BARX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homeobox transcription factor family. A highly related protein in mouse has been shown to influence cellular processes that control cell adhesion and remodeling of the actin cytoskeleton in myoblast fusion and chondrogenesis. The encoded protein may also play a role in cancer progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.59733134
2establishment of skin barrier (GO:0061436)9.21001141
3regulation of water loss via skin (GO:0033561)8.34589933
4peptide cross-linking (GO:0018149)6.45179123
5intermediate filament organization (GO:0045109)6.22802457
6virion attachment to host cell (GO:0019062)6.03532692
7adhesion of symbiont to host cell (GO:0044650)6.03532692
8keratinocyte differentiation (GO:0030216)6.01145229
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.74330424
10multicellular organismal water homeostasis (GO:0050891)5.68997856
11epidermis development (GO:0008544)5.33107128
12adhesion of symbiont to host (GO:0044406)4.91485145
13fatty acid elongation (GO:0030497)4.80235334
14epidermal cell differentiation (GO:0009913)4.77199710
15water homeostasis (GO:0030104)4.68615652
16keratinocyte development (GO:0003334)4.60641730
17skin morphogenesis (GO:0043589)4.30936745
18intermediate filament cytoskeleton organization (GO:0045104)4.23384024
19intermediate filament-based process (GO:0045103)4.17553359
20ectoderm development (GO:0007398)4.17542698
21phosphatidylserine acyl-chain remodeling (GO:0036150)4.00549880
22multicellular organism reproduction (GO:0032504)4.00463601
23piRNA metabolic process (GO:0034587)3.94049739
24long-chain fatty acid biosynthetic process (GO:0042759)3.85611151
25citrulline biosynthetic process (GO:0019240)3.75277134
26tooth mineralization (GO:0034505)3.73070476
27L-fucose catabolic process (GO:0042355)3.72406602
28fucose catabolic process (GO:0019317)3.72406602
29L-fucose metabolic process (GO:0042354)3.72406602
30negative regulation of keratinocyte proliferation (GO:0010839)3.71056249
31DNA methylation involved in gamete generation (GO:0043046)3.60139929
32cardiac right ventricle morphogenesis (GO:0003215)3.56907515
33skin development (GO:0043588)3.55522735
34response to pheromone (GO:0019236)3.55024095
35keratinocyte proliferation (GO:0043616)3.53364341
36regulation of skeletal muscle contraction (GO:0014819)3.51863935
37hair follicle morphogenesis (GO:0031069)3.51727376
38oocyte development (GO:0048599)3.51693252
39muscle filament sliding (GO:0030049)3.49947153
40actin-myosin filament sliding (GO:0033275)3.49947153
41cell-substrate junction assembly (GO:0007044)3.49915243
42behavioral response to nicotine (GO:0035095)3.39683103
43long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.38314442
44glycine transport (GO:0015816)3.31479046
45positive regulation of prostaglandin secretion (GO:0032308)3.28294125
46regulation of guanylate cyclase activity (GO:0031282)3.28069444
47auditory receptor cell stereocilium organization (GO:0060088)3.25310444
48long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.24587702
49cornea development in camera-type eye (GO:0061303)3.23510593
50skeletal muscle contraction (GO:0003009)3.21914112
51axoneme assembly (GO:0035082)3.21473401
52phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.18600751
53arginine catabolic process (GO:0006527)3.18552892
54actin-mediated cell contraction (GO:0070252)3.17457315
55establishment of planar polarity (GO:0001736)3.11918858
56establishment of tissue polarity (GO:0007164)3.11918858
57plasma membrane repair (GO:0001778)3.11262673
58protein polyglutamylation (GO:0018095)3.08998094
59skeletal muscle fiber development (GO:0048741)3.07771254
60positive regulation of fatty acid transport (GO:2000193)3.06362659
61intestinal absorption (GO:0050892)3.03329893
62regulation of cardioblast differentiation (GO:0051890)3.01202697
63fatty-acyl-CoA biosynthetic process (GO:0046949)3.00421148
64positive regulation of guanylate cyclase activity (GO:0031284)2.99985102
65ventricular cardiac muscle cell action potential (GO:0086005)2.99689782
66positive regulation of icosanoid secretion (GO:0032305)2.98990603
67pattern specification involved in kidney development (GO:0061004)2.97955938
68molting cycle process (GO:0022404)2.96035749
69hair cycle process (GO:0022405)2.96035749
70nonribosomal peptide biosynthetic process (GO:0019184)2.95736921
71regulation of keratinocyte differentiation (GO:0045616)2.95406732
72nitric oxide biosynthetic process (GO:0006809)2.94628549
73photoreceptor cell maintenance (GO:0045494)2.91880786
74skeletal muscle adaptation (GO:0043501)2.91477777
75cell wall macromolecule metabolic process (GO:0044036)2.90307236
76cell wall macromolecule catabolic process (GO:0016998)2.90307236
77glutathione biosynthetic process (GO:0006750)2.88674762
78arginine metabolic process (GO:0006525)2.88424684
79negative regulation of cell fate specification (GO:0009996)2.87936625
80atrioventricular valve morphogenesis (GO:0003181)2.87030716
81regulation of skeletal muscle cell differentiation (GO:2001014)2.86900943
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.86840962
83angiotensin maturation (GO:0002003)2.86756999
84muscle cell fate commitment (GO:0042693)2.85967587
85fatty-acyl-CoA metabolic process (GO:0035337)2.85002799
86regulation of hair follicle development (GO:0051797)2.82489733
87regulation of ruffle assembly (GO:1900027)2.81580351
88negative regulation of epidermal cell differentiation (GO:0045605)2.78430529
89cellular ketone body metabolic process (GO:0046950)2.78052172
90negative regulation of epidermis development (GO:0045683)2.77694908
91reproduction (GO:0000003)2.77651821
92positive regulation of epidermis development (GO:0045684)2.75920396
93transepithelial transport (GO:0070633)2.73960315
94epithelial cell-cell adhesion (GO:0090136)2.73094750
95vitamin A metabolic process (GO:0006776)2.72685317
96regulation of epidermis development (GO:0045682)2.71542967
97phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.70119746
98acyl-CoA biosynthetic process (GO:0071616)2.70078272
99thioester biosynthetic process (GO:0035384)2.70078272
100negative regulation of cell fate commitment (GO:0010454)2.69833052
101one-carbon compound transport (GO:0019755)2.69492680
102phosphatidylcholine acyl-chain remodeling (GO:0036151)2.69200736
103sulfur compound transport (GO:0072348)2.69026588
104post-embryonic morphogenesis (GO:0009886)2.68219109
105actin filament-based movement (GO:0030048)2.67858895
106positive regulation of defense response to virus by host (GO:0002230)2.67373525
107hair follicle development (GO:0001942)2.63664933
108regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62892991
109epithelial cilium movement (GO:0003351)2.60855548
110regulation of keratinocyte proliferation (GO:0010837)2.59789638
111intestinal epithelial cell development (GO:0060576)2.59604040
112epithelium development (GO:0060429)2.59556634
113positive regulation of hair cycle (GO:0042635)2.57056416
114positive regulation of hair follicle development (GO:0051798)2.57056416
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56844035
116quinone biosynthetic process (GO:1901663)2.56387436
117negative regulation of leukocyte chemotaxis (GO:0002689)2.55776220
118regulation of hair cycle (GO:0042634)2.53963157
119ephrin receptor signaling pathway (GO:0048013)2.53779504
120single fertilization (GO:0007338)2.53656507
121planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53502630
122cilium movement (GO:0003341)2.52833712
123regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.52392604
124creatine metabolic process (GO:0006600)2.51369050
125negative regulation of organelle assembly (GO:1902116)2.51013514
126axonemal dynein complex assembly (GO:0070286)2.50852916
127polarized epithelial cell differentiation (GO:0030859)2.50779050
128inner ear receptor cell differentiation (GO:0060113)2.50431907
129sarcoplasmic reticulum calcium ion transport (GO:0070296)2.49954455
130DNA deamination (GO:0045006)2.49695402
131detection of light stimulus involved in sensory perception (GO:0050962)2.48976673
132detection of light stimulus involved in visual perception (GO:0050908)2.48976673
133calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.48925502
134auditory receptor cell differentiation (GO:0042491)2.48244354
135regulation of transforming growth factor beta2 production (GO:0032909)2.48241093
136fucosylation (GO:0036065)2.47915326
137regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.46134424
138lung secretory cell differentiation (GO:0061140)2.45804675
139ketone body metabolic process (GO:1902224)2.45665297
140response to food (GO:0032094)2.45588547
141sperm motility (GO:0030317)2.44446491
142hormone catabolic process (GO:0042447)2.44018976
143interferon-gamma secretion (GO:0072643)2.43725047
144regulation of meiosis I (GO:0060631)2.43501799
145positive regulation of mitochondrial membrane permeability (GO:0035794)2.42819332
146regulation of p38MAPK cascade (GO:1900744)2.41816812
147lymph vessel development (GO:0001945)2.40526715
148phosphatidylserine metabolic process (GO:0006658)2.40130981
149regulation of cell proliferation involved in kidney development (GO:1901722)2.40109113
150positive regulation of keratinocyte differentiation (GO:0045618)2.39960130
151ubiquinone biosynthetic process (GO:0006744)2.39783520
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.38626203
153positive regulation of p38MAPK cascade (GO:1900745)2.38579782
154sympathetic nervous system development (GO:0048485)2.38399079
155norepinephrine metabolic process (GO:0042415)2.38363500
156regulation of acrosome reaction (GO:0060046)2.37419496
157phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37379232
158myotube cell development (GO:0014904)2.37183815
159negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37157039
160regulation of epidermal cell differentiation (GO:0045604)2.36990101
161positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.36243517
162positive regulation of epidermal cell differentiation (GO:0045606)2.36196525
163regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.35590703
164positive regulation of meiotic cell cycle (GO:0051446)2.35286922
165odontogenesis (GO:0042476)2.34949360
166regulation of hippo signaling (GO:0035330)2.34593486
167intestinal cholesterol absorption (GO:0030299)2.33254172
168odontogenesis of dentin-containing tooth (GO:0042475)2.33161064
169molting cycle (GO:0042303)13.0702982
170hair cycle (GO:0042633)13.0702982
171keratinization (GO:0031424)12.1391113
172hemidesmosome assembly (GO:0031581)10.2730908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53915641
2VDR_22108803_ChIP-Seq_LS180_Human3.22439752
3EZH2_22144423_ChIP-Seq_EOC_Human3.20750730
4ZNF274_21170338_ChIP-Seq_K562_Hela3.02423149
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.51661364
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.44688423
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.42559835
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38673688
9ZNF263_19887448_ChIP-Seq_K562_Human2.33458162
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.32507510
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.19237914
12* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.16965370
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12136699
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02790586
15TP63_17297297_ChIP-ChIP_HaCaT_Human12.0608725
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.87543146
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.84475116
18ERA_21632823_ChIP-Seq_H3396_Human1.77099558
19* CBX2_27304074_Chip-Seq_ESCs_Mouse1.70420258
20P53_21459846_ChIP-Seq_SAOS-2_Human1.68255922
21AR_21572438_ChIP-Seq_LNCaP_Human1.67303417
22E2F1_20622854_ChIP-Seq_HELA_Human1.65542162
23* GATA3_21878914_ChIP-Seq_MCF-7_Human1.61833100
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59773999
25HOXB7_26014856_ChIP-Seq_BT474_Human1.59184673
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58011963
27* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56438576
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54494179
29RACK7_27058665_Chip-Seq_MCF-7_Human1.54378120
30* FOXO3_23340844_ChIP-Seq_DLD1_Human1.53252490
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52664448
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50366936
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50366936
34SOX2_20726797_ChIP-Seq_SW620_Human1.50290512
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47979400
36AR_20517297_ChIP-Seq_VCAP_Human1.47744203
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47700954
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45395667
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.45395667
40* TAF2_19829295_ChIP-Seq_ESCs_Human1.44490342
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.44003274
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41452490
43NCOR_22424771_ChIP-Seq_293T_Human1.40850602
44BCL6_27268052_Chip-Seq_Bcells_Human1.40308686
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.38910145
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38686437
47* KLF5_25053715_ChIP-Seq_YYC3_Human1.38395179
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.36939582
49MYC_19829295_ChIP-Seq_ESCs_Human1.35931104
50CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.35828916
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35395570
52OCT4_20526341_ChIP-Seq_ESCs_Human1.33983531
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33490008
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.32516190
55RAC3_21632823_ChIP-Seq_H3396_Human1.32148937
56BCOR_27268052_Chip-Seq_Bcells_Human1.32105250
57CTCF_27219007_Chip-Seq_Bcells_Human1.32019402
58* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31880646
59* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29181449
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28899609
61BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28634702
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.27647328
63PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27361364
64P68_20966046_ChIP-Seq_HELA_Human1.27146609
65TP63_23658742_ChIP-Seq_EP156T_Human1.26862641
66STAT1_20625510_ChIP-Seq_HELA_Human1.26716270
67ER_23166858_ChIP-Seq_MCF-7_Human1.26622533
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26159754
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.25851403
70CJUN_26792858_Chip-Seq_BT549_Human1.25705074
71* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24746994
72P300_27268052_Chip-Seq_Bcells_Human1.24697068
73* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24565461
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24231328
75* TP63_22573176_ChIP-Seq_HFKS_Human1.24099972
76PHF8_20622854_ChIP-Seq_HELA_Human1.23748441
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23743046
78ERG_20517297_ChIP-Seq_VCAP_Human1.23543908
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.22936079
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.21958808
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21426076
82* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.20997972
83* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.20997972
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.20680080
85* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19577401
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18365839
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18201104
88GATA4_25053715_ChIP-Seq_YYC3_Human1.14575703
89* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12499262
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.11746581
91EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10844742
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10554066
93* GATA3_24758297_ChIP-Seq_MCF-7_Human1.10323862
94* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09610071
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08681440
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08470333
97AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08337834
98WDR5_24793694_ChIP-Seq_LNCAP_Human1.07688747
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.07603827
100CBP_20019798_ChIP-Seq_JUKART_Human1.07203712
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07203712
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07108901
103AHR_22903824_ChIP-Seq_MCF-7_Human1.07100152
104SMC4_20622854_ChIP-Seq_HELA_Human1.06188709
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05959673
106CLOCK_20551151_ChIP-Seq_293T_Human1.05878982
107ATF3_27146783_Chip-Seq_COLON_Human1.05678465
108* CTCF_20526341_ChIP-Seq_ESCs_Human1.05397066
109TCF4_18268006_ChIP-ChIP_LS174T_Human1.05264450
110* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04343671
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.02909438
112* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02426082
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02284420
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02234257
115GATA6_25053715_ChIP-Seq_YYC3_Human1.01980812
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01001968
117GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00650206
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00258882
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99887043
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99887043
121* TP53_20018659_ChIP-ChIP_R1E_Mouse0.99054918
122TP53_22573176_ChIP-Seq_HFKS_Human0.99020743
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98815306
124DROSHA_22980978_ChIP-Seq_HELA_Human0.97494872
125TCF4_22108803_ChIP-Seq_LS180_Human0.97482145
126P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97441971
127* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96637546
128STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95981301
129TP53_18474530_ChIP-ChIP_U2OS_Human0.95360660
130* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95122414
131RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94727448
132FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94520415
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94173945
134EGR1_19032775_ChIP-ChIP_M12_Human0.93368099
135FOXH1_21741376_ChIP-Seq_EPCs_Human0.93113210
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.92180290
137SA1_27219007_Chip-Seq_Bcells_Human0.91351733
138* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90385284
139GATA6_21074721_ChIP-Seq_CACO-2_Human0.89951003
140KDM2B_26808549_Chip-Seq_K562_Human0.89945552
141* RXR_22108803_ChIP-Seq_LS180_Human0.88784028
142* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88686528
143* UBF1/2_26484160_Chip-Seq_HMECs_Human0.87996504
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86161167
145LXR_22292898_ChIP-Seq_THP-1_Human0.85668294
146ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84951664
147RING1B_27294783_Chip-Seq_ESCs_Mouse0.83749228
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83070294
149TBX20_22328084_ChIP-Seq_HEART_Mouse0.82982076
150TBX20_22080862_ChIP-Seq_HEART_Mouse0.82982076
151* EED_16625203_ChIP-ChIP_MESCs_Mouse0.82399624
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80803012
153* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.79332520
154FOXH1_21741376_ChIP-Seq_ESCs_Human0.79233388
155TP53_16413492_ChIP-PET_HCT116_Human0.77367837
156NANOG_20526341_ChIP-Seq_ESCs_Human0.77155747
157PIAS1_25552417_ChIP-Seq_VCAP_Human0.77039480
158SA1_27219007_Chip-Seq_ERYTHROID_Human0.76490727
159CEBPB_22108803_ChIP-Seq_LS180_Human0.72862699
160* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.72684726
161* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72625271
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72096712
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.71312658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.51570847
2MP0000579_abnormal_nail_morphology5.73376354
3MP0010234_abnormal_vibrissa_follicle5.51443358
4MP0005275_abnormal_skin_tensile5.02345998
5MP0005501_abnormal_skin_physiology4.00760624
6MP0002254_reproductive_system_inflammat3.94394444
7MP0010678_abnormal_skin_adnexa3.43314029
8MP0000383_abnormal_hair_follicle3.39808550
9* MP0002098_abnormal_vibrissa_morphology3.29293310
10MP0004043_abnormal_pH_regulation3.28527458
11MP0003705_abnormal_hypodermis_morpholog3.28033712
12MP0005377_hearing/vestibular/ear_phenot3.01070654
13MP0003878_abnormal_ear_physiology3.01070654
14MP0002060_abnormal_skin_morphology2.93353080
15MP0001216_abnormal_epidermal_layer2.88887376
16* MP0000647_abnormal_sebaceous_gland2.76274032
17MP0000762_abnormal_tongue_morphology2.67067645
18MP0000377_abnormal_hair_follicle2.63700869
19MP0000467_abnormal_esophagus_morphology2.60952945
20MP0010771_integument_phenotype2.58657523
21MP0002234_abnormal_pharynx_morphology2.46538975
22MP0003453_abnormal_keratinocyte_physiol2.27480357
23* MP0000427_abnormal_hair_cycle2.25159015
24MP0003941_abnormal_skin_development2.22603025
25MP0004381_abnormal_hair_follicle2.13178283
26MP0004947_skin_inflammation2.03370393
27MP0005451_abnormal_body_composition1.94896597
28MP0004782_abnormal_surfactant_physiolog1.82308089
29MP0009379_abnormal_foot_pigmentation1.79572033
30MP0003718_maternal_effect1.79073892
31MP0004185_abnormal_adipocyte_glucose1.78124504
32MP0001849_ear_inflammation1.74245966
33MP0008875_abnormal_xenobiotic_pharmacok1.71966903
34MP0001485_abnormal_pinna_reflex1.69597455
35MP0001243_abnormal_dermal_layer1.59713326
36MP0002653_abnormal_ependyma_morphology1.55289080
37MP0009931_abnormal_skin_appearance1.46858595
38MP0000751_myopathy1.46667746
39MP0002163_abnormal_gland_morphology1.43693816
40MP0001765_abnormal_ion_homeostasis1.42457592
41MP0002876_abnormal_thyroid_physiology1.42132097
42MP0009780_abnormal_chondrocyte_physiolo1.41753369
43MP0003566_abnormal_cell_adhesion1.40970620
44MP0000462_abnormal_digestive_system1.37248442
45MP0005410_abnormal_fertilization1.35537802
46MP0001666_abnormal_nutrient_absorption1.33428103
47MP0001873_stomach_inflammation1.31527065
48MP0005551_abnormal_eye_electrophysiolog1.30732415
49MP0008872_abnormal_physiological_respon1.28721821
50MP0001346_abnormal_lacrimal_gland1.25460667
51MP0000470_abnormal_stomach_morphology1.21235479
52* MP0000367_abnormal_coat/_hair1.21025753
53MP0001191_abnormal_skin_condition1.20635910
54MP0005075_abnormal_melanosome_morpholog1.19588989
55MP0003136_yellow_coat_color1.18147762
56MP0004264_abnormal_extraembryonic_tissu1.17679382
57MP0005670_abnormal_white_adipose1.12910250
58MP0003638_abnormal_response/metabolism_1.12840221
59MP0001968_abnormal_touch/_nociception1.12703604
60MP0009053_abnormal_anal_canal1.12385729
61MP0005085_abnormal_gallbladder_physiolo1.12364420
62* MP0002095_abnormal_skin_pigmentation1.10742805
63MP0005499_abnormal_olfactory_system1.09393586
64MP0005394_taste/olfaction_phenotype1.09393586
65MP0005409_darkened_coat_color1.08779053
66MP0000749_muscle_degeneration1.08572645
67MP0002160_abnormal_reproductive_system1.06275994
68MP0000537_abnormal_urethra_morphology1.02434008
69MP0002249_abnormal_larynx_morphology1.01117720
70MP0001188_hyperpigmentation0.99786210
71MP0003950_abnormal_plasma_membrane0.99184907
72MP0000566_synostosis0.98574486
73MP0003646_muscle_fatigue0.97516127
74MP0000733_abnormal_muscle_development0.96945528
75MP0000747_muscle_weakness0.96484637
76MP0004270_analgesia0.96287797
77MP0004145_abnormal_muscle_electrophysio0.92231504
78MP0004742_abnormal_vestibular_system0.91964326
79MP0003693_abnormal_embryo_hatching0.91531895
80MP0001851_eye_inflammation0.90323708
81MP0003755_abnormal_palate_morphology0.90287595
82MP0002282_abnormal_trachea_morphology0.89792131
83MP0001881_abnormal_mammary_gland0.88787721
84MP0005360_urolithiasis0.87117721
85MP0003385_abnormal_body_wall0.86221964
86MP0003011_delayed_dark_adaptation0.86188799
87MP0000013_abnormal_adipose_tissue0.86170635
88MP0001919_abnormal_reproductive_system0.86152392
89MP0005379_endocrine/exocrine_gland_phen0.83982507
90MP0000026_abnormal_inner_ear0.82328398
91MP0003698_abnormal_male_reproductive0.81915995
92MP0009250_abnormal_appendicular_skeleto0.81783254
93MP0002277_abnormal_respiratory_mucosa0.81310772
94MP0010030_abnormal_orbit_morphology0.81288208
95MP0001929_abnormal_gametogenesis0.80783961
96MP0003191_abnormal_cellular_cholesterol0.80279194
97MP0000627_abnormal_mammary_gland0.79422454
98MP0005365_abnormal_bile_salt0.78880291
99MP0001502_abnormal_circadian_rhythm0.78414927
100MP0005646_abnormal_pituitary_gland0.76609304
101MP0009643_abnormal_urine_homeostasis0.76453583
102MP0009384_cardiac_valve_regurgitation0.75735027
103MP0001764_abnormal_homeostasis0.75562997
104MP0005389_reproductive_system_phenotype0.74924344
105MP0000538_abnormal_urinary_bladder0.74799779
106MP0004885_abnormal_endolymph0.74564145
107MP0002210_abnormal_sex_determination0.73741368
108MP0003183_abnormal_peptide_metabolism0.73401811
109MP0005666_abnormal_adipose_tissue0.73119057
110MP0000759_abnormal_skeletal_muscle0.72666215
111MP0000230_abnormal_systemic_arterial0.71610435
112MP0004272_abnormal_basement_membrane0.71237238
113MP0002106_abnormal_muscle_physiology0.70633790
114MP0001501_abnormal_sleep_pattern0.70606713
115MP0005375_adipose_tissue_phenotype0.70445534
116MP0005636_abnormal_mineral_homeostasis0.70436409
117MP0002127_abnormal_cardiovascular_syste0.68997193
118MP0000678_abnormal_parathyroid_gland0.68777337
119MP0004147_increased_porphyrin_level0.68649085
120MP0004019_abnormal_vitamin_homeostasis0.66145563
121MP0003936_abnormal_reproductive_system0.66130808
122MP0000049_abnormal_middle_ear0.64305670
123* MP0001340_abnormal_eyelid_morphology0.63349868
124MP0008789_abnormal_olfactory_epithelium0.63059308
125MP0000750_abnormal_muscle_regeneration0.61977947
126MP0004087_abnormal_muscle_fiber0.61121453
127MP0005369_muscle_phenotype0.60090862
128MP0000015_abnormal_ear_pigmentation0.59850455
129MP0001145_abnormal_male_reproductive0.59276149
130MP0003937_abnormal_limbs/digits/tail_de0.58429531
131MP0003315_abnormal_perineum_morphology0.58392993
132MP0000653_abnormal_sex_gland0.57713148
133MP0005253_abnormal_eye_physiology0.56837749
134MP0002896_abnormal_bone_mineralization0.56457139
135MP0008438_abnormal_cutaneous_collagen0.56039944
136MP0005174_abnormal_tail_pigmentation0.55061454
137MP0004130_abnormal_muscle_cell0.54608838
138MP0000613_abnormal_salivary_gland0.53511496
139MP0005023_abnormal_wound_healing0.52941097
140MP0001784_abnormal_fluid_regulation0.52688552
141MP0005620_abnormal_muscle_contractility0.52649072
142MP0002177_abnormal_outer_ear0.52030102
143MP0000432_abnormal_head_morphology0.51643364
144MP0000003_abnormal_adipose_tissue0.51136046
145MP0002108_abnormal_muscle_morphology0.49589532
146MP0002233_abnormal_nose_morphology0.49169390
147MP0000465_gastrointestinal_hemorrhage0.47486456
148MP0005623_abnormal_meninges_morphology0.47440364
149MP0002971_abnormal_brown_adipose0.45144818
150MP0004484_altered_response_of0.44312973
151MP0001664_abnormal_digestion0.42978783
152MP0001299_abnormal_eye_distance/0.42568999
153MP0003329_amyloid_beta_deposits0.42512360
154MP0002111_abnormal_tail_morphology0.41390974
155MP0006054_spinal_hemorrhage0.40491242
156MP0004036_abnormal_muscle_relaxation0.39769597
157MP0010352_gastrointestinal_tract_polyps0.38641523

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.24215639
2Milia (HP:0001056)6.79535724
3Pili torti (HP:0003777)6.43896907
4Fragile nails (HP:0001808)6.40236930
5Onycholysis (HP:0001806)6.19412953
6Woolly hair (HP:0002224)5.92351640
7Plantar hyperkeratosis (HP:0007556)5.54118125
8Muscle fiber inclusion bodies (HP:0100299)5.40001643
9Right ventricular cardiomyopathy (HP:0011663)5.14773490
10Type 1 muscle fiber predominance (HP:0003803)5.13349739
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.07854997
12Nemaline bodies (HP:0003798)5.00117936
13Increased IgE level (HP:0003212)4.91704488
14Abnormality of nail color (HP:0100643)4.91013775
15Atrophic scars (HP:0001075)4.68477837
16Nail dystrophy (HP:0008404)4.46149324
17Decreased circulating renin level (HP:0003351)4.34801923
18Palmoplantar hyperkeratosis (HP:0000972)4.29086049
19Thick nail (HP:0001805)4.28466941
20Abnormal hair laboratory examination (HP:0003328)4.17012750
21Palmar hyperkeratosis (HP:0010765)3.98360729
22Hyperactive renin-angiotensin system (HP:0000841)3.94213495
23Congenital ichthyosiform erythroderma (HP:0007431)3.82952805
24Alopecia of scalp (HP:0002293)3.82753825
25Distal arthrogryposis (HP:0005684)3.76777565
26Hyporeflexia of lower limbs (HP:0002600)3.71285578
27Round ear (HP:0100830)3.69034533
28Myopathic facies (HP:0002058)3.55354551
29Muscle fiber splitting (HP:0003555)3.28832879
30Abnormal blistering of the skin (HP:0008066)3.26757532
31Increased connective tissue (HP:0009025)3.24134990
32Chronic bronchitis (HP:0004469)3.17328552
33Conjunctival hamartoma (HP:0100780)3.12117423
34Amelogenesis imperfecta (HP:0000705)3.10482938
35Curly hair (HP:0002212)3.06387827
36Ulnar deviation of the wrist (HP:0003049)3.03733696
37Exercise-induced myalgia (HP:0003738)3.02734685
38Distal lower limb muscle weakness (HP:0009053)3.00149574
39Brittle hair (HP:0002299)2.96046588
40Congenital stationary night blindness (HP:0007642)2.91374893
41Fragile skin (HP:0001030)2.87568625
42Pancreatic cysts (HP:0001737)2.86186500
43Erythema (HP:0010783)2.86020454
44Erythroderma (HP:0001019)2.85305189
45Furrowed tongue (HP:0000221)2.84413663
46Abnormality of renin-angiotensin system (HP:0000847)2.72550325
47Hyperkalemia (HP:0002153)2.70363097
48Cone-rod dystrophy (HP:0000548)2.69137570
49Ridged nail (HP:0001807)2.68776879
50Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.67477398
51Neck muscle weakness (HP:0000467)2.67053747
52Hypoplasia of the uterus (HP:0000013)2.63064967
53Aplasia cutis congenita (HP:0001057)2.62977153
54Fatigable weakness (HP:0003473)2.62304934
55Abnormality of the neuromuscular junction (HP:0003398)2.62304934
56Renal dysplasia (HP:0000110)2.60374046
57Hyperaldosteronism (HP:0000859)2.59172766
58Slow-growing hair (HP:0002217)2.58494503
59Abnormality of hair growth rate (HP:0011363)2.58494503
60Follicular hyperkeratosis (HP:0007502)2.57361550
61True hermaphroditism (HP:0010459)2.53402042
62Abnormality of midbrain morphology (HP:0002418)2.50544029
63Molar tooth sign on MRI (HP:0002419)2.50544029
64Calcaneovalgus deformity (HP:0001848)2.48756771
65Absent phalangeal crease (HP:0006109)2.47683971
66Chronic hepatic failure (HP:0100626)2.47101826
67Pancreatic fibrosis (HP:0100732)2.46989353
68Difficulty running (HP:0009046)2.45038672
69Oral leukoplakia (HP:0002745)2.43459843
70Pendular nystagmus (HP:0012043)2.41460862
71Deformed tarsal bones (HP:0008119)2.40607026
72Mildly elevated creatine phosphokinase (HP:0008180)2.39274583
73Type II lissencephaly (HP:0007260)2.38440195
74Absent eyelashes (HP:0000561)2.36918782
75Aplasia/hypoplasia of the uterus (HP:0008684)2.36322328
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35694238
77Septate vagina (HP:0001153)2.33612347
78Large for gestational age (HP:0001520)2.30951037
79Abnormality of the aortic arch (HP:0012303)2.27779041
80Ectropion (HP:0000656)2.27667276
81Cystic liver disease (HP:0006706)2.24142136
82Advanced eruption of teeth (HP:0006288)2.24109048
83Renal salt wasting (HP:0000127)2.23780341
84Congenital, generalized hypertrichosis (HP:0004540)2.23763437
85Ventricular tachycardia (HP:0004756)2.23044062
86Parakeratosis (HP:0001036)2.22612197
87Palmoplantar keratoderma (HP:0000982)2.22349569
88Hypokalemic alkalosis (HP:0001949)2.18426007
89Corneal erosion (HP:0200020)2.18122641
90Abnormality of skeletal muscle fiber size (HP:0012084)2.15373168
91Achilles tendon contracture (HP:0001771)2.15244825
92Conical tooth (HP:0000698)2.14960598
93Chorioretinal atrophy (HP:0000533)2.13418345
94Abnormality of the renal medulla (HP:0100957)2.11978796
95Exercise-induced muscle cramps (HP:0003710)2.11844517
96Abnormality of chloride homeostasis (HP:0011422)2.11754268
97Concave nail (HP:0001598)2.11450660
98Sparse eyelashes (HP:0000653)2.10665140
99Abnormality of the axillary hair (HP:0100134)2.10314859
100Abnormality of secondary sexual hair (HP:0009888)2.10314859
101Hypohidrosis (HP:0000966)2.09883636
102Increased variability in muscle fiber diameter (HP:0003557)2.08786912
103Duplicated collecting system (HP:0000081)2.07381002
104Sparse scalp hair (HP:0002209)2.05546516
105Nephronophthisis (HP:0000090)2.04902782
106Lip pit (HP:0100267)2.04675300
107Alkalosis (HP:0001948)2.02348230
108Hypoplastic labia majora (HP:0000059)2.01435039
109Abnormality of the renal collecting system (HP:0004742)2.01179842
110Hyperventilation (HP:0002883)1.99261294
111Sclerocornea (HP:0000647)1.99024493
112Scapular winging (HP:0003691)1.98723923
113Areflexia of lower limbs (HP:0002522)1.96911968
114Attenuation of retinal blood vessels (HP:0007843)1.96681967
115Hamartoma of the eye (HP:0010568)1.95657981
116Abnormal finger flexion creases (HP:0006143)1.95555425
117Acanthosis nigricans (HP:0000956)1.93756154
118Pterygium (HP:0001059)1.93749178
119Microretrognathia (HP:0000308)1.93549095
120Hypoplasia of dental enamel (HP:0006297)1.93458328
121Abnormality of glutamine family amino acid metabolism (HP:0010902)1.92846472
122Sudden death (HP:0001699)1.91433985
123EMG: myopathic abnormalities (HP:0003458)1.90364303
124Congenital sensorineural hearing impairment (HP:0008527)1.88890300
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.88504532
126Abnormality of the renal cortex (HP:0011035)1.88227021
127Abnormality of the Achilles tendon (HP:0005109)1.87092627
128Muscle hypertrophy of the lower extremities (HP:0008968)1.85840958
129Spinal rigidity (HP:0003306)1.84798674
130Facial shape deformation (HP:0011334)1.84181563
131Potter facies (HP:0002009)1.84181563
132Down-sloping shoulders (HP:0200021)1.82944879
133Difficulty climbing stairs (HP:0003551)1.82508415
134Occipital encephalocele (HP:0002085)1.82374203
135Bicornuate uterus (HP:0000813)1.82237294
136Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81579770
137Pruritus (HP:0000989)1.81536770
138Absent hair (HP:0002298)1.79698681
139Frequent falls (HP:0002359)1.78299671
140Natal tooth (HP:0000695)1.77952477
141Abnormality of dental color (HP:0011073)1.77656535
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.76885156
143Absent/shortened dynein arms (HP:0200106)1.76885156
144Hyperglycinuria (HP:0003108)1.76284380
145Abnormality of proline metabolism (HP:0010907)1.75810945
146Hydroxyprolinuria (HP:0003080)1.75810945
147Slender build (HP:0001533)1.75691793
148Aplasia/Hypoplasia of the patella (HP:0006498)1.74927434
149Abnormality of macular pigmentation (HP:0008002)1.74293894
150Dehydration (HP:0001944)1.74035123
151Non-midline cleft lip (HP:0100335)1.73813743
152Malignant hyperthermia (HP:0002047)1.69322005
153Esophageal atresia (HP:0002032)1.68730295
154Hip contracture (HP:0003273)1.68371807
155Bronchomalacia (HP:0002780)1.67582316
156Abnormality of the calf musculature (HP:0001430)1.66593180
157Distal lower limb amyotrophy (HP:0008944)1.64626834
158Malnutrition (HP:0004395)1.64390110
159Blepharitis (HP:0000498)1.62052277
160Cupped ribs (HP:0000887)1.61795767
161Premature rupture of membranes (HP:0001788)1.60134003
162Muscle stiffness (HP:0003552)1.59831158
163Rimmed vacuoles (HP:0003805)1.59459117
164Ventricular fibrillation (HP:0001663)1.58292077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.65705401
2NME13.49892646
3EPHA23.43066861
4MST43.23579708
5PIK3CG3.13630734
6MAP3K33.05100612
7LATS12.96762600
8MAP4K22.95032677
9EPHB12.93458121
10INSRR2.83579801
11FER2.80104511
12MST1R2.69793022
13TTN2.65366179
14TRIB32.61856908
15MAP3K22.53959587
16MAPKAPK32.38588792
17EPHB22.32956689
18TESK22.11801138
19GRK11.93250126
20MAPK151.88912183
21ACVR1B1.79635741
22TAOK11.74917204
23TAOK31.71975557
24PHKG11.70563078
25PHKG21.70563078
26ERN11.65435082
27ADRBK21.63722690
28RIPK11.58700521
29LATS21.56749580
30TLK11.53988658
31STK391.53019144
32TXK1.50065483
33NUAK11.43179120
34MET1.42146722
35MAP3K91.42084511
36PRKD31.40651816
37CAMK1D1.34693730
38BMPR1B1.32983281
39IKBKB1.32452665
40MAP3K71.32189471
41BCR1.30567939
42PTK61.29019534
43IRAK31.23233223
44VRK21.23150921
45PINK11.21725712
46FGFR11.18592222
47KSR21.18551692
48MAP2K61.15326661
49MAP3K111.14199243
50MAP3K11.13720166
51BCKDK1.12948127
52CHUK1.12540253
53STK38L1.11609910
54ZAK1.06608905
55TAF11.05293411
56TYRO31.03108957
57STK161.01788378
58PTK21.00402185
59DDR21.00365940
60EEF2K1.00345779
61NEK60.99482612
62RPS6KB20.96764257
63PIK3CA0.95795360
64GRK60.93707922
65MAPKAPK50.93695883
66MAP2K40.90267971
67EPHA30.89898230
68SIK10.88865856
69IRAK10.84525799
70STK240.83003212
71LIMK10.82804563
72MAP3K60.82482194
73BMX0.82050158
74DMPK0.76626892
75PRKCI0.75845854
76MAP2K30.75357803
77IKBKE0.75291103
78LRRK20.75134826
79TRPM70.74994228
80MAP2K10.73361028
81FGFR20.72941695
82PRKD20.71452049
83STK30.71009820
84MAPK120.69152116
85CAMK1G0.69036216
86VRK10.66902997
87STK110.66473059
88EPHA40.63220870
89RET0.62589970
90WNK40.59439351
91ICK0.58064269
92LMTK20.57162938
93PDK20.56687594
94CDK70.56626828
95IRAK20.55032299
96TAOK20.54532976
97FRK0.53683826
98CDK190.53348502
99TGFBR10.53189930
100PDK30.53021183
101PDK40.53021183
102OXSR10.52943466
103ROCK10.52908699
104PRKD10.52617299
105MAP2K20.52182154
106PRKG20.51523658
107SMG10.51315849
108ROCK20.51267518
109CDK80.50503692
110PNCK0.49798909
111ERBB40.49038289
112MAPK130.46684669
113ADRBK10.46100030
114TRIM280.45109384
115AURKA0.44619008
116SIK30.44326975
117FGFR40.43848322
118RPS6KA60.42756545
119ERBB20.42347681
120MAPKAPK20.41405956
121ERBB30.41399812
122CDK60.40578938
123HIPK20.39733045
124NME20.38817596
125STK380.38640884
126MAP3K130.38464558
127CSNK1A10.37845352
128AKT20.37547247
129MUSK0.37541889
130PKN10.36402409
131MAP2K70.36002175
132PDGFRB0.35738743
133CAMKK20.35520231
134RPS6KB10.35231862
135PRKCE0.35137811
136NLK0.34792843
137PRKCG0.34762904
138TNK20.34524784
139PBK0.34145909
140PAK30.33820373
141DYRK1B0.33795699
142PKN20.33413348
143PTK2B0.33370136
144TBK10.32914283
145TESK10.31932025
146GSK3A0.31858465
147CASK0.31438331
148PAK40.31311770
149DAPK10.30967157
150SIK20.30342192
151PRKAA20.29929029
152ILK0.29785145
153NEK10.28799879
154TNIK0.26292188
155PDPK10.25767411
156RPS6KA10.25032178
157CAMK2G0.23946751
158PRKACA0.23409774

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.33413178
2Fat digestion and absorption_Homo sapiens_hsa049753.42601444
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.26378687
4Phototransduction_Homo sapiens_hsa047442.79567565
5Fatty acid elongation_Homo sapiens_hsa000622.60434760
6Sulfur relay system_Homo sapiens_hsa041222.45086815
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16386168
8Caffeine metabolism_Homo sapiens_hsa002322.12908244
9Mineral absorption_Homo sapiens_hsa049782.12736043
10Basal cell carcinoma_Homo sapiens_hsa052172.10406993
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99793136
12ECM-receptor interaction_Homo sapiens_hsa045121.95041486
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92875498
14Chemical carcinogenesis_Homo sapiens_hsa052041.89702277
15Tight junction_Homo sapiens_hsa045301.85930460
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.84089269
17Linoleic acid metabolism_Homo sapiens_hsa005911.83653387
18Protein digestion and absorption_Homo sapiens_hsa049741.82790720
19Fatty acid biosynthesis_Homo sapiens_hsa000611.81635058
20Hedgehog signaling pathway_Homo sapiens_hsa043401.73693528
21Nitrogen metabolism_Homo sapiens_hsa009101.69664714
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69498011
23Ether lipid metabolism_Homo sapiens_hsa005651.67329116
24Ovarian steroidogenesis_Homo sapiens_hsa049131.64248019
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60935724
26Butanoate metabolism_Homo sapiens_hsa006501.59967986
27Sphingolipid metabolism_Homo sapiens_hsa006001.59692553
28Tryptophan metabolism_Homo sapiens_hsa003801.57864239
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.57098095
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.56323720
31Steroid biosynthesis_Homo sapiens_hsa001001.51647348
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46764296
33ABC transporters_Homo sapiens_hsa020101.38619817
34Retinol metabolism_Homo sapiens_hsa008301.38294875
35Renin-angiotensin system_Homo sapiens_hsa046141.38208505
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38081040
37Axon guidance_Homo sapiens_hsa043601.36269241
38GnRH signaling pathway_Homo sapiens_hsa049121.33522034
39Taste transduction_Homo sapiens_hsa047421.33394677
40Salivary secretion_Homo sapiens_hsa049701.33267827
41Hippo signaling pathway_Homo sapiens_hsa043901.29615478
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.27454764
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.23796482
44Melanogenesis_Homo sapiens_hsa049161.23422303
45Fanconi anemia pathway_Homo sapiens_hsa034601.23013151
46Arginine and proline metabolism_Homo sapiens_hsa003301.21822767
47Selenocompound metabolism_Homo sapiens_hsa004501.18265169
48Histidine metabolism_Homo sapiens_hsa003401.17677713
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17407190
50Collecting duct acid secretion_Homo sapiens_hsa049661.16715076
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14600546
52VEGF signaling pathway_Homo sapiens_hsa043701.12986376
53beta-Alanine metabolism_Homo sapiens_hsa004101.12404868
54Oxidative phosphorylation_Homo sapiens_hsa001901.11061965
55Gastric acid secretion_Homo sapiens_hsa049711.10430270
56Homologous recombination_Homo sapiens_hsa034401.08956337
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07592929
58Adherens junction_Homo sapiens_hsa045201.07480519
59Proteoglycans in cancer_Homo sapiens_hsa052051.07469970
60Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05546804
61Renal cell carcinoma_Homo sapiens_hsa052111.04256843
62Amoebiasis_Homo sapiens_hsa051461.04185815
63Vitamin digestion and absorption_Homo sapiens_hsa049771.04138913
64Dilated cardiomyopathy_Homo sapiens_hsa054141.03003528
65RNA polymerase_Homo sapiens_hsa030201.02648476
66Arachidonic acid metabolism_Homo sapiens_hsa005901.01281922
67Galactose metabolism_Homo sapiens_hsa000520.99901115
68Focal adhesion_Homo sapiens_hsa045100.99630817
69Vibrio cholerae infection_Homo sapiens_hsa051100.99455418
70Starch and sucrose metabolism_Homo sapiens_hsa005000.95992158
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94130030
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89885588
73Peroxisome_Homo sapiens_hsa041460.85132694
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84738645
75Oxytocin signaling pathway_Homo sapiens_hsa049210.84419560
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.83872626
77Long-term depression_Homo sapiens_hsa047300.83407511
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.83198326
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83184051
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82556665
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82386833
82Renin secretion_Homo sapiens_hsa049240.81980168
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81734610
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.81733729
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76529996
86Propanoate metabolism_Homo sapiens_hsa006400.76167647
87Dorso-ventral axis formation_Homo sapiens_hsa043200.74359171
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74134728
89Pancreatic secretion_Homo sapiens_hsa049720.73767852
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.73694533
91Basal transcription factors_Homo sapiens_hsa030220.73089495
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71387083
93Metabolic pathways_Homo sapiens_hsa011000.71331413
94Bladder cancer_Homo sapiens_hsa052190.69718589
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69276862
96Long-term potentiation_Homo sapiens_hsa047200.68084768
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67239502
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.66537305
99Olfactory transduction_Homo sapiens_hsa047400.66326407
100Insulin resistance_Homo sapiens_hsa049310.65566749
101Fatty acid metabolism_Homo sapiens_hsa012120.64176552
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64088982
103Thyroid cancer_Homo sapiens_hsa052160.63552789
104Wnt signaling pathway_Homo sapiens_hsa043100.62534389
105Huntingtons disease_Homo sapiens_hsa050160.62240377
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.61198673
107Estrogen signaling pathway_Homo sapiens_hsa049150.61032846
108Arginine biosynthesis_Homo sapiens_hsa002200.60824883
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59998794
110Insulin signaling pathway_Homo sapiens_hsa049100.59982904
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.59094315
112Phenylalanine metabolism_Homo sapiens_hsa003600.58124161
113Ras signaling pathway_Homo sapiens_hsa040140.57941712
114Glioma_Homo sapiens_hsa052140.57296537
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.57207337
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57016670
117Glycerolipid metabolism_Homo sapiens_hsa005610.56760063
118ErbB signaling pathway_Homo sapiens_hsa040120.55805793
119Cardiac muscle contraction_Homo sapiens_hsa042600.55684496
120Sulfur metabolism_Homo sapiens_hsa009200.55601552
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55467650
122Bile secretion_Homo sapiens_hsa049760.54949986
123Notch signaling pathway_Homo sapiens_hsa043300.54286457
124Endometrial cancer_Homo sapiens_hsa052130.53814728
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53683879
126PPAR signaling pathway_Homo sapiens_hsa033200.52789110
127Parkinsons disease_Homo sapiens_hsa050120.52700130
128Alzheimers disease_Homo sapiens_hsa050100.52598564
129TGF-beta signaling pathway_Homo sapiens_hsa043500.52561789
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52423067
131Prolactin signaling pathway_Homo sapiens_hsa049170.51931952
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51677882
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51235785
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.51004281
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50668574
136Glutathione metabolism_Homo sapiens_hsa004800.50457771
137AMPK signaling pathway_Homo sapiens_hsa041520.50194404
138Regulation of autophagy_Homo sapiens_hsa041400.50151665
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48147913
140Pyruvate metabolism_Homo sapiens_hsa006200.47957389
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47393011
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46377839
143Gap junction_Homo sapiens_hsa045400.46144941
144Toxoplasmosis_Homo sapiens_hsa051450.44806709
145One carbon pool by folate_Homo sapiens_hsa006700.44426218
146Synaptic vesicle cycle_Homo sapiens_hsa047210.44013972
147cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43706307
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42907138
149Fructose and mannose metabolism_Homo sapiens_hsa000510.42853213
150Tyrosine metabolism_Homo sapiens_hsa003500.39341827
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36976667
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36651372
153Insulin secretion_Homo sapiens_hsa049110.34321087
154Purine metabolism_Homo sapiens_hsa002300.34222107
155Fatty acid degradation_Homo sapiens_hsa000710.33134316
156Base excision repair_Homo sapiens_hsa034100.29040707
157Pyrimidine metabolism_Homo sapiens_hsa002400.28270179
158Nicotine addiction_Homo sapiens_hsa050330.24097427
159Protein export_Homo sapiens_hsa030600.23823857
160RNA degradation_Homo sapiens_hsa030180.23038697
161Serotonergic synapse_Homo sapiens_hsa047260.22578001

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