephros development (GO:0072203) | 2.98207367 |
| 91 | regulation of postsynaptic membrane potential (GO:0060078) | 2.98024093 |
| 92 | cell migration in hindbrain (GO:0021535) | 2.97857428 |
| 93 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.97284462 |
| 94 | membrane hyperpolarization (GO:0060081) | 2.97118821 |
| 95 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.96991461 |
| 96 | establishment of tissue polarity (GO:0007164) | 2.96589938 |
| 97 | establishment of planar polarity (GO:0001736) | 2.96589938 |
| 98 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.96191773 |
| 99 | neuron projection extension (GO:1990138) | 2.95827481 |
| 100 | neuronal action potential propagation (GO:0019227) | 2.95632855 |
| 101 | behavioral fear response (GO:0001662) | 2.93555739 |
| 102 | behavioral defense response (GO:0002209) | 2.93555739 |
| 103 | synaptic vesicle endocytosis (GO:0048488) | 2.91862577 |
| 104 | central nervous system neuron differentiation (GO:0021953) | 2.91188419 |
| 105 | neuron maturation (GO:0042551) | 2.88036565 |
| 106 | astrocyte differentiation (GO:0048708) | 2.87222817 |
| 107 | hippocampus development (GO:0021766) | 2.87088307 |
| 108 | locomotory exploration behavior (GO:0035641) | 2.85922341 |
| 109 | synapse organization (GO:0050808) | 2.84744449 |
| 110 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.82992367 |
| 111 | left/right axis specification (GO:0070986) | 2.82450352 |
| 112 | fear response (GO:0042596) | 2.82101091 |
| 113 | inner ear receptor stereocilium organization (GO:0060122) | 2.79805498 |
| 114 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.79324648 |
| 115 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.79212390 |
| 116 | developmental pigmentation (GO:0048066) | 2.79067994 |
| 117 | dopamine receptor signaling pathway (GO:0007212) | 2.78401672 |
| 118 | behavioral response to ethanol (GO:0048149) | 2.77988769 |
| 119 | synapse assembly (GO:0007416) | 2.77810544 |
| 120 | neuronal ion channel clustering (GO:0045161) | 2.76400323 |
| 121 | auditory behavior (GO:0031223) | 2.75992067 |
| 122 | olfactory bulb development (GO:0021772) | 2.75571589 |
| 123 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339) | 2.75127097 |
| 124 | spinal cord development (GO:0021510) | 2.74541556 |
| 125 | regulation of dopamine secretion (GO:0014059) | 2.73845814 |
| 126 | regulation of male gonad development (GO:2000018) | 2.73773187 |
| 127 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.73431463 |
| 128 | regulation of development, heterochronic (GO:0040034) | 2.72684744 |
| 129 | cell differentiation in spinal cord (GO:0021515) | 2.72480789 |
| 130 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.72225605 |
| 131 | positive regulation of cellular amide metabolic process (GO:0034250) | 2.72181061 |
| 132 | positive regulation of membrane potential (GO:0045838) | 2.71804786 |
| 133 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.71715956 |
| 134 | urogenital system development (GO:0001655) | 2.71510967 |
| 135 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.70888965 |
| 136 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.70464527 |
| 137 | positive regulation of mast cell activation involved in immune response (GO:0033008) | 2.70259361 |
| 138 | positive regulation of mast cell degranulation (GO:0043306) | 2.70259361 |
| 139 | dendrite development (GO:0016358) | 2.68972647 |
| 140 | mating behavior (GO:0007617) | 2.68450865 |
| 141 | aminoglycoside antibiotic metabolic process (GO:0030647) | 2.63761352 |
| 142 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.61651010 |
| 143 | male sex determination (GO:0030238) | 2.60035827 |
| 144 | neuron recognition (GO:0008038) | 2.59889605 |
| 145 | regulation of synapse assembly (GO:0051963) | 2.58572379 |
| 146 | synaptic vesicle exocytosis (GO:0016079) | 2.58115086 |
| 147 | retina layer formation (GO:0010842) | 2.57438113 |
| 148 | neuron remodeling (GO:0016322) | 2.56534002 |
| 149 | regulation of synaptic vesicle transport (GO:1902803) | 2.55483635 |
| 150 | neuron-neuron synaptic transmission (GO:0007270) | 2.55027087 |
| 151 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.54466156 |
| 152 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.53766089 |
| 153 | mechanosensory behavior (GO:0007638) | 2.53303124 |
| 154 | regulation of respiratory gaseous exchange (GO:0043576) | 2.53241192 |
| 155 | central nervous system neuron axonogenesis (GO:0021955) | 2.53121473 |
| 156 | negative regulation of myoblast differentiation (GO:0045662) | 2.51460892 |
| 157 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.51319359 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.63040625 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.76531784 |
| 3 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 3.23188686 |
| 4 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.01859838 |
| 5 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.99547888 |
| 6 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.95994607 |
| 7 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.95463572 |
| 8 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.92932276 |
| 9 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.74121447 |
| 10 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.70431839 |
| 11 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.70431839 |
| 12 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.70323728 |
| 13 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.66167524 |
| 14 | * BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.65397442 |
| 15 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.62029702 |
| 16 | * CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.54957842 |
| 17 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.54288122 |
| 18 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 2.47714342 |
| 19 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.43889803 |
| 20 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.34484657 |
| 21 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.32692370 |
| 22 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 2.26454925 |
| 23 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.25668390 |
| 24 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.21657189 |
| 25 | * RNF2_27304074_Chip-Seq_NSC_Mouse | 2.13812241 |
| 26 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.10685856 |
| 27 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.02550159 |
| 28 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.99790383 |
| 29 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.94288770 |
| 30 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.91609909 |
| 31 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.87151381 |
| 32 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.86967205 |
| 33 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.76908510 |
| 34 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.76213664 |
| 35 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.73519403 |
| 36 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.72950783 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.72893828 |
| 38 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.71460266 |
| 39 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.67782119 |
| 40 | * ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.67710956 |
| 41 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.66839733 |
| 42 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.60456606 |
| 43 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.60181863 |
| 44 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.58461667 |
| 45 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.58049710 |
| 46 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.53044979 |
| 47 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.52407559 |
| 48 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.52330456 |
| 49 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.49690539 |
| 50 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.46334230 |
| 51 | * TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.44939947 |
| 52 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.43752351 |
| 53 | * RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.41443970 |
| 54 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.38908626 |
| 55 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.38157611 |
| 56 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.37305201 |
| 57 | * TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.36178057 |
| 58 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.34321105 |
| 59 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.34184812 |
| 60 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.33381500 |
| 61 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.30944995 |
| 62 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.23251844 |
| 63 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.22964573 |
| 64 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.22370132 |
| 65 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.21692818 |
| 66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.20565293 |
| 67 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.19651671 |
| 68 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.19651671 |
| 69 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.19104612 |
| 70 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.18957184 |
| 71 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.17769116 |
| 72 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.17525352 |
| 73 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.16498216 |
| 74 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.16472063 |
| 75 | VDR_22108803_ChIP-Seq_LS180_Human | 1.16208049 |
| 76 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 1.16165045 |
| 77 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.15440550 |
| 78 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.14690801 |
| 79 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.14325760 |
| 80 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.13590109 |
| 81 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.13384211 |
| 82 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.12924309 |
| 83 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.12728482 |
| 84 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.12518924 |
| 85 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.12254152 |
| 86 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.11281248 |
| 87 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.11262275 |
| 88 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.10388119 |
| 89 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.08897749 |
| 90 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.08655417 |
| 91 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.07761057 |
| 92 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.07073654 |
| 93 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.06248427 |
| 94 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.04679123 |
| 95 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.04324753 |
| 96 | STAT3_23295773_ChIP-Seq_U87_Human | 1.03956712 |
| 97 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.03858913 |
| 98 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.03849661 |
| 99 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.03803006 |
| 100 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.03685807 |
| 101 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.02769110 |
| 102 | * AR_19668381_ChIP-Seq_PC3_Human | 1.01702215 |
| 103 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.01174695 |
| 104 | * MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.00358281 |
| 105 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.99881658 |
| 106 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 0.99846993 |
| 107 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.98335473 |
| 108 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.98258755 |
| 109 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.97864746 |
| 110 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.97124883 |
| 111 | * TCF4_23295773_ChIP-Seq_U87_Human | 0.97048948 |
| 112 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.95646308 |
| 113 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.94413849 |
| 114 | * EWS_26573619_Chip-Seq_HEK293_Human | 0.93685706 |
| 115 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.93461702 |
| 116 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.92201504 |
| 117 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.91634442 |
| 118 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.88263184 |
| 119 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.87043552 |
| 120 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.86776192 |
| 121 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.85123405 |
| 122 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.84174717 |
| 123 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.82808156 |
| 124 | * SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.81605818 |
| 125 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.80892899 |
| 126 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.79990681 |
| 127 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.76850218 |
| 128 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.76277730 |
| 129 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.75253615 |
| 130 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.75136812 |
| 131 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.74853275 |
| 132 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.73999972 |
| 133 | MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse | 0.73637804 |
| 134 | REST_19997604_ChIP-ChIP_NEURONS_Mouse | 0.73086777 |
| 135 | FUS_26573619_Chip-Seq_HEK293_Human | 0.71942981 |
| 136 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.71842102 |
| 137 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.71790849 |
| 138 | STAT3_18555785_ChIP-Seq_MESCs_Mouse | 0.71714171 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 3.98566240 |
| 2 | MP0005423_abnormal_somatic_nervous | 3.55188394 |
| 3 | MP0000566_synostosis | 3.47847025 |
| 4 | MP0002653_abnormal_ependyma_morphology | 3.29157398 |
| 5 | MP0006276_abnormal_autonomic_nervous | 3.26651256 |
| 6 | MP0003123_paternal_imprinting | 3.11973315 |
| 7 | MP0001188_hyperpigmentation | 2.87596104 |
| 8 | MP0005646_abnormal_pituitary_gland | 2.68030412 |
| 9 | MP0002822_catalepsy | 2.66441248 |
| 10 | MP0004859_abnormal_synaptic_plasticity | 2.50228724 |
| 11 | MP0002638_abnormal_pupillary_reflex | 2.49794385 |
| 12 | MP0006292_abnormal_olfactory_placode | 2.45080770 |
| 13 | MP0009046_muscle_twitch | 2.41664392 |
| 14 | MP0000778_abnormal_nervous_system | 2.34958769 |
| 15 | MP0002102_abnormal_ear_morphology | 2.13870260 |
| 16 | MP0005645_abnormal_hypothalamus_physiol | 2.13111140 |
| 17 | MP0008877_abnormal_DNA_methylation | 2.12788004 |
| 18 | MP0002938_white_spotting | 2.10064423 |
| 19 | MP0003635_abnormal_synaptic_transmissio | 2.09944883 |
| 20 | MP0002184_abnormal_innervation | 2.05546356 |
| 21 | MP0001486_abnormal_startle_reflex | 2.01706283 |
| 22 | MP0001984_abnormal_olfaction | 1.95065508 |
| 23 | MP0003121_genomic_imprinting | 1.95061815 |
| 24 | MP0002557_abnormal_social/conspecific_i | 1.94449525 |
| 25 | MP0002063_abnormal_learning/memory/cond | 1.88046991 |
| 26 | MP0001348_abnormal_lacrimal_gland | 1.85687316 |
| 27 | MP0005394_taste/olfaction_phenotype | 1.84404095 |
| 28 | MP0005499_abnormal_olfactory_system | 1.84404095 |
| 29 | MP0009745_abnormal_behavioral_response | 1.83670538 |
| 30 | MP0001502_abnormal_circadian_rhythm | 1.82508911 |
| 31 | MP0008789_abnormal_olfactory_epithelium | 1.82014680 |
| 32 | MP0004742_abnormal_vestibular_system | 1.81543178 |
| 33 | MP0001529_abnormal_vocalization | 1.76224406 |
| 34 | MP0001346_abnormal_lacrimal_gland | 1.76165724 |
| 35 | MP0009379_abnormal_foot_pigmentation | 1.75905581 |
| 36 | MP0010030_abnormal_orbit_morphology | 1.72717289 |
| 37 | MP0002572_abnormal_emotion/affect_behav | 1.72472920 |
| 38 | MP0003122_maternal_imprinting | 1.68074065 |
| 39 | MP0002067_abnormal_sensory_capabilities | 1.67641166 |
| 40 | MP0002064_seizures | 1.64817291 |
| 41 | MP0002163_abnormal_gland_morphology | 1.58943487 |
| 42 | MP0003283_abnormal_digestive_organ | 1.55142821 |
| 43 | MP0001968_abnormal_touch/_nociception | 1.54929998 |
| 44 | MP0002734_abnormal_mechanical_nocicepti | 1.51420530 |
| 45 | MP0000631_abnormal_neuroendocrine_gland | 1.50638087 |
| 46 | MP0002272_abnormal_nervous_system | 1.49470627 |
| 47 | MP0008569_lethality_at_weaning | 1.48351354 |
| 48 | MP0008995_early_reproductive_senescence | 1.45272143 |
| 49 | MP0001440_abnormal_grooming_behavior | 1.44591506 |
| 50 | MP0003879_abnormal_hair_cell | 1.41345289 |
| 51 | MP0004145_abnormal_muscle_electrophysio | 1.39912944 |
| 52 | MP0002736_abnormal_nociception_after | 1.38890270 |
| 53 | MP0003136_yellow_coat_color | 1.38867426 |
| 54 | MP0005409_darkened_coat_color | 1.38667653 |
| 55 | MP0002234_abnormal_pharynx_morphology | 1.37888819 |
| 56 | MP0002735_abnormal_chemical_nociception | 1.37297274 |
| 57 | MP0000026_abnormal_inner_ear | 1.33163800 |
| 58 | MP0005377_hearing/vestibular/ear_phenot | 1.31709381 |
| 59 | MP0003878_abnormal_ear_physiology | 1.31709381 |
| 60 | MP0002909_abnormal_adrenal_gland | 1.28917829 |
| 61 | MP0005171_absent_coat_pigmentation | 1.28187394 |
| 62 | MP0002876_abnormal_thyroid_physiology | 1.27866339 |
| 63 | MP0005187_abnormal_penis_morphology | 1.25411490 |
| 64 | MP0000955_abnormal_spinal_cord | 1.23473224 |
| 65 | MP0002751_abnormal_autonomic_nervous | 1.22718318 |
| 66 | MP0003890_abnormal_embryonic-extraembry | 1.22129487 |
| 67 | MP0000015_abnormal_ear_pigmentation | 1.21274023 |
| 68 | MP0009697_abnormal_copulation | 1.20596363 |
| 69 | * MP0002882_abnormal_neuron_morphology | 1.18930396 |
| 70 | MP0004924_abnormal_behavior | 1.14611380 |
| 71 | MP0005386_behavior/neurological_phenoty | 1.14611380 |
| 72 | MP0001501_abnormal_sleep_pattern | 1.09612735 |
| 73 | MP0001905_abnormal_dopamine_level | 1.09187680 |
| 74 | * MP0005551_abnormal_eye_electrophysiolog | 1.07805246 |
| 75 | MP0004811_abnormal_neuron_physiology | 1.07626102 |
| 76 | MP0004142_abnormal_muscle_tone | 1.06838744 |
| 77 | * MP0002752_abnormal_somatic_nervous | 1.06032264 |
| 78 | MP0002152_abnormal_brain_morphology | 1.04370155 |
| 79 | MP0004133_heterotaxia | 1.03815489 |
| 80 | MP0003787_abnormal_imprinting | 1.02224233 |
| 81 | MP0005379_endocrine/exocrine_gland_phen | 1.01207542 |
| 82 | MP0000538_abnormal_urinary_bladder | 1.00182015 |
| 83 | MP0003137_abnormal_impulse_conducting | 0.99657332 |
| 84 | MP0010386_abnormal_urinary_bladder | 0.97307797 |
| 85 | MP0006072_abnormal_retinal_apoptosis | 0.94356167 |
| 86 | MP0005174_abnormal_tail_pigmentation | 0.94317247 |
| 87 | MP0002229_neurodegeneration | 0.94239207 |
| 88 | MP0005253_abnormal_eye_physiology | 0.93100436 |
| 89 | MP0003938_abnormal_ear_development | 0.91778464 |
| 90 | MP0002928_abnormal_bile_duct | 0.91219896 |
| 91 | MP0001963_abnormal_hearing_physiology | 0.90341195 |
| 92 | MP0003119_abnormal_digestive_system | 0.89660506 |
| 93 | * MP0002066_abnormal_motor_capabilities/c | 0.89479806 |
| 94 | MP0002249_abnormal_larynx_morphology | 0.88457243 |
| 95 | MP0004782_abnormal_surfactant_physiolog | 0.87611600 |
| 96 | * MP0005195_abnormal_posterior_eye | 0.87402211 |
| 97 | MP0003861_abnormal_nervous_system | 0.87218022 |
| 98 | MP0001299_abnormal_eye_distance/ | 0.86547005 |
| 99 | MP0001970_abnormal_pain_threshold | 0.86311089 |
| 100 | MP0003385_abnormal_body_wall | 0.84860586 |
| 101 | MP0003329_amyloid_beta_deposits | 0.84579191 |
| 102 | MP0000049_abnormal_middle_ear | 0.83607254 |
| 103 | MP0001485_abnormal_pinna_reflex | 0.83337782 |
| 104 | MP0005389_reproductive_system_phenotype | 0.83053757 |
| 105 | MP0004270_analgesia | 0.82514533 |
| 106 | MP0002160_abnormal_reproductive_system | 0.82257323 |
| 107 | MP0000569_abnormal_digit_pigmentation | 0.82024196 |
| 108 | MP0001919_abnormal_reproductive_system | 0.80046185 |
| 109 | MP0000678_abnormal_parathyroid_gland | 0.79228916 |
| 110 | MP0004885_abnormal_endolymph | 0.78594631 |
| 111 | MP0003942_abnormal_urinary_system | 0.78471298 |
| 112 | MP0009053_abnormal_anal_canal | 0.77943429 |
| 113 | MP0004858_abnormal_nervous_system | 0.77679990 |
| 114 | MP0005248_abnormal_Harderian_gland | 0.77202285 |
| 115 | MP0003315_abnormal_perineum_morphology | 0.76263881 |
| 116 | MP0005391_vision/eye_phenotype | 0.75419299 |
| 117 | MP0003183_abnormal_peptide_metabolism | 0.75054176 |
| 118 | MP0002733_abnormal_thermal_nociception | 0.74808365 |
| 119 | MP0000681_abnormal_thyroid_gland | 0.74520468 |
| 120 | MP0002116_abnormal_craniofacial_bone | 0.69646508 |
| 121 | MP0002069_abnormal_eating/drinking_beha | 0.68239135 |
| 122 | MP0002233_abnormal_nose_morphology | 0.68154663 |
| 123 | MP0001986_abnormal_taste_sensitivity | 0.66267723 |
| 124 | MP0003633_abnormal_nervous_system | 0.66196069 |
| 125 | MP0001293_anophthalmia | 0.65639796 |
| 126 | MP0002210_abnormal_sex_determination | 0.64862800 |
| 127 | MP0003698_abnormal_male_reproductive | 0.64813243 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 7.52211852 |
| 2 | Febrile seizures (HP:0002373) | 4.73616215 |
| 3 | Focal motor seizures (HP:0011153) | 4.30789319 |
| 4 | Abnormality of the corticospinal tract (HP:0002492) | 3.82753485 |
| 5 | Progressive cerebellar ataxia (HP:0002073) | 3.82627076 |
| 6 | Limb dystonia (HP:0002451) | 3.50343766 |
| 7 | True hermaphroditism (HP:0010459) | 3.39795123 |
| 8 | Polyphagia (HP:0002591) | 3.26873941 |
| 9 | Septo-optic dysplasia (HP:0100842) | 3.16203536 |
| 10 | Elfin facies (HP:0004428) | 3.09747097 |
| 11 | Hypoplasia of the fovea (HP:0007750) | 3.09378528 |
| 12 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.09378528 |
| 13 | Narrow nasal bridge (HP:0000446) | 3.04703893 |
| 14 | Optic nerve hypoplasia (HP:0000609) | 3.04622980 |
| 15 | Drooling (HP:0002307) | 2.99502187 |
| 16 | Epileptic encephalopathy (HP:0200134) | 2.99038464 |
| 17 | Abnormal sex determination (HP:0012244) | 2.91956866 |
| 18 | Sex reversal (HP:0012245) | 2.91956866 |
| 19 | Hyperventilation (HP:0002883) | 2.89024980 |
| 20 | Abnormal pancreas size (HP:0012094) | 2.87892497 |
| 21 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.79044509 |
| 22 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.79044509 |
| 23 | Supranuclear gaze palsy (HP:0000605) | 2.76500380 |
| 24 | Atonic seizures (HP:0010819) | 2.76097651 |
| 25 | Excessive salivation (HP:0003781) | 2.73830860 |
| 26 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.73248145 |
| 27 | Protruding tongue (HP:0010808) | 2.72551969 |
| 28 | Maternal diabetes (HP:0009800) | 2.72485246 |
| 29 | Anomalous pulmonary venous return (HP:0010772) | 2.65410331 |
| 30 | Abnormal number of incisors (HP:0011064) | 2.63643962 |
| 31 | Abnormal eating behavior (HP:0100738) | 2.61483993 |
| 32 | Focal seizures (HP:0007359) | 2.59978628 |
| 33 | Genetic anticipation (HP:0003743) | 2.59592533 |
| 34 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.59010999 |
| 35 | Absent/shortened dynein arms (HP:0200106) | 2.59010999 |
| 36 | Severe visual impairment (HP:0001141) | 2.55898916 |
| 37 | Abnormality of the lower motor neuron (HP:0002366) | 2.54312742 |
| 38 | Rib fusion (HP:0000902) | 2.53020493 |
| 39 | Renovascular hypertension (HP:0100817) | 2.52852428 |
| 40 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.48765765 |
| 41 | Amblyopia (HP:0000646) | 2.47622271 |
| 42 | Medial flaring of the eyebrow (HP:0010747) | 2.45424700 |
| 43 | Nephrogenic diabetes insipidus (HP:0009806) | 2.45319356 |
| 44 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.42412880 |
| 45 | Obstructive sleep apnea (HP:0002870) | 2.41643517 |
| 46 | Action tremor (HP:0002345) | 2.38484629 |
| 47 | Abnormal ciliary motility (HP:0012262) | 2.37200750 |
| 48 | Generalized tonic-clonic seizures (HP:0002069) | 2.37062258 |
| 49 | Spastic gait (HP:0002064) | 2.36630490 |
| 50 | Aplasia/Hypoplasia of the lens (HP:0008063) | 2.35419134 |
| 51 | Gait imbalance (HP:0002141) | 2.35135383 |
| 52 | Gaze-evoked nystagmus (HP:0000640) | 2.34877543 |
| 53 | Poor suck (HP:0002033) | 2.32806771 |
| 54 | Abnormality of the fovea (HP:0000493) | 2.32764117 |
| 55 | Flat cornea (HP:0007720) | 2.29259686 |
| 56 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.29153653 |
| 57 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.28956642 |
| 58 | Amyotrophic lateral sclerosis (HP:0007354) | 2.27003420 |
| 59 | Double outlet right ventricle (HP:0001719) | 2.26122646 |
| 60 | Congenital malformation of the right heart (HP:0011723) | 2.26122646 |
| 61 | Hepatoblastoma (HP:0002884) | 2.25374282 |
| 62 | Pachygyria (HP:0001302) | 2.25140809 |
| 63 | Sleep apnea (HP:0010535) | 2.22094318 |
| 64 | Overriding aorta (HP:0002623) | 2.21815997 |
| 65 | Abnormality of the intervertebral disk (HP:0005108) | 2.21625255 |
| 66 | Pancreatic fibrosis (HP:0100732) | 2.20973753 |
| 67 | Congenital primary aphakia (HP:0007707) | 2.20272886 |
| 68 | Abnormality of the labia minora (HP:0012880) | 2.19739115 |
| 69 | Renal duplication (HP:0000075) | 2.18195227 |
| 70 | Lissencephaly (HP:0001339) | 2.17740048 |
| 71 | Fetal akinesia sequence (HP:0001989) | 2.16460681 |
| 72 | Growth hormone deficiency (HP:0000824) | 2.14797113 |
| 73 | Nephronophthisis (HP:0000090) | 2.14304945 |
| 74 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.14088571 |
| 75 | Oligodactyly (hands) (HP:0001180) | 2.13645081 |
| 76 | Unilateral renal agenesis (HP:0000122) | 2.12857196 |
| 77 | Abnormality of the pulmonary veins (HP:0011718) | 2.12419916 |
| 78 | Supernumerary spleens (HP:0009799) | 2.10426519 |
| 79 | Status epilepticus (HP:0002133) | 2.10321871 |
| 80 | Abnormality of binocular vision (HP:0011514) | 2.09082484 |
| 81 | Diplopia (HP:0000651) | 2.09082484 |
| 82 | Concave nail (HP:0001598) | 2.08659107 |
| 83 | Torticollis (HP:0000473) | 2.08301282 |
| 84 | Vaginal atresia (HP:0000148) | 2.07766457 |
| 85 | Agitation (HP:0000713) | 2.06360377 |
| 86 | Hypoplasia of the brainstem (HP:0002365) | 2.05661956 |
| 87 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.05661956 |
| 88 | Ectopic kidney (HP:0000086) | 2.05627548 |
| 89 | Parakeratosis (HP:0001036) | 2.05460003 |
| 90 | Congenital sensorineural hearing impairment (HP:0008527) | 2.05428912 |
| 91 | Genital tract atresia (HP:0001827) | 2.04343235 |
| 92 | Urinary urgency (HP:0000012) | 2.02511819 |
| 93 | Absence seizures (HP:0002121) | 2.02443856 |
| 94 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 2.01780372 |
| 95 | Hyperacusis (HP:0010780) | 2.01168193 |
| 96 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.00235218 |
| 97 | Decreased central vision (HP:0007663) | 1.99842726 |
| 98 | Hypothermia (HP:0002045) | 1.99325440 |
| 99 | Bony spicule pigmentary retinopathy (HP:0007737) | 1.98402364 |
| 100 | Postaxial foot polydactyly (HP:0001830) | 1.97059244 |
| 101 | Ankle clonus (HP:0011448) | 1.96769718 |
| 102 | Abnormality of the carotid arteries (HP:0005344) | 1.96456311 |
| 103 | Dialeptic seizures (HP:0011146) | 1.95225209 |
| 104 | Anophthalmia (HP:0000528) | 1.94396991 |
| 105 | Chronic hepatic failure (HP:0100626) | 1.94393785 |
| 106 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.93972660 |
| 107 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.93972660 |
| 108 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.93874501 |
| 109 | Broad-based gait (HP:0002136) | 1.93498223 |
| 110 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.93405172 |
| 111 | Incomplete penetrance (HP:0003829) | 1.93200632 |
| 112 | Neonatal hypoglycemia (HP:0001998) | 1.92930170 |
| 113 | Abnormality of incisor morphology (HP:0011063) | 1.92695343 |
| 114 | Preaxial hand polydactyly (HP:0001177) | 1.92559454 |
| 115 | Poor coordination (HP:0002370) | 1.91975435 |
| 116 | Prolonged QT interval (HP:0001657) | 1.90078069 |
| 117 | Anterior segment dysgenesis (HP:0007700) | 1.89213078 |
| 118 | Congenital stationary night blindness (HP:0007642) | 1.88177291 |
| 119 | Spastic tetraplegia (HP:0002510) | 1.87889382 |
| 120 | Aplasia of the musculature (HP:0100854) | 1.87528515 |
| 121 | Increased corneal curvature (HP:0100692) | 1.87038797 |
| 122 | Keratoconus (HP:0000563) | 1.87038797 |
| 123 | Absent eyebrow (HP:0002223) | 1.86741809 |
| 124 | Optic neuritis (HP:0100653) | 1.86371020 |
| 125 | Retrobulbar optic neuritis (HP:0100654) | 1.86371020 |
| 126 | Abnormality of the incisor (HP:0000676) | 1.85497352 |
| 127 | Diastasis recti (HP:0001540) | 1.84678415 |
| 128 | Renal Fanconi syndrome (HP:0001994) | 1.84255940 |
| 129 | Neurofibrillary tangles (HP:0002185) | 1.82941522 |
| 130 | Insomnia (HP:0100785) | 1.82827460 |
| 131 | Depression (HP:0000716) | 1.82596440 |
| 132 | Visual hallucinations (HP:0002367) | 1.82170761 |
| 133 | Chromsome breakage (HP:0040012) | 1.81741314 |
| 134 | Spina bifida occulta (HP:0003298) | 1.80481637 |
| 135 | Myotonia (HP:0002486) | 1.79717514 |
| 136 | Specific learning disability (HP:0001328) | 1.79637548 |
| 137 | Abolished electroretinogram (ERG) (HP:0000550) | 1.79153953 |
| 138 | Absent septum pellucidum (HP:0001331) | 1.78109820 |
| 139 | Abnormality of midbrain morphology (HP:0002418) | 1.77874763 |
| 140 | Molar tooth sign on MRI (HP:0002419) | 1.77874763 |
| 141 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 1.76342014 |
| 142 | Pendular nystagmus (HP:0012043) | 1.75725641 |
| 143 | Anxiety (HP:0000739) | 1.75449768 |
| 144 | Focal dystonia (HP:0004373) | 1.75449099 |
| 145 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.75394170 |
| 146 | Postaxial hand polydactyly (HP:0001162) | 1.74404168 |
| 147 | Cerebral hypomyelination (HP:0006808) | 1.74057736 |
| 148 | Choroideremia (HP:0001139) | 1.72990701 |
| 149 | Abnormal social behavior (HP:0012433) | 1.72484548 |
| 150 | Impaired social interactions (HP:0000735) | 1.72484548 |
| 151 | Hemiparesis (HP:0001269) | 1.70090587 |
| 152 | Occipital encephalocele (HP:0002085) | 1.69939146 |
| 153 | Failure to thrive in infancy (HP:0001531) | 1.69237406 |
| 154 | Bradycardia (HP:0001662) | 1.68384016 |
| 155 | Abnormality of the septum pellucidum (HP:0007375) | 1.66942999 |
| 156 | Intellectual disability, moderate (HP:0002342) | 1.66821808 |
| 157 | Absent speech (HP:0001344) | 1.66677776 |
| 158 | Tented upper lip vermilion (HP:0010804) | 1.66563611 |
| 159 | Hypoplasia of the corpus callosum (HP:0002079) | 1.66097515 |
| 160 | Anencephaly (HP:0002323) | 1.65548456 |
| 161 | Cutaneous finger syndactyly (HP:0010554) | 1.65395520 |
| 162 | Abnormality of the diencephalon (HP:0010662) | 1.65392376 |
| 163 | Intention tremor (HP:0002080) | 1.64744339 |
| 164 | Restlessness (HP:0000711) | 1.64682549 |
| 165 | Increased hepatocellular lipid droplets (HP:0006565) | 1.64431080 |
| 166 | Abnormality of the renal medulla (HP:0100957) | 1.64316512 |
| 167 | Oligodactyly (HP:0012165) | 1.63428707 |
| 168 | Esotropia (HP:0000565) | 1.62854145 |
| 169 | Abnormality of the aortic arch (HP:0012303) | 1.62821436 |
| 170 | Abnormality of cells of the erythroid lineage (HP:0012130) | 1.62200130 |
| 171 | Epileptiform EEG discharges (HP:0011182) | 1.61424530 |
| 172 | Dysmetria (HP:0001310) | 1.60952448 |
| 173 | Abnormal drinking behavior (HP:0030082) | 1.59829361 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SIK3 | 5.07471531 |
| 2 | CASK | 4.28739832 |
| 3 | NTRK2 | 2.64457549 |
| 4 | LIMK1 | 2.63619929 |
| 5 | ERBB3 | 2.57564494 |
| 6 | MAP2K7 | 2.51558755 |
| 7 | MAP3K9 | 2.31671481 |
| 8 | CAMKK1 | 2.27457373 |
| 9 | MARK1 | 2.22325848 |
| 10 | EPHA3 | 2.21620699 |
| 11 | EPHB2 | 2.18787276 |
| 12 | AKT3 | 2.18200564 |
| 13 | TNIK | 2.16056042 |
| 14 | YES1 | 2.10752583 |
| 15 | DAPK2 | 2.08146928 |
| 16 | MAPK13 | 2.07647791 |
| 17 | INSRR | 2.07320177 |
| 18 | BRD4 | 1.96820942 |
| 19 | KSR1 | 1.89282905 |
| 20 | BCR | 1.80956831 |
| 21 | PRPF4B | 1.69944429 |
| 22 | CDC42BPA | 1.65101630 |
| 23 | SGK2 | 1.64474554 |
| 24 | IRAK2 | 1.64165988 |
| 25 | CDK8 | 1.55694510 |
| 26 | NEK6 | 1.54206345 |
| 27 | IRAK4 | 1.50555090 |
| 28 | SGK494 | 1.47193910 |
| 29 | SGK223 | 1.47193910 |
| 30 | SRPK1 | 1.47125457 |
| 31 | STK16 | 1.41560828 |
| 32 | MAP3K14 | 1.38539413 |
| 33 | BMPR2 | 1.35507011 |
| 34 | MAP3K11 | 1.33498932 |
| 35 | UHMK1 | 1.32478375 |
| 36 | MINK1 | 1.32434912 |
| 37 | PHKG2 | 1.31898064 |
| 38 | PHKG1 | 1.31898064 |
| 39 | FGFR2 | 1.31335192 |
| 40 | EPHA4 | 1.31233567 |
| 41 | SIK2 | 1.29284667 |
| 42 | DYRK1A | 1.28822486 |
| 43 | PNCK | 1.27105055 |
| 44 | MARK3 | 1.25914823 |
| 45 | MAP3K6 | 1.22276757 |
| 46 | NTRK3 | 1.21676010 |
| 47 | PAK3 | 1.20991385 |
| 48 | WNK4 | 1.20592835 |
| 49 | MAP3K12 | 1.08947369 |
| 50 | MAP3K4 | 1.07133299 |
| 51 | WNK3 | 1.06407049 |
| 52 | DYRK1B | 1.06222057 |
| 53 | GRK1 | 1.05986003 |
| 54 | DYRK2 | 1.05840165 |
| 55 | MARK2 | 1.01817442 |
| 56 | CAMK1 | 0.94853056 |
| 57 | CSNK1G2 | 0.94372018 |
| 58 | ADRBK2 | 0.93180944 |
| 59 | ERBB2 | 0.91942928 |
| 60 | WNK1 | 0.90180557 |
| 61 | TXK | 0.86918996 |
| 62 | STK24 | 0.86693893 |
| 63 | STK11 | 0.86153073 |
| 64 | PRKCG | 0.85625732 |
| 65 | NTRK1 | 0.82995775 |
| 66 | ICK | 0.82660901 |
| 67 | CDK19 | 0.81708074 |
| 68 | IRAK1 | 0.80039453 |
| 69 | CDK14 | 0.78429652 |
| 70 | BMPR1B | 0.77842287 |
| 71 | MKNK1 | 0.77313221 |
| 72 | CDK15 | 0.77214476 |
| 73 | PRKCH | 0.74050435 |
| 74 | STK38L | 0.73404873 |
| 75 | SGK3 | 0.71861706 |
| 76 | CDK11A | 0.71321165 |
| 77 | CAMK4 | 0.71154811 |
| 78 | CDK3 | 0.70764542 |
| 79 | MAPK15 | 0.69774297 |
| 80 | CHUK | 0.68267280 |
| 81 | PRKD3 | 0.67796331 |
| 82 | RPS6KA2 | 0.67717700 |
| 83 | FGFR3 | 0.65596455 |
| 84 | VRK1 | 0.65359355 |
| 85 | PAK6 | 0.64615500 |
| 86 | CSNK1E | 0.63900133 |
| 87 | PRKCE | 0.63542812 |
| 88 | CSNK1A1L | 0.61267311 |
| 89 | ROCK2 | 0.61245255 |
| 90 | CSNK1G3 | 0.60063649 |
| 91 | PLK2 | 0.59447853 |
| 92 | RPS6KA6 | 0.57209784 |
| 93 | PINK1 | 0.56407221 |
| 94 | RPS6KL1 | 0.55299061 |
| 95 | RPS6KC1 | 0.55299061 |
| 96 | PKN1 | 0.53999455 |
| 97 | IKBKE | 0.53864952 |
| 98 | OXSR1 | 0.53742720 |
| 99 | ROCK1 | 0.53314688 |
| 100 | BRAF | 0.50910704 |
| 101 | TAOK2 | 0.48883294 |
| 102 | RIPK4 | 0.48577157 |
| 103 | CDK5 | 0.48107622 |
| 104 | PRKACA | 0.47897671 |
| 105 | RPS6KB1 | 0.47640225 |
| 106 | PRKAA1 | 0.47479331 |
| 107 | CAMK1D | 0.47403541 |
| 108 | STK39 | 0.45922890 |
| 109 | RPS6KA3 | 0.44958851 |
| 110 | ZAK | 0.44695781 |
| 111 | BRSK1 | 0.44547348 |
| 112 | CCNB1 | 0.43324140 |
| 113 | SGK1 | 0.42701777 |
| 114 | CAMK2A | 0.41357015 |
| 115 | CSNK1G1 | 0.40663123 |
| 116 | PBK | 0.39714101 |
| 117 | TIE1 | 0.38430610 |
| 118 | MKNK2 | 0.37942612 |
| 119 | MAPK12 | 0.37894851 |
| 120 | CAMKK2 | 0.37590219 |
| 121 | PRKDC | 0.37122064 |
| 122 | ABL2 | 0.36710536 |
| 123 | TLK1 | 0.36522171 |
| 124 | TYRO3 | 0.36063614 |
| 125 | MAPK7 | 0.35963210 |
| 126 | PLK3 | 0.35377311 |
| 127 | PRKG1 | 0.34894560 |
| 128 | EIF2AK2 | 0.34789602 |
| 129 | SIK1 | 0.33347745 |
| 130 | HIPK2 | 0.32396873 |
| 131 | CDK18 | 0.32246553 |
| 132 | GSK3B | 0.32092030 |
| 133 | MAPK9 | 0.31744066 |
| 134 | PRKCZ | 0.31653255 |
| 135 | CSNK1A1 | 0.31508716 |
| 136 | PDK2 | 0.31401700 |
| 137 | IRAK3 | 0.31275632 |
| 138 | AURKA | 0.31180420 |
| 139 | DYRK3 | 0.30086671 |
| 140 | MAPK8 | 0.29984206 |
| 141 | MAP2K4 | 0.29865755 |
| 142 | MUSK | 0.29474149 |
| 143 | RPS6KA1 | 0.29229568 |
| 144 | AKT2 | 0.27949377 |
| 145 | CAMK1G | 0.27136740 |
| 146 | PRKCD | 0.25354899 |
| 147 | PRKCQ | 0.24807182 |
| 148 | PLK1 | 0.24769001 |
| 149 | MAPK14 | 0.24462225 |
| 150 | AKT1 | 0.24437195 |
| 151 | CDK2 | 0.24188079 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.37817452 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.75221977 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.60238762 |
| 4 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.58798568 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.58128657 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.25212897 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.23548951 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.18858769 |
| 9 | GABAergic synapse_Homo sapiens_hsa04727 | 2.12527800 |
| 10 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.11060143 |
| 11 | Axon guidance_Homo sapiens_hsa04360 | 2.06551975 |
| 12 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.01077281 |
| 13 | Taste transduction_Homo sapiens_hsa04742 | 1.92749700 |
| 14 | Alzheimers disease_Homo sapiens_hsa05010 | 1.89433708 |
| 15 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.85205199 |
| 16 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.71595415 |
| 17 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.69940861 |
| 18 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.66486579 |
| 19 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.64627354 |
| 20 | Long-term depression_Homo sapiens_hsa04730 | 1.62067242 |
| 21 | Huntingtons disease_Homo sapiens_hsa05016 | 1.62041414 |
| 22 | Ribosome_Homo sapiens_hsa03010 | 1.59963343 |
| 23 | Olfactory transduction_Homo sapiens_hsa04740 | 1.54596455 |
| 24 | Phototransduction_Homo sapiens_hsa04744 | 1.54514439 |
| 25 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.51637923 |
| 26 | Insulin secretion_Homo sapiens_hsa04911 | 1.42716072 |
| 27 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.37826787 |
| 28 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.36953203 |
| 29 | Circadian rhythm_Homo sapiens_hsa04710 | 1.34181257 |
| 30 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.31146852 |
| 31 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.30112264 |
| 32 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.27397289 |
| 33 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.27101296 |
| 34 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.22695664 |
| 35 | Melanogenesis_Homo sapiens_hsa04916 | 1.17425291 |
| 36 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.17243493 |
| 37 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.15854487 |
| 38 | Long-term potentiation_Homo sapiens_hsa04720 | 1.15845686 |
| 39 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.14743105 |
| 40 | Basal transcription factors_Homo sapiens_hsa03022 | 1.09814749 |
| 41 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.08975755 |
| 42 | Alcoholism_Homo sapiens_hsa05034 | 1.08552533 |
| 43 | Salivary secretion_Homo sapiens_hsa04970 | 1.04589073 |
| 44 | Cocaine addiction_Homo sapiens_hsa05030 | 1.02802155 |
| 45 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.01241670 |
| 46 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.00622806 |
| 47 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.97463774 |
| 48 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.97261368 |
| 49 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.93943000 |
| 50 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.93679947 |
| 51 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.92561091 |
| 52 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.91587991 |
| 53 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.89205705 |
| 54 | Allograft rejection_Homo sapiens_hsa05330 | 0.89000219 |
| 55 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.86424933 |
| 56 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.83010265 |
| 57 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.82723891 |
| 58 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.81625401 |
| 59 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.80999507 |
| 60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.80489217 |
| 61 | Endometrial cancer_Homo sapiens_hsa05213 | 0.78584817 |
| 62 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.78332856 |
| 63 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.78144929 |
| 64 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.78000869 |
| 65 | Gap junction_Homo sapiens_hsa04540 | 0.76301661 |
| 66 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.75641245 |
| 67 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.74837006 |
| 68 | Colorectal cancer_Homo sapiens_hsa05210 | 0.73993597 |
| 69 | Bile secretion_Homo sapiens_hsa04976 | 0.71897975 |
| 70 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.71355142 |
| 71 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.70813281 |
| 72 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.70288758 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.69917166 |
| 74 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.69526202 |
| 75 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.69367954 |
| 76 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.68795476 |
| 77 | Phagosome_Homo sapiens_hsa04145 | 0.68356280 |
| 78 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.66410454 |
| 79 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.65524167 |
| 80 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.63984708 |
| 81 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.63915982 |
| 82 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.60994017 |
| 83 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.60300011 |
| 84 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.60178173 |
| 85 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.60018832 |
| 86 | Renin secretion_Homo sapiens_hsa04924 | 0.59705292 |
| 87 | Melanoma_Homo sapiens_hsa05218 | 0.59174165 |
| 88 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.58613068 |
| 89 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.58470129 |
| 90 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.57950187 |
| 91 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.56990602 |
| 92 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.56214245 |
| 93 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.55560959 |
| 94 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.54684021 |
| 95 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.54664946 |
| 96 | Spliceosome_Homo sapiens_hsa03040 | 0.54340709 |
| 97 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.53396833 |
| 98 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.53293906 |
| 99 | Protein export_Homo sapiens_hsa03060 | 0.53210107 |
| 100 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.51040615 |
| 101 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.49570527 |
| 102 | Salmonella infection_Homo sapiens_hsa05132 | 0.49380327 |
| 103 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.47759413 |
| 104 | Glioma_Homo sapiens_hsa05214 | 0.46769034 |
| 105 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.46498186 |
| 106 | Leishmaniasis_Homo sapiens_hsa05140 | 0.46083859 |
| 107 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.45961466 |
| 108 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.44321618 |
| 109 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.42485347 |
| 110 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.42201774 |
| 111 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.40854267 |
| 112 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.40829773 |
| 113 | Tuberculosis_Homo sapiens_hsa05152 | 0.40478803 |
| 114 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.40334458 |
| 115 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39944662 |
| 116 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.39745730 |
| 117 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.39207877 |
| 118 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.38717244 |
| 119 | Prion diseases_Homo sapiens_hsa05020 | 0.38635163 |
| 120 | Measles_Homo sapiens_hsa05162 | 0.38412827 |
| 121 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.37903884 |
| 122 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.36919763 |
| 123 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.36791310 |
| 124 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.35974088 |
| 125 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.35859412 |
| 126 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.34958021 |
| 127 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.34696573 |
| 128 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.33865239 |
| 129 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.32631179 |
| 130 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.31833972 |
| 131 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.31786225 |
| 132 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29800516 |
| 133 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.24266721 |
| 134 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.23546691 |
| 135 | Endocytosis_Homo sapiens_hsa04144 | 0.20926340 |
| 136 | RNA degradation_Homo sapiens_hsa03018 | 0.20447650 |
| 137 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.18734848 |

