BASP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phosphate ion transport (GO:0006817)8.84592968
2response to histamine (GO:0034776)8.68387246
3galactose catabolic process (GO:0019388)7.01468346
4cerebellar granule cell differentiation (GO:0021707)6.82413922
5cochlea development (GO:0090102)6.51315823
6galactose metabolic process (GO:0006012)6.10687945
7positive regulation of glomerulus development (GO:0090193)5.97265582
8inner ear receptor cell development (GO:0060119)5.91191978
9pattern specification involved in kidney development (GO:0061004)5.40493976
10negative regulation of metanephros development (GO:0072217)5.22049597
11lens fiber cell development (GO:0070307)5.18860127
12positive regulation of interferon-gamma biosynthetic process (GO:0045078)5.18023250
13cellular response to ammonium ion (GO:0071242)5.14414276
14metanephric nephron epithelium development (GO:0072243)5.02349857
15metanephric epithelium development (GO:0072207)4.99462739
16mesenchymal cell differentiation involved in kidney development (GO:0072161)4.91729756
17mesenchymal cell differentiation involved in renal system development (GO:2001012)4.91729756
18regulation of glomerulus development (GO:0090192)4.90289564
19regulation of apoptotic process involved in morphogenesis (GO:1902337)4.85007879
20regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.82796870
21ncRNA 3-end processing (GO:0043628)4.81518695
22negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.76255011
23regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.67422003
24cell differentiation involved in metanephros development (GO:0072202)4.65174468
25regulation of germinal center formation (GO:0002634)4.56463250
26positive regulation of metanephros development (GO:0072216)4.55654350
27mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.52665120
28nephron tubule formation (GO:0072079)4.44877065
29innervation (GO:0060384)4.43539682
30regulation of stem cell maintenance (GO:2000036)4.42215710
31flavonoid metabolic process (GO:0009812)4.34318084
32urogenital system development (GO:0001655)4.24677842
33gamma-aminobutyric acid signaling pathway (GO:0007214)4.24129020
34positive regulation by host of viral transcription (GO:0043923)4.20995874
35adrenergic receptor signaling pathway (GO:0071875)4.20700255
36negative regulation of systemic arterial blood pressure (GO:0003085)4.11667742
37regulation of mesenchymal cell apoptotic process (GO:2001053)4.08948630
38mesonephros development (GO:0001823)4.08692169
39adaptation of signaling pathway (GO:0023058)4.04030334
40metanephric mesenchyme development (GO:0072075)4.00393367
41cell proliferation in forebrain (GO:0021846)3.90009954
42regulation of interferon-gamma biosynthetic process (GO:0045072)3.89997411
43sex differentiation (GO:0007548)3.76063467
44regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.71821318
45metanephric tubule development (GO:0072170)3.68212557
46metanephric nephron tubule development (GO:0072234)3.68212557
47ribosomal small subunit biogenesis (GO:0042274)3.64658772
48peptide cross-linking (GO:0018149)3.54954404
49kidney mesenchyme development (GO:0072074)3.53297036
50regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.53141796
51DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.51239170
52nuclear pore complex assembly (GO:0051292)3.49949218
53regulation of digestive system process (GO:0044058)3.47797623
54asymmetric protein localization (GO:0008105)3.43537454
55negative regulation by host of viral transcription (GO:0043922)3.42672948
56negative regulation of glycogen metabolic process (GO:0070874)3.40987785
57cellular response to exogenous dsRNA (GO:0071360)3.38599200
58negative regulation of kidney development (GO:0090185)3.35462268
59regulation of respiratory system process (GO:0044065)3.32872413
60NAD biosynthetic process (GO:0009435)3.32108090
61cranial nerve morphogenesis (GO:0021602)3.31966439
62inorganic anion transmembrane transport (GO:0098661)3.24732874
63cellular response to virus (GO:0098586)3.22822160
64negative regulation of smooth muscle cell differentiation (GO:0051151)3.17456150
65regulation of transcription involved in cell fate commitment (GO:0060850)3.15063435
66DNA damage response, signal transduction resulting in transcription (GO:0042772)3.13244912
67cytoplasmic mRNA processing body assembly (GO:0033962)3.12357474
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10752683
69regulation of cell proliferation involved in kidney development (GO:1901722)3.09946468
70regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.06522870
71cell differentiation in hindbrain (GO:0021533)3.02028330
72mesenchymal to epithelial transition (GO:0060231)3.01532763
73nephron epithelium development (GO:0072009)2.99680495
74cellular response to nicotine (GO:0071316)2.99556915
75pore complex assembly (GO:0046931)2.95078841
76regulation of interferon-beta biosynthetic process (GO:0045357)2.90578069
77cell proliferation involved in metanephros development (GO:0072203)2.89552083
78regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.89332790
79embryonic foregut morphogenesis (GO:0048617)2.88727506
80insulin-like growth factor receptor signaling pathway (GO:0048009)2.87325294
81type B pancreatic cell proliferation (GO:0044342)2.84314094
82regulation of metanephros development (GO:0072215)2.84003432
83somatic stem cell division (GO:0048103)2.81721695
84peptidyl-proline hydroxylation (GO:0019511)2.81092135
85middle ear morphogenesis (GO:0042474)2.79558011
86response to water (GO:0009415)2.78545845
87regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.78512653
88nucleotide transmembrane transport (GO:1901679)2.78241325
89lymph vessel development (GO:0001945)2.77168978
90inorganic anion transport (GO:0015698)2.74440487
91renal tubule development (GO:0061326)2.70981094
92negative regulation of multicellular organism growth (GO:0040015)2.67667693
93nicotinamide nucleotide biosynthetic process (GO:0019359)2.67455546
94pyridine nucleotide biosynthetic process (GO:0019363)2.67455546
95protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)2.66802702
96cellular glucuronidation (GO:0052695)2.65127057
97nephron tubule development (GO:0072080)2.65022075
98tachykinin receptor signaling pathway (GO:0007217)13.7293201
99positive regulation of digestive system process (GO:0060456)10.5378923
100phosphate ion transmembrane transport (GO:0035435)10.5147822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98242728
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.99083502
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73241588
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.65028895
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.31957843
6EED_16625203_ChIP-ChIP_MESCs_Mouse3.18522336
7CDX2_20551321_ChIP-Seq_CACO-2_Human3.04266636
8ZNF274_21170338_ChIP-Seq_K562_Hela2.60857201
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49403430
10RNF2_27304074_Chip-Seq_NSC_Mouse2.32667315
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31579769
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31579769
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.26942081
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25620876
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12104048
16DNAJC2_21179169_ChIP-ChIP_NT2_Human2.07437351
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.06016887
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04454045
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.01791628
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00610887
21TP53_20018659_ChIP-ChIP_R1E_Mouse1.96977072
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91255341
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90141631
24SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89207622
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85007214
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84287987
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83816102
28EGR1_19032775_ChIP-ChIP_M12_Human1.82063635
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79231725
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79055633
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.76075403
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.70396778
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.68420999
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66515195
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66423139
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65786441
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65246138
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.49830972
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.49588675
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43540917
41GBX2_23144817_ChIP-Seq_PC3_Human1.41878993
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.40215028
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36576851
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31972459
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31811023
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30085181
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28247937
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27665118
49ZNF263_19887448_ChIP-Seq_K562_Human1.26889372
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.20548813
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14721407
52NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.14031344
53RAC3_21632823_ChIP-Seq_H3396_Human1.12199723
54CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11936538
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.10338135
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09673980
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07202341
58CTCF_27219007_Chip-Seq_Bcells_Human1.04501166
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03501895
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03464717
61REST_21632747_ChIP-Seq_MESCs_Mouse1.03130241
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.02688205
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.02454291
64ESR2_21235772_ChIP-Seq_MCF-7_Human0.98979903
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98774245
66ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95920681
67CTCF_26484167_Chip-Seq_Bcells_Mouse0.95024469
68SMAD4_21741376_ChIP-Seq_HESCs_Human0.94711759
69TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.93956402
70GF1_26923725_Chip-Seq_HPCs_Mouse0.93787344
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92338340
72SA1_27219007_Chip-Seq_Bcells_Human0.91602903
73TET1_21451524_ChIP-Seq_MESCs_Mouse0.91597617
74JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.91260621
75ERA_21632823_ChIP-Seq_H3396_Human0.91257011
76VDR_24787735_ChIP-Seq_THP-1_Human0.90266921
77DROSHA_22980978_ChIP-Seq_HELA_Human0.90222296
78TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89745508
79RACK7_27058665_Chip-Seq_MCF-7_Human0.88029088
80SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87734573
81PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87418205
82TCF3_18692474_ChIP-Seq_MESCs_Mouse0.85898681
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85112729
84KDM2B_26808549_Chip-Seq_K562_Human0.83490565
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83298027
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82673688
87TDRD3_21172665_ChIP-Seq_MCF-7_Human0.82228575
88AR_21572438_ChIP-Seq_LNCaP_Human0.81283539
89ISL1_27105846_Chip-Seq_CPCs_Mouse0.80888389
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.80708301
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.79382377
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78885852
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.78323771
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.77740289
95SMC3_22415368_ChIP-Seq_MEFs_Mouse0.77258654
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77048513
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76690779
98KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.76422278
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.76384985
100WT1_25993318_ChIP-Seq_PODOCYTE_Human0.74061532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder5.32295810
2MP0003195_calcinosis5.08254105
3MP0008260_abnormal_autophagy4.70867549
4MP0000372_irregular_coat_pigmentation4.59414647
5MP0009780_abnormal_chondrocyte_physiolo4.19743970
6MP0000534_abnormal_ureter_morphology3.52588123
7MP0009250_abnormal_appendicular_skeleto2.99640835
8MP0004510_myositis2.87939272
9MP0002009_preneoplasia2.65258217
10MP0001501_abnormal_sleep_pattern2.64710566
11MP0006276_abnormal_autonomic_nervous2.50980044
12MP0005377_hearing/vestibular/ear_phenot2.09129516
13MP0003878_abnormal_ear_physiology2.09129516
14MP0005023_abnormal_wound_healing2.06435270
15MP0005084_abnormal_gallbladder_morpholo2.01702601
16MP0001502_abnormal_circadian_rhythm1.98827347
17MP0004272_abnormal_basement_membrane1.85105218
18MP0005645_abnormal_hypothalamus_physiol1.79402402
19MP0002933_joint_inflammation1.76182064
20MP0002653_abnormal_ependyma_morphology1.73665292
21MP0005451_abnormal_body_composition1.73515115
22MP0003938_abnormal_ear_development1.68825929
23MP0000049_abnormal_middle_ear1.66213363
24MP0003283_abnormal_digestive_organ1.59281774
25MP0000538_abnormal_urinary_bladder1.58985962
26MP0002736_abnormal_nociception_after1.58892916
27MP0001324_abnormal_eye_pigmentation1.47095100
28MP0002184_abnormal_innervation1.45694694
29MP0003942_abnormal_urinary_system1.44343438
30MP0000778_abnormal_nervous_system1.42114682
31MP0002735_abnormal_chemical_nociception1.41899655
32MP0001873_stomach_inflammation1.29579516
33MP0000026_abnormal_inner_ear1.28971657
34MP0003879_abnormal_hair_cell1.28390616
35MP0001440_abnormal_grooming_behavior1.27855574
36MP0003646_muscle_fatigue1.27241390
37MP0008872_abnormal_physiological_respon1.25100770
38MP0002928_abnormal_bile_duct1.24260146
39MP0001299_abnormal_eye_distance/1.21718244
40MP0001968_abnormal_touch/_nociception1.19596235
41MP0003936_abnormal_reproductive_system1.17097103
42MP0004019_abnormal_vitamin_homeostasis1.16176137
43MP0005551_abnormal_eye_electrophysiolog1.15684568
44MP0001879_abnormal_lymphatic_vessel1.14206314
45MP0008438_abnormal_cutaneous_collagen1.14129668
46MP0002557_abnormal_social/conspecific_i1.14006534
47MP0002751_abnormal_autonomic_nervous1.11764648
48MP0001905_abnormal_dopamine_level1.11462035
49MP0003943_abnormal_hepatobiliary_system1.10255431
50MP0002115_abnormal_skeleton_extremities1.08513656
51MP0004885_abnormal_endolymph1.06019168
52MP0003303_peritoneal_inflammation1.05880306
53MP0000566_synostosis1.05423793
54MP0008995_early_reproductive_senescence1.03472571
55MP0003633_abnormal_nervous_system1.02610622
56MP0009745_abnormal_behavioral_response1.01461755
57MP0005165_increased_susceptibility_to0.98821161
58MP0000762_abnormal_tongue_morphology0.98684030
59MP0000537_abnormal_urethra_morphology0.98058121
60MP0001963_abnormal_hearing_physiology0.97678315
61MP0003172_abnormal_lysosome_physiology0.96663046
62MP0003635_abnormal_synaptic_transmissio0.96159228
63MP0000163_abnormal_cartilage_morphology0.94075045
64MP0004133_heterotaxia0.93801071
65MP0002572_abnormal_emotion/affect_behav0.92795356
66MP0001270_distended_abdomen0.92584443
67MP0005167_abnormal_blood-brain_barrier0.92389514
68MP0001664_abnormal_digestion0.88786629
69MP0002067_abnormal_sensory_capabilities0.88651455
70MP0005197_abnormal_uvea_morphology0.86964300
71MP0005647_abnormal_sex_gland0.86010998
72MP0003937_abnormal_limbs/digits/tail_de0.85551755
73MP0001119_abnormal_female_reproductive0.80771886
74MP0004484_altered_response_of0.79884740
75MP0002135_abnormal_kidney_morphology0.77240862
76MP0003191_abnormal_cellular_cholesterol0.76848942
77MP0002733_abnormal_thermal_nociception0.75936183
78MP0002998_abnormal_bone_remodeling0.75826326
79MP0004134_abnormal_chest_morphology0.74614423
80MP0004043_abnormal_pH_regulation0.74547930
81MP0002909_abnormal_adrenal_gland0.73262098
82MP0005671_abnormal_response_to0.71905167
83MP0002116_abnormal_craniofacial_bone0.71633352
84MP0001764_abnormal_homeostasis0.70761879
85MP0002693_abnormal_pancreas_physiology0.69584365
86MP0001663_abnormal_digestive_system0.69579045
87MP0002089_abnormal_postnatal_growth/wei0.68363033
88MP0002419_abnormal_innate_immunity0.68259932
89MP0002109_abnormal_limb_morphology0.68209932
90MP0003566_abnormal_cell_adhesion0.68200696
91MP0005508_abnormal_skeleton_morphology0.68153682
92MP0006138_congestive_heart_failure0.68136722
93MP0004858_abnormal_nervous_system0.67202306
94MP0002168_other_aberrant_phenotype0.66991075
95MP0002177_abnormal_outer_ear0.66095763
96MP0010234_abnormal_vibrissa_follicle0.65785143
97MP0004185_abnormal_adipocyte_glucose0.64280859
98MP0001944_abnormal_pancreas_morphology0.63885775
99MP0002113_abnormal_skeleton_development0.63651042
100MP0002132_abnormal_respiratory_system0.63261218

Predicted human phenotypes

RankGene SetZ-score
1Fibular aplasia (HP:0002990)9.55684212
2Aplasia/Hypoplasia of the pubic bone (HP:0009104)7.36709689
3Aplasia/Hypoplasia involving the carpal bones (HP:0006502)6.99263810
4Abnormality of the pubic bones (HP:0003172)5.60546827
5Split foot (HP:0001839)5.03724042
6Humeroradial synostosis (HP:0003041)4.94387299
7Synostosis involving the elbow (HP:0003938)4.94387299
8Hypoplastic pelvis (HP:0008839)4.89702554
9Oligodactyly (hands) (HP:0001180)4.78480725
10Abnormal finger flexion creases (HP:0006143)4.29757455
11Abnormality of macular pigmentation (HP:0008002)4.05163499
12Hypoplastic iliac wings (HP:0002866)4.03832897
13Aplasia/hypoplasia of the uterus (HP:0008684)3.90810848
14Aplasia/Hypoplasia of the fibula (HP:0006492)3.69537631
15Broad ribs (HP:0000885)3.61784349
16Barrel-shaped chest (HP:0001552)3.61369423
17Recurrent pneumonia (HP:0006532)3.57339609
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.48838253
19Oligodactyly (HP:0012165)3.45995834
20Birth length less than 3rd percentile (HP:0003561)3.45762019
21Radial bowing (HP:0002986)3.34685204
22Decreased central vision (HP:0007663)3.34683414
23Neoplasm of the heart (HP:0100544)3.24429479
24Athetosis (HP:0002305)3.12392583
25Adactyly (HP:0009776)3.08957129
26Carpal bone hypoplasia (HP:0001498)3.07904157
27Patellar aplasia (HP:0006443)3.05650343
28Shawl scrotum (HP:0000049)3.04673202
29Premature rupture of membranes (HP:0001788)2.98746178
30Absent forearm bone (HP:0003953)2.95082773
31Aplasia involving forearm bones (HP:0009822)2.95082773
32Focal segmental glomerulosclerosis (HP:0000097)2.94267517
33Aplasia/Hypoplasia of the patella (HP:0006498)2.89908934
34Gastrointestinal stroma tumor (HP:0100723)2.80280145
35Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.78034617
36Lymphangioma (HP:0100764)2.74895211
37Breast hypoplasia (HP:0003187)2.72619752
38Hypoplastic ischia (HP:0003175)2.72511111
39Abnormality of cochlea (HP:0000375)2.71442666
40Achilles tendon contracture (HP:0001771)2.70427745
41Ependymoma (HP:0002888)2.69697293
42Disproportionate short-trunk short stature (HP:0003521)2.63013693
43Symphalangism affecting the phalanges of the hand (HP:0009773)2.61880182
44Abnormality of the Achilles tendon (HP:0005109)2.58002057
45Hemivertebrae (HP:0002937)2.56038387
46Macular degeneration (HP:0000608)2.55920890
47Premature graying of hair (HP:0002216)2.54735184
48Soft skin (HP:0000977)2.54374068
49Beaking of vertebral bodies (HP:0004568)2.53841703
50Recurrent sinusitis (HP:0011108)2.52731803
51Breech presentation (HP:0001623)2.51970775
52Hypoplastic ilia (HP:0000946)2.51483136
53Abnormality of the wing of the ilium (HP:0011867)2.47455314
54Recurrent lower respiratory tract infections (HP:0002783)2.46866517
55Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.45544059
56Bowing of the arm (HP:0006488)2.41048385
57Bowed forearm bones (HP:0003956)2.41048385
58Emphysema (HP:0002097)2.38613073
59Abnormality of the ischium (HP:0003174)2.36836797
60Hemorrhage of the eye (HP:0011885)2.34563618
61Skull defect (HP:0001362)2.34245157
62Hypoplasia of the odontoid process (HP:0003311)2.32419604
63Wrist flexion contracture (HP:0001239)2.30414361
64Striae distensae (HP:0001065)2.28470543
65Autoamputation (HP:0001218)2.25648376
66Poikiloderma (HP:0001029)2.25030482
67Hypoplastic nipples (HP:0002557)2.24317754
68Visceral angiomatosis (HP:0100761)2.22109273
69Abnormality of the odontoid process (HP:0003310)2.21582181
70Genu varum (HP:0002970)2.20421108
71Microglossia (HP:0000171)2.16048404
72Increased hepatocellular lipid droplets (HP:0006565)2.13620210
73Hemangiomatosis (HP:0007461)2.12439730
74Mesomelia (HP:0003027)2.12292525
75Morphological abnormality of the inner ear (HP:0011390)2.11779160
76Potter facies (HP:0002009)2.11626605
77Facial shape deformation (HP:0011334)2.11626605
78Femoral bowing (HP:0002980)2.09291467
79Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.08178012
80Glomerulosclerosis (HP:0000096)2.07744139
81Hypophosphatemic rickets (HP:0004912)2.07004317
82Abnormality of the fibula (HP:0002991)2.06381640
83Cerebral hemorrhage (HP:0001342)2.02076357
84Rough bone trabeculation (HP:0100670)1.99853091
85Restrictive lung disease (HP:0002091)1.99744110
86Long clavicles (HP:0000890)1.98992391
87Vaginal atresia (HP:0000148)1.98207605
88Aplasia/Hypoplasia of the scapulae (HP:0006713)1.97733059
89Hypoplastic scapulae (HP:0000882)1.97733059
90Bicornuate uterus (HP:0000813)1.92516840
91Abnormality of the humeroradial joint (HP:0100744)1.91935843
92Prolonged neonatal jaundice (HP:0006579)1.88558552
93Abnormality of the humerus (HP:0003063)1.86613788
94Genital tract atresia (HP:0001827)1.84924493
95Neuroendocrine neoplasm (HP:0100634)1.84806949
96Abnormality of the upper arm (HP:0001454)1.83836850
97Abnormality of the astrocytes (HP:0100707)1.83761127
98Astrocytoma (HP:0009592)1.83761127
99Attenuation of retinal blood vessels (HP:0007843)1.82990465
100Hypoplastic left heart (HP:0004383)1.81311651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.81185918
2NEK64.58069153
3NTRK13.98453437
4MATK3.21110663
5ERBB22.91442750
6EPHA22.70286309
7PKN12.60112239
8EPHA32.32109796
9PDK22.16096699
10CASK2.03669683
11MAP2K61.99638373
12RPS6KA21.99538580
13PRPF4B1.93572949
14MAP2K71.91887590
15MAP3K41.88723930
16ILK1.84199507
17BLK1.80888252
18MYLK1.64320695
19RPS6KA61.63298858
20DAPK31.61873668
21KIT1.55929908
22RPS6KC11.52076945
23RPS6KL11.52076945
24CSNK1A1L1.50746388
25WNK11.49853031
26PRKD31.48075427
27ADRBK21.45134133
28MAP3K101.38509635
29CDK121.36659453
30FRK1.25913828
31MAPKAPK31.19763690
32MELK1.18761130
33PRKCE1.15527721
34ERN11.14962211
35TAOK21.12835574
36MST1R1.09935928
37ALK1.08719845
38EPHB21.07326186
39ROCK21.02538401
40CAMK2G1.01692361
41PRKD21.00611088
42TAOK10.97671695
43DDR20.97386041
44MAP2K40.97095526
45GSK3A0.89096683
46ADRBK10.88177215
47CAMK2B0.87871671
48CCNB10.85396777
49MAPKAPK20.79309112
50RPS6KA10.79299285
51SRPK10.76131233
52PRKCZ0.74501629
53PRKD10.73172574
54FGFR10.72449200
55EIF2AK10.71973434
56TGFBR20.71895493
57WNK40.71791943
58STK240.70429820
59TBK10.67333616
60EPHB10.63476367
61MET0.60902183
62NUAK10.60132496
63INSR0.58864114
64HIPK20.56465316
65FGFR40.55085124
66TIE10.54583658
67MAPK90.54432048
68PIM20.53257326
69CDK80.51627456
70SGK4940.50887006
71SGK2230.50887006
72ARAF0.49930952
73RPS6KA30.49577979
74FGFR30.48162143
75PRKCA0.47133115
76CAMK2A0.46662950
77FLT30.45976388
78PRKCD0.44655709
79MARK10.44429979
80DYRK30.43686080
81CAMK2D0.43179989
82CDC42BPA0.42693414
83CSNK1G20.42615546
84PASK0.42267710
85IKBKB0.41217874
86CHUK0.41160546
87RPS6KA50.40117455
88SYK0.39363747
89CSNK1A10.38027157
90STK30.37647988
91NLK0.37315928
92PRKACG0.36914435
93IGF1R0.34156887
94DMPK0.33989865
95MAPK80.32239740
96PRKCH0.32057268
97ACVR1B0.28351846
98MAPK40.27765027
99ATM0.27004043
100TLK10.26241722

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.93241731
2Galactose metabolism_Homo sapiens_hsa000523.31959978
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.75362888
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67521823
5Morphine addiction_Homo sapiens_hsa050322.65243809
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44001019
7Steroid hormone biosynthesis_Homo sapiens_hsa001402.24718218
8Hedgehog signaling pathway_Homo sapiens_hsa043402.23047532
9Thyroid hormone synthesis_Homo sapiens_hsa049182.16702154
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.14421113
11Primary immunodeficiency_Homo sapiens_hsa053401.93143305
12GABAergic synapse_Homo sapiens_hsa047271.86655030
13Glycerolipid metabolism_Homo sapiens_hsa005611.85080369
14Basal cell carcinoma_Homo sapiens_hsa052171.65319965
15Starch and sucrose metabolism_Homo sapiens_hsa005001.65137336
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62932151
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.60849600
18Caffeine metabolism_Homo sapiens_hsa002321.59668980
19Serotonergic synapse_Homo sapiens_hsa047261.54108795
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.50378673
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45585377
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.40280074
23Phenylalanine metabolism_Homo sapiens_hsa003601.25500496
24Phototransduction_Homo sapiens_hsa047441.21793815
25Ovarian steroidogenesis_Homo sapiens_hsa049131.20996104
26Choline metabolism in cancer_Homo sapiens_hsa052311.18483651
27Asthma_Homo sapiens_hsa053101.13729271
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06165208
29Vitamin B6 metabolism_Homo sapiens_hsa007501.05254236
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.04862265
31Basal transcription factors_Homo sapiens_hsa030221.02956259
32Maturity onset diabetes of the young_Homo sapiens_hsa049500.99102302
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97422769
34Folate biosynthesis_Homo sapiens_hsa007900.97272981
35ABC transporters_Homo sapiens_hsa020100.96341328
36Renin-angiotensin system_Homo sapiens_hsa046140.96274044
37Wnt signaling pathway_Homo sapiens_hsa043100.93188094
38Renin secretion_Homo sapiens_hsa049240.93013760
39Gastric acid secretion_Homo sapiens_hsa049710.92977402
40Sphingolipid metabolism_Homo sapiens_hsa006000.92952637
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92488959
42Calcium signaling pathway_Homo sapiens_hsa040200.90866576
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.90302758
44Retinol metabolism_Homo sapiens_hsa008300.88650758
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87628484
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83940539
47Melanogenesis_Homo sapiens_hsa049160.83419137
48Renal cell carcinoma_Homo sapiens_hsa052110.82742796
49Dopaminergic synapse_Homo sapiens_hsa047280.82578517
50mTOR signaling pathway_Homo sapiens_hsa041500.81178836
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80189081
52VEGF signaling pathway_Homo sapiens_hsa043700.78986500
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78324542
54Arachidonic acid metabolism_Homo sapiens_hsa005900.77241013
55Type II diabetes mellitus_Homo sapiens_hsa049300.76082434
56Salivary secretion_Homo sapiens_hsa049700.75998705
57Taste transduction_Homo sapiens_hsa047420.74589706
58Histidine metabolism_Homo sapiens_hsa003400.72338490
59Cocaine addiction_Homo sapiens_hsa050300.71824256
60Circadian entrainment_Homo sapiens_hsa047130.64644188
61Olfactory transduction_Homo sapiens_hsa047400.63509048
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63123526
63Hepatitis C_Homo sapiens_hsa051600.61603232
64FoxO signaling pathway_Homo sapiens_hsa040680.59572293
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58730853
66AMPK signaling pathway_Homo sapiens_hsa041520.58070402
67African trypanosomiasis_Homo sapiens_hsa051430.56671029
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.54466806
69RNA degradation_Homo sapiens_hsa030180.53468424
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53277531
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51467174
72Amphetamine addiction_Homo sapiens_hsa050310.51242869
73Influenza A_Homo sapiens_hsa051640.50739081
74Tryptophan metabolism_Homo sapiens_hsa003800.50545403
75Hippo signaling pathway_Homo sapiens_hsa043900.50432746
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47055200
77Protein digestion and absorption_Homo sapiens_hsa049740.46993705
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46034884
79Prolactin signaling pathway_Homo sapiens_hsa049170.45347671
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44905835
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44203724
82HIF-1 signaling pathway_Homo sapiens_hsa040660.43840865
83HTLV-I infection_Homo sapiens_hsa051660.43710440
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42745273
85Leishmaniasis_Homo sapiens_hsa051400.42226644
86Chemical carcinogenesis_Homo sapiens_hsa052040.41558971
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39950562
88Glutathione metabolism_Homo sapiens_hsa004800.39649376
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39432162
90Glutamatergic synapse_Homo sapiens_hsa047240.38645675
91Cholinergic synapse_Homo sapiens_hsa047250.38434258
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.38088147
93Staphylococcus aureus infection_Homo sapiens_hsa051500.36696498
94Collecting duct acid secretion_Homo sapiens_hsa049660.36693918
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35105820
96TNF signaling pathway_Homo sapiens_hsa046680.34027705
97MAPK signaling pathway_Homo sapiens_hsa040100.32703429
98ECM-receptor interaction_Homo sapiens_hsa045120.32688837
99Synaptic vesicle cycle_Homo sapiens_hsa047210.32296507
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.31800496

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