

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.80169313 |
| 2 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.18721144 |
| 3 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.18721144 |
| 4 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.15314974 |
| 5 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.78796175 |
| 6 | regulation of T-helper 1 cell differentiation (GO:0045625) | 4.56203071 |
| 7 | ribosomal small subunit assembly (GO:0000028) | 4.51102904 |
| 8 | leukocyte aggregation (GO:0070486) | 3.95339776 |
| 9 | type I interferon signaling pathway (GO:0060337) | 3.92116310 |
| 10 | cellular response to type I interferon (GO:0071357) | 3.92116310 |
| 11 | response to type I interferon (GO:0034340) | 3.89214472 |
| 12 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.87769462 |
| 13 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 3.81117788 |
| 14 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.80850019 |
| 15 | immunoglobulin mediated immune response (GO:0016064) | 3.77154286 |
| 16 | T cell migration (GO:0072678) | 3.77126130 |
| 17 | response to interferon-beta (GO:0035456) | 3.74015994 |
| 18 | * defense response to protozoan (GO:0042832) | 3.71214889 |
| 19 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.67319195 |
| 20 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.66041929 |
| 21 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.62640805 |
| 22 | regulation of gamma-delta T cell activation (GO:0046643) | 3.61839339 |
| 23 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.60858689 |
| 24 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.60294187 |
| 25 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.55723103 |
| 26 | neutrophil activation involved in immune response (GO:0002283) | 3.49506734 |
| 27 | * response to protozoan (GO:0001562) | 3.48066949 |
| 28 | mast cell activation (GO:0045576) | 3.45085789 |
| 29 | positive regulation of B cell differentiation (GO:0045579) | 3.44641003 |
| 30 | germinal center formation (GO:0002467) | 3.43508441 |
| 31 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.42686812 |
| 32 | macrophage activation involved in immune response (GO:0002281) | 3.42649213 |
| 33 | regulation of cytokine secretion involved in immune response (GO:0002739) | 3.37684234 |
| 34 | response to interleukin-15 (GO:0070672) | 3.37375276 |
| 35 | negative T cell selection (GO:0043383) | 3.36068717 |
| 36 | negative thymic T cell selection (GO:0045060) | 3.35177450 |
| 37 | cellular response to interferon-beta (GO:0035458) | 3.34577533 |
| 38 | regulation of T cell tolerance induction (GO:0002664) | 3.33047284 |
| 39 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.30741279 |
| 40 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.30741279 |
| 41 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.29248469 |
| 42 | NIK/NF-kappaB signaling (GO:0038061) | 3.27974566 |
| 43 | regulation of immunoglobulin secretion (GO:0051023) | 3.27531254 |
| 44 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.26671890 |
| 45 | regulation of interleukin-12 production (GO:0032655) | 3.24536732 |
| 46 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.24197227 |
| 47 | B cell mediated immunity (GO:0019724) | 3.23834069 |
| 48 | regulation of B cell differentiation (GO:0045577) | 3.23388180 |
| 49 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.22055816 |
| 50 | mature B cell differentiation (GO:0002335) | 3.21038613 |
| 51 | regulation of antigen processing and presentation (GO:0002577) | 3.20241843 |
| 52 | response to interferon-alpha (GO:0035455) | 3.17275416 |
| 53 | * myeloid dendritic cell activation (GO:0001773) | 3.17152394 |
| 54 | DNA deamination (GO:0045006) | 3.16748544 |
| 55 | cellular response to interferon-gamma (GO:0071346) | 3.15026348 |
| 56 | positive regulation of antigen processing and presentation (GO:0002579) | 3.14608996 |
| 57 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.14393543 |
| 58 | negative regulation of T cell mediated immunity (GO:0002710) | 3.12373935 |
| 59 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.12202434 |
| 60 | cellular response to interleukin-15 (GO:0071350) | 3.11707322 |
| 61 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.09989903 |
| 62 | interferon-gamma production (GO:0032609) | 3.09745615 |
| 63 | response to peptidoglycan (GO:0032494) | 3.06813972 |
| 64 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.06806677 |
| 65 | viral transcription (GO:0019083) | 3.06332959 |
| 66 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.06171169 |
| 67 | mature B cell differentiation involved in immune response (GO:0002313) | 3.06103822 |
| 68 | regulation of vitamin metabolic process (GO:0030656) | 3.04250050 |
| 69 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.02315230 |
| 70 | positive regulation of isotype switching (GO:0045830) | 3.00217656 |
| 71 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 2.98762864 |
| 72 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 2.94427541 |
| 73 | positive regulation of immunoglobulin mediated immune response (GO:0002891) | 2.94366674 |
| 74 | positive regulation of B cell mediated immunity (GO:0002714) | 2.94366674 |
| 75 | respiratory burst (GO:0045730) | 2.93333122 |
| 76 | translational termination (GO:0006415) | 2.93262189 |
| 77 | negative regulation of interleukin-12 production (GO:0032695) | 2.93222656 |
| 78 | tumor necrosis factor-mediated signaling pathway (GO:0033209) | 2.93042005 |
| 79 | negative regulation of viral genome replication (GO:0045071) | 2.92508113 |
| 80 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.92468151 |
| 81 | regulation of interferon-alpha production (GO:0032647) | 2.91955724 |
| 82 | regulation of podosome assembly (GO:0071801) | 2.90728463 |
| 83 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.90465835 |
| 84 | * myeloid dendritic cell differentiation (GO:0043011) | 2.89904832 |
| 85 | response to interferon-gamma (GO:0034341) | 2.89533256 |
| 86 | regulation of T-helper cell differentiation (GO:0045622) | 2.89401590 |
| 87 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.88078497 |
| 88 | positive regulation of interferon-alpha production (GO:0032727) | 2.87811404 |
| 89 | tolerance induction (GO:0002507) | 2.87102336 |
| 90 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 2.86896005 |
| 91 | B cell receptor signaling pathway (GO:0050853) | 2.86449130 |
| 92 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.86058373 |
| 93 | granulocyte activation (GO:0036230) | 2.85654362 |
| 94 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 2.85647711 |
| 95 | cellular response to zinc ion (GO:0071294) | 2.85581668 |
| 96 | regulation of response to interferon-gamma (GO:0060330) | 2.84827636 |
| 97 | regulation of T cell mediated cytotoxicity (GO:0001914) | 2.84822129 |
| 98 | regulation of chemokine biosynthetic process (GO:0045073) | 2.84636044 |
| 99 | positive regulation by symbiont of host defense response (GO:0052509) | 2.83604752 |
| 100 | modulation by symbiont of host defense response (GO:0052031) | 2.83604752 |
| 101 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 2.83604752 |
| 102 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 2.83604752 |
| 103 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 2.83604752 |
| 104 | modulation by symbiont of host immune response (GO:0052553) | 2.83604752 |
| 105 | positive regulation of interleukin-2 production (GO:0032743) | 2.83016145 |
| 106 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.82814512 |
| 107 | positive regulation of humoral immune response (GO:0002922) | 2.82490035 |
| 108 | negative regulation of production of molecular mediator of immune response (GO:0002701) | 2.81873483 |
| 109 | T-helper 1 type immune response (GO:0042088) | 2.81203007 |
| 110 | T cell costimulation (GO:0031295) | 2.81133719 |
| 111 | detection of bacterium (GO:0016045) | 2.80733454 |
| 112 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 2.80114971 |
| 113 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.79861198 |
| 114 | activation of MAPKKK activity (GO:0000185) | 2.79705781 |
| 115 | regulation of tolerance induction (GO:0002643) | 2.79701327 |
| 116 | negative regulation of cell killing (GO:0031342) | 2.78786774 |
| 117 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.78786774 |
| 118 | regulation of chronic inflammatory response (GO:0002676) | 2.77749909 |
| 119 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 2.77660842 |
| 120 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.77107356 |
| 121 | positive regulation of interleukin-17 production (GO:0032740) | 2.76214519 |
| 122 | T cell homeostasis (GO:0043029) | 2.75856360 |
| 123 | regulation of B cell mediated immunity (GO:0002712) | 2.75451064 |
| 124 | positive regulation of macrophage differentiation (GO:0045651) | 2.74268674 |
| 125 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 2.73426255 |
| 126 | positive regulation of cytokine biosynthetic process (GO:0042108) | 2.73074707 |
| 127 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.73032626 |
| 128 | regulation of regulatory T cell differentiation (GO:0045589) | 2.71249615 |
| 129 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.69808395 |
| 130 | positive thymic T cell selection (GO:0045059) | 2.69481681 |
| 131 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 2.68997959 |
| 132 | natural killer cell activation (GO:0030101) | 2.67984683 |
| 133 | positive regulation of defense response to virus by host (GO:0002230) | 2.67875189 |
| 134 | regulation of immunoglobulin mediated immune response (GO:0002889) | 2.67801192 |
| 135 | positive regulation of chemokine biosynthetic process (GO:0045080) | 2.66504819 |
| 136 | neutrophil activation (GO:0042119) | 2.66334845 |
| 137 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.65160523 |
| 138 | myeloid cell activation involved in immune response (GO:0002275) | 2.63949489 |
| 139 | response to muramyl dipeptide (GO:0032495) | 2.63434938 |
| 140 | leukocyte cell-cell adhesion (GO:0007159) | 2.63366927 |
| 141 | positive regulation of interferon-gamma production (GO:0032729) | 2.62033648 |
| 142 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.61933538 |
| 143 | positive regulation of DNA recombination (GO:0045911) | 2.61566076 |
| 144 | regulation of RIG-I signaling pathway (GO:0039535) | 2.60551070 |
| 145 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.60450754 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.10048149 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.41402340 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 4.23062640 |
| 4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.14581740 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.92842507 |
| 6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.89968989 |
| 7 | * STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.78786399 |
| 8 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.36044441 |
| 9 | * IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.23462204 |
| 10 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.08941953 |
| 11 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.03488559 |
| 12 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.94200189 |
| 13 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.72422537 |
| 14 | * STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.59245538 |
| 15 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.57376763 |
| 16 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.56947986 |
| 17 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.44518517 |
| 18 | MYC_22102868_ChIP-Seq_BL_Human | 2.43205631 |
| 19 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.41946896 |
| 20 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.36572701 |
| 21 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.36420150 |
| 22 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.33566005 |
| 23 | * MYB_26560356_Chip-Seq_TH2_Human | 2.31928832 |
| 24 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.29687022 |
| 25 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.28811008 |
| 26 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.22701749 |
| 27 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.22278884 |
| 28 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.11688263 |
| 29 | MAF_26560356_Chip-Seq_TH1_Human | 2.09568273 |
| 30 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.09467568 |
| 31 | MYB_26560356_Chip-Seq_TH1_Human | 2.03398586 |
| 32 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.03113946 |
| 33 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.02975684 |
| 34 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.96067938 |
| 35 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.93902107 |
| 36 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.85113033 |
| 37 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.79902417 |
| 38 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.76042682 |
| 39 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.73871688 |
| 40 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.73458971 |
| 41 | UTX_26944678_Chip-Seq_JUKART_Human | 1.73014959 |
| 42 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.71429640 |
| 43 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.69174262 |
| 44 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.69136313 |
| 45 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.63504882 |
| 46 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.60618406 |
| 47 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.59928927 |
| 48 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.56318675 |
| 49 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.48842317 |
| 50 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.48186828 |
| 51 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.46365950 |
| 52 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.43688461 |
| 53 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.42343616 |
| 54 | MAF_26560356_Chip-Seq_TH2_Human | 1.40777467 |
| 55 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.40634450 |
| 56 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.40479445 |
| 57 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.39271646 |
| 58 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.36754815 |
| 59 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.35904681 |
| 60 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.34958166 |
| 61 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.32564074 |
| 62 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.28949329 |
| 63 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.28317947 |
| 64 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.28052740 |
| 65 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.27681179 |
| 66 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.27290082 |
| 67 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.27047012 |
| 68 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.26135700 |
| 69 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.25768978 |
| 70 | SPI1_23127762_ChIP-Seq_K562_Human | 1.22532336 |
| 71 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.21696089 |
| 72 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.21433587 |
| 73 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.21326070 |
| 74 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.20877844 |
| 75 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.20334937 |
| 76 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.17159810 |
| 77 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.16160638 |
| 78 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.14816906 |
| 79 | GATA1_22025678_ChIP-Seq_K562_Human | 1.14550252 |
| 80 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.13159171 |
| 81 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.12935553 |
| 82 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.12133966 |
| 83 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.10238480 |
| 84 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.10010749 |
| 85 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.09754504 |
| 86 | GATA3_26560356_Chip-Seq_TH2_Human | 1.07288328 |
| 87 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.06953965 |
| 88 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.06857679 |
| 89 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.06078679 |
| 90 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.05047663 |
| 91 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.04903293 |
| 92 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.04536187 |
| 93 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.02301723 |
| 94 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.02293526 |
| 95 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.01966019 |
| 96 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.01091413 |
| 97 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.00987045 |
| 98 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.00758990 |
| 99 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00419778 |
| 100 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.99628050 |
| 101 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.99269844 |
| 102 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.98439249 |
| 103 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.97610764 |
| 104 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.96353645 |
| 105 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.96226250 |
| 106 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.94850151 |
| 107 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.94064277 |
| 108 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.93375360 |
| 109 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.92922380 |
| 110 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.92302544 |
| 111 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90666373 |
| 112 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.89169356 |
| 113 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.89085275 |
| 114 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.88267411 |
| 115 | * CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.88137011 |
| 116 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.87973614 |
| 117 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.87254997 |
| 118 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.86614321 |
| 119 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.84729893 |
| 120 | * RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.84326616 |
| 121 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.81241126 |
| 122 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80187355 |
| 123 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.79200536 |
| 124 | GATA1_19941826_ChIP-Seq_K562_Human | 0.77594357 |
| 125 | P300_27268052_Chip-Seq_Bcells_Human | 0.76438878 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 4.26076393 |
| 2 | MP0005671_abnormal_response_to | 4.02973464 |
| 3 | MP0009785_altered_susceptibility_to | 3.91185134 |
| 4 | MP0000685_abnormal_immune_system | 3.47615117 |
| 5 | MP0003436_decreased_susceptibility_to | 3.16882022 |
| 6 | MP0003724_increased_susceptibility_to | 3.16111443 |
| 7 | MP0003763_abnormal_thymus_physiology | 3.13129409 |
| 8 | * MP0005000_abnormal_immune_tolerance | 3.06756466 |
| 9 | MP0002148_abnormal_hypersensitivity_rea | 3.06523012 |
| 10 | MP0005025_abnormal_response_to | 3.02895671 |
| 11 | * MP0001800_abnormal_humoral_immune | 3.01612867 |
| 12 | MP0001790_abnormal_immune_system | 2.92559417 |
| 13 | MP0005387_immune_system_phenotype | 2.92559417 |
| 14 | * MP0002723_abnormal_immune_serum | 2.80852220 |
| 15 | * MP0002452_abnormal_antigen_presenting | 2.75913725 |
| 16 | * MP0002420_abnormal_adaptive_immunity | 2.66106679 |
| 17 | MP0001819_abnormal_immune_cell | 2.66077636 |
| 18 | MP0002419_abnormal_innate_immunity | 2.59779187 |
| 19 | MP0002396_abnormal_hematopoietic_system | 2.46110703 |
| 20 | * MP0002398_abnormal_bone_marrow | 2.42432395 |
| 21 | MP0009333_abnormal_splenocyte_physiolog | 2.39013021 |
| 22 | MP0006082_CNS_inflammation | 2.29948524 |
| 23 | MP0005464_abnormal_platelet_physiology | 2.24268170 |
| 24 | MP0000716_abnormal_immune_system | 2.22080877 |
| 25 | MP0010155_abnormal_intestine_physiology | 2.19851067 |
| 26 | MP0002405_respiratory_system_inflammati | 2.16710452 |
| 27 | MP0001853_heart_inflammation | 2.16427721 |
| 28 | MP0003303_peritoneal_inflammation | 2.04894634 |
| 29 | MP0002166_altered_tumor_susceptibility | 2.02146980 |
| 30 | MP0000689_abnormal_spleen_morphology | 2.00399320 |
| 31 | MP0002006_tumorigenesis | 1.96473068 |
| 32 | MP0002722_abnormal_immune_system | 1.95569544 |
| 33 | MP0005397_hematopoietic_system_phenotyp | 1.94433051 |
| 34 | MP0001545_abnormal_hematopoietic_system | 1.94433051 |
| 35 | MP0001873_stomach_inflammation | 1.94291131 |
| 36 | MP0001845_abnormal_inflammatory_respons | 1.91151362 |
| 37 | MP0002429_abnormal_blood_cell | 1.88798611 |
| 38 | MP0004510_myositis | 1.87557707 |
| 39 | MP0004808_abnormal_hematopoietic_stem | 1.84753761 |
| 40 | MP0009840_abnormal_foam_cell | 1.79799628 |
| 41 | MP0004947_skin_inflammation | 1.78969998 |
| 42 | MP0002138_abnormal_hepatobiliary_system | 1.77827589 |
| 43 | MP0003806_abnormal_nucleotide_metabolis | 1.76471038 |
| 44 | MP0003866_abnormal_defecation | 1.70662782 |
| 45 | MP0002139_abnormal_hepatobiliary_system | 1.68264359 |
| 46 | MP0000703_abnormal_thymus_morphology | 1.63267750 |
| 47 | MP0005174_abnormal_tail_pigmentation | 1.58048209 |
| 48 | MP0002254_reproductive_system_inflammat | 1.55479281 |
| 49 | MP0008469_abnormal_protein_level | 1.54957581 |
| 50 | MP0000490_abnormal_crypts_of | 1.53747641 |
| 51 | MP0001533_abnormal_skeleton_physiology | 1.51479151 |
| 52 | MP0005451_abnormal_body_composition | 1.42759908 |
| 53 | MP0000465_gastrointestinal_hemorrhage | 1.41793548 |
| 54 | MP0003448_altered_tumor_morphology | 1.38939751 |
| 55 | MP0002933_joint_inflammation | 1.36779016 |
| 56 | MP0000858_altered_metastatic_potential | 1.36516580 |
| 57 | MP0000604_amyloidosis | 1.31200354 |
| 58 | MP0009278_abnormal_bone_marrow | 1.30022416 |
| 59 | MP0009764_decreased_sensitivity_to | 1.26999218 |
| 60 | MP0005075_abnormal_melanosome_morpholog | 1.26632985 |
| 61 | MP0005310_abnormal_salivary_gland | 1.25890788 |
| 62 | MP0003300_gastrointestinal_ulcer | 1.24881415 |
| 63 | MP0008057_abnormal_DNA_replication | 1.22575430 |
| 64 | MP0006054_spinal_hemorrhage | 1.19101638 |
| 65 | MP0000343_altered_response_to | 1.18441909 |
| 66 | MP0003453_abnormal_keratinocyte_physiol | 1.16466570 |
| 67 | MP0002019_abnormal_tumor_incidence | 1.08892671 |
| 68 | MP0008007_abnormal_cellular_replicative | 1.02639601 |
| 69 | MP0003693_abnormal_embryo_hatching | 1.02034106 |
| 70 | MP0005167_abnormal_blood-brain_barrier | 0.97438854 |
| 71 | MP0002095_abnormal_skin_pigmentation | 0.92278527 |
| 72 | MP0009763_increased_sensitivity_to | 0.92089275 |
| 73 | MP0010094_abnormal_chromosome_stability | 0.89848346 |
| 74 | MP0008058_abnormal_DNA_repair | 0.89798988 |
| 75 | MP0002998_abnormal_bone_remodeling | 0.88331234 |
| 76 | MP0008004_abnormal_stomach_pH | 0.84681016 |
| 77 | MP0000015_abnormal_ear_pigmentation | 0.83964649 |
| 78 | MP0003077_abnormal_cell_cycle | 0.83630538 |
| 79 | MP0002332_abnormal_exercise_endurance | 0.83525672 |
| 80 | MP0010352_gastrointestinal_tract_polyps | 0.83199012 |
| 81 | MP0005166_decreased_susceptibility_to | 0.81415125 |
| 82 | MP0003075_altered_response_to | 0.80611338 |
| 83 | MP0003828_pulmonary_edema | 0.78295310 |
| 84 | MP0003186_abnormal_redox_activity | 0.77568790 |
| 85 | MP0002693_abnormal_pancreas_physiology | 0.77099146 |
| 86 | MP0010307_abnormal_tumor_latency | 0.75840079 |
| 87 | MP0005165_increased_susceptibility_to | 0.72838500 |
| 88 | MP0001851_eye_inflammation | 0.71909452 |
| 89 | MP0001663_abnormal_digestive_system | 0.71782790 |
| 90 | MP0003172_abnormal_lysosome_physiology | 0.71745865 |
| 91 | MP0002132_abnormal_respiratory_system | 0.71018226 |
| 92 | MP0005058_abnormal_lysosome_morphology | 0.70702076 |
| 93 | MP0009765_abnormal_xenobiotic_induced | 0.66738617 |
| 94 | MP0003690_abnormal_glial_cell | 0.66666203 |
| 95 | MP0000313_abnormal_cell_death | 0.66486868 |
| 96 | MP0001501_abnormal_sleep_pattern | 0.63513904 |
| 97 | MP0000249_abnormal_blood_vessel | 0.63418376 |
| 98 | MP0008873_increased_physiological_sensi | 0.62350037 |
| 99 | MP0005390_skeleton_phenotype | 0.62332760 |
| 100 | MP0008874_decreased_physiological_sensi | 0.61896168 |
| 101 | MP0002277_abnormal_respiratory_mucosa | 0.60747847 |
| 102 | MP0003191_abnormal_cellular_cholesterol | 0.58230112 |
| 103 | MP0003183_abnormal_peptide_metabolism | 0.58136253 |
| 104 | MP0004782_abnormal_surfactant_physiolog | 0.57742833 |
| 105 | MP0000609_abnormal_liver_physiology | 0.57304334 |
| 106 | MP0003195_calcinosis | 0.56852647 |
| 107 | MP0003795_abnormal_bone_structure | 0.56014757 |
| 108 | MP0001919_abnormal_reproductive_system | 0.55950985 |
| 109 | MP0001542_abnormal_bone_strength | 0.55731820 |
| 110 | MP0008260_abnormal_autophagy | 0.55342596 |
| 111 | MP0005023_abnormal_wound_healing | 0.54831455 |
| 112 | MP0001986_abnormal_taste_sensitivity | 0.53891505 |
| 113 | MP0005381_digestive/alimentary_phenotyp | 0.53676417 |
| 114 | MP0003045_fibrosis | 0.53354688 |
| 115 | MP0005319_abnormal_enzyme/_coenzyme | 0.53040930 |
| 116 | MP0000371_diluted_coat_color | 0.52941434 |
| 117 | MP0003091_abnormal_cell_migration | 0.52940517 |
| 118 | MP0004147_increased_porphyrin_level | 0.52848140 |
| 119 | MP0001191_abnormal_skin_condition | 0.50610259 |
| 120 | MP0004957_abnormal_blastocyst_morpholog | 0.50200056 |
| 121 | MP0003656_abnormal_erythrocyte_physiolo | 0.50165278 |
| 122 | MP0003943_abnormal_hepatobiliary_system | 0.49845677 |
| 123 | MP0002877_abnormal_melanocyte_morpholog | 0.48441399 |
| 124 | MP0004381_abnormal_hair_follicle | 0.48171024 |
| 125 | MP0000477_abnormal_intestine_morphology | 0.48094464 |
| 126 | MP0002136_abnormal_kidney_physiology | 0.45493347 |
| 127 | MP0003111_abnormal_nucleus_morphology | 0.45038927 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.69264080 |
| 2 | Recurrent abscess formation (HP:0002722) | 5.16393147 |
| 3 | Myositis (HP:0100614) | 5.06497422 |
| 4 | Eczematoid dermatitis (HP:0000976) | 4.89486294 |
| 5 | Abnormality of glycolipid metabolism (HP:0010969) | 4.77883171 |
| 6 | Abnormality of liposaccharide metabolism (HP:0010968) | 4.77883171 |
| 7 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 4.77883171 |
| 8 | Recurrent bacterial skin infections (HP:0005406) | 4.68586255 |
| 9 | IgM deficiency (HP:0002850) | 4.62633921 |
| 10 | Stomatitis (HP:0010280) | 4.28494816 |
| 11 | Chronic otitis media (HP:0000389) | 4.21394802 |
| 12 | Thrombocytosis (HP:0001894) | 4.18345176 |
| 13 | Mediastinal lymphadenopathy (HP:0100721) | 4.12615123 |
| 14 | Orchitis (HP:0100796) | 3.97729350 |
| 15 | Retrobulbar optic neuritis (HP:0100654) | 3.96680943 |
| 16 | Optic neuritis (HP:0100653) | 3.96680943 |
| 17 | Recurrent bronchitis (HP:0002837) | 3.93969872 |
| 18 | Recurrent fungal infections (HP:0002841) | 3.75404433 |
| 19 | Vasculitis (HP:0002633) | 3.69824269 |
| 20 | Recurrent viral infections (HP:0004429) | 3.69273773 |
| 21 | Petechiae (HP:0000967) | 3.65988136 |
| 22 | Abnormality of T cells (HP:0002843) | 3.61323621 |
| 23 | Abnormality of T cell number (HP:0011839) | 3.53526863 |
| 24 | Abnormality of T cell physiology (HP:0011840) | 3.49381858 |
| 25 | T lymphocytopenia (HP:0005403) | 3.48850538 |
| 26 | Increased cerebral lipofuscin (HP:0011813) | 3.47594342 |
| 27 | Disinhibition (HP:0000734) | 3.41870194 |
| 28 | Meningitis (HP:0001287) | 3.41330776 |
| 29 | Systemic lupus erythematosus (HP:0002725) | 3.41005198 |
| 30 | Abnormality of macrophages (HP:0004311) | 3.40306963 |
| 31 | Obstructive lung disease (HP:0006536) | 3.37319213 |
| 32 | Chronic obstructive pulmonary disease (HP:0006510) | 3.37319213 |
| 33 | Increased IgM level (HP:0003496) | 3.32975352 |
| 34 | IgG deficiency (HP:0004315) | 3.30206929 |
| 35 | Recurrent skin infections (HP:0001581) | 3.29566612 |
| 36 | Loss of speech (HP:0002371) | 3.22573741 |
| 37 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.13277939 |
| 38 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.13192912 |
| 39 | Autoimmune thrombocytopenia (HP:0001973) | 3.10295854 |
| 40 | Dysostosis multiplex (HP:0000943) | 3.09294824 |
| 41 | Pulmonary infiltrates (HP:0002113) | 3.04647912 |
| 42 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.03386129 |
| 43 | Nasal polyposis (HP:0100582) | 3.02158201 |
| 44 | Hemoptysis (HP:0002105) | 2.97546687 |
| 45 | Cellulitis (HP:0100658) | 2.96989805 |
| 46 | Interstitial pulmonary disease (HP:0006530) | 2.94723584 |
| 47 | B lymphocytopenia (HP:0010976) | 2.92587557 |
| 48 | Abnormality of B cell number (HP:0010975) | 2.92587557 |
| 49 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.92396057 |
| 50 | Lymphopenia (HP:0001888) | 2.90715824 |
| 51 | Abnormality of the prostate (HP:0008775) | 2.88966229 |
| 52 | Abnormality of the nasal mucosa (HP:0000433) | 2.88468978 |
| 53 | IgA deficiency (HP:0002720) | 2.88322451 |
| 54 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.87881096 |
| 55 | Chronic mucocutaneous candidiasis (HP:0002728) | 2.87685226 |
| 56 | Recurrent cutaneous fungal infections (HP:0011370) | 2.87685226 |
| 57 | Gastrointestinal infarctions (HP:0005244) | 2.87560354 |
| 58 | Hypergammaglobulinemia (HP:0010702) | 2.86164997 |
| 59 | Panhypogammaglobulinemia (HP:0003139) | 2.85712286 |
| 60 | Epistaxis (HP:0000421) | 2.82192215 |
| 61 | Aplastic anemia (HP:0001915) | 2.77911665 |
| 62 | Gastrointestinal stroma tumor (HP:0100723) | 2.77367815 |
| 63 | Arterial thrombosis (HP:0004420) | 2.76722682 |
| 64 | Spontaneous hematomas (HP:0007420) | 2.74984196 |
| 65 | Pustule (HP:0200039) | 2.73159481 |
| 66 | Keratoconjunctivitis sicca (HP:0001097) | 2.72023512 |
| 67 | Prolonged bleeding time (HP:0003010) | 2.71228488 |
| 68 | Abnormal number of erythroid precursors (HP:0012131) | 2.68825461 |
| 69 | Chest pain (HP:0100749) | 2.68199228 |
| 70 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.67715683 |
| 71 | Encephalitis (HP:0002383) | 2.66289266 |
| 72 | Increased serum ferritin (HP:0003281) | 2.64873544 |
| 73 | Leukocytosis (HP:0001974) | 2.62252604 |
| 74 | Reticulocytopenia (HP:0001896) | 2.62171858 |
| 75 | Autoimmune hemolytic anemia (HP:0001890) | 2.61718626 |
| 76 | Chronic diarrhea (HP:0002028) | 2.58834882 |
| 77 | Gastrointestinal inflammation (HP:0004386) | 2.58447991 |
| 78 | Lymphoma (HP:0002665) | 2.58405676 |
| 79 | Gingivitis (HP:0000230) | 2.56199451 |
| 80 | Inflammation of the large intestine (HP:0002037) | 2.52734283 |
| 81 | Agammaglobulinemia (HP:0004432) | 2.51515020 |
| 82 | Mutism (HP:0002300) | 2.50914506 |
| 83 | Amaurosis fugax (HP:0100576) | 2.49751460 |
| 84 | Gingival bleeding (HP:0000225) | 2.48037275 |
| 85 | Keratoconjunctivitis (HP:0001096) | 2.46518998 |
| 86 | Abnormality of eosinophils (HP:0001879) | 2.44538892 |
| 87 | Purpura (HP:0000979) | 2.39477074 |
| 88 | Joint swelling (HP:0001386) | 2.38628276 |
| 89 | Severe combined immunodeficiency (HP:0004430) | 2.37992404 |
| 90 | Recurrent sinusitis (HP:0011108) | 2.37574737 |
| 91 | Polyneuropathy (HP:0001271) | 2.34197472 |
| 92 | Agnosia (HP:0010524) | 2.33460332 |
| 93 | Thyroiditis (HP:0100646) | 2.32778944 |
| 94 | Combined immunodeficiency (HP:0005387) | 2.31400297 |
| 95 | Neutropenia (HP:0001875) | 2.27204421 |
| 96 | Periodontitis (HP:0000704) | 2.26969331 |
| 97 | Restrictive lung disease (HP:0002091) | 2.26571821 |
| 98 | Hepatosplenomegaly (HP:0001433) | 2.21641500 |
| 99 | Increased IgE level (HP:0003212) | 2.21343841 |
| 100 | Granulocytopenia (HP:0001913) | 2.21343211 |
| 101 | Abnormal platelet function (HP:0011869) | 2.21008687 |
| 102 | Impaired platelet aggregation (HP:0003540) | 2.21008687 |
| 103 | Gangrene (HP:0100758) | 2.19876606 |
| 104 | Eosinophilia (HP:0001880) | 2.18717853 |
| 105 | Axonal loss (HP:0003447) | 2.18332444 |
| 106 | Urticaria (HP:0001025) | 2.17364286 |
| 107 | Personality changes (HP:0000751) | 2.16723804 |
| 108 | Pulmonary embolism (HP:0002204) | 2.16090680 |
| 109 | Vacuolated lymphocytes (HP:0001922) | 2.14787997 |
| 110 | Abnormality of the pleura (HP:0002103) | 2.13960711 |
| 111 | Bronchitis (HP:0012387) | 2.12998477 |
| 112 | Recurrent pneumonia (HP:0006532) | 2.12980899 |
| 113 | Basal ganglia calcification (HP:0002135) | 2.12694661 |
| 114 | Abnormality of iron homeostasis (HP:0011031) | 2.10587624 |
| 115 | Anorexia (HP:0002039) | 2.09104800 |
| 116 | Chronic sinusitis (HP:0011109) | 2.09032517 |
| 117 | Neurofibrillary tangles (HP:0002185) | 2.07194212 |
| 118 | Acute myeloid leukemia (HP:0004808) | 2.06407791 |
| 119 | Parakeratosis (HP:0001036) | 2.06300163 |
| 120 | Recurrent lower respiratory tract infections (HP:0002783) | 2.05533296 |
| 121 | Glomerulonephritis (HP:0000099) | 2.05117691 |
| 122 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.03359366 |
| 123 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.03359366 |
| 124 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.03359366 |
| 125 | Pallor (HP:0000980) | 2.01711345 |
| 126 | Glomerulopathy (HP:0100820) | 2.01621304 |
| 127 | Arthralgia (HP:0002829) | 1.99799127 |
| 128 | Emphysema (HP:0002097) | 1.97772204 |
| 129 | Progressive neurologic deterioration (HP:0002344) | 1.97311727 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 4.50174991 |
| 2 | TXK | 4.38495093 |
| 3 | JAK3 | 2.90457767 |
| 4 | MAP3K14 | 2.85819457 |
| 5 | TBK1 | 2.83479148 |
| 6 | KIT | 2.62668501 |
| 7 | TYK2 | 2.54074570 |
| 8 | BLK | 2.49188338 |
| 9 | TAOK2 | 2.46421643 |
| 10 | ZAP70 | 2.46217858 |
| 11 | NME2 | 2.46058784 |
| 12 | IKBKE | 2.44898312 |
| 13 | GRK7 | 2.44296999 |
| 14 | IRAK4 | 2.37564749 |
| 15 | TEC | 2.34656430 |
| 16 | BTK | 2.31953121 |
| 17 | IKBKB | 2.04618337 |
| 18 | PRPF4B | 1.90364925 |
| 19 | SYK | 1.87106580 |
| 20 | PIM2 | 1.84011697 |
| 21 | ITK | 1.79939327 |
| 22 | IRAK3 | 1.73164426 |
| 23 | MAP3K12 | 1.70130789 |
| 24 | RIPK4 | 1.61079824 |
| 25 | TAOK1 | 1.58461139 |
| 26 | LCK | 1.50389656 |
| 27 | JAK1 | 1.49208506 |
| 28 | CSF1R | 1.44691989 |
| 29 | STK10 | 1.40020237 |
| 30 | NLK | 1.34154107 |
| 31 | RPS6KA4 | 1.31565467 |
| 32 | TGFBR2 | 1.30127653 |
| 33 | HCK | 1.29580050 |
| 34 | LYN | 1.28000437 |
| 35 | MAP3K3 | 1.27620148 |
| 36 | TGFBR1 | 1.25863838 |
| 37 | BCKDK | 1.21362757 |
| 38 | MOS | 1.19755145 |
| 39 | FLT3 | 1.19299173 |
| 40 | PIM1 | 1.18500346 |
| 41 | FGR | 1.15588277 |
| 42 | EEF2K | 1.15046442 |
| 43 | DDR2 | 1.11870144 |
| 44 | KDR | 1.11647698 |
| 45 | ERN1 | 1.11141720 |
| 46 | CHUK | 1.08846577 |
| 47 | MAP2K3 | 1.07813173 |
| 48 | CLK1 | 1.07150772 |
| 49 | BMPR2 | 1.05458749 |
| 50 | FGFR4 | 1.04857205 |
| 51 | LRRK2 | 1.04506484 |
| 52 | CSK | 1.04300734 |
| 53 | ACVR1B | 1.03057984 |
| 54 | GRK6 | 1.02296639 |
| 55 | FES | 1.00646214 |
| 56 | STK16 | 0.97563175 |
| 57 | MAP3K1 | 0.94753931 |
| 58 | MATK | 0.93220396 |
| 59 | EPHB1 | 0.91773259 |
| 60 | MAP3K13 | 0.90549918 |
| 61 | TAOK3 | 0.82190131 |
| 62 | JAK2 | 0.79698867 |
| 63 | MST4 | 0.78095793 |
| 64 | SIK3 | 0.76561458 |
| 65 | NEK9 | 0.73987094 |
| 66 | ARAF | 0.73829746 |
| 67 | EIF2AK1 | 0.72529813 |
| 68 | FGFR3 | 0.71123018 |
| 69 | WEE1 | 0.70129985 |
| 70 | TNK2 | 0.69304997 |
| 71 | MAPK11 | 0.69024696 |
| 72 | EPHA3 | 0.68568087 |
| 73 | MAP3K5 | 0.67980666 |
| 74 | EIF2AK3 | 0.67147796 |
| 75 | MARK3 | 0.64320400 |
| 76 | CDC42BPA | 0.63842285 |
| 77 | TLK1 | 0.63176529 |
| 78 | TYRO3 | 0.61851009 |
| 79 | TSSK6 | 0.61406700 |
| 80 | ADRBK2 | 0.59557163 |
| 81 | ABL2 | 0.58817454 |
| 82 | TNIK | 0.58095138 |
| 83 | MAP3K11 | 0.57446053 |
| 84 | PRKG2 | 0.55632824 |
| 85 | EIF2AK2 | 0.55025227 |
| 86 | TESK2 | 0.54521456 |
| 87 | RPS6KB2 | 0.53874652 |
| 88 | CDK19 | 0.53523954 |
| 89 | VRK1 | 0.52251194 |
| 90 | ATR | 0.51685145 |
| 91 | CDK4 | 0.50666062 |
| 92 | SMG1 | 0.50501019 |
| 93 | MUSK | 0.48157456 |
| 94 | PRKCQ | 0.48129993 |
| 95 | MAPK4 | 0.48056473 |
| 96 | NEK2 | 0.46890138 |
| 97 | IRAK1 | 0.46394935 |
| 98 | RPS6KA6 | 0.46274790 |
| 99 | SCYL2 | 0.45059174 |
| 100 | IRAK2 | 0.44524054 |
| 101 | RIPK1 | 0.44218260 |
| 102 | MAPKAPK3 | 0.42608010 |
| 103 | SIK2 | 0.42602453 |
| 104 | MAP3K10 | 0.42420194 |
| 105 | PDK1 | 0.41150905 |
| 106 | CAMKK2 | 0.40907981 |
| 107 | PRKCD | 0.39112048 |
| 108 | ALK | 0.38684322 |
| 109 | RAF1 | 0.38174106 |
| 110 | TESK1 | 0.38082460 |
| 111 | HIPK2 | 0.37141137 |
| 112 | MAPKAPK2 | 0.36908115 |
| 113 | RPS6KA5 | 0.35580893 |
| 114 | PAK4 | 0.35482539 |
| 115 | PKN2 | 0.35356533 |
| 116 | STK4 | 0.35205360 |
| 117 | BUB1 | 0.35197328 |
| 118 | CDK7 | 0.34861660 |
| 119 | MAP2K6 | 0.33934348 |
| 120 | DAPK1 | 0.33314570 |
| 121 | MYLK | 0.33007645 |
| 122 | ABL1 | 0.32415929 |
| 123 | INSR | 0.30416098 |
| 124 | RPS6KC1 | 0.30263343 |
| 125 | RPS6KL1 | 0.30263343 |
| 126 | MKNK1 | 0.30170200 |
| 127 | FYN | 0.29593249 |
| 128 | MAPK3 | 0.28709397 |
| 129 | SIK1 | 0.28041319 |
| 130 | DAPK3 | 0.22357820 |
| 131 | MAP3K8 | 0.21310891 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Allograft rejection_Homo sapiens_hsa05330 | 3.52891834 |
| 2 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.15475960 |
| 3 | Graft-versus-host disease_Homo sapiens_hsa05332 | 2.95999675 |
| 4 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.79855402 |
| 5 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.73141498 |
| 6 | Leishmaniasis_Homo sapiens_hsa05140 | 2.66852801 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.56653124 |
| 8 | Asthma_Homo sapiens_hsa05310 | 2.52823405 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.49477361 |
| 10 | Measles_Homo sapiens_hsa05162 | 2.39596592 |
| 11 | Ribosome_Homo sapiens_hsa03010 | 2.33247691 |
| 12 | DNA replication_Homo sapiens_hsa03030 | 2.15206259 |
| 13 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.11117750 |
| 14 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.04413088 |
| 15 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.97420126 |
| 16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.94433855 |
| 17 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.92342340 |
| 18 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.91268986 |
| 19 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.85522760 |
| 20 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.84323815 |
| 21 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.81351835 |
| 22 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.77764913 |
| 23 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.75832709 |
| 24 | Legionellosis_Homo sapiens_hsa05134 | 1.74276835 |
| 25 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.71673719 |
| 26 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.71145067 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.54852389 |
| 28 | Malaria_Homo sapiens_hsa05144 | 1.53568265 |
| 29 | Mismatch repair_Homo sapiens_hsa03430 | 1.51578701 |
| 30 | Pertussis_Homo sapiens_hsa05133 | 1.50013662 |
| 31 | Influenza A_Homo sapiens_hsa05164 | 1.48092909 |
| 32 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.41249761 |
| 33 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.39443888 |
| 34 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.39192742 |
| 35 | Proteasome_Homo sapiens_hsa03050 | 1.37640421 |
| 36 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.26647512 |
| 37 | Tuberculosis_Homo sapiens_hsa05152 | 1.21521136 |
| 38 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.19508228 |
| 39 | Apoptosis_Homo sapiens_hsa04210 | 1.18511639 |
| 40 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.14858869 |
| 41 | Shigellosis_Homo sapiens_hsa05131 | 1.13968622 |
| 42 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.11659479 |
| 43 | Viral myocarditis_Homo sapiens_hsa05416 | 1.11345872 |
| 44 | Hepatitis B_Homo sapiens_hsa05161 | 1.11143557 |
| 45 | Homologous recombination_Homo sapiens_hsa03440 | 1.06708492 |
| 46 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.06543686 |
| 47 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.06275395 |
| 48 | Salmonella infection_Homo sapiens_hsa05132 | 1.05214942 |
| 49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98533486 |
| 50 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.98442814 |
| 51 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.97495571 |
| 52 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.96873389 |
| 53 | RNA polymerase_Homo sapiens_hsa03020 | 0.92571728 |
| 54 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.91302706 |
| 55 | Spliceosome_Homo sapiens_hsa03040 | 0.88880564 |
| 56 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.87531579 |
| 57 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.87112276 |
| 58 | Prion diseases_Homo sapiens_hsa05020 | 0.82660715 |
| 59 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.82435274 |
| 60 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.79818130 |
| 61 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.79064997 |
| 62 | Platelet activation_Homo sapiens_hsa04611 | 0.77371472 |
| 63 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.76284503 |
| 64 | Hepatitis C_Homo sapiens_hsa05160 | 0.73098463 |
| 65 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.72756716 |
| 66 | Other glycan degradation_Homo sapiens_hsa00511 | 0.72285207 |
| 67 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.69823695 |
| 68 | RNA degradation_Homo sapiens_hsa03018 | 0.68980636 |
| 69 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.68288174 |
| 70 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.67979472 |
| 71 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.67056230 |
| 72 | HTLV-I infection_Homo sapiens_hsa05166 | 0.63816613 |
| 73 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.63247754 |
| 74 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.61449151 |
| 75 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.60180329 |
| 76 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.58058127 |
| 77 | Protein export_Homo sapiens_hsa03060 | 0.57275638 |
| 78 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.55644803 |
| 79 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.54583308 |
| 80 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.54579030 |
| 81 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.51142779 |
| 82 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.50613145 |
| 83 | Bladder cancer_Homo sapiens_hsa05219 | 0.46171575 |
| 84 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.44600817 |
| 85 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.44374413 |
| 86 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.39976613 |
| 87 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.39526161 |
| 88 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.39247110 |
| 89 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.37115956 |
| 90 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.36277707 |
| 91 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.36261818 |
| 92 | Phagosome_Homo sapiens_hsa04145 | 0.35761091 |
| 93 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.35595225 |
| 94 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.34553565 |
| 95 | Lysosome_Homo sapiens_hsa04142 | 0.33697047 |
| 96 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.32796666 |
| 97 | Cell cycle_Homo sapiens_hsa04110 | 0.32477302 |
| 98 | Purine metabolism_Homo sapiens_hsa00230 | 0.32440422 |
| 99 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.31733996 |
| 100 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.31006623 |
| 101 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.30854079 |
| 102 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.30249471 |
| 103 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.30035784 |
| 104 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.28923699 |
| 105 | RNA transport_Homo sapiens_hsa03013 | 0.28170500 |
| 106 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.27164873 |
| 107 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.26820851 |
| 108 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.25629754 |
| 109 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.24569928 |
| 110 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.23865172 |
| 111 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.23808084 |
| 112 | Amoebiasis_Homo sapiens_hsa05146 | 0.21984860 |
| 113 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.21799215 |
| 114 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.20616989 |
| 115 | Endocytosis_Homo sapiens_hsa04144 | 0.20324708 |
| 116 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.15033141 |
| 117 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.13987154 |
| 118 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.13800405 |
| 119 | Insulin resistance_Homo sapiens_hsa04931 | 0.12163140 |
| 120 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.10689227 |
| 121 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.03663178 |
| 122 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.01921059 |
| 123 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.00241663 |
| 124 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | -0.0226991 |
| 125 | Galactose metabolism_Homo sapiens_hsa00052 | -0.0178259 |
| 126 | Mineral absorption_Homo sapiens_hsa04978 | -0.0128920 |
| 127 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | -0.0105325 |

